Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MEMO1 Gene

Aliases for MEMO1 Gene

  • Mediator Of Cell Motility 1 2 3 4 5
  • Hepatitis C Virus NS5A-Transactivated Protein 7 3 4
  • Mediator Of ErbB2-Driven Cell Motility 1 3 4
  • HCV NS5A-Transactivated Protein 7 3 4
  • C21orf19-Like Protein 3 4
  • NS5ATP7 3 4
  • C2orf4 3 4
  • MEMO 3 4
  • Chromosome 2 Open Reading Frame 4 2
  • Protein MEMO1 3
  • CGI-27 3
  • Memo-1 4

External Ids for MEMO1 Gene

Previous HGNC Symbols for MEMO1 Gene

  • C2orf4

Previous GeneCards Identifiers for MEMO1 Gene

  • GC01U990194
  • GC02M031946
  • GC02M032092

Summaries for MEMO1 Gene

GeneCards Summary for MEMO1 Gene

MEMO1 (Mediator Of Cell Motility 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by ERBB2.

UniProtKB/Swiss-Prot for MEMO1 Gene

  • May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEMO1 Gene

Genomics for MEMO1 Gene

Regulatory Elements for MEMO1 Gene

Enhancers for MEMO1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F031987 0.9 Ensembl ENCODE 11.9 +23.4 23430 1.6 CTCF SOX13 JUN CEBPG ZNF366 NR2F6 HOMEZ THAP11 GATAD2A SOX5 SLC30A6 MEMO1 DPY30 GC02P031938
GH02F031888 0.6 Ensembl 11.6 +122.7 122730 0.6 ATF3 ZNF175 CEBPB PRDM1 MEMO1 DPY30 GC02P031895 ENSG00000273165
GH02F031893 0.9 Ensembl 11.6 +117.9 117930 0.2 CEBPB MEMO1 DPY30 GC02P031895 ENSG00000273165
GH02F031894 0.2 Ensembl 11.6 +117.1 117130 1.0 ZSCAN29 MEMO1 DPY30 GC02P031895 ENSG00000273165
GH02F031966 0.2 ENCODE 11.2 +44.6 44644 0.2 ZNF121 IKZF1 HMBOX1 MEMO1 DPY30 GC02P031938
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MEMO1 on UCSC Golden Path with GeneCards custom track

Promoters for MEMO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000587703 1130 3401 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1

Genomic Location for MEMO1 Gene

Chromosome:
2
Start:
31,865,060 bp from pter
End:
32,011,230 bp from pter
Size:
146,171 bases
Orientation:
Minus strand

Genomic View for MEMO1 Gene

Genes around MEMO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEMO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEMO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEMO1 Gene

Proteins for MEMO1 Gene

  • Protein details for MEMO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y316-MEMO1_HUMAN
    Recommended name:
    Protein MEMO1
    Protein Accession:
    Q9Y316
    Secondary Accessions:
    • B4DLS0
    • D6W575
    • Q5R2V8
    • Q5R2V9
    • Q6NSL5

    Protein attributes for MEMO1 Gene

    Size:
    297 amino acids
    Molecular mass:
    33733 Da
    Quaternary structure:
    • Interacts with ERBB2 phosphorylated on Tyr-1248.

    Three dimensional structures from OCA and Proteopedia for MEMO1 Gene

    Alternative splice isoforms for MEMO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEMO1 Gene

Post-translational modifications for MEMO1 Gene

  • Ubiquitination at Lys 115
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MEMO1 Gene

Domains & Families for MEMO1 Gene

Protein Domains for MEMO1 Gene

Suggested Antigen Peptide Sequences for MEMO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y316

UniProtKB/Swiss-Prot:

MEMO1_HUMAN :
  • Belongs to the MEMO1 family.
Family:
  • Belongs to the MEMO1 family.
genes like me logo Genes that share domains with MEMO1: view

No data available for Gene Families for MEMO1 Gene

Function for MEMO1 Gene

Molecular function for MEMO1 Gene

GENATLAS Biochemistry:
modifier of methylation for class I HLA genes,often deleted in neuroblastoma
UniProtKB/Swiss-Prot Function:
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.

Gene Ontology (GO) - Molecular Function for MEMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with MEMO1: view
genes like me logo Genes that share phenotypes with MEMO1: view

Animal Models for MEMO1 Gene

MGI Knock Outs for MEMO1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEMO1 Gene

Localization for MEMO1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEMO1 Gene COMPARTMENTS Subcellular localization image for MEMO1 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MEMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16780588
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MEMO1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MEMO1 Gene

Pathways & Interactions for MEMO1 Gene

genes like me logo Genes that share pathways with MEMO1: view

Pathways by source for MEMO1 Gene

Gene Ontology (GO) - Biological Process for MEMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032886 regulation of microtubule-based process IMP 20937854
GO:2000145 regulation of cell motility TAS --
genes like me logo Genes that share ontologies with MEMO1: view

