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Aliases for MEIS2 Gene

Aliases for MEIS2 Gene

  • Meis Homeobox 2 2 3 5
  • Meis1-Related Protein 1 3 4
  • MRG1 3 4
  • Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 2 (Mouse) 2
  • Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 2 3
  • TALE Homeobox Protein Meis2 3
  • Meis (Mouse) Homolog 2 2
  • Homeobox Protein Meis2 3
  • Meis1-Related Gene 1 3
  • Meis Homolog 2 3
  • HsT18361 3

External Ids for MEIS2 Gene

Previous GeneCards Identifiers for MEIS2 Gene

  • GC15M032527
  • GC15M030078
  • GC15M034762
  • GC15M034899
  • GC15M034970
  • GC15M037183
  • GC15M014029

Summaries for MEIS2 Gene

Entrez Gene Summary for MEIS2 Gene

  • This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MEIS2 Gene

MEIS2 (Meis Homeobox 2) is a Protein Coding gene. Diseases associated with MEIS2 include 15Q14 Microdeletion Syndrome and Learning Disability. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is MEIS1.

UniProtKB/Swiss-Prot for MEIS2 Gene

  • Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5-CGGTCA-3; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5-TGACAG-3in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription.

Gene Wiki entry for MEIS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEIS2 Gene

Genomics for MEIS2 Gene

Regulatory Elements for MEIS2 Gene

Enhancers for MEIS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F037092 1.7 FANTOM5 Ensembl ENCODE 9.7 -1.1 -1142 20.2 HDGF PKNOX1 ARNT WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 MEIS2 C15orf41 ENSG00000274444
GH15F036882 1.3 FANTOM5 Ensembl ENCODE 3.1 +218.0 218035 1.8 CTCF SUZ12 ZNF48 ZNF2 RAD21 GLIS2 PATZ1 ZNF143 SMC3 EZH2 MEIS2 C15orf41 LOC145845 ENSG00000212511
GH15F036915 0.7 FANTOM5 ENCODE 5.2 +186.1 186130 0.2 PKNOX1 RAD21 MEIS2 C15orf41 GC15P036887 MIR8063
GH15F037877 0.6 ENCODE 4.8 -777.0 -776994 1.1 JUND HLF FOS MAFK RAD21 TCF7L2 MEIS2 GC15P037868 TMCO5A
GH15F036960 0.6 FANTOM5 4.3 +140.3 140320 0.1 ARID1B OSR2 NR2F1 HMBOX1 NR2F6 MEIS2 MIR8063 GC15P036887
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MEIS2 on UCSC Golden Path with GeneCards custom track

Promoters for MEIS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001451299 1834 9000 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for MEIS2 Gene

Chromosome:
15
Start:
36,889,204 bp from pter
End:
37,101,334 bp from pter
Size:
212,131 bases
Orientation:
Minus strand

Genomic View for MEIS2 Gene

Genes around MEIS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEIS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEIS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEIS2 Gene

Proteins for MEIS2 Gene

  • Protein details for MEIS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14770-MEIS2_HUMAN
    Recommended name:
    Homeobox protein Meis2
    Protein Accession:
    O14770
    Secondary Accessions:
    • A6NJI5
    • A8MWD5
    • B3KP98
    • B3KPQ6
    • Q96DI2
    • Q96KI4
    • Q96KI5
    • Q9NRS1
    • Q9NRS2
    • Q9NRS3

    Protein attributes for MEIS2 Gene

    Size:
    477 amino acids
    Molecular mass:
    51790 Da
    Quaternary structure:
    • Isoform 2 interacts with TLX1. Isoform 3 interacts with HOXA13 and PBX1 isoform PBX1b. Isoform 4 interacts with SP1, SP3 and KLF4. Isoform 4 and isoform 5 interact with PBX1 isoform PBX1a; the interaction partially relieves MEIS2 autoinhibition. Isoform 3 also known as MEIS2b is part of a PDX1:PBX1b:Meis2B complex; Meis2B is recruited by PBX1b and can be replaced by isoform 4 in a small fraction of complexes. Can form trimeric complexes including HOXB8 and PBX2 or PBX3.

