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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MEOX2 Gene

protein-coding   GIFtS: 58
GCID: GC07M015617

Mesenchyme Homeobox 2

(Previous names: mesenchyme homeo box 2 (growth arrest-specific homeo box),...)
(Previous symbol: GAX)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mesenchyme Homeobox 21 2 3     Mesenchyme Homeo Box 2 (Growth Arrest-Specific Homeo Box)1
GAX1 2 3     Mesenchyme Homeobox 2 (Growth Arrest-Specific Homeo Box)1
Growth Arrest-Specific Homeobox1 2 3     Homeobox Protein MOX-22
MOX22 3     

External Ids:    HGNC: 70141   Entrez Gene: 42232   Ensembl: ENSG000001065117   OMIM: 6005355   UniProtKB: P502223   

Export aliases for MEOX2 gene to outside databases

Previous GC identifers: GC07M015295 GC07M015395 GC07M015424


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MEOX2 Gene:
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes.
The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related
mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular
dysfunction observed in Alzheimer's disease. (provided by RefSeq, Jul 2008)

GeneCards Summary for MEOX2 Gene: 
MEOX2 (mesenchyme homeobox 2) is a protein-coding gene. Diseases associated with MEOX2 include low compliance bladder, and urethral intrinsic sphincter deficiency. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MNX1.

UniProtKB/Swiss-Prot: MEOX2_HUMAN, P50222
Function: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and
sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the
cell cycle (By similarity)

Gene Wiki entry for MEOX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MEOX2 gene promoter:
         TBP   GATA-3   IRF-1   NF-kappaB   NF-kappaB1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMEOX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MEOX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEOX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1-p21.3   Ensembl cytogenetic band:  7p21.2   HGNC cytogenetic band: 7p22.1-p21.3

MEOX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEOX2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M015617:  view genomic region     (about GC identifiers)

Start:
15,650,837 bp from pter      End:
15,726,437 bp from pter
Size:
75,601 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 15,703,946-15,779,448     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MEOX2_HUMAN, P50222 (See protein sequence)
Recommended Name: Homeobox protein MOX-2  
Size: 304 amino acids; 33594 Da
Subunit: Interacts with RNF10
Subcellular location: Nucleus. Nucleus speckle
Secondary accessions: O75263 Q9UPL6

Explore the universe of human proteins at neXtProt for MEOX2: NX_P50222

Explore proteomics data for MEOX2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P50222

  • MEOX2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MEOX2 Protein Expression
    REFSEQ proteins: NP_005915.2  
    ENSEMBL proteins: 
     ENSP00000262041  

    Human Recombinant Protein Products for MEOX2: 
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    Novus Biologicals MEOX2 Proteins
    Novus Biologicals MEOX2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MEOX2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA16335786
    GO:0016607nuclear speck IEA--

    MEOX2 for ontologies           About GeneDecksing



    MEOX2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MEOX2
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    Cloud-Clone Corp. ELISAs for MEOX2 
    Cloud-Clone Corp. CLIAs for MEOX2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    4 InterPro protein domains:
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P50222

    ProtoNet protein and cluster: P50222

    1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: MEOX2_HUMAN, P50222
    Domain: The polyhistidine repeat may act as a targeting signal to nuclear speckles (PubMed:19266028)
    Similarity: Contains 1 homeobox DNA-binding domain


    MEOX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MEOX2_HUMAN, P50222
    Function: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and
    sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the
    cell cycle (By similarity)

         Genatlas biochemistry entry for MEOX2:
    mesenchyme homeo box, murine Mox2,homolog

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI16335786
    GO:0043565sequence-specific DNA binding IDA9073066
         
    MEOX2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MEOX2:
     Increased homologous recombina 

         15/25 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Meox2) (see all 25):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    MEOX2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Meox2tm1Vpa for MEOX2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MEOX2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MEOX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MEOX2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MEOX2 

    miRNA
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    miRTarBase miRNAs that target MEOX2:
    hsa-mir-301a (MIRT003611), hsa-mir-130a (MIRT004358)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEOX2
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate MEOX2 (see all 33):
    hsa-miR-2052 hsa-miR-19b-2* hsa-miR-15a hsa-miR-301a hsa-miR-424 hsa-miR-15b hsa-miR-130b hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidMEOX2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEOX2
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                         Customized lentivirus expression plasmids for stable overexpression of MEOX2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEOX2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MEOX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/20 Interacting proteins for MEOX2 (P502222, 3 ENSP000002620414) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SAMM50Q9Y5122, 3, ENSP000003454454MINT-67293 I2D: score=5 STRING: ENSP00000345445
    RND2P521982, 3MINT-67514 I2D: score=4 
    PAX3P237602, 3, ENSP000003759214MINT-15278 MINT-15279 I2D: score=5 STRING: ENSP00000375921
    HSPA2P546522, 3, ENSP000002472074MINT-2860884 I2D: score=3 STRING: ENSP00000247207
    VIPP012822, 3, ENSP000003562134MINT-68122 I2D: score=5 STRING: ENSP00000356213
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001757somite specification IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007275multicellular organismal development TAS7713505
    GO:0007519skeletal muscle tissue development IEA--

