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MEP1A Gene

protein-coding   GIFtS: 64
GCID: GC06P046807

Meprin A, Alpha (PABA Peptide Hydrolase)

  See MEP1A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Meprin A, Alpha (PABA Peptide Hydrolase)1 2     BA268F1.1 (Meprin A Alpha (PABA Peptide Hydrolase))2
N-Benzoyl-L-Tyrosyl-P-Amino-Benzoic Acid Hydrolase Subunit Alpha2 3     endopeptidase-22
PABA Peptide Hydrolase2 3     Meprin A Subunit Alpha2
PPH Alpha2 3     Endopeptidase-23
EC 3.4.24.183 8     EC 3.4.248
PPHA2     

External Ids:    HGNC: 70151   Entrez Gene: 42242   Ensembl: ENSG000001128187   OMIM: 6003885   UniProtKB: Q168193   

Export aliases for MEP1A gene to outside databases

Previous GC identifers: GC06U990080 GC06P046757 GC06P046869 GC06P046484


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MEP1A Gene:
MEP1A (meprin A, alpha (PABA peptide hydrolase)) is a protein-coding gene. Diseases associated with MEP1A include dentin dysplasia, and juvenile myoclonic epilepsy. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is MEP1B.

Gene Wiki entry for MEP1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MEP1A gene promoter:
         STAT1   AML1a   Lmo2   AP-4   HNF-4alpha2   E4BP4   HNF-4alpha1   PPAR-gamma1   S8   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMEP1A promoter sequence
   Search Chromatin IP Primers for MEP1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEP1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12-p11   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p12-p11

MEP1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEP1A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P046807:  view genomic region     (about GC identifiers)

Start:
46,761,094 bp from pter      End:
46,807,519 bp from pter
Size:
46,426 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MEP1A_HUMAN, Q16819 (See protein sequence)
Recommended Name: Meprin A subunit alpha precursor  
Size: 746 amino acids; 84419 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Homotetramer consisting of disulfide-linked alpha subunits, homooligomer consisting of disulfide-linked
alpha subunit homodimers, or heterotetramer of two alpha and two beta subunits formed by non-covalent association
of two disulfide-linked heterodimers (By similarity). Interacts with MBL2 through its carbohydrate moiety. This
interaction may inhibit its catalytic activity (By similarity)
Secondary accessions: A2RRM4 B0AZP9 B2RCS2 Q8TDC9 Q9H1R1

Explore the universe of human proteins at neXtProt for MEP1A: NX_Q16819

Explore proteomics data for MEP1A at MOPED

Post-translational modifications: 

  • N-glycosylated; contains GlcNAc, galactose, mannose and a small amount of fucose (By similarity)1
  • Glycosylation2 at Asn140, Asn222, Asn258, Asn414, Asn440, Asn447, Asn539
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for MEP1A (Q16819)
     LNTPYDY  SRTDRDD  HEILHALGF 


    See MEP1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005579.2  
    ENSEMBL proteins: 
     ENSP00000230588  

    MEP1A Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for MEP1A
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    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for MEP1A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR008974 TRAF-like
     IPR002083 MATH
     IPR024079 MetalloPept_cat_dom
     IPR000742 EG-like_dom
     IPR001506 Peptidase_M12A

    Graphical View of Domain Structure for InterPro Entry Q16819

    ProtoNet protein and cluster: Q16819

    4 Blocks protein domains:
    IPB000998 MAM domain signature
    IPB001506 Astacin family signature
    IPB002083 Meprin/TRAF-like MATH
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: MEP1A_HUMAN, Q16819
    Similarity: Belongs to the peptidase M12A family
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 MAM domain
    Similarity: Contains 1 MATH domain


    Find genes that share domains with MEP1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MEP1A_HUMAN, Q16819
    Catalytic activity: Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic
    residues
    Enzyme regulation: Inhibited by several hydroxamate compounds, the most potent inhibitor is actinonin
    Biophysicochemical properties: Kinetic parameters: KM=110 uM for GRP; KM=18.0 uM for PTH 12-34; KM=33.9 uM for
    secretin; KM=41.3 uM for substance P; KM=56.5 uM for LHRH; KM=73.2 uM for orcokinin; KM=292 uM for alpha-MSH;
    KM=125 uM for bradykinin; KM=200 uM for gastrin;

         Genatlas biochemistry entry for MEP1A:
    zinc metalloendopeptidase 1,meprin,alpha subunit,astacin family of metalloendopeptidases

         Enzyme Numbers (IUBMB): EC 3.4.24.181 2 EC 3.4.242

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005515protein binding IPI--
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with MEP1A           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mep1a):
     digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system  renal/urinary system 
     reproductive system 

    Find genes that share phenotypes with MEP1A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mep1atm1Bond for MEP1A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MEP1A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MEP1A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MEP1A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MEP1A

    miRNA
    Products:
        
    miRTarBase miRNAs that target MEP1A:
    hsa-mir-26b-5p (MIRT028824)

