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MEIS1 Gene

protein-coding   GIFtS: 63
GCID: GC02P066660

Meis Homeobox 1

(Previous names: Meis1 (mouse) homolog, Meis1, myeloid ecotropic viral integration...)
  See MEIS1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Meis Homeobox 11 2     Homeobox Protein Meis12
Meis1 (Mouse) Homolog1     Leukemogenic Homolog Protein2
Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog (Mouse)1     Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog2
WUGSC:H_NH0444B04.12     

External Ids:    HGNC: 70001   Entrez Gene: 42112   Ensembl: ENSG000001439957   OMIM: 6017395   UniProtKB: O004703   

Export aliases for MEIS1 gene to outside databases

Previous GC identifers: GC02P066796 GC02P066620 GC02P066637 GC02P066574 GC02P066516 GC02P066397


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MEIS1 Gene:
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role
in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox
protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.
(provided by RefSeq, Jul 2008)

GeneCards Summary for MEIS1 Gene:
MEIS1 (Meis homeobox 1) is a protein-coding gene. Diseases associated with MEIS1 include collagen type vi-related disorders, and acute myeloid leukemia. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding. An important paralog of this gene is MEIS2.

UniProtKB/Swiss-Prot: MEIS1_HUMAN, O00470
Function: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with
PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function
as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias

Gene Wiki entry for MEIS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MEIS1 gene promoter:
         STAT5B   CUTL1   Gfi-1   c-Ets-1   CREB   AREB6   S8   SRY   E2F   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMEIS1 promoter sequence
   Search Chromatin IP Primers for MEIS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEIS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p14   Ensembl cytogenetic band:  2p14   HGNC cytogenetic band: 2p14

MEIS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEIS1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P066660:  view genomic region     (about GC identifiers)

Start:
66,660,584 bp from pter      End:
66,801,001 bp from pter
Size:
140,418 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MEIS1_HUMAN, O00470 (See protein sequence)
Recommended Name: Homeobox protein Meis1  
Size: 390 amino acids; 43016 Da
Subunit: Interacts with the N-terminal region of PBX1 to form a heterodimer which binds DNA including a
cAMP-responsive sequence in CYP17. Also forms heterodimers with PBX2. Forms heterotrimers with PBX1 or PBX2 and a
number of HOX proteins including HOXA9, HOXD4 and HOXD9 where it acts as a non-DNA-binding partner. Also forms
heterotrimers with PBX1 and HOX proteins including HOXD9 and HOXD10 where PBX1 is the non-DNA-binding partner
Secondary accessions: A8MV50
Alternative splicing: 2 isoforms:  O00470-1   O00470-2   

Explore the universe of human proteins at neXtProt for MEIS1: NX_O00470

Explore proteomics data for MEIS1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MEIS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002389.1  
    ENSEMBL proteins: 
     ENSP00000454209   ENSP00000475875   ENSP00000272369   ENSP00000475161   ENSP00000381518  
     ENSP00000440571   ENSP00000386514   ENSP00000397418   ENSP00000476169   ENSP00000475982  
     ENSP00000475692   ENSP00000475222   ENSP00000395827   ENSP00000384461   ENSP00000403206  

    MEIS1 Human Recombinant Protein Products:

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    Novus Biologicals MEIS1 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MEIS1

     
    Search eBioscience for Proteins for MEIS1 

    MEIS1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for MEIS1

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    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for MEIS1
    Cloud-Clone Corp. CLIAs for MEIS1
    Search eBioscience for ELISAs for MEIS1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TALE: Homeoboxes / TALE class

    3 InterPro protein domains:
     IPR008422 Homeobox_KN_domain
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry O00470

    ProtoNet protein and cluster: O00470

    UniProtKB/Swiss-Prot: MEIS1_HUMAN, O00470
    Similarity: Belongs to the TALE/MEIS homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with MEIS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MEIS1_HUMAN, O00470
    Function: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with
    PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function
    as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias

         Genatlas biochemistry entry for MEIS1:
    homeo domain protein,unusual,murine Meis1 (myeloid ecotropic viral integration site 1) ortholog,expressed in fetal
    liver,normal immunohematopoietic tissues and cerebellum,binding DNA cooperatively with the heterodimer
    E2A/myogenic transcription factors

