MEIG1 Gene

Aliases
for MEIG1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC10U900466 GC10P015042 GC10P014911

Summaries
for MEIG1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for MEIG1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000010.10  NT_008705.17  NC_018921.2  

Browse SwitchGear Promoter luciferase reporter plasmids

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEIG1

MEIG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P015001:  view genomic region     (about GC identifiers)

Proteins
for MEIG1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for MEIG1: NX_Q5JSS6

Explore proteomics data for MEIG1 at MOPED


See MEIG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

MEIG1 Human Recombinant Protein Products:

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	antibodies-online proteins for MEIG1 (3 products)
	antibodies-online peptides for MEIG1

MEIG1 Antibody Products:

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MEIG1 Assay Products:

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	antibodies-online kits for MEIG1 (5 products)

Domains /
Families
for MEIG1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q5JSS6

Find genes that share domains with MEIG1           About GenesLikeMe

Function
for MEIG1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for MEIG1

miRNA Products:		Block miRNA regulation of human, mouse, rat MEIG1 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate MEIG1
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MEIG1
		Predesigned siRNA for gene silencing in human, mouse, rat MEIG1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for MEIG1

Clone Products:		OriGene clones in human, mouse for MEIG1 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MEIG1 (NM_001080836)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEIG1
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MEIG1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MEIG1
		Browse ESI BIO Cell Lines and PureStem Progenitors for MEIG1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEIG1

Localization
for MEIG1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytosol	2
nucleus	2

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for MEIG1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 2 biological process terms:    About this table

Drugs & Compounds
for MEIG1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for MEIG1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for MEIG1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MEIG1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGAATTGGTA

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for MEIG1
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MEIG1
		QuantiTect SYBR Green Assays in human, mouse, rat MEIG1
		QuantiFast Probe-based Assays in human, mouse, rat MEIG1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEIG1

Orthologs
for MEIG1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for MEIG1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Genomic Variants
for MEIG1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MEIG1 (see all 417)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1397988871,2	C	--	14999487(+)	GATCCA/GGGGCT	1	--	us2k1		0	--	--	--	--
rs1922724311,2		--	14999488(+)	ATCCGA/GGGCTA	1	--	us2k1		0	--	--	--	--
rs1420702201,2	C	--	14999490(+)	CCGGGA/GCTACA	1	--	us2k1		0	--	--	--	--
rs1162128581,2	F	--	14999496(+)	CTACAG/AAGGAA	1	--	us2k1		1		WA	118
rs1827281471,2		--	14999656(+)	TGAGAC/TGGAGT	1	--	us2k1		0	--	--	--	--
rs1879001691,2		--	14999669(+)	CCCTCC/TATGCC	1	--	us2k1		0	--	--	--	--
rs1911008771,2		--	14999704(+)	CTCGGC/TTCACT	1	--	us2k1		0	--	--	--	--
rs1826072771,2		--	14999726(+)	CTCCAC/TCTCCA	1	--	us2k1		0	--	--	--	--
rs1132187921,2	C,F	--	14999748(+)	CAAGCA/G/TATTCT	1	--	us2k1		1		CSA	2
rs1868858131,2		--	14999763(+)	CCTCAC/GCCTCC	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for MEIG1 (15001438 - 15030049 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for MEIG1 (see all 14):    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv435909	CNV	Deletion	17901297
esv2733506	CNV	Deletion	23290073
nsv831793	CNV	Loss	17160897
nsv466753	CNV	Loss	19166990
nsv894894	CNV	Loss	21882294
nsv24586	CNV	Loss	16902084
dgv69n27	CNV	Gain	19166990
nsv470922	CNV	Gain	18288195
nsv825256	CNV	Gain	20364138
dgv68n27	CNV	Gain	19166990

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing MEIG1

DNA2.0 Custom Variant and Variant Library Synthesis for MEIG1

Disorders / Diseases
for MEIG1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for MEIG1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Germ cell-specific disruption of the Meig1 gene causes impaired spermiogenesis in mice. (PubMed id 23258628)^{1, 3} Teves M.E....Zhang Z. (Andrology 2013)
2. MEIG1 is essential for spermiogenesis in mice. (PubMed id 19805151)¹ Zhang Z....Strauss J.F. (Proc. Natl. Acad. Sci. U.S.A. 2009)
3. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)¹ Jeronimo C.... Coulombe B. (Mol. Cell 2007)
4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)² Deloukas P.... Rogers J. (Nature 2004)
5. Haploinsufficiency for the murine orthologue of Chlamydomonas PF20 disrupts spermatogenesis. (PubMed id 15328412)¹ Zhang Z....Strauss J.F. (Proc. Natl. Acad. Sci. U.S.A. 2004)
6. Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)¹ Harrington J.J.... Ducar M. (Nat. Biotechnol. 2001)

External Searches for MEIG1 gene

Genome Databases showing MEIG1 gene

Other Databases showing MEIG1 gene

Specialized Databases showing MEIG1 gene

Products
for MEIG1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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