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MEIS1 Gene

protein-coding GIFtS: 59

GC02P066574

Meis homeobox 1
(Previous names: Meis1 (mouse) homolog, Meis1, myeloid ecotropic viral integration site 1 homolog (mouse) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC43380 ^²
WUGSC:H_NH0444B04.1 ^²

Descriptions
Meis homeobox 1 ^²
Meis1 (mouse) homolog ^¹
Meis1, myeloid ecotropic viral integration site 1 homolog ^²
Meis1, myeloid ecotropic viral integration site 1 homolog (mouse) ^¹
leukemogenic homolog protein ^²

External Ids
HGNC: 7000¹
Entrez Gene: 4211²
UniProtKB: O00470³
Ensembl: ENSG00000143995⁷

Search outside databases for aliases for MEIS1 gene

Previous GC identifers: GC02P066796 GC02P066620 GC02P066637

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MEIS1:

Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play

a crucial role in normal development. In addition, several homeoproteins are involved in

neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop

extension') family of homeodomain-containing proteins. [provided by RefSeq]

UniProtKB/Swiss-Prot: MEIS1_HUMAN, O00470

Function: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4

in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and

vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid

leukemias

Gene Wiki entry for MEIS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MEIS1 gene

Entrez Gene cytogenetic band: 2p14-p13 Ensembl cytogenetic band: 2p14 HGNC cytogenetic band: 2p14

MEIS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P066574: (about GC identifiers)

Start:	66,516,036 bp from pter
End:	66,653,395 bp from pter
Size:	137,360 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_022184.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MEIS1_HUMAN, O00470 (See protein sequence)

Recommended Name: Homeobox protein Meis1

Size: 390 amino acids; 43016 Da

Subunit: Interacts with the N-terminal region of PBX1 to form a heterodimer which binds DNA

including a cAMP-responsive sequence in CYP17. Also forms heterodimers with PBX2. Forms

heterotrimers with PBX1 or PBX2 and a number of HOX proteins including HOXA9, HOXD4 and HOXD9

where it acts as a non-DNA-binding partner. Also forms heterotrimers with PBX1 and HOX proteins

including HOXD9 and HOXD10 where PBX1 is the non-DNA-binding partner

Subcellular location: Nucleus (By similarity)

Secondary accessions: A8MV50

Alternative splicing: 2 isoforms: O00470-1 O00470-2

REFSEQ proteins: NP_002389.1

ENSEMBL proteins:

ENSP00000386708 ENSP00000386514 ENSP00000384127 ENSP00000381518 ENSP00000272369 ENSP00000384461

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MEIS1)
	Human Recombinant Proteins from Abnova (MEIS1)

OriGene Purified Recombinant Human Protein: MEIS1

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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Antibodies for MEIS1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for MEIS1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (MEIS1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MEIS1)
	Novus Biologicals Antibodies for MEIS1

Assays for MEIS1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O00470

ProtoNet protein and cluster: O00470

UniProtKB/Swiss-Prot: MEIS1_HUMAN, O00470

Similarity: Belongs to the TALE/MEIS homeobox family

Similarity: Contains 1 homeobox DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MEIS1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MEIS1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002398

Applied Biosystems Silencer® siRNAs for MEIS1

Sigma-Aldrich siRNA for MEIS1

Sigma-Aldrich shRNA for MEIS1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MEIS1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002398
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002398
untagged cDNA clone in CMV expression vector: NM_002398

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002398

UniProtKB/Swiss-Prot: MEIS1_HUMAN, O00470

Function: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4

in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and

vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid

leukemias

Genatlas biochemistry entry for MEIS1:

homeo domain protein,unusual,murine Meis1 (myeloid ecotropic viral integration site 1)

ortholog,expressed in fetal liver,normal immunohematopoietic tissues and cerebellum,binding DNA

cooperatively with the heterodimer E2A/myogenic transcription factors

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Meis1):

	hematopoietic system	lethality-prenatal/perinatal	liver/biliary system	skin/coat/nails
vision/eye

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IEA	--
GO:0003702	RNA polymerase II transcription factor activity	TAS	7565694
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for MEIS1

5/32 Interacting proteins for MEIS1 (ENSP00000272369³) via UniProtKB, MINT, and/or STRING (see all 32 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HOXA9	ENSP00000343619³	STRING (score=.999)
HOXB8	ENSP00000239144³	STRING (score=.969)
NUP98	ENSP00000316032³	STRING (score=.951)
FLT3	ENSP00000370369³	STRING (score=.95)
HOXA10	ENSP00000283921³	STRING (score=.939)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007275	multicellular organismal development	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MEIS1
1 Novoseek chemical compound relationship for MEIS1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	0.00	2	15755900 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MEIS1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MEIS1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002398

Sigma-Aldrich siRNA for MEIS1

Sigma-Aldrich shRNA for MEIS1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002398

REFSEQ mRNAs for MEIS1 gene:

NM_002398.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002398

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002398
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002398
                                 untagged cDNA clone in CMV expression vector: NM_002398

