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Aliases for MEP1A Gene

Aliases for MEP1A Gene

  • Meprin A, Alpha (PABA Peptide Hydrolase) 2 3
  • N-Benzoyl-L-Tyrosyl-P-Amino-Benzoic Acid Hydrolase Subunit Alpha 3 4
  • PABA Peptide Hydrolase 3 4
  • Endopeptidase-2 3 4
  • EC 3.4.24.18 4 63
  • PPH Alpha 3 4
  • BA268F1.1 (Meprin A Alpha (PABA Peptide Hydrolase)) 3
  • Meprin A Subunit Alpha 3
  • EC 3.4.24 63
  • PPHA 3

External Ids for MEP1A Gene

Previous GeneCards Identifiers for MEP1A Gene

  • GC06U990080
  • GC06P046757
  • GC06P046807
  • GC06P046869
  • GC06P046484

Summaries for MEP1A Gene

GeneCards Summary for MEP1A Gene

MEP1A (Meprin A, Alpha (PABA Peptide Hydrolase)) is a Protein Coding gene. Diseases associated with MEP1A include dentin dysplasia. Among its related pathways are Protein digestion and absorption. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ASTL.

Gene Wiki entry for MEP1A Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEP1A Gene

Genomics for MEP1A Gene

Regulatory Elements for MEP1A Gene

Genomic Location for MEP1A Gene

Start:
46,793,357 bp from pter
End:
46,839,782 bp from pter
Size:
46,426 bases
Orientation:
Plus strand

Genomic View for MEP1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEP1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEP1A Gene

Proteins for MEP1A Gene

  • Protein details for MEP1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16819-MEP1A_HUMAN
    Recommended name:
    Meprin A subunit alpha
    Protein Accession:
    Q16819
    Secondary Accessions:
    • A2RRM4
    • B0AZP9
    • B2RCS2
    • Q8TDC9
    • Q9H1R1

    Protein attributes for MEP1A Gene

    Size:
    746 amino acids
    Molecular mass:
    84419 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Homotetramer consisting of disulfide-linked alpha subunits, homooligomer consisting of disulfide-linked alpha subunit homodimers, or heterotetramer of two alpha and two beta subunits formed by non-covalent association of two disulfide-linked heterodimers (By similarity). Interacts with MBL2 through its carbohydrate moiety. This interaction may inhibit its catalytic activity (By similarity).

neXtProt entry for MEP1A Gene

Proteomics data for MEP1A Gene at MOPED

Selected DME Specific Peptides for MEP1A Gene

Post-translational modifications for MEP1A Gene

  • N-glycosylated; contains GlcNAc, galactose, mannose and a small amount of fucose.
  • Glycosylation at Asn140, Asn222, Asn258, Asn414, Asn440, Asn447, and Asn539
  • Modification sites at PhosphoSitePlus

Other Protein References for MEP1A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for MEP1A Gene

Suggested Antigen Peptide Sequences for MEP1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16819

UniProtKB/Swiss-Prot:

MEP1A_HUMAN :
  • Q16819
Domain:
  • Contains 1 EGF-like domain.
  • Contains 1 MAM domain.
  • Contains 1 MATH domain.
Family:
  • Belongs to the peptidase M12A family.
genes like me logo Genes that share domains with MEP1A: view

No data available for Gene Families for MEP1A Gene

Function for MEP1A Gene

Molecular function for MEP1A Gene

GENATLAS Biochemistry: zinc metalloendopeptidase 1,meprin,alpha subunit,astacin family of metalloendopeptidases
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=110 uM for GRP {ECO:0000269 PubMed:17976009}; KM=18.0 uM for PTH 12-34 {ECO:0000269 PubMed:17976009}; KM=33.9 uM for secretin {ECO:0000269 PubMed:17976009}; KM=41.3 uM for substance P {ECO:0000269 PubMed:17976009}; KM=56.5 uM for LHRH {ECO:0000269 PubMed:17976009}; KM=73.2 uM for orcokinin {ECO:0000269 PubMed:17976009}; KM=292 uM for alpha-MSH {ECO:0000269 PubMed:17976009}; KM=125 uM for bradykinin {ECO:0000269 PubMed:17976009}; KM=200 uM for gastrin {ECO:0000269 PubMed:17976009};
UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by several hydroxamate compounds, the most potent inhibitor is actinonin.

Enzyme Numbers (IUBMB) for MEP1A Gene

Gene Ontology (GO) - Molecular Function for MEP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005515 protein binding IPI 23123160
GO:0008237 metallopeptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MEP1A: view
genes like me logo Genes that share phenotypes with MEP1A: view

Animal Models for MEP1A Gene

MGI Knock Outs for MEP1A:

Animal Model Products

miRNA for MEP1A Gene

miRTarBase miRNAs that target MEP1A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEP1A

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for MEP1A Gene

Localization for MEP1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEP1A Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEP1A Gene COMPARTMENTS Subcellular localization image for MEP1A gene
Compartment Confidence
extracellular 4
plasma membrane 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MEP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 8262185
GO:0005887 integral component of plasma membrane TAS 8262185
GO:0016020 membrane --
GO:0017090 meprin A complex IEA --
GO:0070062 extracellular exosome IDA 11487543
genes like me logo Genes that share ontologies with MEP1A: view

