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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MEIS3 Gene

protein-coding GIFtS: 45
GCID: GC19M047906

Meis homeobox 3

(Previous names: Meis1, myeloid ecotropic viral integration site 1 homolog...)

Explore 1 disease affiliated with
MEIS3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Meis Homeobox 3¹ ²		Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 3 (Mouse)¹
MRG2¹ ² ³		Homeobox Protein Meis3²
Meis1-Related Protein 2² ³		Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 3²
DKFZp547H236¹

External Ids:	HGNC: 29537¹	Entrez Gene: 56917²	Ensembl: ENSG00000105419⁷	UniProtKB: Q99687³

Export aliases for MEIS3 gene to outside databases

Previous GC identifers: GC17P016056 GC17P016804 GC17P015633 GC19M052598

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MEIS3 gene promoter:
CREB USF1 USF-1 NRSF form 1 CUTL1 E4BP4 NRSF form 2 YY1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MEIS3 promoter sequence

Search SABiosciences Chromatin IP Primers for MEIS3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEIS3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.32

MEIS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEIS3 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M047906: view genomic region (about GC identifiers)

Start:	47,906,316 bp from pter	End:	47,922,785 bp from pter
Size:	16,470 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MEIS3_HUMAN, Q99687 (See protein sequence)

Recommended Name: Homeobox protein Meis3

Size: 375 amino acids; 41115 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: A8K1N5 Q6NT73 Q8TC66 Q9NPW2

Alternative splicing: 3 isoforms: Q99687-1 Q99687-2 Q99687-3

Explore the universe of human proteins at neXtProt for MEIS3: NX_Q99687

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q99687

MEIS3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001009813.1 NP_064545.1

ENSEMBL proteins:

ENSP00000333552 ENSP00000453203 ENSP00000388667 ENSP00000453757 ENSP00000453934

ENSP00000453307 ENSP00000452841 ENSP00000453698 ENSP00000454073 ENSP00000452854

ENSP00000453249

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): MEIS3 OriGene Protein Over-expression Lysate (see all 3): MEIS3 OriGene Custom Protein Services for MEIS3
	GenScript Custom Purified and Recombinant Proteins Services for MEIS3
	Novus Biologicals MEIS3 Proteins Novus Biologicals MEIS3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MEIS3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

MEIS3 for ontologies About GeneDecksing

MEIS3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Novus Biologicals MEIS3 Antibodies
	Search for Antibodies for MEIS3 at Abcam
	Uscn Antibodies for MEIS3
	Search ThermoFisher Antibodies for MEIS3

Assay Products for MEIS3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MEIS3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MEIS3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MEIS3 for domains About GeneDecksing

3 InterPro domains/families:

IPR008422 Homeobox_KN_domain

IPR001356 Homeodomain

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q99687

ProtoNet protein and cluster: Q99687

UniProtKB/Swiss-Prot: MEIS3_HUMAN, Q99687

Similarity: Belongs to the TALE/MEIS homeobox family

Similarity: Contains 1 homeobox DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

Genatlas biochemistry entry for MEIS3:

homeo domain protein,murine Meis1 (myeloid ecotropic viral integration site 1) ortholog,PBX1 related,ubiquitously

expressed,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MEIS3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEIS3
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate MEIS3 (see all 11):
		hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-miR-374a* hsa-let-7g hsa-let-7e hsa-miR-499-5p

		SwitchGear 3'UTR luciferase reporter plasmid: MEIS3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEIS3 (see all 4) OriGene shRNA RFP: MEIS3 OriGene siRNA: MEIS3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEIS3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MEIS3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEIS3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEIS3 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for MEIS3
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEIS3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEIS3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MEIS3
		Search LifeMap BioReagents cell lines for MEIS3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEIS3

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IEA	--
GO:0003682	chromatin binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	--	--
GO:0043565	sequence-specific DNA binding	IDA	17178831

MEIS3 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MEIS3:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MEIS3

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

3 Interacting proteins for MEIS3 (Q99687³ ENSP00000333552⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HOXA13	P31271³, ENSP00000222753⁴	I2D: score=3 STRING: ENSP00000222753
JDP2	Q8WYK2³	I2D: score=1
PBX4	Q9BYU1³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0043066	negative regulation of apoptotic process	IEA	--
GO:0051897	positive regulation of protein kinase B signaling cascade	IEA	--

