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MEMO1 Gene

protein-coding   GIFtS: 51
GCID: GC02M032092

Mediator Of Cell Motility 1

(Previous name: chromosome 2 open reading frame 4)
(Previous symbol: C2orf4)
  See MEMO1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mediator Of Cell Motility 11 2 3     C21orf19-Like Protein2 3
C2orf41 2 3 5     HCV NS5A-Transactivated Protein 72 3
MEMO2 3 5     Chromosome 2 Open Reading Frame 41
Hepatitis C Virus NS5A-Transactivated Protein 72 3     memo-12
Mediator Of ErbB2-Driven Cell Motility 12 3     Protein MEMO12
NS5ATP72 3     Memo-13

External Ids:    HGNC: 140141   Entrez Gene: 510722   Ensembl: ENSG000001629597   OMIM: 6117865   UniProtKB: Q9Y3163   

Export aliases for MEMO1 gene to outside databases

Previous GC identifers: GC01U990194 GC02M031946


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MEMO1 Gene:
MEMO1 (mediator of cell motility 1) is a protein-coding gene. Diseases associated with MEMO1 include hepatitis c, and hepatitis c virus.

UniProtKB/Swiss-Prot: MEMO1_HUMAN, Q9Y316
Function: May control cell migration by relaying extracellular chemotactic signals to the microtubule
cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in
ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2
to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization
of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for
breast carcinoma cell migration




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MEMO1 gene promoter:
         GR   AP-2gamma   NF-kappaB   Arnt   C/EBPalpha   E2F-1   E2F   HSF1short   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMEMO1 promoter sequence
   Search Chromatin IP Primers for MEMO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEMO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22-p21   Ensembl cytogenetic band:  2p22.3   HGNC cytogenetic band: 2p22-p21

MEMO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEMO1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M032092:  view genomic region     (about GC identifiers)

Start:
32,090,129 bp from pter      End:
32,236,299 bp from pter
Size:
146,171 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MEMO1_HUMAN, Q9Y316 (See protein sequence)
Recommended Name: Protein MEMO1  
Size: 297 amino acids; 33733 Da
Subunit: Interacts with ERBB2 phosphorylated on 'Tyr-1248'
2 PDB 3D structures from and Proteopedia for MEMO1:
3BCZ (3D)        3BD0 (3D)    
Secondary accessions: B4DLS0 D6W575 Q5R2V8 Q5R2V9 Q6NSL5
Alternative splicing: 3 isoforms:  Q9Y316-1   Q9Y316-2   Q9Y316-3   

Explore the universe of human proteins at neXtProt for MEMO1: NX_Q9Y316

Explore proteomics data for MEMO1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys115
  • Modification sites at PhosphoSitePlus

  • See MEMO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001131074.1  NP_057039.1  

    ENSEMBL proteins: 
     ENSP00000295065   ENSP00000368691   ENSP00000385557   ENSP00000400795   ENSP00000385321  
     ENSP00000409621  

    MEMO1 Human Recombinant Protein Products:

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    Novus Biologicals MEMO1 Protein
    Novus Biologicals MEMO1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MEMO1
    Cloud-Clone Corp. Proteins for MEMO1

     
    Search eBioscience for Proteins for MEMO1 

    MEMO1 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for MEMO1

    MEMO1 Assay Products:

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    Cloud-Clone Corp. ELISAs for MEMO1
    Cloud-Clone Corp. CLIAs for MEMO1
    Search eBioscience for ELISAs for MEMO1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002737 MEMO1_fam

    Graphical View of Domain Structure for InterPro Entry Q9Y316

    ProtoNet protein and cluster: Q9Y316

    1 Blocks protein domain: IPB002737 Protein of unknown function DUF52

    UniProtKB/Swiss-Prot: MEMO1_HUMAN, Q9Y316
    Similarity: Belongs to the MEMO1 family


    Find genes that share domains with MEMO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MEMO1_HUMAN, Q9Y316
    Function: May control cell migration by relaying extracellular chemotactic signals to the microtubule
    cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in
    ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2
    to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization
    of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for
    breast carcinoma cell migration

         Genatlas biochemistry entry for MEMO1:
    modifier of methylation for class I HLA genes,often deleted in neuroblastoma

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with MEMO1           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Memo1 (no phenotypes)

