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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MEOX1 Gene

protein-coding GIFtS: 57
GCID: GC17M041728

Mesenchyme Homeobox 1

(Previous name: mesenchyme homeo box 1)

4 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Mesenchyme Homeobox 1¹ ² ³
MOX1² ³ ⁵
Mesenchyme Homeo Box 1¹
KFS2²
Homeobox Protein MOX-1²

External Ids:	HGNC: 7013¹	Entrez Gene: 4222²	Ensembl: ENSG00000005102⁷	OMIM: 600147⁵	UniProtKB: P50221³

Export aliases for MEOX1 gene to outside databases

Previous GC identifers: GC17M041459 GC17M043894 GC17M042192 GC17M042189 GC17M039074 GC17M037482

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MEOX1 Gene:

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The

encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively

spliced transcript variants encoding different isoforms have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for MEOX1 Gene:

MEOX1 (mesenchyme homeobox 1) is a protein-coding gene. Diseases associated with MEOX1 include diaphanospondylodysostosis, and sost-related sclerosing bone dysplasia. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MNX1.

UniProtKB/Swiss-Prot: MEOX1_HUMAN, P50221

Function: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and

sclerotomal differentiation (By similarity)

Gene Wiki entry for MEOX1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.2 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MEOX1 gene promoter:
MyoD
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MEOX1 promoter sequence

Search SABiosciences Chromatin IP Primers for MEOX1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEOX1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.31

MEOX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEOX1 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M041728: view genomic region (about GC identifiers)

Start:	41,717,756 bp from pter	End:	41,739,322 bp from pter
Size:	21,567 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MEOX1_HUMAN, P50221 (See protein sequence)

Recommended Name: Homeobox protein MOX-1

Size: 254 amino acids; 27997 Da

Subcellular location: Nucleus (Potential)

Secondary accessions: A8MWF9 Q15069

Alternative splicing: 3 isoforms: P50221-1 P50221-2 P50221-3 (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for MEOX1: NX_P50221

Explore proteomics data for MEOX1 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P50221

MEOX1 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (3 alternative transcripts):

NP_001035091.1 NP_004518.1 NP_054705.1

ENSEMBL proteins:

ENSP00000321684 ENSP00000449049 ENSP00000377271 ENSP00000328678

Human Recombinant Protein Products for MEOX1:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for MEOX1 OriGene Protein Over-expression Lysate for MEOX1 OriGene MassSpec for MEOX1 OriGene Custom Protein Services for MEOX1
	GenScript Custom Purified and Recombinant Proteins Services for MEOX1
	Novus Biologicals MEOX1 Proteins Novus Biologicals MEOX1 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for MEOX1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005730	nucleolus	IDA	--

MEOX1 for ontologies About GeneDecksing

MEOX1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MEOX1
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	GenScript Custom Superior Antibodies Services for MEOX1
	Novus Biologicals MEOX1 Antibodies
	Abcam antibodies for MEOX1
	Cloud-Clone Corp. Antibodies for MEOX1
	ThermoFisher Antibodies for MEOX1
	LSBio Antibodies in human, mouse, rat for MEOX1

Assay Products for MEOX1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for MEOX1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MEOX1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for MEOX1 Cloud-Clone Corp. CLIAs for MEOX1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

HOXL: Homeoboxes / ANTP class : HOXL subclass

4 InterPro protein domains:

IPR020479 Homeobox_metazoa

IPR017970 Homeobox_CS

IPR001356 Homeodomain

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry P50221

ProtoNet protein and cluster: P50221

1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

UniProtKB/Swiss-Prot: MEOX1_HUMAN, P50221

Similarity: Contains 1 homeobox DNA-binding domain

MEOX1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MEOX1_HUMAN, P50221

Function: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and

sclerotomal differentiation (By similarity)

Genatlas biochemistry entry for MEOX1:

mesenchyme homeo box, murine Mox1,homolog

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0003677	DNA binding	--	--
GO:0003682	chromatin binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

MEOX1 for ontologies About GeneDecksing

Phenotypes:
12 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Meox1):

adipose tissue	craniofacial	embryogenesis	growth/size	homeostasis/metabolism
integument	limbs/digits/tail	mortality/aging	muscle	nervous system
no phenotypic analysis	skeleton

MEOX1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Meox1^tm1Bmk for MEOX1

inGenious Targeting Laboratory - Custom generated mouse model solutions for MEOX1

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MEOX1

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEOX1
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate MEOX1 (see all 16):
		hsa-miR-1226 hsa-miR-520d-5p hsa-miR-1285 hsa-miR-3171 hsa-miR-3692 hsa-miR-629* hsa-miR-3658 hsa-miR-24