MEIS3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MEIS3
Search CenterWatch for drugs/clinical trials and news about MEIS3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MEIS3 gene (2 alternative transcripts):

NM_001009813.2 NM_020160.2

Unigene Cluster for MEIS3:

Meis homeobox 3

Hs.741404 [show with all ESTs]

Unigene Representative Sequence: NM_020160

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000331559(uc002pgs.3 uc002pgt.3 uc010eld.3) ENST00000559890

ENST00000561204(uc002pgr.3) ENST00000441740 ENST00000560245(uc002pgp.3)

ENST00000561096(uc002pgq.3) ENST00000561293 ENST00000560253(uc002pgo.3)

ENST00000559688 ENST00000558555 ENST00000559524 ENST00000559338 ENST00000557833

ENST00000561040(uc002pgw.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MEIS3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEIS3
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate MEIS3 (see all 11):
		hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-miR-374a* hsa-let-7g hsa-let-7e hsa-miR-499-5p

		SwitchGear 3'UTR luciferase reporter plasmid: MEIS3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEIS3 (see all 4) OriGene shRNA RFP: MEIS3 OriGene siRNA: MEIS3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEIS3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEIS3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEIS3 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for MEIS3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEIS3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEIS3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEIS3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MEIS3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEIS3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEIS3

Additional cDNA sequence:

AB209455.1 AK098710.1 AK289950.1 AY091593.1 BC014430.1 BC025404.1 BC042183.1 BC045741.1

BC069251.1

18 DOTS entries:

DT.40215875 DT.95072774 DT.100757358 DT.121502990 DT.97847939 DT.91944163 DT.101961250 DT.121502992

DT.101981371 DT.100783117 DT.121503012 DT.91703329 DT.100702575 DT.95179990 DT.97793175 DT.101960952

DT.91662826 DT.97856979

24/121 AceView cDNA sequences (see all 121):

BM783752 BM759794 T10795 BX394586 CK821639 AA365980 BM783223 CR613863

BQ279147 AA378474 CR596359 AK126593 CR605977 BM311750 BM783530 AK098710

BM931531 BC025404 CR612502 AI280810 BQ225399 BM783677 BM783116 CR613682

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for MEIS3 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13
SP1:
SP2:			-		-		-
SP3:
SP4:
SP5:					-		-

ECgene alternative splicing isoforms for MEIS3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MEIS3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGGCCTGAG

About this image
See MEIS3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MEIS3

SOURCE GeneReport for Unigene cluster: Hs.741404

SABiosciences Custom PCR Arrays for MEIS3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEIS3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MEIS3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEIS3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEIS3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEIS3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MEIS3 gene from 8/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Meis3^{1 , 5}	Meis homeobox 3^{1, 5}	86.13(n)¹ 89.66(a)¹		7 (8.76 cM)⁵ 17537¹ NM_008627.2¹ NP_032653.2¹ 16175090⁵
lizard (Anolis carolinensis)	Reptilia	MEIS3⁶	--	65(a)	possible ortholog	GL344351.1(8818-12530)
African clawed frog (Xenopus laevis)	Amphibia	MGC52546²	similar to myeloid ecotropic viral integration site-related more	76.26(n)		BC044024.1
zebrafish (Danio rerio)	Actinopterygii	meis3¹	myeloid ecotropic viral integration site 3	66.17(n) 68.56(a)		81885 NM_131778.1 NP_571853.1
fruit fly (Drosophila melanogaster)	Insecta	hth⁶	homothorax	39(a)	1 → many	3R(6335569-6464386)
worm (Caenorhabditis elegans)	Secernentea	unc-62⁶	Homeobox protein unc-62	24(a)	1 → many	V(4497449-4511435)
thale cress (Arabidopsis thaliana)	eudicotyledons	BLH10⁶ BEL1⁶ (see all 13)	homeobox protein BEL1-like protein (see all 13)	9(a) 9(a) (see all 13)	many ↔ many many ↔ many (see all 13)	1(6809724-6812663) 5(16580044-16584008)
rice (Oryza sativa)	Liliopsida	-- -- (see all 14)	homeobox domain containing protein, expressed (see all 14)	9(a) 9(a) (see all 14)	many ↔ many many ↔ many (see all 14)	10(20730228-20735139) 6(522054-529058)

