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Aliases for MEMO1 Gene

Aliases for MEMO1 Gene

  • Mediator Of Cell Motility 1 2 3 4 5
  • Hepatitis C Virus NS5A-Transactivated Protein 7 3 4
  • Mediator Of ErbB2-Driven Cell Motility 1 3 4
  • HCV NS5A-Transactivated Protein 7 3 4
  • C21orf19-Like Protein 3 4
  • NS5ATP7 3 4
  • C2orf4 3 4
  • MEMO 3 4
  • Chromosome 2 Open Reading Frame 4 2
  • Protein MEMO1 3
  • CGI-27 3
  • Memo-1 4

External Ids for MEMO1 Gene

Previous HGNC Symbols for MEMO1 Gene

  • C2orf4

Previous GeneCards Identifiers for MEMO1 Gene

  • GC01U990194
  • GC02M031946
  • GC02M032092

Summaries for MEMO1 Gene

GeneCards Summary for MEMO1 Gene

MEMO1 (Mediator Of Cell Motility 1) is a Protein Coding gene. Among its related pathways are Signaling by ERBB2 and Signaling by GPCR.

UniProtKB/Swiss-Prot for MEMO1 Gene

  • May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.

Additional gene information for MEMO1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEMO1 Gene

Genomics for MEMO1 Gene

Regulatory Elements for MEMO1 Gene

Enhancers for MEMO1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H031945 1.1 Ensembl dbSUPER 10.9 +65.5 65530 0.2 LEF1 PKNOX1 ATF1 ETV1 JUN FOSL1 CTBP1 EGR1 TRIM24 ATF7 MEMO1 GC02P031938
GH02H031988 0.9 ENCODE dbSUPER 11.9 +23.6 23604 0.2 JUN CEBPB JUNB ZEB2 EP300 ATF2 JUND PRDM6 ZNF366 ZNF629 MEMO1 DPY30 SLC30A6 GC02P031938
GH02H031956 0.9 Ensembl ENCODE dbSUPER 11.2 +53.4 53444 2.8 IKZF1 RUNX3 MEMO1 DPY30 SLC30A6 GC02P031938
GH02H031963 0.9 Ensembl dbSUPER 11.2 +48.1 48130 0.2 ZNF10 MAFG BATF GATA3 ZNF316 HMBOX1 MAFK EMSY MEMO1 DPY30 SLC30A6 GC02P031938
GH02H032135 0.9 Ensembl ENCODE 10 -124.6 -124624 1.7 CTCF JUN USF2 CEBPB EP300 RAD21 ZNF592 FOSL1 ETS2 JUND SLC30A6 RNU6-647P DPY30 MEMO1 GC02P032156 GC02M032061
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MEMO1 on UCSC Golden Path with GeneCards custom track

Promoters for MEMO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000114957 1130 3001 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B

Genomic Locations for MEMO1 Gene

Genomic Locations for MEMO1 Gene
chr2:31,865,060-32,011,230
(GRCh38/hg38)
Size:
146,171 bases
Orientation:
Minus strand
chr2:32,090,129-32,236,299
(GRCh37/hg19)

Genomic View for MEMO1 Gene

Genes around MEMO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEMO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEMO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEMO1 Gene

Proteins for MEMO1 Gene

  • Protein details for MEMO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y316-MEMO1_HUMAN
    Recommended name:
    Protein MEMO1
    Protein Accession:
    Q9Y316
    Secondary Accessions:
    • B4DLS0
    • D6W575
    • Q5R2V8
    • Q5R2V9
    • Q6NSL5

    Protein attributes for MEMO1 Gene

    Size:
    297 amino acids
    Molecular mass:
    33733 Da
    Quaternary structure:
    • Interacts with ERBB2 phosphorylated on Tyr-1248.

    Three dimensional structures from OCA and Proteopedia for MEMO1 Gene

    Alternative splice isoforms for MEMO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEMO1 Gene

Post-translational modifications for MEMO1 Gene

  • Ubiquitination at Lys115
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MEMO1 Gene

Domains & Families for MEMO1 Gene

Gene Families for MEMO1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MEMO1 Gene

Suggested Antigen Peptide Sequences for MEMO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y316

UniProtKB/Swiss-Prot:

MEMO1_HUMAN :
  • Belongs to the MEMO1 family.
Family:
  • Belongs to the MEMO1 family.
genes like me logo Genes that share domains with MEMO1: view

Function for MEMO1 Gene

Molecular function for MEMO1 Gene

GENATLAS Biochemistry:
modifier of methylation for class I HLA genes,often deleted in neuroblastoma
UniProtKB/Swiss-Prot Function:
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.

