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Aliases for MEMO1 Gene

Aliases for MEMO1 Gene

  • Mediator Of Cell Motility 1 2 3 4
  • Hepatitis C Virus NS5A-Transactivated Protein 7 3 4
  • Mediator Of ErbB2-Driven Cell Motility 1 3 4
  • HCV NS5A-Transactivated Protein 7 3 4
  • C21orf19-Like Protein 3 4
  • NS5ATP7 3 4
  • C2orf4 3 4
  • MEMO 3 4
  • Chromosome 2 Open Reading Frame 4 2
  • CGI-27 3
  • Memo-1 4

External Ids for MEMO1 Gene

Previous HGNC Symbols for MEMO1 Gene

  • C2orf4

Previous GeneCards Identifiers for MEMO1 Gene

  • GC01U990194
  • GC02M031946
  • GC02M032092

Summaries for MEMO1 Gene

GeneCards Summary for MEMO1 Gene

MEMO1 (Mediator Of Cell Motility 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MEMO1 Gene

  • May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEMO1 Gene

Genomics for MEMO1 Gene

Regulatory Elements for MEMO1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MEMO1 Gene

Chromosome:
2
Start:
31,865,060 bp from pter
End:
32,011,230 bp from pter
Size:
146,171 bases
Orientation:
Minus strand

Genomic View for MEMO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEMO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEMO1 Gene

Proteins for MEMO1 Gene

  • Protein details for MEMO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y316-MEMO1_HUMAN
    Recommended name:
    Protein MEMO1
    Protein Accession:
    Q9Y316
    Secondary Accessions:
    • B4DLS0
    • D6W575
    • Q5R2V8
    • Q5R2V9
    • Q6NSL5

    Protein attributes for MEMO1 Gene

    Size:
    297 amino acids
    Molecular mass:
    33733 Da
    Quaternary structure:
    • Interacts with ERBB2 phosphorylated on Tyr-1248.

    Three dimensional structures from OCA and Proteopedia for MEMO1 Gene

    Alternative splice isoforms for MEMO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEMO1 Gene

Proteomics data for MEMO1 Gene at MOPED

Post-translational modifications for MEMO1 Gene

  • Ubiquitination at Lys 115
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for MEMO1 Gene

Domains & Families for MEMO1 Gene

Protein Domains for MEMO1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MEMO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y316

UniProtKB/Swiss-Prot:

MEMO1_HUMAN :
  • Belongs to the MEMO1 family.
Family:
  • Belongs to the MEMO1 family.
genes like me logo Genes that share domains with MEMO1: view

No data available for Gene Families for MEMO1 Gene

Function for MEMO1 Gene

Molecular function for MEMO1 Gene

GENATLAS Biochemistry:
modifier of methylation for class I HLA genes,often deleted in neuroblastoma
UniProtKB/Swiss-Prot Function:
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.

Gene Ontology (GO) - Molecular Function for MEMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with MEMO1: view
genes like me logo Genes that share phenotypes with MEMO1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEMO1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MEMO1 Gene

Localization for MEMO1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEMO1 Gene COMPARTMENTS Subcellular localization image for MEMO1 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for MEMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16780588
GO:0005829 cytosol IDA 16780588
genes like me logo Genes that share ontologies with MEMO1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MEMO1 Gene

Pathways & Interactions for MEMO1 Gene

SuperPathways for MEMO1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032886 regulation of microtubule-based process IMP 20937854
genes like me logo Genes that share ontologies with MEMO1: view

No data available for Pathways by source and SIGNOR curated interactions for MEMO1 Gene

Drugs & Compounds for MEMO1 Gene

No Compound Related Data Available

Transcripts for MEMO1 Gene

Unigene Clusters for MEMO1 Gene

Mediator of cell motility 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEMO1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEMO1 Gene

No ASD Table

Relevant External Links for MEMO1 Gene

GeneLoc Exon Structure for
MEMO1
ECgene alternative splicing isoforms for
MEMO1

Expression for MEMO1 Gene

mRNA expression in normal human tissues for MEMO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MEMO1 Gene

