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MEOX2 Gene

protein-coding   GIFtS: 57
GCID: GC07M015617

Mesenchyme Homeobox 2

(Previous names: mesenchyme homeo box 2 (growth arrest-specific homeo box),...)
(Previous symbol: GAX)
  See MEOX2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mesenchyme Homeobox 21 2 3     Mesenchyme Homeo Box 2 (Growth Arrest-Specific Homeo Box)1
GAX1 2 3     Mesenchyme Homeobox 2 (Growth Arrest-Specific Homeo Box)1
Growth Arrest-Specific Homeobox1 2 3     Homeobox Protein MOX-22
MOX22 3     

External Ids:    HGNC: 70141   Entrez Gene: 42232   Ensembl: ENSG000001065117   OMIM: 6005355   UniProtKB: P502223   

Export aliases for MEOX2 gene to outside databases

Previous GC identifers: GC07M015295 GC07M015395 GC07M015424


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MEOX2 Gene:
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes.
The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related
mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular
dysfunction observed in Alzheimer's disease. (provided by RefSeq, Jul 2008)

GeneCards Summary for MEOX2 Gene:
MEOX2 (mesenchyme homeobox 2) is a protein-coding gene. Diseases associated with MEOX2 include low compliance bladder, and female stress incontinence. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSX1.

UniProtKB/Swiss-Prot: MEOX2_HUMAN, P50222
Function: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and
sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the
cell cycle (By similarity)

Gene Wiki entry for MEOX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the MEOX2 gene promoter:
         TBP   GATA-3   IRF-1   NF-kappaB   NF-kappaB1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMEOX2 promoter sequence
   Search Chromatin IP Primers for MEOX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEOX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1-p21.3   Ensembl cytogenetic band:  7p21.2   HGNC cytogenetic band: 7p22.1-p21.3

MEOX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEOX2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M015617:  view genomic region     (about GC identifiers)

Start:
15,650,837 bp from pter      End:
15,726,437 bp from pter
Size:
75,601 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 15,703,946-15,779,448     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MEOX2_HUMAN, P50222 (See protein sequence)
Recommended Name: Homeobox protein MOX-2  
Size: 304 amino acids; 33594 Da
Subunit: Interacts with RNF10
Secondary accessions: O75263 Q9UPL6

Explore the universe of human proteins at neXtProt for MEOX2: NX_P50222

Explore proteomics data for MEOX2 at MOPED


See MEOX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_005915.2  
ENSEMBL proteins: 
 ENSP00000262041  

MEOX2 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for MEOX2

 
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antibodies-online proteins for MEOX2 (7 products) 

 
antibodies-online peptides for MEOX2

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antibodies-online antibodies for MEOX2 (71 products) 

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antibodies-online kits for MEOX2 (6 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
HOXL: Homeoboxes / ANTP class : HOXL subclass

4 InterPro protein domains:
 IPR020479 Homeobox_metazoa
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry P50222

ProtoNet protein and cluster: P50222

1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

UniProtKB/Swiss-Prot: MEOX2_HUMAN, P50222
Domain: The polyhistidine repeat may act as a targeting signal to nuclear speckles (PubMed:19266028)
Similarity: Contains 1 homeobox DNA-binding domain


Find genes that share domains with MEOX2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: MEOX2_HUMAN, P50222
Function: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and
sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the
cell cycle (By similarity)

     Genatlas biochemistry entry for MEOX2:
mesenchyme homeo box, murine Mox2,homolog

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0005515protein binding IPI16335786
GO:0043565sequence-specific DNA binding IDA9073066
     
Find genes that share ontologies with MEOX2           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for MEOX2:
 Increased homologous recombina 

     Selected MGI mutant phenotypes (inferred from 4 alleles(MGI details for Meox2) (see all 25):
 adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
 digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system 
 homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