    MEOX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MEOX2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MEOX2

    4 Novoseek inferred chemical compound relationships for MEOX2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 43.4 2 12842453 (1), 15735029 (1)
    thymidine 32.6 3 9552512 (1), 12842453 (1), 8796105 (1)
    histidine 28.5 2 7607679 (1)
    nitric oxide 0 2 9552512 (1), 8796105 (1)

    Search CenterWatch for drugs/clinical trials and news about MEOX2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MEOX2 gene: 
    NM_005924.4  

    Unigene Cluster for MEOX2:

    Mesenchyme homeobox 2
    Hs.170355  [show with all ESTs]
    Unigene Representative Sequence: NM_005924
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000262041(uc003stc.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEOX2
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate MEOX2 (see all 33):
    hsa-miR-2052 hsa-miR-19b-2* hsa-miR-15a hsa-miR-301a hsa-miR-424 hsa-miR-15b hsa-miR-130b hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidMEOX2 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEOX2
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    GenScript: all cDNA clones in your preferred vector: MEOX2 (NM_005924)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEOX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEOX2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEOX2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEOX2

    Additional mRNA sequence: 

    AK309472.1 AK313386.1 BC017021.1 CR536553.1 L36328.1 X82629.1 

    5 DOTS entries:

    DT.312727  DT.100752325  DT.100752324  DT.102826664  DT.95267883 

    24/72 AceView cDNA sequences (see all 72):

    Z39263 AI523234 F02393 CD518172 AI467833 AW628626 CD621383 AA921812 
    CA405528 AU135401 CD621380 NM_005924 BF111571 CD621381 BF589409 BX090450 
    BU682093 AA489656 CD000982 BI524836 CD621379 BQ007850 AW662773 BM974745 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MEOX2 expression in normal human tissues (normalized intensities)      MEOX2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGAACAACT
    MEOX2 Expression
    About this image


    MEOX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 11 entries
             Sacral Brown Adipocyte Cells Sacral Brown Adipose Depot
             Body Subcutaneous White Adipose
             omental adipose tissue   
     
     Limb (Muscoskeletal System)    fully expand to see all 6 entries
             Limb Muscle Progenitor Cells Forelimb Myotome
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 6 entries
             Limb Muscle Progenitor Cells Forelimb Myotome
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             Renal Vesicle
     
     Peripheral Nervous System (Nervous System)
             Human Schwann Cells (HSC)   

    See MEOX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MEOX2

    SOURCE GeneReport for Unigene cluster: Hs.170355

    UniProtKB/Swiss-Prot: MEOX2_HUMAN, P50222
    Tissue specificity: Embryo and placenta

        SABiosciences Custom PCR Arrays for MEOX2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEOX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MEOX2 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Meox21 , 5 mesenchyme homeobox 21, 5 89.44(n)1
    98.02(a)1
      12 (16.84 cM)5
    172861  NM_008584.31  NP_032610.11 
     371085405 
    chicken
    (Gallus gallus)
    Aves MEOX21 mesenchyme homeobox 2 84.44(n)
    94.04(a)
      374137  NM_001005427.1  NP_001005427.1 
    lizard
    (Anolis carolinensis)
    Reptilia MEOX26
    Uncharacterized protein
    87(a)
    1 ↔ 1
    6(27051956-27123735)
    African clawed frog
    (Xenopus laevis)
    Amphibia meox2-prov2 mesenchyme homeobox 2 76.37(n)    BC044705.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5568981 homeobox protein MOX-2-like 66.55(n)
    72.16(a)
      556898  XM_679832.1  XP_684924.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta btn6
    CG156966
    --
    35(a)
    15(a)
    1 ↔ many
    possible ortholog
    3R(18411871-18412347)
    3R(16672833-16673372)
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-626
    ceh-126
    Homeobox protein ceh-12
    8(a)
    19(a)
    possible ortholog
    possible ortholog
    II(10805394-10809992)
    I(5840289-5841888)


