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Aliases for MEP1B Gene

Aliases for MEP1B Gene

  • Meprin A, Beta 2 3
  • N-Benzoyl-L-Tyrosyl-P-Amino-Benzoic Acid Hydrolase Subunit Beta 3 4
  • PABA Peptide Hydrolase 3 4
  • Endopeptidase-2 3 4
  • Meprin B 3 4
  • PPH Beta 3 4
  • N-Benzoyl-L-Tyrosyl-P-Amino-Benzoic Acid Hydrolase Beta Subunit 3
  • Meprin A Subunit Beta 3
  • EC 3.4.24.63 4

External Ids for MEP1B Gene

Summaries for MEP1B Gene

Entrez Gene Summary for MEP1B Gene

  • Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011]

GeneCards Summary for MEP1B Gene

MEP1B (Meprin A, Beta) is a Protein Coding gene. Diseases associated with MEP1B include dentinogenesis imperfecta and dentin dysplasia. Among its related pathways are Activation of cAMP-Dependent PKA and Signal transduction_PKA signaling. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ASTL.

UniProtKB/Swiss-Prot for MEP1B Gene

  • Membrane metallopeptidase that sheds many membrane-bound proteins. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components.

Gene Wiki entry for MEP1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEP1B Gene

Genomics for MEP1B Gene

Genomic Location for MEP1B Gene

Start:
32,185,069 bp from pter
End:
32,220,404 bp from pter
Size:
35,336 bases
Orientation:
Plus strand

Genomic View for MEP1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEP1B Gene

Regulatory Elements for MEP1B Gene

Proteins for MEP1B Gene

  • Protein details for MEP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16820-MEP1B_HUMAN
    Recommended name:
    Meprin A subunit beta
    Protein Accession:
    Q16820
    Secondary Accessions:
    • B7ZM35
    • B9EGL6
    • Q670J1

    Protein attributes for MEP1B Gene

    Size:
    701 amino acids
    Molecular mass:
    79571 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Homotetramer consisting of disulfide-linked beta subunits, or heterotetramer of two alpha and two beta subunits formed by non-covalent association of two disulfide-linked heterodimers (By similarity). Interacts with MBL2 through its carbohydrate moiety. This interaction may inhibit its catalytic activity (By similarity).

    Three dimensional structures from OCA and Proteopedia for MEP1B Gene

neXtProt entry for MEP1B Gene

Proteomics data for MEP1B Gene at MOPED

Post-translational modifications for MEP1B Gene

  • N-glycosylated; contains high mannose and/or complex biantennary structures
  • O-glycosylation protect the C-terminal region from proteolytic cleavage and diminish secretion, this seems to be specific to human.
  • Proteolytically activated by trypsin in the intestinal lumen and kallikrein-related peptidases in other tissues
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn218, Asn254, Asn370, Asn421, Asn436, Asn445, Asn547, Asn592, Ser593, Thr594, Thr599, and Ser603

Other Protein References for MEP1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEP1B Gene

Domains for MEP1B Gene

UniProtKB/Swiss-Prot:

MEP1B_HUMAN
Domain:
  • Contains 1 EGF-like domain.:
    • Q16820
  • Contains 1 MAM domain.:
    • Q16820
  • Contains 1 MATH domain.:
    • Q16820
Family:
  • Belongs to the peptidase M12A family.:
    • Q16820
genes like me logo Genes that share domains with MEP1B: view

No data available for Gene Families for MEP1B Gene

Function for MEP1B Gene

Molecular function for MEP1B Gene

GENATLAS Biochemistry: zinc metalloendopeptidase 1,meprin,beta subunit,astacin family
UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of 5-His- -Leu-6, 6-Leu- -Cys-7, 14-Ala- -Leu-15 and 19-Cys- -Gly-20 bonds in insulin B chain. Exhibits a strong preference for acidic amino acids at the P1 position.
UniProtKB/Swiss-Prot EnzymeRegulation: Strongly inhibited by fetuin-A/AHSG.
UniProtKB/Swiss-Prot Function: Membrane metallopeptidase that sheds many membrane-bound proteins. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components.