Find genes that share phenotypes with MEOX2           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Meox2tm1Vpa for MEOX2

   genOway: Develop your customized and physiologically relevant rodent model for MEOX2

miRNA
Products:
    
miRTarBase miRNAs that target MEOX2:
hsa-mir-221-3p (MIRT024208), hsa-mir-335-5p (MIRT018453), hsa-mir-301a-3p (MIRT003611), hsa-mir-130a-3p (MIRT004358), hsa-mir-320a (MIRT044481)

Block miRNA regulation of human, mouse, rat MEOX2 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate MEOX2 (see all 33):
hsa-miR-2052 hsa-miR-19b-2* hsa-miR-15a hsa-miR-301a hsa-miR-424 hsa-miR-15b hsa-miR-130b hsa-miR-374b*
SwitchGear 3'UTR luciferase reporter plasmidMEOX2 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat MEOX2

Gene Editing
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GenScript: all cDNA clones in your preferred vector: MEOX2 (NM_005924)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEOX2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEOX2

Cell Line
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GenScript Custom overexpressing Cell Line Services for MEOX2
Browse ESI BIO Cell Lines and PureStem Progenitors for MEOX2 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEOX2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
MEOX2_HUMAN, P50222: Nucleus. Nucleus speckle
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
extracellular2

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IDA16335786
GO:0016607nuclear speck IEA--

Find genes that share ontologies with MEOX2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MEOX2
Interactions:

    GeneGlobe Interaction Network for MEOX2

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

Selected Interacting proteins for MEOX2 (P502222, 3 ENSP000002620414) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
InteractantInteraction Details
GeneCardExternal ID(s)
SAMM50Q9Y5122, 3, ENSP000003454454MINT-67293 I2D: score=5 STRING: ENSP00000345445
RND2P521982, 3MINT-67514 I2D: score=4 
PAX3P237602, 3, ENSP000003759214MINT-15278 MINT-15279 I2D: score=5 STRING: ENSP00000375921
HSPA2P546522, 3, ENSP000002472074MINT-2860884 I2D: score=3 STRING: ENSP00000247207
VIPP012822, 3, ENSP000003562134MINT-68122 I2D: score=5 STRING: ENSP00000356213
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Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001525angiogenesis IEA--
GO:0001757somite specification IEA--
GO:0006355regulation of transcription, DNA-templated ----
GO:0007275multicellular organismal development TAS7713505
GO:0007519skeletal muscle tissue development IEA--

Find genes that share ontologies with MEOX2           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MEOX2

4 Novoseek inferred chemical compound relationships for MEOX2 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
matrigel 43.4 2 12842453 (1), 15735029 (1)
thymidine 32.6 3 9552512 (1), 12842453 (1), 8796105 (1)
histidine 28.5 2 7607679 (1)
nitric oxide 0 2 9552512 (1), 8796105 (1)



Find genes that share compounds with MEOX2           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MEOX2 gene: 
NM_005924.4  

Unigene Cluster for MEOX2:

Mesenchyme homeobox 2
Hs.170355  [show with all ESTs]
Unigene Representative Sequence: NM_005924
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000262041(uc003stc.3)
miRNA
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Block miRNA regulation of human, mouse, rat MEOX2 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate MEOX2 (see all 33):
hsa-miR-2052 hsa-miR-19b-2* hsa-miR-15a hsa-miR-301a hsa-miR-424 hsa-miR-15b hsa-miR-130b hsa-miR-374b*
SwitchGear 3'UTR luciferase reporter plasmidMEOX2 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for MEOX2
Predesigned siRNA for gene silencing in human, mouse, rat MEOX2
Clone
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OriGene clones in human, mouse for MEOX2 (see all 7)
OriGene ORF clones in mouse, rat for MEOX2
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GenScript: all cDNA clones in your preferred vector: MEOX2 (NM_005924)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEOX2
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Primer
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OriGene qPCR primer pairs and template standards for MEOX2
OriGene qSTAR qPCR primer pairs in human, mouse for MEOX2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MEOX2
  QuantiTect SYBR Green Assays in human, mouse, rat MEOX2
  QuantiFast Probe-based Assays in human, mouse, rat MEOX2

