MEIS2 Gene
protein-coding GIFtS : 59 GCID: GC15 M037183
Meis homeobox 2 Meis (mouse) homolog 2, Meis1, myeloid ecotropic viral...
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Aliasesfor MEIS2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Meis Homeobox 2 1 2 Homeobox Protein Meis22 MRG11 2 3 5 Meis Homolog 22 HsT183611 2 Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 22 Meis1-Related Protein 12 3 Meis1-Related Gene 12 Meis (Mouse) Homolog 21 TALE Homeobox Protein Meis22 Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 2 (Mouse)1
Export aliases for MEIS2 gene to outside databases Previous GC identifers: GC15M032527 GC15M030078 GC15M034762 GC15M034899 GC15M034970 GC15M014029
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Summariesfor MEIS2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MEIS2 : This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: MEIS2_HUMAN, O14770 Function : Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimerof PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3/Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3/Meis2B and isoform 4/Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5/Meis2E cannot activate DRD1 transcription Gene Wiki entry for MEIS2
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Genomic Viewsfor MEIS2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000015.9 NC_018926.1 NT_010194.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MEIS2 gene promoter:E2F-1 E2F E2F-2 Other transcription factors Search SABiosciences Chromatin IP Primers for MEIS2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 15q14 Ensembl cytogenetic band: 15q14 HGNC cytogenetic band: 15q14 MEIS2 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15M037183: view genomic region
(about GC identifiers )
Start: 37,181,409 bp from pter End:
37,393,504 bp from pter
Size: 212,096 bases Orientation:
minus strand
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Proteinsfor MEIS2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MEIS2_HUMAN, O14770 See
protein sequence )Recommended Name: Size : 477 amino acids; 51790 DaSubunit : Isoform 2/Meis2A interacts with TLX1. Isoform 3/Meis2B interacts with HOXA13 and PBX1 isoform PBX1b. Isoform4/Meis2D interacts with SP1, SP3 and KLF4. Isoform 4/Meis2D and isoform 5/Meis2E interact with PBX1 isoform PBX1a; the interaction partially relieves MEIS2 autoinhibition. Isoform 3/Meis2B is part of a PDX1:PBX1b:MEIS2b complex; Meis2B is recruited by PBX1b and can be replaced by isoform 4/Meis2D in a small fraction of complexes. Can form trimeric complexes including HOXB8 and PBX2 or PBX3
Subcellular location : Nucleus (By similarity)Developmental stage : Expressed in the proliferative zones of the fetal neocortex. Expressed at a very high level in thedeveloping ganglionic eminence and at a more moderate level in the cortical plate
1 PDB 3D structure from :3K2A (3D) Secondary accessions : A6NJI5 A8MWD5 B3KP98 B3KPQ6 Q96DI2 Q96KI4 Q96KI5 Q9NRS1 Q9NRS2 Q9NRS3Alternative splicing : 8 isoforms : O14770-1 O14770-2 O14770-3 O14770-4 O14770-5 O14770-6 O14770-7 O14770-8 (No experimental confirmation available) Explore the universe of human proteins at neXtProt for MEIS2: NX_O14770 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O14770 MEIS2 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (8 alternative transcripts): NP_001207411.1 NP_002390.1 NP_733774.1 NP_733775.1 NP_733776.1 NP_733777.1 NP_758526.1 NP_758527.1 ENSEMBL proteins: ENSP00000453793 ENSP00000341400 ENSP00000380749 ENSP00000326296 ENSP00000453390 ENSP00000453481 ENSP00000380745 ENSP00000404185 ENSP00000453497 ENSP00000452693 ENSP00000452874 ENSP00000452770 ENSP00000453782 ENSP00000372216 ENSP00000391887 ENSP00000339549 ENSP00000219869 Human Recombinant Protein Products for MEIS2: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
About GeneDecksing MEIS2 Antibody Products: Assay Products for MEIS2:
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Protein
Domains /for MEIS2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry O14770 ProtoNet protein and cluster: O14770
UniProtKB/Swiss-Prot: MEIS2_HUMAN, O14770 Similarity : Belongs to the TALE/MEIS homeobox familySimilarity : Contains 1 homeobox DNA-binding domain
