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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MEOX2 Gene

protein-coding   GIFtS: 57
GCID: GC07M015617

mesenchyme homeobox 2

(Previous names: mesenchyme homeo box 2 (growth arrest-specific homeo box),...)
(Previous symbol: GAX)
 Explore 13 diseases affiliated with
MEOX2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MEOX2    

Aliases
for MEOX2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mesenchyme Homeobox 21 2 3     Mesenchyme Homeo Box 2 (Growth Arrest-Specific Homeo Box)1
GAX1 2 3     Mesenchyme Homeobox 2 (Growth Arrest-Specific Homeo Box)1
MOX21 2 3     Homeobox Protein MOX-22
Growth Arrest-Specific Homeobox2 3     

External Ids:    HGNC: 70141   Entrez Gene: 42232   Ensembl: ENSG000001065117   OMIM: 6005355   UniProtKB: P502223   

Export aliases for MEOX2 gene to outside databases

Previous GC identifers: GC07M015295 GC07M015395 GC07M015424


Summaries
for MEOX2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MEOX2:
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The
encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse
protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction
observed in Alzheimer's disease. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MEOX2_HUMAN, P50222
Function: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and
sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell
cycle (By similarity)

Gene Wiki entry for MEOX2


Genomic Views
for MEOX2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MEOX2 gene promoter:
         TBP   GATA-3   IRF-1   NF-kappaB   NF-kappaB1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MEOX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MEOX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEOX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1-p21.3   Ensembl cytogenetic band:  7p21.2   HGNC cytogenetic band: 7p22.1-p21.3

MEOX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEOX2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M015617:  view genomic region     (about GC identifiers)

Start:
 15,650,837 bp from pter      End:
 15,726,437 bp from pter
Size:
 75,601 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 15,703,946-15,779,448     

Proteins
for MEOX2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MEOX2_HUMAN, P50222 (See protein sequence)
Recommended Name: Homeobox protein MOX-2  
Size: 304 amino acids; 33594 Da
Subunit: Interacts with RNF10
Subcellular location: Nucleus. Nucleus speckle
Secondary accessions: O75263 Q9UPL6

Explore the universe of human proteins at neXtProt for MEOX2: NX_P50222

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P50222

    • MEOX2 Protein expression data from MOPED and PaxDb:    About this image 
    MEOX2 Protein Expression
    REFSEQ proteins: NP_005915.2  
    ENSEMBL proteins: 
     ENSP00000262041  

    Human Recombinant Protein Products for MEOX2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: MEOX2
    OriGene Custom Protein Services for MEOX2 
    GenScript Custom Purified and Recombinant Proteins Services for MEOX2
    Novus Biologicals MEOX2 Protein
    Novus Biologicals MEOX2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MEOX2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA16335786
    GO:0016607nuclear speck IEA--

    MEOX2 for ontologies           About GeneDecksing



    MEOX2 Antibody Products: 
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    Novus Biologicals MEOX2 Antibodies
    Abcam antibodies for MEOX2 
    Uscn Antibodies for MEOX2
    Search ThermoFisher Antibodies for MEOX2

    Assay Products for MEOX2: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for MEOX2

    Protein Domains /
    Families
    for MEOX2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MEOX2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P50222

    ProtoNet protein and cluster: P50222

    1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: MEOX2_HUMAN, P50222
    Domain: The polyhistidine repeat may act as a targeting signal to nuclear speckles (PubMed:19266028)
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for MEOX2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MEOX2_HUMAN, P50222
    Function: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and
    sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell
    cycle (By similarity)

         Genatlas biochemistry entry for MEOX2:
    mesenchyme homeo box, murine Mox2,homolog

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI16335786
    GO:0043565sequence-specific DNA binding IDA9073066
         
    MEOX2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MEOX2:
     Increased homologous recombina 

         15/25 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Meox2) (see all 25):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    MEOX2 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Meox2tm1Vpa for MEOX2
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MEOX2 

    miRNA
    Products:            		miRTarBase miRNAs that target MEOX2:
    hsa-mir-301a (MIRT003611), hsa-mir-130a (MIRT004358)

    OriGene 3'-UTR Clone: MEOX2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEOX2
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate MEOX2 (see all 33):
    hsa-miR-2052 hsa-miR-19b-2* hsa-miR-15a hsa-miR-301a hsa-miR-424 hsa-miR-15b hsa-miR-130b hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmid: MEOX2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEOX2 (see all 7)
    OriGene shRNA RFP: MEOX2
    OriGene siRNA: MEOX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEOX2
    Sirion Biotech Custom design and validation of potent shRNA sequences against MEOX2 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MEOX2
    Sirion Biotech Customized adenovirus for overexpression of MEOX2 
    Sirion Biotech Customized adenovirus for potent knockdown of MEOX2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEOX2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEOX2 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MEOX2 (NM_005924)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEOX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEOX2 

    Cell Line
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    Search LifeMap BioReagents cell lines for MEOX2
    Sirion Biotech Customized stable knockdown cell line services for MEOX2 
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    Sirion Biotech Customized inducible overexpressing cell line services for MEOX2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEOX2


