MEIG1 Gene
protein-coding GIFtS: 40
GCID: GC10P015001
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Meiosis/Spermiogenesis Associated 1(Previous name: meiosis expressed gene 1 homolog (mouse))
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Aliases
for MEIG1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
|---|
| Meiosis/Spermiogenesis Associated 11 2 | | bA2K17.32 | | Spermatogenesis Associated 391 2 | | Meiosis Expressed Gene 1 Homolog2 | | Meiosis Expressed Gene 1 Homolog (Mouse)1 | | Meiosis Expressed Gene 1 Protein Homolog2 | | SPATA392 | | |
Export aliases for MEIG1 gene to outside databasesPrevious GC identifers: GC10U900466 GC10P015042 GC10P014911 |
Summaries
for MEIG1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
GeneCards Summary for MEIG1 Gene: 
MEIG1 (meiosis/spermiogenesis associated 1) is a protein-coding gene. Diseases associated with MEIG1 include omenn syndrome, and premature ovarian failure.
UniProtKB/Swiss-Prot: MEIG1_HUMAN, Q5JSS6Function: Essential for spermiogenesis (By similarity)
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Genomic Views
for MEIG1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NT_008705.16 NC_018921.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MEIG1 gene promoter:
p53 Egr-1 Tal-1beta ITF-2 Evi-1 FOXL1 YY1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MEIG1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEIG1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p13 Ensembl cytogenetic band: 10p13 HGNC cytogenetic band: 10p13MEIG1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P015001: view genomic region
(about GC identifiers)
Start:
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15,001,438 bp from pter |
End:
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15,030,049 bp from pter |
Size:
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28,612 bases |
Orientation:
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plus strand |
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Proteins
for MEIG1 gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
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UniProtKB/Swiss-Prot: MEIG1_HUMAN, Q5JSS6 (See
protein sequence)Recommended Name: Meiosis expressed gene 1 protein homolog Size: 88 amino acids; 10795 Da
Subunit: Interacts with PACRG (By similarity)Explore the universe of human proteins at neXtProt for MEIG1: NX_Q5JSS6
Explore proteomics data for MEIG1 at MOPED
MEIG1 Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : About this image 
REFSEQ proteins: NP_001074305.1
ENSEMBL proteins: ENSP00000367486 ENSP00000384334
Human Recombinant Protein Products for MEIG1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005634 | nucleus |
IEA | -- |
MEIG1 for ontologies About GeneDecksing
MEIG1 Antibody Products:
Assay Products for MEIG1: |
Protein
Domains /
Families
for MEIG1 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| 1 InterPro protein domain:Graphical View of Domain Structure for InterPro Entry Q5JSS6 ProtoNet protein and cluster: Q5JSS6 UniProtKB/Swiss-Prot: MEIG1_HUMAN, Q5JSS6Similarity: Belongs to the MEIG1 family
MEIG1 for domains About GeneDecksing
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Function
for MEIG1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
Vector BioLabs,
and Sirion Biotech,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
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Molecular Function:
UniProtKB/Swiss-Prot Summary: MEIG1_HUMAN, Q5JSS6Function: Essential for spermiogenesis (By similarity)Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for MEIG1 | |  | Search LifeMap BioReagents cell lines for MEIG1 | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEIG1 |
Pathways & Interactions
for MEIG1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MEIG1
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for MEIG1 (Q5JSS63 ENSP000003674864) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007283 | spermatogenesis |
IEA | -- | | GO:0030154 | cell differentiation |
IEA | -- |
MEIG1 for ontologies About GeneDecksing
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Drugs & Compounds
for MEIG1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for MEIG1
Search CenterWatch for drugs/clinical trials and news about MEIG1
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Transcripts
for MEIG1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Sirion Biotech,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for MEIG1 gene: NM_001080836.2 Unigene Cluster for MEIG1: Meiosis expressed gene 1 homolog (mouse) Hs.257249 [show with all ESTs]Unigene Representative Sequence: NM_0010808365 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000477770 ENST00000496225 ENST00000378240 ENST00000467536 ENST00000407572(uc009xjk.1)
Primer
Products: |  | OriGene qSTAR qPCR primer pairs in human, mouse for MEIG1
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MEIG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEIG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEIG1 |
3 DOTS entries: DT.70104294 DT.92418680 DT.305470
GeneLoc Exon Structure
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Expression
for MEIG1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MEIG1 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGAATTGGTA
About this image
See MEIG1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MEIG1
SOURCE GeneReport for Unigene cluster: Hs.257249
SABiosciences Custom PCR Arrays for MEIG1
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for MEIG1
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MEIG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEIG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEIG1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEIG1 |
Orthologs
for MEIG1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for MEIG1 gene from 3/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MEIG16 |
meiosis expressed gene 1 homolog (mouse) |
71(a) |
1 ↔ 1 |
1(7339036-7344816) |
lizard
(Anolis carolinensis) |
Reptilia |
MEIG16 |
meiosis expressed gene 1 homolog (mouse) |
48(a) |
1 ↔ 1 |
GL343559.1(297523-304536) |
zebrafish
(Danio rerio) |
Actinopterygii |
meig16 |
meiosis expressed gene 1 homolog |
68(a) |
1 ↔ 1 |
4(8672141-8674111) |
Species with no ortholog for MEIG1
ENSEMBL Gene Tree for MEIG1 (if available)
TreeFam Gene Tree for MEIG1 (if available) |
Paralogs
for MEIG1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MEIG1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MEIG1 (15001438 - 15030049 bp)
Structural Variations
Database of Genomic Variants (DGV) 10/14 variations for MEIG1 (see all 14): About this table
| | SABiosciences Cancer Mutation PCR Assays |
| | SeqTarget long-range PCR primers for resequencing MEIG1 |
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Disorders
/ Diseases
for MEIG1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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OMIM gene information: 614174
OMIM disorders: --
2  diseases for MEIG1: About MalaCardsomenn syndrome premature ovarian failure
1 disease from the University of Copenhagen DISEASES database for MEIG1:Omenn syndrome
MEIG1 for disorders About GeneDecksing
Export disorders for MEIG1 gene to outside databases
|
Publications
for MEIG1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MEIG1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MEIG1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Germ cell-specific disruption of the Meig1 gene causes impaired spermiogenesis in mice. (PubMed id 23258628)1, 3 Teves M.E....Zhang Z. (2013)
- MEIG1 is essential for spermiogenesis in mice. (PubMed id 19805151)1 Zhang Z....Strauss J.F. (2009)
- Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1 Jeronimo C.... Coulombe B. (2007)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
- Haploinsufficiency for the murine orthologue of Chlam ydomonas PF20 disrupts spermatogenesis. (PubMed id 15328412)1 Zhang Z....Strauss J.F. (2004)
- Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)1 Harrington J.J.... Ducar M. (2001)
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External Searches for MEIG1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MEIG1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing MEIG1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MEIG1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for MEIG1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MEIG1 gene:
Search GeneIP for patents involving MEIG1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MEIG1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MEIG1 | | | QIAGEN SeqTarget long-range PCR primers for resequencing MEIG1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEIG1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEIG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEIG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEIG1 |
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 |  |  |  | |
| | | | Search Tocris compounds for MEIG1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEIG1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for MEIG1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MEIG1 |
| |  |  |  | | | | LSBio Antibodies in human, mouse, rat for MEIG1 |
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