MEN1 Gene
protein-coding GIFtS: 64
GCID: GC11M064570
|
|
multiple endocrine neoplasia I
| |
Aliases
for MEN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Multiple Endocrine Neoplasia I1 2 | | SCG22 3 | | MEAI2 | | Menin1 |
Export aliases for MEN1 gene to outside databasesPrevious GC identifers: GC11P067708 GC11M066252 GC11M064821 GC11M064346 GC11M064327 GC11M060898 |
Summaries
for MEN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MEN1:
This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasiatype 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localizationsignals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Twomessages have been detected on northern blots but the larger message has not been characterized. Alternative splicingresults in multiple transcript variants. (provided by RefSeq, Oct 2008)
UniProtKB/Swiss-Prot: MEN1_HUMAN, O00255Function: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specificallymethylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter andrepresses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulatingSMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as thatmediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normalhematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair
Gene Wiki entry for MEN1
|
Genomic Views
for MEN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MEN1 gene promoter:
PPAR-gamma1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MEN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13MEN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M064570: view genomic region
(about GC identifiers)
Start:
|
64,570,986 bp from pter |
End:
|
64,578,766 bp from pter |
Size:
|
7,781 bases |
Orientation:
|
minus strand |
|
Proteins
for MEN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MEN1_HUMAN, O00255 (See
protein sequence)Recommended Name: Menin Size: 615 amino acids; 68023 Da
Subunit: Component of the MLL-HCF complex, at least composed of MLL, MEN1, ASH2L, RBBP5, DPY30, WDR5, HCFC1 and HCFC2.Component of the menin-associated histone methyltransferase complex, at least composed of MLL4/WBP7, MEN1, ASH2L,RBBP5, DPY30 and WDR5. Interacts with POLR2B. Interacts with POLR2A phosphorylated at 'Ser-5', but not with theunphosphorylated, nor 'Ser-2' phosphorylated POLR2A forms. Interacts with FANCD2 and DBF4. Interacts with JUND.Interacts with SMAD3, but not with SMAD2, nor SMAD4. Directly interacts with NFKB1, NFKB2 and RELA
Subcellular location: Nucleus. Note=Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upongamma irradiation
Sequence caution: Sequence=ABQ12624.1; Type=Frameshift; Positions=383; Note=The frameshift is caused by a singlenucleotide deletion which is found in a MEN1 kindred; Sequence=ABQ12627.1; Type=Frameshift; Positions=97; Note=Theframeshift is caused by a single nucleotide deletion which is found in a MEN1 kindred;
6/8 PDB 3D structures from  and Proteopedia  for MEN1 (see all 8):3U84 (3D)
3U85 (3D)
3U86 (3D)
3U88 (3D)
4GPQ (3D)
4GQ3 (3D)
Secondary accessions: A5HBC6 A5HBC7 A5HBC8 A5HBC9 A5HBD0 A5HBD1 A5HBD2 O00632 Q9BUF0 Q9BUK2Alternative splicing: 3 isoforms: O00255-1 O00255-2 O00255-3 Explore the universe of human proteins at neXtProt for MEN1: NX_O00255
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00255
MEN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (7 alternative transcripts):
NP_000235.2 NP_570711.1 NP_570712.1 NP_570713.1 NP_570714.1 NP_570715.1 NP_570716.1
ENSEMBL proteins: ENSP00000366533 ENSP00000366538 ENSP00000366543 ENSP00000308975 ENSP00000323747 ENSP00000366530 ENSP00000413944 ENSP00000394933 ENSP00000411218 ENSP00000402752 ENSP00000388016 ENSP00000337088 ENSP00000377901 ENSP00000377899 ENSP00000396940 Reactome Protein details: O00255
Human Recombinant Protein Products:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
MEN1 for ontologies About GeneDecksing
MEN1 Antibody Products:
Assay Products for MEN1: |
Protein
Domains /
Families
for MEN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MEN1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O00255ProtoNet protein and cluster: O00255 |
Function
