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Aliases for MEP1B Gene

Aliases for MEP1B Gene

  • Meprin A Subunit Beta 2 3 5
  • N-Benzoyl-L-Tyrosyl-P-Amino-Benzoic Acid Hydrolase Subunit Beta 3 4
  • PABA Peptide Hydrolase 3 4
  • Endopeptidase-2 3 4
  • Meprin A, Beta 2 3
  • Meprin B 3 4
  • PPH Beta 3 4
  • N-Benzoyl-L-Tyrosyl-P-Amino-Benzoic Acid Hydrolase Beta Subunit 3
  • EC 3.4.24.63 4

External Ids for MEP1B Gene

Previous GeneCards Identifiers for MEP1B Gene

  • GC18P029793
  • GC18P029589
  • GC18P028021
  • GC18P028023
  • GC18P026626

Summaries for MEP1B Gene

Entrez Gene Summary for MEP1B Gene

  • Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011]

GeneCards Summary for MEP1B Gene

MEP1B (Meprin A Subunit Beta) is a Protein Coding gene. Among its related pathways are Protein digestion and absorption and Activation of cAMP-Dependent PKA. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ASTL.

UniProtKB/Swiss-Prot for MEP1B Gene

  • Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1 position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components.

Gene Wiki entry for MEP1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEP1B Gene

Genomics for MEP1B Gene

Regulatory Elements for MEP1B Gene

Genomic Location for MEP1B Gene

Chromosome:
18
Start:
32,185,069 bp from pter
End:
32,220,404 bp from pter
Size:
35,336 bases
Orientation:
Plus strand

Genomic View for MEP1B Gene

Genes around MEP1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEP1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEP1B Gene

Proteins for MEP1B Gene

  • Protein details for MEP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16820-MEP1B_HUMAN
    Recommended name:
    Meprin A subunit beta
    Protein Accession:
    Q16820
    Secondary Accessions:
    • B7ZM35
    • B9EGL6
    • Q670J1

    Protein attributes for MEP1B Gene

    Size:
    701 amino acids
    Molecular mass:
    79571 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homotetramer consisting of disulfide-linked beta subunits, or heterotetramer of two alpha and two beta subunits formed by non-covalent association of two disulfide-linked heterodimers (By similarity). Interacts with MBL2 through its carbohydrate moiety. This interaction may inhibit its catalytic activity (By similarity).

    Three dimensional structures from OCA and Proteopedia for MEP1B Gene

neXtProt entry for MEP1B Gene

Proteomics data for MEP1B Gene at MOPED

Post-translational modifications for MEP1B Gene

  • N-glycosylated; contains high mannose and/or complex biantennary structures.
  • O-glycosylation protect the C-terminal region from proteolytic cleavage and diminish secretion, this seems to be specific to human.
  • Proteolytically activated by trypsin in the intestinal lumen and kallikrein-related peptidases in other tissues.
  • Glycosylation at Asn 218, Asn 254, Asn 370, Asn 421, Asn 436, Asn 445, Asn 547, Asn 592, Ser 593, Thr 594, Thr 599, and Ser 603
  • Modification sites at PhosphoSitePlus

Other Protein References for MEP1B Gene

Antibody Products

  • R&D Systems Antibodies for MEP1B (Meprin beta Subunit/MEP1B)

No data available for DME Specific Peptides for MEP1B Gene

Domains & Families for MEP1B Gene

Gene Families for MEP1B Gene

Suggested Antigen Peptide Sequences for MEP1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16820

UniProtKB/Swiss-Prot:

MEP1B_HUMAN :
  • Contains 1 EGF-like domain.
  • Belongs to the peptidase M12A family.
Domain:
  • Contains 1 EGF-like domain.
  • Contains 1 MAM domain.
  • Contains 1 MATH domain.
Family:
  • Belongs to the peptidase M12A family.
genes like me logo Genes that share domains with MEP1B: view

Function for MEP1B Gene

Molecular function for MEP1B Gene

GENATLAS Biochemistry:
zinc metalloendopeptidase 1,meprin,beta subunit,astacin family
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of 5-His- -Leu-6, 6-Leu- -Cys-7, 14-Ala- -Leu-15 and 19-Cys- -Gly-20 bonds in insulin B chain.
UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly inhibited by fetuin-A/AHSG.
UniProtKB/Swiss-Prot Function:
Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1 position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components.

