Aliases for MEIG1 Gene
Aliases for MEIG1 Gene
External Ids for MEIG1 Gene
- HGNC: 23429
- Entrez Gene: 644890
- Ensembl: ENSG00000197889
- OMIM: 614174
- UniProtKB: Q5JSS6
Previous GeneCards Identifiers for MEIG1 Gene
- GC10U900466
- GC10P015042
- GC10P014911
- GC10P015001
Summaries for MEIG1 Gene
GeneCards Summary for MEIG1 Gene
MEIG1 (Meiosis/Spermiogenesis Associated 1) is a Protein Coding gene. Diseases associated with MEIG1 include Omenn Syndrome.
UniProtKB/Swiss-Prot for MEIG1 Gene
-
Essential for spermiogenesis.
No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEIG1 Gene
Genomics for MEIG1 Gene
Regulatory Elements for MEIG1 Gene
Enhancers for MEIG1 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around MEIG1 on UCSC Golden Path with GeneCards custom track
Promoters for MEIG1 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around MEIG1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the MEIG1 gene promoter:
Regulatory Element Products
Genomic Location for MEIG1 Gene
- Chromosome:
- 10
- Start:
- 14,954,228 bp from pter
- End:
- 14,988,050 bp from pter
- Size:
- 33,823 bases
- Orientation:
- Plus strand
Genomic View for MEIG1 Gene
Genes around MEIG1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p13 by Ensembl
- 10p13 by Entrez Gene
- 10p13 by HGNC
MEIG1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MEIG1 Gene
Proteins for MEIG1 Gene
-
Protein details for MEIG1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5JSS6-MEIG1_HUMAN
- Recommended name:
- Meiosis expressed gene 1 protein homolog
- Protein Accession:
- Q5JSS6
Protein attributes for MEIG1 Gene
- Size:
- 88 amino acids
- Molecular mass:
- 10795 Da
- Quaternary structure:
-
- Interacts with PACRG.
Post-translational modifications for MEIG1 Gene
Other Protein References for MEIG1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MEIG1
- Novus Biologicals Antibodies for MEIG1
- Invitrogen Antibodies for MEIG1
- antibodies-online Antibodies for MEIG1: See all 27
- GeneTex MEIG1 antibody for MEIG1
-
Custom Antibody ServicesProSci Antibodies for MEIG1
Protein Products
-
OriGene Purified Proteins for MEIG1
- Search Origene for MassSpec and Protein Over-expression Lysates for MEIG1
- Origene Custom Protein Services for MEIG1
- antibodies-online Proteins for MEIG1: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for MEIG1
Assay Products
No data available for DME Specific Peptides for MEIG1 Gene
Domains & Families for MEIG1 Gene
Protein Domains for MEIG1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MEIG1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q5JSS6- Family:
-
- Belongs to the MEIG1 family.
No data available for Gene Families for MEIG1 Gene
Function for MEIG1 Gene
Molecular function for MEIG1 Gene
- UniProtKB/Swiss-Prot Function:
- Essential for spermiogenesis.
Phenotypes for MEIG1 Gene
- MGI mutant phenotypes for MEIG1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for MEIG1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for MEIG1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MEIG1 gene
- Search ViGene Biosciences for MEIG1
CRISPR Products
-
OriGene CRISPR knockouts for MEIG1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MEIG1
- GenScript: Design CRISPR guide RNA sequences for MEIG1
miRNA for MEIG1 Gene
- miRTarBase miRNAs that target MEIG1
miRNA Products
- Search ViGene Biosciences for MEIG1
Clone Products
- OriGene clones in human for MEIG1
- OriGene ORF clones in human,mouse,rat for MEIG1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for MEIG1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MEIG1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MEIG1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEIG1 Gene
Localization for MEIG1 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 2 |
| cytoskeleton | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MEIG1 Gene
Pathways & Interactions for MEIG1 Gene
More details on SuperPathways for MEIG1
No Data Available
Interacting Proteins for MEIG1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007283 | spermatogenesis | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for MEIG1 Gene
Transcripts for MEIG1 Gene
mRNA/cDNA for MEIG1 Gene
- (2) REFSEQ mRNAs :
- (0) Additional mRNA sequences :
-
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MEIG1 Gene
- Meiosis expressed gene 1 homolog (mouse):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MEIG1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MEIG1
- GenScript: Design CRISPR guide RNA sequences for MEIG1
miRNA Products
- Search ViGene Biosciences for MEIG1
Clone Products
- OriGene clones in human for MEIG1
- OriGene ORF clones in human,mouse,rat for MEIG1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
Flow Cytometry Products
Expression for MEIG1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Mature Sertoli Cells Seminiferous Tubules
- Germ Cells (Reproductive System)
- Gonad
-
Lung (Respiratory System)
-
Heart (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for MEIG1 Gene
This gene is overexpressed in Testis (x16.9).