    Block miRNA regulation of human, mouse, rat MEP1A using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate MEP1A:
    hsa-miR-27b* hsa-miR-1298 hsa-miR-1909*
    SwitchGear 3'UTR luciferase reporter plasmidMEP1A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MEP1A
    Predesigned siRNA for gene silencing in human, mouse, rat MEP1A

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: MEP1A (NM_005588)
    Sino Biological Human cDNA Clone for MEP1A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEP1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEP1A

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEP1A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MEP1A_HUMAN, Q16819: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    plasma membrane4
    endoplasmic reticulum1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS8262185
    GO:0005887integral component of plasma membrane TAS8262185
    GO:0016020membrane ----
    GO:0017090meprin A complex IEA--
    GO:0070062extracellular vesicular exosome IDA11487543

    Find genes that share ontologies with MEP1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MEP1A About    
    See pathways by source

    SuperPathContained pathways About
    1Protein digestion and absorption
    Protein digestion and absorption


    Find genes that share SuperPaths with MEP1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for MEP1A):
        Protein digestion and absorption

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MEP1A
    Interactions:

        Search GeneGlobe Interaction Network for MEP1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for MEP1A (Q168191, 2, 3 ENSP000002305884) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMP9P147801, 2EBI-8153734,EBI-1382326 MINT-8399907 MINT-8399930
    FN1P027513, ENSP000003468394I2D: score=2 STRING: ENSP00000346839
    GNRH1P011483, ENSP000002764144I2D: score=2 STRING: ENSP00000276414
    LAMA1P253913, ENSP000003743094I2D: score=2 STRING: ENSP00000374309
    LAMA5O152303, ENSP000002529994I2D: score=2 STRING: ENSP00000252999
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007586digestion TAS9288916

    Find genes that share ontologies with MEP1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MEP1A



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MEP1A gene: 
    NM_005588.2  

    Unigene Cluster for MEP1A:

    Meprin A, alpha (PABA peptide hydrolase)
    Hs.179704  [show with all ESTs]
    Unigene Representative Sequence: NM_005588
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000230588(uc010jzh.1 uc011dwg.1 uc011dwh.1 uc011dwi.1)

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate MEP1A:
    hsa-miR-27b* hsa-miR-1298 hsa-miR-1909*
    SwitchGear 3'UTR luciferase reporter plasmidMEP1A 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MEP1A
      QuantiTect SYBR Green Assays in human, mouse, rat MEP1A
      QuantiFast Probe-based Assays in human, mouse, rat MEP1A

    Additional mRNA sequence: 

    AF478685.1 AK225212.1 AK290282.1 AK315246.1 AK315840.1 BC131714.1 BC143649.1 BC143650.1 
    BC143651.1 M82962.1 

    4 DOTS entries:

    DT.410716  DT.121324049  DT.121324050  DT.99958836 

    Selected AceView cDNA sequences (see all 43):

    AF478685 NM_005588 BX505878 M82962 CD620872 BP382906 CA307685 BP383356 
    BP383037 BM053025 BP382836 BP383146 BM768857 BP382978 AI700401 T28210 
    BP383257 BM052748 BP383098 AA452530 BP383089 BP382863 BX480476 D25915 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MEP1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGCACAT
    MEP1A Expression
    About this image


    MEP1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Gut Tube (Gastrointestinal Tract)
             Midgut
     
     Liver (Hepatobiliary System)
             Hepatocyte-like cells
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced embryoid bodies
    MEP1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MEP1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.179704
        Custom PCR Arrays for MEP1A
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEP1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MEP1A gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mep1a1 , 5 meprin 1 alpha1, 5 79.88(n)1
    75.54(a)1
      17 (19.73 cM)5
    172871  NM_008585.21  NP_032611.21 
     434743245 
    chicken
    (Gallus gallus)
    Aves MEP1A1 meprin A, alpha (PABA peptide hydrolase) 67.57(n)
    67.28(a)
      422060  NM_001277721.1  NP_001264650.1 
    lizard
    (Anolis carolinensis)
    Reptilia MEP1A6
    meprin A, alpha (PABA peptide hydrolase)
    53(a)
    1 ↔ 1
    1(138435880-138457155)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mep1a1 meprin A, alpha (PABA peptide hydrolase) 64.5(n)
    62.28(a)
      548484  NM_001015767.1  NP_001015767.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mep1a.21 meprin A, alpha, tandem duplicate 2 61.47(n)
    57.5(a)
      565535  NM_001128727.1  NP_001122199.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG66963 meprin A 37(a)
    (best of 3)
      17D1   --


    ENSEMBL Gene Tree for MEP1A (if available)
    TreeFam Gene Tree for MEP1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MEP1A gene
    MEP1B2  ASTL2  
    1 SIMAP similar gene for MEP1A using alignment to 2 protein entries:     MEP1A_HUMAN (see all proteins):
    MEP1B

