Free for academic non-profit institutions. Other users need a Commercial license

MEIG1 Gene(Protein Coding)

Meiosis/Spermiogenesis Associated 1

GCID:
GC10P014954
GIFtS:
42
Genes Participants
UDN Logo

Aliases for MEIG1 Gene

Aliases for MEIG1 Gene

  • Meiosis/Spermiogenesis Associated 1 2 3 5
  • Spermatogenesis Associated 39 2 3
  • Meiosis Expressed Gene 1 Homolog (Mouse) 2
  • Meiosis Expressed Gene 1 Protein Homolog 3
  • Meiosis Expressed Gene 1 Homolog 3
  • BA2K17.3 3
  • SPATA39 3

External Ids for MEIG1 Gene

Previous GeneCards Identifiers for MEIG1 Gene

  • GC10U900466
  • GC10P015042
  • GC10P014911
  • GC10P015001

Summaries for MEIG1 Gene

GeneCards Summary for MEIG1 Gene

MEIG1 (Meiosis/Spermiogenesis Associated 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MEIG1 Gene

  • Essential for spermiogenesis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEIG1 Gene

Genomics for MEIG1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for MEIG1 Gene

Enhancers for MEIG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G015207 1.2 FANTOM5 Ensembl ENCODE 12.5 +254.3 254271 1.9 IRF2 CBFB ZNF10 ZBTB40 CBX5 CREB1 ETV6 IRF1 MLLT1 MEIG1 NMT2 CDNF OLAH C10orf111 LOC105376433 LOC105376434
GH10G015149 0.7 FANTOM5 1.3 +195.0 194981 0.3 HIC1 YY2 SUZ12 ZNF580 CREB1 YBX1 NR2C2 NMT2 C10orf111 MEIG1 PPIAP30 GC10P015124
GH10G014950 1.1 ENCODE 0.7 -1.3 -1290 4.9 HDGF PKNOX1 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 MINDY3 MEIG1 GC10P014933
GH10G014939 0.7 ENCODE 0.4 -15.0 -15032 0.2 PKNOX1 BHLHE40 NR2F1 ELF4 ELF1 DPF2 ZNF592 FOSL1 ATF3 IKZF1 GC10P014933 MEIG1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MEIG1 on UCSC Golden Path with GeneCards custom track

Promoters for MEIG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000024882 -328 1801 HDGF PKNOX1 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Transcription factor binding sites by QIAGEN in the MEIG1 gene promoter:

Genomic Location for MEIG1 Gene

Chromosome:
10
Start:
14,954,228 bp from pter
End:
14,988,050 bp from pter
Size:
33,823 bases
Orientation:
Plus strand

Genomic View for MEIG1 Gene

Genes around MEIG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEIG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEIG1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MEIG1 Gene

Proteins for MEIG1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MEIG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JSS6-MEIG1_HUMAN
    Recommended name:
    Meiosis expressed gene 1 protein homolog
    Protein Accession:
    Q5JSS6

    Protein attributes for MEIG1 Gene

    Size:
    88 amino acids
    Molecular mass:
    10795 Da
    Quaternary structure:
    • Interacts with PACRG.

neXtProt entry for MEIG1 Gene

Post-translational modifications for MEIG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MEIG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MEIG1 Gene

Domains & Families for MEIG1 Gene

Protein Domains for MEIG1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MEIG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JSS6

UniProtKB/Swiss-Prot:

MEIG1_HUMAN :
  • Belongs to the MEIG1 family.
Family:
  • Belongs to the MEIG1 family.
genes like me logo Genes that share domains with MEIG1: view

No data available for Gene Families for MEIG1 Gene

Function for MEIG1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for MEIG1 Gene

UniProtKB/Swiss-Prot Function:
Essential for spermiogenesis.
genes like me logo Genes that share phenotypes with MEIG1: view

Animal Models for MEIG1 Gene

MGI Knock Outs for MEIG1:

Animal Model Products

CRISPR Products

miRNA for MEIG1 Gene

miRTarBase miRNAs that target MEIG1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEIG1 Gene

Localization for MEIG1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEIG1 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for MEIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with MEIG1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MEIG1 Gene

Pathways & Interactions for MEIG1 Gene

SuperPathways for MEIG1 Gene

PathCards logo More details on SuperPathways for MEIG1
No Data Available

Gene Ontology (GO) - Biological Process for MEIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with MEIG1: view

No data available for Pathways by source and SIGNOR curated interactions for MEIG1 Gene

Drugs & Compounds for MEIG1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MEIG1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MEIG1 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MEIG1 Gene

Meiosis expressed gene 1 homolog (mouse):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEIG1 Gene

No ASD Table

Relevant External Links for MEIG1 Gene

GeneLoc Exon Structure for
MEIG1
ECgene alternative splicing isoforms for
MEIG1

Expression for MEIG1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEIG1 Gene

mRNA expression in normal human tissues for MEIG1 Gene
mRNA expression by GTEx for MEIG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEIG1 Gene

This gene is overexpressed in Testis (x16.9).

NURSA nuclear receptor signaling pathways regulating expression of MEIG1 Gene:

MEIG1

SOURCE GeneReport for Unigene cluster for MEIG1 Gene:

Hs.257249
genes like me logo Genes that share expression patterns with MEIG1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEIG1 Gene

Orthologs for MEIG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MEIG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia -- 35
  • 98 (a)
 OneToMany
MEIG1 34
  • 97.73 (n)
-- 35
  • 95 (a)
 OneToMany
cow
(Bos Taurus)
 Mammalia MEIG1 34 35
  • 94.32 (n)
dog
(Canis familiaris)
 Mammalia MEIG1 34 35
  • 93.94 (n)
oppossum
(Monodelphis domestica)
 Mammalia MEIG1 35
  • 92 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Meig1 34
  • 88.64 (n)
mouse
(Mus musculus)
 Mammalia Meig1 34 16 35
  • 87.12 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia MEIG1 35
  • 86 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves MEIG1 34 35
  • 79.31 (n)
lizard
(Anolis carolinensis)
 Reptilia MEIG1 35
  • 48 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia meig1 34
  • 77.27 (n)
zebrafish
(Danio rerio)
 Actinopterygii meig1 34 35
  • 68.58 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 58 (a)
 OneToOne
Species where no ortholog for MEIG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEIG1 Gene

ENSEMBL:
Gene Tree for MEIG1 (if available)
TreeFam:
Gene Tree for MEIG1 (if available)

Paralogs for MEIG1 Gene

No data available for Paralogs for MEIG1 Gene

Variants for MEIG1 Gene

Sequence variations from dbSNP and Humsavar for MEIG1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000008995 -- 14,973,097(+) CTGAC(A/C)TCAAG intron-variant
rs1000187447 -- 14,962,542(+) TTATG(C/T)ATAGT intron-variant
rs1000299782 -- 14,967,969(+) ACTTG(A/C)ATTGG intron-variant
rs1000579147 -- 14,960,877(+) CAAAA(A/T)AATTA intron-variant
rs1000617560 -- 14,963,175(+) CACTG(A/C)AACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEIG1 Gene

Variant ID Type Subtype PubMed ID
dgv178e212 CNV gain 25503493
dgv678n100 CNV gain 25217958
dgv68n27 CNV gain 19166990
dgv69n27 CNV gain 19166990
dgv961n54 CNV gain 21841781
dgv962n54 CNV gain 21841781
dgv963n54 CNV loss 21841781
dgv964n54 CNV gain 21841781
esv2733506 CNV deletion 23290073
esv2760142 CNV gain 21179565
esv3622433 CNV loss 21293372
esv3622434 CNV gain 21293372
esv3891763 CNV gain 25118596
nsv1037136 CNV gain+loss 25217958
nsv1038491 CNV gain 25217958
nsv1045188 CNV loss 25217958
nsv24586 CNV deletion 16902084
nsv435909 CNV deletion 17901297
nsv466753 CNV loss 19166990
nsv469720 CNV gain 16826518
nsv470922 CNV gain 18288195
nsv520429 CNV gain+loss 19592680
nsv550007 CNV gain+loss 21841781
nsv825256 CNV gain 20364138
nsv831793 CNV loss 17160897

Variation tolerance for MEIG1 Gene

Residual Variation Intolerance Score: 75.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEIG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEIG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEIG1 Gene

Disorders for MEIG1 Gene

Relevant External Links for MEIG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEIG1

No disorders were found for MEIG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEIG1 Gene

Publications for MEIG1 Gene

  1. Germ cell-specific disruption of the Meig1 gene causes impaired spermiogenesis in mice. (PMID: 23258628) Teves M.E. … Zhang Z. (Andrology 2013) 2 3 64
  2. MEIG1 is essential for spermiogenesis in mice. (PMID: 19805151) Zhang Z. … Strauss J.F. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 64
  3. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PMID: 17643375) Jeronimo C. … Coulombe B. (Mol. Cell 2007) 3 64
  4. Haploinsufficiency for the murine orthologue of Chlamydomonas PF20 disrupts spermatogenesis. (PMID: 15328412) Zhang Z. … Strauss J.F. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 64
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 4 64

Products for MEIG1 Gene

Sources for MEIG1 Gene

Content
Loading form....