Additional mRNA sequence: 

AK309472.1 AK313386.1 BC017021.1 CR536553.1 L36328.1 X82629.1 

5 DOTS entries:

DT.312727  DT.100752325  DT.100752324  DT.102826664  DT.95267883 

Selected AceView cDNA sequences (see all 72):

CD518172 AI467833 CA405528 F02393 AW628626 AI523234 Z39263 CD621383 
AA921812 CD621375 CD104938 CD621385 AA496020 AI743406 AU137382 CD621374 
CD621378 NM_005924 AL544089 BQ881750 BX090450 BC017021 AW662773 CR536553 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MEOX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CAGAACAACT
MEOX2 Expression
About this image


MEOX2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 8) fully expand
 
 Adipose (Muscoskeletal System)    fully expand to see all 10 entries
         Sacral Brown Adipocyte Cells Sacral Brown Adipose Depot
         Body Subcutaneous White Adipose
 
 Kidney (Urinary System)    fully expand to see all 2 entries
         Metanephric Mesenchyme Cells Metanephric Mesenchyme
         Renal Vesicle
 
 Limb (Muscoskeletal System)    fully expand to see all 2 entries
         Limb Muscle Progenitor Cells Forelimb Myotome
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Limb Muscle Progenitor Cells Forelimb Myotome
 
 Bone (Muscoskeletal System)
         Zeugopod Epiphyseal End
MEOX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MEOX2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.170355

UniProtKB/Swiss-Prot: MEOX2_HUMAN, P50222
Tissue specificity: Embryo and placenta

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEOX2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for MEOX2 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Meox21 , 5 mesenchyme homeobox 21, 5 89.44(n)1
98.02(a)1
  12 (16.84 cM)5
172861  NM_008584.31  NP_032610.11 
 371085405 
chicken
(Gallus gallus)
Aves MEOX21 mesenchyme homeobox 2 84.11(n)
93.05(a)
  374137  NM_001005427.1  NP_001005427.1 
lizard
(Anolis carolinensis)
Reptilia MEOX26
mesenchyme homeobox 2
87(a)
1 ↔ 1
6(27051956-27123735)
African clawed frog
(Xenopus laevis)
Amphibia meox2-prov2 mesenchyme homeobox 2 76.37(n)    BC044705.1 
zebrafish
(Danio rerio)
Actinopterygii LOC5568981 homeobox protein MOX-2-like 66.21(n)
70.31(a)
  556898  XM_679832.2  XP_684924.1 
fruit fly
(Drosophila melanogaster)
Insecta btn6
buttonless
41(a)
1 → many
3R(18411871-18412347)


ENSEMBL Gene Tree for MEOX2 (if available)
TreeFam Gene Tree for MEOX2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MEOX2 gene
GSX12  HOXA32  MEOX12  EVX22  HOXA12  HOXB12  HOXB32  HOXD12  
HOXA22  GSX22  EVX12  HOXB22  PDX12  HOXD32  
7 SIMAP similar genes for MEOX2 using alignment to 3 protein entries:     MEOX2_HUMAN (see all proteins):
HOXC13    HOXA4    HOX B6    HOXB1    POU6F1    MEOX1
HHEX

Find genes that share paralogs with MEOX2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Polymorphic Variants from UniProtKB/Swiss-Prot
MEOX2_HUMAN, P50222: The poly-His region of MEOX2 is polymorphic and the number of His varies in the population


