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Aliases for MEI4 Gene

Aliases for MEI4 Gene

  • Meiotic Double-Stranded Break Formation Protein 4 2 3 5
  • Meiosis-Specific 4 Homolog (S. Cerevisiae) 2

External Ids for MEI4 Gene

Previous GeneCards Identifiers for MEI4 Gene

  • GC00U934167
  • GC06U902472
  • GC06P078401

Summaries for MEI4 Gene

GeneCards Summary for MEI4 Gene

MEI4 (Meiotic Double-Stranded Break Formation Protein 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MEI4 Gene

  • Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis.

Additional gene information for MEI4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEI4 Gene

Genomics for MEI4 Gene

Regulatory Elements for MEI4 Gene

Enhancers for MEI4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H078597 0.9 Ensembl ENCODE 4.7 +949.0 948970 2 JUN CEBPB RAD21 EP300 RFX5 JUND POLR2A STAT3 RCOR1 FOS MEI4 IRAK1BP1 GC06M078505 ENSG00000230309
GH06H077649 0.9 Ensembl ENCODE 0.7 +0.1 96 1 CTCF L3MBTL2 NRF1 BHLHE40 MAX REST MNT BRCA1 RAD21 YY1 MEI4 GC06P077658
GH06H077502 0.2 ENCODE 0.1 -147.0 -147048 0 HTR1B ENSG00000219253 MEI4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MEI4 on UCSC Golden Path with GeneCards custom track

Genomic Location for MEI4 Gene

Chromosome:
6
Start:
77,650,233 bp from pter
End:
77,927,045 bp from pter
Size:
276,813 bases
Orientation:
Plus strand

Genomic View for MEI4 Gene

Genes around MEI4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEI4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEI4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEI4 Gene

Proteins for MEI4 Gene

  • Protein details for MEI4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MW99-MEI4_HUMAN
    Recommended name:
    Meiosis-specific protein MEI4
    Protein Accession:
    A8MW99
    Secondary Accessions:
    • R4GMV8

    Protein attributes for MEI4 Gene

    Size:
    385 amino acids
    Molecular mass:
    44024 Da
    Quaternary structure:
    • Interacts with REC114. Part of the MCD recombinosome complex, at least composed of IHO1/CCDC36, REC114 and MEI4.

neXtProt entry for MEI4 Gene

Post-translational modifications for MEI4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MEI4 Gene

No data available for DME Specific Peptides for MEI4 Gene

Domains & Families for MEI4 Gene

Gene Families for MEI4 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for MEI4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

A8MW99

UniProtKB/Swiss-Prot:

MEI4_HUMAN :
  • Belongs to the MEI4L family.
Family:
  • Belongs to the MEI4L family.
genes like me logo Genes that share domains with MEI4: view

No data available for Suggested Antigen Peptide Sequences for MEI4 Gene

Function for MEI4 Gene

Molecular function for MEI4 Gene

UniProtKB/Swiss-Prot Function:
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis.

Phenotypes From GWAS Catalog for MEI4 Gene

genes like me logo Genes that share phenotypes with MEI4: view

Animal Models for MEI4 Gene

MGI Knock Outs for MEI4:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MEI4 Gene

Localization for MEI4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEI4 Gene

Chromosome. Note=Specifically localizes to unsynapsed chromosomal regions during meiosis. Located in discrete foci on the axes of meiotic chromosomes. The number of foci is highest at leptonema, decreases at zygonema and is strongly reduced in pachynema and subsequent stages. {ECO:0000250 UniProtKB:Q8BRM6}.

Gene Ontology (GO) - Cellular Components for MEI4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000800 lateral element ISS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with MEI4: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MEI4 Gene

Pathways & Interactions for MEI4 Gene

No Data Available

Interacting Proteins for MEI4 Gene

Selected Interacting proteins: A8MW99-MEI4_HUMAN for MEI4 Gene via IID

Symbol External ID(s) Details
REC114

Gene Ontology (GO) - Biological Process for MEI4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006310 DNA recombination IEA --
GO:0007129 synapsis IEA,ISS --
GO:0007283 spermatogenesis ISS,IEA --
GO:0042138 meiotic DNA double-strand break formation ISS --
GO:0048477 oogenesis IEA,ISS --
genes like me logo Genes that share ontologies with MEI4: view

No data available for Pathways by source and SIGNOR curated interactions for MEI4 Gene