		SwitchGear 3'UTR luciferase reporter plasmid: MEOX1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for MEOX1
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		Sirion Biotech Custom design and validation of potent shRNA sequences against MEOX1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for MEOX1
			Sirion Biotech Customized adenovirus for overexpression of MEOX1 Customized adenovirus for potent knockdown of MEOX1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for MEOX1 (see all 14) OriGene ORF clones in mouse, rat for MEOX1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): MEOX1 (NM_001040002)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MEOX1
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		Sirion Biotech Customized stable knockdown cell line services for MEOX1 Customized inducible knockdown cell line services for MEOX1 Customized stable overexpressing cell line services for MEOX1 Customized inducible overexpressing cell line services for MEOX1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEOX1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MEOX1

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for MEOX1 (P50221^{2, 3} ENSP00000321684⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PAX1	P15863²^,³, ENSP00000381499⁴	MINT-17255 MINT-17254 I2D: score=5 STRING: ENSP00000381499
PAX3	P23760³, ENSP00000375921⁴	I2D: score=4 STRING: ENSP00000375921
SOX10	P56693³, ENSP00000354130⁴	I2D: score=1 STRING: ENSP00000354130
--	G5E9C1³	I2D: score=1

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001757	somite specification	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0007275	multicellular organismal development	TAS	7987315
GO:0008150	biological_process	ND	--
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA	--

MEOX1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MEOX1

Search CenterWatch for drugs/clinical trials and news about MEOX1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MEOX1 gene (3 alternative transcripts):

NM_001040002.1 NM_004527.3 NM_013999.3

Unigene Cluster for MEOX1:

Mesenchyme homeobox 1

Hs.438 [show with all ESTs]

Unigene Representative Sequence: NM_004527

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000318579(uc002idz.3 uc002iea.3 uc002ieb.3) ENST00000549132

ENST00000393661 ENST00000329168

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEOX1
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate MEOX1 (see all 16):
		hsa-miR-1226 hsa-miR-520d-5p hsa-miR-1285 hsa-miR-3171 hsa-miR-3692 hsa-miR-629* hsa-miR-3658 hsa-miR-24

		SwitchGear 3'UTR luciferase reporter plasmid: MEOX1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against MEOX1

Clone Products:		OriGene clones in human, mouse for MEOX1 (see all 14) OriGene ORF clones in mouse, rat for MEOX1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): MEOX1 (NM_001040002)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEOX1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEOX1

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for MEOX1
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MEOX1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEOX1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEOX1

Additional mRNA sequence:

AK291139.1 BC069474.1 BC069506.1 U10492.1 U10493.1

4 DOTS entries:

DT.86852568 DT.95356559 DT.95356560 DT.95356562

24/65 AceView cDNA sequences (see all 65):

BX284090 NM_004527 NM_013999 BC069506 BC069474 BG677020 AA424161 BQ028272

BF057739 AI185722 AU120742 U10493 AU128418 AW410292 BE898972 BQ003431

AI375755 AI808644 BF307940 AI378323 BF511359 AI707783 U10492 AU131390

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for MEOX1 About this scheme

ExUns:	1	^	2	^	3a	·	3b
SP1:
SP2:			-

ECgene alternative splicing isoforms for MEOX1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MEOX1 expression in normal human tissues (normalized intensities) MEOX1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

MEOX1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/15 selected tissues (see all 15) fully expand


Heart (Cardiovascular System) fully expand to see all 5 entries
Vascular Smooth Muscle Cells Dorsal Aorta
Atrioventricular Canal

Mesoderm (Gastrulation Derivatives) fully expand to see all 4 entries
Mesoderm Cells Mesoderm
Mesoderm
Early mesoderm cells (Generation of human vascular smooth muscle subtypes from human...

Kidney (Urinary System) fully expand to see all 4 entries
Metanephric Mesenchyme Cells Metanephric Mesenchyme
Podocalyxin+, CD24+, GCTM2 (low) (Derivation and sorting of renal cells from human...

Smooth Muscle (Muscoskeletal System) fully expand to see all 3 entries
Vascular Smooth Muscle Cells Dorsal Aorta
Early mesoderm cells (Generation of human vascular smooth muscle subtypes from human...

Head Mesenchyme (Muscoskeletal System) fully expand to see all 2 entries
Cardiac Neural Crest Cells "Branchial Arch 3,4,6"
mandibular prominence tissue e12.5

See MEOX1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MEOX1

SOURCE GeneReport for Unigene cluster: Hs.438

SABiosciences Expression via Pathway-Focused PCR Array including MEOX1:

Homeobox (HOX) Genes in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEOX1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEOX1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MEOX1 gene from 6/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Meox1^{1 , 5}	mesenchyme homeobox 1^{1, 5}	84.13(n)¹ 82.14(a)¹		11 (65.48 cM)⁵ 17285¹ NM_010791.3¹ NP_034921.1¹ 101877510⁵
chicken (Gallus gallus)	Aves	MEOX1¹	mesenchyme homeobox 1	68.47(n) 64.17(a)		395533 NM_204765.1 NP_990096.1
lizard (Anolis carolinensis)	Reptilia	MEOX1⁶	Uncharacterized protein	61(a)	1 ↔ 1	6(78013024-78027695)
zebrafish (Danio rerio)	Actinopterygii	meox1¹	mesenchyme homeobox 1	62.83(n) 57.2(a)		436723 NM_001002450.2 NP_001002450.2
fruit fly (Drosophila melanogaster)	Insecta	btn⁶ CG15696⁶	--	34(a) 16(a)	many → 1 possible ortholog	3R(18411871-18412347) 3R(16672833-16673372)
worm (Caenorhabditis elegans)	Secernentea	ceh-12⁶ ceh-62⁶	Uncharacterized homeobox protein R06F6.6	24(a) 10(a)	possible ortholog possible ortholog	I(5840289-5841888) II(10805394-10809992)

