Aliases for MEIG1 Gene
Aliases for MEIG1 Gene
External Ids for MEIG1 Gene
- HGNC: 23429
- Entrez Gene: 644890
- Ensembl: ENSG00000197889
- OMIM: 614174
- UniProtKB: Q5JSS6
Previous GeneCards Identifiers for MEIG1 Gene
- GC10U900466
- GC10P015042
- GC10P014911
- GC10P015001
Summaries for MEIG1 Gene
GeneCards Summary for MEIG1 Gene
MEIG1 (Meiosis/Spermiogenesis Associated 1) is a Protein Coding gene.
UniProtKB/Swiss-Prot for MEIG1 Gene
-
Essential for spermiogenesis.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEIG1 Gene
Genomics for MEIG1 Gene
GeneHancer (GH) Regulatory Elements for MEIG1 Gene
Promoters and enhancers for MEIG1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MEIG1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MEIG1 Gene
Genomic Locations for MEIG1 Gene
- chr10:14,954,228-14,988,050
- (GRCh38/hg38)
- Size:
- 33,823 bases
- Orientation:
- Plus strand
- chr10:15,001,438-15,030,049
- (GRCh37/hg19)
Genomic View for MEIG1 Gene
Genes around MEIG1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p13 by Ensembl
- 10p13 by Entrez Gene
- 10p13 by HGNC
MEIG1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)


RefSeq DNA sequence for MEIG1 Gene
Proteins for MEIG1 Gene
-
Protein details for MEIG1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5JSS6-MEIG1_HUMAN
- Recommended name:
- Meiosis expressed gene 1 protein homolog
- Protein Accession:
- Q5JSS6
Protein attributes for MEIG1 Gene
- Size:
- 88 amino acids
- Molecular mass:
- 10795 Da
- Quaternary structure:
-
- Interacts with PACRG.
Post-translational modifications for MEIG1 Gene
No Post-translational modifications
Other Protein References for MEIG1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
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Protein Products
-
OriGene Purified Proteins for MEIG1
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- antibodies-online: Search results for 6 available MEIG1 Proteins ranked by validation data
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-
Quality Products:
- Search GeneTex for Proteins for MEIG1
Assay Products
No data available for DME Specific Peptides for MEIG1 Gene
Domains & Families for MEIG1 Gene
Gene Families for MEIG1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for MEIG1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MEIG1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q5JSS6- Family:
-
- Belongs to the MEIG1 family.
Function for MEIG1 Gene
Molecular function for MEIG1 Gene
- UniProtKB/Swiss-Prot Function:
- Essential for spermiogenesis.
Phenotypes for MEIG1 Gene
- MGI mutant phenotypes for MEIG1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for MEIG1:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for MEIG1 gene
-
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CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for MEIG1 Gene
- miRTarBase miRNAs that target MEIG1
miRNA Products
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Inhibitory RNA Products
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-
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Clone Products
- VectorBuilder custom plasmid, inducible vectors for MEIG1
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available MEIG1 gene related products
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- Applied Biological Materials Clones for MEIG1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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Horizon Cell Lines for MEIG1
-
ViGene Biosciences adenoviral particle packaged cDNA for MEIG1 gene
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEIG1 Gene
Localization for MEIG1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MEIG1 Gene
Pathways & Interactions for MEIG1 Gene
No Data Available
Interacting Proteins for MEIG1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007283 | spermatogenesis | IEA | -- |
GO:0030154 | cell differentiation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for MEIG1 Gene
Transcripts for MEIG1 Gene
mRNA/cDNA for MEIG1 Gene
- (1) REFSEQ mRNAs :
- (0) Additional mRNA sequences :
- -
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MEIG1 Gene
- Meiosis expressed gene 1 homolog (mouse):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MEIG1
- genomics-online: gRNA clones - Search results for available MEIG1 gene related products
- Applied Biological Materials CRISPR for MEIG1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MEIG1
- GenScript: Design CRISPR guide RNA sequences for MEIG1
miRNA Products
- Search ViGene Biosciences for MEIG1
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for MEIG1
- Browse OriGene Inhibitory RNA Products For MEIG1
- genomics-online: shRNA clones - Search results for available MEIG1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MEIG1 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for MEIG1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MEIG1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available MEIG1 gene related products
- orf clones - Search results for available MEIG1 gene related products
- Applied Biological Materials Clones for MEIG1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MEIG1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Mature Sertoli Cells Seminiferous Tubules
- Germ Cells (Reproductive System)
- Gonad
-
Lung (Respiratory System)
-
Heart (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for MEIG1 Gene
This gene is overexpressed in Testis (x16.9).