    ENSEMBL Gene Tree for MEOX2 (if available)
    TreeFam Gene Tree for MEOX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MEOX2 gene
    MNX12  EVX12  MEOX12  GBX12  EVX22  GBX22  
    8 SIMAP similar genes for MEOX2 using alignment to 3 protein entries:     MEOX2_HUMAN (see all proteins):
    HOXC13    HOXA4    NKX6-1    HOX B6    HOXB1    POU6F1
    MEOX1    HHEX

    MEOX2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: MEOX2_HUMAN, P50222
    Polymorphism: The poly-His region of MEOX2 is polymorphic and the number of His varies in the population


    10/1745 SNPs in MEOX2 are shown (see all 1745)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1413787881,2
    --15623620(+) GCATCA/CTTTAC 1 -- ds50010--------
    rs69762021,2
    C,F,A,H--15623650(+) AGAACC/TGAGGA 1 -- ds500112Minor allele frequency- T:0.43NS EA WA NA CSA 786
    rs69562201,2
    C,F,A,H--15623669(+) AGCTTG/CTTTAG 1 -- ds500112Minor allele frequency- C:0.27NA WA CSA EA 510
    rs1469732821,2
    --15623687(+) TTCACA/GTCAGA 1 -- ds50010--------
    rs1868226441,2
    --15623696(+) GAGACA/TCTGCA 1 -- ds50010--------
    rs1928678291,2
    --15623714(+) ACTATA/GAAACC 1 -- ds50010--------
    rs1143567481,2
    F--15623727(+) TGTTGG/CATTAA 1 -- ds50011Minor allele frequency- C:0.05WA 118
    rs1409784831,2
    C--15623770(+) ATGAC-/TATTTTA 1 -- ds50010--------
    rs766730131,2
    C,F--15623825(+) TACTTT/ATATCT 1 -- ds50011Minor allele frequency- A:0.09WA 118
    rs1849069601,2
    --15623963(+) AAAAAA/TTTCAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MEOX2 (15650837 - 15726437 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for MEOX2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv273709CNV Insertion20981092
    nsv464392CNV Loss19166990
    nsv824016CNV Loss20364138
    nsv887735CNV Loss21882294
    dgv7213n71CNV Loss21882294
    esv27709CNV Loss19812545
    nsv523199CNV Gain19592680
    nsv830911CNV Gain17160897


    Human Gene Mutation Database (HGMD): MEOX2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MEOX2
    DNA2.0 Custom Variant and Variant Library Synthesis for MEOX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600535    OMIM disorders: --

    14 diseases for MEOX2:    About MalaCards
    low compliance bladder    urethral intrinsic sphincter deficiency    female stress incontinence    urethritis
    neurogenic bladder    portal hypertension    vesicoureteral reflux    alzheimer's disease
    human t-cell leukemia virus type 1    wilms tumor    t-cell leukemia    hypertension
    endotheliitis    leukemia

    5 diseases from the University of Copenhagen DISEASES database for MEOX2:
    Female stress incontinence     Urethral intrinsic sphincter deficiency     Vesicoureteral reflux     Neurogenic bladder
    Low compliance bladder

    MEOX2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for MEOX2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperplasia 17.6 2 9552512 (1), 8796105 (1)
    alzheimers disease 7.49 2 16116430 (2)

    Genetic Association Database (GAD): MEOX2
    Human Genome Epidemiology (HuGE) Navigator: MEOX2 (2 documents)

    Export disorders for MEOX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MEOX2 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with MEOX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and localization of the human GAX gene to 7p21. (PubMed id 7713505)1, 2, 3 Lepage D.F. and Walsh K. (1994)
    2. Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3. (PubMed id 7607679)1, 2, 9 Grigoriou M.... Karagogeos D. (1995)
    3. Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10. (PubMed id 16335786)1, 2, 9 Lin J.... Wigle J.T. (2005)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    7. Inhibition of endothelial cell activation by the homeobox gene Gax. (PubMed id 12842453)1, 9 Gorski D.H. and Leal A.J. (2003)
    8. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. (PubMed id 16116430)1, 9 Wu Z....Zlokovic B.V. (2005)
    9. A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a. (PubMed id 19340300)1, 9 Irelan J.T....Chanda S.K. (2009)
    10. Growth arrest-specific homeobox is associated with poo r survival in patients with hepatocellular carcinoma. (PubMed id 22644917)1 Zhou P....Wang Z.M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4223 HGNC: 7014 AceView: MEOX2 Ensembl:ENSG00000106511 euGenes: HUgn4223
    ECgene: MEOX2 H-InvDB: MEOX2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MEOX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MEOX2 gene:
    Search GeneIP for patents involving MEOX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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