    Find genes that share phenotypes with MEMO1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MEMO1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MEMO1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MEMO1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MEMO1

    miRNA
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    Block miRNA regulation of human, mouse, rat MEMO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MEMO1 (see all 42):
    hsa-miR-219-1-3p hsa-miR-26a-2* hsa-miR-3194-5p hsa-let-7a-2* hsa-miR-301a hsa-miR-346 hsa-miR-374c hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidMEMO1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat MEMO1

    Gene Editing
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    GenScript Custom all cDNA clones Services for MEMO1
    Sino Biological Human cDNA Clone for MEMO1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEMO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEMO1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEMO1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16780588
    GO:0005829cytosol IDA16780588

    Find genes that share ontologies with MEMO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MEMO1
    Interactions:

        Search GeneGlobe Interaction Network for MEMO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for MEMO1 (Q9Y3161, 2, 3 ENSP000002950654) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046261, 2, 3, ENSP000002695714EBI-1104564,EBI-641062 MINT-8202763 MINT-8202727 MINT-8202780 MINT-8202797 MINT-8202814 MINT-8202835 I2D: score=1 STRING: ENSP00000269571
    ENSG00000096150P622693I2D: score=2 
    ENSG00000223367P622693I2D: score=2 
    ENSG00000226225P622693I2D: score=2 
    ENSG00000235650P622693I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032886regulation of microtubule-based process IMP--

    Find genes that share ontologies with MEMO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MEMO1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MEMO1 gene (2 alternative transcripts): 
    NM_001137602.1  NM_015955.2  

    Unigene Cluster for MEMO1:

    Mediator of cell motility 1
    Hs.444969  [show with all ESTs]
    Unigene Representative Sequence: AK022169
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295065(uc002rnx.3 uc010ymu.2) ENST00000379383 ENST00000404530(uc010ezq.3)
    ENST00000490459(uc002rny.3) ENST00000426310 ENST00000422936 ENST00000413686
    ENST00000407893 ENST00000437854
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MEMO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MEMO1 (see all 42):
    hsa-miR-219-1-3p hsa-miR-26a-2* hsa-miR-3194-5p hsa-let-7a-2* hsa-miR-301a hsa-miR-346 hsa-miR-374c hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidMEMO1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MEMO1
    Predesigned siRNA for gene silencing in human, mouse, rat MEMO1
    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEMO1
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MEMO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MEMO1
      QuantiTect SYBR Green Assays in human, mouse, rat MEMO1
      QuantiFast Probe-based Assays in human, mouse, rat MEMO1

    Additional mRNA sequence: 

    AB041018.1 AB041019.1 AF132961.1 AF363446.1 AF529368.1 AK022169.1 AK057760.1 AK290753.1 
    AK295755.1 AK297128.1 AL161966.1 BC018733.1 BC036262.1 BC070046.1 BC094681.1 

    14 DOTS entries:

    DT.415853  DT.100757941  DT.100784098  DT.95364988  DT.120965234  DT.100675933  DT.120965174  DT.40109407 
    DT.120965260  DT.100744030  DT.120965236  DT.120965267  DT.100784099  DT.100784100 

    Selected AceView cDNA sequences (see all 318):

    AI268698 BM754476 AI539186 BG576844 BU628425 CA776384 CD366686 AA610033 
    CB139619 CB150982 BQ021273 BM475171 CA437525 AK022169 BG114369 CA414392 
    AA569753 AI690126 AA634337 BM909697 CR614281 CB134761 BM772730 AI015531 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MEMO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTACAACA
    MEMO1 Expression
    About this image


