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MEOX1 Gene

protein-coding GIFtS: 55
GCID: GC17M041728

Mesenchyme Homeobox 1

(Previous name: mesenchyme homeo box 1)

See MEOX1-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Mesenchyme Homeobox 1¹ ² ³
MOX1² ³ ⁵
KFS2² ⁵
Mesenchyme Homeo Box 1¹
Homeobox Protein MOX-1²

External Ids:	HGNC: 7013¹	Entrez Gene: 4222²	Ensembl: ENSG00000005102⁷	OMIM: 600147⁵	UniProtKB: P50221³

Export aliases for MEOX1 gene to outside databases

Previous GC identifers: GC17M041459 GC17M043894 GC17M042192 GC17M042189 GC17M039074 GC17M037482

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MEOX1 Gene:

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes.

The encoded protein may play a role in the molecular signaling network regulating somite development.

Alternatively spliced transcript variants encoding different isoforms have been described. (provided by RefSeq,

Jul 2008)

GeneCards Summary for MEOX1 Gene:

MEOX1 (mesenchyme homeobox 1) is a protein-coding gene. Diseases associated with MEOX1 include klippel-feil syndrome 2, and klippel-feil syndrome. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSX1.

UniProtKB/Swiss-Prot: MEOX1_HUMAN, P50221

Function: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and

sclerotomal differentiation (By similarity)

Gene Wiki entry for MEOX1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000017.10 NC_018928.2 NT_010783.16

Regulatory elements:

Regulatory transcription factor binding sites in the MEOX1 gene promoter:
MyoD
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MEOX1 promoter sequence

Search Chromatin IP Primers for MEOX1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEOX1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.31

MEOX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEOX1 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M041728: view genomic region (about GC identifiers)

Start:	41,717,756 bp from pter	End:	41,739,322 bp from pter
Size:	21,567 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: MEOX1_HUMAN, P50221 (See protein sequence)

Recommended Name: Homeobox protein MOX-1

Size: 254 amino acids; 27997 Da

Secondary accessions: A8MWF9 Q15069

Alternative splicing: 3 isoforms: P50221-1 P50221-2 P50221-3 (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for MEOX1: NX_P50221

Explore proteomics data for MEOX1 at MOPED

See MEOX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts):

NP_001035091.1 NP_004518.1 NP_054705.1

ENSEMBL proteins:

ENSP00000321684 ENSP00000449049 ENSP00000377271 ENSP00000328678

MEOX1 Human Recombinant Protein Products:

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	Search GeneTex for Proteins for MEOX1
	antibodies-online proteins for MEOX1 (11 products)
	antibodies-online peptides for MEOX1

MEOX1 Antibody Products:

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	antibodies-online antibodies for MEOX1 (41 products)

MEOX1 Assay Products:

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	antibodies-online kits for MEOX1 (4 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:

HOXL: Homeoboxes / ANTP class : HOXL subclass

4 InterPro protein domains:

IPR020479 Homeobox_metazoa

IPR017970 Homeobox_CS

IPR001356 Homeobox_dom

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry P50221

ProtoNet protein and cluster: P50221

1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

UniProtKB/Swiss-Prot: MEOX1_HUMAN, P50221

Similarity: Contains 1 homeobox DNA-binding domain

Find genes that share domains with MEOX1 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MEOX1_HUMAN, P50221

Function: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and

sclerotomal differentiation (By similarity)

Genatlas biochemistry entry for MEOX1:

mesenchyme homeo box, murine Mox1,homolog

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0003677	DNA binding	--	--
GO:0003682	chromatin binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

Find genes that share ontologies with MEOX1 About GenesLikeMe

Phenotypes:
13 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Meox1):

adipose tissue	craniofacial	embryogenesis	growth/size/body	homeostasis/metabolism
integument	limbs/digits/tail	mortality/aging	muscle	nervous system
no phenotypic analysis	normal	skeleton

Find genes that share phenotypes with MEOX1 About GenesLikeMe

Animal Models:
MGI mouse knock-out Meox1^tm1Bmk for MEOX1

genOway: Develop your customized and physiologically relevant rodent model for MEOX1

miRNA Products:		Block miRNA regulation of human, mouse, rat MEOX1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate MEOX1 (see all 16):
		hsa-miR-1226 hsa-miR-520d-5p hsa-miR-1285 hsa-miR-3171 hsa-miR-3692 hsa-miR-629* hsa-miR-3658 hsa-miR-24

		SwitchGear 3'UTR luciferase reporter plasmid: MEOX1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MEOX1
		Predesigned siRNA for gene silencing in human, mouse, rat MEOX1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MEOX1

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEOX1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

MEOX1_HUMAN, P50221: Nucleus (Potential)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	4

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005730	nucleolus	--	--

Find genes that share ontologies with MEOX1 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Pathway & Disease-focused RT² Profiler PCR Array including MEOX1:

Homeobox (HOX) Genes in human mouse rat

Interactions:

GeneGlobe Interaction Network for MEOX1

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for MEOX1 (P50221^{2, 3} ENSP00000321684⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PAX1	P15863²^,³, ENSP00000381499⁴	MINT-17255 MINT-17254 I2D: score=5 STRING: ENSP00000381499
PAX3	P23760³, ENSP00000375921⁴	I2D: score=4 STRING: ENSP00000375921
SOX10	P56693³, ENSP00000354130⁴	I2D: score=1 STRING: ENSP00000354130
--	G5E9C1³	I2D: score=1

About this table

Gene Ontology (GO): 5 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001757	somite specification	IEA	--
GO:0006355	regulation of transcription, DNA-templated	--	--
GO:0007275	multicellular organismal development	TAS	7987315
GO:0008150	biological_process	ND	--
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA	--

Find genes that share ontologies with MEOX1 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for MEOX1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for MEOX1 gene (3 alternative transcripts):

NM_001040002.1 NM_004527.3 NM_013999.3

Unigene Cluster for MEOX1:

Mesenchyme homeobox 1

Hs.438 [show with all ESTs]

Unigene Representative Sequence: NM_004527

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000318579(uc002idz.3 uc002iea.3 uc002ieb.3) ENST00000549132

ENST00000393661 ENST00000329168

miRNA Products:		Block miRNA regulation of human, mouse, rat MEOX1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate MEOX1 (see all 16):
		hsa-miR-1226 hsa-miR-520d-5p hsa-miR-1285 hsa-miR-3171 hsa-miR-3692 hsa-miR-629* hsa-miR-3658 hsa-miR-24

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		QuantiFast Probe-based Assays in human, mouse, rat MEOX1

Additional mRNA sequence:

AK291139.1 BC069474.1 BC069506.1 U10492.1 U10493.1

4 DOTS entries:

DT.86852568 DT.95356559 DT.95356560 DT.95356562

Selected AceView cDNA sequences (see all 65):

BC069506 BQ028272 BF057739 AI185722 AA424161 NM_004527 BG677020 BX284090

BC069474 NM_013999 AI808644 AU131390 BF511359 BE296796 CA406013 BQ003431

AI707783 U10493 AU120742 BE898972 U10492 BF307940 AI090595 AI375755

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for MEOX1 About this scheme

ExUns:	1	^	2	^	3a	·	3b
SP1:
SP2:			-

ECgene alternative splicing isoforms for MEOX1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MEOX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

MEOX1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 17) fully expand


Mesoderm (Gastrulation Derivatives) fully expand to see all 3 entries
Mesoderm Cells Mesoderm
Early mesoderm cells

Heart (Cardiovascular System) fully expand to see all 5 entries
Vascular Smooth Muscle Cells Dorsal Aorta
Atrioventricular Canal

Somite (Muscoskeletal System) fully expand to see all 2 entries
Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
Embryoid bodies

Intermediate Mesoderm (Gastrulation Derivatives) fully expand to see all 2 entries
Intermediate Mesoderm Cells Intermediate Mesoderm
Intermediate Mesoderm

NULL (Uncategorized) fully expand to see all 2 entries
Paraxial mesoderm cells

MEOX1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

MEOX1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.438

Pathway & Disease-focused RT² Profiler PCR Array including MEOX1:

Homeobox (HOX) Genes in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEOX1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MEOX1 gene from Selected species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Meox1^{1 , 5}	mesenchyme homeobox 1^{1, 5}	84.13(n)¹ 82.14(a)¹		11 (65.48 cM)⁵ 17285¹ NM_010791.3¹ NP_034921.1¹ 101877510⁵
chicken (Gallus gallus)	Aves	MEOX1¹	mesenchyme homeobox 1	68.47(n) 64.17(a)		395533 NM_204765.1 NP_990096.1
lizard (Anolis carolinensis)	Reptilia	MEOX1⁶	mesenchyme homeobox 1	61(a)	1 ↔ 1	6(78013024-78027695)
zebrafish (Danio rerio)	Actinopterygii	meox1¹	mesenchyme homeobox 1	62.83(n) 57.2(a)		436723 NM_001002450.2 NP_001002450.2
fruit fly (Drosophila melanogaster)	Insecta	btn⁶	buttonless	40(a)	1 → many	3R(18411871-18412347)

ENSEMBL Gene Tree for MEOX1 (if available)
TreeFam Gene Tree for MEOX1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for MEOX1 gene