for MEN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MEN1_HUMAN, O00255Function: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specificallymethylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter andrepresses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulatingSMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as thatmediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normalhematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair Genatlas biochemistry entry for MEN1:menin,nuclear protein of unknown function,ubiquitously expressed,transcriptional repressor through interaction with thetranscription factor JUND by an histone deacetylase dependent mechanism,mutated in multiple endocrine neoplasia1,isolated hyperparathyroid tumor,gastrinoma,insulinoma,bronchial carcinoid
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEN1 (see all 12)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEN1 (see all 7)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 7): MEN1 (NM_130799) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MEN1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEN1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEN1 |
Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12): About this table
MEN1 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for MEN1:
Animal Models:
Mouse knock-outs for MEN1: Men1tm1Rvt Men1tm1.1Ctre Men1tm1.1Zqw Men1tm1.1Gfk Men1tm1Zqw Men1tm1Mmey
Men1tm2.1Gfk
15 MGI mutant phenotypes (inferred from 12 alleles ) (MGI details for Men1):
MEN1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MEN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | | | 2 | Generic Transcription Pathway | | | 3 | Chromatin Regulation / Acetylation | | | 4 | Signaling by GPCR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for MEN1
5/6 
Reactome Pathways for MEN1 (see all 6)
MEN1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MEN1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/75 Interacting proteins for MEN1 (O002551, 2, 3 ENSP000003370884) via UniProtKB, MINT, STRING, and/or I2D (see all 75)About this table
Gene Ontology (GO): 5/45 biological process terms (GO ID links to tree view) (see all 45): About this table
MEN1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MEN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MEN1 for compounds About GeneDecksing
 Browse Tocris compounds for MEN1
9 Novoseek chemical compound relationships for MEN1 gene About this table
Search CenterWatch for drugs/clinical trials and news about MEN1
|
Transcripts
for MEN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MEN1 gene (7 alternative transcripts): NM_000244.3 NM_130799.2 NM_130800.2 NM_130801.2 NM_130802.2 NM_130803.2 NM_130804.2 Unigene Cluster for MEN1: Multiple endocrine neoplasia I Hs.423348 [show with all ESTs]Unigene Representative Sequence: NM_13080317 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000377316 ENST00000377321 ENST00000377326 ENST00000312049(uc001obm.3)
ENST00000315422(uc001obl.3) ENST00000377313 ENST00000478548 ENST00000487019
ENST00000440873 ENST00000450708 ENST00000413626 ENST00000429702 ENST00000424912
ENST00000337652(uc001obr.3) ENST00000394376(uc001obq.3) ENST00000394374(uc001obj.3 uc001obk.3 uc001obo.3)
ENST00000443283(uc001obn.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEN1 (see all 12)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEN1 (see all 7)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 7): MEN1 (NM_130799) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MEN1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEN1 |
Additional cDNA sequence: AJ297485.1 AJ297486.1 AJ297487.1 AJ297488.1 AJ297489.1 BC002544.2 BC002664.2 U93236.1 Y12338.1 14 DOTS entries: DT.97763709 DT.317546 DT.100028453 DT.100655505 DT.100028456 DT.100655496 DT.100028454 DT.91760399 DT.91760392 DT.97846333 DT.40110073 DT.100712842 DT.91760395 DT.95123923 24/277 AceView cDNA sequences (see all 277): AI208562 AW157832 AI056630 AI371103 CF130250 BQ021832 BU730594 N36190 BQ066743 BQ883363 AI367230 AA653176 AI633641 BQ006247 CA450369 AJ297485 AI078460 CB160970 CD515360 BQ954421 AA831698 AW008903 BX393203 CR598705
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for MEN1 (see all 9) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MEN1