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity ----
    GO:0005515protein binding IPI18692240
         
    Find genes that share ontologies with MEIS1           About GenesLikeMe


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Meis1):
     cardiovascular system  cellular  hematopoietic system  integument  limbs/digits/tail 
     liver/biliary system  mortality/aging  nervous system  renal/urinary system  respiratory system 
     vision/eye 

    Find genes that share phenotypes with MEIS1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MEIS1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MEIS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MEIS1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MEIS1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MEIS1:
    hsa-let-7a-5p (MIRT004962), hsa-mir-155-5p (MIRT000287), hsa-mir-101-3p (MIRT027307), hsa-mir-204-5p (MIRT000189), hsa-mir-98-5p (MIRT004946), hsa-mir-21-5p (MIRT030714), hsa-mir-495-3p (MIRT007195), hsa-mir-484 (MIRT041845)

    Block miRNA regulation of human, mouse, rat MEIS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MEIS1 (see all 112):
    hsa-miR-607 hsa-miR-3938 hsa-miR-300 hsa-miR-374a hsa-miR-371-5p hsa-miR-10b* hsa-miR-208b hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidMEIS1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MEIS1
    Predesigned siRNA for gene silencing in human, mouse, rat MEIS1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for MEIS1

    Clone
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    OriGene clones in human, mouse for MEIS1 (see all 7)
    OriGene ORF clones in mouse, rat for MEIS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MEIS1 (NM_002398)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEIS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEIS1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MEIS1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEIS1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MEIS1_HUMAN, O00470: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex ----

    Find genes that share ontologies with MEIS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MEIS1 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional Regulatory Network in Embryonic Stem Cell
    Transcriptional Regulatory Network in Embryonic Stem Cell
    2Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer


    Find genes that share SuperPaths with MEIS1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MEIS1
        Transcriptional Regulatory Network in Embryonic Stem Cell


    1 Kegg Pathway  (Kegg details for MEIS1):
        Transcriptional misregulation in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MEIS1: 
              Leukemia in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MEIS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MEIS1 (O004701, 3 ENSP000002723694) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206315P404253I2D: score=2 
    ENSG00000224952P404253I2D: score=2 
    ENSG00000225987P404253I2D: score=2 
    ENSG00000232005P404253I2D: score=2 
    ENSG00000236353P404253I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis ----
    GO:0002089lens morphogenesis in camera-type eye ----
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007275multicellular organismal development IEA--

    Find genes that share ontologies with MEIS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MEIS1

    1 HMDB Compound for MEIS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    3 Novoseek inferred chemical compound relationships for MEIS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arsenite 27 1 11133770 (1)
    retinoic acid 22.5 1 11133770 (1)
    tyrosine 0 3 15755900 (2), 19514512 (1)



    Find genes that share compounds with MEIS1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MEIS1 gene: 
    NM_002398.2  

    Unigene Cluster for MEIS1:

    Meis homeobox 1
    Hs.526754  [show with all ESTs]
    Unigene Representative Sequence: CR749827
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000496248 ENST00000560281 ENST00000491706 ENST00000272369(uc002sdu.3 uc010yqi.2)
    ENST00000488550(uc002sdt.3) ENST00000490726 ENST00000398506 ENST00000495021(uc002sdw.1)
    ENST00000409622 ENST00000437869 ENST00000466811 ENST00000498705 ENST00000606455
    ENST00000475239 ENST00000409517 ENST00000542964 ENST00000450027 ENST00000407092(uc010yqh.2)

    miRNA
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    Block miRNA regulation of human, mouse, rat MEIS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MEIS1 (see all 112):
    hsa-miR-607 hsa-miR-3938 hsa-miR-300 hsa-miR-374a hsa-miR-371-5p hsa-miR-10b* hsa-miR-208b hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidMEIS1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MEIS1
    Predesigned siRNA for gene silencing in human, mouse, rat MEIS1
    Clone
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    OriGene ORF clones in mouse, rat for MEIS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MEIS1 (NM_002398)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEIS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEIS1
    Primer
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    OriGene qPCR primer pairs and template standards for MEIS1
    OriGene qSTAR qPCR primer pairs in human, mouse for MEIS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MEIS1
      QuantiTect SYBR Green Assays in human, mouse, rat MEIS1
      QuantiFast Probe-based Assays in human, mouse, rat MEIS1