    Pathways & Interactions
    for MEOX2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MEOX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/20 Interacting proteins for MEOX2 (P502222, 3 ENSP000002620414) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SAMM50Q9Y5122, 3, ENSP000003454454MINT-67293 I2D: score=5 STRING: ENSP00000345445
    RND2P521982, 3MINT-67514 I2D: score=4 
    PAX3P237602, 3, ENSP000003759214MINT-15278 MINT-15279 I2D: score=5 STRING: ENSP00000375921
    HSPA2P546522, 3, ENSP000002472074MINT-2860884 I2D: score=3 STRING: ENSP00000247207
    VIPP012822, 3, ENSP000003562134MINT-68122 I2D: score=5 STRING: ENSP00000356213
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001757somite specification IEA--
    GO:0007275multicellular organismal development TAS7713505
    GO:0007519skeletal muscle tissue development IEA--
    GO:0008015blood circulation TAS7713505

    MEOX2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MEOX2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MEOX2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MEOX2
    4 Novoseek chemical compound relationships for MEOX2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 43.4 2 12842453 (1), 15735029 (1)
    thymidine 32.6 3 9552512 (1), 12842453 (1), 8796105 (1)
    histidine 28.5 2 7607679 (1)
    nitric oxide 0 2 9552512 (1), 8796105 (1)

    Search CenterWatch for drugs/clinical trials and news about MEOX2 

    Transcripts
    for MEOX2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MEOX2 gene: 
    NM_005924.4  

    Unigene Cluster for MEOX2:

    Mesenchyme homeobox 2
    Hs.170355  [show with all ESTs]
    Unigene Representative Sequence: NM_005924
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000262041(uc003stc.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MEOX2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEOX2
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate MEOX2 (see all 33):
    hsa-miR-2052 hsa-miR-19b-2* hsa-miR-15a hsa-miR-301a hsa-miR-424 hsa-miR-15b hsa-miR-130b hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmid: MEOX2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEOX2 (see all 7)
    OriGene shRNA RFP: MEOX2
    OriGene siRNA: MEOX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEOX2
    Sirion Biotech Custom design and validation of potent shRNA sequences against MEOX2 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEOX2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEOX2 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MEOX2 (NM_005924)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEOX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEOX2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEOX2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MEOX2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEOX2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEOX2

    Additional cDNA sequence: 

    AK309472.1 AK313386.1 BC017021.1 CR536553.1 L36328.1 X82629.1 

    5 DOTS entries:

    DT.312727  DT.100752325  DT.100752324  DT.102826664  DT.95267883 

    24/72 AceView cDNA sequences (see all 72):

    CD518172 AW628626 CA405528 Z39263 AI467833 AI523234 AA921812 F02393 
    CD621383 AW662773 BQ007850 CD621376 AL544089 BU682093 BF111571 AA489656 
    CD621385 AA496020 BQ025060 CD621379 AU137382 AA599019 BI524836 BM973746 

    GeneLoc Exon Structure


    Expression
    for MEOX2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MEOX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGAACAACT
    MEOX2 Expression
    About this image

    MEOX2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    10/19 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 19) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeCervical Brown Adipose DepotCervical Brown Adipocyte CellsAdipose
    AdiposeCervical Brown Adipose DepotCervical Committed Brown PreadipocytesAdipose
    AdiposeLumbar Brown Adipose DepotLumbar Brown Adipocyte CellsAdipose
    AdiposeLumbar Brown Adipose DepotLumbar Committed Brown PreadipocytesAdipose
    AdiposeSacral Brown Adipose DepotSacral Brown Adipocyte CellsAdipose
    AdiposeSacral Brown Adipose DepotSacral Committed Brown PreadipocytesAdipose
    AdiposeThoracic Brown Adipose DepotThoracic Brown Adipocyte CellsAdipose
    AdiposeThoracic Brown Adipose DepotThoracic Committed Brown PreadipocytesAdipose
    LimbForelimb Dorsal MusclesMyoblastsSkeletal Muscle
    LimbForelimb MyotomeLimb Muscle Progenitor CellsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MEOX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MEOX2

    SOURCE GeneReport for Unigene cluster: Hs.170355

    UniProtKB/Swiss-Prot: MEOX2_HUMAN, P50222
    Tissue specificity: Embryo and placenta

        SABiosciences Custom PCR Arrays for MEOX2
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEOX2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEOX2

    Orthologs
    for MEOX2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MEOX2 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MEOX21 mesenchyme homeobox 2 84.44(n)
    94.04(a)    		   374137  NM_001005427.1  NP_001005427.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MEOX26
    		 --
    		 87(a)
    		 1 ↔ 1
    		 6(27053049-27123735)
    African clawed frog
    (Xenopus laevis)    		 Amphibia meox2-prov2 mesenchyme homeobox 2 76.37(n)    BC044705.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5568981 homeobox protein MOX-2-like 66.55(n)
    72.16(a)    		   556898  XM_679832.1  XP_684924.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta btn6
    		 buttonless
    		 35(a)
    		 1 → many
    		 3R(18411871-18412347)
    worm
    (Caenorhabditis elegans)    		 Secernentea ceh-126
    		 Homeobox protein ceh-12
    		 20(a)
    		 possible ortholog
    		 I(5840292-5841891)