Additional cDNA sequence:

AF088018.1 AK098174.1 AK297109.1 AK297817.1 AK314949.1 BC043503.1 BX648626.1 CR612956.1

CR749827.1 U85707.1

16 DOTS entries:

DT.95147812 DT.100780375 DT.100647990 DT.452959 DT.208558 DT.99995176 DT.102832068 DT.91868493

DT.86853769 DT.120951306 DT.120951310 DT.120951322 DT.120951343 DT.40264477 DT.95263413 DT.99927451

24/149 AceView cDNA sequences (see all 149 ):

BG502562 AI968410 T16586 CB216927 BX119044 AW452245 CA943697 BM716621

AI648608 BM970182 NM_002398 N54742 CB854199 BU618932 CB215310 BG109428

AA035599 BP376045 AI669255 AA081754 AK098174 AI687866 AW243936 CB852923

highest scoring ESTs for MEIS1:

U85707 AA001443 AA017297 AA034934 AA035599 AA036998 AA228997 AA230050 AA230051 AA230104

Unigene Cluster for MEIS1:

Meis homeobox 1

Hs.526754 [show with all ESTs]

Unigene Representative Sequence: CR749827

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for MEIS1 (see all 10 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16a	·	16b	·	16c	^	17a	·	17b	^
SP1:					-				-				-		-				-						-						-																-
SP2:					-				-				-		-				-						-						-
SP3:																			-						-						-																-
SP4:									-				-		-				-						-						-
SP5:

ExUns:	18a	·	18b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for MEIS1

6 Ensembl transcripts including schematic representations:

ENST00000409517 ENST00000409622 ENST00000402908 ENST00000398506 ENST00000272369 ENST00000407092

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MEIS1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MEIS1

¹ / ² / ³

4 probe-sets matching MEIS1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40763_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U85707	1.00	1.00	1.00	1
204069_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002398	0.60	1.00	0.82	1
1559477_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204069_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks MEIS1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.526754
Expression variation in blood from EXPOLDB for MEIS1
UniProtKB/Swiss-Prot: MEIS1_HUMAN, O00470
Tissue specificity: Expressed at low level in normal immunohepatopoietic tissues, including the
fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression
seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the
cerebellum

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MEIS1 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	MEIS1¹	--	Meis homeobox 1	98.59(n) 98.68(a)	459288 XM_001166938.1 XP_001166938.1
cow (Bos taurus)	MEIS1¹	--	Meis homeobox 1	97.44(n) 100(a)	613877 XM_876237.2 XP_881330.1
rat (Rattus norvegicus)	Meis1¹	--	Meis homeobox 1	95.68(n) 98.41(a)	686117 XM_001070286.1 XP_001070286.1
mouse (Mus musculus)	Meis1^{1, 5}	11 (11.00 cM)⁵	Meis homeobox 1^{1, 5}	95.77(n)¹ 98.68(a)¹	17268¹ NM_010789.2¹ NP_034919.1¹ AB221660⁵ AK032947⁵ (see all 19)
zebrafish (Danio rerio)	meis1²	--	myeloid ecotropic viral integration 1	82.25(n)	170446 AF375871.1

About this table Species with no ortholog for MEIS1

ENSEMBL Gene Tree for MEIS1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MEIS1 gene

MEIS2² MEIS3P2² MEIS3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/646 NCBI SNPs in MEIS1 are shown (see all 646 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 259)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs11693221^1,2	C,F,H	66653490(+)	`TAAGCC/TATATA`	1	--	ng3¹		8	EU EA WA	840
	rs2901863^1,2	H	66649350(+)	`GAGGTT/GTCGTA`	1	V/F	mis¹ ese³		4	EU EA WA	420
	rs997153^1,2	A,C,F,H,O	66624551(-)	`CACTTC/TGGGAT`	1	--	int¹		13	NA EA EU WA	863
	rs1000756^1,2	A,C,F,H,O	66648338(-)	`TTCCAC/TCTTCT`	1	--	int¹		17	NA EA MN EU WA	1488
	rs2192954^1,2	A,C,F,H,O	66631025(+)	`TCTTTA/GGTTTG`	1	--	int¹		12	EU EA WA NA	1054
	rs2139246^1,2	A,C,F,H,O	66575364(+)	`ATCTCG/ACTTGT`	1	--	int¹		12	NS EU EA WA NA	666
	rs2216123^1,2	A,C,F,H,O	66646652(+)	`TTCCAA/GTTTTC`	1	--	int¹		7	EU EA WA NA	560
	rs1519103^1,2	A,C,F,H,O	66531385(+)	`TACCTT/GGCCAC`	1	--	int¹		22	EA NA EU WA	1800
	rs1519102^1,2	A,C,F,H,O	66531320(+)	`AATAAC/GATTTT`	1	--	int¹		11	NA EU EA WA	972
	rs2300486^1,2	A,C,F,H,O	66644908(+)	`TAGCTG/TACATC`	1	--	int¹		13	EA EU WA NA	2114

