Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MEIOB Gene

Aliases for MEIOB Gene

  • Meiosis Specific With OB Domains 2 3 5
  • C16orf73 3 4
  • Chromosome 16 Open Reading Frame 73 2
  • EC 3.1.-.- 4
  • Gs129 3

External Ids for MEIOB Gene

Previous HGNC Symbols for MEIOB Gene

  • C16orf73

Previous GeneCards Identifiers for MEIOB Gene

  • GC16M001884
  • GC16M001886

Summaries for MEIOB Gene

GeneCards Summary for MEIOB Gene

MEIOB (Meiosis Specific With OB Domains) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and single-stranded DNA 3-5 exodeoxyribonuclease activity.

UniProtKB/Swiss-Prot for MEIOB Gene

  • Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3-5 exonuclease activity in vitro (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEIOB Gene

Genomics for MEIOB Gene

Genomic Location for MEIOB Gene

Chromosome:
16
Start:
1,833,983 bp from pter
End:
1,884,294 bp from pter
Size:
50,312 bases
Orientation:
Minus strand

Genomic View for MEIOB Gene

Genes around MEIOB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEIOB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEIOB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEIOB Gene

No data available for Regulatory Elements for MEIOB Gene

Proteins for MEIOB Gene

  • Protein details for MEIOB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N635-MEIOB_HUMAN
    Recommended name:
    Meiosis-specific with OB domain-containing protein
    Protein Accession:
    Q8N635
    Secondary Accessions:
    • B1AK39
    • C9J0S1
    • Q96RY0

    Protein attributes for MEIOB Gene

    Size:
    442 amino acids
    Molecular mass:
    49313 Da
    Quaternary structure:
    • Component of a multiprotein complex with RPA2 and SPATA22.
    SequenceCaution:
    • Sequence=AAH29829.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK61296.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MEIOB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEIOB Gene

Proteomics data for MEIOB Gene at MOPED

Post-translational modifications for MEIOB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MEIOB Gene

No data available for DME Specific Peptides for MEIOB Gene

Domains & Families for MEIOB Gene

Protein Domains for MEIOB Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8N635

UniProtKB/Swiss-Prot:

MEIOB_HUMAN :
  • Contains 1 OB DNA-binding domain.
  • Belongs to the MEIOB family.
Domain:
  • Contains 1 OB DNA-binding domain.
Family:
  • Belongs to the MEIOB family.
genes like me logo Genes that share domains with MEIOB: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MEIOB Gene

Function for MEIOB Gene

Molecular function for MEIOB Gene

UniProtKB/Swiss-Prot Function:
Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3-5 exonuclease activity in vitro (By similarity).

Enzyme Numbers (IUBMB) for MEIOB Gene

Gene Ontology (GO) - Molecular Function for MEIOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding IEA,ISS --
GO:0008310 single-stranded DNA 3-5 exodeoxyribonuclease activity IEA,ISS --
genes like me logo Genes that share ontologies with MEIOB: view
genes like me logo Genes that share phenotypes with MEIOB: view

Animal Models for MEIOB Gene

MGI Knock Outs for MEIOB:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MEIOB Gene

Localization for MEIOB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEIOB Gene

Cytoplasm. Nucleus. Chromosome. Note=Co-localizes with the RPA complex on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on SPATA22 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEIOB Gene COMPARTMENTS Subcellular localization image for MEIOB gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for MEIOB Gene

Pathways & Interactions for MEIOB Gene

SuperPathways for MEIOB Gene

No Data Available

Interacting Proteins for MEIOB Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000314484%0d%0a9606.ENSP00000260983%0d%0a
Selected Interacting proteins: ENSP00000314484 for MEIOB Gene via STRING

Symbol External ID(s) Details
HECW2

Gene Ontology (GO) - Biological Process for MEIOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000712 resolution of meiotic recombination intermediates ISS --
GO:0007129 synapsis IEA,ISS --
GO:0007140 male meiosis IEA,ISS --
GO:0007141 male meiosis I IEA --
GO:0007144 female meiosis I IEA,ISS --
genes like me logo Genes that share ontologies with MEIOB: view

No data available for Pathways by source and SIGNOR curated interactions for MEIOB Gene

Drugs & Compounds for MEIOB Gene

No Compound Related Data Available

Transcripts for MEIOB Gene

mRNA/cDNA for MEIOB Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MEIOB Gene

Meiosis specific with OB domains:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEIOB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP2:
SP3:
SP4: - -
SP5:

Relevant External Links for MEIOB Gene

GeneLoc Exon Structure for
MEIOB
ECgene alternative splicing isoforms for
MEIOB

Expression for MEIOB Gene

mRNA expression in normal human tissues for MEIOB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEIOB Gene

This gene is overexpressed in Testis (x41.9).

