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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MEIS1 Gene

protein-coding GIFtS: 61
GCID: GC02P066660

Meis homeobox 1

(Previous names: Meis1 (mouse) homolog, Meis1, myeloid ecotropic viral integration...)

Explore 27 diseases affiliated with
MEIS1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Meis Homeobox 1¹ ²		Homeobox Protein Meis1²
Meis1 (Mouse) Homolog¹		Leukemogenic Homolog Protein²
Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog (Mouse)¹		Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog²
WUGSC:H_NH0444B04.1²

External Ids:	HGNC: 7000¹	Entrez Gene: 4211²	Ensembl: ENSG00000143995⁷	OMIM: 601739⁵	UniProtKB: O00470³

Export aliases for MEIS1 gene to outside databases

Previous GC identifers: GC02P066796 GC02P066620 GC02P066637 GC02P066574 GC02P066516 GC02P066397

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MEIS1:

Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in

normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein

belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MEIS1_HUMAN, O00470

Function: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1

or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a

cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias

Gene Wiki entry for MEIS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MEIS1 gene promoter:
STAT5B CUTL1 Gfi-1 c-Ets-1 CREB AREB6 S8 SRY E2F deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MEIS1 promoter sequence

Search SABiosciences Chromatin IP Primers for MEIS1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEIS1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p14 Ensembl cytogenetic band: 2p14 HGNC cytogenetic band: 2p14

MEIS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEIS1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P066660: view genomic region (about GC identifiers)

Start:	66,660,584 bp from pter	End:	66,799,891 bp from pter
Size:	139,308 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MEIS1_HUMAN, O00470 (See protein sequence)

Recommended Name: Homeobox protein Meis1

Size: 390 amino acids; 43016 Da

Subunit: Interacts with the N-terminal region of PBX1 to form a heterodimer which binds DNA including a cAMP-responsive

sequence in CYP17. Also forms heterodimers with PBX2. Forms heterotrimers with PBX1 or PBX2 and a number of HOX

proteins including HOXA9, HOXD4 and HOXD9 where it acts as a non-DNA-binding partner. Also forms heterotrimers with

PBX1 and HOX proteins including HOXD9 and HOXD10 where PBX1 is the non-DNA-binding partner

Subcellular location: Nucleus (By similarity)

Secondary accessions: A8MV50

Alternative splicing: 2 isoforms: O00470-1 O00470-2

Explore the universe of human proteins at neXtProt for MEIS1: NX_O00470

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O00470

MEIS1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002389.1

ENSEMBL proteins:

ENSP00000454209 ENSP00000272369 ENSP00000381518 ENSP00000440571 ENSP00000386514

ENSP00000397418 ENSP00000386708 ENSP00000395827 ENSP00000384461 ENSP00000403206

Human Recombinant Protein Products for MEIS1:

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	Novus Biologicals MEIS1 Proteins Novus Biologicals MEIS1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MEIS1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005667	transcription factor complex	IEA	--

MEIS1 for ontologies About GeneDecksing

MEIS1 Antibody Products:

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Assay Products for MEIS1:

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	Uscn ELISAs and CLIAs for MEIS1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MEIS1 for domains About GeneDecksing

3 InterPro domains/families:

IPR008422 Homeobox_KN_domain

IPR001356 Homeodomain

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry O00470

ProtoNet protein and cluster: O00470

UniProtKB/Swiss-Prot: MEIS1_HUMAN, O00470

Similarity: Belongs to the TALE/MEIS homeobox family

Similarity: Contains 1 homeobox DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MEIS1_HUMAN, O00470

Function: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1

or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a

cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias

Genatlas biochemistry entry for MEIS1:

homeo domain protein,unusual,murine Meis1 (myeloid ecotropic viral integration site 1) ortholog,expressed in fetal

liver,normal immunohematopoietic tissues and cerebellum,binding DNA cooperatively with the heterodimer E2A/myogenic

transcription factors

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003682	chromatin binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	--	--
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	IEA	--
GO:0005515	protein binding	IPI	--

MEIS1 for ontologies About GeneDecksing

Phenotypes:
11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Meis1):

cardiovascular system	cellular	hematopoietic system	integument	limbs/digits/tail
liver/biliary system	mortality/aging	nervous system	renal/urinary system	respiratory system
vision/eye

MEIS1 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MEIS1

miRNA Products:		miRTarBase miRNAs that target MEIS1: hsa-mir-98 (MIRT004946), hsa-let-7a (MIRT004962), hsa-mir-155 (MIRT000287), hsa-mir-204 (MIRT000189)