Enzyme Numbers (IUBMB) for MEP1B Gene

Gene Ontology (GO) - Molecular Function for MEP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005515 protein binding IPI 23123160
GO:0008237 metallopeptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MEP1B: view
genes like me logo Genes that share phenotypes with MEP1B: view

Animal Models for MEP1B Gene

MGI Knock Outs for MEP1B:

miRNA for MEP1B Gene

miRTarBase miRNAs that target MEP1B

No data available for Transcription Factor Targeting and HOMER Transcription for MEP1B Gene

Localization for MEP1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEP1B Gene

Cell membrane; Single-pass type I membrane protein. Secreted. Note=Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEP1B Gene COMPARTMENTS Subcellular localization image for MEP1B gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MEP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 9288916
GO:0005886 plasma membrane TAS 9288916
GO:0005887 integral component of plasma membrane TAS 9288916
GO:0016020 membrane --
genes like me logo Genes that share ontologies with MEP1B: view

Pathways for MEP1B Gene

genes like me logo Genes that share pathways with MEP1B: view

Pathways by source for MEP1B Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for MEP1B Gene
1 Qiagen pathway for MEP1B Gene
1 KEGG pathway for MEP1B Gene

Gene Ontology (GO) - Biological Process for MEP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006954 inflammatory response IEA --
GO:0007586 digestion TAS 9288916
GO:1901998 toxin transport IEA --
genes like me logo Genes that share ontologies with MEP1B: view

Compounds for MEP1B Gene

(1) Novoseek inferred chemical compound relationships for MEP1B Gene

Compound -log(P) Hits PubMed IDs
polysaccharide 17.9 1
genes like me logo Genes that share compounds with MEP1B: view

Transcripts for MEP1B Gene

mRNA/cDNA for MEP1B Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MEP1B Gene

Meprin A, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEP1B Gene

No ASD Table

Relevant External Links for MEP1B Gene

GeneLoc Exon Structure for
MEP1B
ECgene alternative splicing isoforms for
MEP1B

Expression for MEP1B Gene

mRNA expression in normal human tissues for MEP1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEP1B Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (47.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MEP1B Gene

SOURCE GeneReport for Unigene cluster for MEP1B Gene Hs.194777

mRNA Expression by UniProt/SwissProt for MEP1B Gene

Q16820-MEP1B_HUMAN
Tissue specificity: The major site of expression is the brush border membrane of small intestinal and kidney epithelial cells.
genes like me logo Genes that share expressions with MEP1B: view

Orthologs for MEP1B Gene

This gene was present in the common ancestor of animals.

Orthologs for MEP1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEP1B 36
  • 99.38 (n)
  • 99.14 (a)
MEP1B 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MEP1B 36
  • 82.19 (n)
  • 76.71 (a)
MEP1B 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEP1B 36
  • 87.06 (n)
  • 85.28 (a)
MEP1B 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mep1b 36
  • 80.19 (n)
  • 77.86 (a)
Mep1b 16
Mep1b 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MEP1B 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEP1B 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mep1b 36
  • 80.21 (n)
  • 77.83 (a)
chicken
(Gallus gallus)
Aves MEP1B 36
  • 70.34 (n)
  • 70.29 (a)
MEP1B 37
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEP1B 37
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.34190 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mep1b 36
  • 64.64 (n)
  • 63.44 (a)
zebrafish
(Danio rerio)
Actinopterygii mep1b 37
  • 55 (a)
OneToMany
MEP1B (2 of 2) 37
  • 52 (a)
OneToMany
si:ch73-40a17.3 36
  • 58.47 (n)
  • 60.51 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010764 36
  • 50.33 (n)
  • 47.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11864 37
  • 31 (a)
ManyToMany
CG11865 37
  • 35 (a)
ManyToMany
CG15254 37
  • 34 (a)
ManyToMany
CG15255 37
  • 33 (a)
ManyToMany
CG6696 36
  • 46.54 (n)
  • 44.81 (a)
CG6974 37
  • 32 (a)
ManyToMany
CG7631 37
  • 32 (a)
ManyToMany
CG5715 38
  • 43 (a)
BG:BACR44L22.3 38
  • 37 (a)
CG6696 38
  • 42 (a)
BG:BACR44L22.1 38
  • 35 (a)
BG:BACR44L22.6 38
  • 34 (a)
BG:BACR44L22.2 38
  • 35 (a)
CG6763 38
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea T04G9.2 38
  • 34 (a)
K04E7.3 38
  • 34 (a)
Y95B8A.1 38
  • 39 (a)
C07D10.4 38
  • 36 (a)
4R79.1 38
  • 42 (a)
F09E8.6 38
  • 40 (a)
C05D11.6 38
  • 39 (a)
C34D4.9 38
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 22 (a)
ManyToMany
-- 37
  • 21 (a)
ManyToMany
Species with no ortholog for MEP1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEP1B Gene

