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Aliases for MEOX2 Gene

Aliases for MEOX2 Gene

  • Mesenchyme Homeobox 2 2 3 4 5
  • Growth Arrest-Specific Homeobox 2 3 4
  • MOX2 3 4
  • GAX 3 4
  • Mesenchyme Homeo Box 2 (Growth Arrest-Specific Homeo Box) 2
  • Mesenchyme Homeobox 2 (Growth Arrest-Specific Homeo Box) 2

External Ids for MEOX2 Gene

Previous HGNC Symbols for MEOX2 Gene

  • GAX

Previous GeneCards Identifiers for MEOX2 Gene

  • GC07M015295
  • GC07M015395
  • GC07M015424

Summaries for MEOX2 Gene

Entrez Gene Summary for MEOX2 Gene

  • This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for MEOX2 Gene

MEOX2 (Mesenchyme Homeobox 2) is a Protein Coding gene. Diseases associated with MEOX2 include female stress incontinence and urethral intrinsic sphincter deficiency. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is HOXD3.

UniProtKB/Swiss-Prot for MEOX2 Gene

  • Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.

Gene Wiki entry for MEOX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEOX2 Gene

Genomics for MEOX2 Gene

Regulatory Elements for MEOX2 Gene

Promoters for MEOX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MEOX2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MEOX2 Gene

Chromosome:
7
Start:
15,611,212 bp from pter
End:
15,686,812 bp from pter
Size:
75,601 bases
Orientation:
Minus strand

Genomic View for MEOX2 Gene

Genes around MEOX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEOX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEOX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEOX2 Gene

Proteins for MEOX2 Gene

  • Protein details for MEOX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50222-MEOX2_HUMAN
    Recommended name:
    Homeobox protein MOX-2
    Protein Accession:
    P50222
    Secondary Accessions:
    • B2R8I7
    • O75263
    • Q9UPL6

    Protein attributes for MEOX2 Gene

    Size:
    304 amino acids
    Molecular mass:
    33594 Da
    Quaternary structure:
    • Interacts with RNF10.

neXtProt entry for MEOX2 Gene

Proteomics data for MEOX2 Gene at MOPED

Post-translational modifications for MEOX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MEOX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEOX2 Gene

Domains & Families for MEOX2 Gene

Gene Families for MEOX2 Gene

Suggested Antigen Peptide Sequences for MEOX2 Gene

Graphical View of Domain Structure for InterPro Entry

P50222

UniProtKB/Swiss-Prot:

MEOX2_HUMAN :
  • The polyhistidine repeat may act as a targeting signal to nuclear speckles.
Domain:
  • The polyhistidine repeat may act as a targeting signal to nuclear speckles.
  • Contains 1 homeobox DNA-binding domain.
genes like me logo Genes that share domains with MEOX2: view

Function for MEOX2 Gene

Molecular function for MEOX2 Gene

GENATLAS Biochemistry:
mesenchyme homeo box, murine Mox2,homolog
UniProtKB/Swiss-Prot Function:
Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.

Gene Ontology (GO) - Molecular Function for MEOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16335786
GO:0043565 sequence-specific DNA binding IEA,IMP 22206000
genes like me logo Genes that share ontologies with MEOX2: view
genes like me logo Genes that share phenotypes with MEOX2: view

Animal Models for MEOX2 Gene

MGI Knock Outs for MEOX2:

Animal Model Products

  • Taconic Biosciences Mouse Models for MEOX2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEOX2 Gene

Localization for MEOX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEOX2 Gene

Nucleus. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEOX2 Gene COMPARTMENTS Subcellular localization image for MEOX2 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for MEOX2 Gene

Pathways & Interactions for MEOX2 Gene

SuperPathways for MEOX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP 17074759
genes like me logo Genes that share ontologies with MEOX2: view

No data available for Pathways by source and SIGNOR curated interactions for MEOX2 Gene

Drugs & Compounds for MEOX2 Gene

(3) Drugs for MEOX2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for MEOX2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MEOX2: view

Transcripts for MEOX2 Gene

mRNA/cDNA for MEOX2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(72) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MEOX2 Gene

Mesenchyme homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEOX2 Gene

No ASD Table

Relevant External Links for MEOX2 Gene

GeneLoc Exon Structure for
MEOX2
ECgene alternative splicing isoforms for
MEOX2

Expression for MEOX2 Gene

mRNA expression in normal human tissues for MEOX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEOX2 Gene

This gene is overexpressed in Nerve - Tibial (x8.9), Adipose - Subcutaneous (x5.9), Artery - Tibial (x5.2), and Adipose - Visceral (Omentum) (x4.2).

