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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MEP1A Gene

protein-coding   GIFtS: 62
GCID: GC06P046807

Meprin A, Alpha (PABA Peptide Hydrolase)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Meprin A, Alpha (PABA Peptide Hydrolase)1 2     BA268F1.1 (Meprin A Alpha (PABA Peptide Hydrolase))2
N-Benzoyl-L-Tyrosyl-P-Amino-Benzoic Acid Hydrolase Subunit Alpha2 3     endopeptidase-22
PABA Peptide Hydrolase2 3     Meprin A Subunit Alpha2
PPH Alpha2 3     Endopeptidase-23
EC 3.4.24.183 8     EC 3.4.248
PPHA2     

External Ids:    HGNC: 70151   Entrez Gene: 42242   Ensembl: ENSG000001128187   OMIM: 6003885   UniProtKB: Q168193   

Export aliases for MEP1A gene to outside databases

Previous GC identifers: GC06U990080 GC06P046757 GC06P046869 GC06P046484


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MEP1A Gene: 
MEP1A (meprin A, alpha (PABA peptide hydrolase)) is a protein-coding gene. Diseases associated with MEP1A include vertebrobasilar insufficiency, and dentin dysplasia. GO annotations related to this gene include metalloendopeptidase activity and zinc ion binding. An important paralog of this gene is MEP1B.

Gene Wiki entry for MEP1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MEP1A gene promoter:
         STAT1   AML1a   Lmo2   AP-4   HNF-4alpha2   E4BP4   HNF-4alpha1   PPAR-gamma1   S8   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMEP1A promoter sequence
   Search SABiosciences Chromatin IP Primers for MEP1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEP1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12-p11   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p12-p11

MEP1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEP1A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P046807:  view genomic region     (about GC identifiers)

Start:
46,761,094 bp from pter      End:
46,807,519 bp from pter
Size:
46,426 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MEP1A_HUMAN, Q16819 (See protein sequence)
Recommended Name: Meprin A subunit alpha precursor  
Size: 746 amino acids; 84419 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Homotetramer consisting of disulfide-linked alpha subunits, homooligomer consisting of disulfide-linked
alpha subunit homodimers, or heterotetramer of two alpha and two beta subunits formed by non-covalent association
of two disulfide-linked heterodimers (By similarity). Interacts with MBL2 through its carbohydrate moiety. This
interaction may inhibit its catalytic activity (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: A2RRM4 B0AZP9 B2RCS2 Q8TDC9 Q9H1R1

Explore the universe of human proteins at neXtProt for MEP1A: NX_Q16819

Explore proteomics data for MEP1A at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated; contains GlcNAc, galactose, mannose and a small amount of fucose (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16819

  • 3 DME Specific Peptides for MEP1A (Q16819)
     LNTPYDY  SRTDRDD  HEILHALGF 

    MEP1A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MEP1A Protein Expression
    REFSEQ proteins: NP_005579.2  
    ENSEMBL proteins: 
     ENSP00000230588  

    Human Recombinant Protein Products for MEP1A: 
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    Sino Biological Cell Lysate for MEP1A 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS8262185
    GO:0005887integral to plasma membrane TAS8262185
    GO:0016020membrane ----
    GO:0017090meprin A complex IEA--

    MEP1A for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for MEP1A 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/9 InterPro protein domains (see all 9):
     IPR008974 TRAF-like
     IPR002083 MATH
     IPR024079 MetalloPept_cat_dom
     IPR000742 EG-like_dom
     IPR001506 Peptidase_M12A

    Graphical View of Domain Structure for InterPro Entry Q16819

    ProtoNet protein and cluster: Q16819

    4 Blocks protein domains:
    IPB000998 MAM domain signature
    IPB001506 Astacin family signature
    IPB002083 Meprin/TRAF-like MATH
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: MEP1A_HUMAN, Q16819
    Similarity: Belongs to the peptidase M12A family
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 MAM domain
    Similarity: Contains 1 MATH domain


    MEP1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MEP1A_HUMAN, Q16819
    Catalytic activity: Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic
    residues
    Enzyme regulation: Inhibited by several hydroxamate compounds, the most potent inhibitor is actinonin
    Biophysicochemical properties: Kinetic parameters: KM=110 uM for GRP; KM=18.0 uM for PTH 12-34; KM=33.9 uM for
    secretin; KM=41.3 uM for substance P; KM=56.5 uM for LHRH; KM=73.2 uM for orcokinin; KM=292 uM for alpha-MSH;
    KM=125 uM for bradykinin; KM=200 uM for gastrin;

         Genatlas biochemistry entry for MEP1A:
    zinc metalloendopeptidase 1,meprin,alpha subunit,astacin family of metalloendopeptidases

