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Aliases for MEIS3 Gene

Aliases for MEIS3 Gene

  • Meis Homeobox 3 2 3 5
  • Meis1-Related Protein 2 3 4
  • MRG2 3 4
  • Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 3 (Mouse) 2
  • Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 3 3
  • Homeobox Protein Meis3 3

External Ids for MEIS3 Gene

Previous GeneCards Identifiers for MEIS3 Gene

  • GC17P016056
  • GC17P016804
  • GC17P015633
  • GC19M052598
  • GC19M047906

Summaries for MEIS3 Gene

Entrez Gene Summary for MEIS3 Gene

  • This gene encodes a homeobox protein and probable transcriptional regulator. The orthologous protein in mouse controls expression of 3-phosphoinositide dependent protein kinase 1, which promotes survival of pancreatic beta-cells. [provided by RefSeq, Sep 2016]

GeneCards Summary for MEIS3 Gene

MEIS3 (Meis Homeobox 3) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is MEIS2.

UniProtKB/Swiss-Prot for MEIS3 Gene

  • Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEIS3 Gene

Genomics for MEIS3 Gene

Regulatory Elements for MEIS3 Gene

Enhancers for MEIS3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G047496 1.2 ENCODE dbSUPER 11.9 -75.4 -75382 1.9 HDAC1 PKNOX1 ATF1 TBL1XR1 CREB3L1 ARNT AGO1 SIN3A TCF12 ZNF766 MEIS3 ZNF541 BICRA TMEM143 ENSG00000279861 NAPA
GH19G047494 1 ENCODE dbSUPER 11.9 -72.9 -72907 1.8 MXI1 PKNOX1 L3MBTL2 NRF1 BHLHE40 CEBPB REST EP300 GATA3 POLR2A MEIS3 ZNF541 BICRA TMEM143 ENSG00000279861 NAPA
GH19G047492 0.8 dbSUPER 11.9 -71.0 -70995 1.6 AGO1 YBX1 ZIC2 ZFHX2 ZNF776 ZNF366 ZNF157 POLR2A SCRT2 PCBP1 ZC3H4 BICRA NAPA MEIS3 NOP53-AS1 ZNF541 PPP5D1 KPTN ENSG00000279861
GH19G047351 1.4 FANTOM5 Ensembl ENCODE 6.3 +70.3 70343 0.6 ATF1 MAX ZNF644 CHAMP1 RFX5 DIDO1 GATAD1 GATA2 RFXANK NFYB C5AR2 DHX34 C5AR1 MEIS3 CCDC9 ZC3H4 NAPA BBC3 PIR41927 GC19P047354
GH19G047348 1.1 ENCODE 6.3 +72.9 72868 1.9 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ENSG00000268810 DHX34 ZC3H4 SLC1A5 NOP53-AS1 CCDC9 MEIS3 PIR41927 GC19P047354
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MEIS3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MEIS3 Gene

Chromosome:
19
Start:
47,403,118 bp from pter
End:
47,422,265 bp from pter
Size:
19,148 bases
Orientation:
Minus strand

Genomic View for MEIS3 Gene

Genes around MEIS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEIS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEIS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEIS3 Gene

Proteins for MEIS3 Gene

  • Protein details for MEIS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99687-MEIS3_HUMAN
    Recommended name:
    Homeobox protein Meis3
    Protein Accession:
    Q99687
    Secondary Accessions:
    • A8K1N5
    • Q6NT73
    • Q8TC66
    • Q9NPW2

    Protein attributes for MEIS3 Gene

    Size:
    375 amino acids
    Molecular mass:
    41115 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MEIS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEIS3 Gene

Post-translational modifications for MEIS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for MEIS3 Gene

Domains & Families for MEIS3 Gene

Gene Families for MEIS3 Gene

Protein Domains for MEIS3 Gene

Suggested Antigen Peptide Sequences for MEIS3 Gene

Graphical View of Domain Structure for InterPro Entry

Q99687

UniProtKB/Swiss-Prot:

MEIS3_HUMAN :
  • Belongs to the TALE/MEIS homeobox family.
Family:
  • Belongs to the TALE/MEIS homeobox family.
genes like me logo Genes that share domains with MEIS3: view

Function for MEIS3 Gene

Molecular function for MEIS3 Gene

GENATLAS Biochemistry:
homeo domain protein,murine Meis1 (myeloid ecotropic viral integration site 1) ortholog,PBX1 related,ubiquitously expressed,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors
UniProtKB/Swiss-Prot Function:
Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1.