    Additional mRNA sequence: 

    AK098174.1 AK297109.1 AK297817.1 AK314949.1 BC043503.1 BX648626.1 CR749827.1 U85707.1 

    16 DOTS entries:

    DT.95147812  DT.100780375  DT.100647990  DT.452959  DT.99995176  DT.102832068  DT.91868493  DT.86853769 
    DT.120951306  DT.120951310  DT.120951322  DT.120951343  DT.40264477  DT.95263413  DT.99927451  DT.208558 

    Selected AceView cDNA sequences (see all 149):

    AA600354 CB216927 AA373202 AA976262 CB215310 AI648608 BM663955 BG502562 
    AK098174 AW452245 AI669255 AI968410 AA035599 AW243936 CR612956 U85707 
    AA081754 CA867974 BU618932 BX119044 CB854199 BF057538 BG501632 BM014915 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MEIS1 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^
    SP1:              -           -           -     -           -                 -                 -                                               -               
    SP2:              -           -           -     -           -                 -                 -                                                               
    SP3:                                                        -                 -                 -                                               -               
    SP4:                          -           -     -           -                 -                 -                                                               
    SP5:                                                                                                                                                            

    ExUns: 18a · 18b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for MEIS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MEIS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGTATTTT
    MEIS1 Expression
    About this image


    MEIS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Progress Zone Cells Limb Bud
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Progress Zone Cells Limb Bud
             Zeugopod Epiphyseal End
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Progress Zone Cells Limb Bud
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Thalamus
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
    MEIS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MEIS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.526754

    UniProtKB/Swiss-Prot: MEIS1_HUMAN, O00470
    Tissue specificity: Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver.
    Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a
    megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MEIS1: 
              Leukemia in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MEIS1
    QuantiTect SYBR Green Assays in human, mouse, rat MEIS1
    QuantiFast Probe-based Assays in human, mouse, rat MEIS1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEIS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MEIS1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Meis15 Meis homeobox 1   --   11 (11.11 cM) 18880430 
    chicken
    (Gallus gallus)
    Aves MEIS11 Meis homeobox 1 88.21(n)
    96.92(a)
      395589  NM_001139477.1  NP_001132949.1 
    lizard
    (Anolis carolinensis)
    Reptilia MEIS16
    Meis homeobox 1
    76(a)
    1 ↔ 1
    1(125268756-125437201)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.6072 Xenopus laevis XMeis1-4 protein mRNA, partial cds 83.58(n)    U68387.1 
    zebrafish
    (Danio rerio)
    Actinopterygii meis12 myeloid ecotropic viral integration 1 82.25(n)   170446  AF375871.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta hth3 brain development transcription factor 51(a)     --


    ENSEMBL Gene Tree for MEIS1 (if available)
    TreeFam Gene Tree for MEIS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MEIS1 gene
    MEIS22  TGIF2LY2  PKNOX12  MEIS32  TGIF22  PKNOX22  TGIF2LX2  TGIF12  
    12 SIMAP similar genes for MEIS1 using alignment to 15 protein entries:     MEIS1_HUMAN (see all proteins):
    meis1    HB103    MEIS2    MEIS3P1    MEIS3    MEIS3P2
    TGIF1    TGIF2    PKNOX2    PKNOX1    TGIF2LY    WUGSC

    Find genes that share paralogs with MEIS1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MEIS1 (see all 2468)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs126150051,2
    C,H--66401580(+) tttttA/Tctttt 1 -- int1 trp31Minor allele frequency- T:0.00NA 2
    rs101658541,2
    C--66429860(+) GAGGTG/AGGGGG 1 -- int11Minor allele frequency- A:0.00CSA 1
    rs1475384091,2
    C--66429860(+) GAGGT-/A/G/GG
            
