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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MEOX1 Gene

protein-coding   GIFtS: 56
GCID: GC17M041728

mesenchyme homeobox 1

(Previous name: mesenchyme homeo box 1 )
 Explore 3 diseases affiliated with
MEOX1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MEOX1    

Aliases
for MEOX1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mesenchyme Homeobox 11 2 3
MOX11 2 3 5
Mesenchyme Homeo Box 11
KFS22
Homeobox Protein MOX-12

External Ids:    HGNC: 70131   Entrez Gene: 42222   Ensembl: ENSG000000051027   OMIM: 6001475   UniProtKB: P502213   

Export aliases for MEOX1 gene to outside databases

Previous GC identifers: GC17M041459 GC17M043894 GC17M042192 GC17M042189 GC17M039074 GC17M037482


Summaries
for MEOX1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MEOX1:
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The
encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively
spliced transcript variants encoding different isoforms have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MEOX1_HUMAN, P50221
Function: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and
sclerotomal differentiation (By similarity)

Gene Wiki entry for MEOX1


Genomic Views
for MEOX1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MEOX1 gene promoter:
         MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MEOX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MEOX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEOX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

MEOX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEOX1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M041728:  view genomic region     (about GC identifiers)

Start:
 41,717,756 bp from pter      End:
 41,739,322 bp from pter
Size:
 21,567 bases      Orientation:
 minus strand

Proteins
for MEOX1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MEOX1_HUMAN, P50221 (See protein sequence)
Recommended Name: Homeobox protein MOX-1  
Size: 254 amino acids; 27997 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q15069
Alternative splicing: 2 isoforms:  P50221-1   P50221-2   

Explore the universe of human proteins at neXtProt for MEOX1: NX_P50221

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P50221

    • MEOX1 Protein expression data from MOPED and PaxDb:    About this image 
    MEOX1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001035091.1  NP_004518.1  NP_054705.1  

    ENSEMBL proteins: 
     ENSP00000321684   ENSP00000449049   ENSP00000377271   ENSP00000328678  

    Human Recombinant Protein Products for MEOX1: 
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    OriGene Purified Protein: MEOX1
    OriGene Protein Over-expression Lysate (see all 3): MEOX1
    OriGene Custom Protein Services for MEOX1 
    GenScript Custom Purified and Recombinant Proteins Services for MEOX1
    Novus Biologicals MEOX1 Proteins
    Novus Biologicals MEOX1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MEOX1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ----
    GO:0005634nucleus ----
    GO:0005730nucleolus IDA--

    MEOX1 for ontologies           About GeneDecksing



    MEOX1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MEOX1
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    Uscn Antibodies for MEOX1
    ThermoFisher Antibodies for MEOX1

    Assay Products for MEOX1: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for MEOX1

    Protein Domains /
    Families
    for MEOX1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MEOX1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P50221

    ProtoNet protein and cluster: P50221

    1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: MEOX1_HUMAN, P50221
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for MEOX1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MEOX1_HUMAN, P50221
    Function: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and
    sclerotomal differentiation (By similarity)

         Genatlas biochemistry entry for MEOX1:
    mesenchyme homeo box, murine Mox1,homolog

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0071837HMG box domain binding IEA--
         
    MEOX1 for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Meox1):
     adipose tissue  craniofacial  embryogenesis  growth/size  homeostasis/metabolism 
     integument  limbs/digits/tail  mortality/aging  muscle  nervous system 
     no phenotypic analysis  skeleton 

    MEOX1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Meox1tm1Bmk for MEOX1
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MEOX1 

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEOX1
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate MEOX1 (see all 16):
    hsa-miR-1226 hsa-miR-520d-5p hsa-miR-1285 hsa-miR-3171 hsa-miR-3692 hsa-miR-629* hsa-miR-3658 hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmid: MEOX1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEOX1 (see all 7)
    OriGene shRNA RFP: MEOX1
    OriGene siRNA: MEOX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEOX1
    Sirion Biotech Custom design and validation of potent shRNA sequences against MEOX1 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MEOX1
    Sirion Biotech Customized adenovirus for overexpression of MEOX1 
    Sirion Biotech Customized adenovirus for potent knockdown of MEOX1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEOX1 (see all 5)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): MEOX1 (NM_001040002)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEOX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEOX1 