SOURCE GeneReport for Unigene cluster for MEIG1 Gene Hs.257249
Primer Products
-
OriGene qPCR primer pairs for MEIG1
No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MEIG1 Gene
Orthologs for MEIG1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | MEIG1 35 |
|
||
| MEIG1 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | MEIG1 35 |
|
||
| MEIG1 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Meig1 35 |
|
||
| Meig1 16 |
|
||||
| Meig1 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | MEIG1 35 |
|
||
| -- 36 |
|
OneToMany | |||
| -- 36 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Meig1 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MEIG1 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MEIG1 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MEIG1 35 |
|
||
| MEIG1 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | MEIG1 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | meig1 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | meig1 35 |
|
||
| meig1 36 |
|
OneToOne | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToOne |
- Species with no ortholog for MEIG1:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MEIG1 Gene
No data available for Paralogs for MEIG1 Gene
Variants for MEIG1 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs4750568 | - | 14,966,494(+) | ACCAA(A/C)ATCAG | reference, missense | |
| rs1574040 | -- | 14,971,622(+) | TTGAG(C/T)TGCTT | intron-variant | |
| rs1574041 | -- | 14,971,782(+) | TACTT(G/T)GAATG | intron-variant | |
| rs1935399 | -- | 14,972,441(-) | TCAAA(C/T)AGTTA | intron-variant | |
| rs1935400 | -- | 14,972,419(-) | TTACA(C/G)AAACA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv469720 | CNV | Complex | 16826518 |
| nsv831793 | CNV | Loss | 17160897 |
| dgv68n27 | CNV | Gain | 19166990 |
| nsv894891 | CNV | Gain+Loss | 21882294 |
| dgv69n27 | CNV | Gain | 19166990 |
| esv2733506 | CNV | Deletion | 23290073 |
| nsv435909 | CNV | Deletion | 17901297 |
| nsv825256 | CNV | Gain | 20364138 |
| dgv616n71 | CNV | Gain | 21882294 |
| nsv466753 | CNV | Loss | 19166990 |
| nsv470922 | CNV | Gain | 18288195 |
| nsv520429 | CNV | Gain+Loss | 19592680 |
| nsv24586 | CNV | Loss | 16902084 |
| nsv894894 | CNV | Loss | 21882294 |
Residual Variation Intolerance Score:
75.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.96;
19.75% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MEIG1 Gene
Disorders for MEIG1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| omenn syndrome |
|
|
Search MEIG1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for MEIG1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- MEIG1
No data available for UniProtKB/Swiss-Prot and Genatlas for MEIG1 Gene
Publications for MEIG1 Gene
- Germ cell-specific disruption of the Meig1 gene causes impaired spermiogenesis in mice. (PMID: 23258628) Teves M.E. … Zhang Z. (Andrology 2013) 2 3 67
- MEIG1 is essential for spermiogenesis in mice. (PMID: 19805151) Zhang Z. … Strauss J.F. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3
- Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PMID: 17643375) Jeronimo C. … Coulombe B. (Mol. Cell 2007) 3
- Haploinsufficiency for the murine orthologue of Chlamydomonas PF20 disrupts spermatogenesis. (PMID: 15328412) Zhang Z. … Strauss J.F. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
- Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington J.J. … Ducar M. (Nat. Biotechnol. 2001) 3
Products for MEIG1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for MEIG1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MEIG1
- Search Origene for MassSpec and Protein Over-expression Lysates for MEIG1
- Origene Custom Protein Services for MEIG1
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for MEIG1
- Browse OriGene Inhibitory RNA Products For MEIG1
- OriGene qPCR primer pairs for MEIG1
- OriGene CRISPR knockouts for MEIG1
- OriGene clones in human for MEIG1
- OriGene ORF clones in human,mouse,rat for MEIG1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for MEIG1
- GenScript Custom Assay Services for MEIG1
- GenScript Custom overexpressing Cell Line Services for MEIG1
- GenScript: Design CRISPR guide RNA sequences for MEIG1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MEIG1
- Novus Biologicals Antibodies for MEIG1
- Novus Biologicals proteins and lysates for MEIG1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Invitrogen Antibodies for MEIG1
- antibodies-online Antibodies for MEIG1: See all 27
- Search antibodies-online for kits
- antibodies-online Proteins for MEIG1: See all 5
- Search antibodies-online for peptides
- GeneTex MEIG1 antibody for MEIG1
- Search GeneTex for Proteins for MEIG1
- ViGene Biosciences adenoviral particle packaged cDNA for MEIG1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MEIG1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MEIG1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MEIG1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MEIG1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MEIG1 gene
- Search ViGene Biosciences for MEIG1
- Search ViGene Biosciences for MEIG1
- Custom Antibody ServicesProSci Antibodies for MEIG1
Sources for MEIG1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon