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MEP1B Gene

protein-coding   GIFtS: 64
GCID: GC18P029793

Meprin A, Beta

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Meprin A, Beta1 2     endopeptidase-22
Meprin B2 3     Meprin A Subunit Beta2
N-Benzoyl-L-Tyrosyl-P-Amino-Benzoic Acid Hydrolase Subunit Beta2 3     N-Benzoyl-L-Tyrosyl-P-Amino-Benzoic Acid Hydrolase Beta Subunit2
PABA Peptide Hydrolase2 3     EC 3.4.24.633
PPH Beta2 3     Endopeptidase-23

External Ids:    HGNC: 70201   Entrez Gene: 42252   Ensembl: ENSG000001414347   OMIM: 6003895   UniProtKB: Q168203   

Export aliases for MEP1B gene to outside databases

Previous GC identifers: GC18P029589 GC18P028021 GC18P028023 GC18P026626


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MEP1B Gene:
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush
border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of
peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins
are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of
alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene
encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene
expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. (provided
by RefSeq, Oct 2011)

GeneCards Summary for MEP1B Gene:
MEP1B (meprin A, beta) is a protein-coding gene. Diseases associated with MEP1B include dentin dysplasia, and exocrine pancreatic insufficiency. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is MEP1A.

UniProtKB/Swiss-Prot: MEP1B_HUMAN, Q16820
Function: Membrane metallopeptidase that sheds many membrane-bound proteins. Known substrates include: FGF19,
VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several
pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue
remodeling due to its capability to degrade extracellular matrix components

Gene Wiki entry for MEP1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MEP1B gene promoter:
         Nkx2-2   SREBP-1c   MyoD   MIF-1   Cdc5   SREBP-1b   SREBP-1a   SEF-1 (1)   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMEP1B promoter sequence
   Search Chromatin IP Primers for MEP1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEP1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.2-q12.3   Ensembl cytogenetic band:  18q12.1   HGNC cytogenetic band: 18q12.2-q12.3

MEP1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEP1B gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P029793:  view genomic region     (about GC identifiers)

Start:
29,765,032 bp from pter      End:
29,800,367 bp from pter
Size:
35,336 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MEP1B_HUMAN, Q16820 (See protein sequence)
Recommended Name: Meprin A subunit beta precursor  
Size: 701 amino acids; 79571 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Homotetramer consisting of disulfide-linked beta subunits, or heterotetramer of two alpha and two beta
subunits formed by non-covalent association of two disulfide-linked heterodimers (By similarity). Interacts with
MBL2 through its carbohydrate moiety. This interaction may inhibit its catalytic activity (By similarity)
2 PDB 3D structures from and Proteopedia for MEP1B:
4GWM (3D)        4GWN (3D)    
Secondary accessions: B7ZM35 B9EGL6 Q670J1

Explore the universe of human proteins at neXtProt for MEP1B: NX_Q16820

Explore proteomics data for MEP1B at MOPED

Post-translational modifications: 

  • N-glycosylated; contains high mannose and/or complex biantennary structures1
  • O-glycosylation protect the C-terminal region from proteolytic cleavage and diminish secretion, this seems to be
    specific to human1
  • Proteolytically activated by trypsin in the intestinal lumen and kallikrein-related peptidases in other tissues1
  • Glycosylation2 at Asn218, Asn254, Asn370, Asn421, Asn436, Asn445, Asn547, Asn592, Ser593, Thr594,
                                 Thr599, Ser603
  • Modification sites at PhosphoSitePlus

  • See MEP1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005916.2  
    ENSEMBL proteins: 
     ENSP00000462038   ENSP00000269202   ENSP00000463280  

    MEP1B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR008974 TRAF-like
     IPR002083 MATH
     IPR024079 MetalloPept_cat_dom
     IPR000742 EG-like_dom
     IPR001506 Peptidase_M12A

    Graphical View of Domain Structure for InterPro Entry Q16820

    ProtoNet protein and cluster: Q16820

    4 Blocks protein domains:
    IPB000998 MAM domain signature
    IPB001506 Astacin family signature
    IPB002083 Meprin/TRAF-like MATH
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: MEP1B_HUMAN, Q16820
    Similarity: Belongs to the peptidase M12A family
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 MAM domain
    Similarity: Contains 1 MATH domain


    MEP1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MEP1B_HUMAN, Q16820
    Function: Membrane metallopeptidase that sheds many membrane-bound proteins. Known substrates include: FGF19,
    VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several
    pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue
    remodeling due to its capability to degrade extracellular matrix components
    Catalytic activity: Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of 5-His- -Leu-6, 6-Leu-
    -Cys-7, 14-Ala- -Leu-15 and 19-Cys- -Gly-20 bonds in insulin B chain. Exhibits a strong preference for acidic
    amino acids at the P1' position
    Enzyme regulation: Strongly inhibited by fetuin-A/AHSG

