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MEIS2 Gene

protein-coding   GIFtS: 59
GCID: GC15M037183

Meis Homeobox 2

(Previous names: Meis (mouse) homolog 2, Meis1, myeloid ecotropic viral integration...)
  See MEIS2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Meis Homeobox 21 2     Homeobox Protein Meis22
MRG12 3 5     Meis Homolog 22
Meis1-Related Protein 12 3     Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 22
Meis (Mouse) Homolog 21     Meis1-Related Gene 12
Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 2 (Mouse)1     TALE Homeobox Protein Meis22
HsT183612     

External Ids:    HGNC: 70011   Entrez Gene: 42122   Ensembl: ENSG000001341387   OMIM: 6017405   UniProtKB: O147703   

Export aliases for MEIS2 gene to outside databases

Previous GC identifers: GC15M032527 GC15M030078 GC15M034762 GC15M034899 GC15M034970 GC15M014029


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MEIS2 Gene:
This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of
homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and
several members have been shown to be essential contributors to developmental programs. Multiple transcript
variants encoding distinct isoforms have been described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MEIS2 Gene:
MEIS2 (Meis homeobox 2) is a protein-coding gene. Diseases associated with MEIS2 include 15q14 microdeletion syndrome. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TGIF2LY.

UniProtKB/Swiss-Prot: MEIS2_HUMAN, O14770
Function: Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound
dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex.
Isoform 3/Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved
in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and
cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved
in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform
3/Meis2B and isoform 4/Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in
cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of
EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA
sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate
DRD1 transcription; isoform 5/Meis2E cannot activate DRD1 transcription

Gene Wiki entry for MEIS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MEIS2 gene promoter:
         E2F-1   E2F   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MEIS2 promoter sequence
   Search Chromatin IP Primers for MEIS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEIS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q14   Ensembl cytogenetic band:  15q14   HGNC cytogenetic band: 15q14

MEIS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEIS2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M037183:  view genomic region     (about GC identifiers)

Start:
37,181,406 bp from pter      End:
37,393,504 bp from pter
Size:
212,099 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MEIS2_HUMAN, O14770 (See protein sequence)
Recommended Name: Homeobox protein Meis2  
Size: 477 amino acids; 51790 Da
Subunit: Isoform 2/Meis2A interacts with TLX1. Isoform 3/Meis2B interacts with HOXA13 and PBX1 isoform PBX1b.
Isoform 4/Meis2D interacts with SP1, SP3 and KLF4. Isoform 4/Meis2D and isoform 5/Meis2E interact with PBX1
isoform PBX1a; the interaction partially relieves MEIS2 autoinhibition. Isoform 3/Meis2B is part of a
PDX1:PBX1b:MEIS2b complex; Meis2B is recruited by PBX1b and can be replaced by isoform 4/Meis2D in a small
fraction of complexes. Can form trimeric complexes including HOXB8 and PBX2 or PBX3
Developmental stage: Expressed in the proliferative zones of the fetal neocortex. Expressed at a very high level
in the developing ganglionic eminence and at a more moderate level in the cortical plate
1 PDB 3D structure from and Proteopedia for MEIS2:
3K2A (3D)    
Secondary accessions: A6NJI5 A8MWD5 B3KP98 B3KPQ6 Q96DI2 Q96KI4 Q96KI5 Q9NRS1 Q9NRS2 Q9NRS3
Alternative splicing: 8 isoforms:  O14770-1   O14770-2   O14770-3   O14770-4   O14770-5   O14770-6   O14770-7   O14770-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MEIS2: NX_O14770

Explore proteomics data for MEIS2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MEIS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001207411.1  NP_002390.1  NP_733774.1  NP_733775.1  NP_733776.1  NP_733777.1  NP_758526.1  NP_758527.1  

    ENSEMBL proteins: 
     ENSP00000341400   ENSP00000453793   ENSP00000380749   ENSP00000326296   ENSP00000453390  
     ENSP00000453481   ENSP00000452693   ENSP00000380745   ENSP00000404185   ENSP00000453497  
     ENSP00000475899   ENSP00000475660   ENSP00000452874   ENSP00000452770   ENSP00000453782  
     ENSP00000372216   ENSP00000391887   ENSP00000339549   ENSP00000219869  

    MEIS2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for MEIS2
    OriGene Protein Over-expression Lysate for MEIS2
    OriGene MassSpec for MEIS2
    OriGene Custom Protein Services for MEIS2
    GenScript Custom Purified and Recombinant Proteins Services for MEIS2
    Novus Biologicals MEIS2 Protein
    Novus Biologicals MEIS2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MEIS2

