Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MEOX1 Gene

protein-coding   GIFtS: 57
GCID: GC17M041728

Mesenchyme Homeobox 1

(Previous name: mesenchyme homeo box 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mesenchyme Homeobox 11 2 3
MOX12 3 5
Mesenchyme Homeo Box 11
KFS22
Homeobox Protein MOX-12

External Ids:    HGNC: 70131   Entrez Gene: 42222   Ensembl: ENSG000000051027   OMIM: 6001475   UniProtKB: P502213   

Export aliases for MEOX1 gene to outside databases

Previous GC identifers: GC17M041459 GC17M043894 GC17M042192 GC17M042189 GC17M039074 GC17M037482


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MEOX1 Gene:
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes.
The encoded protein may play a role in the molecular signaling network regulating somite development.
Alternatively spliced transcript variants encoding different isoforms have been described. (provided by RefSeq,
Jul 2008)

GeneCards Summary for MEOX1 Gene: 
MEOX1 (mesenchyme homeobox 1) is a protein-coding gene. Diseases associated with MEOX1 include diaphanospondylodysostosis, and sost-related sclerosing bone dysplasia. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MNX1.

UniProtKB/Swiss-Prot: MEOX1_HUMAN, P50221
Function: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and
sclerotomal differentiation (By similarity)

Gene Wiki entry for MEOX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MEOX1 gene promoter:
         MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMEOX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MEOX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEOX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

MEOX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEOX1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M041728:  view genomic region     (about GC identifiers)

Start:
41,717,756 bp from pter      End:
41,739,322 bp from pter
Size:
21,567 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MEOX1_HUMAN, P50221 (See protein sequence)
Recommended Name: Homeobox protein MOX-1  
Size: 254 amino acids; 27997 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: A8MWF9 Q15069
Alternative splicing: 3 isoforms:  P50221-1   P50221-2   P50221-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for MEOX1: NX_P50221

Explore proteomics data for MEOX1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P50221

  • MEOX1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MEOX1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001035091.1  NP_004518.1  NP_054705.1  

    ENSEMBL proteins: 
     ENSP00000321684   ENSP00000449049   ENSP00000377271   ENSP00000328678  

    Human Recombinant Protein Products for MEOX1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MEOX1
    OriGene Protein Over-expression Lysate for MEOX1
    OriGene MassSpec for MEOX1 
    OriGene Custom Protein Services for MEOX1
    GenScript Custom Purified and Recombinant Proteins Services for MEOX1
    Novus Biologicals MEOX1 Proteins
    Novus Biologicals MEOX1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MEOX1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--

    MEOX1 for ontologies           About GeneDecksing



    MEOX1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MEOX1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MEOX1
    GenScript Custom Superior Antibodies Services for MEOX1
    Novus Biologicals MEOX1 Antibodies
    Abcam antibodies for MEOX1
    Cloud-Clone Corp. Antibodies for MEOX1 
    ThermoFisher Antibodies for MEOX1
    LSBio Antibodies in human, mouse, rat for MEOX1 

    Assay Products for MEOX1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MEOX1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MEOX1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MEOX1 
    Cloud-Clone Corp. CLIAs for MEOX1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    4 InterPro protein domains:
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P50221

    ProtoNet protein and cluster: P50221

    1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: MEOX1_HUMAN, P50221
    Similarity: Contains 1 homeobox DNA-binding domain


    MEOX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MEOX1_HUMAN, P50221
    Function: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and
    sclerotomal differentiation (By similarity)

         Genatlas biochemistry entry for MEOX1:
    mesenchyme homeo box, murine Mox1,homolog

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    MEOX1 for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Meox1):
     adipose tissue  craniofacial  embryogenesis  growth/size  homeostasis/metabolism 
     integument  limbs/digits/tail  mortality/aging  muscle  nervous system 
     no phenotypic analysis  skeleton 

    MEOX1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Meox1tm1Bmk for MEOX1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MEOX1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MEOX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MEOX1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MEOX1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEOX1
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate MEOX1 (see all 16):
    hsa-miR-1226 hsa-miR-520d-5p hsa-miR-1285 hsa-miR-3171 hsa-miR-3692 hsa-miR-629* hsa-miR-3658 hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidMEOX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MEOX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEOX1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MEOX1
    Sirion Biotech Customized adenovirus for overexpression of MEOX1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MEOX1 (see all 14)
    OriGene ORF clones in mouse, rat for MEOX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MEOX1 (NM_001040002)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEOX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEOX1
    Sirion Biotech Customized lentivirus for stable overexpression of MEOX1 
                         Customized lentivirus expression plasmids for stable overexpression of MEOX1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MEOX1
    Search LifeMap BioReagents cell lines for MEOX1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEOX1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MEOX1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for MEOX1 (P502212, 3 ENSP000003216844) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAX1P158632, 3, ENSP000003814994MINT-17255 MINT-17254 I2D: score=5 STRING: ENSP00000381499
    PAX3P237603, ENSP000003759214I2D: score=4 STRING: ENSP00000375921
    SOX10P566933, ENSP000003541304I2D: score=1 STRING: ENSP00000354130
    --G5E9C13I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001757somite specification IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007275multicellular organismal development TAS7987315
    GO:0008150biological_process ND--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--