ENSEMBL Gene Tree for MEIS3 (if available)
TreeFam Gene Tree for MEIS3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MEIS3 gene

TGIF2LY² MEIS2² PKNOX1² TGIF2² PKNOX2² TGIF2LX² TGIF1² MEIS1²

11 SIMAP similar genes for MEIS3 using alignment to 9 protein entries: MEIS3_HUMAN (see all proteins):

HB103 MEIS3P2 MEIS3P1 MEIS1 MEIS2 meis1

TGIF2LY PKNOX1 TGIF1 PKNOX2 WUGSC

MEIS3 for paralogs About GeneDecksing

4 Pseudogenes.org Pseudogenes for MEIS3
PGOHUM00000237233 PGOHUM00000262123 PGOHUM00000237290 PGOHUM00000262124

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141640849^1,2		--	47906132(+)	`CAGGCA/GTGCAC`	2	--	ds500¹		0	--	--	--	--
rs12610894^1,2	C,F,H,	--	47906154(+)	`AGCAAT/CTCGTT`	2	--	ds500¹		5		NA WA EA	364
rs185155432^1,2		--	47906234(+)	`CCACTC/TGCCTT`	2	--	ds500¹		0	--	--	--	--
rs200674772^1,2		--	47906405(+)	`TCATT-/AAAAAA`	2	--	ut3¹		0	--	--	--	--
rs1880853^1,2	C,F,A,H,	--	47906491(+)	`ACCCTC/ACTTCC`	2	--	ut3¹ ese³ trp³		7		NS EA NA MN	604
rs11556637^1,2	C,	--	47906518(+)	`CCCGTC/GCCTTC`	2	--	ut3¹ ese³ trp³		2		NA	4
rs190406454^1,2		--	47906535(+)	`CTGGCA/GGCGAG`	2	--	ut3¹		0	--	--	--	--
rs181268858^1,2		--	47906586(+)	`CAGCTC/TGGGTC`	2	--	ut3¹		0	--	--	--	--
rs12620^1,2		--	47906711(-)	`CTCAAC/TGCCTA`	2	--	ut3¹ ese³		3		MN NA	192
rs113115068^1,2		--	47906982(+)	`GTGACG/AAGAAA`	2	--	int¹		2		CSA WA	120

HapMap Linkage Disequilibrium report for MEIS3 (47906316 - 47922785 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for MEIS3
3 CNVs: 102856 4083 30911

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEIS3

DNA2.0 Custom Variant and Variant Library Synthesis for MEIS3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MEIS3 for disorders About GeneDecksing

1 disease for MEIS3: About MalaCards

neuronitis

Export disorders for MEIS3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MEIS3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MEIS3)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification of a conserved family of Meis1-related homeobox genes. (PubMed id 9049632)^{1, 2} Steelman S.... Buchberg A.M. (1997)
Identification of a new family of Pbx-related homeobox genes. (PubMed id 8950991)^{1, 3} Nakamura T....Copeland N.G. (1996)
An autoinhibitory effect of the homothorax domain of Meis2. (PubMed id 20553494)¹ Hyman-Walsh C....Wotton D. (2010)
Regulation of EphA8 gene expression by TALE homeobox transcription factors during development of the mesencephalon. (PubMed id 17178831)¹ Shim S....Park S. (2007)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction. (PubMed id 15617687)¹ Williams T.M....Innis J.W. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 56917	HGNC: 29537	AceView: MEIS3	Ensembl:ENSG00000105419	euGenes: HUgn56917
ECgene: MEIS3	H-InvDB: MEIS3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MEIS3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MEIS3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MEIS3 gene:
Search GeneIP for patents involving MEIS3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	Regulatory tfbs in MEIS3 promoter
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEIS3

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Search ThermoFisher Antibodies for MEIS3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEIS3

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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MEIS3 Gene

Meis homeobox 3

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MEIS3 Gene

Meis homeobox 3

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Intellectual Property
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