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Aliases for MEOX2 Gene

Aliases for MEOX2 Gene

  • Mesenchyme Homeobox 2 2 3 4 5
  • Growth Arrest-Specific Homeobox 2 3 4
  • MOX2 3 4
  • GAX 3 4
  • Mesenchyme Homeo Box 2 (Growth Arrest-Specific Homeo Box) 2
  • Mesenchyme Homeobox 2 (Growth Arrest-Specific Homeo Box) 2
  • Homeobox Protein MOX-2 3

External Ids for MEOX2 Gene

Previous HGNC Symbols for MEOX2 Gene

  • GAX

Previous GeneCards Identifiers for MEOX2 Gene

  • GC07M015295
  • GC07M015395
  • GC07M015424

Summaries for MEOX2 Gene

Entrez Gene Summary for MEOX2 Gene

  • This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for MEOX2 Gene

MEOX2 (Mesenchyme Homeobox 2) is a Protein Coding gene. Diseases associated with MEOX2 include Female Stress Incontinence and Low Compliance Bladder. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is MEOX1.

UniProtKB/Swiss-Prot for MEOX2 Gene

  • Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.

Gene Wiki entry for MEOX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEOX2 Gene

Genomics for MEOX2 Gene

Regulatory Elements for MEOX2 Gene

Enhancers for MEOX2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MEOX2 on UCSC Golden Path with GeneCards custom track

Promoters for MEOX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MEOX2 Gene

Chromosome:
7
Start:
15,611,212 bp from pter
End:
15,686,812 bp from pter
Size:
75,601 bases
Orientation:
Minus strand

Genomic View for MEOX2 Gene

Genes around MEOX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEOX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEOX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEOX2 Gene

Proteins for MEOX2 Gene

  • Protein details for MEOX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50222-MEOX2_HUMAN
    Recommended name:
    Homeobox protein MOX-2
    Protein Accession:
    P50222
    Secondary Accessions:
    • B2R8I7
    • O75263
    • Q9UPL6

    Protein attributes for MEOX2 Gene

    Size:
    304 amino acids
    Molecular mass:
    33594 Da
    Quaternary structure:
    • Interacts with RNF10.

neXtProt entry for MEOX2 Gene

Post-translational modifications for MEOX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MEOX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEOX2 Gene

Domains & Families for MEOX2 Gene

Gene Families for MEOX2 Gene

Suggested Antigen Peptide Sequences for MEOX2 Gene

Graphical View of Domain Structure for InterPro Entry

P50222

UniProtKB/Swiss-Prot:

MEOX2_HUMAN :
  • The polyhistidine repeat may act as a targeting signal to nuclear speckles.
Domain:
  • The polyhistidine repeat may act as a targeting signal to nuclear speckles.
  • Contains 1 homeobox DNA-binding domain.
genes like me logo Genes that share domains with MEOX2: view

Function for MEOX2 Gene

Molecular function for MEOX2 Gene

GENATLAS Biochemistry:
mesenchyme homeo box, murine Mox2,homolog
UniProtKB/Swiss-Prot Function:
Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.

Gene Ontology (GO) - Molecular Function for MEOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 17074759
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA 17074759
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IMP 17074759
GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding IMP 17074759
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA 22206000
genes like me logo Genes that share ontologies with MEOX2: view
genes like me logo Genes that share phenotypes with MEOX2: view

Animal Models for MEOX2 Gene

MGI Knock Outs for MEOX2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEOX2 Gene

Localization for MEOX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEOX2 Gene

Nucleus. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEOX2 Gene COMPARTMENTS Subcellular localization image for MEOX2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for MEOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22206000
GO:0005737 cytoplasm IDA 16335786
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with MEOX2: view

Pathways & Interactions for MEOX2 Gene

SuperPathways for MEOX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001757 somite specification IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007275 multicellular organism development TAS 7713505
GO:0007519 skeletal muscle tissue development IEA --
genes like me logo Genes that share ontologies with MEOX2: view

No data available for Pathways by source and SIGNOR curated interactions for MEOX2 Gene

Drugs & Compounds for MEOX2 Gene

(3) Drugs for MEOX2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for MEOX2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MEOX2: view

Transcripts for MEOX2 Gene

mRNA/cDNA for MEOX2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(72) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MEOX2 Gene

Mesenchyme homeobox 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEOX2 Gene

No ASD Table

Relevant External Links for MEOX2 Gene

GeneLoc Exon Structure for
MEOX2
ECgene alternative splicing isoforms for
MEOX2

Expression for MEOX2 Gene

mRNA expression in normal human tissues for MEOX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEOX2 Gene

This gene is overexpressed in Nerve - Tibial (x8.9), Adipose - Subcutaneous (x5.9), Artery - Tibial (x5.2), and Adipose - Visceral (Omentum) (x4.2).

