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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MEIOB Gene

protein-coding   GIFtS: 37
GCID: GC16M001884

Meiosis Specific With OB Domains

(Previous name: chromosome 16 open reading frame 73)
(Previous symbol: C16orf73)
  Search for MEIOB
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Meiosis Specific With OB Domains1 2
C16orf731 2 3
Chromosome 16 Open Reading Frame 731
gs1292
Meiosis-Specific With OB Domain-Containing Protein2

External Ids:    HGNC: 285691   Entrez Gene: 2545282   Ensembl: ENSG000001620397   UniProtKB: Q8N6353   

Export aliases for MEIOB gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MEIOB Gene: 
MEIOB (meiosis specific with OB domains) is a protein-coding gene.

UniProtKB/Swiss-Prot: MEIOB_HUMAN, Q8N635
Function: May be involved in early meiosis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MEIOB
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MEIOB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEIOB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

MEIOB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEIOB gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M001884:  view genomic region     (about GC identifiers)

Start:
1,883,984 bp from pter      End:
1,934,295 bp from pter
Size:
50,312 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MEIOB_HUMAN, Q8N635 (See protein sequence)
Recommended Name: Meiosis-specific with OB domain-containing protein  
Size: 442 amino acids; 49313 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAH29829.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAK61296.1; Type=Erroneous gene model prediction;
Secondary accessions: B1AK39 C9J0S1 Q96RY0
Alternative splicing: 2 isoforms:  Q8N635-1   Q8N635-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MEIOB: NX_Q8N635

Explore proteomics data for MEIOB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N635

  • MEIOB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MEIOB Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001157032.1  NP_689977.2  

    ENSEMBL proteins: 
     ENSP00000457416   ENSP00000314484   ENSP00000380504   ENSP00000456880   ENSP00000457427  
     ENSP00000390778   ENSP00000391033  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--

    MEIOB for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR012340 NA-bd_OB-fold

    Graphical View of Domain Structure for InterPro Entry Q8N635

    ProtoNet protein and cluster: Q8N635


    MEIOB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MEIOB_HUMAN, Q8N635
    Function: May be involved in early meiosis (By similarity)

    Animal Models:

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MEIOB

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007140male meiosis ISS--

    MEIOB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MEIOB

    Search CenterWatch for drugs/clinical trials and news about MEIOB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MEIOB gene (2 alternative transcripts): 
    NM_001163560.2  NM_152764.2  

    Unigene Cluster for MEIOB:

    Meiosis specific with OB domains
    Hs.729604  [show with all ESTs]
    Unigene Representative Sequence: NM_001163560
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470044(uc010uvr.2) ENST00000325962 ENST00000397344 ENST00000490154
    ENST00000496541 ENST00000460494 ENST00000563416(uc021tal.1) ENST00000412554(uc010uvq.1 uc002cne.2)
    ENST00000452149
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    Inhib. RNA
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    Additional mRNA sequence: BC029829.1 

    4 DOTS entries:

    DT.40126988  DT.92009187  DT.92069014  DT.75108373 

    4 AceView cDNA sequences:

    BC029829 NM_152764 BG193877 BG187699 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MEIOB    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                                                -         
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:        -     -                                                                           
    SP5:                                                                                          


    ECgene alternative splicing isoforms for MEIOB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    MEIOB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             XX Germ Cells Ovigerous Cord
             Ovigerous Cord
     
     Kidney (Reproductive System)
             visceral organ/mesonephros of male/mesonephric tubule of male   
     
     Gonad
             XX Germ Cells Ovigerous Cord
     
     Testis (Reproductive System)

    See MEIOB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MEIOB

    SOURCE GeneReport for Unigene cluster: Hs.729604
        SABiosciences Custom PCR Arrays for MEIOB
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEIOB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MEIOB gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Meiob1 , 5 RIKEN cDNA 4930528F23 gene5
    meiosis specific with OB domains1
    86.78(n)1
    84.86(a)1
      17 (12.53 cM)5
    751781  NM_029197.11  NP_083473.11 
     248043825 
    chicken
    (Gallus gallus)
    Aves MEIOB1 meiosis specific with OB domains 73.41(n)
    70.89(a)
      416539  XM_414840.3  XP_414840.3 
    lizard
    (Anolis carolinensis)
    Reptilia MEIOB6
    Uncharacterized protein
    70(a)
    1 ↔ 1
    GL343263.1(1368304-1379303)
    zebrafish
    (Danio rerio)
    Actinopterygii MEIOB6
    meiosis specific with OB domains
    49(a)
    1 ↔ 1
    12(19558831-19569691)
    fruit fly
    (Drosophila melanogaster)
    Insecta hdm1 hold'em 40.08(n)
    28.05(a)
      31705  NM_132194.1  NP_572422.1 


    ENSEMBL Gene Tree for MEIOB (if available)
    TreeFam Gene Tree for MEIOB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MEIOB gene
    1 SIMAP similar gene for MEIOB using alignment to 4 protein entries:     MEIOB_HUMAN (see all proteins):
    C16orf73

    MEIOB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/937 SNPs in MEIOB are shown (see all 937)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs25753551,2
    C--1849068(+) caaagT/Gttgca 1 -- us2k17Minor allele frequency- G:0.07NA WA 14
    rs118639401,2
    C,F,H--1890793(+) tgatcT/Cacctg 2 -- int11Minor allele frequency- C:0.00NA 2
    rs620384251,2
    C,F--1890841(+) CCACCG/ACGCCC 2 -- int12Minor allele frequency- A:0.50NA WA 4
    rs1874940531,2
    --1890843(+) ACCACA/GCCCAG 2 -- int10--------
    rs1390145851,2
    --1890997(+) GGAGT-/TTAC  
            
    TTTCT
    2 -- int10--------
    rs615053581,2
    F--1891019(+) TTTTTC/TTTTTT 2 -- int11Minor allele frequency- T:0.50NA 4
    rs1929608871,2
    --1891049(+) TTTCAC/TTCTTC 2 -- int10--------
    rs1499234661,2
    C--1891096(+) CACCGC/TGACCT 2 -- int10--------
    rs116428941,2
    H--1891162(+) acaggG/Tgcccg 2 -- int10--------
    rs558298671,2
    C--1891166(+) GTGCCC/TGCCAC 2 -- int11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for MEIOB (1883984 - 1934295 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MEIOB: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MEIOB
    DNA2.0 Custom Variant and Variant Library Synthesis for MEIOB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MEIOB gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MEIOB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (2001)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    4. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 254528 HGNC: 28569 AceView: MGC35212 Ensembl:ENSG00000162039 euGenes: HUgn254528
    ECgene: MEIOB H-InvDB: MEIOB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MEIOB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MEIOB gene:
    Search GeneIP for patents involving MEIOB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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