ENSEMBL Gene Tree for MEOX1 (if available)
TreeFam Gene Tree for MEOX1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MEOX1 gene

MNX1² EVX1² GBX1² EVX2² MEOX2² GBX2²

2 SIMAP similar genes for MEOX1 using alignment to 2 protein entries: MEOX1_HUMAN (see all proteins):

POU6F1 MEOX2

MEOX1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112448546^1,2	C	--	37488283(+)	`GAGGAAAAC/- AAATT`	3	--	int¹		1		CSA	2
rs143224431^1,2	C	--	37498734(+)	`TTTCT-/TTTC TTTCT`	3	--	int¹		0	--	--	--	--
rs10712114^1,2	C	--	37505368(+)	`ACTTC-/TTTTTT`	1	--	us2k¹ trp³		1		CSA	2
rs7226183^1,2	C,H	--	37505381(+)	`tttttT/Cctttt`	1	--	us2k¹ trp³		1		NA	2
rs58709943^1,2	C	--	41720055(+)	`ACAAA-/AACA A/ACAAAGGGCC`	3	--	int¹		1		NA	2
rs58390408^1,2	C	--	41720515(+)	`AAAAA-/ACAAAA`	3	--	int¹		1		CSA	2
rs139847579^1,2	C	--	41723980(+)	`TGAGG-/AAA A/ACAAAAATT`	3	--	int¹		0	--	--	--	--
rs72213620^1,2	C	--	41723982(+)	`AGGAA-/AAAC ATTTC`	3	--	int¹		0	--	--	--	--
rs60726674^1,2	C	--	41723983(+)	`GGAAAACAA/- TTTCA`	3	--	int¹		1		NA	2
rs67553599^1,2	C	--	41725851(-)	`TTTTC-/C/TTTTTT`	3	--	int¹		2		NA	4

HapMap Linkage Disequilibrium report for MEOX1 (41717756 - 41739322 bp)

Structural Variations
Database of Genomic Variants (DGV) 5 variations for MEOX1: About this table

Variant ID	Type	Subtype	PubMed ID
esv2715958	CNV	Deletion	23290073
nsv908266	CNV	Loss	21882294
nsv908265	CNV	Gain	21882294
nsv819106	CNV	Gain	19587683
nsv908264	CNV	Gain	21882294

Human Gene Mutation Database (HGMD): MEOX1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEOX1

DNA2.0 Custom Variant and Variant Library Synthesis for MEOX1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MEOX1 for disorders           About GeneDecksing

OMIM gene information: 600147    OMIM disorders: --

4 diseases for MEOX1:    About MalaCards

diaphanospondylodysostosis sost-related sclerosing bone dysplasia klippel-feil syndrome mesoblastic nephroma

3 diseases from the University of Copenhagen DISEASES database for MEOX1:

Klippel-Feil syndrome Mesoblastic nephroma SOST-related sclerosing bone dysplasia

Genetic Association Database (GAD): MEOX1

Export disorders for MEOX1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MEOX1 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with MEOX1)

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Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture. (PubMed id 7987315)^{1, 2, 3, 9} Futreal P.A....Wiseman R.W. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Mutations in MEOX1, encoding mesenchyme homeobox 1, ca use Klippel-Feil anomaly. (PubMed id 23290072)¹ Mohamed J.Y....Alkuraya F.S. (2013)
Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites. (PubMed id 22567123)¹ Thiaville M.M....Wang T.L. (2012)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
Diaphanospondylodysostosis: six new cases and exclusion of the candidate genes, PAX1 and MEOX1. (PubMed id 17764081)¹ Vatanavicharn N....Wilcox W.R. (2007)
The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. (PubMed id 16582099)¹ Wissmuller S....Wegner M. (2006)
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)² Zody M.C.... Nusbaum C. (2006)
Hedgehog signaling induces cardiomyogenesis in P19 cells. (PubMed id 15793308)¹ Gianakopoulos P.J. and Skerjanc I.S. (2005)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4222	HGNC: 7013	AceView: MEOX1	Ensembl:ENSG00000005102	euGenes: HUgn4222
ECgene: MEOX1	H-InvDB: MEOX1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MEOX1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MEOX1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MEOX1 gene
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Patent Information for MEOX1 gene:
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GeneCards and IP:
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MEOX1 Gene

Mesenchyme Homeobox 1

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MEOX1 Gene

Mesenchyme Homeobox 1

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