No data available for SIGNOR curated interactions for MEMO1 Gene

Transcripts for MEMO1 Gene

Unigene Clusters for MEMO1 Gene

Mediator of cell motility 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEMO1 Gene

No ASD Table

Relevant External Links for MEMO1 Gene

GeneLoc Exon Structure for
MEMO1
ECgene alternative splicing isoforms for
MEMO1

Expression for MEMO1 Gene

mRNA expression in normal human tissues for MEMO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MEMO1 Gene

This gene is overexpressed in Lymph node (7.2) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MEMO1 Gene



Protein tissue co-expression partners for MEMO1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MEMO1 Gene:

MEMO1

SOURCE GeneReport for Unigene cluster for MEMO1 Gene:

Hs.444969
genes like me logo Genes that share expression patterns with MEMO1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MEMO1 Gene

Orthologs for MEMO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MEMO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEMO1 34
  • 99.89 (n)
dog
(Canis familiaris)
Mammalia MEMO1 34 35
  • 98.19 (n)
cow
(Bos Taurus)
Mammalia MEMO1 34 35
  • 97.2 (n)
mouse
(Mus musculus)
Mammalia Memo1 34 16 35
  • 96.07 (n)
rat
(Rattus norvegicus)
Mammalia Memo1 34
  • 96.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MEMO1 35
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MEMO1 35
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves MEMO1 34 35
  • 90.12 (n)
lizard
(Anolis carolinensis)
Reptilia MEMO1 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia memo1 34
  • 81.82 (n)
Str.10150 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24007 34
zebrafish
(Danio rerio)
Actinopterygii memo1 34 35
  • 76.54 (n)
wufi04d12 34
fruit fly
(Drosophila melanogaster)
Insecta CG8031 34 35
  • 61.46 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010011 34
  • 58.07 (n)
worm
(Caenorhabditis elegans)
Secernentea tag-253 34 35
  • 54.17 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MHO1 34 37
  • 48.83 (n)
-- 35
  • 35 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A11836g 34
  • 47.55 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR321W 34
  • 45.15 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G25280 34
  • 55.52 (n)
rice
(Oryza sativa)
Liliopsida Os08g0299000 34
  • 55.99 (n)
Os.8918 34
barley
(Hordeum vulgare)
Liliopsida Hv.792 34
wheat
(Triticum aestivum)
Liliopsida Ta.8110 34
corn
(Zea mays)
Liliopsida Zm.10697 34
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC4H3.04c 34
  • 49.05 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU11386 34
  • 48.12 (n)
Species where no ortholog for MEMO1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MEMO1 Gene

ENSEMBL:
Gene Tree for MEMO1 (if available)
TreeFam:
Gene Tree for MEMO1 (if available)

Paralogs for MEMO1 Gene

genes like me logo Genes that share paralogs with MEMO1: view

No data available for Paralogs for MEMO1 Gene

Variants for MEMO1 Gene

Sequence variations from dbSNP and Humsavar for MEMO1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1005460 -- 31,940,505(+) AAAAC(A/T)TAAGA intron-variant
rs1011309 -- 31,954,463(+) ttttt(A/T)aaaaa intron-variant
rs10153837 -- 31,920,345(+) TTCTT(C/T)CAGAG intron-variant
rs10153899 -- 31,922,898(+) attcc(A/T)tgtct intron-variant
rs10169149 -- 31,880,396(+) AGCAA(A/C)TAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEMO1 Gene

Variant ID Type Subtype PubMed ID
esv2659847 CNV deletion 23128226
esv2719875 CNV deletion 23290073
esv3351835 CNV insertion 20981092
esv3590232 CNV loss 21293372
esv3590233 CNV loss 21293372
esv3590235 CNV loss 21293372
nsv1123308 CNV deletion 24896259
nsv1134847 CNV deletion 24896259
nsv508718 CNV deletion 20534489
nsv963219 CNV duplication 23825009

Variation tolerance for MEMO1 Gene

Residual Variation Intolerance Score: 36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEMO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEMO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEMO1 Gene

Disorders for MEMO1 Gene

Relevant External Links for MEMO1

Genetic Association Database (GAD)
MEMO1
Human Genome Epidemiology (HuGE) Navigator
MEMO1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEMO1

No disorders were found for MEMO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEMO1 Gene

Publications for MEMO1 Gene

  1. Memo mediates ErbB2-driven cell motility. (PMID: 15156151) Marone R. … Badache A. (Nat. Cell Biol. 2004) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. (PMID: 20937854) Zaoui K. … Badache A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4 64
  4. Memo is homologous to nonheme iron dioxygenases and binds an ErbB2- derived phosphopeptide in its vestigial active site. (PMID: 18045866) Qiu C. … Leahy D.J. (J. Biol. Chem. 2008) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for MEMO1 Gene

Sources for MEMO1 Gene

Content
Loading form....