Drugs & Compounds for MEI4 Gene

No Compound Related Data Available

Transcripts for MEI4 Gene

mRNA/cDNA for MEI4 Gene

(4) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MEI4 Gene

No ASD Table

Relevant External Links for MEI4 Gene

GeneLoc Exon Structure for
MEI4
ECgene alternative splicing isoforms for
MEI4

Expression for MEI4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEI4 Gene

mRNA differential expression in normal tissues according to GTEx for MEI4 Gene

This gene is overexpressed in Testis (x8.8), Pancreas (x4.8), Kidney - Cortex (x4.7), and Pituitary (x4.5).

Protein differential expression in normal tissues from HIPED for MEI4 Gene

This gene is overexpressed in Lavage (50.9) and Fetal gut (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MEI4 Gene



Protein tissue co-expression partners for MEI4 Gene

NURSA nuclear receptor signaling pathways regulating expression of MEI4 Gene:

MEI4
genes like me logo Genes that share expression patterns with MEI4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEI4 Gene

Orthologs for MEI4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MEI4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MEI4 33 34
  • 87.15 (n)
cow
(Bos Taurus)
Mammalia LOC101902979 33
  • 83.07 (n)
mouse
(Mus musculus)
Mammalia Mei4 33 16 34
  • 78.85 (n)
rat
(Rattus norvegicus)
Mammalia Mei4 33
  • 76.22 (n)
oppossum
(Monodelphis domestica)
Mammalia MEI4 34
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEI4 34
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101748468 33
  • 64.62 (n)
lizard
(Anolis carolinensis)
Reptilia MEI4 34
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496694 33
  • 54.84 (n)
zebrafish
(Danio rerio)
Actinopterygii mei4 33 34
  • 45.25 (n)
Species where no ortholog for MEI4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEI4 Gene

ENSEMBL:
Gene Tree for MEI4 (if available)
TreeFam:
Gene Tree for MEI4 (if available)

Paralogs for MEI4 Gene

No data available for Paralogs for MEI4 Gene

Variants for MEI4 Gene

Sequence variations from dbSNP and Humsavar for MEI4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000003301 -- 77,706,218(+) TGTAA(C/G)AGCTG intron-variant
rs1000015377 -- 77,803,820(+) CCGAT(C/T)GTTCC intron-variant
rs1000041937 -- 77,805,809(+) AACAG(-/A)AAAAT intron-variant
rs1000079841 -- 77,822,135(+) ATTAC(A/G)TTAAA intron-variant
rs1000086450 -- 77,838,212(+) AACCA(A/T)CTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEI4 Gene

Variant ID Type Subtype PubMed ID
esv2264169 CNV deletion 18987734
esv2459772 CNV deletion 19546169
esv2617806 CNV deletion 19546169
esv2665464 CNV deletion 23128226
esv2669872 CNV deletion 23128226
esv2759446 CNV gain 17122850
esv3305091 CNV mobile element insertion 20981092
esv3308261 CNV mobile element insertion 20981092
esv33879 CNV gain 17666407
esv3413303 CNV insertion 20981092
esv3609640 CNV loss 21293372
esv3609641 CNV loss 21293372
esv3609642 CNV loss 21293372
esv3609643 CNV loss 21293372
esv3609644 CNV loss 21293372
nsv1020922 CNV loss 25217958
nsv1031368 CNV loss 25217958
nsv499600 CNV loss 21111241
nsv508414 CNV deletion 20534489
nsv510921 OTHER complex 20534489
nsv511901 CNV loss 21212237
nsv517110 CNV loss 19592680
nsv5361 CNV deletion 18451855
nsv603812 CNV gain 21841781
nsv830702 CNV loss 17160897

Variation tolerance for MEI4 Gene

Gene Damage Index Score: 4.70; 66.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEI4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEI4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEI4 Gene

Disorders for MEI4 Gene

Relevant External Links for MEI4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEI4

No disorders were found for MEI4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEI4 Gene

Publications for MEI4 Gene

  1. Initiation of meiotic recombination in mammals. (PMID: 24710101) Kumar R … De Massy B (Genes 2010) 2 3 60
  2. Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. (PMID: 20551173) Kumar R … de Massy B (Genes & development 2010) 2 3 60
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60

Products for MEI4 Gene

Sources for MEI4 Gene

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