ENSEMBL:
Gene Tree for MEP1B (if available)
TreeFam:
Gene Tree for MEP1B (if available)

Paralogs for MEP1B Gene

Paralogs for MEP1B Gene

Selected SIMAP similar genes for MEP1B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MEP1B: view

Variants for MEP1B Gene

Sequence variations from dbSNP and Humsavar for MEP1B Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs173032 -- 32,215,113(-) ACTTT(A/G)GAAGG synonymous-codon, reference
rs193095 -- 32,212,522(-) ACCTG(C/T)ACTTC intron-variant
rs233223 -- 32,215,138(-) ATTAG(A/G)GAACA missense, reference
rs335514 -- 32,215,780(-) GTGGC(A/G)CGAAC intron-variant
rs335515 -- 32,214,284(-) TGATC(A/T)TTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEP1B Gene

Variant ID Type Subtype PubMed ID
nsv2249 CNV Insertion 18451855
nsv833616 CNV Gain 17160897

Relevant External Links for MEP1B Gene

HapMap Linkage Disequilibrium report
MEP1B
Human Gene Mutation Database (HGMD)
MEP1B

Disorders for MEP1B Gene

(2) University of Copenhagen DISEASES for MEP1B Gene

(1) Novoseek inferred disease relationships for MEP1B Gene

Disease -log(P) Hits PubMed IDs
cancer 2.26 2

Relevant External Links for MEP1B

Genetic Association Database (GAD)
MEP1B
Human Genome Epidemiology (HuGE) Navigator
MEP1B
genes like me logo Genes that share disorders with MEP1B: view

No data available for UniProtKB/Swiss-Prot for MEP1B Gene

Publications for MEP1B Gene

  1. The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively. (PMID: 7774936) Bond J.S. … Jiang W. (Genomics 1995) 2 3 23
  2. Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p- aminobenzoic acid hydrolase (human meprin) alpha and beta subunits in Madin-Darby canine kidney cells. (PMID: 9288916) Eldering J.A. … Sterchi E.E. (Eur. J. Biochem. 1997) 3 4 23
  3. Human meprin beta: O-linked glycans in the intervening region of the type I membrane protein protect the C-terminal region from proteolytic cleavage and diminish its secretion. (PMID: 12387727) Leuenberger B. … Sterchi E.E. (Biochem. J. 2003) 3 4 23
  4. The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation. (PMID: 17195012) Becker-Pauly C. … StAPcker W. (J. Invest. Dermatol. 2007) 3 23
  5. Critical amino acids in the active site of meprin metalloproteinases for substrate and peptide bond specificity. (PMID: 12888571) Villa J.P. … Bond J.S. (J. Biol. Chem. 2003) 4 23

Products for MEP1B Gene

Sources for MEP1B Gene

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