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Aliases for MEI4 Gene

Aliases for MEI4 Gene

  • Meiotic Double-Stranded Break Formation Protein 4 2 3 5
  • Meiosis-Specific 4 Homolog (S. Cerevisiae) 2

External Ids for MEI4 Gene

Previous GeneCards Identifiers for MEI4 Gene

  • GC00U934167
  • GC06U902472
  • GC06P078401

Summaries for MEI4 Gene

GeneCards Summary for MEI4 Gene

MEI4 (Meiotic Double-Stranded Break Formation Protein 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MEI4 Gene

  • Required for meiotic DNA double-strand break formation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEI4 Gene

Genomics for MEI4 Gene

Regulatory Elements for MEI4 Gene

Enhancers for MEI4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MEI4 on UCSC Golden Path with GeneCards custom track

Genomic Location for MEI4 Gene

77,650,233 bp from pter
77,927,045 bp from pter
276,813 bases
Plus strand

Genomic View for MEI4 Gene

Genes around MEI4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEI4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEI4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEI4 Gene

Proteins for MEI4 Gene

  • Protein details for MEI4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Meiosis-specific protein MEI4-like
    Protein Accession:
    Secondary Accessions:
    • R4GMV8

    Protein attributes for MEI4 Gene

    385 amino acids
    Molecular mass:
    44024 Da
    Quaternary structure:
    • Interacts with REC114.

neXtProt entry for MEI4 Gene

Proteomics data for MEI4 Gene at MOPED

Post-translational modifications for MEI4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MEI4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEI4 Gene

Domains & Families for MEI4 Gene

Protein Domains for MEI4 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MEI4L family.
  • Belongs to the MEI4L family.
genes like me logo Genes that share domains with MEI4: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MEI4 Gene

Function for MEI4 Gene

Molecular function for MEI4 Gene

UniProtKB/Swiss-Prot Function:
Required for meiotic DNA double-strand break formation.
genes like me logo Genes that share phenotypes with MEI4: view

Animal Models for MEI4 Gene

MGI Knock Outs for MEI4:

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MEI4 Gene

Localization for MEI4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEI4 Gene

Chromosome. Note=Located in discrete foci on the axes of meiotic chromosomes. The number of foci is highest at leptonema, decreases at zygonema and is strongly reduced in pachynema and subsequent stages (By similarity). {ECO:0000250}.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MEI4 Gene

Pathways & Interactions for MEI4 Gene

SuperPathways for MEI4 Gene

No Data Available

Interacting Proteins for MEI4 Gene

Gene Ontology (GO) - Biological Process for MEI4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006310 DNA recombination IEA --
GO:0007129 synapsis IEA,ISS --
GO:0007283 spermatogenesis IEA,ISS --
GO:0042138 meiotic DNA double-strand break formation IEA,ISS --
genes like me logo Genes that share ontologies with MEI4: view

No data available for Pathways by source and SIGNOR curated interactions for MEI4 Gene

Drugs & Compounds for MEI4 Gene

No Compound Related Data Available

Transcripts for MEI4 Gene

mRNA/cDNA for MEI4 Gene

(5) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MEI4 Gene

No ASD Table

Relevant External Links for MEI4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MEI4 Gene

mRNA expression in normal human tissues for MEI4 Gene

mRNA differential expression in normal tissues according to GTEx for MEI4 Gene

This gene is overexpressed in Testis (x8.8), Pancreas (x4.8), Kidney - Cortex (x4.7), and Pituitary (x4.5).

Protein differential expression in normal tissues from HIPED for MEI4 Gene

This gene is overexpressed in Lavage (50.9) and Fetal gut (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MEI4 Gene

genes like me logo Genes that share expression patterns with MEI4: view

Protein tissue co-expression partners for MEI4 Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MEI4 Gene

Orthologs for MEI4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MEI4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC101902979 35
  • 83.07 (n)
  • 74.08 (a)
(Canis familiaris)
Mammalia MEI4 35
  • 87.15 (n)
  • 77.66 (a)
MEI4 36
  • 76 (a)
(Mus musculus)
Mammalia Mei4 35
  • 78.85 (n)
  • 72.06 (a)
Mei4 16
Mei4 36
  • 71 (a)
(Rattus norvegicus)
Mammalia Mei4 35
  • 76.22 (n)
  • 70.05 (a)
(Monodelphis domestica)
Mammalia MEI4 36
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia MEI4 36
  • 33 (a)
(Gallus gallus)
Aves LOC101748468 35
  • 64.62 (n)
  • 50.27 (a)
(Anolis carolinensis)
Reptilia MEI4 36
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496694 35
  • 54.84 (n)
  • 39.11 (a)
(Danio rerio)
Actinopterygii mei4 35
  • 45.25 (n)
  • 33.63 (a)
mei4 36
  • 28 (a)
Species with no ortholog for MEI4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEI4 Gene

Gene Tree for MEI4 (if available)
Gene Tree for MEI4 (if available)

Paralogs for MEI4 Gene

No data available for Paralogs for MEI4 Gene

Variants for MEI4 Gene

Sequence variations from dbSNP and Humsavar for MEI4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1033142 -- 77,881,725(+) ATTTT(C/G)AGCTG intron-variant
rs1033143 -- 77,881,968(+) TGCAG(A/G)TTACA intron-variant
rs1116882 -- 77,772,852(+) taaat(G/T)tgtgg intron-variant
rs1156760 -- 77,846,469(-) AGCAG(A/G)GCAAA intron-variant
rs1157630 -- 77,741,607(+) ATTCT(A/G)TGTGT intron-variant

Variation tolerance for MEI4 Gene

Gene Damage Index Score: 4.70; 66.08% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MEI4 Gene

Disorders for MEI4 Gene

Relevant External Links for MEI4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MEI4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEI4 Gene

Publications for MEI4 Gene

  1. Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. (PMID: 20551173) Kumar R. … de Massy B. (Genes Dev. 2010) 2 3 67
  2. Initiation of meiotic recombination in mammals. (PMID: 24710101) Kumar R. … De Massy B. (Genes (Basel) 2010) 2 3
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3

Products for MEI4 Gene

Sources for MEI4 Gene