Protein differential expression in normal tissues from HIPED for MEOX2 Gene

This gene is overexpressed in Fetal heart (61.6) and Placenta (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MEOX2 Gene



SOURCE GeneReport for Unigene cluster for MEOX2 Gene Hs.170355

mRNA Expression by UniProt/SwissProt for MEOX2 Gene

P50222-MEOX2_HUMAN
Tissue specificity: Embryo and placenta.
genes like me logo Genes that share expression patterns with MEOX2: view

Protein tissue co-expression partners for MEOX2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for MEOX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MEOX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEOX2 36
  • 100 (a)
OneToOne
MEOX2 35
  • 99.23 (n)
  • 99.34 (a)
cow
(Bos Taurus)
Mammalia MEOX2 36
  • 99 (a)
OneToOne
MEOX2 35
  • 93.95 (n)
  • 98.68 (a)
dog
(Canis familiaris)
Mammalia MEOX2 35
  • 93.29 (n)
  • 99.34 (a)
MEOX2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Meox2 16
Meox2 35
  • 89.44 (n)
  • 98.02 (a)
Meox2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MEOX2 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEOX2 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Meox2 35
  • 89.55 (n)
  • 97.69 (a)
chicken
(Gallus gallus)
Aves MEOX2 35
  • 84.11 (n)
  • 93.05 (a)
MEOX2 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEOX2 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia meox2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia meox2 35
  • 76.22 (n)
  • 84.67 (a)
Str.10254 35
zebrafish
(Danio rerio)
Actinopterygii MEOX2 (1 of 2) 36
  • 69 (a)
OneToMany
meox2b 36
  • 67 (a)
OneToMany
LOC556898 35
  • 66.21 (n)
  • 70.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta btn 36
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for MEOX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEOX2 Gene

ENSEMBL:
Gene Tree for MEOX2 (if available)
TreeFam:
Gene Tree for MEOX2 (if available)

Paralogs for MEOX2 Gene

(7) SIMAP similar genes for MEOX2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MEOX2: view

Variants for MEOX2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MEOX2 Gene

P50222-MEOX2_HUMAN
The poly-His region of MEOX2 is polymorphic and the number of His varies in the population.

Sequence variations from dbSNP and Humsavar for MEOX2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_049585 -
rs917438 -- 15,683,727(+) AGAAA(C/T)TATTG intron-variant
rs917439 -- 15,683,763(+) TTCAA(A/C)ATATC intron-variant
rs917440 -- 15,684,128(+) AGAAA(C/T)TTAAG intron-variant
rs3801429 -- 15,682,813(+) GTAAA(A/G)TTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEOX2 Gene

Variant ID Type Subtype PubMed ID
nsv523199 CNV Gain 19592680
nsv887735 CNV Loss 21882294
nsv464392 CNV Loss 19166990
nsv824016 CNV Loss 20364138
esv27709 CNV Loss 19812545
esv273709 CNV Insertion 20981092
nsv830911 CNV Gain 17160897
dgv7213n71 CNV Loss 21882294

Variation tolerance for MEOX2 Gene

Residual Variation Intolerance Score: 70.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.44; 71.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEOX2 Gene

HapMap Linkage Disequilibrium report
MEOX2
Human Gene Mutation Database (HGMD)
MEOX2

Disorders for MEOX2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for MEOX2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
female stress incontinence
  • female urinary stress incontinence
urethral intrinsic sphincter deficiency
  • intrinsic sphincter deficiency [isd]
low compliance bladder
  • hyperactivity of bladder
urethral syndrome
  • urethral disease
neurogenic bladder
  • neurogenic dysfunction of the urinary bladder
- elite association - COSMIC cancer census association via MalaCards
Search MEOX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MEOX2

Genetic Association Database (GAD)
MEOX2
Human Genome Epidemiology (HuGE) Navigator
MEOX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEOX2
genes like me logo Genes that share disorders with MEOX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEOX2 Gene

Publications for MEOX2 Gene

  1. Molecular cloning and localization of the human GAX gene to 7p21. (PMID: 7713505) Lepage D.F. … Walsh K. (Genomics 1994) 2 3 4 67
  2. A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a. (PMID: 19340300) Irelan J.T. … Chanda S.K. (PLoS ONE 2009) 3 23
  3. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. (PMID: 16116430) Wu Z. … Zlokovic B.V. (Nat. Med. 2005) 3 23
  4. Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10. (PMID: 16335786) Lin J. … Wigle J.T. (Mol. Cell. Biochem. 2005) 3 23
  5. Inhibition of endothelial cell activation by the homeobox gene Gax. (PMID: 12842453) Gorski D.H. … Leal A.J. (J. Surg. Res. 2003) 3 23

Products for MEOX2 Gene

Sources for MEOX2 Gene

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