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Aliases for MEIS1 Gene

Aliases for MEIS1 Gene

  • Meis Homeobox 1 2 3
  • Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog (Mouse) 2
  • Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 3
  • Leukemogenic Homolog Protein 3
  • Homeobox Protein Meis1 3
  • Meis1 (Mouse) Homolog 2
  • WUGSC:H_NH0444B04.1 3

External Ids for MEIS1 Gene

Previous GeneCards Identifiers for MEIS1 Gene

  • GC02P066796
  • GC02P066620
  • GC02P066637
  • GC02P066574
  • GC02P066516
  • GC02P066660

Summaries for MEIS1 Gene

Entrez Gene Summary for MEIS1 Gene

  • Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for MEIS1 Gene

MEIS1 (Meis Homeobox 1) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer and Transcriptional Regulatory Network in Embryonic Stem Cell. GO annotations related to this gene include sequence-specific DNA binding and chromatin binding. An important paralog of this gene is TGIF2LY.

UniProtKB/Swiss-Prot for MEIS1 Gene

  • Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.

Gene Wiki entry for MEIS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEIS1 Gene

Genomics for MEIS1 Gene

Regulatory Elements for MEIS1 Gene

Genomic Location for MEIS1 Gene

Start:
66,433,452 bp from pter
End:
66,573,869 bp from pter
Size:
140,418 bases
Orientation:
Plus strand

Genomic View for MEIS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEIS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEIS1 Gene

Proteins for MEIS1 Gene

  • Protein details for MEIS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00470-MEIS1_HUMAN
    Recommended name:
    Homeobox protein Meis1
    Protein Accession:
    O00470
    Secondary Accessions:
    • A8MV50

    Protein attributes for MEIS1 Gene

    Size:
    390 amino acids
    Molecular mass:
    43016 Da
    Quaternary structure:
    • Interacts with the N-terminal region of PBX1 to form a heterodimer which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterodimers with PBX2. Forms heterotrimers with PBX1 or PBX2 and a number of HOX proteins including HOXA9, HOXD4 and HOXD9 where it acts as a non-DNA-binding partner. Also forms heterotrimers with PBX1 and HOX proteins including HOXD9 and HOXD10 where PBX1 is the non-DNA-binding partner.

    Alternative splice isoforms for MEIS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEIS1 Gene

Proteomics data for MEIS1 Gene at MOPED

Post-translational modifications for MEIS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MEIS1 Gene

No data available for DME Specific Peptides for MEIS1 Gene

Domains for MEIS1 Gene

Gene Families for MEIS1 Gene

HGNC:
  • TALE :Homeoboxes / TALE class

Protein Domains for MEIS1 Gene

Graphical View of Domain Structure for InterPro Entry

O00470

UniProtKB/Swiss-Prot:

MEIS1_HUMAN :
  • O00470
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the TALE/MEIS homeobox family.
genes like me logo Genes that share domains with MEIS1: view

Function for MEIS1 Gene

Molecular function for MEIS1 Gene

GENATLAS Biochemistry: homeo domain protein,unusual,murine Meis1 (myeloid ecotropic viral integration site 1) ortholog,expressed in fetal liver,normal immunohematopoietic tissues and cerebellum,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors
UniProtKB/Swiss-Prot Function: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.

Gene Ontology (GO) - Molecular Function for MEIS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with MEIS1: view
genes like me logo Genes that share phenotypes with MEIS1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MEIS1 Gene

Localization for MEIS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEIS1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEIS1 Gene COMPARTMENTS Subcellular localization image for MEIS1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for MEIS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with MEIS1: view

Pathways for MEIS1 Gene

genes like me logo Genes that share pathways with MEIS1: view

Pathways by source for MEIS1 Gene

1 KEGG pathway for MEIS1 Gene

Gene Ontology (GO) - Biological Process for MEIS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0002089 lens morphogenesis in camera-type eye IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0030097 hemopoiesis --
genes like me logo Genes that share ontologies with MEIS1: view

Compounds for MEIS1 Gene

(1) HMDB Compounds for MEIS1 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4

(3) Novoseek inferred chemical compound relationships for MEIS1 Gene

Compound -log(P) Hits PubMed IDs
arsenite 27 1
retinoic acid 22.5 1
tyrosine 0 3
genes like me logo Genes that share compounds with MEIS1: view

