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Aliases for MEIS3 Gene

Aliases for MEIS3 Gene

  • Meis Homeobox 3 2 3
  • Meis1-Related Protein 2 3 4
  • MRG2 3 4
  • Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 3 (Mouse) 2
  • Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 3 3
  • Homeobox Protein Meis3 3

External Ids for MEIS3 Gene

Previous GeneCards Identifiers for MEIS3 Gene

  • GC17P016056
  • GC17P016804
  • GC17P015633
  • GC19M052598
  • GC19M047906

Summaries for MEIS3 Gene

GeneCards Summary for MEIS3 Gene

MEIS3 (Meis Homeobox 3) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is TGIF2LY.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEIS3 Gene

Genomics for MEIS3 Gene

Regulatory Elements for MEIS3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MEIS3 Gene

Start:
47,403,118 bp from pter
End:
47,419,528 bp from pter
Size:
16,411 bases
Orientation:
Minus strand

Genomic View for MEIS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEIS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEIS3 Gene

Proteins for MEIS3 Gene

  • Protein details for MEIS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99687-MEIS3_HUMAN
    Recommended name:
    Homeobox protein Meis3
    Protein Accession:
    Q99687
    Secondary Accessions:
    • A8K1N5
    • Q6NT73
    • Q8TC66
    • Q9NPW2

    Protein attributes for MEIS3 Gene

    Size:
    375 amino acids
    Molecular mass:
    41115 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MEIS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEIS3 Gene

Proteomics data for MEIS3 Gene at MOPED

Post-translational modifications for MEIS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MEIS3 Gene

Domains for MEIS3 Gene

Gene Families for MEIS3 Gene

HGNC:
  • TALE :Homeoboxes / TALE class

Protein Domains for MEIS3 Gene

Suggested Antigen Peptide Sequences for MEIS3 Gene

Graphical View of Domain Structure for InterPro Entry

Q99687

UniProtKB/Swiss-Prot:

MEIS3_HUMAN :
  • Q99687
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the TALE/MEIS homeobox family.
genes like me logo Genes that share domains with MEIS3: view

Function for MEIS3 Gene

Molecular function for MEIS3 Gene

GENATLAS Biochemistry: homeo domain protein,murine Meis1 (myeloid ecotropic viral integration site 1) ortholog,PBX1 related,ubiquitously expressed,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors

Gene Ontology (GO) - Molecular Function for MEIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0043565 sequence-specific DNA binding IDA 17178831
genes like me logo Genes that share ontologies with MEIS3: view

Phenotypes for MEIS3 Gene

MGI mutant phenotypes for MEIS3:
inferred from 1 alleles
GenomeRNAi human phenotypes for MEIS3:
genes like me logo Genes that share phenotypes with MEIS3: view

Animal Model Products

CRISPR Products

miRNA for MEIS3 Gene

miRTarBase miRNAs that target MEIS3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MEIS3 Gene

Localization for MEIS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEIS3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEIS3 Gene COMPARTMENTS Subcellular localization image for MEIS3 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MEIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MEIS3: view

Pathways for MEIS3 Gene

SuperPathways for MEIS3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
GO:0051897 positive regulation of protein kinase B signaling IEA --
GO:2001234 negative regulation of apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with MEIS3: view

No data available for Pathways by source for MEIS3 Gene

Transcripts for MEIS3 Gene

Unigene Clusters for MEIS3 Gene

Meis homeobox 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEIS3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEIS3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: - - -
SP3:
SP4:
SP5: - -

Relevant External Links for MEIS3 Gene

GeneLoc Exon Structure for
MEIS3
ECgene alternative splicing isoforms for
MEIS3

Expression for MEIS3 Gene

mRNA expression in normal human tissues for MEIS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEIS3 Gene

This gene is overexpressed in Brain - Amygdala (4.5), Uterus (4.4), Brain - Anterior cingulate cortex (BA24) (4.3), and Brain - Cortex (4.3).

SOURCE GeneReport for Unigene cluster for MEIS3 Gene Hs.380923

genes like me logo Genes that share expressions with MEIS3: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for MEIS3 Gene

Orthologs for MEIS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MEIS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEIS3 35
  • 98.97 (n)
  • 98.31 (a)
MEIS3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MEIS3 35
  • 90.64 (n)
  • 94.1 (a)
MEIS3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEIS3 35
  • 90.59 (n)
  • 94.09 (a)
MEIS3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Meis3 35
  • 86.76 (n)
  • 90.13 (a)
Meis3 16
Meis3 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 22 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Meis3 35
  • 87.11 (n)
  • 91.2 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 73 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC52546 35
zebrafish
(Danio rerio)
Actinopterygii meis3 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta hth 36
  • 42 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3310 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for MEIS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEIS3 Gene

ENSEMBL:
Gene Tree for MEIS3 (if available)
TreeFam:
Gene Tree for MEIS3 (if available)

Paralogs for MEIS3 Gene

Paralogs for MEIS3 Gene

Pseudogenes.org Pseudogenes for MEIS3 Gene

genes like me logo Genes that share paralogs with MEIS3: view

Variants for MEIS3 Gene

Sequence variations from dbSNP and Humsavar for MEIS3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs11622 -- 47,403,465(-) AGGCC(C/T)CTCCG utr-variant-3-prime
rs12620 -- 47,403,454(-) CTCAA(C/T)GCCTA utr-variant-3-prime
rs14163 -- 47,403,482(-) CAGGA(C/T)CCCAC utr-variant-3-prime
rs1054120 -- 47,403,406(-) GCCCA(C/T)CCAAG utr-variant-3-prime
rs1054126 -- 47,403,292(-) ATGGC(A/G)GCTAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MEIS3 Gene

Variant ID Type Subtype PubMed ID
dgv1107e1 CNV Complex 17122850
nsv428366 CNV Loss 18775914
nsv912201 CNV Loss 21882294
nsv9738 CNV Gain 18304495
nsv521341 CNV Gain 19592680
nsv517901 CNV Loss 19592680
esv2479786 CNV Loss 19546169

Relevant External Links for MEIS3 Gene

HapMap Linkage Disequilibrium report
MEIS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEIS3 Gene

Disorders for MEIS3 Gene

No disorders were found for MEIS3 Gene.

No data available for UniProtKB/Swiss-Prot for MEIS3 Gene

Publications for MEIS3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Identification of a new family of Pbx-related homeobox genes. (PMID: 8950991) Nakamura T. … Copeland N.G. (Oncogene 1996) 2 3
  3. Identification of a conserved family of Meis1-related homeobox genes. (PMID: 9049632) Steelman S. … Buchberg A.M. (Genome Res. 1997) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction. (PMID: 15617687) Williams T.M. … Innis J.W. (Dev. Biol. 2005) 3

Products for MEIS3 Gene

Sources for MEIS3 Gene

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