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Aliases for MEIS3 Gene

Aliases for MEIS3 Gene

  • Meis Homeobox 3 2 3 5
  • Meis1-Related Protein 2 3 4
  • MRG2 3 4
  • Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 3 (Mouse) 2
  • Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 3 3

External Ids for MEIS3 Gene

Previous GeneCards Identifiers for MEIS3 Gene

  • GC17P016056
  • GC17P016804
  • GC17P015633
  • GC19M052598
  • GC19M047906

Summaries for MEIS3 Gene

GeneCards Summary for MEIS3 Gene

MEIS3 (Meis Homeobox 3) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is PKNOX1.

UniProtKB/Swiss-Prot for MEIS3 Gene

  • Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEIS3 Gene

Genomics for MEIS3 Gene

Regulatory Elements for MEIS3 Gene

Enhancers for MEIS3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MEIS3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MEIS3 Gene

Chromosome:
19
Start:
47,403,118 bp from pter
End:
47,422,265 bp from pter
Size:
19,148 bases
Orientation:
Minus strand

Genomic View for MEIS3 Gene

Genes around MEIS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEIS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEIS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEIS3 Gene

Proteins for MEIS3 Gene

  • Protein details for MEIS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99687-MEIS3_HUMAN
    Recommended name:
    Homeobox protein Meis3
    Protein Accession:
    Q99687
    Secondary Accessions:
    • A8K1N5
    • Q6NT73
    • Q8TC66
    • Q9NPW2

    Protein attributes for MEIS3 Gene

    Size:
    375 amino acids
    Molecular mass:
    41115 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MEIS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEIS3 Gene

Proteomics data for MEIS3 Gene at MOPED

Post-translational modifications for MEIS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MEIS3 Gene

Domains & Families for MEIS3 Gene

Gene Families for MEIS3 Gene

Protein Domains for MEIS3 Gene

Suggested Antigen Peptide Sequences for MEIS3 Gene

Graphical View of Domain Structure for InterPro Entry

Q99687

UniProtKB/Swiss-Prot:

MEIS3_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/MEIS homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the TALE/MEIS homeobox family.
genes like me logo Genes that share domains with MEIS3: view

Function for MEIS3 Gene

Molecular function for MEIS3 Gene

GENATLAS Biochemistry:
homeo domain protein,murine Meis1 (myeloid ecotropic viral integration site 1) ortholog,PBX1 related,ubiquitously expressed,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors
UniProtKB/Swiss-Prot Function:
Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1.

Gene Ontology (GO) - Molecular Function for MEIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
genes like me logo Genes that share ontologies with MEIS3: view

Phenotypes for MEIS3 Gene

MGI mutant phenotypes for MEIS3:
inferred from 1 alleles
GenomeRNAi human phenotypes for MEIS3:
genes like me logo Genes that share phenotypes with MEIS3: view

Animal Models for MEIS3 Gene

MGI Knock Outs for MEIS3:

Animal Model Products

miRNA for MEIS3 Gene

miRTarBase miRNAs that target MEIS3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEIS3 Gene

Localization for MEIS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEIS3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEIS3 Gene COMPARTMENTS Subcellular localization image for MEIS3 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for MEIS3 Gene

Pathways & Interactions for MEIS3 Gene

SuperPathways for MEIS3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051897 positive regulation of protein kinase B signaling IEA --
genes like me logo Genes that share ontologies with MEIS3: view

No data available for Pathways by source and SIGNOR curated interactions for MEIS3 Gene

Drugs & Compounds for MEIS3 Gene

No Compound Related Data Available

Transcripts for MEIS3 Gene

Unigene Clusters for MEIS3 Gene

Meis homeobox 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEIS3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: - - -
SP3:
SP4:
SP5: - -

Relevant External Links for MEIS3 Gene

GeneLoc Exon Structure for
MEIS3
ECgene alternative splicing isoforms for
MEIS3

Expression for MEIS3 Gene

mRNA expression in normal human tissues for MEIS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEIS3 Gene

This gene is overexpressed in Brain - Amygdala (x4.5), Uterus (x4.4), Brain - Anterior cingulate cortex (BA24) (x4.3), and Brain - Cortex (x4.3).

SOURCE GeneReport for Unigene cluster for MEIS3 Gene Hs.380923

genes like me logo Genes that share expression patterns with MEIS3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MEIS3 Gene

Orthologs for MEIS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MEIS3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MEIS3 35
  • 90.64 (n)
  • 94.1 (a)
MEIS3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEIS3 35
  • 90.59 (n)
  • 94.09 (a)
MEIS3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Meis3 35
  • 86.76 (n)
  • 90.13 (a)
Meis3 16
Meis3 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MEIS3 35
  • 98.97 (n)
  • 98.31 (a)
MEIS3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Meis3 35
  • 87.11 (n)
  • 91.2 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 22 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 73 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC52546 35
zebrafish
(Danio rerio)
Actinopterygii meis3 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta hth 36
  • 42 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3310 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for MEIS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEIS3 Gene

ENSEMBL:
Gene Tree for MEIS3 (if available)
TreeFam:
Gene Tree for MEIS3 (if available)

Paralogs for MEIS3 Gene

Paralogs for MEIS3 Gene

Pseudogenes.org Pseudogenes for MEIS3 Gene

genes like me logo Genes that share paralogs with MEIS3: view

Variants for MEIS3 Gene

Sequence variations from dbSNP and Humsavar for MEIS3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12976137 -- 47,420,912(+) CTCTC(A/T)CACAC intron-variant, upstream-variant-2KB
rs7359878 -- 47,423,203(+) tctct(C/G)tgtct upstream-variant-2KB
rs7359879 -- 47,423,221(+) tgtct(C/G/T)tgtgt upstream-variant-2KB
rs7359881 -- 47,423,227(+) tgtgt(C/G)tctct upstream-variant-2KB
rs7359885 -- 47,422,812(+) ccctc(C/T)ctgtc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MEIS3 Gene

Variant ID Type Subtype PubMed ID
dgv1107e1 CNV Complex 17122850
nsv428366 CNV Loss 18775914
nsv912201 CNV Loss 21882294
nsv9738 CNV Gain 18304495
nsv521341 CNV Gain 19592680
nsv517901 CNV Loss 19592680
esv2479786 CNV Loss 19546169

Variation tolerance for MEIS3 Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MEIS3 Gene

Disorders for MEIS3 Gene

Relevant External Links for MEIS3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEIS3

No disorders were found for MEIS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEIS3 Gene

Publications for MEIS3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Identification of a new family of Pbx-related homeobox genes. (PMID: 8950991) Nakamura T. … Copeland N.G. (Oncogene 1996) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. An autoinhibitory effect of the homothorax domain of Meis2. (PMID: 20553494) Hyman-Walsh C. … Wotton D. (FEBS J. 2010) 3
  5. Regulation of EphA8 gene expression by TALE homeobox transcription factors during development of the mesencephalon. (PMID: 17178831) Shim S. … Park S. (Mol. Cell. Biol. 2007) 3

Products for MEIS3 Gene

Sources for MEIS3 Gene

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