    Cell Line
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    Search LifeMap BioReagents cell lines for MEOX1
    Sirion Biotech Customized stable knockdown cell line services for MEOX1 
    Sirion Biotech Customized inducible knockdown cell line services for MEOX1
    Sirion Biotech Customized stable overexpressing cell line services for MEOX1
    Sirion Biotech Customized inducible overexpressing cell line services for MEOX1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEOX1


    Pathways & Interactions
    for MEOX1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MEOX1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for MEOX1 (P502212, 3 ENSP000003216844) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAX1P158632, 3, ENSP000003814994MINT-17255 MINT-17254 I2D: score=5 STRING: ENSP00000381499
    PAX3P237603, ENSP000003759214I2D: score=4 STRING: ENSP00000375921
    SOX10P566933, ENSP000003541304I2D: score=1 STRING: ENSP00000354130
    --G5E9C13I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001757somite specification IEA--
    GO:0007275multicellular organismal development TAS7987315
    GO:0008150biological_process ND--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--

    MEOX1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MEOX1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MEOX1
    Search CenterWatch for drugs/clinical trials and news about MEOX1 

    Transcripts
    for MEOX1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MEOX1 gene (3 alternative transcripts): 
    NM_001040002.1  NM_004527.3  NM_013999.3  

    Unigene Cluster for MEOX1:

    Mesenchyme homeobox 1
    Hs.438  [show with all ESTs]
    Unigene Representative Sequence: NM_004527
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000318579(uc002idz.3 uc002iea.3 uc002ieb.3) ENST00000549132
    ENST00000393661 ENST00000329168

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEOX1
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate MEOX1 (see all 16):
    hsa-miR-1226 hsa-miR-520d-5p hsa-miR-1285 hsa-miR-3171 hsa-miR-3692 hsa-miR-629* hsa-miR-3658 hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmid: MEOX1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEOX1 (see all 7)
    OriGene shRNA RFP: MEOX1
    OriGene siRNA: MEOX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEOX1
    Sirion Biotech Custom design and validation of potent shRNA sequences against MEOX1 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEOX1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEOX1 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): MEOX1 (NM_001040002)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEOX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEOX1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEOX1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MEOX1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEOX1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEOX1

    Additional cDNA sequence: 

    AK291139.1 BC069474.1 BC069506.1 U10492.1 U10493.1 

    4 DOTS entries:

    DT.86852568  DT.95356559  DT.95356560  DT.95356562 

    24/65 AceView cDNA sequences (see all 65):

    BQ028272 NM_004527 AA424161 BX284090 BC069474 BC069506 AI185722 BF057739 
    NM_013999 BG677020 BQ881894 BF511359 BF307940 AI378323 AU131390 AW410292 
    AU128418 AI090595 BE746990 AI638033 BE898972 CA406013 AU120742 BE296796 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MEOX1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b
    SP1:                        
    SP2:        -               


    ECgene alternative splicing isoforms for MEOX1

    Expression
    for MEOX1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MEOX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    MEOX1 Expression
    About this image

    MEOX1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    SomiteThoracic Ventrolateral Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    HeartAtrioventricular CanalHeart
    HeartAtrioventricular Endocardial CushionHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 9 LifeMap Cells 
    NameCategory
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    Paraxial mesoderm cells (Generation of human ...)
    Early mesoderm cells (Generation of human ...)
    Embryoid bodies (Generation of skelet...)
    Embryoid bodies (Generation of adipoc...)
    Nkx2-1 GFP+ cells (Efficient derivation...)
    Podocalyxin+, CD24+, GCTM2- (Derivation and sorti...)
    Mesendoderm (Derivation and sorti...)
    Podocalyxin+, CD24+, GCTM2 (low) (Derivation and sorti...)

    See MEOX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MEOX1

    SOURCE GeneReport for Unigene cluster: Hs.438
        SABiosciences Expression via Pathway-Focused PCR Array including MEOX1: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEOX1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEOX1

    Orthologs
    for MEOX1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MEOX1 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MEOX11 mesenchyme homeobox 1 68.47(n)
    64.17(a)    		   395533  NM_204765.1  NP_990096.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MEOX16
    		 --
    		 58(a)
    		 1 ↔ 1
    		 6(78016197-78027246)
    zebrafish
    (Danio rerio)    		 Actinopterygii meox11 mesenchyme homeobox 1 62.83(n)
    57.2(a)    		   436723  NM_001002450.2  NP_001002450.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta btn6
    		 buttonless
    		 33(a)
    		 1 → many
    		 3R(18411871-18412347)
    worm
    (Caenorhabditis elegans)    		 Secernentea ceh-126
    		 Homeobox protein ceh-12
    		 20(a)
    		 possible ortholog
    		 I(5840292-5841891)