Protein differential expression in normal tissues from HIPED for MEIOB Gene

This gene is overexpressed in Urinary Bladder (46.9), Testis (6.5), and Adrenal (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MEIOB Gene



SOURCE GeneReport for Unigene cluster for MEIOB Gene Hs.729604

mRNA Expression by UniProt/SwissProt for MEIOB Gene

Q8N635-MEIOB_HUMAN
Tissue specificity: In fetal gonads, specifically expressed in the ovary starting at the 14th weeks post fertilization.
genes like me logo Genes that share expression patterns with MEIOB: view

Protein tissue co-expression partners for MEIOB Gene

Primer Products

In Situ Assay Products

Orthologs for MEIOB Gene

This gene was present in the common ancestor of animals.

Orthologs for MEIOB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEIOB 36
  • 99 (a)
OneToOne
LOC750018 35
  • 99.54 (n)
  • 99.54 (a)
cow
(Bos Taurus)
Mammalia MEIOB 35
  • 88.54 (n)
  • 85.75 (a)
MEIOB 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEIOB 36
  • 85 (a)
OneToOne
MEIOB 35
  • 87.47 (n)
  • 85.56 (a)
mouse
(Mus musculus)
Mammalia Meiob 16
Meiob 36
  • 84 (a)
OneToOne
Meiob 35
  • 86.78 (n)
  • 84.86 (a)
oppossum
(Monodelphis domestica)
Mammalia MEIOB 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEIOB 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Meiob 35
  • 85.57 (n)
  • 83.58 (a)
chicken
(Gallus gallus)
Aves C14H16ORF73 35
  • 73.06 (n)
  • 69.72 (a)
MEIOB 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEIOB 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia meiob 35
  • 68.16 (n)
  • 65.02 (a)
zebrafish
(Danio rerio)
Actinopterygii meiob 35
  • 58.91 (n)
  • 51.66 (a)
meiob 36
  • 49 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011538 35
  • 40.02 (n)
  • 31.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta hdm 35
  • 40.3 (n)
  • 29.21 (a)
hdm 36
  • 24 (a)
OneToOne
Species with no ortholog for MEIOB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEIOB Gene

ENSEMBL:
Gene Tree for MEIOB (if available)
TreeFam:
Gene Tree for MEIOB (if available)

Paralogs for MEIOB Gene

(1) SIMAP similar genes for MEIOB Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MEIOB: view

No data available for Paralogs for MEIOB Gene

Variants for MEIOB Gene

Sequence variations from dbSNP and Humsavar for MEIOB Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs9806945 - 1,844,960(+) CTGGT(A/G)TATCT reference, missense
rs1657125 - 1,862,020(+) GAGAC(G/T)TGATG reference, missense
rs1742446 - 1,868,124(+) ATTTG(G/T)CTGCA reference, missense
rs378201 -- 1,865,033(+) AATCT(C/G)ATCAC intron-variant
rs388928 -- 1,859,656(-) ACTCT(C/G)AAGCC intron-variant

Variation tolerance for MEIOB Gene

Gene Damage Index Score: 9.71; 89.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEIOB Gene

HapMap Linkage Disequilibrium report
MEIOB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MEIOB Gene

Disorders for MEIOB Gene

Relevant External Links for MEIOB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEIOB

No disorders were found for MEIOB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEIOB Gene

Publications for MEIOB Gene

  1. MEIOB targets single-strand DNA and is necessary for meiotic recombination. (PMID: 24068956) Souquet B. … Livera G. (PLoS Genet. 2013) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PMID: 24163370) Lu L. … Zhang L. (J. Biol. Chem. 2013) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for MEIOB Gene

Sources for MEIOB Gene

Back to Top

Content