Aliases for MEOX1 Gene
Aliases for MEOX1 Gene
External Ids for MEOX1 Gene
- HGNC: 7013
- Entrez Gene: 4222
- Ensembl: ENSG00000005102
- OMIM: 600147
- UniProtKB: P50221
Previous GeneCards Identifiers for MEOX1 Gene
- GC17M041459
- GC17M043894
- GC17M041728
- GC17M042192
- GC17M042189
- GC17M039074
- GC17M037482
Summaries for MEOX1 Gene
-
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for MEOX1 Gene
MEOX1 (Mesenchyme Homeobox 1) is a Protein Coding gene. Diseases associated with MEOX1 include Klippel-Feil Syndrome 2 and Isolated Klippel-Feil Syndrome. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is MEOX2.
UniProtKB/Swiss-Prot for MEOX1 Gene
-
Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEOX1 Gene
Genomics for MEOX1 Gene
Regulatory Elements for MEOX1 Gene
Enhancers for MEOX1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MEOX1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the MEOX1 gene promoter:
Regulatory Element Products
Genomic Location for MEOX1 Gene
- Chromosome:
- 17
- Start:
- 43,640,388 bp from pter
- End:
- 43,661,954 bp from pter
- Size:
- 21,567 bases
- Orientation:
- Minus strand
Genomic View for MEOX1 Gene
Genes around MEOX1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.31 by Ensembl
- 17q21.31 by Entrez Gene
- 17q21.31 by HGNC
MEOX1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MEOX1 Gene
Proteins for MEOX1 Gene
-
Protein details for MEOX1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P50221-MEOX1_HUMAN
- Recommended name:
- Homeobox protein MOX-1
- Protein Accession:
- P50221
- A8K524
- A8MWF9
- Q15069
Protein attributes for MEOX1 Gene
- Size:
- 254 amino acids
- Molecular mass:
- 27997 Da
- Quaternary structure:
- No Data Available
Protein Expression for MEOX1 Gene
Post-translational modifications for MEOX1 Gene
Other Protein References for MEOX1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for MEOX1
- Novus Biologicals Antibodies for MEOX1
- Invitrogen Antibodies for MEOX1
- antibodies-online Antibodies for MEOX1: See all 73
- GeneTex MEOX1 antibody for MEOX1
-
Custom Antibody ServicesProSci Antibodies for MEOX1
-
Santa Cruz Biotechnology (SCBT) Antibodies for MEOX1
Protein Products
-
OriGene Purified Proteins for MEOX1
- Search Origene for MassSpec and Protein Over-expression Lysates for MEOX1
- Origene Custom Protein Services for MEOX1
- antibodies-online Proteins for MEOX1: See all 12
- Search antibodies-online for peptides
- Search GeneTex for Proteins for MEOX1
Assay Products
No data available for DME Specific Peptides for MEOX1 Gene
Domains & Families for MEOX1 Gene
Gene Families for MEOX1 Gene
Protein Domains for MEOX1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MEOX1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for MEOX1 Gene
Function for MEOX1 Gene
Molecular function for MEOX1 Gene
- GENATLAS Biochemistry:
- mesenchyme homeo box, murine Mox1,homolog
- UniProtKB/Swiss-Prot Function:
- Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IEA | -- |
| GO:0001046 | core promoter sequence-specific DNA binding | ISS | -- |
| GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | IBA | -- |
| GO:0003674 | molecular_function | ND | -- |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for MEOX1 Gene
- MGI mutant phenotypes for MEOX1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for MEOX1:
Animal Models for MEOX1 Gene
- MGI Knock Outs for MEOX1:
-
- Meox1 tm1Bmk
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for MEOX1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MEOX1 gene
- Search ViGene Biosciences for MEOX1
CRISPR Products
-
OriGene CRISPR knockouts for MEOX1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MEOX1