    MEOX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MEOX1

    Search CenterWatch for drugs/clinical trials and news about MEOX1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MEOX1 gene (3 alternative transcripts): 
    NM_001040002.1  NM_004527.3  NM_013999.3  

    Unigene Cluster for MEOX1:

    Mesenchyme homeobox 1
    Hs.438  [show with all ESTs]
    Unigene Representative Sequence: NM_004527
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000318579(uc002idz.3 uc002iea.3 uc002ieb.3) ENST00000549132
    ENST00000393661 ENST00000329168
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEOX1
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate MEOX1 (see all 16):
    hsa-miR-1226 hsa-miR-520d-5p hsa-miR-1285 hsa-miR-3171 hsa-miR-3692 hsa-miR-629* hsa-miR-3658 hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidMEOX1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MEOX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEOX1
    Clone
    Products:
         
    OriGene clones in human, mouse for MEOX1 (see all 14)
    OriGene ORF clones in mouse, rat for MEOX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MEOX1 (NM_001040002)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEOX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEOX1
    Sirion Biotech Customized lentivirus for stable overexpression of MEOX1 
                         Customized lentivirus expression plasmids for stable overexpression of MEOX1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MEOX1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MEOX1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEOX1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEOX1

    Additional mRNA sequence: 

    AK291139.1 BC069474.1 BC069506.1 U10492.1 U10493.1 

    4 DOTS entries:

    DT.86852568  DT.95356559  DT.95356560  DT.95356562 

    24/65 AceView cDNA sequences (see all 65):

    BX284090 NM_004527 NM_013999 BC069506 BC069474 BG677020 AA424161 BQ028272 
    BF057739 AI185722 AU120742 U10493 AU128418 AW410292 BE898972 BQ003431 
    AI375755 AI808644 BF307940 AI378323 BF511359 AI707783 U10492 AU131390 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MEOX1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b
    SP1:                        
    SP2:        -               


    ECgene alternative splicing isoforms for MEOX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MEOX1 expression in normal human tissues (normalized intensities)      MEOX1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MEOX1 Expression
    About this image


    MEOX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 5 entries
             Vascular Smooth Muscle Cells Dorsal Aorta
             Atrioventricular Canal
     
     Mesoderm (Gastrulation Derivatives)    fully expand to see all 3 entries
             Mesoderm Cells Mesoderm
             Mesoderm
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 2 entries
             Cardiac Neural Crest Cells Branchial Arch 3,4,6
             mandibular prominence tissue e12.5   
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Intermediate Mesoderm Cells Intermediate Mesoderm
             Intermediate Mesoderm
     
     Smooth Muscle (Muscoskeletal System)
             Vascular Smooth Muscle Cells Dorsal Aorta

    See MEOX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MEOX1

    SOURCE GeneReport for Unigene cluster: Hs.438
        SABiosciences Expression via Pathway-Focused PCR Array including MEOX1: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MEOX1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MEOX1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEOX1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEOX1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEOX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MEOX1 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Meox11 , 5 mesenchyme homeobox 11, 5 84.13(n)1
    82.14(a)1
      11 (65.48 cM)5
    172851  NM_010791.31  NP_034921.11 
     1018775105 
    chicken
    (Gallus gallus)
    Aves MEOX11 mesenchyme homeobox 1 68.47(n)
    64.17(a)
      395533  NM_204765.1  NP_990096.1 
    lizard
    (Anolis carolinensis)
    Reptilia MEOX16
    Uncharacterized protein
    61(a)
    1 ↔ 1
    6(78013024-78027695)
    zebrafish
    (Danio rerio)
    Actinopterygii meox11 mesenchyme homeobox 1 62.83(n)
    57.2(a)
      436723  NM_001002450.2  NP_001002450.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta btn6
    CG156966
    --
    34(a)
    16(a)
    many → 1
    possible ortholog
    3R(18411871-18412347)
    3R(16672833-16673372)
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-126
    ceh-626
    Uncharacterized homeobox protein R06F6.6
    24(a)
    10(a)
    possible ortholog
    possible ortholog
    I(5840289-5841888)
    II(10805394-10809992)


    ENSEMBL Gene Tree for MEOX1 (if available)
    TreeFam Gene Tree for MEOX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MEOX1 gene
    MNX12  EVX12  GBX12  EVX22  MEOX22  GBX22  
    2 SIMAP similar genes for MEOX1 using alignment to 2 protein entries:     MEOX1_HUMAN (see all proteins):
    POU6F1    MEOX2

    MEOX1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/582 SNPs in MEOX1 are shown (see all 582)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1124485461,2
    C--37488283(+) GAGGAAAAC/-  
            
    AAATT
    3 -- int11Minor allele frequency- -:0.50CSA 2
    rs1432244311,2
    C--37498734(+) TTTCT-/TTTC  
            