		OriGene 3'-UTR Clone: MEIS1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEIS1
		8/112 QIAGEN miScript miRNA Assays for microRNAs that regulate MEIS1 (see all 112):
		hsa-miR-607 hsa-miR-3938 hsa-miR-300 hsa-miR-374a hsa-miR-371-5p hsa-miR-10b* hsa-miR-208b hsa-miR-376a*

		SwitchGear 3'UTR luciferase reporter plasmid: MEIS1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEIS1 (see all 7) OriGene shRNA RFP: MEIS1 OriGene siRNA: MEIS1
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		Sirion Biotech Custom design and validation of potent shRNA sequences against MEIS1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for MEIS1
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEIS1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEIS1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MEIS1 (NM_002398)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MEIS1
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEIS1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Transcriptional Regulatory Network in Embryonic Stem Cell

Transcriptional Regulatory Network in Embryonic Stem Cell

1.00

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MEIS1

Transcriptional Regulatory Network in Embryonic Stem Cell

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MEIS1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/45 Interacting proteins for MEIS1 (O00470^{1, 3} ENSP00000272369⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 45)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CREB1	P16220¹^,³, ENSP00000387699⁴	EBI-1210694,EBI-711855 I2D: score=1 STRING: ENSP00000387699
ETS1	P14921¹^,³, ENSP00000376436⁴	EBI-1210694,EBI-913209 I2D: score=1 STRING: ENSP00000376436
TLX1	P31314¹^,³, ENSP00000359215⁴	EBI-1210694,EBI-2820655 I2D: score=1 STRING: ENSP00000359215
HOXA5	P20719³, ENSP00000222726⁴	I2D: score=2 STRING: ENSP00000222726
HOXB13	Q92826³, ENSP00000290295⁴	I2D: score=2 STRING: ENSP00000290295

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0002089	lens morphogenesis in camera-type eye	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0030097	hemopoiesis	--	--
GO:0045638	negative regulation of myeloid cell differentiation	ISS	--

MEIS1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MEIS1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MEIS1

1 HMDB Compound for MEIS1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--

3 Novoseek chemical compound relationships for MEIS1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
arsenite	27	1	11133770 (1)
retinoic acid	22.5	1	11133770 (1)
tyrosine	0	3	15755900 (2), 19514512 (1)

Search CenterWatch for drugs/clinical trials and news about MEIS1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MEIS1 gene:

NM_002398.2

Unigene Cluster for MEIS1:

Meis homeobox 1

Hs.526754 [show with all ESTs]

Unigene Representative Sequence: CR749827

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000496248 ENST00000560281 ENST00000491706 ENST00000272369(uc002sdu.3 uc010yqi.2)

ENST00000488550(uc002sdt.3) ENST00000490726 ENST00000398506 ENST00000495021(uc002sdw.1)

ENST00000409622 ENST00000437869 ENST00000466811 ENST00000498705 ENST00000475239

ENST00000409517 ENST00000542964 ENST00000450027 ENST00000407092(uc010yqh.2)

ENST00000444274

miRNA Products:		OriGene 3'-UTR Clone: MEIS1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEIS1
		8/112 QIAGEN miScript miRNA Assays for microRNAs that regulate MEIS1 (see all 112):
		hsa-miR-607 hsa-miR-3938 hsa-miR-300 hsa-miR-374a hsa-miR-371-5p hsa-miR-10b* hsa-miR-208b hsa-miR-376a*

		SwitchGear 3'UTR luciferase reporter plasmid: MEIS1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEIS1 (see all 7) OriGene shRNA RFP: MEIS1 OriGene siRNA: MEIS1
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		Sirion Biotech Custom design and validation of potent shRNA sequences against MEIS1

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		GenScript: all cDNA clones in your preferred vector: MEIS1 (NM_002398)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEIS1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEIS1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEIS1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEIS1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEIS1

Additional cDNA sequence:

AK098174.1 AK297109.1 AK297817.1 AK314949.1 BC043503.1 BX648626.1 CR749827.1 U85707.1

16 DOTS entries:

DT.95147812 DT.100780375 DT.100647990 DT.452959 DT.99995176 DT.208558 DT.102832068 DT.91868493

DT.86853769 DT.120951306 DT.120951310 DT.120951322 DT.120951343 DT.40264477 DT.95263413 DT.99927451

24/149 AceView cDNA sequences (see all 149):

AI648608 AA081754 BU618932 CB216927 CA943697 CB852923 U85707 BM716621

AI669255 BG109428 CR612956 BP376045 BX119044 CA867974 AW452245 AI653624

N54742 BM663955 BM014915 T16586 AI978827 CB854199 AA976262 AA035599

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for MEIS1 (see all 10) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16a	·	16b	·	16c	^	17a	·	17b	^
SP1:					-				-				-		-				-						-						-																-
SP2:					-				-				-		-				-						-						-
SP3:																			-						-						-																-
SP4:									-				-		-				-						-						-
SP5:

ExUns:	18a	·	18b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for MEIS1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MEIS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGTATTTT

About this image

MEIS1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/14 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 14)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Limb Bud

Limb Bud Mesenchyme Cells

Selective marker (cell-identifying gene)

Mesoderm

Bone, Cartilage

Prechondrocytic Mesenchymal Cells

Bone, Cartilage

Limb

Zeugopod

Prechondrocytic Mesenchymal Cells

Bone, Cartilage

Kidney

Metanephric Mesenchyme

Metanephric Mesenchyme Cells

Kidney

Spinal Cord

Spinal Dorsal Columns

Dorsal Spinal Cord Progenitor Cells

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Bone

Zeugopod Epiphyseal End

Bone

Zeugopod Periosteum

Bone

Brain

Medulla Oblongata

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/13 LifeMap Cells (see all 13)

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

Dorsal forebrain-like neurons (Generation of midbra...)

Brain

Trophoblast-like cells (Generation of tropho...)

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Extraembryonic endoderm-like cells (Generation of extrae...)

See MEIS1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MEIS1

SOURCE GeneReport for Unigene cluster: Hs.526754

UniProtKB/Swiss-Prot: MEIS1_HUMAN, O00470

Tissue specificity: Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed

in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid

phenotype. Also expressed at high levels in the cerebellum

SABiosciences Expression via Pathway-Focused PCR Arrays including MEIS1:

Leukemia in human mouse rat

Homeobox (HOX) Genes in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEIS1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEIS1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEIS1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MEIS1 gene from 8/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MEIS1¹	Meis homeobox 1	88.21(n) 96.92(a)		395589 NM_001139477.1 NP_001132949.1
lizard (Anolis carolinensis)	Reptilia	MEIS3⁶ MEIS1⁶	--	75(a) 75(a)	possible ortholog 1 ↔ 1	GL344351.1(8818-12530) 1(125268756-125435774)
African clawed frog (Xenopus laevis)	Amphibia	Xl.607²	Xenopus laevis XMeis1-4 protein mRNA, partial cds	83.58(n)		U68387.1
zebrafish (Danio rerio)	Actinopterygii	meis1²	myeloid ecotropic viral integration 1	82.25(n)		170446 AF375871.1
fruit fly (Drosophila melanogaster)	Insecta	hth^{1 , 3}	brain development transcription factor³ homothorax¹	51(a)³ 62.36(n)¹ 68.26(a)¹		41273¹ NM_057228.4¹ NP_476576.1¹
worm (Caenorhabditis elegans)	Secernentea	unc-62^{1 , 3}	Expression: germ-line cells, blastula embryo, more³ Protein UNC-62¹	52(a)³ 54.31(n)¹ 53.35(a)¹		V(4497281-4510705)³ 178845¹ NM_001029002.1¹ NP_001024173.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	BLH10⁶ ATH1⁶ (see all 13)	homeobox protein ATH1 (see all 13)	9(a) 9(a) (see all 13)	many ↔ many many ↔ many (see all 13)	1(6809724-6812663) 4(15914722-15918044)
rice (Oryza sativa)	Liliopsida	-- -- (see all 14)	homeobox domain containing protein, expressed (see all 14)	9(a) 9(a) (see all 14)	many ↔ many many ↔ many (see all 14)	5(22291438-22296009) 3(1393427-1399137)

ENSEMBL Gene Tree for MEIS1 (if available)
TreeFam Gene Tree for MEIS1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for MEIS1 gene

