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Aliases for MEIS1 Gene

Aliases for MEIS1 Gene

  • Meis Homeobox 1 2 3
  • Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog (Mouse) 2
  • Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 3
  • Leukemogenic Homolog Protein 3
  • Meis1 (Mouse) Homolog 2
  • WUGSC:H_NH0444B04.1 3

External Ids for MEIS1 Gene

Previous GeneCards Identifiers for MEIS1 Gene

  • GC02P066796
  • GC02P066620
  • GC02P066637
  • GC02P066574
  • GC02P066516
  • GC02P066660
  • GC02P066397

Summaries for MEIS1 Gene

Entrez Gene Summary for MEIS1 Gene

  • Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for MEIS1 Gene

MEIS1 (Meis Homeobox 1) is a Protein Coding gene. Diseases associated with MEIS1 include restless legs syndrome and restless legs syndrome 7. Among its related pathways are Signaling pathways regulating pluripotency of stem cells and Transcriptional misregulation in cancer. GO annotations related to this gene include sequence-specific DNA binding and chromatin binding. An important paralog of this gene is TGIF2LY.

UniProtKB/Swiss-Prot for MEIS1 Gene

  • Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.

Gene Wiki entry for MEIS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEIS1 Gene

Genomics for MEIS1 Gene

Regulatory Elements for MEIS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MEIS1 Gene

Chromosome:
2
Start:
66,433,452 bp from pter
End:
66,573,869 bp from pter
Size:
140,418 bases
Orientation:
Plus strand

Genomic View for MEIS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEIS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEIS1 Gene

Proteins for MEIS1 Gene

  • Protein details for MEIS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00470-MEIS1_HUMAN
    Recommended name:
    Homeobox protein Meis1
    Protein Accession:
    O00470
    Secondary Accessions:
    • A8MV50

    Protein attributes for MEIS1 Gene

    Size:
    390 amino acids
    Molecular mass:
    43016 Da
    Quaternary structure:
    • Interacts with the N-terminal region of PBX1 to form a heterodimer which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterodimers with PBX2. Forms heterotrimers with PBX1 or PBX2 and a number of HOX proteins including HOXA9, HOXD4 and HOXD9 where it acts as a non-DNA-binding partner. Also forms heterotrimers with PBX1 and HOX proteins including HOXD9 and HOXD10 where PBX1 is the non-DNA-binding partner.

    Alternative splice isoforms for MEIS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEIS1 Gene

Proteomics data for MEIS1 Gene at MOPED

Post-translational modifications for MEIS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MEIS1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MEIS1 (MEIS1)

No data available for DME Specific Peptides for MEIS1 Gene

Domains & Families for MEIS1 Gene

Gene Families for MEIS1 Gene

Protein Domains for MEIS1 Gene

Graphical View of Domain Structure for InterPro Entry

O00470

UniProtKB/Swiss-Prot:

MEIS1_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/MEIS homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the TALE/MEIS homeobox family.
genes like me logo Genes that share domains with MEIS1: view

Function for MEIS1 Gene

Molecular function for MEIS1 Gene

GENATLAS Biochemistry:
homeo domain protein,unusual,murine Meis1 (myeloid ecotropic viral integration site 1) ortholog,expressed in fetal liver,normal immunohematopoietic tissues and cerebellum,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors
UniProtKB/Swiss-Prot Function:
Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.

Gene Ontology (GO) - Molecular Function for MEIS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA --
genes like me logo Genes that share ontologies with MEIS1: view
genes like me logo Genes that share phenotypes with MEIS1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEIS1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MEIS1 Gene

Localization for MEIS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEIS1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEIS1 Gene COMPARTMENTS Subcellular localization image for MEIS1 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for MEIS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with MEIS1: view

Pathways & Interactions for MEIS1 Gene

genes like me logo Genes that share pathways with MEIS1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for MEIS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0002089 lens morphogenesis in camera-type eye IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007626 locomotory behavior IEA --
genes like me logo Genes that share ontologies with MEIS1: view

No data available for SIGNOR curated interactions for MEIS1 Gene

Drugs & Compounds for MEIS1 Gene

(2) Drugs for MEIS1 Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
tyrosine Nutra 547

(2) Additional Compounds for MEIS1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
arsenite
  • AArsenite (AsO33-)
  • Arsenic (III) oxide
  • Arsenic (III) trioxide
  • Arsenic sesquioxide
  • Arsenic trioxide
15502-74-6
retinoic acid
302-79-4
genes like me logo Genes that share compounds with MEIS1: view

