MEP1B Gene
protein-coding GIFtS: 61
GCID: GC18P029793
|
|
meprin A, beta
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Aliases
for MEP1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Meprin A, Beta1 2 | | Endopeptidase-23 | | Meprin B2 3 | | Meprin A Subunit Beta2 | | N-Benzoyl-L-Tyrosyl-P-Amino-Benzoic Acid Hydrolase Subunit Beta2 3 | | N-Benzoyl-L-Tyrosyl-P-Amino-Benzoic Acid Hydrolase Beta Subunit2 | | PABA Peptide Hydrolase2 3 | | EC 3.4.24.633 | | PPH Beta2 3 | | Endopeptidase-23 |
Export aliases for MEP1B gene to outside databasesPrevious GC identifers: GC18P029589 GC18P028021 GC18P028023 GC18P026626 |
Summaries
for MEP1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MEP1B:
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush bordermembranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide andprotein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers ofevolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit aresecreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the betasubunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, anddistribution of the membrane-associated alpha subunit in kidney and intestine. (provided by RefSeq, Oct 2011)
UniProtKB/Swiss-Prot: MEP1B_HUMAN, Q16820Function: Membrane metallopeptidase that sheds many membrane-bound proteins. Known substrates include: FGF19, VGFA,IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of severalpro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodelingdue to its capability to degrade extracellular matrix components
Gene Wiki entry for MEP1B
|
Genomic Views
for MEP1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010966.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MEP1B gene promoter:
Nkx2-2 SREBP-1c MyoD MIF-1 Cdc5 SREBP-1b SREBP-1a SEF-1 (1) En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MEP1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEP1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q12.2-q12.3 Ensembl cytogenetic band: 18q12.1 HGNC cytogenetic band: 18q12.2-q12.3MEP1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P029793: view genomic region
(about GC identifiers)
Start:
|
29,765,032 bp from pter |
End:
|
29,800,367 bp from pter |
Size:
|
35,336 bases |
Orientation:
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plus strand |
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Proteins
for MEP1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MEP1B_HUMAN, Q16820 (See
protein sequence)Recommended Name: Meprin A subunit beta precursor Size: 701 amino acids; 79571 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Homotetramer consisting of disulfide-linked beta subunits, or heterotetramer of two alpha and two betasubunits formed by non-covalent association of two disulfide-linked heterodimers (By similarity). Interacts with MBL2through its carbohydrate moiety. This interaction may inhibit its catalytic activity (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein. Secreted. Note=Homodimers are essentiallymembrane bound but may also be shed from the surface by ADAM-10 and ADAM-17
2 PDB 3D structures from  and Proteopedia  for MEP1B:4GWM (3D)
4GWN (3D)
Secondary accessions: B7ZM35 B9EGL6 Q670J1Explore the universe of human proteins at neXtProt for MEP1B: NX_Q16820
Post-translational modifications:
N-glycosylated; contains high mannose and/or complex biantennary structures1
O-glycosylation protect the C-terminal region from proteolytic cleavage and diminish secretion, this seems to bespecific to human1
Proteolytically activated by trypsin in the intestinal lumen and kallikrein-related peptidases in other tissues1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q16820
MEP1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005916.2
ENSEMBL proteins: ENSP00000462038 ENSP00000269202 ENSP00000463280
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
MEP1B for ontologies About GeneDecksing
MEP1B Antibody Products:
Assay Products for MEP1B: |
Protein
Domains /
Families
for MEP1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MEP1B for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry Q16820ProtoNet protein and cluster: Q16820 4 Blocks protein families: IPB000998 MAM domain signature IPB001506 Astacin family signature IPB002083 Meprin/TRAF-like MATH IPB006210 Type I EGF
UniProtKB/Swiss-Prot: MEP1B_HUMAN, Q16820Similarity: Belongs to the peptidase M12A familySimilarity: Contains 1 EGF-like domainSimilarity: Contains 1 MAM domainSimilarity: Contains 1 MATH domain |
Function