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HapMap Linkage Disequilibrium images for MEIS1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601739

9 Novoseek disease relationships for MEIS1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemogenesis	81.42	10	16648484 (3), 15755900 (3), 9226379 (1), 15681849 (1) (see all 6)
myeloid leukemia	71.92	8	9226379 (2), 17202314 (1), 10996203 (1), 14713950 (1) (see all 7)
leukemia	65.98	37	19109563 (7), 16469876 (3), 15755900 (3), 11161815 (2) (see all 14)
leukemia promyelocytic acute	40.86	1	11133770 (1)
acute leukemia	35.18	2	10996203 (1), 15160920 (1)
lymphoblastic leukemia acute	32.53	1	11314021 (1)
myeloid leukemia chronic	25.33	1	10602420 (1)
cancer	5.67	5	17949970 (2), 11704843 (1), 11161815 (1), 15755900 (1)
tumors	0.00	5	7565694 (2)

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1 PharmGKB disease relationship for MEIS1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872 12730115

About this table

Human Genome Epidemiology Navigator: MEIS1 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/102 PubMed articles for MEIS1 gene (see all 102 ):

Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. (PubMed id 7565694)^{1, 2, 3} Moskow J.J....Buchberg A.M. (1995)
Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene. (PubMed id 12609849)^{1, 3, 4} Okada Y....Doi T. (2003)
Cloning and mapping of the MEIS1 gene, the human homolog of a murine leukemogenic gene. (PubMed id 9226379)^{1, 3, 4} Smith J.E. Jr.... Takeshita K. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels. (PubMed id 19126776)^{1, 3} Xiong L....Rouleau G.A. (2009)
A role for MEIS1 in MLL-fusion gene leukemia. (PubMed id 19109563)^{1, 3} Kumar A.R....Kersey J.H. (2009)
Meis1-mediated apoptosis is caspase dependent and can be suppressed by coexpression of HoxA9 in murine and human cell lines. (PubMed id 15479723)^{1, 3} Wermuth P.J. and Buchberg A.M. (2005)
The MEIS1 oncogene is highly expressed in neuroblastoma and amplified in cell line IMR32. (PubMed id 11161815)^{1, 3} Spieker N....Versteeg R. (2001)
MEIS C termini harbor transcriptional activation domains that respond to cell signaling. (PubMed id 15654074)^{1, 3} Huang H....Featherstone M. (2005)
Expression of HOX genes in acute leukemia cell lines with and without MLL translocations. (PubMed id 15160920)^{1, 3} Quentmeier H....Drexler H.G. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4211	HGNC: 7000	AceView: MEIS1	Ensembl:ENSG00000143995	euGenes: HUgn4211
ECgene: MEIS1	H-InvDB: MEIS1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MEIS1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for MEIS1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for MEIS1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MEIS1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MEIS1		Antibodies for MEIS1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MEIS1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (MEIS1)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for MEIS1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for MEIS1

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MEIS1 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for MEIS1

Summaries
for MEIS1

Genomic Location
for MEIS1

Proteins
for MEIS1

Protein Domains/
Families
for MEIS1

Gene Function
for MEIS1

Pathways & Interactions
for MEIS1

Drugs & Compounds
for MEIS1

Transcripts
for MEIS1

Expression
for MEIS1

Orthologs
for MEIS1

Paralogs
for MEIS1

SNPs/Variants
for MEIS1

Disorders & Mutations
for MEIS1

Medical News
for MEIS1

Publications
for MEIS1

Search for MEIS1

Genome Databases showing MEIS1

Other Databases showing MEIS1

Specialized Databases showing MEIS1

Licensable Technologies
for MEIS1

Services
for MEIS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MEIS1 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor MEIS1

Summariesfor MEIS1

Genomic Locationfor MEIS1

Proteinsfor MEIS1

Protein Domains/Familiesfor MEIS1

Gene Functionfor MEIS1

Pathways & Interactionsfor MEIS1

Drugs & Compoundsfor MEIS1

Transcriptsfor MEIS1

Expression for MEIS1

Orthologsfor MEIS1

Paralogsfor MEIS1

SNPs/Variantsfor MEIS1

Disorders & Mutationsfor MEIS1

Medical Newsfor MEIS1

Publicationsfor MEIS1

Search for MEIS1

Genome Databases showing MEIS1

Other Databases showing MEIS1

Specialized Databases showing MEIS1

Licensable Technologiesfor MEIS1

Servicesfor MEIS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MEIS1

Summaries
for MEIS1

Genomic Location
for MEIS1

Proteins
for MEIS1

Protein Domains/
Families
for MEIS1

Gene Function
for MEIS1

Pathways & Interactions
for MEIS1

Drugs & Compounds
for MEIS1

Transcripts
for MEIS1

Expression
for MEIS1

Orthologs
for MEIS1

Paralogs
for MEIS1

SNPs/Variants
for MEIS1

Disorders & Mutations
for MEIS1

Medical News
for MEIS1

Publications
for MEIS1

Licensable Technologies
for MEIS1

Services
for MEIS1