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MEOX1 Gene

protein-coding   GIFtS: 55
GCID: GC17M041728

Mesenchyme Homeobox 1

(Previous name: mesenchyme homeo box 1)
  See MEOX1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mesenchyme Homeobox 11 2 3
MOX12 3 5
KFS22 5
Mesenchyme Homeo Box 11
Homeobox Protein MOX-12

External Ids:    HGNC: 70131   Entrez Gene: 42222   Ensembl: ENSG000000051027   OMIM: 6001475   UniProtKB: P502213   

Export aliases for MEOX1 gene to outside databases

Previous GC identifers: GC17M041459 GC17M043894 GC17M042192 GC17M042189 GC17M039074 GC17M037482


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MEOX1 Gene:
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes.
The encoded protein may play a role in the molecular signaling network regulating somite development.
Alternatively spliced transcript variants encoding different isoforms have been described. (provided by RefSeq,
Jul 2008)

GeneCards Summary for MEOX1 Gene:
MEOX1 (mesenchyme homeobox 1) is a protein-coding gene. Diseases associated with MEOX1 include klippel-feil syndrome 2, and klippel-feil syndrome 1, autosomal dominant. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSX1.

UniProtKB/Swiss-Prot: MEOX1_HUMAN, P50221
Function: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and
sclerotomal differentiation (By similarity)

Gene Wiki entry for MEOX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MEOX1 gene promoter:
         MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMEOX1 promoter sequence
   Search Chromatin IP Primers for MEOX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEOX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

MEOX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEOX1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M041728:  view genomic region     (about GC identifiers)

Start:
41,717,756 bp from pter      End:
41,739,322 bp from pter
Size:
21,567 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MEOX1_HUMAN, P50221 (See protein sequence)
Recommended Name: Homeobox protein MOX-1  
Size: 254 amino acids; 27997 Da
Secondary accessions: A8MWF9 Q15069
Alternative splicing: 3 isoforms:  P50221-1   P50221-2   P50221-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for MEOX1: NX_P50221

Explore proteomics data for MEOX1 at MOPED


See MEOX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001035091.1  NP_004518.1  NP_054705.1  

ENSEMBL proteins: 
 ENSP00000321684   ENSP00000449049   ENSP00000377271   ENSP00000328678  

MEOX1 Human Recombinant Protein Products:

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Novus Biologicals MEOX1 Proteins
Novus Biologicals MEOX1 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
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Cloud-Clone Corp. Proteins for MEOX1

 
Search eBioscience for Proteins for MEOX1 

MEOX1 Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of MEOX1
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Abcam antibodies for MEOX1
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ThermoFisher Antibodies for MEOX1
LSBio Antibodies in human, mouse, rat for MEOX1

MEOX1 Assay Products:

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Cloud-Clone Corp. ELISAs for MEOX1
Cloud-Clone Corp. CLIAs for MEOX1
Search eBioscience for ELISAs for MEOX1 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
HOXL: Homeoboxes / ANTP class : HOXL subclass

4 InterPro protein domains:
 IPR020479 Homeobox_metazoa
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry P50221

ProtoNet protein and cluster: P50221

1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

UniProtKB/Swiss-Prot: MEOX1_HUMAN, P50221
Similarity: Contains 1 homeobox DNA-binding domain


Find genes that share domains with MEOX1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: MEOX1_HUMAN, P50221
Function: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and
sclerotomal differentiation (By similarity)

     Genatlas biochemistry entry for MEOX1:
mesenchyme homeo box, murine Mox1,homolog

     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
GO:0003677DNA binding ----
GO:0003682chromatin binding IEA--
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding IEA--
     
Find genes that share ontologies with MEOX1           About GenesLikeMe


Phenotypes:
     13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Meox1):
 adipose tissue  craniofacial  embryogenesis  growth/size/body  homeostasis/metabolism 
 integument  limbs/digits/tail  mortality/aging  muscle  nervous system 
 no phenotypic analysis  normal  skeleton 

Find genes that share phenotypes with MEOX1           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Meox1tm1Bmk for MEOX1

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MEOX1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MEOX1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MEOX1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MEOX1

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat MEOX1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate MEOX1 (see all 16):
hsa-miR-1226 hsa-miR-520d-5p hsa-miR-1285 hsa-miR-3171 hsa-miR-3692 hsa-miR-629* hsa-miR-3658 hsa-miR-24
SwitchGear 3'UTR luciferase reporter plasmidMEOX1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for MEOX1
Predesigned siRNA for gene silencing in human, mouse, rat MEOX1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for MEOX1

Clone
Products:
     
OriGene clones in human, mouse for MEOX1 (see all 14)
OriGene ORF clones in mouse, rat for MEOX1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): MEOX1 (NM_001040002)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEOX1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEOX1

