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Aliases for MEI1 Gene

Aliases for MEI1 Gene

  • Meiotic Double-Stranded Break Formation Protein 1 2 3 5
  • Spermatogenesis Associated 38 2 3
  • Meiosis Defective Protein 1 3 4
  • Meiosis Inhibitor 1 2 3
  • Meiosis Defective 1 3
  • SPATA38 3

External Ids for MEI1 Gene

Previous GeneCards Identifiers for MEI1 Gene

  • GC22P040426
  • GC22P042095
  • GC22P025060

Summaries for MEI1 Gene

GeneCards Summary for MEI1 Gene

MEI1 (Meiotic Double-Stranded Break Formation Protein 1) is a Protein Coding gene. Diseases associated with MEI1 include azoospermia. GO annotations related to this gene include binding.

UniProtKB/Swiss-Prot for MEI1 Gene

  • Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEI1 Gene

Genomics for MEI1 Gene

Regulatory Elements for MEI1 Gene

Promoters for MEI1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MEI1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MEI1 Gene

Chromosome:
22
Start:
41,699,499 bp from pter
End:
41,799,456 bp from pter
Size:
99,958 bases
Orientation:
Plus strand

Genomic View for MEI1 Gene

Genes around MEI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEI1 Gene

Proteins for MEI1 Gene

  • Protein details for MEI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TIA1-MEI1_HUMAN
    Recommended name:
    Meiosis inhibitor protein 1
    Protein Accession:
    Q5TIA1
    Secondary Accessions:
    • B7Z745
    • Q1XAP1
    • Q1XAP2
    • Q8IYJ5
    • Q8N5K5
    • Q8N9H3
    • Q8TC68

    Protein attributes for MEI1 Gene

    Size:
    1274 amino acids
    Molecular mass:
    141161 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH25400.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH35720.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MEI1 Gene

neXtProt entry for MEI1 Gene

Proteomics data for MEI1 Gene at MOPED

Post-translational modifications for MEI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MEI1 Gene

No data available for DME Specific Peptides for MEI1 Gene

Domains & Families for MEI1 Gene

Protein Domains for MEI1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MEI1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MEI1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MEI1 Gene

Function for MEI1 Gene

Molecular function for MEI1 Gene

UniProtKB/Swiss-Prot Function:
Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity).

Phenotypes for MEI1 Gene

genes like me logo Genes that share phenotypes with MEI1: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MEI1 Gene

Localization for MEI1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEI1 Gene COMPARTMENTS Subcellular localization image for MEI1 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
cytosol 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MEI1 Gene

Pathways & Interactions for MEI1 Gene

SuperPathways for MEI1 Gene

No Data Available

Interacting Proteins for MEI1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000384115%0d%0a9606.ENSP00000250495%0d%0a
Selected Interacting proteins: ENSP00000384115 for MEI1 Gene via STRING

Symbol External ID(s) Details
NEDD8

Gene Ontology (GO) - Biological Process for MEI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007127 meiosis I IBA --
GO:0007141 male meiosis I IEA --
GO:0007276 gamete generation IEA --
GO:0007286 spermatid development IEA --
genes like me logo Genes that share ontologies with MEI1: view

No data available for Pathways by source and SIGNOR curated interactions for MEI1 Gene

Drugs & Compounds for MEI1 Gene

No Compound Related Data Available

Transcripts for MEI1 Gene

mRNA/cDNA for MEI1 Gene

(23) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MEI1 Gene

Meiosis inhibitor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEI1 Gene

No ASD Table

Relevant External Links for MEI1 Gene

GeneLoc Exon Structure for
MEI1
ECgene alternative splicing isoforms for
MEI1

Expression for MEI1 Gene

mRNA expression in normal human tissues for MEI1 Gene

mRNA differential expression in normal tissues according to GTEx for MEI1 Gene

This gene is overexpressed in Testis (x14.5), Whole Blood (x7.5), and Spleen (x5.0).

Protein differential expression in normal tissues from HIPED for MEI1 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MEI1 Gene



SOURCE GeneReport for Unigene cluster for MEI1 Gene Hs.116419

mRNA Expression by UniProt/SwissProt for MEI1 Gene

Q5TIA1-MEI1_HUMAN
Tissue specificity: Expressed predominantly in testis. Weakly expressed in spleen and thymus.
genes like me logo Genes that share expression patterns with MEI1: view

Protein tissue co-expression partners for MEI1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MEI1 Gene

Orthologs for MEI1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MEI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEI1 35
  • 99.42 (n)
  • 99.06 (a)
MEI1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MEI1 36
  • 82 (a)
OneToOne
MEI1 35
  • 86.19 (n)
  • 82.78 (a)
dog
(Canis familiaris)
Mammalia MEI1 35
  • 88.1 (n)
  • 86.87 (a)
MEI1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mei1 36
  • 77 (a)
OneToOne
Mei1 35
  • 83.04 (n)
  • 80.62 (a)
Mei1 16
oppossum
(Monodelphis domestica)
Mammalia MEI1 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEI1 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mei1 35
  • 83.73 (n)
  • 81.08 (a)
chicken
(Gallus gallus)
Aves MEI1 35
  • 62.81 (n)
  • 55.42 (a)
MEI1 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mei1 35
  • 56.32 (n)
  • 52.18 (a)
zebrafish
(Danio rerio)
Actinopterygii MEI1 36
  • 35 (a)
OneToOne
Species with no ortholog for MEI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEI1 Gene

ENSEMBL:
Gene Tree for MEI1 (if available)
TreeFam:
Gene Tree for MEI1 (if available)

Paralogs for MEI1 Gene

No data available for Paralogs for MEI1 Gene

Variants for MEI1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MEI1 Gene

Q5TIA1-MEI1_HUMAN
Genetic variation in MEI1 may predispose European American but not Israeli men to azoospermia by meiotic arrest.

Sequence variations from dbSNP and Humsavar for MEI1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs17002655 - 41,758,382(+) TGTCT(C/G)AGCTC nc-transcript-variant, reference, missense
rs17002665 - 41,776,114(+) TCTAT(A/T)CCAGC nc-transcript-variant, reference, missense
rs12484839 - 41,784,396(+) TTCCA(A/G)AGAAA intron-variant, nc-transcript-variant, reference, missense
rs126092 -- 41,782,437(+) AAGAG(A/G)AGAGC intron-variant
rs139540 -- 41,782,036(+) TGTTT(C/T)ATATT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MEI1 Gene

Variant ID Type Subtype PubMed ID
nsv524585 CNV Loss 19592680
nsv834209 CNV Loss 17160897
nsv915155 CNV Loss 21882294
esv273219 CNV Insertion 20981092
esv2451668 CNV Deletion 19546169
esv2724269 CNV Deletion 23290073
dgv110n6 CNV Loss 16902084
esv2134270 CNV Deletion 18987734
esv3963 CNV Deletion 18987735
esv2439659 CNV Deletion 19546169
esv1676083 CNV Deletion 17803354
esv8122 CNV Loss 19470904
nsv3640 CNV Insertion 18451855

Variation tolerance for MEI1 Gene

Residual Variation Intolerance Score: 11.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.01; 80.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEI1 Gene

HapMap Linkage Disequilibrium report
MEI1

Disorders for MEI1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MEI1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
azoospermia
  • spermatogenic failure
- elite association - COSMIC cancer census association via MalaCards
Search MEI1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MEI1

Genetic Association Database (GAD)
MEI1
Human Genome Epidemiology (HuGE) Navigator
MEI1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEI1
genes like me logo Genes that share disorders with MEI1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEI1 Gene

Publications for MEI1 Gene

  1. Polymorphic alleles of the human MEI1 gene are associated with human azoospermia by meiotic arrest. (PMID: 16683055) Sato H. … Sengoku K. (J. Hum. Genet. 2006) 2 3 4 67
  2. Initiation of meiotic recombination in mammals. (PMID: 24710101) Kumar R. … De Massy B. (Genes (Basel) 2010) 2 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Analysis of Nedd8-associated polypeptides: a model for deciphering the pathway for ubiquitin-like modifications. (PMID: 16503656) Norman J.A. … Shiekhattar R. (Biochemistry 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for MEI1 Gene

Sources for MEI1 Gene

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