Gene Ontology (GO) - Molecular Function for MEIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0043565 sequence-specific DNA binding IDA 17178831
genes like me logo Genes that share ontologies with MEIS3: view

Phenotypes for MEIS3 Gene

MGI mutant phenotypes for MEIS3:
inferred from 1 alleles
GenomeRNAi human phenotypes for MEIS3:
genes like me logo Genes that share phenotypes with MEIS3: view

Animal Models for MEIS3 Gene

MGI Knock Outs for MEIS3:

Animal Model Products

CRISPR Products

miRNA for MEIS3 Gene

miRTarBase miRNAs that target MEIS3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEIS3 Gene

Localization for MEIS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEIS3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEIS3 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MEIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MEIS3: view

Pathways & Interactions for MEIS3 Gene

SuperPathways for MEIS3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
GO:0051897 positive regulation of protein kinase B signaling IEA --
GO:2001234 negative regulation of apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with MEIS3: view

No data available for Pathways by source and SIGNOR curated interactions for MEIS3 Gene

Drugs & Compounds for MEIS3 Gene

No Compound Related Data Available

Transcripts for MEIS3 Gene

Unigene Clusters for MEIS3 Gene

Meis homeobox 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEIS3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: - - -
SP3:
SP4:
SP5: - -

Relevant External Links for MEIS3 Gene

GeneLoc Exon Structure for
MEIS3
ECgene alternative splicing isoforms for
MEIS3

Expression for MEIS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEIS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEIS3 Gene

This gene is overexpressed in Brain - Amygdala (x4.5), Uterus (x4.4), Brain - Anterior cingulate cortex (BA24) (x4.3), and Brain - Cortex (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of MEIS3 Gene:

MEIS3

SOURCE GeneReport for Unigene cluster for MEIS3 Gene:

Hs.380923

Evidence on tissue expression from TISSUES for MEIS3 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with MEIS3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEIS3 Gene

Orthologs for MEIS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MEIS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEIS3 34 35
  • 98.97 (n)
cow
(Bos Taurus)
Mammalia MEIS3 34 35
  • 90.64 (n)
dog
(Canis familiaris)
Mammalia MEIS3 34 35
  • 90.59 (n)
rat
(Rattus norvegicus)
Mammalia Meis3 34
  • 87.11 (n)
mouse
(Mus musculus)
Mammalia Meis3 34 16 35
  • 86.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 22 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 73 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC52546 34
zebrafish
(Danio rerio)
Actinopterygii meis3 35
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta hth 35
  • 42 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3310 34
Species where no ortholog for MEIS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEIS3 Gene

ENSEMBL:
Gene Tree for MEIS3 (if available)
TreeFam:
Gene Tree for MEIS3 (if available)

Paralogs for MEIS3 Gene

Paralogs for MEIS3 Gene

Pseudogenes.org Pseudogenes for MEIS3 Gene

genes like me logo Genes that share paralogs with MEIS3: view

Variants for MEIS3 Gene

Sequence variations from dbSNP and Humsavar for MEIS3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs140643747 Benign 47,416,947(+) CAAGA(C/G/T)GGGGA reference, missense, utr-variant-5-prime
rs1000020503 -- 47,409,726(+) GGTGT(A/G)GTGGC intron-variant
rs1000087745 -- 47,403,890(+) ATAGA(C/T)GAAAT intron-variant
rs1000559046 -- 47,405,770(+) GTCTC(C/G)AACTT intron-variant
rs1000980476 -- 47,420,720(+) AGAGA(C/T)GAGCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MEIS3 Gene

Variant ID Type Subtype PubMed ID
esv2479786 CNV loss 19546169
esv2758765 CNV loss 17122850
nsv1057003 CNV loss 25217958
nsv428366 CNV loss 18775914
nsv517901 CNV loss 19592680
nsv521341 CNV gain 19592680
nsv9738 CNV gain 18304495

Variation tolerance for MEIS3 Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEIS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEIS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEIS3 Gene

Disorders for MEIS3 Gene

Relevant External Links for MEIS3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEIS3

No disorders were found for MEIS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEIS3 Gene

Publications for MEIS3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Identification of a conserved family of Meis1-related homeobox genes. (PMID: 9049632) Steelman S. … Buchberg A.M. (Genome Res. 1997) 3 4 64
  3. Identification of a new family of Pbx-related homeobox genes. (PMID: 8950991) Nakamura T. … Copeland N.G. (Oncogene 1996) 2 3 64
  4. MEIS3 is repressed in A549 lung epithelial cells by deoxynivalenol and the repression contributes to the deleterious effect. (PMID: 26763390) Toyotome T. … Kamei K. (J Toxicol Sci 2016) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for MEIS3 Gene

Sources for MEIS3 Gene

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