     
    Search eBioscience for Proteins for MEIS2 

    MEIS2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MEIS2
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MEIS2
    OriGene Custom Antibody Services for MEIS2
    Novus Biologicals MEIS2 Antibodies
    Abcam antibodies for MEIS2
    Cloud-Clone Corp. Antibodies for MEIS2
    ThermoFisher Antibody for MEIS2
    LSBio Antibodies in human, mouse, rat for MEIS2

    MEIS2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MEIS2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MEIS2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MEIS2
    Cloud-Clone Corp. CLIAs for MEIS2
    Search eBioscience for ELISAs for MEIS2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TALE: Homeoboxes / TALE class

    3 InterPro protein domains:
     IPR008422 Homeobox_KN_domain
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry O14770

    ProtoNet protein and cluster: O14770

    UniProtKB/Swiss-Prot: MEIS2_HUMAN, O14770
    Similarity: Belongs to the TALE/MEIS homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with MEIS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MEIS2_HUMAN, O14770
    Function: Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound
    dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex.
    Isoform 3/Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved
    in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and
    cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved
    in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform
    3/Meis2B and isoform 4/Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in
    cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of
    EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA
    sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate
    DRD1 transcription; isoform 5/Meis2E cannot activate DRD1 transcription

         Genatlas biochemistry entry for MEIS2:
    homeo domain protein,murine Meis1 (myeloid ecotropic viral integration site 1) ortholog,PBX1 related,expressed in
    hematopoietic tissues and brain,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003712transcription cofactor activity ISS--
    GO:0003714transcription corepressor activity TAS10764806
    GO:0005515protein binding IPI19559479
         
    Find genes that share ontologies with MEIS2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MEIS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MEIS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MEIS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MEIS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target MEIS2:
    hsa-mir-204-5p (MIRT003546), hsa-mir-192-5p (MIRT026864), hsa-mir-215-5p (MIRT024859)

    Block miRNA regulation of human, mouse, rat MEIS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MEIS2 (see all 120):
    hsa-miR-548j hsa-miR-300 hsa-miR-199a-3p hsa-miR-134 hsa-miR-128 hsa-miR-485-3p hsa-miR-30d hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidMEIS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MEIS2
    Predesigned siRNA for gene silencing in human, mouse, rat MEIS2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MEIS2

    Clone
    Products:
         
    OriGene clones in human, mouse for MEIS2 (see all 45)
    OriGene ORF clones in mouse, rat for MEIS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): MEIS2 (NM_002399)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEIS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEIS2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MEIS2
    Browse ESI BIO Cell Lines and PureStem Progenitors for MEIS2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEIS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MEIS2_HUMAN, O14770: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with MEIS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including MEIS2: 
              Polycomb & Trithorax Target Genes in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MEIS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MEIS2 (O147701, 2, 3 ENSP000003262964) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PBX1P404241, 2, 3, ENSP000004058904EBI-8025850,EBI-301611 MINT-7718083 MINT-7718330 MINT-7718353 MINT-7718110 MINT-7718300 MINT-7718256 MINT-7718172 I2D: score=2 STRING: ENSP00000405890
    ENSG00000224952P404253, ENSP000003917454I2D: score=3 STRING: ENSP00000391745
    ENSG00000225987P404253, ENSP000004039484I2D: score=3 STRING: ENSP00000403948
    ENSG00000232005P404253, ENSP000003900094I2D: score=3 STRING: ENSP00000390009
    ENSG00000236353P404253, ENSP000004107104I2D: score=3 STRING: ENSP00000410710
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS10764806
    GO:0001654eye development IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS10764806
    GO:0009612response to mechanical stimulus IEA--

    Find genes that share ontologies with MEIS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MEIS2

    1 Novoseek inferred chemical compound relationship for MEIS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 37.2 4 15069081 (1), 10952894 (1)



    Find genes that share compounds with MEIS2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MEIS2 gene (9 alternative transcripts): 
    NM_001220482.1  NM_002399.3  NM_170674.4  NM_170675.4  NM_170676.4  NM_170677.4  NM_172315.2  NM_172316.2  
    NM_020149.2  

    Unigene Cluster for MEIS2:

    Meis homeobox 2
    Hs.510989  [show with all ESTs]
    Unigene Representative Sequence: AK125465
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000338564(uc001zjt.3) ENST00000561208 ENST00000397624(uc001zjl.3 uc010ucj.2 uc001zjm.3)
    ENST00000560702(uc001zjj.3 uc001zjk.3) ENST00000314177 ENST00000559085
    ENST00000560570 ENST00000557796 ENST00000397620 ENST00000424352 ENST00000559972
    ENST00000561264 ENST00000561284 ENST00000559371 ENST00000557992 ENST00000558643
    ENST00000559561 ENST00000559408
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MEIS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MEIS2 (see all 120):
    hsa-miR-548j hsa-miR-300 hsa-miR-199a-3p hsa-miR-134 hsa-miR-128 hsa-miR-485-3p hsa-miR-30d hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidMEIS2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MEIS2
    Predesigned siRNA for gene silencing in human, mouse, rat MEIS2
    Clone
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    OriGene clones in human, mouse for MEIS2 (see all 45)
    OriGene ORF clones in mouse, rat for MEIS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): MEIS2 (NM_002399)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEIS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEIS2
    Primer
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    OriGene qPCR primer pairs and template standards for MEIS2
    OriGene qSTAR qPCR primer pairs in human, mouse for MEIS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MEIS2
      QuantiTect SYBR Green Assays in human, mouse, rat MEIS2
      QuantiFast Probe-based Assays in human, mouse, rat MEIS2

    Additional mRNA sequence: 

    AF017418.1 AF178948.1 AF179896.1 AF179897.1 AF179898.1 AK001298.1 AK055936.1 AK056038.1 
    AK056216.1 AK056620.1 AK125465.1 AK226072.1 AK294411.1 AK300247.1 AK311546.1 AY349358.1 
    BC001516.2 BC001844.2 BC007202.1 BC050431.1 NR_051953.1 

    Selected DOTS entries (see all 28):

    DT.75169805  DT.447935  DT.91693692  DT.95182481  DT.100795878  DT.121049351  DT.91836087  DT.95182472 
    DT.86995473  DT.100795877  DT.97780902  DT.91762585  DT.100795881  DT.205564  DT.216393  DT.100795879 
    DT.100017039  DT.100736406  DT.121049185  DT.121049213  DT.121049300  DT.121049480  DT.121049481  DT.91762582 

    Selected AceView cDNA sequences (see all 184):

    BF592815 BM717135 NM_020149 AF178948 BQ631897 NM_170676 BM679305 BC050431 
    AF179898 NM_172316 AW612481 NM_170674 BU735702 AF179896 CD251460 AI681628 
    AI702753 BM542564 AK056038 NM_170677 AF179899 NM_170675 AI365121 CA396012 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MEIS2 (see all 22)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c ^
    SP1:              -     -     -           -                 -                 -                                   -     -     -     -           -     -         
    SP2:                          -           -                 -                 -                                   -     -     -     -           -               
    SP3:                          -           -                 -                 -                                   -     -     -     -           -     -         
    SP4:                                      -     -           -                 -                                   -     -     -     -           -     -         
    SP5:                          -           -                 -                 -                                   -     -     -     -           -               

    ExUns: 17a · 17b · 17c ^ 18a · 18b · 18c · 18d · 18e · 18f · 18g
    SP1:              -                                             
    SP2:              -                                             
    SP3:              -                                             
    SP4:              -                                             
    SP5:  -     -     -                                             


    ECgene alternative splicing isoforms for MEIS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MEIS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MEIS2 Expression
    About this image


    MEIS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 24) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Endothelial Cells Blood Brain Barrier
             Thalamus
             Forebrain GABA neurons
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Prechondrocytic Mesenchymal Cells Stylopod
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Prechondrocytic Mesenchymal Cells Stylopod
             Bone Marrow
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Telencephalon
             Lateral Ganglionic Eminence progenitors
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Prechondrocytic Mesenchymal Cells Stylopod
    MEIS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MEIS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.510989

    UniProtKB/Swiss-Prot: MEIS2_HUMAN, O14770
    Tissue specificity: Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic
    tissues. Also expressed in some regions of the brain, such as the putamen

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MEIS2: 
              Polycomb & Trithorax Target Genes in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MEIS2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Meis21 , 5 Meis homeobox 21, 5 95.46(n)1
    99.58(a)1
      2 (58.28 cM)5
    175361  NM_001159568.11  NP_001153040.11 
     1158630645 
    chicken
    (Gallus gallus)
    Aves MEIS21 Meis homeobox 2 91.3(n)
    99.48(a)
      395588  NM_204803.1  NP_990134.1 
    lizard
    (Anolis carolinensis)
    Reptilia MEIS26
    Meis homeobox 2
    90(a)
    1 ↔ 1
    1(31742989-31973272)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia meis21 Meis homeobox 2 81.05(n)
    97.71(a)
      100036664  NM_001097218.1  NP_001090687.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056515.12   -- 87.86(n)   170454  BC056515.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta hth6
    homothorax
    49(a)
    1 → many
    3R(6335569-6464386)