    Find genes that share paralogs with MEP1A           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for MEP1A
    PGOHUM00000236074 PGOHUM00000236202 PGOHUM00000236516 PGOHUM00000236527


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MEP1A (see all 1161)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs793220631,2
    C,F--46759095(+) CCCATC/TAGAAG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1853246301,2
    --46759104(+) AGCAGA/GCCCCC 1 -- us2k10--------
    rs1898086351,2
    --46759121(+) CATGCC/GTCCTA 1 -- us2k10--------
    rs762816601,2
    C,F--46759219(+) GCCCAG/ATAGTA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1120218541,2
    C,F--46759220(+) CCCAGT/CAGTAA 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    rs1151191501,2
    C,F--46759303(+) AGGCAA/CGAATA 1 -- us2k11Minor allele frequency- C:0.11WA 118
    rs573628021,2
    C--46759315(+) GTGGGT/CGTGTG 1 -- us2k14Minor allele frequency- C:0.08WA NA EA 360
    rs1142221671,2
    C,F--46759343(+) GCTGGC/TGCAGA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1502048401,2
    --46759431(+) ATCAAC/TAAACA 1 -- us2k10--------
    rs13289591,2
    C,F,A,H--46759450(-) ACCAAG/ACCTTT 1 -- us2k116Minor allele frequency- A:0.21NS EA NA WA 932

    HapMap Linkage Disequilibrium report for MEP1A (46761094 - 46807519 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for MEP1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2535765CNV Deletion19546169
    esv1387664CNV Deletion17803354
    nsv823683CNV Gain20364138
    nsv428147CNV Gain18775914
    nsv7895CNV Gain18304495
    nsv823684CNV Gain20364138
    esv24845CNV Gain19812545
    nsv830654CNV Gain17160897
    nsv885868CNV Gain21882294
    dgv1948e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): MEP1A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MEP1A
    DNA2.0 Custom Variant and Variant Library Synthesis for MEP1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600388    OMIM disorders: --

    2 diseases for MEP1A:    
    About MalaCards
    dentin dysplasia    juvenile myoclonic epilepsy

    1 disease from the University of Copenhagen DISEASES database for MEP1A:
    Dentin dysplasia

    Find genes that share disorders with MEP1A           About GenesLikeMe

    Genetic Association Database (GAD): MEP1A
    Human Genome Epidemiology (HuGE) Navigator: MEP1A (2 documents)

    Export disorders for MEP1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MEP1A gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with MEP1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease. (PubMed id 19262505)1, 4, 9 Banerjee S....Bond J.S. (Mucosal Immunol 2009)
    2. The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively. (PubMed id 7774936)1, 3, 9 Bond J.S....Jiang W. (Genomics 1995)
    3. Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells. (PubMed id 8262185)1, 2, 9 Dumermuth E.... Sterchi E.E. (FEBS Lett. 1993)
    4. Exclusion of the juvenile myoclonic epilepsy gene EFHC1 as the cause of migraine on chromosome 6, but association to two rare polymorphisms in MEP1A and RHAG. (PubMed id 16378686)1, 4 Norberg A....Holmberg M. (Neurosci. Lett. 2006)
    5. Structure and expression of the human MEP1A gene encoding the alpha subunit of metalloendopeptidase meprin A. (PubMed id 10898933)1, 9 Jiang W. and Le B. (Arch. Biochem. Biophys. 2000)
    6. Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p- aminobenzoic acid hydrolase (human meprin) alpha and beta subunits in Madin-Darby canine kidney cells. (PubMed id 9288916)1, 9 Eldering J.A....Sterchi E.E. (Eur. J. Biochem. 1997)
    7. MeprinI+ transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration. (PubMed id 22923609)1 Minder P....Sterchi E.E. (J. Biol. Chem. 2012)
    8. TNF-I+-induced down-regulation of CDX2 suppresses MEP1A expression in colitis. (PubMed id 22326557)1 Coskun M....Troelsen J.T. (Biochim. Biophys. Acta 2012)
    9. Enhanced activity of meprin-I+, a pro-migratory and pro-angiogenic protease, in colorectal cancer. (PubMed id 22096485)1 Lottaz D....Sterchi E.E. (PLoS ONE 2011)
    10. Processing of procollagen III by meprins: new players in extracellular matrix assembly? (PubMed id 20631730)1 Kronenberg D....Becker-Pauly C. (J. Invest. Dermatol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 4224 HGNC: 7015 AceView: MEP1A Ensembl:ENSG00000112818 euGenes: HUgn4224
    ECgene: MEP1A Kegg: 4224 H-InvDB: MEP1A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MEP1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MEP1A gene:
    Search GeneIP for patents involving MEP1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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