Transcripts for MEIS1 Gene

Unigene Clusters for MEIS1 Gene

Meis homeobox 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEIS1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - - -
SP5:
SP6: - - -
SP7: -
SP8: - - -
SP9: - - - - - -
SP10: -

ExUns: 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for MEIS1 Gene

GeneLoc Exon Structure for
MEIS1
ECgene alternative splicing isoforms for
MEIS1

Expression for MEIS1 Gene

mRNA expression in normal human tissues for MEIS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MEIS1 Gene

SOURCE GeneReport for Unigene cluster for MEIS1 Gene Hs.526754

mRNA Expression by UniProt/SwissProt for MEIS1 Gene

O00470-MEIS1_HUMAN
Tissue specificity: Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum
genes like me logo Genes that share expressions with MEIS1: view

No data available for mRNA differential expression in normal tissues for MEIS1 Gene

Orthologs for MEIS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MEIS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEIS1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MEIS1 35
  • 97.44 (n)
  • 100 (a)
MEIS1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEIS1 35
  • 97.18 (n)
  • 100 (a)
MEIS1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Meis1 16
Meis1 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MEIS1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEIS1 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves MEIS1 35
  • 88.21 (n)
  • 96.92 (a)
MEIS1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEIS1 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.607 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12496 35
zebrafish
(Danio rerio)
Actinopterygii meis1 35
meis1 36
  • 95 (a)
OneToMany
meis4.1a 36
  • 77 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta hth 36
  • 48 (a)
OneToMany
hth 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-62 37
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for MEIS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MEIS1 Gene

ENSEMBL:
Gene Tree for MEIS1 (if available)
TreeFam:
Gene Tree for MEIS1 (if available)

Paralogs for MEIS1 Gene

Paralogs for MEIS1 Gene

genes like me logo Genes that share paralogs with MEIS1: view

Variants for MEIS1 Gene

Sequence variations from dbSNP and Humsavar for MEIS1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs764342 -- 66,570,319(-) ATAAA(A/C)TACAT intron-variant
rs876526 -- 66,436,541(+) ACTGA(G/T)GTAGT intron-variant
rs939136 -- 66,450,399(+) GCTGA(C/G)GAGCT intron-variant
rs997152 -- 66,543,957(-) GCAAG(A/T)TGGAT intron-variant
rs997153 -- 66,543,915(-) CACTT(C/T)GGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEIS1 Gene

Variant ID Type Subtype PubMed ID
nsv834248 CNV Gain 17160897

Relevant External Links for MEIS1 Gene

HapMap Linkage Disequilibrium report
MEIS1
Human Gene Mutation Database (HGMD)
MEIS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEIS1 Gene

Disorders for MEIS1 Gene

UniProtKB/Swiss-Prot

MEIS1_HUMAN
  • Restless legs syndrome 7 (RLS7) [MIM:612853]: A neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. The majority of patients also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for MEIS1 Gene

(9) Novoseek inferred disease relationships for MEIS1 Gene

Disease -log(P) Hits PubMed IDs
leukemogenesis 82.3 11
myeloid leukemia 71 8
leukemia 67.3 29
acute leukemia 40 2
leukemia promyelocytic acute 39.3 1

Relevant External Links for MEIS1

Genetic Association Database (GAD)
MEIS1
Human Genome Epidemiology (HuGE) Navigator
MEIS1
genes like me logo Genes that share disorders with MEIS1: view

Publications for MEIS1 Gene

  1. Cloning and mapping of the MEIS1 gene, the human homolog of a murine leukemogenic gene. (PMID: 9226379) Smith J.E. Jr. … Takeshita K. (Genomics 1997) 3 4 23
  2. Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. (PMID: 7565694) Moskow J.J. … Buchberg A.M. (Mol. Cell. Biol. 1995) 2 3 23
  3. Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene. (PMID: 12609849) Okada Y. … Doi T. (Blood 2003) 3 4 23
  4. MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels. (PMID: 19126776) Xiong L. … Rouleau G.A. (Hum. Mol. Genet. 2009) 3 23 48
  5. The combined expression of HOXA4 and MEIS1 is an independent prognostic factor in patients with AML. (PMID: 19563517) Zangenberg M. … Hokland P. (Eur. J. Haematol. 2009) 3 23

Products for MEIS1 Gene

Sources for MEIS1 Gene

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