GSX1² HOXA3² EVX2² HOXA1² HOXB1² HOXB3² HOXD1² HOXA2²

GSX2² EVX1² HOXB2² MEOX2² PDX1² HOXD3²

2 SIMAP similar genes for MEOX1 using alignment to 2 protein entries: MEOX1_HUMAN (see all proteins):

POU6F1 MEOX2

Find genes that share paralogs with MEOX1 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112448546^1,2	C	--	37488283(+)	`GAGGAAAAC/- AAATT`	3	--	int¹		1		CSA	2
rs143224431^1,2	C	--	37498734(+)	`TTTCT-/TTTC TTTCT`	3	--	int¹		0	--	--	--	--
rs10712114^1,2	C	--	37505368(+)	`ACTTC-/TTTTTT`	1	--	us2k¹ trp³		1		CSA	2
rs7226183^1,2	C,H	--	37505381(+)	`tttttT/Cctttt`	1	--	us2k¹ trp³		1		NA	2
rs58709943^1,2	C	--	41720055(+)	`ACAAA-/AACA A/ACAAAGGGCC`	3	--	int¹		1		NA	2
rs58390408^1,2	C	--	41720515(+)	`AAAAA-/ACAAAA`	3	--	int¹		1		CSA	2
rs139847579^1,2	C	--	41723980(+)	`TGAGG-/AAA A/ACAAAAATT`	3	--	int¹		0	--	--	--	--
rs72213620^1,2	C	--	41723982(+)	`AGGAA-/AAAC ATTTC`	3	--	int¹		0	--	--	--	--
rs60726674^1,2	C	--	41723983(+)	`GGAAAACAA/- TTTCA`	3	--	int¹		1		NA	2
rs67553599^1,2	C	--	41725851(-)	`TTTTC-/C/TTTTTT`	3	--	int¹		2		NA	4

HapMap Linkage Disequilibrium report for MEOX1 (41717756 - 41739322 bp)

Structural Variations
Database of Genomic Variants (DGV) 5 variations for MEOX1: About this table

Variant ID	Type	Subtype	PubMed ID
esv2715958	CNV	Deletion	23290073
nsv908266	CNV	Loss	21882294
nsv908265	CNV	Gain	21882294
nsv819106	CNV	Gain	19587683
nsv908264	CNV	Gain	21882294

Human Gene Mutation Database (HGMD): MEOX1

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing MEOX1

DNA2.0 Custom Variant and Variant Library Synthesis for MEOX1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 600147
OMIM disorders: 214300
6 diseases for MEOX1:
About MalaCards

klippel-feil syndrome 2 klippel-feil syndrome diaphanospondylodysostosis klippel-feil syndrome 3, autosomal dominant

3 inferred disease relationships from the University of Copenhagen DISEASES database for MEOX1:

Klippel-Feil syndrome Mesoblastic nephroma SOST-related sclerosing bone dysplasia

Find genes that share disorders with MEOX1 About GenesLikeMe

Genetic Association Database (GAD): MEOX1

Export disorders for MEOX1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MEOX1 gene, integrated from 10 sources (see all 15):
(articles sorted by number of sources associating them with MEOX1)

Utopia: connect your pdf to the dynamic
world of online information

Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture. (PubMed id 7987315)^{1, 2, 3, 9} Futreal P.A....Wiseman R.W. (Hum. Mol. Genet. 1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Mutations in MEOX1, encoding mesenchyme homeobox 1, cause Klippel-Feil anomaly. (PubMed id 23290072)¹ Mohamed J.Y....Alkuraya F.S. (Am. J. Hum. Genet. 2013)
Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites. (PubMed id 22567123)¹ Thiaville M.M....Wang T.L. (PLoS ONE 2012)
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (amp 2008)
Diaphanospondylodysostosis: six new cases and exclusion of the candidate genes, PAX1 and MEOX1. (PubMed id 17764081)¹ Vatanavicharn N....Wilcox W.R. (Am. J. Med. Genet. A 2007)
The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. (PubMed id 16582099)¹ WissmA1ller S....Wegner M. (Nucleic Acids Res. 2006)
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)² Zody M.C.... Nusbaum C. (Nature 2006)
Hedgehog signaling induces cardiomyogenesis in P19 cells. (PubMed id 15793308)¹ Gianakopoulos P.J. and Skerjanc I.S. (J. Biol. Chem. 2005)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4222	HGNC: 7013	AceView: MEOX1	Ensembl:ENSG00000005102	euGenes: HUgn4222
ECgene: MEOX1	H-InvDB: MEOX1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MEOX1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MEOX1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MEOX1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MEOX1 gene:
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GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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MEOX1 Gene

Mesenchyme Homeobox 1

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MEOX1 Gene

Mesenchyme Homeobox 1

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for MEOX1 gene

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for MEOX1 gene

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for MEOX1 gene

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for MEOX1 gene

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for MEOX1 gene

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for MEOX1 gene

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for MEOX1 gene

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for MEOX1 gene

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for MEOX1 gene

Intellectual Property
for MEOX1 gene

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for MEOX1 gene