for MEP1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MEP1B_HUMAN, Q16820Function: Membrane metallopeptidase that sheds many membrane-bound proteins. Known substrates include: FGF19, VGFA,IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of severalpro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodelingdue to its capability to degrade extracellular matrix componentsCatalytic activity: Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of 5-His- -Leu-6, 6-Leu--Cys-7, 14-Ala- -Leu-15 and 19-Cys- -Gly-20 bonds in insulin B chain. Exhibits a strong preference for acidicamino-acids at the P1' positionEnzyme regulation: Strongly inhibited by fetuin-A/AHSG Genatlas biochemistry entry for MEP1B:zinc metalloendopeptidase 1,meprin,beta subunit,astacin family
Enzyme Number (IUBMB): EC 3.4.24.631
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEP1B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEP1B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MEP1B (NM_005925) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MEP1B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEP1B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEP1B |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004222 | metalloendopeptidase activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
MEP1B for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Mep1btm1Bond for MEP1B
6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Mep1b):
MEP1B for phenotypes About GeneDecksing
|
Pathways & Interactions
for MEP1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | G Protein Signaling Pathways | | | 2 | Protein digestion and absorption | | | 3 | Activation of cAMP-Dependent PKA | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for MEP1B
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MEP1B
1  GeneGo (Thomson Reuters) Pathway for MEP1B
1 
Kegg Pathway (Kegg details for MEP1B):
MEP1B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MEP1B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 17)
5/19 Interacting proteins for MEP1B (Q168202, 3 ENSP000002692024) via UniProtKB, MINT, STRING, and/or I2D (see all 19)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
MEP1B for ontologies About GeneDecksing
|
Drugs & Compounds
for MEP1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MEP1B for compounds About GeneDecksing
 Browse Tocris compounds for MEP1B
1 Novoseek chemical compound relationship for MEP1B gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| polysaccharide |
17.9 |
1 |
12387727 (1) |
Search CenterWatch for drugs/clinical trials and news about MEP1B
|
Transcripts
for MEP1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MEP1B gene: NM_005925.2 Unigene Cluster for MEP1B: Meprin A, beta Hs.194777 [show with all ESTs]Unigene Representative Sequence: AY6959314 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000581184 ENST00000269202(uc002kxj.4) ENST00000581447 ENST00000579919
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEP1B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEP1B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MEP1B (NM_005925) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MEP1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEP1B |
Additional cDNA sequence: AY695931.1 BC136559.1 BC144244.1 X81333.1 4 DOTS entries: DT.40255945 DT.121103370 DT.121103371 DT.97769837 14 AceView cDNA sequences: AW951419 BX280186 NM_005925 AA298414 X81333 AY695931 BP383447 BX483457 BP383029 BP383227 BP383278 AU076856 BP383407 AU100520
GeneLoc Exon Structure
|
Expression
for MEP1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MEP1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MEP1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MEP1B
SOURCE GeneReport for Unigene cluster: Hs.194777
UniProtKB/Swiss-Prot: MEP1B_HUMAN, Q16820Tissue specificity: The major site of expression is the brush border membrane of small intestinal and kidney epithelialcells
SABiosciences Custom PCR Arrays for MEP1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEP1B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MEP1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEP1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEP1B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEP1B |
Orthologs
for MEP1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MEP1B gene from 5/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MEP1B1 |
meprin A, beta |
70.41(n)
70.56(a) |
|
421097 XM_419181.2 XP_419181.2 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.341902 |
Xenopus laevis transcribed sequence with weak similarity more |
73.16(n) |
|
BJ072498.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wu:fi19a061 |
wu:fi19a06 |
58.42(n)
60.51(a) |
|
327586 XM_003197806.1 XP_003197854.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG57153
CG66961 |
meprin A3
CG66961 |
43(a)
(best of 7)3
46.86(n)1
44.34(a)1 |
|
95F103
328561 NM_133090.11 NP_573318.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