Protein differential expression in normal tissues from HIPED for MEOX2 Gene

This gene is overexpressed in Fetal heart (61.6) and Placenta (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MEOX2 Gene



Protein tissue co-expression partners for MEOX2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MEOX2 Gene:

MEOX2

SOURCE GeneReport for Unigene cluster for MEOX2 Gene:

Hs.170355

mRNA Expression by UniProt/SwissProt for MEOX2 Gene:

P50222-MEOX2_HUMAN
Tissue specificity: Embryo and placenta.
genes like me logo Genes that share expression patterns with MEOX2: view

Primer Products

Orthologs for MEOX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MEOX2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MEOX2 34
  • 93.95 (n)
  • 98.68 (a)
MEOX2 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEOX2 34
  • 93.29 (n)
  • 99.34 (a)
MEOX2 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Meox2 34
  • 89.44 (n)
  • 98.02 (a)
Meox2 16
Meox2 35
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MEOX2 34
  • 99.23 (n)
  • 99.34 (a)
MEOX2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Meox2 34
  • 89.55 (n)
  • 97.69 (a)
oppossum
(Monodelphis domestica)
Mammalia MEOX2 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEOX2 35
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves MEOX2 34
  • 84.11 (n)
  • 93.05 (a)
MEOX2 35
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEOX2 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia meox2 34
  • 76.22 (n)
  • 84.67 (a)
Str.10254 34
African clawed frog
(Xenopus laevis)
Amphibia meox2-prov 34
zebrafish
(Danio rerio)
Actinopterygii LOC556898 34
  • 66.21 (n)
  • 70.31 (a)
MEOX2 (1 of 2) 35
  • 69 (a)
OneToMany
meox2b 35
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta btn 35
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToMany
Species where no ortholog for MEOX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEOX2 Gene

ENSEMBL:
Gene Tree for MEOX2 (if available)
TreeFam:
Gene Tree for MEOX2 (if available)

Paralogs for MEOX2 Gene

Paralogs for MEOX2 Gene

(7) SIMAP similar genes for MEOX2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MEOX2: view

Variants for MEOX2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MEOX2 Gene

MEOX2_HUMAN-P50222
The poly-His region of MEOX2 is polymorphic and the number of His varies in the population.

Sequence variations from dbSNP and Humsavar for MEOX2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_049585 -
rs2237498 -- 15,684,532(+) CGTGA(C/G)AGAAG intron-variant
rs10224088 -- 15,683,310(+) ATTTT(C/T)TCTCA intron-variant
rs3801429 -- 15,682,813(+) GTAAA(A/G)TTTTG intron-variant
rs3801430 -- 15,683,211(+) AACAC(A/G)GTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEOX2 Gene

Variant ID Type Subtype PubMed ID
esv27709 CNV loss 19812545
esv3309437 CNV mobile element insertion 20981092
nsv1018250 CNV loss 25217958
nsv1161502 CNV duplication 26073780
nsv464392 CNV loss 19166990
nsv523199 CNV gain 19592680
nsv606283 CNV gain 21841781
nsv606310 CNV loss 21841781
nsv824016 CNV loss 20364138
nsv830911 CNV gain 17160897

Variation tolerance for MEOX2 Gene

Residual Variation Intolerance Score: 70.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.44; 71.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEOX2 Gene

Human Gene Mutation Database (HGMD)
MEOX2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEOX2

Disorders for MEOX2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MEOX2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
female stress incontinence
  • female urinary stress incontinence
low compliance bladder
  • hyperactivity of bladder
neurogenic bladder
  • neurogenic dysfunction of the urinary bladder
alzheimer disease
  • alzheimer disease, late-onset
- elite association - COSMIC cancer census association via MalaCards
Search MEOX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MEOX2

Genetic Association Database (GAD)
MEOX2
Human Genome Epidemiology (HuGE) Navigator
MEOX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEOX2
genes like me logo Genes that share disorders with MEOX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEOX2 Gene

Publications for MEOX2 Gene

  1. Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10. (PMID: 16335786) Lin J. … Wigle J.T. (Mol. Cell. Biochem. 2005) 3 4 22 65
  2. Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3. (PMID: 7607679) Grigoriou M. … Karagogeos D. (Genomics 1995) 3 4 22 65
  3. Molecular cloning and localization of the human GAX gene to 7p21. (PMID: 7713505) Lepage D.F. … Walsh K. (Genomics 1994) 2 3 4 65
  4. Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells. (PMID: 22206000) Douville J.M. … Wigle J.T. (PLoS ONE 2011) 3 4 65
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65

Products for MEOX2 Gene

Sources for MEOX2 Gene

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