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Aliases for MEIS2 Gene

Aliases for MEIS2 Gene

  • Meis Homeobox 2 2 3
  • Meis1-Related Protein 1 3 4
  • MRG1 3 4
  • Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 2 (Mouse) 2
  • Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 2 3
  • TALE Homeobox Protein Meis2 3
  • Meis (Mouse) Homolog 2 2
  • Meis1-Related Gene 1 3
  • Meis Homolog 2 3
  • HsT18361 3

External Ids for MEIS2 Gene

Previous GeneCards Identifiers for MEIS2 Gene

  • GC15M032527
  • GC15M030078
  • GC15M034762
  • GC15M034899
  • GC15M034970
  • GC15M037183
  • GC15M014029

Summaries for MEIS2 Gene

Entrez Gene Summary for MEIS2 Gene

  • This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MEIS2 Gene

MEIS2 (Meis Homeobox 2) is a Protein Coding gene. Diseases associated with MEIS2 include 15q14 microdeletion syndrome and learning disability. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is TGIF2LY.

UniProtKB/Swiss-Prot for MEIS2 Gene

  • Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3/Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3/Meis2B and isoform 4/Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5-CGGTCA-3; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5-TGACAG-3in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5/Meis2E cannot activate DRD1 transcription.

Gene Wiki entry for MEIS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEIS2 Gene

Genomics for MEIS2 Gene

Regulatory Elements for MEIS2 Gene

Transcription factor binding sites by QIAGEN in the MEIS2 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MEIS2 Gene

Chromosome:
15
Start:
36,889,204 bp from pter
End:
37,101,334 bp from pter
Size:
212,131 bases
Orientation:
Minus strand

Genomic View for MEIS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEIS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEIS2 Gene

Proteins for MEIS2 Gene

  • Protein details for MEIS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14770-MEIS2_HUMAN
    Recommended name:
    Homeobox protein Meis2
    Protein Accession:
    O14770
    Secondary Accessions:
    • A6NJI5
    • A8MWD5
    • B3KP98
    • B3KPQ6
    • Q96DI2
    • Q96KI4
    • Q96KI5
    • Q9NRS1
    • Q9NRS2
    • Q9NRS3

    Protein attributes for MEIS2 Gene

    Size:
    477 amino acids
    Molecular mass:
    51790 Da
    Quaternary structure:
    • Isoform 2/Meis2A interacts with TLX1. Isoform 3/Meis2B interacts with HOXA13 and PBX1 isoform PBX1b. Isoform 4/Meis2D interacts with SP1, SP3 and KLF4. Isoform 4/Meis2D and isoform 5/Meis2E interact with PBX1 isoform PBX1a; the interaction partially relieves MEIS2 autoinhibition. Isoform 3/Meis2B is part of a PDX1:PBX1b:MEIS2b complex; Meis2B is recruited by PBX1b and can be replaced by isoform 4/Meis2D in a small fraction of complexes. Can form trimeric complexes including HOXB8 and PBX2 or PBX3.

    Three dimensional structures from OCA and Proteopedia for MEIS2 Gene

    Alternative splice isoforms for MEIS2 Gene

neXtProt entry for MEIS2 Gene

Proteomics data for MEIS2 Gene at MOPED

Post-translational modifications for MEIS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MEIS2 (Meis2)

No data available for DME Specific Peptides for MEIS2 Gene

Domains & Families for MEIS2 Gene

Gene Families for MEIS2 Gene

Protein Domains for MEIS2 Gene

Graphical View of Domain Structure for InterPro Entry

O14770

UniProtKB/Swiss-Prot:

MEIS2_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/MEIS homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the TALE/MEIS homeobox family.
genes like me logo Genes that share domains with MEIS2: view

Function for MEIS2 Gene

Molecular function for MEIS2 Gene

GENATLAS Biochemistry:
homeo domain protein,murine Meis1 (myeloid ecotropic viral integration site 1) ortholog,PBX1 related,expressed in hematopoietic tissues and brain,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors
UniProtKB/Swiss-Prot Function:
Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3/Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3/Meis2B and isoform 4/Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5-CGGTCA-3; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5-TGACAG-3in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5/Meis2E cannot activate DRD1 transcription.

Gene Ontology (GO) - Molecular Function for MEIS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 10764806
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 10764806
GO:0003677 DNA binding --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 10764806
GO:0003712 transcription cofactor activity ISS --
genes like me logo Genes that share ontologies with MEIS2: view

Animal Model Products

miRNA for MEIS2 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEIS2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for MEIS2 Gene

Localization for MEIS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEIS2 Gene

Nucleus. Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEIS2 Gene COMPARTMENTS Subcellular localization image for MEIS2 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for MEIS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with MEIS2: view

Pathways & Interactions for MEIS2 Gene

SuperPathways for MEIS2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Homeobox (HOX) Genes in human,mouse,rat
    • Polycomb & Trithorax Target Genes in human,mouse,rat

Gene Ontology (GO) - Biological Process for MEIS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 10764806
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter TAS 10764806
GO:0007275 multicellular organismal development IEA --
GO:0045638 negative regulation of myeloid cell differentiation ISS --
genes like me logo Genes that share ontologies with MEIS2: view

No data available for Pathways by source and SIGNOR curated interactions for MEIS2 Gene

Drugs & Compounds for MEIS2 Gene

(1) Additional Compounds for MEIS2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
retinoic acid
302-79-4
genes like me logo Genes that share compounds with MEIS2: view

