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Aliases for MELTF Gene

Aliases for MELTF Gene

  • Melanotransferrin 2 3 2
  • Antigen P97 (Melanoma Associated) Identified By Monoclonal Antibodies 133.2 And 96.5 2 3 5
  • MFI2 3 4 5
  • Membrane-Bound Transferrin-Like Protein 2 3
  • Melanoma-Associated Antigen P97 3 4
  • MAP97 3 4
  • CD228 Antigen 4
  • CD228 3
  • MTF1 3
  • MTF 3

External Ids for MELTF Gene

Previous HGNC Symbols for MELTF Gene

  • MFI2

Summaries for MELTF Gene

Entrez Gene Summary for MELTF Gene

  • The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for MELTF Gene

MELTF (Melanotransferrin) is a Protein Coding gene. Diseases associated with MELTF include Chromosome 3Q29 Microdeletion Syndrome. An important paralog of this gene is TF.

UniProtKB/Swiss-Prot for MELTF Gene

  • Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.

Gene Wiki entry for MELTF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MELTF Gene

Genomics for MELTF Gene

Regulatory Elements for MELTF Gene

Enhancers for MELTF Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MELTF on UCSC Golden Path with GeneCards custom track

Promoters for MELTF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MELTF on UCSC Golden Path with GeneCards custom track

Genomic Location for MELTF Gene

Chromosome:
3
Start:
196,987,559 bp from pter
End:
197,029,816 bp from pter
Size:
42,258 bases
Orientation:
Minus strand

Genomic View for MELTF Gene

Genes around MELTF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MELTF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MELTF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MELTF Gene

Proteins for MELTF Gene

  • Protein details for MELTF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08582-TRFM_HUMAN
    Recommended name:
    Melanotransferrin
    Protein Accession:
    P08582
    Secondary Accessions:
    • Q9BQE2

    Protein attributes for MELTF Gene

    Size:
    738 amino acids
    Molecular mass:
    80215 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MELTF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MELTF Gene

Proteomics data for MELTF Gene at MOPED

Post-translational modifications for MELTF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MELTF Gene

No data available for DME Specific Peptides for MELTF Gene

Domains & Families for MELTF Gene

Gene Families for MELTF Gene

Protein Domains for MELTF Gene

Suggested Antigen Peptide Sequences for MELTF Gene

Graphical View of Domain Structure for InterPro Entry

P08582

UniProtKB/Swiss-Prot:

TRFM_HUMAN :
  • Contains 2 transferrin-like domains.
  • Belongs to the transferrin family.
Domain:
  • Contains 2 transferrin-like domains.
Family:
  • Belongs to the transferrin family.
genes like me logo Genes that share domains with MELTF: view

Function for MELTF Gene

Molecular function for MELTF Gene

UniProtKB/Swiss-Prot Function:
Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.
genes like me logo Genes that share phenotypes with MELTF: view

Animal Models for MELTF Gene

MGI Knock Outs for MELTF:

Animal Model Products

  • Taconic Biosciences Mouse Models for MELTF

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MELTF Gene

Localization for MELTF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MELTF Gene

Isoform 1: Cell membrane; Lipid-anchor, GPI-anchor.

Gene Ontology (GO) - Cellular Components for MELTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046658 anchored component of plasma membrane IDA 7556058
genes like me logo Genes that share ontologies with MELTF: view

No data available for Subcellular locations from COMPARTMENTS for MELTF Gene

Pathways & Interactions for MELTF Gene

SuperPathways for MELTF Gene

No Data Available

Gene Ontology (GO) - Biological Process for MELTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042127 NOT regulation of cell proliferation IMP 7556058
GO:0090091 positive regulation of extracellular matrix disassembly IDA 16713448
genes like me logo Genes that share ontologies with MELTF: view

No data available for Pathways by source and SIGNOR curated interactions for MELTF Gene

Drugs & Compounds for MELTF Gene

(3) Drugs for MELTF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for MELTF Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with MELTF: view

Transcripts for MELTF Gene

Alternative Splicing Database (ASD) splice patterns (SP) for MELTF Gene

No ASD Table

Relevant External Links for MELTF Gene

GeneLoc Exon Structure for
MELTF
ECgene alternative splicing isoforms for
MELTF

Expression for MELTF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA Expression by UniProt/SwissProt for MELTF Gene

P08582-TRFM_HUMAN
Tissue specificity: Found predominantly in human melanomas and in certain fetal tissues; also found in liver, epithelium, umbilical chord, placenta and sweat gland ducts.
genes like me logo Genes that share expression patterns with MELTF: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MELTF Gene

Orthologs for MELTF Gene

This gene was present in the common ancestor of animals.