         Enzyme Numbers (IUBMB): EC 3.4.24.181 2 EC 3.4.242

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005515protein binding IPI--
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    MEP1A for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mep1a):
     digestive/alimentary  homeostasis/metabolism  immune system  renal/urinary system  reproductive system 

    MEP1A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mep1atm1Bond for MEP1A

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MEP1A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MEP1A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MEP1A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MEP1A 

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MEP1A:
    hsa-miR-27b* hsa-miR-1298 hsa-miR-1909*
    SwitchGear 3'UTR luciferase reporter plasmidMEP1A 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEP1A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MEP1A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Protein digestion and absorption
    Protein digestion and absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for MEP1A):
        Protein digestion and absorption


    MEP1A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MEP1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/21 Interacting proteins for MEP1A (Q168192, 3 ENSP000002305884) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FN1P027513, ENSP000003468394I2D: score=2 STRING: ENSP00000346839
    GNRH1P011483, ENSP000002764144I2D: score=2 STRING: ENSP00000276414
    LAMA1P253913, ENSP000003743094I2D: score=2 STRING: ENSP00000374309
    LAMA5O152303, ENSP000002529994I2D: score=2 STRING: ENSP00000252999
    PTHP012703, ENSP000002820914I2D: score=2 STRING: ENSP00000282091
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0007586digestion TAS9288916

    MEP1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MEP1A

    Search CenterWatch for drugs/clinical trials and news about MEP1A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MEP1A gene: 
    NM_005588.2  

    Unigene Cluster for MEP1A:

    Meprin A, alpha (PABA peptide hydrolase)
    Hs.179704  [show with all ESTs]
    Unigene Representative Sequence: NM_005588
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000230588(uc010jzh.1 uc011dwg.1 uc011dwh.1 uc011dwi.1)

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MEP1A:
    hsa-miR-27b* hsa-miR-1298 hsa-miR-1909*
    SwitchGear 3'UTR luciferase reporter plasmidMEP1A 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEP1A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEP1A

    Additional mRNA sequence: 

    AF478685.1 AK225212.1 AK290282.1 AK315246.1 AK315840.1 BC131714.1 BC143649.1 BC143650.1 
    BC143651.1 M82962.1 

    4 DOTS entries:

    DT.410716  DT.121324049  DT.121324050  DT.99958836 

    24/43 AceView cDNA sequences (see all 43):

    AF478685 M82962 BM053025 BP382836 AI700401 CD620872 BP382978 NM_005588 
    BP383356 BP383037 BP382906 BX505878 BP383146 CA307685 BM768857 BP383257 
    BP383098 AW950412 BM798497 BP382854 BP382863 T28210 BP383089 AA452530 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MEP1A expression in normal human tissues (normalized intensities)      MEP1A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGCACAT
    MEP1A Expression
    About this image


    MEP1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 3 entries
             small intestine   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Presumptive Podocytes Podocyte Layer
             visceral organ/metanephros/calyx   
     
     Colon (Gastrointestinal Tract)
             colonic mucosal (ibs)   
     
     Gut Tube (Gastrointestinal Tract)
             Midgut
     
     Lower Urinary Tract (Urinary System)
             visceral organ/metanephros/calyx   

    See MEP1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MEP1A

    SOURCE GeneReport for Unigene cluster: Hs.179704
        SABiosciences Custom PCR Arrays for MEP1A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEP1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MEP1A gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mep1a1 , 5 meprin 1 alpha1, 5 80.46(n)1
    76.64(a)1
      17 (19.73 cM)5
    172871  NM_008585.21  NP_032611.21 
     434743245 
    chicken
    (Gallus gallus)
    Aves MEP1A1 meprin A, alpha (PABA peptide hydrolase) 67.67(n)
    67.48(a)
      422060  XM_420065.3  XP_420065.2 
    lizard
    (Anolis carolinensis)
    Reptilia MEP1A6
    --
    Uncharacterized protein
    52(a)
    51(a)
    many → 1
    many → 1
    1(138435880-138457155)
    1(138465608-138485099)
    zebrafish
    (Danio rerio)
    Actinopterygii mep1a.21 meprin A, alpha.2 61.18(n)
    56.97(a)
      565535  NM_001128727.1  NP_001122199.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG66963 meprin A 37(a)
    (best of 3)
      17D1   --
    worm
    (Caenorhabditis elegans)
    Secernentea T04G9.23 zinc metalloprotease 38(a)
    (best of 5)
      X(811505-815543)   --