         Genatlas biochemistry entry for MEP1B:
    zinc metalloendopeptidase 1,meprin,beta subunit,astacin family

         Enzyme Number (IUBMB): EC 3.4.24.631

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005515protein binding IPI--
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    MEP1B for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mep1b):
     growth/size/body  homeostasis/metabolism  immune system  mortality/aging  renal/urinary system 
     reproductive system 

    MEP1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mep1btm1Bond for MEP1B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MEP1B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MEP1B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MEP1B

    miRNA
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    miRTarBase miRNAs that target MEP1B:
    hsa-mir-148b-3p (MIRT019267)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MEP1B_HUMAN, Q16820: Cell membrane; Single-pass type I membrane protein. Secreted. Note=Homodimers are
    essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    endoplasmic reticulum1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS9288916
    GO:0005886plasma membrane TAS9288916
    GO:0005887integral component of plasma membrane TAS9288916
    GO:0016020membrane ----

    MEP1B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MEP1B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    cAMP Pathway0.77
    2Signal transduction PKA signaling
    Signal transduction PKA signaling
    3Protein digestion and absorption
    Protein digestion and absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MEP1B
        cAMP Pathway

    1 GeneGo (Thomson Reuters) Pathway for MEP1B
        Signal transduction PKA signaling



    1 Kegg Pathway  (Kegg details for MEP1B):
        Protein digestion and absorption


    MEP1B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MEP1B
    Interactions:

        Search GeneGlobe Interaction Network for MEP1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for MEP1B (Q168201, 2, 3 ENSP000002692024) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMP9P147801, 2EBI-968418,EBI-1382326 MINT-8399917 MINT-8399942
    FN1P027513, ENSP000003468394I2D: score=2 STRING: ENSP00000346839
    ALKQ9UM733, ENSP000003737004I2D: score=1 STRING: ENSP00000373700
    GRPP074923, ENSP000002568574I2D: score=1 STRING: ENSP00000256857
    NPYP013033, ENSP000002421524I2D: score=1 STRING: ENSP00000242152
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0006954inflammatory response IEA--
    GO:0007586digestion TAS9288916

    MEP1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MEP1B

    1 Novoseek inferred chemical compound relationship for MEP1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polysaccharide 17.9 1 12387727 (1)



    MEP1B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MEP1B gene: 
    NM_005925.2  

    Unigene Cluster for MEP1B:

    Meprin A, beta
    Hs.194777  [show with all ESTs]
    Unigene Representative Sequence: AY695931
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000581184 ENST00000269202(uc002kxj.4) ENST00000581447 ENST00000579919

    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat MEP1B

    Additional mRNA sequence: 

    AY695931.1 BC136559.1 BC144244.1 X81333.1 

    4 DOTS entries:

    DT.40255945  DT.121103370  DT.121103371  DT.97769837 

    14 AceView cDNA sequences:

    BX280186 AW951419 AA298414 NM_005925 X81333 BP383227 BP383447 AY695931 
    BP383029 BX483457 BP383278 BP383407 AU076856 AU100520 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MEP1B expression in normal human tissues (normalized intensities)      MEP1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MEP1B Expression
    About this image


    MEP1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Gonad
             Primordial Germ Cells Allantois
     
     Placenta (Extraembryonic Tissues)
             Primordial Germ Cells Allantois
     
     Kidney (Urinary System)
    MEP1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MEP1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.194777

    UniProtKB/Swiss-Prot: MEP1B_HUMAN, Q16820
    Tissue specificity: The major site of expression is the brush border membrane of small intestinal and kidney
    epithelial cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MEP1B gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mep1b1 , 5 meprin 1 beta1, 5 80.19(n)1
    77.86(a)1
      18 (11.81 cM)5
    172881  NM_008586.21  NP_032612.21 
     210723445 
    chicken
    (Gallus gallus)
    Aves MEP1B1 meprin A, beta 70.34(n)
    70.29(a)
      421097  XM_419181.3  XP_419181.3 
    lizard
    (Anolis carolinensis)
    Reptilia MEP1B6
    meprin A, beta
    63(a)
    1 ↔ 1
    GL343207.1(3385285-3408408)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.341902 Xenopus laevis transcribed sequence with weak similarity more 73.16(n)    BJ072498.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-40a17.31 si:ch73-40a17.3 58.47(n)
    60.51(a)
      327586  XM_003197806.2  XP_003197854.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG57153
    CG66961
    meprin A3
    CG66961
    43(a)
    (best of 7)3
    46.54(n)1
    44.81(a)1
      95F103
    328561  NM_133090.11  NP_573318.11 