Pathways for MEP1A Gene

genes like me logo Genes that share pathways with MEP1A: view

Pathways by source for MEP1A Gene

1 KEGG pathway for MEP1A Gene

Gene Ontology (GO) - Biological Process for MEP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007586 digestion TAS 9288916
genes like me logo Genes that share ontologies with MEP1A: view

Transcripts for MEP1A Gene

Unigene Clusters for MEP1A Gene

Meprin A, alpha (PABA peptide hydrolase):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEP1A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MEP1A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEP1A Gene

No ASD Table

Relevant External Links for MEP1A Gene

GeneLoc Exon Structure for
MEP1A
ECgene alternative splicing isoforms for
MEP1A

Expression for MEP1A Gene

mRNA expression in normal human tissues for MEP1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEP1A Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (34.9) and Colon - Transverse (16.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MEP1A Gene

SOURCE GeneReport for Unigene cluster for MEP1A Gene Hs.179704

genes like me logo Genes that share expressions with MEP1A: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MEP1A Gene

Orthologs for MEP1A Gene

This gene was present in the common ancestor of animals.

Orthologs for MEP1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEP1A 35
  • 99.46 (n)
  • 99.33 (a)
MEP1A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MEP1A 35
  • 85.39 (n)
  • 82.55 (a)
MEP1A 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEP1A 35
  • 86.76 (n)
  • 82.95 (a)
MEP1A 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mep1a 35
  • 79.88 (n)
  • 75.54 (a)
Mep1a 16
Mep1a 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MEP1A 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEP1A 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mep1a 35
  • 79.84 (n)
  • 76.21 (a)
chicken
(Gallus gallus)
Aves MEP1A 35
  • 67.57 (n)
  • 67.28 (a)
MEP1A 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEP1A 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mep1a 35
  • 64.5 (n)
  • 62.28 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2334 35
zebrafish
(Danio rerio)
Actinopterygii mep1a.1 36
  • 57 (a)
OneToOne
mep1a.2 35
  • 61.47 (n)
  • 57.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15253 36
  • 33 (a)
ManyToMany
CG6696 37
  • 37 (a)
BG:BACR44L22.1 37
  • 33 (a)
BG:BACR44L22.6 37
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea T04G9.2 37
  • 38 (a)
K04E7.3 37
  • 32 (a)
C07D10.4 37
  • 36 (a)
4R79.1 37
  • 38 (a)
C05D11.6 37
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
ManyToMany
Species with no ortholog for MEP1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEP1A Gene

ENSEMBL:
Gene Tree for MEP1A (if available)
TreeFam:
Gene Tree for MEP1A (if available)

Paralogs for MEP1A Gene

Paralogs for MEP1A Gene

Selected SIMAP similar genes for MEP1A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MEP1A Gene

genes like me logo Genes that share paralogs with MEP1A: view

Variants for MEP1A Gene

Sequence variations from dbSNP and Humsavar for MEP1A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs872018 -- 46,798,730(+) CCCTG(C/G)GATGG intron-variant
rs872019 -- 46,798,731(+) CCTGG(C/G)ATGGG intron-variant
rs1059276 -- 46,839,303(-) TAACA(G/T)AATTA utr-variant-3-prime
rs1226585 -- 46,802,196(-) atagg(A/G)ctcaa intron-variant
rs1328959 -- 46,791,713(-) ACCAA(A/G)CCTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MEP1A Gene

Variant ID Type Subtype PubMed ID
nsv885868 CNV Gain 21882294
nsv428147 CNV Gain 18775914
dgv1948e1 CNV Complex 17122850
nsv830654 CNV Gain 17160897
esv2535765 CNV Deletion 19546169
esv1387664 CNV Deletion 17803354
esv24845 CNV Gain 19812545
nsv7895 CNV Gain 18304495
nsv823683 CNV Gain 20364138
nsv823684 CNV Gain 20364138

Relevant External Links for MEP1A Gene

HapMap Linkage Disequilibrium report
MEP1A
Human Gene Mutation Database (HGMD)
MEP1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEP1A Gene

Disorders for MEP1A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MEP1A Gene including...

Search for MEP1A Gene in MalaCards »

(1) University of Copenhagen DISEASES for MEP1A Gene

Relevant External Links for MEP1A

Genetic Association Database (GAD)
MEP1A
Human Genome Epidemiology (HuGE) Navigator
MEP1A
genes like me logo Genes that share disorders with MEP1A: view

No data available for UniProtKB/Swiss-Prot for MEP1A Gene

Publications for MEP1A Gene

  1. MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease. (PMID: 19262505) Banerjee S. … Bond J.S. (Mucosal Immunol 2009) 3 23 48
  2. The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively. (PMID: 7774936) Bond J.S. … Jiang W. (Genomics 1995) 2 3 23
  3. Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells. (PMID: 8262185) Dumermuth E. … Sterchi E.E. (FEBS Lett. 1993) 3 4 23
  4. Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p- aminobenzoic acid hydrolase (human meprin) alpha and beta subunits in Madin-Darby canine kidney cells. (PMID: 9288916) Eldering J.A. … Sterchi E.E. (Eur. J. Biochem. 1997) 3 23
  5. Structure and expression of the human MEP1A gene encoding the alpha subunit of metalloendopeptidase meprin A. (PMID: 10898933) Jiang W. … Le B. (Arch. Biochem. Biophys. 2000) 3 23

Products for MEP1A Gene

Sources for MEP1A Gene

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