    ENSEMBL Gene Tree for MEOX2 (if available)
    TreeFam Gene Tree for MEOX2 (if available) 

    Paralogs
    for MEOX2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MEOX2 gene
    NKX1-22  MEOX12  EVX22  GBX12  NKX1-12  GBX22  MNX12  EVX12  
    7 SIMAP similar genes for MEOX2 using alignment to 3 protein entries:     MEOX2_HUMAN (see all proteins):
    HOXC13    HOXA4    HOX B6    HOXB1    MEOX1    POU6F1
    HHEX

    MEOX2 for paralogs           About GeneDecksing



    Genomic Variants
    for MEOX2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: MEOX2_HUMAN, P50222
    Polymorphism: The poly-His region of MEOX2 is polymorphic and the number of His varies in the population


    10/1457 NCBI SNPs in MEOX2 are shown (see all 1457)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1413787881,2
    		--15650355(+) GCATCA/CTTTAC 1 -- ds50010--------
    rs69762021,2
    		C,F,A,H--15650385(+) AGAACC/TGAGGA 1 -- ds500112Minor allele frequency- T:0.43NS EA WA NA CSA 786
    rs69562201,2
    		C,F,A,H--15650404(+) AGCTTG/CTTTAG 1 -- ds500112Minor allele frequency- C:0.27NA WA CSA EA 510
    rs1469732821,2
    		--15650422(+) TTCACA/GTCAGA 1 -- ds50010--------
    rs1868226441,2
    		--15650431(+) GAGACA/TCTGCA 1 -- ds50010--------
    rs1928678291,2
    		--15650449(+) ACTATA/GAAACC 1 -- ds50010--------
    rs1143567481,2
    		F--15650462(+) TGTTGG/CATTAA 1 -- ds50011Minor allele frequency- C:0.05WA 118
    rs1409784831,2
    		C--15650505(+) ATGAC-/TATTTTA 1 -- ds50010--------
    rs766730131,2
    		F--15650560(+) TACTTT/ATATCT 1 -- ds50011Minor allele frequency- A:0.09WA 118
    rs1849069601,2
    		--15650698(+) AAAAAA/TTTCAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MEOX2 (15650837 - 15726437 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MEOX2
         1 Indel: 69810
    Human Gene Mutation Database (HGMD): MEOX2

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    Disorders / Diseases
    for MEOX2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MEOX2 for disorders           About GeneDecksing

    OMIM gene information: 600535    OMIM disorders: --

    13 diseases for MEOX2:    About MalaCards
    urethral intrinsic sphincter deficiency    female stress incontinence    alzheimer's disease    human t-cell leukemia virus type 1
    vesicoureteral reflux    neurogenic bladder    urethritis    portal hypertension
    wilms tumor    t-cell leukemia    hypertension    leukemia
    ataxia

    5 diseases from the University of Copenhagen DISEASES database for MEOX2:
    Female stress incontinence     Urethral intrinsic sphincter deficiency     Vesicoureteral reflux     Low compliance bladder
    Neurogenic bladder

    2 Novoseek disease relationships for MEOX2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperplasia 17.6 2 9552512 (1), 8796105 (1)
    alzheimers disease 7.49 2 16116430 (2)

    Human Genome Epidemiology (HuGE) Navigator: MEOX2 (2 documents)

    Export disorders for MEOX2 gene to outside databases

    Publications
    for MEOX2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MEOX2 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with MEOX2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and localization of the human GAX gene to 7p21. (PubMed id 7713505)1, 2, 3 Lepage D.F. and Walsh K. (1994)
    2. Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3. (PubMed id 7607679)1, 2, 9 Grigoriou M.... Karagogeos D. (1995)
    3. Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10. (PubMed id 16335786)1, 2, 9 Lin J.... Wigle J.T. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    6. Inhibition of endothelial cell activation by the homeobox gene Gax. (PubMed id 12842453)1, 9 Gorski D.H. and Leal A.J. (2003)
    7. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. (PubMed id 16116430)1, 9 Wu Z....Zlokovic B.V. (2005)
    8. A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a. (PubMed id 19340300)1, 9 Irelan J.T....Chanda S.K. (2009)
    9. Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells. (PubMed id 22206000)1 Douville J.M....Wigle J.T. (2011)
    10. MEOX2 regulates nuclear factor-kappaB activity in vas cular endothelial cells through interactions with p65 and IkappaBbeta. (PubMed id 20421348)1 Chen Y....Gorski D.H. (2010)

    External Searches for MEOX2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MEOX2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4223 HGNC: 7014 AceView: MEOX2 Ensembl:ENSG00000106511 euGenes: HUgn4223
    ECgene: MEOX2 H-InvDB: MEOX2

    Other Databases showing MEOX2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MEOX2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MEOX2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MEOX2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MEOX2 gene:
    Search GeneIP for patents involving MEOX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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