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Functionfor MEIS2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: MEIS2_HUMAN, O14770 Function : Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimerof PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3/Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3/Meis2B and isoform 4/Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5/Meis2E cannot activate DRD1 transcription
Genatlas biochemistry entry for MEIS2 homeo domain protein,murine Meis1 (myeloid ecotropic viral integration site 1) ortholog,PBX1 related,expressed in hematopoietic tissues and brain,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7 ): About this table
About GeneDecksing Animal Models: Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 14 )human mouse rat see all 9 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 7 ): MEIS2 (NM_002399 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MEIS2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MEIS2
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEIS2
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Pathways & Interactionsfor MEIS2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MEIS2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)5/26 Interacting proteins for MEIS2 (O14770 1 , 2 , 3 ENSP00000326296 4 via UniProtKB, MINT, STRING , and/or I2D (see all 26 )About this table Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000122 negative regulation of transcription from RNA polymerase II promoter
TAS 10764806 GO:0001654 eye development
IEA -- GO:0006355 regulation of transcription, DNA-dependent
-- -- GO:0006366 transcription from RNA polymerase II promoter
TAS 10764806 GO:0009612 response to mechanical stimulus
-- --
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Drugs & Compoundsfor MEIS2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for MEIS2 1 Novoseek chemical compound relationship for MEIS2 gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
retinoic acid
37.2
4
15069081 (1), 10952894 (1)
MEIS2
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Transcriptsfor MEIS2 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MEIS2 gene (9 alternative transcripts): NM_001220482.1 NM_002399.3 NM_170674.4 NM_170675.4 NM_170676.4 NM_170677.4 NM_172315.2 NM_172316.2 NM_020149.2 Unigene Cluster for MEIS2:
Meis homeobox 2 Hs.510989 [show with all ESTs ] Unigene Representative Sequence: AK125465 18/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28 ): ENST00000561208 ENST00000338564 (uc001zjt.3 ) ENST00000397624 (uc001zjl.3 uc010ucj.2 uc001zjm.3 )ENST00000560702 (uc001zjj.3 uc001zjk.3 ) ENST00000314177 ENST00000559085 ENST00000560570 ENST00000397620 ENST00000424352 ENST00000559972 ENST00000561264 ENST00000561284 ENST00000559371 ENST00000557992 ENST00000558643 ENST00000559561 ENST00000559408 ENST00000561163 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 14 )human mouse rat see all 9 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 7 ): MEIS2 (NM_002399 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MEIS2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MEIS2
Additional cDNA sequence: AF017418.1 AF178948.1 AF179896.1 AF179897.1 AF179898.1 AK001298.1 AK055936.1 AK056038.1 AK056216.1 AK056620.1 AK125465.1 AK226072.1 AK294411.1 AK300247.1 AK311546.1 AY349358.1 BC001516.2 BC001844.2 BC007202.1 BC050431.1 NR_051953.1
24/28 DOTS entries (see all 28 ): DT.75169805 DT.447935
DT.91693692 DT.95182481 DT.100795878 DT.121049351 DT.91836087 DT.95182472 DT.86995473 DT.100795877 DT.97780902 DT.91762585 DT.100795881 DT.205564 DT.216393 DT.100795879 DT.100017039 DT.100736406 DT.121049185 DT.121049213 DT.121049300 DT.121049480 DT.121049481 DT.91762582 24/184 AceView cDNA sequences (see all 184 ):
CA389173 AW612481 BF510628 BM542564 AI702753 AW771662 BF592815 NM_020149 AF179898 NM_170676 NM_170674 NM_172316 AF178948 BQ631897 AF179896 BU735702 NM_172315 CD251460 BM717135 BC050431 NM_002399 AI681628 AK125465 NM_170675 GeneLoc Exon Structure 5/22 Alternative Splicing Database (ASD) splice patterns (SP) for MEIS2 (see all 22 ) About this scheme ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c ^ SP1 : - - - - - - - - - - - - SP2 : - - - - - - - - - SP3 : - - - - - - - - - - SP4 : - - - - - - - - - - SP5 : - - - - - - - - -