Cell Line
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GenScript Custom overexpressing Cell Line Services for MEOX1
Browse ESI BIO Cell Lines and PureStem Progenitors for MEOX1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEOX1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
MEOX1_HUMAN, P50221: Nucleus (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--
GO:0005730nucleolus ----

Find genes that share ontologies with MEOX1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Array including MEOX1: 
          Homeobox (HOX) Genes in human mouse rat

Interactions:

    GeneGlobe Interaction Network for MEOX1

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for MEOX1 (P502212, 3 ENSP000003216844) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
PAX1P158632, 3, ENSP000003814994MINT-17255 MINT-17254 I2D: score=5 STRING: ENSP00000381499
PAX3P237603, ENSP000003759214I2D: score=4 STRING: ENSP00000375921
SOX10P566933, ENSP000003541304I2D: score=1 STRING: ENSP00000354130
--G5E9C13I2D: score=1 
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001757somite specification IEA--
GO:0006355regulation of transcription, DNA-templated ----
GO:0007275multicellular organismal development TAS7987315
GO:0008150biological_process ND--
GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--

Find genes that share ontologies with MEOX1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MEOX1



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MEOX1 gene (3 alternative transcripts): 
NM_001040002.1  NM_004527.3  NM_013999.3  

Unigene Cluster for MEOX1:

Mesenchyme homeobox 1
Hs.438  [show with all ESTs]
Unigene Representative Sequence: NM_004527
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000318579(uc002idz.3 uc002iea.3 uc002ieb.3) ENST00000549132
ENST00000393661 ENST00000329168
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat MEOX1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate MEOX1 (see all 16):
hsa-miR-1226 hsa-miR-520d-5p hsa-miR-1285 hsa-miR-3171 hsa-miR-3692 hsa-miR-629* hsa-miR-3658 hsa-miR-24
SwitchGear 3'UTR luciferase reporter plasmidMEOX1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for MEOX1
Predesigned siRNA for gene silencing in human, mouse, rat MEOX1
Clone
Products:
     
OriGene clones in human, mouse for MEOX1 (see all 14)
OriGene ORF clones in mouse, rat for MEOX1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): MEOX1 (NM_001040002)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEOX1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEOX1
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for MEOX1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MEOX1
  QuantiTect SYBR Green Assays in human, mouse, rat MEOX1
  QuantiFast Probe-based Assays in human, mouse, rat MEOX1

Additional mRNA sequence: 

AK291139.1 BC069474.1 BC069506.1 U10492.1 U10493.1 

4 DOTS entries:

DT.86852568  DT.95356559  DT.95356560  DT.95356562 

Selected AceView cDNA sequences (see all 65):

BC069506 BQ028272 BF057739 AI185722 AA424161 NM_004527 BG677020 BX284090 
BC069474 NM_013999 AI808644 AU131390 BF511359 BE296796 CA406013 BQ003431 
AI707783 U10493 AU120742 BE898972 U10492 BF307940 AI090595 AI375755 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for MEOX1    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:                        
SP2:        -               


ECgene alternative splicing isoforms for MEOX1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MEOX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MEOX1 Expression
About this image


MEOX1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 17) fully expand
 
 Mesoderm (Gastrulation Derivatives)    fully expand to see all 3 entries
         Mesoderm Cells Mesoderm
         Early mesoderm cells
 
 Heart (Cardiovascular System)    fully expand to see all 5 entries
         Vascular Smooth Muscle Cells Dorsal Aorta
         Atrioventricular Canal
 
 Somite (Muscoskeletal System)    fully expand to see all 2 entries
         Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
         Embryoid bodies
 
 Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
         Intermediate Mesoderm Cells Intermediate Mesoderm
         Intermediate Mesoderm
 
 NULL (Uncategorized)    fully expand to see all 2 entries
         Paraxial mesoderm cells
MEOX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MEOX1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.438
    Pathway & Disease-focused RT2 Profiler PCR Array including MEOX1: 
          Homeobox (HOX) Genes in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for MEOX1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MEOX1
QuantiTect SYBR Green Assays in human, mouse, rat MEOX1
QuantiFast Probe-based Assays in human, mouse, rat MEOX1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEOX1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for MEOX1 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Meox11 , 5 mesenchyme homeobox 11, 5 84.13(n)1
82.14(a)1
  11 (65.48 cM)5
172851  NM_010791.31  NP_034921.11 
 1018775105 
chicken
(Gallus gallus)
Aves MEOX11 mesenchyme homeobox 1 68.47(n)
64.17(a)
  395533  NM_204765.1  NP_990096.1 
lizard
(Anolis carolinensis)
Reptilia MEOX16
mesenchyme homeobox 1
61(a)
1 ↔ 1
6(78013024-78027695)
zebrafish
(Danio rerio)
Actinopterygii meox11 mesenchyme homeobox 1 62.83(n)
57.2(a)
  436723  NM_001002450.2  NP_001002450.2 
fruit fly
(Drosophila melanogaster)
Insecta btn6
buttonless
40(a)
1 → many
3R(18411871-18412347)