|
Expression
for MEN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MEN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MEN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MEN1
SOURCE GeneReport for Unigene cluster: Hs.423348
UniProtKB/Swiss-Prot: MEN1_HUMAN, O00255Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Arrays including MEN1: | Oncogenes & Tumor Suppressor Genes in human mouse rat | | Epigenetic Chromatin Modification Enzymes in human mouse rat | | Telomeres & Telomerase in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEN1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MEN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEN1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEN1 |
Orthologs
for MEN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MEN1 gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for MEN1 (if available)
TreeFam Gene Tree for MEN1 (if available) |
Paralogs
for MEN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MEN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MEN1 (64570986 - 64578766 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MEN1
2 CNVs: 4753 53146
Human Gene Mutation Database (HGMD): MEN1
Locus Specific Mutation Databases (LSDB): MEN1
| 5/14 SABiosciences Cancer Mutation PCR Assays for MEN1 (see all 14): |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEN1 |
|
Disorders
/ Diseases
for MEN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MEN1 for disorders About GeneDecksing
OMIM gene information: 613733
OMIM disorders: 131100
UniProtKB/Swiss-Prot: MEN1_HUMAN, O00255
Defects in MEN1 are the cause of familial multiple endocrine neoplasia type I (MEN1) [MIM:131100]. Autosomaldominant disorder characterized by tumors of the parathyroid glands, gastro-intestinal endocrine tissue, the anteriorpituitary and other tissues. Cutaneous lesions and nervous-tissue tumors can exist. Prognosis in MEN1 patients isrelated to hormonal hypersecretion by tumors, such as hypergastrinemia causing severe peptic ulcer disease(Zollinger-Ellison syndrome, ZES), primary hyperparathyroidism, and acute forms of hyperinsulinemia Defects in MEN1 are the cause of familial isolated hyperparathyroidism (FIHP) [MIM:145000]; also known ashyperparathyroidism type 1 (HRPT1). FIHP is an autosomal dominant disorder characterized by hypercalcemia, elevatedparathyroid hormone (PTH) levels, and uniglandular or multiglandular parathyroid tumors
20/105  diseases for MEN1 (see all 105): About MalaCardsmultiple endocrine neoplasia von hippel-lindau disease zollinger-ellison syndrome growth hormone secreting pituitary adenoma
parathyroid adenoma, somatic adrenal adenoma, somatic parathyroid adenoma islet cell tumor
end stage renal failure angiofibroma, somatic lipoma, somatic adrenal adenoma
mccune albright syndrome familial isolated hyperparathyroidism angiofibroma parathyroid gland disease
lipoma hyperinsulinemic hypoglycemia pancreatic islet cell tumors pituitary adenoma
14 diseases from the University of Copenhagen DISEASES database for MEN1:Wermer syndrome Hyperparathyroidism Gastrinoma Adenoma
Carney complex Pituitary adenoma Pancreatic cancer Parathyroid adenoma
Acromegaly Parathyroid carcinoma VIPoma Hypercalcemia
Hemangioma McCune Albright syndrome 10/78 Novoseek disease relationships for MEN1 gene (see all 78) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| multiple endocrine neoplasia type 1 |
97.9 |
190 |
10664520 (3), 10849016 (3), 10993647 (3), 10709111 (2) (see all 99) |
| multiple endocrine neoplasia |
90 |
17 |
11167122 (1), 11901838 (1), 16449969 (1), 10565680 (1) (see all 17) |
| hrpt2 |
85.4 |
18 |
19474519 (4), 17065424 (3), 16430712 (3), 17338170 (2) (see all 9) |
| gastrinoma |
85.3 |
11 |
15944766 (2), 10548885 (2), 12915685 (1), 17961653 (1) (see all 7) |
| hyperparathyroidism |
84.8 |
59 |
15635078 (3), 11966738 (3), 9843042 (2), 14633735 (2) (see all 33) |
| hyperparathyroidism primary |
84 |
18 |
15292357 (2), 10870030 (2), 20058152 (1), 12016470 (1) (see all 15) |
| parathyroid adenoma |
83.5 |
28 |
10963041 (3), 15168774 (2), 8803711 (2), 10548885 (2) (see all 16) |
| pituitary tumors |
80.2 |
21 |