    TTTCT
    3 -- int10--------
    rs107121141,2
    C--37505368(+) ACTTC-/TTTTTT 1 -- us2k1 trp31Minor allele frequency- T:0.00CSA 2
    rs72261831,2
    C,H--37505381(+) tttttT/Cctttt 1 -- us2k1 trp31Minor allele frequency- C:0.00NA 2
    rs587099431,2
    C--41720055(+) ACAAA-/AACA  
     A
    /ACAAA
    GGGCC
    3 -- int11NA 2
    rs583904081,2
    C--41720515(+) AAAAA-/ACAAAA 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs1398475791,2
    C--41723980(+) TGAGG-/AAA   
      A
    /ACAA
    AAATT
    3 -- int10--------
    rs722136201,2
    C--41723982(+) AGGAA-/AAAC  
            
    ATTTC
    3 -- int10--------
    rs607266741,2
    C--41723983(+) GGAAAACAA/-  
            
    TTTCA
    3 -- int11Minor allele frequency- -:0.00NA 2
    rs675535991,2
    C--41725851(-) TTTTC-/C/TTTTTT 3 -- int12NA 4

    HapMap Linkage Disequilibrium report for MEOX1 (41717756 - 41739322 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MEOX1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2715958CNV Deletion23290073
    nsv908266CNV Loss21882294
    nsv908265CNV Gain21882294
    nsv819106CNV Gain19587683
    nsv908264CNV Gain21882294


    Human Gene Mutation Database (HGMD): MEOX1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MEOX1
    DNA2.0 Custom Variant and Variant Library Synthesis for MEOX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600147    OMIM disorders: --

    4 diseases for MEOX1:    About MalaCards
    diaphanospondylodysostosis    sost-related sclerosing bone dysplasia    klippel-feil syndrome    mesoblastic nephroma

    3 diseases from the University of Copenhagen DISEASES database for MEOX1:
    Klippel-Feil syndrome     Mesoblastic nephroma     SOST-related sclerosing bone dysplasia

    MEOX1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MEOX1

    Export disorders for MEOX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MEOX1 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with MEOX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture. (PubMed id 7987315)1, 2, 3, 9 Futreal P.A....Wiseman R.W. (1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Mutations in MEOX1, encoding mesenchyme homeobox 1, ca use Klippel-Feil anomaly. (PubMed id 23290072)1 Mohamed J.Y....Alkuraya F.S. (2013)
    4. Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites. (PubMed id 22567123)1 Thiaville M.M....Wang T.L. (2012)
    5. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    7. Diaphanospondylodysostosis: six new cases and exclusion of the candidate genes, PAX1 and MEOX1. (PubMed id 17764081)1 Vatanavicharn N....Wilcox W.R. (2007)
    8. The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. (PubMed id 16582099)1 Wissmuller S....Wegner M. (2006)
    9. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    10. Hedgehog signaling induces cardiomyogenesis in P19 cells. (PubMed id 15793308)1 Gianakopoulos P.J. and Skerjanc I.S. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4222 HGNC: 7013 AceView: MEOX1 Ensembl:ENSG00000005102 euGenes: HUgn4222
    ECgene: MEOX1 H-InvDB: MEOX1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MEOX1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MEOX1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MEOX1 gene:
    Search GeneIP for patents involving MEOX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of MEOX1
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MEOX1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for MEOX1  
     OriGene MassSpec something-or-other for MEOX1   OriGene clones in human, mouse for MEOX1  
     OriGene qSTAR qPCR primer pairs in human, mouse for MEOX1   OriGene Purified Protein for MEOX1  
     OriGene ORF clones in mouse, rat for MEOX1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MEOX1   OriGene Custom Protein Services for MEOX1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MEOX1
     QIAGEN SeqTarget long-range PCR primers for resequencing MEOX1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEOX1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEOX1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEOX1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEOX1
     GenScript Custom Purified and Recombinant Proteins Services for MEOX1 GenScript cDNA clones with any tag delivered in your preferred vector for MEOX1
     GenScript Custom Assay Services for MEOX1 GenScript Custom Superior Antibodies Services for MEOX1
     GenScript Custom overexpressing Cell Line Services for MEOX1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MEOX1 promoter
     Search Chromatin IP Primers for MEOX1
     RT2 qPCR Primer Assay in human, mouse, rat MEOX1
     GNC Network for MEOX1
     SABiosciences PCR Arrays including human, mouse, rat MEOX1
     Search Tocris compounds for MEOX1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MEOX1 antibodies
     MEOX1 proteins
     MEOX1 lysates
     Antibodies for MEOX1
     See all of Abcam's Antibodies, Kits and Proteins for MEOX1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for MEOX1
     Antibodies for MEOX1
     ELISAs for MEOX1
     CLIAs for MEOX1
     Search LifeMap BioReagents cell lines for MEOX1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEOX1
     SwitchGear 3'UTR luciferase reporter plasmids for MEOX1
     SwitchGear Promoter luciferase reporter plasmids for MEOX1
     ThermoFisher Antibodies for MEOX1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEOX1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MEOX1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MEOX1
    Customized:
     lentivirus for stable overexpression of MEOX1
     lentivirus expression plasmids for stable overexpression of MEOX1
     adenovirus for overexpression of MEOX1
     LSBio Antibodies in human, mouse, rat for MEOX1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MEOX1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4