- GenScript: Design CRISPR guide RNA sequences for MEOX1
miRNA for MEOX1 Gene
- miRTarBase miRNAs that target MEOX1
miRNA Products
- Search ViGene Biosciences for MEOX1
Inhibitory RNA Products
- Origene shRNA products in human, mouse, rat for MEOX1
- Browse OriGene Inhibitory RNA Products For MEOX1
-
ViGene Biosciences ready-to-package AAV shRNAs for MEOX1 gene
Clone Products
- Sino Biological Human cDNA Clone for MEOX1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for MEOX1
-
ViGene Biosciences adenoviral particle packaged cDNA for MEOX1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MEOX1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MEOX1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MEOX1 Gene
Localization for MEOX1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MEOX1 Gene
- Nucleus. Cytoplasm. Note=Localizes predominantly in the nucleus. {ECO:0000250 UniProtKB:P32442}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,ISS | -- |
| GO:0005737 | cytoplasm | ISS | -- |
Pathways & Interactions for MEOX1 Gene
No Data Available
Interacting Proteins for MEOX1 Gene
Selected Interacting proteins:
ENSP00000321684
P50221-MEOX1_HUMAN
for MEOX1 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001757 | somite specification | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription from RNA polymerase II promoter | IEA | -- |
| GO:0007275 | multicellular organism development | TAS | 7987315 |
No data available for Pathways by source and SIGNOR curated interactions for MEOX1 Gene
Transcripts for MEOX1 Gene
mRNA/cDNA for MEOX1 Gene
- (4) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (65) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for MEOX1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MEOX1
- GenScript: Design CRISPR guide RNA sequences for MEOX1
miRNA Products
- Search ViGene Biosciences for MEOX1
Inhibitory RNA Products
- Origene shRNA products in human, mouse, rat for MEOX1
- Browse OriGene Inhibitory RNA Products For MEOX1
-
ViGene Biosciences ready-to-package AAV shRNAs for MEOX1 gene
Clone Products
- Sino Biological Human cDNA Clone for MEOX1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | - |
Expression for MEOX1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Atrioventricular Node Cells Atrioventricular Node
- Vascular Smooth Muscle Cells Dorsal Aorta
- Atrioventricular Endocardial Cushion
- Atrioventricular Canal
- Outflow Tract
-
Mesoderm (Gastrulation Derivatives)
- Intermediate Mesoderm Cells Intermediate Mesoderm
- Mesoderm Cells Mesoderm
- Early mesoderm cells(Cheung C et. al. 2012)
-
Intermediate Mesoderm (Gastrulation Derivatives)
- Intermediate Mesoderm Cells Intermediate Mesoderm
- Intermediate Mesoderm
-
Somite (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
- Embryoid bodies(Ryan T et. al. 2012)
- NULL (Uncategorized)
-
Head Mesenchyme (Muscoskeletal System)
- Cardiac Neural Crest Cells Branchial Arch 3,4,6
-
Neural Crest (Gastrulation Derivatives)
- Cardiac Neural Crest Cells Branchial Arch 3,4,6
-
Kidney (Urinary System)
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
-
Blood (Hematopoietic System)
- T Helper Cells Peripheral Blood
-
Smooth Muscle (Muscoskeletal System)
- Vascular Smooth Muscle Cells Dorsal Aorta
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Gonad
- Primordial Germ Cells Allantois
- Lateral Plate Mesoderm (Gastrulation Derivatives)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for MEOX1 Gene
This gene is overexpressed in Adipose - Subcutaneous (x6.9), Adipose - Visceral (Omentum) (x5.3), and Breast - Mammary Tissue (x4.6).
