MELK Gene
protein-coding GIFtS : 61 GCID: GC09 P036562
maternal embryonic leucine zipper kinase
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Aliasesfor MELK gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Maternal Embryonic Leucine Zipper Kinase 1 2 EC 2.7.11.13 8 KIAA01751 3 5 HPK382 Protein Kinase Eg32 3 EC 2.7.10.23 Protein Kinase PK382 3 HMELK1 Tyrosine-Protein Kinase MELK2 3 HPK382 PEg3 Kinase2 3 EC 2.7.118
Export aliases for MELK gene to outside databases Previous GC identifers: GC09P036885 GC09P036742
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Summariesfor MELK gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: MELK_HUMAN, Q14680 Function : Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal ofstem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis Gene Wiki entry for MELK
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Genomic Viewsfor MELK gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000009.11 NC_018920.1 NT_008413.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MELK gene promoter:E2F-1 E2F NF-kappaB2 RelA Ik-3 NF-kappaB1 NF-kappaB Other transcription factors Search SABiosciences Chromatin IP Primers for MELK Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 9p13.2 Ensembl cytogenetic band: 9p13.2 HGNC cytogenetic band: 9p13.1 MELK Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 9 GeneLoc Exon Structure
GeneLoc location for GC09P036562: view genomic region
(about GC identifiers )
Start: 36,572,859 bp from pter End:
36,677,679 bp from pter
Size: 104,821 bases Orientation:
plus strand
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Proteinsfor MELK gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MELK_HUMAN, Q14680 See
protein sequence )Recommended Name: Size : 651 amino acids; 74642 DaSubunit : Monomer. Interacts with ZNF622 and PPP1R8Subcellular location : Cell membrane; Peripheral membrane proteinDevelopmental stage : Increases during G2/M phase compared to interphase. Protein level decreases when cells exitmitosis, probably due to degradation
Miscellaneous : Potential therapeutic target for treatment of somatic tumors, such as brain and breast cancers,down-regulation of MELK inhibiting tumorigenesis (PubMed:17960622, PubMed:20861186)
Sequence caution : Sequence=BAA11492.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;1 PDB 3D structure from :3ZGW (3D) Secondary accessions : A6P3A7 A6P3A8 B1AMQ6 B7Z1E6 B7Z6R8 B7Z6Y0 B7Z7Q1 D3DRP8 F5H2R4 Q7L3C3Alternative splicing : 6 isoforms : Q14680-1 Q14680-2 Q14680-3 Q14680-4 Q14680-5 Q14680-6 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MELK: NX_Q14680 Post-translational modifications:
Autophosphorylated: autophosphorylation of the T-loop at Thr-167 and Ser-171 is required for activation. Thr-478 phosphorylation during mitosis promotes interaction with PPP1R8 (Probable)1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q14680 4/5 DME Specific Peptides for MELK (Q14680 ) (see all 5 )MELK Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (9 alternative transcripts): NP_001243614.1 NP_001243616.1 NP_001243617.1 NP_001243618.1 NP_001243619.1 NP_001243620.1 NP_001243621.1 NP_001243622.1 NP_055606.1 ENSEMBL proteins: ENSP00000298048 ENSP00000445452 ENSP00000439792 ENSP00000437804 ENSP00000443550 ENSP00000441596 ENSP00000439184 ENSP00000438226 Human Recombinant Protein Products for MELK: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing MELK Antibody Products: Assay Products for MELK:
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Protein
Domains /for MELK gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry Q14680 ProtoNet protein and cluster: Q14680
1 Blocks protein family : IPB001772 UniProtKB/Swiss-Prot: MELK_HUMAN, Q14680 Domain : The KA1 domain mediates binding to phospholipids and targeting to membranes (By similarity)Similarity : Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamilySimilarity : Contains 1 KA1 (kinase-associated) domainSimilarity : Contains 1 protein kinase domain
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Functionfor MELK gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: MELK_HUMAN, Q14680 Function : Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal ofstem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis Catalytic activity : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphateCatalytic activity : ATP + a protein = ADP + a phosphoproteinEnzyme regulation : Activated by autophosphorylation of the T-loop at Thr-167 and Ser-171: in contrast to other membersof the SNF1 subfamily, phosphorylation at Thr-167 is not mediated by STK11/LKB1 but via autophosphorylation instead. Inhibited by calcium-binding. Kinase activity is also regulated by reducing agents: dithiothreitol (DTT) or reduced glutathione are required for kinase activity in vitro; such dependence is however not due to the presence of disulfide bonds Induction : Up-regulated in many cancers cells. Up-regulated upon treatment with radiation or 5-fluorouracil (5-FU) incolorectal cancer cells, suggesting that it might be associated with increased resistance of colorectal cells against radiation and 5-FU. Down-regulated upon siomycin A, a thiazole antibiotic, treatment, leading to inhibit tumor growth in vivo Enzyme Numbers (IUBMB): EC 2.7.11.1 1 2 EC 2.7.11 2 EC 2.7.10.2 1
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7 ): About this table
About GeneDecksing Phenotypes: 3 GenomeRNAi human phenotypes for MELK :Animal Models: Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MELK (NM_014791 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MELK Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MELK
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MELK
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Pathways & Interactionsfor MELK gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways About this table See pathways by source Super-pathway contained gene-specific pathways 1 Neuroscience
Pathway sources See GeneCards unified pathways Show all pathways 1 About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MELK STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)5/538 Interacting proteins for MELK (Q14680 1 , 2 , 3 ENSP00000298048 4 via UniProtKB, MINT, STRING , and/or I2D (see all 538 )About this table Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8 ): About this table
About GeneDecksing
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Drugs & Compoundsfor MELK gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for MELK 2 HMDB Compounds for MELK About this table 1 Novoseek chemical compound relationship for MELK gene About this table MELK
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Transcriptsfor MELK gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MELK gene (9 alternative transcripts): NM_001256685.1 NM_001256687.1 NM_001256688.1 NM_001256689.1 NM_001256690.1 NM_001256691.1 NM_001256692.1 NM_001256693.1 NM_014791.3 Unigene Cluster for MELK:
Maternal embryonic leucine zipper kinase Hs.184339 [show with all ESTs ] Unigene Representative Sequence: NR_046337 12 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000298048 ENST00000489766 ENST00000495529 ENST00000487398 ENST00000480021 ENST00000545008 (uc011lpr.2 ) ENST00000536860 (uc011lpp.2 ) ENST00000541717 (uc011lpn.2 )ENST00000536329 (uc010mlm.3 ) ENST00000543751 (uc003zzn.3 uc011lpo.2 uc010mll.3 uc011lpq.2 uc011lps.2 )ENST00000536987 (uc011lpm.2 ) ENST00000538311 (uc022bgq.1 ) Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MELK (NM_014791 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MELK Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MELK
Additional cDNA sequence: AB183427.1 AB183428.1 AB267395.1 AK222811.1 AK293284.1 AK293423.1 AK293447.1 AK296820.1 AK299164.1 AK300761.1 AK300821.1 AK301131.1 AK302374.1 AK309470.1 BC014039.2 D79997.1 NR_046337.1
12 DOTS entries : DT.212642 DT.121191399
DT.121191407 DT.121191419 DT.91711226 DT.100777414 DT.100777416 DT.102828545 DT.91742966 DT.97843505 DT.97843506 DT.100777415 24/99 AceView cDNA sequences (see all 99 ):
BQ064763 AL135150 BM851510 BU622206 AA307070 BQ071315 AI637653 NM_014791 D79997 AU124892 CR605252 BQ650221 CF141336 AL554470 AI753377 AA835959 BM927868 BM787111 BC014039 BM823308 AU133832 BE543330 BP356223 BU150260 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MELK (see all 6 ) About this scheme ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 SP1 : - - - - SP2 : - - - SP3 : - - - - SP4 : SP5 : -
ECgene alternative splicing isoforms for MELK
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Expression for MELK gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MELK expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGGTTTTGTAAbout this image MELK expression in embryonic tissues and stem cells About this table
See MELK Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MELK SOURCE GeneReport for Unigene cluster: Hs.184339 UniProtKB/Swiss-Prot: MELK_HUMAN, Q14680 Tissue specificity : Expressed in placenta, kidney, thymus, testis, ovary and intestineSABiosciences Custom PCR Arrays for MELK Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MELK
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Orthologsfor MELK gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for MELK gene from 8/26 species (see all 26 ) About this table
ENSEMBL Gene Tree for MELK (if available)TreeFam Gene Tree for MELK (if available)
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Paralogsfor MELK gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MELK gene TSSK1B 2 PRKAA2 2 HUNK 2 TSSK6 2 TSSK3 2 PRKAA1 2 TSSK2 2 TSSK4 2 STK11 2 18/81 SIMAP similar genes for MELK using alignment to 3 protein entries: MELK_HUMAN (see all proteins )
(see all similar genes ):MELKV4 BRSK2 PRKAA1 MARK4 PRKAA2 CAMK1D HUNK KIAA0999 RPS6KA5 MARK2 TRIB1 PHKG1 NEK9 CAMK1 MARK3 TRIB2 TSSK4 BRAF About GeneDecksing
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Genomic Variantsfor MELK gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 9 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for MELK (36572859 - 36677679 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MELK: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor MELK gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 607025
OMIM disorders : --UniProtKB/Swiss-Prot: MELK_HUMAN, Q14680 Note=Defects in MELK are associated with some cancers, such as brain or breast cancers. Expression is dramatically increased in aggressive undifferentiated tumors, correlating with poor patient outcome in breast and brain cancers, suggesting a role in tumor-initiating cells and proliferation via its function in cell proliferation regulation 9 : About MalaCards brain cancer hermaphroditism hematopoiesis colorectal cancer astrocytoma breast cancer glioblastoma neuronitis alcoholism Export disorders for MELK gene to outside databases
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Publicationsfor MELK gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MELK gene, integrated from 9 sources (see all 42 ):(articles sorted by number of sources associating them with MELK) Utopia : connect your pdf to the dynamic
Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849) 1 , 2 , 3(1996) Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas. (PubMed id 17960622) 1 , 2 , 9(2008) Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells. (PubMed id 17722061) 1 , 2 , 9(2008) Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family. (PubMed id 17280616) 1 , 2 , 9(2007) Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation. (PubMed id 12400006) 1 , 2 , 9(2002) Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer. (PubMed id 19671159) 1 , 2 , 9(2009) Substrate specificity and activity regulation of protein kinase MELK. (PubMed id 16216881) 1 , 2 , 9(2005) CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis. (PubMed id 15908796) 1 , 2 , 9(2005) Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1. (PubMed id 14699119) 1 , 2 , 9(2004) Siomycin A targets brain tumor stem cells partially through a MELK- mediated pathway. (PubMed id 21558073) 1 , 2 (2011)
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External Searches for MELK gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MELK gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing MELK gene
(According to HUGE )
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Specialized Databases showing MELK gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for MELK Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for MELK gene: MELK GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MELK gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
OriGene Antibodies for MELK OriGene shRNA RFP for MELK OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for MELK Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MELK OriGene 3'-UTR Clone for MELK OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MELK OriGene Custom Protein Services for MELK OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MELK QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for MELK
Search Tocris compounds for MELK
MELK Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MELK
ThermoFisher Antibodies for MELK
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MELK
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and Proteopedia 
for MELK:
Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Curated