TGIF2LY² MEIS2² TGIF2² PKNOX1² PKNOX2² TGIF2LX² TGIF1² MEIS3²

12 SIMAP similar genes for MEIS1 using alignment to 11 protein entries: MEIS1_HUMAN (see all proteins):

meis1 HB103 MEIS2 MEIS3 MEIS3P1 MEIS3P2

TGIF1 PKNOX1 TGIF2 PKNOX2 TGIF2LY WUGSC

MEIS1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112618701^1,2	C	--	66396665(+)	`ACTCCG/CGCAGC`	1	--	us2k¹		1		NA	2
rs74945924^1,2	F	--	66397667(+)	`CGCACG/AGGGAC`	1	--	us2k¹		1		EA	120
rs1568319^1,2	C,F,H	--	66398030(-)	`agaaaA/Gggaaa`	1	--	ut5¹ trp³		2		NS NA	288
rs73937909^1,2	C	--	66398495(+)	`AGAGGA/TTTTAT`	1	--	int¹		2		WA	120
rs72819298^1,2	C	--	66398630(+)	`TTTTTT/AAAAAA`	1	--	int¹		3		WA NA	240
rs10173713^1,2	C	--	66399251(+)	`ACTCTC/TAGCGC`	1	--	int¹		0	--	--	--	--
rs59655759^1,2	C,F	--	66400106(+)	`GGCCAC/TCGAAT`	1	--	int¹		3		WA CSA	122
rs35067867^1,2	C	--	66400438(-)	`TGGCAT/CCTTTA`	2	/D /G	mis¹		1		NA	74
rs7557522^1,2	C,F,A	--	66401129(+)	`GGTTGT/CTTTCT`	1	--	int¹		4		WA NA	242
rs75808936^1,2	C	--	66401285(+)	`ATTTTT/AAAAAA`	1	--	int¹		1		NA	2

HapMap Linkage Disequilibrium report for MEIS1 (66660584 - 66799891 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MEIS1: --
Human Gene Mutation Database (HGMD): MEIS1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEIS1

DNA2.0 Custom Variant and Variant Library Synthesis for MEIS1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MEIS1 for disorders About GeneDecksing

OMIM gene information: 601739 OMIM disorders: --

UniProtKB/Swiss-Prot: MEIS1_HUMAN, O00470

Defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7 (RLS7) [MIM:612853].

Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant

sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The

disorder results in nocturnal insomnia and chronic sleep deprivation

20/27 diseases for MEIS1 (see all 27): About MalaCards

restless legs syndrome myeloid leukemia lymphoblastic leukemia acute promyelocytic leukemia

leukemia insomnia acute lymphoblastic leukemia acute lymphocytic leukemia

acute myeloid leukemia tourette syndrome lymphocytic leukemia sleep disorder

acute leukemia embryonal carcinoma myelodysplastic syndrome adhd

hematopoiesis t-cell leukemia ovarian cancer pancreatic cancer

1 disease from the University of Copenhagen DISEASES database for MEIS1:

Leukemia

9 Novoseek disease relationships for MEIS1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemogenesis	82.3	11	16648484 (3), 15755900 (3), 9226379 (1), 15681849 (1) (see all 7)
myeloid leukemia	71	8	9226379 (2), 17202314 (1), 10996203 (1), 14713950 (1) (see all 7)
leukemia	67.3	39	19109563 (7), 16469876 (3), 15755900 (3), 11161815 (2) (see all 16)
acute leukemia	40	2	10996203 (1), 15160920 (1)
leukemia promyelocytic acute	39.3	1	11133770 (1)
lymphoblastic leukemia acute	30.8	1	11314021 (1)
myeloid leukemia chronic	23.5	1	10602420 (1)
cancer	6.25	5	17949970 (2), 11704843 (1), 11161815 (1), 15755900 (1)
tumors	0	7	7565694 (2), 19825192 (2)

Human Genome Epidemiology (HuGE) Navigator: MEIS1 (13 documents)

Export disorders for MEIS1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MEIS1 gene, integrated from 9 sources (see all 136):
(articles sorted by number of sources associating them with MEIS1)

Utopia: connect your pdf to the dynamic
world of online information

Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. (PubMed id 7565694)^{1, 3, 9} Moskow J.J....Buchberg A.M. (1995)
Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene. (PubMed id 12609849)^{1, 2, 9} Okada Y....Doi T. (2003)
Cloning and mapping of the MEIS1 gene, the human homolog of a murine leukemogenic gene. (PubMed id 9226379)^{1, 2, 9} Smith J.E. Jr.... Takeshita K. (1997)
MEIS1 p.R272H in familial restless legs syndrome. (PubMed id 19620614)^{1, 2} VilariA+o-GA1ell C....Lin S.C. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3. (PubMed id 20237320)^{1, 9} Argiropoulos B....Humphries R.K. (2010)
A role for MEIS1 in MLL-fusion gene leukemia. (PubMed id 19109563)^{1, 9} Kumar A.R....Kersey J.H. (2009)
MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels. (PubMed id 19126776)^{1, 9} Xiong L....Rouleau G.A. (2009)
The combined expression of HOXA4 and MEIS1 is an inde pendent prognostic factor in patients with AML. (PubMed id 19563517)^{1, 9} Zangenberg M....Hokland P. (2009)
PBX1 and MEIS1 up-regulate SOX3 gene expression by di rect interaction with a consensus binding site within the basal promoter region . (PubMed id 19799567)^{1, 9} Mojsin M. and Stevanovic M. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4211	HGNC: 7000	AceView: MEIS1	Ensembl:ENSG00000143995	euGenes: HUgn4211
ECgene: MEIS1	H-InvDB: MEIS1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MEIS1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MEIS1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MEIS1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MEIS1 gene:
Search GeneIP for patents involving MEIS1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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