Enzyme Numbers (IUBMB) for MEP1B Gene

Gene Ontology (GO) - Molecular Function for MEP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
genes like me logo Genes that share ontologies with MEP1B: view
genes like me logo Genes that share phenotypes with MEP1B: view

Animal Models for MEP1B Gene

MGI Knock Outs for MEP1B:

Animal Model Products

miRNA for MEP1B Gene

miRTarBase miRNAs that target MEP1B

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEP1B Gene

Localization for MEP1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEP1B Gene

Cell membrane; Single-pass type I membrane protein. Secreted. Note=Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17. {ECO:0000269 PubMed:22988105}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEP1B Gene COMPARTMENTS Subcellular localization image for MEP1B gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MEP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 9288916
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MEP1B: view

Pathways & Interactions for MEP1B Gene

genes like me logo Genes that share pathways with MEP1B: view

Pathways by source for MEP1B Gene

1 KEGG pathway for MEP1B Gene
1 GeneGo (Thomson Reuters) pathway for MEP1B Gene
1 Qiagen pathway for MEP1B Gene

Gene Ontology (GO) - Biological Process for MEP1B Gene

None

No data available for SIGNOR curated interactions for MEP1B Gene

Drugs & Compounds for MEP1B Gene

(1) Additional Compounds for MEP1B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MEP1B: view

Transcripts for MEP1B Gene

mRNA/cDNA for MEP1B Gene

Unigene Clusters for MEP1B Gene

Meprin A, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEP1B Gene

No ASD Table

Relevant External Links for MEP1B Gene

GeneLoc Exon Structure for
MEP1B
ECgene alternative splicing isoforms for
MEP1B

Expression for MEP1B Gene

mRNA expression in normal human tissues for MEP1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEP1B Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x47.9).

Protein differential expression in normal tissues from HIPED for MEP1B Gene

This gene is overexpressed in Pancreatic juice (65.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MEP1B Gene



SOURCE GeneReport for Unigene cluster for MEP1B Gene Hs.194777

mRNA Expression by UniProt/SwissProt for MEP1B Gene

Q16820-MEP1B_HUMAN
Tissue specificity: The major site of expression is the brush border membrane of small intestinal and kidney epithelial cells.
genes like me logo Genes that share expression patterns with MEP1B: view

Protein tissue co-expression partners for MEP1B Gene

Primer Products

In Situ Assay Products

Orthologs for MEP1B Gene

This gene was present in the common ancestor of animals.