This gene is overexpressed in Adipocyte (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MEOX1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MEOX1 Gene:
MEOX1SOURCE GeneReport for Unigene cluster for MEOX1 Gene:
Hs.438Evidence on tissue expression from TISSUES for MEOX1 Gene
- Muscle(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MEOX1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
Organs:
Head and neck:
- brain
- ear
- eye
- face
- forehead
- head
- lip
- middle ear
- mouth
- neck
- outer ear
- scalp
- skull
Thorax:
- chest wall
- clavicle
- heart
- lung
- rib
- rib cage
- scapula
Pelvis:
- pelvis
Limb:
- arm
- humerus
- shoulder
- upper limb
General:
- blood vessel
- hair
- skin
- spinal column
- spinal cord
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for MEOX1
No data available for mRNA Expression by UniProt/SwissProt for MEOX1 Gene
Orthologs for MEOX1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MEOX1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | MEOX1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | MEOX1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Meox1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Meox1 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MEOX1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MEOX1 34 |
|
||
| GGMOXR1 35 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | MEOX1 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | meox1 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | btn 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for MEOX1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MEOX1 Gene
Variants for MEOX1 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs713993044 | Pathogenic | 43,661,285(-) | CTGAG(C/T)AGCAC | reference, stop-gained, utr-variant-5-prime | |
| rs79213434 | Benign | 43,661,524(+) | TGGCC(A/G)CGGGA | intron-variant, reference, missense | |
| rs9898682 | Benign | 43,661,455(+) | CTTCC(A/G)AGTGG | intron-variant, reference, missense | |
| rs1000599253 | -- | 43,652,121(+) | AGAGG(C/G)ATACT | intron-variant | |
| rs1000618085 | -- | 43,663,862(+) | GCACC(A/C/T)GCCAC | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2715958 | CNV | deletion | 23290073 |
| esv7256 | CNV | gain | 19470904 |
| nsv1060861 | CNV | gain | 25217958 |
| nsv1146669 | OTHER | inversion | 26484159 |
| nsv819106 | CNV | gain | 19587683 |
Residual Variation Intolerance Score:
95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.09;
80.46% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for MEOX1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEOX1 Gene
Disorders for MEOX1 Gene
(5) MalaCards diseases for MEOX1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| klippel-feil syndrome 2 |
|
|
| isolated klippel-feil syndrome |
|
|
| klippel-feil syndrome |
|
|
| diaphanospondylodysostosis |
|
|
| van buchem disease |
|
|
Search MEOX1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MEOX1_HUMAN- Klippel-Feil syndrome 2, autosomal recessive (KFS2) [MIM:214300]: A skeletal disorder characterized by congenital fusion of cervical vertebrae. It is due to a failure in the normal segmentation of vertebrae during the early weeks of fetal development. The clinical triad consists of short neck, low posterior hairline, and limited neck movement. {ECO:0000269 PubMed:23290072, ECO:0000269 PubMed:24073994}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for MEOX1
No data available for Genatlas for MEOX1 Gene
Publications for MEOX1 Gene
- Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture. (PMID: 7987315) Futreal P.A. … Wiseman R.W. (Hum. Mol. Genet. 1994) 2 3 4 22 64
- Mutation in MEOX1 gene causes a recessive Klippel-Feil syndrome subtype. (PMID: 24073994) Bayrakli F. … Kars H.Z. (BMC Genet. 2013) 3 4 64
- Mutations in MEOX1, encoding mesenchyme homeobox 1, cause Klippel-Feil anomaly. (PMID: 23290072) Mohamed J.Y. … Alkuraya F.S. (Am. J. Hum. Genet. 2013) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N. … Vidal M. (Cell 2015) 3 64
Products for MEOX1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody ServicesOriGene Antibodies for MEOX1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MEOX1
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- OriGene qPCR primer pairs for MEOX1
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- GenScript: Design CRISPR guide RNA sequences for MEOX1
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- CloneReady with Over 120,000 Genes
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- Plasmid Preparation
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- Sino Biological Human cDNA Clone for MEOX1
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- Sino Biological Antibodies
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for MEOX1
- Novus Biologicals proteins and lysates for MEOX1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for MEOX1: See all 73
- Search antibodies-online for kits
- antibodies-online Proteins for MEOX1: See all 12
- Search antibodies-online for peptides
- GeneTex MEOX1 antibody for MEOX1
- Search GeneTex for Proteins for MEOX1
- ViGene Biosciences adenoviral particle packaged cDNA for MEOX1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MEOX1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MEOX1 gene
- Search ViGene Biosciences for MEOX1
- Santa Cruz Biotechnology (SCBT) Antibodies for MEOX1
- Search Santa Cruz Biotechnology (SCBT) for MEOX1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MEOX1
- Custom Antibody ServicesProSci Antibodies for MEOX1
- Search for MEOX1 Proteins at ProSci
- Horizon Cell Lines for MEOX1
- Cyagen custom Knockout/knockin (KOKI) mouse models for MEOX1
- VectorBuilder custom plasmid, inducible vectors for MEOX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MEOX1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MEOX1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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