    ENSEMBL Gene Tree for MEP1A (if available)
    TreeFam Gene Tree for MEP1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MEP1A gene
    MEP1B2  ASTL2  
    1 SIMAP similar gene for MEP1A using alignment to 2 protein entries:     MEP1A_HUMAN (see all proteins):
    MEP1B

    MEP1A for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for MEP1A
    PGOHUM00000236074 PGOHUM00000236202 PGOHUM00000236516 PGOHUM00000236527


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1161 SNPs in MEP1A are shown (see all 1161)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs793220631,2
    C,F--46759095(+) CCCATC/TAGAAG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1853246301,2
    --46759104(+) AGCAGA/GCCCCC 1 -- us2k10--------
    rs1898086351,2
    --46759121(+) CATGCC/GTCCTA 1 -- us2k10--------
    rs762816601,2
    C,F--46759219(+) GCCCAG/ATAGTA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1120218541,2
    C,F--46759220(+) CCCAGT/CAGTAA 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    rs1151191501,2
    C,F--46759303(+) AGGCAA/CGAATA 1 -- us2k11Minor allele frequency- C:0.11WA 118
    rs573628021,2
    C--46759315(+) GTGGGT/CGTGTG 1 -- us2k14Minor allele frequency- C:0.08WA NA EA 360
    rs1142221671,2
    C,F--46759343(+) GCTGGC/TGCAGA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1502048401,2
    --46759431(+) ATCAAC/TAAACA 1 -- us2k10--------
    rs13289591,2
    C,F,A,H--46759450(-) ACCAAG/ACCTTT 1 -- us2k116Minor allele frequency- A:0.21NS EA NA WA 932

    HapMap Linkage Disequilibrium report for MEP1A (46761094 - 46807519 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for MEP1A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2535765CNV Deletion19546169
    esv1387664CNV Deletion17803354
    nsv823683CNV Gain20364138
    nsv428147CNV Gain18775914
    nsv7895CNV Gain18304495
    nsv823684CNV Gain20364138
    esv24845CNV Gain19812545
    nsv830654CNV Gain17160897
    nsv885868CNV Gain21882294
    dgv1948e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600388    OMIM disorders: --

    9 diseases for MEP1A:    About MalaCards
    vertebrobasilar insufficiency    dentin dysplasia    juvenile myoclonic epilepsy    carotid stenosis
    dentinogenesis imperfecta    arteriovenous malformation    migraine    inflammatory bowel disease
    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for MEP1A:
    Dentin dysplasia

    MEP1A for disorders           About GeneDecksing

    Genetic Association Database (GAD): MEP1A
    Human Genome Epidemiology (HuGE) Navigator: MEP1A (2 documents)

    Export disorders for MEP1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MEP1A gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with MEP1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease. (PubMed id 19262505)1, 4, 9 Banerjee S....Bond J.S. (2009)
    2. The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively. (PubMed id 7774936)1, 3, 9 Bond J.S....Jiang W. (1995)
    3. Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells. (PubMed id 8262185)1, 2, 9 Dumermuth E.... Sterchi E.E. (1993)
    4. Exclusion of the juvenile myoclonic epilepsy gene EFHC1 as the cause of migraine on chromosome 6, but association to two rare polymorphisms in MEP1A and RHAG. (PubMed id 16378686)1, 4 Norberg A....Holmberg M. (2006)
    5. Structure and expression of the human MEP1A gene encoding the alpha subunit of metalloendopeptidase meprin A. (PubMed id 10898933)1, 9 Jiang W. and Le B. (2000)
    6. Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p- aminobenzoic acid hydrolase (human meprin) alpha and beta subunits in Madin-Darby canine kidney cells. (PubMed id 9288916)1, 9 Eldering J.A....Sterchi E.E. (1997)
    7. Meprina transactivates the epidermal growth factor rec eptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proli feration and migration. (PubMed id 22923609)1 Minder P....Sterchi E.E. (2012)
    8. TNF-a-induced down-regulation of CDX2 suppresses MEP1A expression in colitis. (PubMed id 22326557)1 Coskun M....Troelsen J.T. (2012)
    9. Enhanced activity of meprin-a, a pro-migratory and pro -angiogenic protease, in colorectal cancer. (PubMed id 22096485)1 Lottaz D....Sterchi E.E. (2011)
    10. Processing of procollagen III by meprins: new players in extracellular matrix assembly? (PubMed id 20631730)1 Kronenberg D....Becker-Pauly C. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4224 HGNC: 7015 AceView: MEP1A Ensembl:ENSG00000112818 euGenes: HUgn4224
    ECgene: MEP1A Kegg: 4224 H-InvDB: MEP1A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MEP1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MEP1A gene:
    Search GeneIP for patents involving MEP1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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