NURSA nuclear receptor signaling pathways regulating expression of MEIG1 Gene:
MEIG1SOURCE GeneReport for Unigene cluster for MEIG1 Gene:
Hs.257249Primer Products
-
OriGene qPCR primer pairs for MEIG1
- genomics-online: primer clones - Search results for available MEIG1 gene related products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEIG1 Gene
Orthologs for MEIG1 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | -- 34 |
|
OneToMany | |
MEIG1 33 |
|
||||
-- 34 |
|
OneToMany | |||
cow (Bos Taurus) |
Mammalia | MEIG1 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | MEIG1 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | MEIG1 34 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Meig1 33 |
|
||
mouse (Mus musculus) |
Mammalia | Meig1 33 16 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | MEIG1 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | MEIG1 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | MEIG1 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | meig1 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | meig1 33 34 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for MEIG1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MEIG1 Gene
No data available for Paralogs for MEIG1 Gene
Variants for MEIG1 Gene
SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000008995 | -- | 14,973,097(+) | C/A | downstream_transcript_variant | |
rs1000187447 | -- | 14,962,542(+) | T/C | intron_variant | |
rs1000299782 | -- | 14,967,969(+) | C/A | intron_variant | |
rs1000579147 | -- | 14,960,877(+) | A/T | intron_variant | |
rs1000617560 | -- | 14,963,175(+) | C/A | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv178e212 | CNV | gain | 25503493 |
dgv678n100 | CNV | gain | 25217958 |
dgv68n27 | CNV | gain | 19166990 |
dgv69n27 | CNV | gain | 19166990 |
dgv961n54 | CNV | gain | 21841781 |
dgv962n54 | CNV | gain | 21841781 |
dgv963n54 | CNV | loss | 21841781 |
dgv964n54 | CNV | gain | 21841781 |
esv2733506 | CNV | deletion | 23290073 |
esv2760142 | CNV | gain | 21179565 |
esv3622433 | CNV | loss | 21293372 |
esv3622434 | CNV | gain | 21293372 |
esv3891763 | CNV | gain | 25118596 |
nsv1037136 | CNV | gain+loss | 25217958 |
nsv1038491 | CNV | gain | 25217958 |
nsv1045188 | CNV | loss | 25217958 |
nsv24586 | CNV | deletion | 16902084 |
nsv435909 | CNV | deletion | 17901297 |
nsv466753 | CNV | loss | 19166990 |
nsv469720 | CNV | gain | 16826518 |
nsv470922 | CNV | gain | 18288195 |
nsv520429 | CNV | gain+loss | 19592680 |
nsv550007 | CNV | gain+loss | 21841781 |
nsv825256 | CNV | gain | 20364138 |
nsv831793 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
75.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.96;
19.75% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MEIG1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MEIG1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEIG1 Gene
Disorders for MEIG1 Gene
Additional Disease Information for MEIG1
No disorders were found for MEIG1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEIG1 Gene
Publications for MEIG1 Gene
- Germ cell-specific disruption of the Meig1 gene causes impaired spermiogenesis in mice. (PMID: 23258628) Teves ME … Zhang Z (Andrology 2013) 2 3 58
- MEIG1 is essential for spermiogenesis in mice. (PMID: 19805151) Zhang Z … Strauss JF (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 58
- Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PMID: 17643375) Jeronimo C … Coulombe B (Molecular cell 2007) 3 58
- The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4 58
- Haploinsufficiency for the murine orthologue of Chlamydomonas PF20 disrupts spermatogenesis. (PMID: 15328412) Zhang Z … Strauss JF (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 58
Products for MEIG1 Gene
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- Invitrogen Antibodies for MEIG1
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 27 available MEIG1 Antibodies ranked by validation data
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- antibodies-online: Search results for available MEIG1 related products ranked by validation data
- antibodies-online: Search results for 6 available MEIG1 Proteins ranked by validation data
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Sources for MEIG1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
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- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
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- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
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- (119) Disease Ontology
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- (133) ENCODE
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- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew