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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MEP1A Gene

protein-coding   GIFtS: 63
GCID: GC06P046807

meprin A, alpha (PABA peptide hydrolase)
 Explore 9 diseases affiliated with
MEP1A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MEP1A    

Aliases
for MEP1A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Meprin A, Alpha (PABA Peptide Hydrolase)1 2     BA268F1.1 (Meprin A Alpha (PABA Peptide Hydrolase))2
PPHA1 2     Endopeptidase-23
N-Benzoyl-L-Tyrosyl-P-Amino-Benzoic Acid Hydrolase Subunit Alpha2 3     Meprin A Subunit Alpha2
PABA Peptide Hydrolase2 3     Endopeptidase-23
PPH Alpha2 3     EC 3.4.248
EC 3.4.24.183 8     

External Ids:    HGNC: 70151   Entrez Gene: 42242   Ensembl: ENSG000001128187   OMIM: 6003885   UniProtKB: Q168193   

Export aliases for MEP1A gene to outside databases

Previous GC identifers: GC06U990080 GC06P046757 GC06P046869 GC06P046484


Summaries
for MEP1A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Gene Wiki entry for MEP1A


Genomic Views
for MEP1A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MEP1A gene promoter:
         STAT1   AML1a   Lmo2   AP-4   HNF-4alpha2   E4BP4   HNF-4alpha1   PPAR-gamma1   S8   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MEP1A promoter sequence
   Search SABiosciences Chromatin IP Primers for MEP1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEP1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12-p11   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p12-p11

MEP1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEP1A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P046807:  view genomic region     (about GC identifiers)

Start:
 46,761,094 bp from pter      End:
 46,807,519 bp from pter
Size:
 46,426 bases      Orientation:
 plus strand

Proteins
for MEP1A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MEP1A_HUMAN, Q16819 (See protein sequence)
Recommended Name: Meprin A subunit alpha precursor  
Size: 746 amino acids; 84419 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Homotetramer consisting of disulfide-linked alpha subunits, homooligomer consisting of disulfide-linked alpha
subunit homodimers, or heterotetramer of two alpha and two beta subunits formed by non-covalent association of two
disulfide-linked heterodimers (By similarity). Interacts with MBL2 through its carbohydrate moiety. This interaction
may inhibit its catalytic activity (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: A2RRM4 B0AZP9 B2RCS2 Q8TDC9 Q9H1R1

Explore the universe of human proteins at neXtProt for MEP1A: NX_Q16819

Post-translational modifications:

  • N-glycosylated; contains GlcNAc, galactose, mannose and a small amount of fucose (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16819

    • 3 DME Specific Peptides for MEP1A (Q16819)
     LNTPYDY  SRTDRDD  HEILHALGF 

    MEP1A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005579.2  
    ENSEMBL proteins: 
     ENSP00000230588  

    Human Recombinant Protein Products: 
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    Sino Biological Recombinant Protein for MEP1A
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS8262185
    GO:0005624membrane fraction ----
    GO:0005625soluble fraction ----
    GO:0005887integral to plasma membrane TAS8262185
    GO:0017090meprin A complex IEA--


    MEP1A for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for MEP1A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MEP1A for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR008974 TRAF-like
     IPR002083 MATH
     IPR024079 MetalloPept_cat_dom
     IPR000742 EG-like_dom
     IPR001506 Peptidase_M12A

    Graphical View of Domain Structure for InterPro Entry Q16819

    ProtoNet protein and cluster: Q16819

    4 Blocks protein families:
    IPB000998 MAM domain signature
    IPB001506 Astacin family signature
    IPB002083 Meprin/TRAF-like MATH
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: MEP1A_HUMAN, Q16819
    Similarity: Belongs to the peptidase M12A family
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 MAM domain
    Similarity: Contains 1 MATH domain


    Function
    for MEP1A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MEP1A_HUMAN, Q16819
    Catalytic activity: Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic
    residues
    Enzyme regulation: Inhibited by several hydroxamate compounds, the most potent inhibitor is actinonin
    Biophysicochemical properties: Kinetic parameters: KM=110 uM for GRP; KM=18.0 uM for PTH 12-34; KM=33.9 uM for
    secretin; KM=41.3 uM for substance P; KM=56.5 uM for LHRH; KM=73.2 uM for orcokinin; KM=292 uM for alpha-MSH; KM=125
    uM for bradykinin; KM=200 uM for gastrin;

         Genatlas biochemistry entry for MEP1A:
    zinc metalloendopeptidase 1,meprin,alpha subunit,astacin family of metalloendopeptidases

    Enzyme Numbers (IUBMB): EC 3.4.24.181 2 EC 3.4.242

    miRNA
    Products:            		 OriGene 3'-UTR Clone: MEP1A
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEP1A
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MEP1A:
    hsa-miR-27b* hsa-miR-1298 hsa-miR-1909*
    SwitchGear 3'UTR luciferase reporter plasmid: MEP1A 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEP1A (see all 7)
    OriGene shRNA RFP: MEP1A
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEP1A

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MEP1A

    Clone
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    GenScript: all cDNA clones in your preferred vector: MEP1A (NM_005588)
    Sino Biological Human cDNA Clone for MEP1A
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEP1A 

    Cell Line
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    Search LifeMap BioReagents cell lines for MEP1A

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEP1A

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008270zinc ion binding IEA--


    MEP1A for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Mep1atm1Bond for MEP1A
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mep1a):
     digestive/alimentary  homeostasis/metabolism  immune system  renal/urinary system  reproductive system 

    MEP1A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MEP1A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Protein digestion and absorption
    		Protein digestion and absorption1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for MEP1A):
        Protein digestion and absorption


    MEP1A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MEP1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/21 Interacting proteins for MEP1A (Q168192, 3 ENSP000002305884) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FN1P027513, ENSP000003468394I2D: score=2 STRING: ENSP00000346839
    GNRH1P011483, ENSP000002764144I2D: score=2 STRING: ENSP00000276414
    LAMA1P253913, ENSP000003743094I2D: score=2 STRING: ENSP00000374309
    LAMA5O152303, ENSP000002529994I2D: score=2 STRING: ENSP00000252999
    PTHP012703, ENSP000002820914I2D: score=2 STRING: ENSP00000282091
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0007586digestion TAS9288916


    MEP1A for ontologies           About GeneDecksing



    Drugs & Compounds
    for MEP1A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MEP1A
    Search CenterWatch for drugs/clinical trials and news about MEP1A 

    Transcripts
    for MEP1A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MEP1A gene: 
    NM_005588.2  

    Unigene Cluster for MEP1A:

    Meprin A, alpha (PABA peptide hydrolase)
    Hs.179704  [show with all ESTs]
    Unigene Representative Sequence: NM_005588
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000230588(uc010jzh.1 uc011dwg.1 uc011dwh.1 uc011dwi.1)


    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MEP1A:
    hsa-miR-27b* hsa-miR-1298 hsa-miR-1909*
    SwitchGear 3'UTR luciferase reporter plasmid: MEP1A 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEP1A (see all 7)
    OriGene shRNA RFP: MEP1A
    OriGene siRNA: MEP1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEP1A
    Clone
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    GenScript: all cDNA clones in your preferred vector: MEP1A (NM_005588)
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MEP1A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEP1A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEP1A

    Additional cDNA sequence: 

    AF478685.1 AK225212.1 AK290282.1 AK315246.1 AK315840.1 BC131714.1 BC143649.1 BC143650.1 
    BC143651.1 M82962.1 

    3 DOTS entries:

    DT.410716  DT.121324049  DT.121324050 

    24/43 AceView cDNA sequences (see all 43):

    AF478685 BP382978 CA307685 CD620872 M82962 AI700401 BP382836 BP382906 
    BP383146 BP383037 NM_005588 BM053025 BM768857 BX505878 BP383356 BM052748 
    AA452530 BP383089 BP382863 BP382854 BP383033 T28210 BX480476 BP382821 

    GeneLoc Exon Structure


    Expression
    for MEP1A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MEP1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTGGCACAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MEP1A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    Gut TubeMidgutGut Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MEP1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MEP1A

    SOURCE GeneReport for Unigene cluster: Hs.179704
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    In Situ
    Assay Products:     
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    Orthologs
    for MEP1A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MEP1A gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mep1a1 , 5 meprin 1 alpha1, 5 80.46(n)1
    76.64(a)1    		   17 (19.73 cM)5
    172871  NM_008585.21  NP_032611.21 
     434743245 
    chicken
    (Gallus gallus)    		 Aves MEP1A1 meprin A, alpha (PABA peptide hydrolase) 67.67(n)
    67.48(a)    		   422060  XM_420065.3  XP_420065.2 
    lizard
    (Anolis carolinensis)    		 Reptilia MEP1A6
    --
    (see all 4)    		 --
    		 52(a)
    51(a)
    (see all 4)    		 possible ortholog
    possible ortholog
    (see all 4)    		 1(138435880-138457155)
    1(138465608-138485099)
    zebrafish
    (Danio rerio)    		 Actinopterygii mep1a.21 meprin A, alpha.2 61.18(n)
    56.97(a)    		   565535  NM_001128727.1  NP_001122199.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG66963 meprin A 37(a)
    (best of 3)    		   17D1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea T04G9.23 zinc metalloprotease 38(a)
    (best of 5)    		   X(811505-815543)   --


    ENSEMBL Gene Tree for MEP1A (if available)
    TreeFam Gene Tree for MEP1A (if available) 

    Paralogs
    for MEP1A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MEP1A gene
    MEP1B2  ASTL2  
    1 SIMAP similar gene for MEP1A using alignment to 2 protein entries:     MEP1A_HUMAN (see all proteins):
    MEP1B

    MEP1A for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for MEP1A
    PGOHUM00000236074 PGOHUM00000236202 PGOHUM00000236516 PGOHUM00000236527


    Genomic Variants
    for MEP1A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/942 NCBI SNPs in MEP1A are shown (see all 942)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs353223771,2
    		C--46525002(+) TTTTT-/TTTTTG 1 -- int12Minor allele frequency- T:0.25NA 4
    rs793220631,2
    		C,F,--46759095(+) CCCATC/TAGAAG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1853246301,2
    		--46759104(+) AGCAGA/GCCCCC 1 -- us2k10--------
    rs1898086351,2
    		--46759121(+) CATGCC/GTCCTA 1 -- us2k10--------
    rs762816601,2
    		C,F,--46759219(+) GCCCAG/ATAGTA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1120218541,2
    		--46759220(+) CCCAGT/CAGTAA 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    rs1151191501,2
    		F,--46759303(+) AGGCAA/CGAATA 1 -- us2k11Minor allele frequency- C:0.11WA 118
    rs573628021,2
    		C,--46759315(+) GTGGGT/CGTGTG 1 -- us2k14Minor allele frequency- C:0.08WA NA EA 360
    rs1142221671,2
    		F,--46759343(+) GCTGGC/TGCAGA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1502048401,2
    		--46759431(+) ATCAAC/TAAACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MEP1A (46761094 - 46807519 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for MEP1A
         4 CNVs: 31287 3611 64496 99527

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for MEP1A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MEP1A for disorders           About GeneDecksing

    OMIM gene information: 600388    OMIM disorders: --

    9 diseases for MEP1A:    About MalaCards
    vertebrobasilar insufficiency    juvenile myoclonic epilepsy    dentinogenesis imperfecta    arteriovenous malformation
    dentin dysplasia    carotid stenosis    inflammatory bowel disease    migraine
    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for MEP1A:
    Dentin dysplasia
    Genetic Association Database (GAD): MEP1A
    Human Genome Epidemiology (HuGE) Navigator: MEP1A (2 documents)

    Export disorders for MEP1A gene to outside databases

    Publications
    for MEP1A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MEP1A gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with MEP1A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively. (PubMed id 7774936)1, 3, 9 Bond J.S....Jiang W. (1995)
    2. Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells. (PubMed id 8262185)1, 2, 9 Dumermuth E.... Sterchi E.E. (1993)
    3. Exclusion of the juvenile myoclonic epilepsy gene EFHC1 as the cause of migraine on chromosome 6, but association to two rare polymorphisms in MEP1A and RHAG. (PubMed id 16378686)1, 4 Norberg A....Holmberg M. (2006)
    4. MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease. (PubMed id 19262505)1, 9 Banerjee S....Bond J.S. (2009)
    5. Structure and expression of the human MEP1A gene encoding the alpha subunit of metalloendopeptidase meprin A. (PubMed id 10898933)1, 9 Jiang W. and Le B. (2000)
    6. Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p- aminobenzoic acid hydrolase (human meprin) alpha and beta subunits in Madin-Darby canine kidney cells. (PubMed id 9288916)1, 9 Eldering J.A....Sterchi E.E. (1997)
    7. Meprina transactivates the epidermal growth factor rec eptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proli feration and migration. (PubMed id 22923609)1 Minder P....Sterchi E.E. (2012)
    8. TNF-a-induced down-regulation of CDX2 suppresses MEP1A expression in colitis. (PubMed id 22326557)1 Coskun M....Troelsen J.T. (2012)
    9. Enhanced activity of meprin-a, a pro-migratory and pro -angiogenic protease, in colorectal cancer. (PubMed id 22096485)1 Lottaz D....Sterchi E.E. (2011)
    10. Processing of procollagen III by meprins: new players in extracellular matrix assembly? (PubMed id 20631730)1 Kronenberg D....Becker-Pauly C. (2010)

    External Searches for MEP1A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing MEP1A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4224 HGNC: 7015 AceView: MEP1A Ensembl:ENSG00000112818 euGenes: HUgn4224
    ECgene: MEP1A Kegg: 4224 H-InvDB: MEP1A

    Other Databases showing MEP1A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MEP1A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MEP1A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MEP1A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MEP1A gene:
    Search GeneIP for patents involving MEP1A

    GeneCards and IP:
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