    MEMO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    MEMO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MEMO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444969
        Custom PCR Arrays for MEMO1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEMO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MEMO1 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Memo11 , 5 mediator of cell motility 11, 5 96.07(n)1
    99.33(a)1
      17 (45.63 cM)5
    768901  NM_133771.21  NP_598532.11 
     742007005 
    chicken
    (Gallus gallus)
    Aves MEMO11 mediator of cell motility 1 90.12(n)
    97.64(a)
      421483  NM_001195423.1  NP_001182352.1 
    lizard
    (Anolis carolinensis)
    Reptilia MEMO16
    mediator of cell motility 1
    97(a)
    1 ↔ 1
    1(235500964-235518319)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.240072 Xenopus laevis transcribed sequence with weak similarity more 81.75(n)    CA971686.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi04d122 wufi04d12 78.31(n)   327360  BC044360.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG80311 CG8031 61.46(n)
    64.93(a)
      41601  NM_141995.4  NP_650252.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tag-2531 tag-253 54.17(n)
    53.12(a)
      179163  NM_171486.5  NP_741570.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YJR008W)4
    MHO11
    Putative protein of unknown function; expression repressed more4
    MHO11
    48.83(n)1
    44.06(a)1
      10(452430-453446)4
    8534641, 4  NP_012541.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G252801 AT2G25280 55.52(n)
    50.53(a)
      817066  NM_128085.3  NP_565590.1 
    rice
    (Oryza sativa)
    Liliopsida Os.89182 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.56(n)    AK061379.1 


    ENSEMBL Gene Tree for MEMO1 (if available)
    TreeFam Gene Tree for MEMO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MEMO1 gene

    Find genes that share paralogs with MEMO1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for MEMO1 (see all 6)
    PGOHUM00000248664 PGOHUM00000238158 PGOHUM00000238258 PGOHUM00000243364 PGOHUM00000243785


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MEMO1 (see all 2515)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11562641,2
    H--32092401(+) CATAAG/AAAAAT 2 -- int15Minor allele frequency- A:0.00MN NS EA 602
    rs1896696391,2
    C--32092629(+) TATATA/GTTCTG 2 -- int10--------
    rs1814591031,2
    --32092774(+) ATACAA/TCCTAA 2 -- int10--------
    rs1869304441,2
    --32093239(+) CCTAAA/TCTATA 2 -- ut310--------
    rs1907831521,2
    --32093262(+) ATGAGG/TTGAAA 2 -- ut310--------
    rs1444667441,2
    C--32093382(+) ACCCCA/GGACAG 2 -- ut310--------
    rs2017737021,2
    C--32093440(+) GGACCA/GTGAGT 4 T M mis10--------
    rs37696151,2
    C,H--32093535(-) AATGGA/CATGAA 4 G syn12Minor allele frequency- C:0.01NS NA 172
    rs776973951,2
    C--32093573(+) AAAAGA/GAAAAT 2 -- int10--------
    rs1818686781,2
    --32093673(+) CTCTTC/TTGCTC 2 -- int10--------

    HapMap Linkage Disequilibrium report for MEMO1 (32090129 - 32236299 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MEMO1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719875CNV Deletion23290073
    esv2659847CNV Deletion23128226
    nsv873777CNV Loss21882294
    nsv508718CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MEMO1
    DNA2.0 Custom Variant and Variant Library Synthesis for MEMO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611786    OMIM disorders: --

    3 diseases for MEMO1:    
    About MalaCards
    hepatitis c    hepatitis c virus    hepatitis


    Find genes that share disorders with MEMO1           About GenesLikeMe

    Genetic Association Database (GAD): MEMO1
    Human Genome Epidemiology (HuGE) Navigator: MEMO1 (2 documents)

    Export disorders for MEMO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MEMO1 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with MEMO1)
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    1. Memo mediates ErbB2-driven cell motility. (PubMed id 15156151)1, 2, 3 Marone R.... Badache A. (Nat. Cell Biol. 2004)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Memo is homologous to nonheme iron dioxygenases and binds an ErbB2- derived phosphopeptide in its vestigial active site. (PubMed id 18045866)1, 2 Qiu C.... Leahy D.J. (J. Biol. Chem. 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PubMed id 11707072)1, 2 Reymond A....Antonarakis S.E. (Genomics 2001)
    7. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    8. Mediator of ERBB2-driven cell motility (MEMO) promotes extranuclear estrogen receptor signaling involving the growth factor receptors IGF1R and ERBB2. (PubMed id 23861392)1 Jiang K....Ye Q. (J. Biol. Chem. 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. MEMO1, a new IRS1-interacting protein, induces epithelial-mesenchymal transition in mammary epithelial cells. (PubMed id 22824790)1 Sorokin A.V. and Chen J. (Oncogene 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51072 HGNC: 14014 AceView: C2orf4 Ensembl:ENSG00000162959 euGenes: HUgn51072
    ECgene: MEMO1 H-InvDB: MEMO1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MEMO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MEMO1 gene:
    Search GeneIP for patents involving MEMO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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