This gene is overexpressed in Lymph node (7.2) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MEMO1 Gene



SOURCE GeneReport for Unigene cluster for MEMO1 Gene Hs.444969

genes like me logo Genes that share expression patterns with MEMO1: view

Protein tissue co-expression partners for MEMO1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MEMO1 Gene

Orthologs for MEMO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MEMO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MEMO1 35
  • 97.2 (n)
  • 98.54 (a)
MEMO1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEMO1 35
  • 98.19 (n)
  • 100 (a)
MEMO1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Memo1 35
  • 96.07 (n)
  • 99.33 (a)
Memo1 16
Memo1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MEMO1 35
  • 99.89 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Memo1 35
  • 96.07 (n)
  • 99.33 (a)
oppossum
(Monodelphis domestica)
Mammalia MEMO1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEMO1 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves MEMO1 35
  • 90.12 (n)
  • 97.64 (a)
MEMO1 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEMO1 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia memo1 35
  • 81.82 (n)
  • 90.24 (a)
Str.10150 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24007 35
zebrafish
(Danio rerio)
Actinopterygii memo1 35
  • 76.54 (n)
  • 88.22 (a)
wufi04d12 35
memo1 36
  • 89 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010011 35
  • 58.07 (n)
  • 63.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8031 35
  • 61.46 (n)
  • 64.93 (a)
CG8031 36
  • 63 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tag-253 35
  • 54.17 (n)
  • 53.12 (a)
tag-253 36
  • 44 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR321W 35
  • 45.15 (n)
  • 40.78 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A11836g 35
  • 47.55 (n)
  • 44.09 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MHO1 35
  • 48.83 (n)
  • 44.06 (a)
-- 36
  • 35 (a)
OneToOne
-- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G25280 35
  • 55.52 (n)
  • 50.53 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.792 35
rice
(Oryza sativa)
Liliopsida Os.8918 35
Os08g0299000 35
  • 55.99 (n)
  • 53.17 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.8110 35
corn
(Zea mays)
Liliopsida Zm.10697 35
bread mold
(Neurospora crassa)
Ascomycetes NCU11386 35
  • 48.12 (n)
  • 44.37 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC4H3.04c 35
  • 49.05 (n)
  • 42.55 (a)
Species with no ortholog for MEMO1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MEMO1 Gene

ENSEMBL:
Gene Tree for MEMO1 (if available)
TreeFam:
Gene Tree for MEMO1 (if available)

Paralogs for MEMO1 Gene

genes like me logo Genes that share paralogs with MEMO1: view

No data available for Paralogs for MEMO1 Gene

Variants for MEMO1 Gene

Sequence variations from dbSNP and Humsavar for MEMO1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs160795 -- 31,895,003(-) TTTGT(A/G)GGGTT intron-variant
rs160796 -- 31,911,250(-) ttaac(A/G)acata intron-variant
rs160797 -- 31,910,888(-) ctaat(G/T)tacaa intron-variant
rs160798 -- 31,907,502(-) AGTTA(C/T)GTTTT intron-variant
rs160799 -- 31,906,932(-) AAAAA(A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEMO1 Gene

Variant ID Type Subtype PubMed ID
nsv873777 CNV Loss 21882294
nsv508718 CNV Loss 20534489
esv2719875 CNV Deletion 23290073
esv2659847 CNV Deletion 23128226

Variation tolerance for MEMO1 Gene

Residual Variation Intolerance Score: 36.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEMO1 Gene

HapMap Linkage Disequilibrium report
MEMO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEMO1 Gene

Disorders for MEMO1 Gene

Relevant External Links for MEMO1

Genetic Association Database (GAD)
MEMO1
Human Genome Epidemiology (HuGE) Navigator
MEMO1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEMO1
genes like me logo Genes that share disorders with MEMO1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEMO1 Gene

Publications for MEMO1 Gene

  1. Memo mediates ErbB2-driven cell motility. (PMID: 15156151) Marone R. … Badache A. (Nat. Cell Biol. 2004) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for MEMO1 Gene

Sources for MEMO1 Gene

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