ExUns: 17a · 17b · 17c ^ 18a · 18b · 18c · 18d · 18e · 18f · 18g SP1 : - SP2 : - SP3 : - SP4 : - SP5 : - - -
ECgene alternative splicing isoforms for MEIS2
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Expression for MEIS2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MEIS2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: -- About this image MEIS2 expression in embryonic tissues and stem cells About this table
See MEIS2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MEIS2 SOURCE GeneReport for Unigene cluster: Hs.510989 UniProtKB/Swiss-Prot: MEIS2_HUMAN, O14770 Tissue specificity : Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietictissues. Also expressed in some regions of the brain, such as the putamen SABiosciences Expression via Pathway-Focused PCR Arrays including MEIS2 : Polycomb & Trithorax Target Genes in human mouse rat Homeobox (HOX) Genes in human mouse rat
Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEIS2
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Orthologsfor MEIS2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for MEIS2 gene from 7/22 species (see all 22 ) About this table
ENSEMBL Gene Tree for MEIS2 (if available)TreeFam Gene Tree for MEIS2 (if available)
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Paralogsfor MEIS2 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MEIS2 gene TGIF2LY 2 PKNOX1 2 MEIS3 2 TGIF2 2 PKNOX2 2 TGIF2LX 2 TGIF1 2 MEIS1 2 11 SIMAP similar genes for MEIS2 using alignment to 7 protein entries: MEIS2_HUMAN (see all proteins ):HB103 meis1 MEIS1 MEIS3 MEIS3P1 TGIF1 MEIS3P2 PKNOX1 TGIF2LY PKNOX2 WUGSC About GeneDecksing
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Genomic Variantsfor MEIS2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 15 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for MEIS2 (37181409 - 37393504 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for MEIS2 1 CNV 102080 Human Gene Mutation Database (HGMD) : MEIS2 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor MEIS2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 601740
OMIM disorders : --10 : About MalaCards attention deficit hyperactivity disorder acute myeloid leukemia myeloid leukemia embryonal carcinoma ovarian cancer leukemia neuroblastoma carcinoma pancreatitis neuronitis Human Genome Epidemiology (HuGE) Navigator: MEIS2 (7 documents) Tumor Gene Database (TGDB) : MEIS2 Export disorders for MEIS2 gene to outside databases
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Publicationsfor MEIS2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MEIS2 gene, integrated from 9 sources (see all 46 ):(articles sorted by number of sources associating them with MEIS2) Utopia : connect your pdf to the dynamic
Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene. (PubMed id 9383298) 1 , 2 , 3(1997) Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription. (PubMed id 10764806) 1 , 2 , 9(2000) Cooperative transcriptional activation by Klf4, Meis2 , and Pbx1. (PubMed id 21746878) 1 , 2 (2011) MEIS proteins as partners of the TLX1/HOX11 oncoprote in. (PubMed id 19559479) 1 , 2 (2010) An autoinhibitory effect of the homothorax domain of Meis2. (PubMed id 20553494) 1 , 2 (2010) Spatiotemporal distribution of PAX6 and MEIS2 express ion and total cell numbers in the ganglionic eminence in the early developing h uman forebrain. (PubMed id 20523026) 1 , 2 (2010) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex. (PubMed id 11279116) 1 , 2 (2001) Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin. (PubMed id 10619030) 1 , 9(1999)
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About This Section Patent Information for MEIS2 gene: MEIS2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MEIS2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for MEIS2 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for MEIS2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MEIS2 OriGene 3'-UTR Clone for MEIS2 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for MEIS2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MEIS2 OriGene Custom Protein Services for MEIS2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MEIS2 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEIS2
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MEIS2
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