    Three dimensional structures from OCA and Proteopedia for MEIS2 Gene

    Alternative splice isoforms for MEIS2 Gene

neXtProt entry for MEIS2 Gene

Post-translational modifications for MEIS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MEIS2 (MEIS2)

No data available for DME Specific Peptides for MEIS2 Gene

Domains & Families for MEIS2 Gene

Gene Families for MEIS2 Gene

Protein Domains for MEIS2 Gene

Graphical View of Domain Structure for InterPro Entry

O14770

UniProtKB/Swiss-Prot:

MEIS2_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/MEIS homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the TALE/MEIS homeobox family.
genes like me logo Genes that share domains with MEIS2: view

Function for MEIS2 Gene

Molecular function for MEIS2 Gene

GENATLAS Biochemistry:
homeo domain protein,murine Meis1 (myeloid ecotropic viral integration site 1) ortholog,PBX1 related,expressed in hematopoietic tissues and brain,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors
UniProtKB/Swiss-Prot Function:
Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5-CGGTCA-3; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5-TGACAG-3in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription.

Gene Ontology (GO) - Molecular Function for MEIS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 10764806
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 10764806
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 10764806
GO:0003712 transcription cofactor activity ISS --
genes like me logo Genes that share ontologies with MEIS2: view

Phenotypes for MEIS2 Gene

genes like me logo Genes that share phenotypes with MEIS2: view

Human Phenotype Ontology for MEIS2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for MEIS2 Gene

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MEIS2 Gene

Localization for MEIS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEIS2 Gene

Nucleus. Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEIS2 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MEIS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with MEIS2: view

Pathways & Interactions for MEIS2 Gene

SuperPathways for MEIS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEIS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 10764806
GO:0001654 eye development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 10764806
genes like me logo Genes that share ontologies with MEIS2: view

No data available for Pathways by source and SIGNOR curated interactions for MEIS2 Gene

Drugs & Compounds for MEIS2 Gene

(1) Additional Compounds for MEIS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MEIS2: view

Transcripts for MEIS2 Gene

Unigene Clusters for MEIS2 Gene

Meis homeobox 2:
Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEIS2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - -
SP10: - - - - - -
SP11: - - - -
SP12: - -
SP13: - -
SP14: - - -
SP15: - -
SP16: -
SP17: - -
SP18: -
SP19:
SP20:
SP21:
SP22:

ExUns: 17a · 17b · 17c ^ 18a · 18b · 18c · 18d · 18e · 18f · 18g
SP1: -
SP2: -
SP3: -
SP4: -
SP5: - - -
SP6: - - -
SP7: -
SP8: -
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: - - -
SP18: - - -
SP19:
SP20:
SP21:
SP22: - - -

Relevant External Links for MEIS2 Gene

GeneLoc Exon Structure for
MEIS2
ECgene alternative splicing isoforms for
MEIS2

Expression for MEIS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MEIS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MEIS2 Gene

This gene is overexpressed in Fetal Brain (25.3), Ovary (13.1), Salivary gland (11.4), and Prostate (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MEIS2 Gene



Protein tissue co-expression partners for MEIS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MEIS2 Gene:

MEIS2

SOURCE GeneReport for Unigene cluster for MEIS2 Gene:

Hs.510989

mRNA Expression by UniProt/SwissProt for MEIS2 Gene:

O14770-MEIS2_HUMAN
Tissue specificity: Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic tissues. Also expressed in some regions of the brain, such as the putamen.
genes like me logo Genes that share expression patterns with MEIS2: view

No data available for mRNA differential expression in normal tissues for MEIS2 Gene

