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MEIS3P1 Gene

pseudogene   GIFtS: 32
GCID: GC17P015689

Meis Homeobox 3 Pseudogene 1

(Previous names: Meis1, myeloid ecotropic viral integration site 1 homolog...)
(Previous symbols: MEIS3, MEIS4)
Microbiology & Infectious Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Meis Homeobox 3 Pseudogene 11 2     Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 3 (Mouse)1
MEIS31 2     Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 4 (Mouse)1
MEIS41 2     MRG22
Meis1 Homolog 3 (Mouse) Pseudogene 11     

External Ids:    HGNC: 70021   Entrez Gene: 42132   Ensembl: ENSG000001792777   UniProtKB: A6NDR63   

Export aliases for MEIS3P1 gene to outside databases

Previous GC identifers: GC17P015632 GC17P015691 GC17P015694


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MEIS3P1 Gene:
This gene appears to be a retrotransposed pseudogene based on its lack of exons compared to other family members,
one of which is found on chromosome 19 (MEIS3). It does appear to be transcribed and has an ORF that may encode a
protein of similar size and sequence to that encoded by MEIS3. (provided by RefSeq, Jul 2008)

GeneCards Summary for MEIS3P1 Gene:
MEIS3P1 (Meis homeobox 3 pseudogene 1) is a pseudogene. Diseases associated with MEIS3P1 include pulmonary function. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MEIS3P1 gene promoter:
         HOXA9B   HOXA9   SRF   SRF (504 AA)   CUTL1   Meis-1b   C/EBPalpha   AREB6   PPAR-gamma1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMEIS3P1 promoter sequence
   Search Chromatin IP Primers for MEIS3P1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEIS3P1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p12   Ensembl cytogenetic band:  17p12   HGNC cytogenetic band: 17p12

MEIS3P1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEIS3P1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P015689:  view genomic region     (about GC identifiers)

Start:
15,689,932 bp from pter      End:
15,693,019 bp from pter
Size:
3,088 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ME3L1_HUMAN, A6NDR6 (See protein sequence)
Recommended Name: Putative homeobox protein Meis3-like 1  
Size: 274 amino acids; 30204 Da
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for MEIS3P1: NX_A6NDR6

Explore proteomics data for MEIS3P1 at MOPED


See MEIS3P1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
TALE: Homeoboxes / TALE class

3 InterPro protein domains:
 IPR008422 Homeobox_KN_domain
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry A6NDR6

ProtoNet protein and cluster: A6NDR6

UniProtKB/Swiss-Prot: ME3L1_HUMAN, A6NDR6
Similarity: Belongs to the TALE/MEIS homeobox family
Similarity: Contains 1 homeobox DNA-binding domain


MEIS3P1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding IEA--
     
MEIS3P1 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ME3L1_HUMAN, A6NDR6: Nucleus (By similarity)

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

MEIS3P1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MEIS3P1
Interactions:

    Search GeneGlobe Interaction Network for MEIS3P1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for MEIS3P1 (ME3L1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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Unigene Cluster for MEIS3P1:

Meis homeobox 3 pseudogene 1
Hs.356135  [show with all ESTs]
Unigene Representative Sequence: NR_002211
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000495167(uc002gpc.3)
Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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Additional mRNA sequence: 

AK054814.1 NR_002211.1 U68385.1 

3 DOTS entries:

DT.95179990  DT.95072800  DT.91662826 

Selected AceView cDNA sequences (see all 47):

BE644900 BU686816 AW270098 AI393146 AI633525 BQ575773 AI079175 AW468707 
BF434206 AA846880 BU685266 AI278906 BM463727 BU507682 AI077945 AI720007 
AI186723 AK054814 AA700511 BU568566 CA411659 AA343036 AJ009667 AI383066 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MEIS3P1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTAGAATAG
MEIS3P1 Expression
About this image

MEIS3P1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MEIS3P1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.356135
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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEIS3P1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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ENSEMBL Gene Tree for MEIS3P1 (if available)
TreeFam Gene Tree for MEIS3P1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MEIS3P1 gene
11 SIMAP similar genes for MEIS3P1 using alignment to 1 protein entry:     ME3L1_HUMAN:
HB103    MEIS3P2    MEIS3    MEIS1    MEIS2    TGIF2LY
TGIF1    PKNOX2    PKNOX1    meis1    WUGSC

MEIS3P1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MEIS3P1 (see all 101)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1447247641,2
--15688186(+) CATCAA/GTGAAG 1 -- us2k10--------
rs1468227031,2
--15688269(+) GATTTG/TAAAAA 1 -- us2k10--------
rs1404795811,2
--15688275(+) AAAAAA/GTCTTC 1 -- us2k10--------
rs1504246391,2
--15688290(+) TCTGAA/GGATGA 1 -- us2k10--------
rs1912936531,2
--15688340(+) ATGAGC/TTATTT 1 -- us2k10--------
rs1827632661,2
C--15688348(+) TTTCCA/TTTCCA 1 -- us2k10--------
rs1876424901,2
--15688404(+) CCTCAC/GATTAG 1 -- us2k10--------
rs5089591,2
C,F,A,H--15688491(+) TTGTTT/CTGCTA 1 -- us2k119Minor allele frequency- C:0.33EA NA MN NS WA CSA 2201
rs1932229311,2
--15688541(+) TGCTTA/GGCGAG 1 -- us2k10--------
rs1838775781,2
--15688607(+) ATATAA/CAAGAT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for MEIS3P1 (15689932 - 15693019 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for MEIS3P1:    About this table    
Variant IDTypeSubtypePubMed ID
esv2715702CNV Deletion23290073
nsv907705CNV Gain21882294
nsv442411CNV CNV18776908

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for MEIS3P1:    
About MalaCards
pulmonary function


MEIS3P1 for disorders           About GeneDecksing

Genetic Association Database (GAD): MEIS3P1

Export disorders for MEIS3P1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MEIS3P1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with MEIS3P1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (Nature 2006)
  2. Identification of a conserved family of Meis1-related homeobox genes. (PubMed id 9049632)1, 3 Steelman S.... Buchberg A.M. (Genome Res. 1997)
  3. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)4 Seshadri S....Wolf P.A. (BMC Med. Genet. 2007)
  4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
  5. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PubMed id 17903307)4 Wilk J.B....O'Connor G.T. (BMC Med. Genet. 2007)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  7. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4213 HGNC: 7002 AceView: MEIS4 Ensembl:ENSG00000179277 euGenes: HUgn4213
ECgene: MEIS3P1 H-InvDB: MEIS3P1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MEIS3P1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MEIS3P1 gene:
Search GeneIP for patents involving MEIS3P1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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