Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MEIOC Gene

Aliases for MEIOC Gene

  • Meiosis Specific With Coiled-Coil Domain 2 3 5
  • Meiosis-Specific With Coiled-Coil Domain Protein 3 4
  • C17orf104 3 4
  • Meiosis-Specific Coiled-Coil Domain-Containing Protein MEIOC 3
  • Chromosome 17 Open Reading Frame 104 2

External Ids for MEIOC Gene

Previous HGNC Symbols for MEIOC Gene

  • C17orf104

Summaries for MEIOC Gene

GeneCards Summary for MEIOC Gene

MEIOC (Meiosis Specific With Coiled-Coil Domain) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MEIOC Gene

  • Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle.

Additional gene information for MEIOC Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEIOC Gene

Genomics for MEIOC Gene

GeneHancer (GH) Regulatory Elements for MEIOC Gene

Promoters and enhancers for MEIOC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I044656 Promoter 0.9 EPDnew 550.8 +0.1 55 0.1 CTCF KLF1 MAZ SP3 L3MBTL2 ZNF189 SIN3A POLR2A PATZ1 EZH2 MEIOC ENSG00000267160
GH17I044687 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.3 +33.0 33045 3.7 CLOCK FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 ENSG00000279879 CCDC43 DBF4B TMUB2 UBTF ASB16-AS1 GPATCH8 ENSG00000224505 ENSG00000260793 MEIOC
GH17I044541 Enhancer 1.8 VISTA FANTOM5 Ensembl ENCODE dbSUPER 11.3 -111.2 -111180 8.1 HDGF SIN3A ETS1 TCF12 GLIS2 ZNF143 FOS ATF7 REST SMARCA4 GPATCH8 MEIOC FAM171A2 SLC25A39 TMUB2 FZD2 GRN ADAM11 TMEM101 GJC1
GH17I044533 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.4 -122.4 -122412 1.7 HDGF CLOCK ARID4B SIN3A GLI4 ZNF2 ZNF48 SLC30A9 ZNF121 GLIS2 GPATCH8 MEIOC CCDC43 LOC105371791 PIR44449
GH17I044818 Enhancer 1.4 Ensembl ENCODE dbSUPER 9.8 +164.0 164001 3.4 ARNT ZNF493 ZFP64 FEZF1 ZNF2 ZNF121 ZNF213 KLF7 FOS ZNF202 UBTF ASB16-AS1 TMUB2 GPATCH8 GJC1 MPP2 ENSG00000266918 LINC02210 ENSG00000260793 EFTUD2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MEIOC on UCSC Golden Path with GeneCards custom track

Genomic Locations for MEIOC Gene

Genomic Locations for MEIOC Gene
chr17:44,656,394-44,690,308
(GRCh38/hg38)
Size:
33,915 bases
Orientation:
Plus strand
chr17:42,733,762-42,767,676
(GRCh37/hg19)

Genomic View for MEIOC Gene

Genes around MEIOC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEIOC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEIOC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEIOC Gene

Proteins for MEIOC Gene

  • Protein details for MEIOC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RUB1-MEIOC_HUMAN
    Recommended name:
    Meiosis-specific coiled-coil domain-containing protein MEIOC
    Protein Accession:
    A2RUB1
    Secondary Accessions:
    • B4DXJ2
    • B5MD93
    • B9EGQ6
    • C4AM97
    • Q4G0Y1
    • Q8IVZ7
    • Q8NA45

    Protein attributes for MEIOC Gene

    Size:
    952 amino acids
    Molecular mass:
    107559 Da
    Quaternary structure:
    • Interacts with YTHDC2; binds transcript that regulate the mitotic cell cycle inhibiting progression into metaphase, thereby allowing meiotic prophase to proceed normally.
    SequenceCaution:
    • Sequence=AAH35159.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI32823.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI36643.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MEIOC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEIOC Gene

Post-translational modifications for MEIOC Gene

No Post-translational modifications

Other Protein References for MEIOC Gene

No data available for DME Specific Peptides for MEIOC Gene

Domains & Families for MEIOC Gene

Gene Families for MEIOC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MEIOC Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MEIOC: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MEIOC Gene

