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MEIG1 Gene

protein-coding   GIFtS: 41
GCID: GC10P015001

Meiosis/Spermiogenesis Associated 1

(Previous name: meiosis expressed gene 1 homolog (mouse))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Meiosis/Spermiogenesis Associated 11 2     bA2K17.32
Spermatogenesis Associated 391 2     Meiosis Expressed Gene 1 Homolog2
Meiosis Expressed Gene 1 Homolog (Mouse)1     Meiosis Expressed Gene 1 Protein Homolog2
SPATA392     

External Ids:    HGNC: 234291   Entrez Gene: 6448902   Ensembl: ENSG000001978897   OMIM: 6141745   UniProtKB: Q5JSS63   
ORGUL members:         

Export aliases for MEIG1 gene to outside databases

Previous GC identifers: GC10U900466 GC10P015042 GC10P014911


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MEIG1 Gene:
MEIG1 (meiosis/spermiogenesis associated 1) is a protein-coding gene. Diseases associated with MEIG1 include omenn syndrome, and premature ovarian failure.

UniProtKB/Swiss-Prot: MEIG1_HUMAN, Q5JSS6
Function: Essential for spermiogenesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MEIG1 gene promoter:
         p53   Egr-1   Tal-1beta   ITF-2   Evi-1   FOXL1   YY1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MEIG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEIG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p13   Ensembl cytogenetic band:  10p13   HGNC cytogenetic band: 10p13

MEIG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEIG1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P015001:  view genomic region     (about GC identifiers)

Start:
15,001,438 bp from pter      End:
15,030,049 bp from pter
Size:
28,612 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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UniProtKB/Swiss-Prot: MEIG1_HUMAN, Q5JSS6 (See protein sequence)
Recommended Name: Meiosis expressed gene 1 protein homolog  
Size: 88 amino acids; 10795 Da
Subunit: Interacts with PACRG (By similarity)

Explore the universe of human proteins at neXtProt for MEIG1: NX_Q5JSS6

Explore proteomics data for MEIG1 at MOPED


See MEIG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001074305.1  
ENSEMBL proteins: 
 ENSP00000367486   ENSP00000384334  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR020186 Meiosis-expressed_gene_1

Graphical View of Domain Structure for InterPro Entry Q5JSS6

ProtoNet protein and cluster: Q5JSS6

UniProtKB/Swiss-Prot: MEIG1_HUMAN, Q5JSS6
Similarity: Belongs to the MEIG1 family


MEIG1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: MEIG1_HUMAN, Q5JSS6
Function: Essential for spermiogenesis (By similarity)

Animal Models:

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
nucleus2

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

MEIG1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MEIG1
Interactions:

    Search GeneGlobe Interaction Network for MEIG1

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for MEIG1 (Q5JSS63 ENSP000003674864) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
POLR2JP524353, ENSP000002926144I2D: score=1 STRING: ENSP00000292614
SPAG16Q8N0X23, ENSP000003325924I2D: score=1 STRING: ENSP00000332592
ENSG00000230475ENSP000004054284STRING: ENSP00000405428
PACRGENSP000003379464STRING: ENSP00000337946
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007283spermatogenesis IEA--
GO:0030154cell differentiation IEA--

MEIG1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for MEIG1



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MEIG1 gene: 
NM_001080836.2  

Unigene Cluster for MEIG1:

Meiosis expressed gene 1 homolog (mouse)
Hs.257249  [show with all ESTs]
Unigene Representative Sequence: NM_001080836
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000477770 ENST00000496225 ENST00000378240 ENST00000467536 ENST00000407572(uc009xjk.1)

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3 DOTS entries:

DT.70104294  DT.305470  DT.92418680 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MEIG1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGAATTGGTA
MEIG1 Expression
About this image

MEIG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MEIG1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.257249
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MEIG1 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Meig11 meiosis expressed gene 1 87.12(n)
87.5(a)
  104362  NM_008579.4  NP_032605.1 
chicken
(Gallus gallus)
Aves MEIG11 meiosis expressed gene 1 homolog (mouse) 79.31(n)
77.01(a)
  769589  XM_001231712.3  XP_001231713.1 
lizard
(Anolis carolinensis)
Reptilia MEIG16
meiosis/spermiogenesis associated 1
48(a)
1 ↔ 1
GL343559.1(297523-304536)
tropical clawed frog
(Xenopus tropicalis)
Amphibia meig11 meiosis/spermiogenesis associated 1 77.27(n)
79.55(a)
  549276  NM_001016522.2  NP_001016522.1 
zebrafish
(Danio rerio)
Actinopterygii meig11 meiosis expressed gene 1 homolog 68.58(n)
71.26(a)
  541343  NM_001013470.1  NP_001013488.1 


ENSEMBL Gene Tree for MEIG1 (if available)
TreeFam Gene Tree for MEIG1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MEIG1 (see all 417)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1397988871,2
C--14999487(+) GATCCA/GGGGCT 1 -- us2k10--------
rs1922724311,2
--14999488(+) ATCCGA/GGGCTA 1 -- us2k10--------
rs1420702201,2
C--14999490(+) CCGGGA/GCTACA 1 -- us2k10--------
rs1162128581,2
F--14999496(+) CTACAG/AAGGAA 1 -- us2k11Minor allele frequency- A:0.01WA 118
rs1827281471,2
--14999656(+) TGAGAC/TGGAGT 1 -- us2k10--------
rs1879001691,2
--14999669(+) CCCTCC/TATGCC 1 -- us2k10--------
rs1911008771,2
--14999704(+) CTCGGC/TTCACT 1 -- us2k10--------
rs1826072771,2
--14999726(+) CTCCAC/TCTCCA 1 -- us2k10--------
rs1132187921,2
C,F--14999748(+) CAAGCA/G/TATTCT 1 -- us2k11CSA 2
rs1868858131,2
--14999763(+) CCTCAC/GCCTCC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for MEIG1 (15001438 - 15030049 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for MEIG1 (see all 14):    About this table    
Variant IDTypeSubtypePubMed ID
nsv435909CNV Deletion17901297
esv2733506CNV Deletion23290073
nsv831793CNV Loss17160897
nsv466753CNV Loss19166990
nsv894894CNV Loss21882294
nsv24586CNV Loss16902084
dgv69n27CNV Gain19166990
nsv470922CNV Gain18288195
nsv825256CNV Gain20364138
dgv68n27CNV Gain19166990

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 614174    OMIM disorders: --

2 diseases for MEIG1:    
About MalaCards
omenn syndrome    premature ovarian failure

1 disease from the University of Copenhagen DISEASES database for MEIG1:
Omenn syndrome

MEIG1 for disorders           About GeneDecksing


Export disorders for MEIG1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MEIG1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with MEIG1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Germ cell-specific disruption of the Meig1 gene causes impaired spermiogenesis in mice. (PubMed id 23258628)1, 3 Teves M.E....Zhang Z. (Andrology 2013)
  2. MEIG1 is essential for spermiogenesis in mice. (PubMed id 19805151)1 Zhang Z....Strauss J.F. (Proc. Natl. Acad. Sci. U.S.A. 2009)
  3. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1 Jeronimo C.... Coulombe B. (Mol. Cell 2007)
  4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (Nature 2004)
  5. Haploinsufficiency for the murine orthologue of Chlamydomonas PF20 disrupts spermatogenesis. (PubMed id 15328412)1 Zhang Z....Strauss J.F. (Proc. Natl. Acad. Sci. U.S.A. 2004)
  6. Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)1 Harrington J.J.... Ducar M. (Nat. Biotechnol. 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 644890 HGNC: 23429 Ensembl:ENSG00000197889 euGenes: HUgn644890 ECgene: MEIG1
H-InvDB: MEIG1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MEIG1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MEIG1 gene:
Search GeneIP for patents involving MEIG1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Browse SwitchGear 3'UTR luciferase reporter plasmids for MEIG1
 Browse SwitchGear Promoter luciferase reporter plasmids for MEIG1
 Search ThermoFisher Antibodies for MEIG1
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MEIG1
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MEIG1
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MEIG1
 LSBio Antibodies in human, mouse, rat for MEIG1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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