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Aliases for MEIG1 Gene

Aliases for MEIG1 Gene

  • Meiosis/Spermiogenesis Associated 1 2 3
  • Spermatogenesis Associated 39 2 3
  • Meiosis Expressed Gene 1 Homolog (Mouse) 2
  • Meiosis Expressed Gene 1 Homolog 3
  • BA2K17.3 3
  • SPATA39 3

External Ids for MEIG1 Gene

Previous GeneCards Identifiers for MEIG1 Gene

  • GC10U900466
  • GC10P015042
  • GC10P014911
  • GC10P015001

Summaries for MEIG1 Gene

GeneCards Summary for MEIG1 Gene

MEIG1 (Meiosis/Spermiogenesis Associated 1) is a Protein Coding gene. Diseases associated with MEIG1 include omenn syndrome.

UniProtKB/Swiss-Prot for MEIG1 Gene

  • Essential for spermiogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEIG1 Gene

Genomics for MEIG1 Gene

Regulatory Elements for MEIG1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MEIG1 Gene

14,954,228 bp from pter
14,988,050 bp from pter
33,823 bases
Plus strand

Genomic View for MEIG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEIG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEIG1 Gene

Proteins for MEIG1 Gene

  • Protein details for MEIG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Meiosis expressed gene 1 protein homolog
    Protein Accession:

    Protein attributes for MEIG1 Gene

    88 amino acids
    Molecular mass:
    10795 Da
    Quaternary structure:
    • Interacts with PACRG.

neXtProt entry for MEIG1 Gene

Proteomics data for MEIG1 Gene at MOPED

Post-translational modifications for MEIG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MEIG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEIG1 Gene

Domains & Families for MEIG1 Gene

Protein Domains for MEIG1 Gene


Suggested Antigen Peptide Sequences for MEIG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MEIG1 family.
  • Belongs to the MEIG1 family.
genes like me logo Genes that share domains with MEIG1: view

No data available for Gene Families for MEIG1 Gene

Function for MEIG1 Gene

Molecular function for MEIG1 Gene

UniProtKB/Swiss-Prot Function:
Essential for spermiogenesis.

Phenotypes for MEIG1 Gene

GenomeRNAi human phenotypes for MEIG1:
genes like me logo Genes that share phenotypes with MEIG1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MEIG1 Gene

Localization for MEIG1 Gene

Subcellular locations from

Jensen Localization Image for MEIG1 Gene COMPARTMENTS Subcellular localization image for MEIG1 gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for MEIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with MEIG1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MEIG1 Gene

Pathways & Interactions for MEIG1 Gene

SuperPathways for MEIG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with MEIG1: view

No data available for Pathways by source and SIGNOR curated interactions for MEIG1 Gene

Drugs & Compounds for MEIG1 Gene

No Compound Related Data Available

Transcripts for MEIG1 Gene

mRNA/cDNA for MEIG1 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MEIG1 Gene

Meiosis expressed gene 1 homolog (mouse):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEIG1 Gene

No ASD Table

Relevant External Links for MEIG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MEIG1 Gene

mRNA expression in normal human tissues for MEIG1 Gene

mRNA differential expression in normal tissues according to GTEx for MEIG1 Gene

This gene is overexpressed in Testis (x16.9).

SOURCE GeneReport for Unigene cluster for MEIG1 Gene Hs.257249

genes like me logo Genes that share expression patterns with MEIG1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MEIG1 Gene

Orthologs for MEIG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MEIG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MEIG1 35
  • 94.32 (n)
  • 94.32 (a)
MEIG1 36
  • 94 (a)
(Canis familiaris)
Mammalia MEIG1 35
  • 93.94 (n)
  • 95.45 (a)
MEIG1 36
  • 95 (a)
(Mus musculus)
Mammalia Meig1 35
  • 87.12 (n)
  • 87.5 (a)
Meig1 36
  • 88 (a)
(Pan troglodytes)
Mammalia MEIG1 35
  • 97.73 (n)
  • 95.45 (a)
-- 36
  • 95 (a)
-- 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Meig1 35
  • 88.64 (n)
  • 92.05 (a)
(Monodelphis domestica)
Mammalia MEIG1 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia MEIG1 36
  • 86 (a)
(Gallus gallus)
Aves MEIG1 35
  • 79.31 (n)
  • 77.01 (a)
MEIG1 36
  • 71 (a)
(Anolis carolinensis)
Reptilia MEIG1 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia meig1 35
  • 77.27 (n)
  • 79.55 (a)
(Danio rerio)
Actinopterygii meig1 35
  • 68.58 (n)
  • 71.26 (a)
meig1 36
  • 68 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
Species with no ortholog for MEIG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEIG1 Gene

Gene Tree for MEIG1 (if available)
Gene Tree for MEIG1 (if available)

Paralogs for MEIG1 Gene

No data available for Paralogs for MEIG1 Gene

Variants for MEIG1 Gene

Sequence variations from dbSNP and Humsavar for MEIG1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1574040 -- 14,971,622(+) TTGAG(C/T)TGCTT intron-variant
rs1574041 -- 14,971,782(+) TACTT(G/T)GAATG intron-variant
rs1935399 -- 14,972,441(-) TCAAA(C/T)AGTTA intron-variant
rs1935400 -- 14,972,419(-) TTACA(C/G)AAACA intron-variant
rs1935401 -- 14,972,370(-) AGTAT(G/T)ATACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEIG1 Gene

Variant ID Type Subtype PubMed ID
nsv469720 CNV Complex 16826518
nsv831793 CNV Loss 17160897
dgv68n27 CNV Gain 19166990
nsv894891 CNV Gain+Loss 21882294
dgv69n27 CNV Gain 19166990
esv2733506 CNV Deletion 23290073
nsv435909 CNV Deletion 17901297
nsv825256 CNV Gain 20364138
dgv616n71 CNV Gain 21882294
nsv466753 CNV Loss 19166990
nsv470922 CNV Gain 18288195
nsv520429 CNV Gain+Loss 19592680
nsv24586 CNV Loss 16902084
nsv894894 CNV Loss 21882294

Variation tolerance for MEIG1 Gene

Residual Variation Intolerance Score: 75.18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEIG1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEIG1 Gene

Disorders for MEIG1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MEIG1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
omenn syndrome
  • reticuloendotheliosis familial with eosinophilia
- elite association
Search MEIG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MEIG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MEIG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEIG1 Gene

Publications for MEIG1 Gene

  1. Germ cell-specific disruption of the Meig1 gene causes impaired spermiogenesis in mice. (PMID: 23258628) Teves M.E. … Zhang Z. (Andrology 2013) 2 67
  2. MEIG1 is essential for spermiogenesis in mice. (PMID: 19805151) Zhang Z. … Strauss J.F. (Proc. Natl. Acad. Sci. U.S.A. 2009) 67
  3. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PMID: 17643375) Jeronimo C. … Coulombe B. (Mol. Cell 2007) 67
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 67
  5. Haploinsufficiency for the murine orthologue of Chlamydomonas PF20 disrupts spermatogenesis. (PMID: 15328412) Zhang Z. … Strauss J.F. (Proc. Natl. Acad. Sci. U.S.A. 2004) 67

Products for MEIG1 Gene

Sources for MEIG1 Gene

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