Transcripts for MEIS2 Gene

Unigene Clusters for MEIS2 Gene

Meis homeobox 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEIS2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEIS2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - -
SP10: - - - - - -
SP11: - - - -
SP12: - -
SP13: - -
SP14: - - -
SP15: - -
SP16: -
SP17: - -
SP18: -
SP19:
SP20:
SP21:
SP22:

ExUns: 17a · 17b · 17c ^ 18a · 18b · 18c · 18d · 18e · 18f · 18g
SP1: -
SP2: -
SP3: -
SP4: -
SP5: - - -
SP6: - - -
SP7: -
SP8: -
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: - - -
SP18: - - -
SP19:
SP20:
SP21:
SP22: - - -

Relevant External Links for MEIS2 Gene

GeneLoc Exon Structure for
MEIS2
ECgene alternative splicing isoforms for
MEIS2

Expression for MEIS2 Gene

mRNA expression in normal human tissues for MEIS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MEIS2 Gene

This gene is overexpressed in Fetal Brain (25.3), Ovary (13.1), Salivary gland (11.4), and Prostate (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MEIS2 Gene



SOURCE GeneReport for Unigene cluster for MEIS2 Gene Hs.510989

mRNA Expression by UniProt/SwissProt for MEIS2 Gene

O14770-MEIS2_HUMAN
Tissue specificity: Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic tissues. Also expressed in some regions of the brain, such as the putamen
genes like me logo Genes that share expression patterns with MEIS2: view

Protein tissue co-expression partners for MEIS2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MEIS2 Gene

Orthologs for MEIS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MEIS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MEIS2 35
  • 97.06 (n)
  • 99.37 (a)
MEIS2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEIS2 35
  • 97.49 (n)
  • 99.57 (a)
MEIS2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Meis2 35
  • 95.46 (n)
  • 99.58 (a)
Meis2 16
Meis2 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MEIS2 35
  • 100 (n)
  • 100 (a)
MEIS2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Meis2 35
  • 95.11 (n)
  • 99.36 (a)
oppossum
(Monodelphis domestica)
Mammalia MEIS2 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEIS2 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves MEIS2 35
  • 91.3 (n)
  • 99.48 (a)
MEIS2 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEIS2 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia meis2 35
  • 81.05 (n)
  • 97.71 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
meis2a 35
  • 83.38 (n)
  • 97.1 (a)
MEIS2 (3 of 3) 36
  • 89 (a)
OneToMany
meis2a 36
  • 95 (a)
OneToMany
meis2b 36
  • 88 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta hth 36
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-62 37
  • 59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for MEIS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEIS2 Gene

ENSEMBL:
Gene Tree for MEIS2 (if available)
TreeFam:
Gene Tree for MEIS2 (if available)

Paralogs for MEIS2 Gene

Paralogs for MEIS2 Gene

genes like me logo Genes that share paralogs with MEIS2: view

Variants for MEIS2 Gene

Sequence variations from dbSNP and Humsavar for MEIS2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs3684 -- 36,894,471(+) CACAG(C/T)AAATA intron-variant
rs698455 -- 36,937,115(+) GAGGT(G/T)GGATA intron-variant
rs698456 -- 36,937,035(+) CAAGC(A/C)ACCCA intron-variant
rs716218 -- 36,899,760(+) AAAAG(A/G/T)TTCCA intron-variant
rs837127 -- 36,951,985(+) ATGAG(G/T)CTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEIS2 Gene

Variant ID Type Subtype PubMed ID
nsv904079 CNV Loss 21882294
esv2571731 CNV Deletion 19546169
nsv518513 CNV Loss 19592680
esv2678174 CNV Deletion 23128226
esv2749573 CNV Deletion 23290073
nsv1496 CNV Loss 18451855
esv2676776 CNV Deletion 23128226

Variation tolerance for MEIS2 Gene

Residual Variation Intolerance Score: 21.06% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEIS2 Gene

HapMap Linkage Disequilibrium report
MEIS2
Human Gene Mutation Database (HGMD)
MEIS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEIS2 Gene

Disorders for MEIS2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MEIS2 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
15q14 microdeletion syndrome
  • del(15)(q14)
learning disability
  • learning disorder
axenfeld-rieger syndrome, type 3
  • rieger or axenfeld anomalies
- elite association
Search MEIS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MEIS2

Genetic Association Database (GAD)
MEIS2
Human Genome Epidemiology (HuGE) Navigator
MEIS2
Tumor Gene Database (TGDB):
MEIS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEIS2
genes like me logo Genes that share disorders with MEIS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEIS2 Gene

Publications for MEIS2 Gene

  1. Evidence against involvement of Bmp receptor 1b signaling in fate specification of the chick mesencephalic alar plate at HH16. (PMID: 19539011) Bobak N. … Schulte D. (Neurosci. Lett. 2009) 23 67
  2. Meis2 competes with the Groucho co-repressor Tle4 for binding to Otx2 and specifies tectal fate without induction of a secondary midbrain-hindbrain boundary organizer. (PMID: 19736326) Agoston Z. … Schulte D. (Development 2009) 23 67
  3. Differential and dose-dependent regulation of gene expression at the mid-hindbrain boundary by Ras-MAP kinase signaling. (PMID: 18343356) Vennemann A. … Schulte D. (Brain Res. 2008) 23 67
  4. Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors. (PMID: 18787068) Wassef M.A. … Ghislain J. (Development 2008) 23 67
  5. Molecular identity of olfactory bulb interneurons: transcriptional codes of periglomerular neuron subtypes. (PMID: 17624499) Allen Z.J. … Campbell K. (J. Mol. Histol. 2007) 23 67

Products for MEIS2 Gene

Sources for MEIS2 Gene

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