    ENSEMBL Gene Tree for MEIS2 (if available)
    TreeFam Gene Tree for MEIS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MEIS2 gene
    TGIF2LY2  PKNOX12  MEIS32  TGIF22  PKNOX22  TGIF2LX2  MEIS12  TGIF12  
    12 SIMAP similar genes for MEIS2 using alignment to 8 protein entries:     MEIS2_HUMAN (see all proteins):
    HB103    meis1    MEIS1    MEIS3    MEIS3P1    MEIS3P2
    TGIF1    TGIF2LY    PKNOX1    PKNOX2    TGIF2    WUGSC

    Find genes that share paralogs with MEIS2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MEIS2 (see all 3881)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1459629821,2
    C--14040812(+) GCTGC-/AAAAAA 9 -- int10--------
    rs1417811511,2
    C--14042730(+) TTCTT-/CTTTTT 9 -- int10--------
    rs718352001,2
    C--14049364(+) TAACG-/GT    
       
    /GTGT
    TGTGT
    9 -- int10--------
    rs359820321,2
    C--14050144(+) GGGGGG/-ATAAA 9 -- int11Minor allele frequency- -:0.50NA 2
    rs2016442311,2
    --14065818(+) TCTCT-/CTGGGA 9 -- int10--------
    rs765416391,2
    C,F--14073283(+) TTTTTC/TTTTTT 9 -- int12Minor allele frequency- T:0.50NA 4
    rs113113491,2
    C--14074376(+) CTCCCG/-GGGTT 9 -- int11Minor allele frequency- -:0.00NA 2
    rs595896621,2
    C--14090688(+) TGTCT-/GTCT/GTCT
    CT
    /GTCTCTCT
    CTCTC
    17 -- int1 cds10--------
    rs789450591,2
    C--14104981(+) CTAGGA/GAGGCA 9 -- int10--------
    rs357193781,2
    C--14108493(+) AAAAAA/-GTGCA 9 -- int11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for MEIS2 (37181406 - 37393504 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MEIS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2571731CNV Deletion19546169
    esv2676776CNV Deletion23128226
    esv2749573CNV Deletion23290073
    esv2678174CNV Deletion23128226
    nsv904079CNV Loss21882294
    nsv1496CNV Loss18451855
    nsv518513CNV Loss19592680

    Human Gene Mutation Database (HGMD): MEIS2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MEIS2
    DNA2.0 Custom Variant and Variant Library Synthesis for MEIS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601740    OMIM disorders: --

    1 disease for MEIS2:    
    About MalaCards
    15q14 microdeletion syndrome


    Find genes that share disorders with MEIS2           About GenesLikeMe

    Genetic Association Database (GAD): MEIS2
    Human Genome Epidemiology (HuGE) Navigator: MEIS2 (7 documents)
    Tumor Gene Database (TGDB): MEIS2

    Export disorders for MEIS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MEIS2 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with MEIS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene. (PubMed id 9383298)1, 2, 3 Smith J.E. Jr.... Takeshita K. (Mamm. Genome 1997)
    2. Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription. (PubMed id 10764806)1, 2, 9 Yang Y.... Mouradian M.M. (J. Biol. Chem. 2000)
    3. Cooperative transcriptional activation by Klf4, Meis2, and Pbx1. (PubMed id 21746878)1, 2 Bjerke G.A.... Wotton D. (Mol. Cell. Biol. 2011)
    4. Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. (PubMed id 20195266)1, 4 Adkins D.E....van den Oord E.J. (Mol. Psychiatry 2011)
    5. MEIS proteins as partners of the TLX1/HOX11 oncoprotein. (PubMed id 19559479)1, 2 Milech N....Watt P.M. (Leuk. Res. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. An autoinhibitory effect of the homothorax domain of Meis2. (PubMed id 20553494)1, 2 Hyman-Walsh C.... Wotton D. (FEBS J. 2010)
    8. Spatiotemporal distribution of PAX6 and MEIS2 expression and total cell numbers in the ganglionic eminence in the early developing human forebrain. (PubMed id 20523026)1, 2 Larsen K.B.... Moller M. (Dev. Neurosci. 2010)
    9. Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. (PubMed id 19584346)1, 4 Vasan R.S....Blankenberg S. (JAMA 2009)
    10. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PubMed id 18821565)1, 4 Lasky-Su J....Faraone S.V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4212 HGNC: 7001 AceView: MEIS2 Ensembl:ENSG00000134138 euGenes: HUgn4212
    ECgene: MEIS2 H-InvDB: MEIS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MEIS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MEIS2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MEIS2 gene:
    Search GeneIP for patents involving MEIS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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