Orthologs for MEP1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MEP1B 35
  • 82.19 (n)
  • 76.71 (a)
MEP1B 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEP1B 35
  • 87.06 (n)
  • 85.28 (a)
MEP1B 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mep1b 35
  • 80.19 (n)
  • 77.86 (a)
Mep1b 16
Mep1b 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MEP1B 35
  • 99.38 (n)
  • 99.14 (a)
MEP1B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mep1b 35
  • 80.21 (n)
  • 77.83 (a)
oppossum
(Monodelphis domestica)
Mammalia MEP1B 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEP1B 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves MEP1B 35
  • 70.34 (n)
  • 70.29 (a)
MEP1B 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEP1B 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mep1b 35
  • 64.64 (n)
  • 63.44 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.34190 35
zebrafish
(Danio rerio)
Actinopterygii si:ch73-40a17.3 35
  • 58.47 (n)
  • 60.51 (a)
mep1b 36
  • 55 (a)
OneToMany
MEP1B (2 of 2) 36
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta BG:BACR44L22.1 37
  • 35 (a)
BG:BACR44L22.2 37
  • 35 (a)
BG:BACR44L22.3 37
  • 37 (a)
BG:BACR44L22.6 37
  • 34 (a)
CG5715 37
  • 43 (a)
CG6696 37
  • 42 (a)
CG6763 37
  • 39 (a)
CG6696 35
  • 46.54 (n)
  • 44.81 (a)
CG11864 36
  • 31 (a)
ManyToMany
CG11865 36
  • 35 (a)
ManyToMany
CG15254 36
  • 34 (a)
ManyToMany
CG15255 36
  • 33 (a)
ManyToMany
CG6974 36
  • 32 (a)
ManyToMany
CG7631 36
  • 32 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010764 35
  • 50.33 (n)
  • 47.06 (a)
worm
(Caenorhabditis elegans)
Secernentea 4R79.1 37
  • 42 (a)
C05D11.6 37
  • 39 (a)
C07D10.4 37
  • 36 (a)
C34D4.9 37
  • 37 (a)
F09E8.6 37
  • 40 (a)
K04E7.3 37
  • 34 (a)
T04G9.2 37
  • 34 (a)
Y95B8A.1 37
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
Species with no ortholog for MEP1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEP1B Gene

ENSEMBL:
Gene Tree for MEP1B (if available)
TreeFam:
Gene Tree for MEP1B (if available)

Paralogs for MEP1B Gene

Paralogs for MEP1B Gene

(1) SIMAP similar genes for MEP1B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MEP1B: view

Variants for MEP1B Gene

Sequence variations from dbSNP and Humsavar for MEP1B Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs9959396 - 32,210,557(+) CAGCA(A/G)TGCTG reference, missense
rs616114 - 32,217,958(-) TTTGC(A/G)GAGTC reference, missense
VAR_069387 -
rs173032 -- 32,215,113(-) ACTTT(A/G)GAAGG reference, synonymous-codon
rs193095 -- 32,212,522(-) ACCTG(C/T)ACTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEP1B Gene

Variant ID Type Subtype PubMed ID
nsv2249 CNV Insertion 18451855
nsv833616 CNV Gain 17160897

Variation tolerance for MEP1B Gene

Residual Variation Intolerance Score: 80.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.11; 75.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEP1B Gene

HapMap Linkage Disequilibrium report
MEP1B
Human Gene Mutation Database (HGMD)
MEP1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEP1B Gene

Disorders for MEP1B Gene

Relevant External Links for MEP1B

Genetic Association Database (GAD)
MEP1B
Human Genome Epidemiology (HuGE) Navigator
MEP1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEP1B

No disorders were found for MEP1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEP1B Gene

Publications for MEP1B Gene

  1. The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively. (PMID: 7774936) Bond J.S. … Jiang W. (Genomics 1995) 2 3 23 67
  2. The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation. (PMID: 17195012) Becker-Pauly C. … StAPcker W. (J. Invest. Dermatol. 2007) 3 23
  3. Human meprin beta: O-linked glycans in the intervening region of the type I membrane protein protect the C-terminal region from proteolytic cleavage and diminish its secretion. (PMID: 12387727) Leuenberger B. … Sterchi E.E. (Biochem. J. 2003) 3 23
  4. Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p- aminobenzoic acid hydrolase (human meprin) alpha and beta subunits in Madin-Darby canine kidney cells. (PMID: 9288916) Eldering J.A. … Sterchi E.E. (Eur. J. Biochem. 1997) 3 23
  5. The cleavage of protein kinase A by the kinase-splitting membranal proteinase is reproduced by meprin beta. (PMID: 8939981) Chestukhin A. … Shaltiel S. (J. Biol. Chem. 1996) 3 23

Products for MEP1B Gene

Sources for MEP1B Gene

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