Function for MEIOC Gene

Molecular function for MEIOC Gene

UniProtKB/Swiss-Prot Function:
Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle.
genes like me logo Genes that share phenotypes with MEIOC: view

Animal Models for MEIOC Gene

MGI Knock Outs for MEIOC:

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEIOC Gene

Localization for MEIOC Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEIOC Gene

Cytoplasm. Nucleus. Note=at late pachytene a fraction is nuclear. {ECO:0000250 UniProtKB:A2AG06}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEIOC gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MEIOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with MEIOC: view

Pathways & Interactions for MEIOC Gene

SuperPathways for MEIOC Gene

No Data Available

Interacting Proteins for MEIOC Gene

Gene Ontology (GO) - Biological Process for MEIOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006302 double-strand break repair IEA --
GO:0007130 synaptonemal complex assembly IEA --
GO:0007141 male meiosis I IEA --
GO:0007144 female meiosis I IEA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with MEIOC: view

No data available for Pathways by source and SIGNOR curated interactions for MEIOC Gene

Drugs & Compounds for MEIOC Gene

No Compound Related Data Available

Transcripts for MEIOC Gene

Alternative Splicing Database (ASD) splice patterns (SP) for MEIOC Gene

No ASD Table

Relevant External Links for MEIOC Gene

GeneLoc Exon Structure for
MEIOC
ECgene alternative splicing isoforms for
MEIOC

Expression for MEIOC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of MEIOC Gene:

MEIOC

mRNA Expression by UniProt/SwissProt for MEIOC Gene:

A2RUB1-MEIOC_HUMAN
Tissue specificity: Expressed in fetal ovaries (PubMed:26742488). Expressed in testis (PubMed:28380054).

Evidence on tissue expression from TISSUES for MEIOC Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with MEIOC: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEIOC Gene

Orthologs for MEIOC Gene

This gene was present in the common ancestor of animals.

Orthologs for MEIOC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf104 33
  • 99.54 (n)
C17orf104 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C9H17orf104 33
  • 92.69 (n)
C17orf104 34
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C19H17orf104 33
  • 92.29 (n)
C17orf104 34
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1563746 33
  • 90.71 (n)
mouse
(Mus musculus)
Mammalia Gm1564 33 34
  • 90.61 (n)
Meioc 16
oppossum
(Monodelphis domestica)
Mammalia C17orf104 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C17orf104 34
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves C27H17ORF104 33
  • 67.91 (n)
C17orf104 34
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C17orf104 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496184 33
  • 56.51 (n)
zebrafish
(Danio rerio)
Actinopterygii C17orf104 34
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y39A1A.9 34
  • 26 (a)
OneToOne
Species where no ortholog for MEIOC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEIOC Gene

ENSEMBL:
Gene Tree for MEIOC (if available)
TreeFam:
Gene Tree for MEIOC (if available)

Paralogs for MEIOC Gene

No data available for Paralogs for MEIOC Gene

Variants for MEIOC Gene

Sequence variations from dbSNP and Humsavar for MEIOC Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000018918 -- 44,669,855(+) A/C intron_variant
rs1000057692 -- 44,659,803(+) C/T intron_variant
rs1000108245 -- 44,659,228(+) A/G intron_variant
rs1000313568 -- 44,677,227(+) T/C downstream_transcript_variant
rs1000377619 -- 44,667,273(+) T/C coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for MEIOC Gene

Variant ID Type Subtype PubMed ID
nsv112452 CNV deletion 16902084
nsv1146669 OTHER inversion 26484159
nsv575100 CNV loss 21841781
nsv828020 CNV gain 20364138
nsv833456 CNV gain+loss 17160897

Variation tolerance for MEIOC Gene

Residual Variation Intolerance Score: 63.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.51; 77.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEIOC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEIOC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEIOC Gene

Disorders for MEIOC Gene

No disorders were found for MEIOC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEIOC Gene

Publications for MEIOC Gene

  1. Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts. (PMID: 26742488) Abby E … Livera G (Nature communications 2016) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Meioc maintains an extended meiotic prophase I in mice. (PMID: 28380054) Soh YQS … Page DC (PLoS genetics 2017) 4 58
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 58

Products for MEIOC Gene

Sources for MEIOC Gene

Content
Loading form....