ENSEMBL Gene Tree for MEOX1 (if available)
TreeFam Gene Tree for MEOX1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MEOX1 gene
GSX12  HOXA32  EVX22  HOXA12  HOXB12  HOXB32  HOXD12  HOXA22  
GSX22  EVX12  HOXB22  MEOX22  PDX12  HOXD32  
2 SIMAP similar genes for MEOX1 using alignment to 2 protein entries:     MEOX1_HUMAN (see all proteins):
POU6F1    MEOX2

Find genes that share paralogs with MEOX1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MEOX1 (see all 582)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1124485461,2
C--37488283(+) GAGGAAAAC/-  
        
AAATT
3 -- int11Minor allele frequency- -:0.50CSA 2
rs1432244311,2
C--37498734(+) TTTCT-/TTTC  
        
TTTCT
3 -- int10--------
rs107121141,2
C--37505368(+) ACTTC-/TTTTTT 1 -- us2k1 trp31Minor allele frequency- T:0.00CSA 2
rs72261831,2
C,H--37505381(+) tttttT/Cctttt 1 -- us2k1 trp31Minor allele frequency- C:0.00NA 2
rs587099431,2
C--41720055(+) ACAAA-/AACA  
 A
/ACAAA
GGGCC
3 -- int11NA 2
rs583904081,2
C--41720515(+) AAAAA-/ACAAAA 3 -- int11Minor allele frequency- A:0.50CSA 2
rs1398475791,2
C--41723980(+) TGAGG-/AAA   
  A
/ACAA
AAATT
3 -- int10--------
rs722136201,2
C--41723982(+) AGGAA-/AAAC  
        
ATTTC
3 -- int10--------
rs607266741,2
C--41723983(+) GGAAAACAA/-  
        
TTTCA
3 -- int11Minor allele frequency- -:0.00NA 2
rs675535991,2
C--41725851(-) TTTTC-/C/TTTTTT 3 -- int12NA 4

HapMap Linkage Disequilibrium report for MEOX1 (41717756 - 41739322 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for MEOX1:    About this table    
Variant IDTypeSubtypePubMed ID
esv2715958CNV Deletion23290073
nsv908266CNV Loss21882294
nsv908265CNV Gain21882294
nsv819106CNV Gain19587683
nsv908264CNV Gain21882294

Human Gene Mutation Database (HGMD): MEOX1
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MEOX1
DNA2.0 Custom Variant and Variant Library Synthesis for MEOX1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 600147   
OMIM disorders: 214300  
6 diseases for MEOX1:    
About MalaCards
klippel-feil syndrome 2    klippel-feil syndrome 1, autosomal dominant    diaphanospondylodysostosis    klippel-feil syndrome
sost-related sclerosing bone dysplasia    mesoblastic nephroma

3 diseases from the University of Copenhagen DISEASES database for MEOX1:
Klippel-Feil syndrome     Mesoblastic nephroma     SOST-related sclerosing bone dysplasia

Find genes that share disorders with MEOX1           About GenesLikeMe

Genetic Association Database (GAD): MEOX1

Export disorders for MEOX1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MEOX1 gene, integrated from 10 sources (see all 15):
(articles sorted by number of sources associating them with MEOX1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture. (PubMed id 7987315)1, 2, 3, 9 Futreal P.A....Wiseman R.W. (Hum. Mol. Genet. 1994)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Mutations in MEOX1, encoding mesenchyme homeobox 1, cause Klippel-Feil anomaly. (PubMed id 23290072)1 Mohamed J.Y....Alkuraya F.S. (Am. J. Hum. Genet. 2013)
  4. Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites. (PubMed id 22567123)1 Thiaville M.M....Wang T.L. (PLoS ONE 2012)
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
  7. Diaphanospondylodysostosis: six new cases and exclusion of the candidate genes, PAX1 and MEOX1. (PubMed id 17764081)1 Vatanavicharn N....Wilcox W.R. (Am. J. Med. Genet. A 2007)
  8. The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. (PubMed id 16582099)1 WissmA1ller S....Wegner M. (Nucleic Acids Res. 2006)
  9. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
  10. Hedgehog signaling induces cardiomyogenesis in P19 cells. (PubMed id 15793308)1 Gianakopoulos P.J. and Skerjanc I.S. (J. Biol. Chem. 2005)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4222 HGNC: 7013 AceView: MEOX1 Ensembl:ENSG00000005102 euGenes: HUgn4222
ECgene: MEOX1 H-InvDB: MEOX1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MEOX1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MEOX1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MEOX1 gene:
Search GeneIP for patents involving MEOX1

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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