    ENSEMBL Gene Tree for MEOX1 (if available)
    TreeFam Gene Tree for MEOX1 (if available) 

    Paralogs
    for MEOX1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MEOX1 gene
    NKX1-22  EVX22  GBX12  NKX1-12  GBX22  MNX12  EVX12  MEOX22  
    18/41 SIMAP similar genes for MEOX1 using alignment to 3 protein entries:     MEOX1_HUMAN (see all proteins) (see all similar genes):
    HOXC13    HOXB13    HOXD13    HHEX    HOXD11    HOXA4
    DRGX    HOXD12    GSX2    MNX1    HOXB8    DBX2
    HOX B6    EVX1    MSX1    HOXB1    MEOX2    PITX1

    MEOX1 for paralogs           About GeneDecksing



    Genomic Variants
    for MEOX1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/474 NCBI SNPs in MEOX1 are shown (see all 474)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1149778231,2
    		C,F--41717262(+) AAGACA/GTTGCT 3 -- ds5001 int11Minor allele frequency- G:0.02WA 118
    rs344404131,2
    		C--41717303(+) AAAAAA/-GACAA 3 -- int1 ds50011Minor allele frequency- -:0.00NA 2
    rs556749201,2
    		C,F--41717427(+) ATTAGG/AGATGG 3 -- int1 ds50012Minor allele frequency- A:0.24NA EA 240
    rs1467245491,2
    		--41717627(+) AAAAAC/TTAAAG 3 -- ds5001 int10--------
    rs1873552411,2
    		--41717676(+) CTTGCA/TTCTAG 3 -- ds5001 int10--------
    rs1404069871,2
    		--41717682(+) TCTAGA/GCATTG 3 -- int1 ds50010--------
    rs1441278281,2
    		--41717813(+) GAGCTC/TGCACA 3 -- ut310--------
    rs1464279841,2
    		--41717872(+) AAATCA/TTGCTC 3 -- ut310--------
    rs1490257121,2
    		--41718018(+) ACACCA/GGCTGG 3 -- ut310--------
    rs114221,2
    		C,F,H--41718063(-) TGGGGG/AACTGA 3 -- ut31 ese310Minor allele frequency- A:0.25EA MN NS NA CSA 2344

    HapMap Linkage Disequilibrium report for MEOX1 (41717756 - 41739322 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for MEOX1
         1 CNV: 58793
         1 Indel: 60233

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEOX1
    DNA2.0 Custom Variant and Variant Library Synthesis for MEOX1

    Disorders / Diseases
    for MEOX1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MEOX1 for disorders           About GeneDecksing

    OMIM gene information: 600147    OMIM disorders: --

    3 diseases for MEOX1:    About MalaCards
    sost-related sclerosing bone dysplasia    mesoblastic nephroma    diaphanospondylodysostosis

    3 diseases from the University of Copenhagen DISEASES database for MEOX1:
    Klippel-Feil syndrome     SOST-related sclerosing bone dysplasia     Mesoblastic nephroma

    Export disorders for MEOX1 gene to outside databases

    Publications
    for MEOX1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MEOX1 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with MEOX1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture. (PubMed id 7987315)1, 2, 3, 9 Futreal P.A....Wiseman R.W. (1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites. (PubMed id 22567123)1 Thiaville M.M....Wang T.L. (2012)
    4. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    6. Diaphanospondylodysostosis: six new cases and exclusion of the candidate genes, PAX1 and MEOX1. (PubMed id 17764081)1 Vatanavicharn N....Wilcox W.R. (2007)
    7. The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. (PubMed id 16582099)1 Wissmuller S....Wegner M. (2006)
    8. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    9. Hedgehog signaling induces cardiomyogenesis in P19 cells. (PubMed id 15793308)1 Gianakopoulos P.J. and Skerjanc I.S. (2005)
    10. Disruption of Meox or Gli activity ablates skeletal myogenesis in P19 cells. (PubMed id 15039437)1 Petropoulos H....Skerjanc I.S. (2004)

    External Searches for MEOX1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing MEOX1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4222 HGNC: 7013 AceView: MEOX1 Ensembl:ENSG00000005102 euGenes: HUgn4222
    ECgene: MEOX1 H-InvDB: MEOX1

    Other Databases showing MEOX1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MEOX1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MEOX1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MEOX1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MEOX1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MEOX1 gene:
    Search GeneIP for patents involving MEOX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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