9543172 (2), 20175454 (1), 19564887 (1), 10424779 (1) (see all 17) |
| parathyroid hyperplasia |
79.1 |
5 |
10993646 (1), 9598800 (1), 10915003 (1), 15870131 (1) (see all 5) |
| pituitary adenoma |
78 |
29 |
11836268 (4), 10424779 (3), 15163308 (2), 15704128 (2) (see all 14) |
Genatlas disease: MEN1 endocrine neoplasia,multiple,type 1,hyperparathyroidism,gastrinoma,somatotrophinoma,prolactinoma,Wermer syndrome (MEN1defect),including somatic mutations in sporadic neuroendocrine and pancreatic tumors,and carcinoid tumors of lungs andin fore foregut neoplasms,excluding the sporadic hyperplastic or neoplastic lesions of the adrenal cortex
GeneTests: MEN1
Multiple Endocrine Neoplasia Type 1
Genetic Association Database (GAD): MEN1
Human Genome Epidemiology (HuGE) Navigator: MEN1 (29 documents)
Export disorders for MEN1 gene to outside databases
|
Publications
for MEN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MEN1 gene, integrated from 9 sources (see all 489):
(articles sorted by number of sources associating them with MEN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Pituitary disease in MEN type 1 (MEN1): data from the France-Belgium MEN1 multicenter study. (PubMed id 11836268)1, 4, 9 Verges B....Calender A. (2002)
- Somatic mutation of the MEN1 gene in parathyroid tumours. (PubMed id 9241276)1, 2, 9 Heppner C.... Marx S.J. (1997)
- Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states. (PubMed id 9215689)1, 2, 9 Agarwal S.K.... Marx S.J. (1997)
- Menin associates with FANCD2, a protein involved in repair of DNA damage. (PubMed id 12874027)1, 2, 9 Jin S....Hua X. (2003)
- Functional interaction between tumor suppressor menin and activator of S-phase kinase. (PubMed id 15374998)1, 2, 9 Schnepp R.W....Hua X. (2004)
- Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling. (PubMed id 11274402)1, 2, 9 Kaji H....Hendy G.N. (2001)
- Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. (PubMed id 15199122)1, 2, 9 Yokoyama A.... Cleary M.L. (2004)
- The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation. (PubMed id 11526476)1, 2, 9 Heppner C....Burns A.L. (2001)
- Pituitary macroadenoma in a 5-year-old: an early expression of multiple endocrine neoplasia type 1. (PubMed id 11134142)1, 2, 9 Stratakis C.A....Marx S.J. (2000)
- Germline mutations in the MEN1 gene: creation of a new splice acceptor site and insertion of 7 intron nucleotides into the mRNA. (PubMed id 10534569)1, 2, 9 Engelbach M....Beyer J. (1999)
|
External Searches for MEN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MEN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MEN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MEN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MEN1 | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for MEN1 | Genetics and Cytogenetics in Oncology and Haematology | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MEN1 |
|
| | |
About This Section
| Patent Information for MEN1 gene:
Search GeneIP for patents involving MEN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MEN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for MEN1 | | OriGene shRNA RFP for MEN1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEN1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEN1 | | | OriGene Protein Over-expression Lysate for MEN1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MEN1 | | OriGene 3'-UTR Clone for MEN1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEN1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEN1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MEN1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MEN1 | | OriGene Custom Protein Services for MEN1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MEN1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEN1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEN1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEN1 |
| |
 |  |  |  | |
| | Antibodies & Assays for MEN1 |
| | | | Search Tocris compounds for MEN1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | MEN1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEN1 |
|  |  |  | | | | ThermoFisher Antibodies for MEN1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEN1 |
|
|
|
|