    GGGGG
    1 -- int10--------
    rs1459886481,2
    C--66440352(+) TCTTC-/AAGATT 1 -- int10--------
    rs1386627371,2
    C--66442418(+) CAATG-/CCACTG 1 -- int10--------
    rs1483556681,2
    C--66453586(+) AAAAA-/AGAGAGA 1 -- int10--------
    rs788666781,2
    C--66496983(+) TGTTTC/TCCTTT 1 -- int10--------
    rs3695254991,2
    C--66524491(+) TTTTA-/AC/T  
     TTTTTTT
    CTTTT
    1 -- int10--------
    rs1488577761,2
    --66526649(+) TGGCAA/GTTCGC 1 -- us2k10--------
    rs1162481561,2
    F--66527115(+) CAGTGG/ATTGGT 1 -- us2k11Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for MEIS1 (66660584 - 66801001 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MEIS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834248CNV Gain17160897

    Human Gene Mutation Database (HGMD): MEIS1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MEIS1
    DNA2.0 Custom Variant and Variant Library Synthesis for MEIS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601739    OMIM disorders: --

    UniProtKB/Swiss-Prot: MEIS1_HUMAN, O00470
  • Restless legs syndrome 7 (RLS7) [MIM:612853]: A neurologic sleep/wake disorder characterized by
    uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an
    irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation.
    The majority of patients also have periodic limb movements in sleep, which are characterized by involuntary,
    highly stereotypical, regularly occurring limb movements that occur during sleep. Note=Disease susceptibility may
    be associated with variations affecting the gene represented in this entry

  • 2 diseases for MEIS1:    
    About MalaCards
    collagen type vi-related disorders    acute myeloid leukemia

    1 disease from the University of Copenhagen DISEASES database for MEIS1:
    Leukemia

    Find genes that share disorders with MEIS1           About GenesLikeMe

    9 Novoseek inferred disease relationships for MEIS1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemogenesis 82.3 11 16648484 (3), 15755900 (3), 9226379 (1), 15681849 (1) (see all 7)
    myeloid leukemia 71 8 9226379 (2), 17202314 (1), 10996203 (1), 14713950 (1) (see all 7)
    leukemia 67.3 39 19109563 (7), 16469876 (3), 15755900 (3), 11161815 (2) (see all 16)
    acute leukemia 40 2 10996203 (1), 15160920 (1)
    leukemia promyelocytic acute 39.3 1 11133770 (1)
    lymphoblastic leukemia acute 30.8 1 11314021 (1)
    myeloid leukemia chronic 23.5 1 10602420 (1)
    cancer 6.25 5 17949970 (2), 11704843 (1), 11161815 (1), 15755900 (1)
    tumors 0 7 7565694 (2), 19825192 (2)

    Genetic Association Database (GAD): MEIS1
    Human Genome Epidemiology (HuGE) Navigator: MEIS1 (13 documents)

    Export disorders for MEIS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MEIS1 gene, integrated from 10 sources (see all 143):
    (articles sorted by number of sources associating them with MEIS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels. (PubMed id 19126776)1, 4, 9 Xiong L....Rouleau G.A. (Hum. Mol. Genet. 2009)
    2. Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. (PubMed id 7565694)1, 3, 9 Moskow J.J....Buchberg A.M. (Mol. Cell. Biol. 1995)
    3. Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene. (PubMed id 12609849)1, 2, 9 Okada Y....Doi T. (Blood 2003)
    4. Cloning and mapping of the MEIS1 gene, the human homolog of a murine leukemogenic gene. (PubMed id 9226379)1, 2, 9 Smith J.E. Jr.... Takeshita K. (Genomics 1997)
    5. Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. (PubMed id 21779176)1, 4 Winkelmann J....Meitinger T. (PLoS Genet. 2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Genome-wide association study of PR interval. (PubMed id 20062060)1, 4 Pfeufer A....Heckbert S.R. (Nat. Genet. 2010)
    9. Exploring the genetic link between RLS and ADHD. (PubMed id 19223043)1, 4 Schimmelmann B.G....Hebebrand J. (J Psychiatr Res 2009)
    10. Association of intronic variants of the BTBD9 gene with Tourette syndrome. (PubMed id 19822783)1, 4 RiviA"re J.B....Rouleau G.A. (Arch. Neurol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4211 HGNC: 7000 AceView: MEIS1 Ensembl:ENSG00000143995 euGenes: HUgn4211
    ECgene: MEIS1 Kegg: 4211 H-InvDB: MEIS1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MEIS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MEIS1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MEIS1 gene:
    Search GeneIP for patents involving MEIS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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