Transcripts for MEIS1 Gene

Unigene Clusters for MEIS1 Gene

Meis homeobox 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEIS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEIS1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - - -
SP5:
SP6: - - -
SP7: -
SP8: - - -
SP9: - - - - - -
SP10: -

ExUns: 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for MEIS1 Gene

GeneLoc Exon Structure for
MEIS1
ECgene alternative splicing isoforms for
MEIS1

Expression for MEIS1 Gene

mRNA expression in normal human tissues for MEIS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MEIS1 Gene

This gene is overexpressed in Fetal ovary (27.4) and Ovary (22.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MEIS1 Gene



SOURCE GeneReport for Unigene cluster for MEIS1 Gene Hs.526754

mRNA Expression by UniProt/SwissProt for MEIS1 Gene

O00470-MEIS1_HUMAN
Tissue specificity: Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum
genes like me logo Genes that share expression patterns with MEIS1: view

Protein tissue co-expression partners for MEIS1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MEIS1 Gene

Orthologs for MEIS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MEIS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MEIS1 35
  • 97.44 (n)
  • 100 (a)
MEIS1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEIS1 35
  • 97.18 (n)
  • 100 (a)
MEIS1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Meis1 16
Meis1 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MEIS1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEIS1 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MEIS1 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves MEIS1 35
  • 88.21 (n)
  • 96.92 (a)
MEIS1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEIS1 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.607 35
zebrafish
(Danio rerio)
Actinopterygii meis1 35
meis1 36
  • 95 (a)
OneToMany
meis4.1a 36
  • 77 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12496 35
fruit fly
(Drosophila melanogaster)
Insecta hth 37
  • 51 (a)
hth 36
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-62 37
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for MEIS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MEIS1 Gene

ENSEMBL:
Gene Tree for MEIS1 (if available)
TreeFam:
Gene Tree for MEIS1 (if available)

Paralogs for MEIS1 Gene

Paralogs for MEIS1 Gene

genes like me logo Genes that share paralogs with MEIS1: view

Variants for MEIS1 Gene

Sequence variations from dbSNP and Humsavar for MEIS1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs764342 -- 66,570,319(-) ATAAA(A/C)TACAT intron-variant
rs876526 -- 66,436,541(+) ACTGA(G/T)GTAGT intron-variant
rs997152 -- 66,543,957(-) GCAAG(A/T)TGGAT intron-variant
rs997153 -- 66,543,915(-) CACTT(C/T)GGGAT intron-variant
rs1000756 -- 66,567,702(-) TTCCA(C/T)CTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEIS1 Gene

Variant ID Type Subtype PubMed ID
nsv834248 CNV Gain 17160897

Variation tolerance for MEIS1 Gene

Residual Variation Intolerance Score: 32.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEIS1 Gene

HapMap Linkage Disequilibrium report
MEIS1
Human Gene Mutation Database (HGMD)
MEIS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEIS1 Gene

Disorders for MEIS1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MEIS1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
restless legs syndrome
  • wittmaack-ekbom syndrome
restless legs syndrome 7
  • restless legs syndrome, susceptibility to, 7
myeloid leukemia
  • myeloid leukemia, nos, without mention of remission
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association
Search MEIS1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MEIS1_HUMAN
  • Restless legs syndrome 7 (RLS7) [MIM:612853]: A neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. The majority of patients also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Relevant External Links for MEIS1

Genetic Association Database (GAD)
MEIS1
Human Genome Epidemiology (HuGE) Navigator
MEIS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEIS1
genes like me logo Genes that share disorders with MEIS1: view

No data available for Genatlas for MEIS1 Gene

Publications for MEIS1 Gene

  1. Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. (PMID: 7565694) Moskow J.J. … Buchberg A.M. (Mol. Cell. Biol. 1995) 2 23 67
  2. c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. (PMID: 20093773) Jin S. … Gewirtz A.M. (J. Clin. Invest. 2010) 23 67
  3. PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region. (PMID: 19799567) Mojsin M. … Stevanovic M. (Biochem. J. 2010) 23 67
  4. Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3. (PMID: 20237320) Argiropoulos B. … Humphries R.K. (Blood 2010) 23 67
  5. A role for MEIS1 in MLL-fusion gene leukemia. (PMID: 19109563) Kumar A.R. … Kersey J.H. (Blood 2009) 23 67

Products for MEIS1 Gene

Sources for MEIS1 Gene

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