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Aliases for MEI1 Gene

Aliases for MEI1 Gene

  • Meiosis Inhibitor 1 2 3
  • Spermatogenesis Associated 38 2 3
  • Meiosis Defective Protein 1 3 4
  • Meiosis Inhibitor Protein 1 3
  • Meiosis Defective 1 3
  • SPATA38 3

External Ids for MEI1 Gene

Previous GeneCards Identifiers for MEI1 Gene

  • GC22P040426
  • GC22P042095
  • GC22P025060

Summaries for MEI1 Gene

GeneCards Summary for MEI1 Gene

MEI1 (Meiosis Inhibitor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MEI1 Gene

  • Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEI1 Gene

Genomics for MEI1 Gene

Regulatory Elements for MEI1 Gene

Genomic Location for MEI1 Gene

41,699,499 bp from pter
41,799,456 bp from pter
99,958 bases
Plus strand

Genomic View for MEI1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEI1 Gene

Proteins for MEI1 Gene

  • Protein details for MEI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Meiosis inhibitor protein 1
    Protein Accession:
    Secondary Accessions:
    • B7Z745
    • Q1XAP1
    • Q1XAP2
    • Q8IYJ5
    • Q8N5K5
    • Q8N9H3
    • Q8TC68

    Protein attributes for MEI1 Gene

    1274 amino acids
    Molecular mass:
    141161 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH25400.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH35720.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MEI1 Gene

neXtProt entry for MEI1 Gene

Proteomics data for MEI1 Gene at MOPED

Post-translational modifications for MEI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MEI1 Gene

No data available for DME Specific Peptides for MEI1 Gene

Domains for MEI1 Gene

Protein Domains for MEI1 Gene


Suggested Antigen Peptide Sequences for MEI1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MEI1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MEI1 Gene

Function for MEI1 Gene

Molecular function for MEI1 Gene

UniProtKB/Swiss-Prot Function:
Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity).

Gene Ontology (GO) - Molecular Function for MEI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
genes like me logo Genes that share ontologies with MEI1: view

Phenotypes for MEI1 Gene

genes like me logo Genes that share phenotypes with MEI1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEI1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MEI1 Gene

Localization for MEI1 Gene

Subcellular locations from

Jensen Localization Image for MEI1 Gene COMPARTMENTS Subcellular localization image for MEI1 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
cytosol 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MEI1 Gene

Pathways for MEI1 Gene

SuperPathways for MEI1 Gene

No Data Available

Interacting Proteins for MEI1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000384115 for MEI1 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for MEI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007126 meiotic nuclear division --
GO:0007141 male meiosis I IEA --
GO:0007276 gamete generation --
GO:0007286 spermatid development IEA --
genes like me logo Genes that share ontologies with MEI1: view

No data available for Pathways by source for MEI1 Gene

Transcripts for MEI1 Gene

mRNA/cDNA for MEI1 Gene

Unigene Clusters for MEI1 Gene

Meiosis inhibitor 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEI1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEI1 Gene

No ASD Table

Relevant External Links for MEI1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MEI1 Gene

mRNA expression in normal human tissues for MEI1 Gene

mRNA differential expression in normal tissues according to GTEx for MEI1 Gene

This gene is overexpressed in Testis (14.5), Whole Blood (7.5), and Spleen (5.0).

Protein differential expression in normal tissues for MEI1 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MEI1 Gene

SOURCE GeneReport for Unigene cluster for MEI1 Gene Hs.116419

mRNA Expression by UniProt/SwissProt for MEI1 Gene

Tissue specificity: Expressed predominantly in testis. Weakly expressed in spleen and thymus.
genes like me logo Genes that share expressions with MEI1: view

Expression partners for MEI1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MEI1 Gene

Orthologs for MEI1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MEI1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MEI1 35
  • 86.19 (n)
  • 82.78 (a)
MEI1 36
  • 82 (a)
(Canis familiaris)
Mammalia MEI1 35
  • 88.1 (n)
  • 86.87 (a)
MEI1 36
  • 86 (a)
(Mus musculus)
Mammalia Mei1 35
  • 83.04 (n)
  • 80.62 (a)
Mei1 16
Mei1 36
  • 77 (a)
(Pan troglodytes)
Mammalia MEI1 35
  • 99.42 (n)
  • 99.06 (a)
MEI1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mei1 35
  • 83.73 (n)
  • 81.08 (a)
(Monodelphis domestica)
Mammalia MEI1 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia MEI1 36
  • 54 (a)
(Gallus gallus)
Aves MEI1 35
  • 62.81 (n)
  • 55.42 (a)
MEI1 36
  • 53 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
-- 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mei1 35
  • 56.32 (n)
  • 52.18 (a)
(Danio rerio)
Actinopterygii MEI1 36
  • 35 (a)
Species with no ortholog for MEI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEI1 Gene

Gene Tree for MEI1 (if available)
Gene Tree for MEI1 (if available)

Paralogs for MEI1 Gene

No data available for Paralogs for MEI1 Gene

Variants for MEI1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MEI1 Gene

Genetic variation in MEI1 may predispose European American but not Israeli men to azoospermia by meiotic arrest.

Sequence variations from dbSNP and Humsavar for MEI1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs139540 -- 41,782,036(+) TGTTT(C/T)ATATT intron-variant
rs139541 -- 41,784,685(+) CAGGG(-/G)CCCAG frameshift-variant, reference, intron-variant
rs139542 -- 41,784,888(+) GGATT(-/GAGT)AAGAC intron-variant
rs139546 -- 41,785,896(+) TTTAT(-/T)TTTTT intron-variant
rs139550 -- 41,785,934(+) GAGAC(A/G)GAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEI1 Gene

Variant ID Type Subtype PubMed ID
nsv524585 CNV Loss 19592680
nsv834209 CNV Loss 17160897
nsv915155 CNV Loss 21882294
esv273219 CNV Insertion 20981092
esv2451668 CNV Deletion 19546169
esv2724269 CNV Deletion 23290073
dgv110n6 CNV Loss 16902084
esv2134270 CNV Deletion 18987734
esv3963 CNV Deletion 18987735
esv2439659 CNV Deletion 19546169
esv1676083 CNV Deletion 17803354
esv8122 CNV Loss 19470904
nsv3640 CNV Insertion 18451855

Relevant External Links for MEI1 Gene

HapMap Linkage Disequilibrium report

Disorders for MEI1 Gene

Relevant External Links for MEI1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MEI1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MEI1 Gene

Publications for MEI1 Gene

  1. Polymorphic alleles of the human MEI1 gene are associated with human azoospermia by meiotic arrest. (PMID: 16683055) Sato H. … Sengoku K. (J. Hum. Genet. 2006) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Analysis of Nedd8-associated polypeptides: a model for deciphering the pathway for ubiquitin-like modifications. (PMID: 16503656) Norman J.A. … Shiekhattar R. (Biochemistry 2006) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MEI1 Gene

Sources for MEI1 Gene

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