Phenotypes From GWAS Catalog for MEMO1 Gene

Gene Ontology (GO) - Molecular Function for MEMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with MEMO1: view
genes like me logo Genes that share phenotypes with MEMO1: view

Animal Models for MEMO1 Gene

MGI Knock Outs for MEMO1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEMO1 Gene

Localization for MEMO1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEMO1 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MEMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16780588
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MEMO1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MEMO1 Gene

Pathways & Interactions for MEMO1 Gene

genes like me logo Genes that share pathways with MEMO1: view

Pathways by source for MEMO1 Gene

Gene Ontology (GO) - Biological Process for MEMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032886 regulation of microtubule-based process IMP 20937854
GO:2000145 regulation of cell motility TAS --
genes like me logo Genes that share ontologies with MEMO1: view

No data available for SIGNOR curated interactions for MEMO1 Gene

Drugs & Compounds for MEMO1 Gene

No Compound Related Data Available

Transcripts for MEMO1 Gene

Unigene Clusters for MEMO1 Gene

Mediator of cell motility 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEMO1 Gene

No ASD Table

Relevant External Links for MEMO1 Gene

GeneLoc Exon Structure for
MEMO1
ECgene alternative splicing isoforms for
MEMO1

Expression for MEMO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEMO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MEMO1 Gene

This gene is overexpressed in Lymph node (7.2) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MEMO1 Gene



Protein tissue co-expression partners for MEMO1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MEMO1 Gene:

MEMO1

SOURCE GeneReport for Unigene cluster for MEMO1 Gene:

Hs.444969

Evidence on tissue expression from TISSUES for MEMO1 Gene

  • Nervous system(4.1)
  • Heart(4)
  • Muscle(4)
genes like me logo Genes that share expression patterns with MEMO1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEMO1 Gene

Orthologs for MEMO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MEMO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEMO1 33
  • 99.89 (n)
dog
(Canis familiaris)
Mammalia MEMO1 33 34
  • 98.19 (n)
cow
(Bos Taurus)
Mammalia MEMO1 33 34
  • 97.2 (n)
mouse
(Mus musculus)
Mammalia Memo1 33 16 34
  • 96.07 (n)
rat
(Rattus norvegicus)
Mammalia Memo1 33
  • 96.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MEMO1 34
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MEMO1 34
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves MEMO1 33 34
  • 90.12 (n)
lizard
(Anolis carolinensis)
Reptilia MEMO1 34
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia memo1 33
  • 81.82 (n)
Str.10150 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24007 33
zebrafish
(Danio rerio)
Actinopterygii memo1 33 34
  • 76.54 (n)
wufi04d12 33
fruit fly
(Drosophila melanogaster)
Insecta CG8031 33 34
  • 61.46 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010011 33
  • 58.07 (n)
worm
(Caenorhabditis elegans)
Secernentea tag-253 33 34
  • 54.17 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MHO1 33 36
  • 48.83 (n)
-- 34
  • 35 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A11836g 33
  • 47.55 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR321W 33
  • 45.15 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G25280 33
  • 55.52 (n)
rice
(Oryza sativa)
Liliopsida Os08g0299000 33
  • 55.99 (n)
Os.8918 33
barley
(Hordeum vulgare)
Liliopsida Hv.792 33
wheat
(Triticum aestivum)
Liliopsida Ta.8110 33
corn
(Zea mays)
Liliopsida Zm.10697 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC4H3.04c 33
  • 49.05 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU11386 33
  • 48.12 (n)
Species where no ortholog for MEMO1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MEMO1 Gene

ENSEMBL:
Gene Tree for MEMO1 (if available)
TreeFam:
Gene Tree for MEMO1 (if available)

Paralogs for MEMO1 Gene

genes like me logo Genes that share paralogs with MEMO1: view

No data available for Paralogs for MEMO1 Gene

Variants for MEMO1 Gene

Sequence variations from dbSNP and Humsavar for MEMO1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000001764 -- 31,914,666(+) CATAC(A/G)TTGAG intron-variant
rs1000005803 -- 31,905,976(+) CTTTA(-/T)TTTTT intron-variant
rs1000029831 -- 31,984,441(+) TTTGT(C/T)ACAGA intron-variant
rs1000057671 -- 31,921,174(+) ATCCA(A/G)TGAGT intron-variant
rs1000081051 -- 31,960,874(+) AGCCA(A/C)CAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEMO1 Gene

Variant ID Type Subtype PubMed ID
nsv963219 CNV duplication 23825009
nsv508718 CNV deletion 20534489
nsv1134847 CNV deletion 24896259
nsv1123308 CNV deletion 24896259
esv3590235 CNV loss 21293372
esv3590233 CNV loss 21293372
esv3590232 CNV loss 21293372
esv3351835 CNV insertion 20981092
esv2719875 CNV deletion 23290073
esv2659847 CNV deletion 23128226

Variation tolerance for MEMO1 Gene

Residual Variation Intolerance Score: 36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEMO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEMO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEMO1 Gene

Disorders for MEMO1 Gene

Relevant External Links for MEMO1

Genetic Association Database (GAD)
MEMO1
Human Genome Epidemiology (HuGE) Navigator
MEMO1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEMO1

No disorders were found for MEMO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEMO1 Gene

Publications for MEMO1 Gene

  1. Memo mediates ErbB2-driven cell motility. (PMID: 15156151) Marone R … Badache A (Nature cell biology 2004) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick DM … Bierut L (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 45 60
  4. ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. (PMID: 20937854) Zaoui K … Badache A (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4 60
  5. Memo is homologous to nonheme iron dioxygenases and binds an ErbB2-derived phosphopeptide in its vestigial active site. (PMID: 18045866) Qiu C … Leahy DJ (The Journal of biological chemistry 2008) 3 4 60

Products for MEMO1 Gene

Sources for MEMO1 Gene

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