    ENSEMBL Gene Tree for MEP1B (if available)
    TreeFam Gene Tree for MEP1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MEP1B gene
    MEP1A2  ASTL2  
    1 SIMAP similar gene for MEP1B using alignment to 3 protein entries:     MEP1B_HUMAN (see all proteins):
    MEP1A

    MEP1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MEP1B (see all 751)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1832129711,2
    --29767988(+) CACCAA/CCATGC 1 -- us2k10--------
    rs1481850081,2
    --29768054(+) GGTTGC/TGAACT 1 -- us2k10--------
    rs1890389031,2
    --29768055(+) GTTGCA/GAACTC 1 -- us2k10--------
    rs1412108681,2
    --29768150(+) TTAATC/TCATTT 1 -- us2k10--------
    rs1931406481,2
    --29768207(+) CTTCCA/GTATAT 1 -- us2k10--------
    rs1852212291,2
    --29768232(+) TCAGCG/TCCATT 1 -- us2k10--------
    rs1507320401,2
    --29768365(+) AAAAAC/TTTAAT 1 -- us2k10--------
    rs1381545151,2
    --29768391(+) ATTCAC/TATTTT 1 -- us2k10--------
    rs620956091,2
    C,F--29768448(+) GGAAGG/TTCCCT 1 -- us2k16Minor allele frequency- T:0.07WA NA CSA 246
    rs1900882831,2
    --29768481(+) CCTCAC/GAGGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MEP1B (29765032 - 29800367 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MEP1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2249CNV Insertion18451855
    nsv833616CNV Gain17160897

    Human Gene Mutation Database (HGMD): MEP1B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MEP1B
    DNA2.0 Custom Variant and Variant Library Synthesis for MEP1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600389    OMIM disorders: --

    8 diseases for MEP1B:    About MalaCards
    dentin dysplasia    exocrine pancreatic insufficiency    dentinogenesis imperfecta    diabetic nephropathy
    intellectual disability    pancreatitis    malaria    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for MEP1B:
    Dentin dysplasia     Dentinogenesis imperfecta

    MEP1B for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for MEP1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 2.26 2 10190276 (1), 18478055 (1)

    Genetic Association Database (GAD): MEP1B
    Human Genome Epidemiology (HuGE) Navigator: MEP1B (1 document)

    Export disorders for MEP1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MEP1B gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with MEP1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively. (PubMed id 7774936)1, 3, 9 Bond J.S....Jiang W. (Genomics 1995)
    2. Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p- aminobenzoic acid hydrolase (human meprin) alpha and beta subunits in Madin-Darby canine kidney cells. (PubMed id 9288916)1, 2, 9 Eldering J.A....Sterchi E.E. (Eur. J. Biochem. 1997)
    3. Human meprin beta: O-linked glycans in the intervening region of the type I membrane protein protect the C-terminal region from proteolytic cleavage and diminish its secretion. (PubMed id 12387727)1, 2, 9 Leuenberger B.... Sterchi E.E. (Biochem. J. 2003)
    4. The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin beta and ADAM10. (PubMed id 22940918)1, 2 Jefferson T.... Becker-Pauly C. (Cell. Mol. Life Sci. 2013)
    5. Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases. (PubMed id 20806899)1, 2 Hedrich J.... Becker-Pauly C. (Biochemistry 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Specific processing of tenascin-C by the metalloprotease meprinbeta neutralizes its inhibition of cell spreading. (PubMed id 19748582)1, 2 Ambort D.... Sterchi E.E. (Matrix Biol. 2010)
    8. Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells. (PubMed id 8262185)1, 2 Dumermuth E.... Sterchi E.E. (FEBS Lett. 1993)
    9. The metalloprotease meprinbeta processes E-cadherin and weakens intercellular adhesion. (PubMed id 18478055)2, 9 Huguenin M.... Lottaz D. (PLoS ONE 2008)
    10. The cleavage of protein kinase A by the kinase-splitting membranal proteinase is reproduced by meprin beta. (PubMed id 8939981)1, 9 Chestukhin A....Shaltiel S. (J. Biol. Chem. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4225 HGNC: 7020 AceView: MEP1B Ensembl:ENSG00000141434 euGenes: HUgn4225
    ECgene: MEP1B Kegg: 4225 H-InvDB: MEP1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MEP1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MEP1B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MEP1B gene:
    Search GeneIP for patents involving MEP1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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