Orthologs for MELTF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MFI2 35
  • 89.31 (n)
  • 91 (a)
MFI2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MFI2 35
  • 87.31 (n)
  • 87.62 (a)
MFI2 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mfi2 35
  • 83.22 (n)
  • 84.81 (a)
Mfi2 16
Mfi2 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MFI2 35
  • 99.02 (n)
  • 98.91 (a)
MFI2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mfi2 35
  • 83.12 (n)
  • 85.51 (a)
oppossum
(Monodelphis domestica)
Mammalia MFI2 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MFI2 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves MFI2 35
  • 65.21 (n)
  • 62.91 (a)
MFI2 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MFI2 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mfi2 35
  • 59.11 (n)
  • 59.16 (a)
zebrafish
(Danio rerio)
Actinopterygii mfi2 35
  • 56.32 (n)
  • 49.71 (a)
mfi2 36
  • 47 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005003 35
  • 50.41 (n)
  • 40.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tsf2 35
  • 49.57 (n)
  • 38.47 (a)
Tsf2 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToOne
Species with no ortholog for MELTF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MELTF Gene

ENSEMBL:
Gene Tree for MELTF (if available)
TreeFam:
Gene Tree for MELTF (if available)

Paralogs for MELTF Gene

Paralogs for MELTF Gene

genes like me logo Genes that share paralogs with MELTF: view

Variants for MELTF Gene

Sequence variations from dbSNP and Humsavar for MELTF Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1056664 -- 197,019,758(+) CCTTC(C/T)TCCTC intron-variant, reference, synonymous-codon
rs481068 -- 196,993,167(-) GATTG(C/T)GCCAC intron-variant
rs481074 -- 196,993,161(-) GCCAC(C/T)GCACT intron-variant
rs482877 -- 196,998,453(-) GGCCT(C/T)GACGA intron-variant
rs2276788 -- 197,027,948(-) GGGCA(C/G/T)GGCGG intron-variant

Variation tolerance for MELTF Gene

Residual Variation Intolerance Score: 96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.25; 76.28% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MELTF Gene

Disorders for MELTF Gene

MalaCards: The human disease database

(1) MalaCards diseases for MELTF Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 3q29 microdeletion syndrome
  • 3q subtelomere deletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search MELTF in MalaCards View complete list of genes associated with diseases

Relevant External Links for MELTF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MELTF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MELTF
genes like me logo Genes that share disorders with MELTF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MELTF Gene

Publications for MELTF Gene

  1. Human melanotransferrin (p97) has only one functional iron-binding site. (PMID: 1544447) Baker E.N. … Hellstroem I. (FEBS Lett. 1992) 3 4 23 67
  2. Biochemical and spectroscopic studies of human melanotransferrin (MTf): electron-paramagnetic resonance evidence for a difference between the iron-binding site of MTf and other transferrins. (PMID: 18691669) Farnaud S. … Richardson D.R. (Int. J. Biochem. Cell Biol. 2008) 3 23
  3. Melanotransferrin induces human melanoma SK-Mel-28 cell invasion in vivo. (PMID: 17196552) Bertrand Y. … BAcliveau R. (Biochem. Biophys. Res. Commun. 2007) 3 23
  4. Plasminogen-dependent internalization of soluble melanotransferrin involves the low-density lipoprotein receptor-related protein and annexin II. (PMID: 17570828) Michaud-Levesque J. … BAcliveau R. (Biol. Chem. 2007) 3 23
  5. Melanotransferrin stimulates t-PA-dependent activation of plasminogen in endothelial cells leading to cell detachment. (PMID: 16713448) Rolland Y. … BAcliveau R. (Biochim. Biophys. Acta 2006) 3 23

Products for MELTF Gene

Sources for MELTF Gene

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