Aliases for MEIS1 Gene
External Ids for MEIS1 Gene
Previous GeneCards Identifiers for MEIS1 Gene
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for MEIS1 Gene
MEIS1 (Meis Homeobox 1) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer and Transcriptional Regulatory Network in Embryonic Stem Cell. GO annotations related to this gene include sequence-specific DNA binding and chromatin binding. An important paralog of this gene is TGIF2LY.
UniProtKB/Swiss-Prot for MEIS1 Gene
Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.