Orthologs for MEIS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MEIS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEIS2 34 35
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia MEIS2 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEIS2 34 35
  • 97.49 (n)
cow
(Bos Taurus)
Mammalia MEIS2 34 35
  • 97.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MEIS2 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Meis2 34 16 35
  • 95.46 (n)
rat
(Rattus norvegicus)
Mammalia Meis2 34
  • 95.11 (n)
chicken
(Gallus gallus)
Aves MEIS2 34 35
  • 91.3 (n)
lizard
(Anolis carolinensis)
Reptilia MEIS2 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia meis2 34
  • 81.05 (n)
zebrafish
(Danio rerio)
Actinopterygii MEIS2 (3 of 3) 35
  • 89 (a)
OneToMany
meis2b 35
  • 88 (a)
OneToMany
meis2a 34 35
  • 83.38 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta hth 35
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-62 36
  • 59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToMany
Species where no ortholog for MEIS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEIS2 Gene

ENSEMBL:
Gene Tree for MEIS2 (if available)
TreeFam:
Gene Tree for MEIS2 (if available)

Paralogs for MEIS2 Gene

Paralogs for MEIS2 Gene

genes like me logo Genes that share paralogs with MEIS2: view

Variants for MEIS2 Gene

Sequence variations from dbSNP and Humsavar for MEIS2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs879255264 Uncertain significance 36,896,664(-) AAGAA(-/GAA)TAGTA nc-transcript-variant, cds-indel
rs10152532 -- 37,055,573(+) AAATT(A/G)ATTCA intron-variant
rs10152841 -- 37,096,036(+) CCCCA(C/G/T)ATTAG intron-variant, utr-variant-5-prime
rs1020499 -- 36,962,634(+) CAGAC(A/G)TAAAG intron-variant
rs1037308 -- 36,970,482(-) TTGGC(A/G)CTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEIS2 Gene

Variant ID Type Subtype PubMed ID
nsv977862 CNV deletion 23825009
nsv952610 CNV deletion 24416366
nsv569200 CNV gain 21841781
nsv569199 CNV loss 21841781
nsv569198 CNV loss 21841781
nsv518513 CNV loss 19592680
nsv1496 CNV deletion 18451855
nsv1143779 CNV deletion 24896259
nsv1069852 CNV deletion 25765185
esv3636168 CNV loss 21293372
esv3636167 CNV loss 21293372
esv3636165 CNV gain 21293372
esv3636164 CNV gain 21293372
esv3636163 CNV gain 21293372
esv2749573 CNV deletion 23290073
esv2678174 CNV deletion 23128226
esv2676776 CNV deletion 23128226
esv2571731 CNV deletion 19546169

Variation tolerance for MEIS2 Gene

Residual Variation Intolerance Score: 21.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEIS2 Gene

Human Gene Mutation Database (HGMD)
MEIS2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEIS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEIS2 Gene

Disorders for MEIS2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MEIS2 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
15q14 microdeletion syndrome
  • del(15)(q14)
learning disability
  • academic skill disorder
axenfeld-rieger syndrome, type 3
  • anterior segment mesenchymal dysgenesis
- elite association - COSMIC cancer census association via MalaCards
Search MEIS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MEIS2

Genetic Association Database (GAD)
MEIS2
Human Genome Epidemiology (HuGE) Navigator
MEIS2
Tumor Gene Database (TGDB):
MEIS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEIS2
genes like me logo Genes that share disorders with MEIS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEIS2 Gene

Publications for MEIS2 Gene

  1. Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription. (PMID: 10764806) Yang Y. … Mouradian M.M. (J. Biol. Chem. 2000) 3 4 22 64
  2. Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene. (PMID: 9383298) Smith J.E. Jr. … Takeshita K. (Mamm. Genome 1997) 2 3 4 64
  3. Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. (PMID: 20195266) Adkins D.E. … van den Oord E.J. (Mol. Psychiatry 2011) 3 46 64
  4. Cooperative transcriptional activation by Klf4, Meis2, and Pbx1. (PMID: 21746878) Bjerke G.A. … Wotton D. (Mol. Cell. Biol. 2011) 3 4 64
  5. MEIS proteins as partners of the TLX1/HOX11 oncoprotein. (PMID: 19559479) Milech N. … Watt P.M. (Leuk. Res. 2010) 3 4 64

Products for MEIS2 Gene

Sources for MEIS2 Gene

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