4R79.13 |
Zinc-binding metalloprotease domain |
42(a)
(best of 8) |
|
IV(17486338-17488634) -- |
ENSEMBL Gene Tree for MEP1B (if available)
TreeFam Gene Tree for MEP1B (if available) |
Paralogs
for MEP1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MEP1B gene
- MEP1A2 ASTL2
1 SIMAP similar gene for MEP1B using alignment to 3 protein entries: MEP1B_HUMAN (see all proteins):MEP1A
MEP1B for paralogs About GeneDecksing
|
Genomic Variants
for MEP1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MEP1B (29765032 - 29800367 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MEP1B
1 CNV: 5050
Human Gene Mutation Database (HGMD): MEP1B
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEP1B |
|
Disorders
/ Diseases
for MEP1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MEP1B for disorders About GeneDecksing
OMIM gene information: 600389
OMIM disorders: --
10  diseases for MEP1B: About MalaCardsexocrine pancreatic insufficiency dentinogenesis imperfecta dentin dysplasia nephropathy
colon carcinoma pharyngitis breast cancer carcinoma
pancreatitis neuronitis
2 diseases from the University of Copenhagen DISEASES database for MEP1B:Dentin dysplasia Dentinogenesis imperfecta 1 Novoseek disease relationship for MEP1B gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cancer |
2.26 |
2 |
10190276 (1), 18478055 (1) |
Human Genome Epidemiology (HuGE) Navigator: MEP1B (1 document)
Export disorders for MEP1B gene to outside databases
|
Publications
for MEP1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MEP1B gene, integrated from 9 sources (see all 49):
(articles sorted by number of sources associating them with MEP1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively. (PubMed id 7774936)1, 3, 9 Bond J.S....Jiang W. (1995)
- Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p- aminobenzoic acid hydrolase (human meprin) alpha and beta subunits in Madin-Darby canine kidney cells. (PubMed id 9288916)1, 2, 9 Eldering J.A....Sterchi E.E. (1997)
- Human meprin beta: O-linked glycans in the intervening region of the type I membrane protein protect the C-terminal region from proteolytic cleavage and diminish its secretion. (PubMed id 12387727)1, 2, 9 Leuenberger B....Sterchi E.E. (2003)
- Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases. (PubMed id 20806899)1, 2 Hedrich J....Becker-Pauly C. (2010)
- Specific processing of tenascin-C by the metalloprote ase meprinbeta neutralizes its inhibition of cell spreading. (PubMed id 19748582)1, 2 Ambort D....Sterchi E.E. (2010)
- Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells. (PubMed id 8262185)1, 2 Dumermuth E.... Sterchi E.E. (1993)
- The metalloprotease meprinbeta processes E-cadherin and weakens intercellular adhesion. (PubMed id 18478055)2, 9 Huguenin M....Lottaz D. (2008)
- The cleavage of protein kinase A by the kinase-splitting membranal proteinase is reproduced by meprin beta. (PubMed id 8939981)1, 9 Chestukhin A....Shaltiel S. (1996)
- Critical amino acids in the active site of meprin metalloproteinases for substrate and peptide bond specificity. (PubMed id 12888571)2, 9 Villa J.P....Bond J.S. (2003)
- The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation. (PubMed id 17195012)1, 9 Becker-Pauly C....Stocker W. (2007)
|
External Searches for MEP1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MEP1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MEP1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MEP1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MEP1B gene:
Search GeneIP for patents involving MEP1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MEP1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MEP1B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEP1B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEP1B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MEP1B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEP1B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEP1B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MEP1B | | OriGene Custom Protein Services for MEP1B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MEP1B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEP1B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEP1B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEP1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEP1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEP1B |
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| | | | Search Tocris compounds for MEP1B |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEP1B |
|  |  |  | | | | ThermoFisher Antibodies for MEP1B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEP1B |
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