Selected SNPs for MEOX2 (see all 1745)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1413787881,2
--15623620(+) GCATCA/CTTTAC 1 -- ds50010--------
rs69762021,2
C,F,A,H--15623650(+) AGAACC/TGAGGA 1 -- ds500112Minor allele frequency- T:0.43NS EA WA NA CSA 786
rs69562201,2
C,F,A,H--15623669(+) AGCTTG/CTTTAG 1 -- ds500112Minor allele frequency- C:0.27NA WA CSA EA 510
rs1469732821,2
--15623687(+) TTCACA/GTCAGA 1 -- ds50010--------
rs1868226441,2
--15623696(+) GAGACA/TCTGCA 1 -- ds50010--------
rs1928678291,2
--15623714(+) ACTATA/GAAACC 1 -- ds50010--------
rs1143567481,2
F--15623727(+) TGTTGG/CATTAA 1 -- ds50011Minor allele frequency- C:0.05WA 118
rs1409784831,2
C--15623770(+) ATGAC-/TATTTTA 1 -- ds50010--------
rs766730131,2
C,F--15623825(+) TACTTT/ATATCT 1 -- ds50011Minor allele frequency- A:0.09WA 118
rs1849069601,2
--15623963(+) AAAAAA/TTTCAG 1 -- ds50010--------

HapMap Linkage Disequilibrium report for MEOX2 (15650837 - 15726437 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for MEOX2:    About this table    
Variant IDTypeSubtypePubMed ID
esv273709CNV Insertion20981092
nsv464392CNV Loss19166990
nsv824016CNV Loss20364138
nsv887735CNV Loss21882294
dgv7213n71CNV Loss21882294
esv27709CNV Loss19812545
nsv523199CNV Gain19592680
nsv830911CNV Gain17160897

Human Gene Mutation Database (HGMD): MEOX2
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MEOX2
DNA2.0 Custom Variant and Variant Library Synthesis for MEOX2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 600535    OMIM disorders: --

4 diseases for MEOX2:    
About MalaCards
low compliance bladder    female stress incontinence    urethral intrinsic sphincter deficiency    neurogenic bladder

5 diseases from the University of Copenhagen DISEASES database for MEOX2:
Female stress incontinence     Urethral intrinsic sphincter deficiency     Vesicoureteral reflux     Neurogenic bladder
Low compliance bladder

Find genes that share disorders with MEOX2           About GenesLikeMe

2 Novoseek inferred disease relationships for MEOX2 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
hyperplasia 17.6 2 9552512 (1), 8796105 (1)
alzheimers disease 7.49 2 16116430 (2)

Genetic Association Database (GAD): MEOX2
Human Genome Epidemiology (HuGE) Navigator: MEOX2 (2 documents)

Export disorders for MEOX2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MEOX2 gene, integrated from 10 sources (see all 42):
(articles sorted by number of sources associating them with MEOX2)
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  1. Molecular cloning and localization of the human GAX gene to 7p21. (PubMed id 7713505)1, 2, 3 Lepage D.F. and Walsh K. (Genomics 1994)
  2. Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3. (PubMed id 7607679)1, 2, 9 Grigoriou M.... Karagogeos D. (Genomics 1995)
  3. Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10. (PubMed id 16335786)1, 2, 9 Lin J.... Wigle J.T. (Mol. Cell. Biochem. 2005)
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
  7. Inhibition of endothelial cell activation by the homeobox gene Gax. (PubMed id 12842453)1, 9 Gorski D.H. and Leal A.J. (J. Surg. Res. 2003)
  8. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. (PubMed id 16116430)1, 9 Wu Z....Zlokovic B.V. (Nat. Med. 2005)
  9. A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a. (PubMed id 19340300)1, 9 Irelan J.T....Chanda S.K. (PLoS ONE 2009)
  10. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PubMed id 23720494)1 Evans D.M....Whitfield J.B. (Hum. Mol. Genet. 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4223 HGNC: 7014 AceView: MEOX2 Ensembl:ENSG00000106511 euGenes: HUgn4223
ECgene: MEOX2 H-InvDB: MEOX2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MEOX2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MEOX2 gene:
Search GeneIP for patents involving MEOX2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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