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Aliases for MEI1 Gene

Aliases for MEI1 Gene

  • Meiotic Double-Stranded Break Formation Protein 1 2 3 5
  • Spermatogenesis Associated 38 2 3
  • Meiosis Defective Protein 1 3 4
  • Meiosis Inhibitor 1 2 3
  • Meiosis Inhibitor Protein 1 3
  • Meiosis Defective 1 3
  • SPATA38 3

External Ids for MEI1 Gene

Previous GeneCards Identifiers for MEI1 Gene

  • GC22P040426
  • GC22P042095
  • GC22P025060

Summaries for MEI1 Gene

GeneCards Summary for MEI1 Gene

MEI1 (Meiotic Double-Stranded Break Formation Protein 1) is a Protein Coding gene. Diseases associated with MEI1 include Aggressive Systemic Mastocytosis. GO annotations related to this gene include binding.

UniProtKB/Swiss-Prot for MEI1 Gene

  • Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity).

Additional gene information for MEI1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEI1 Gene

Genomics for MEI1 Gene

Regulatory Elements for MEI1 Gene

Enhancers for MEI1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H041779 1.1 Ensembl ENCODE 35.1 +81.9 81944 3.6 PKNOX1 ATF1 TBL1XR1 IRF3 MAX ZKSCAN1 RFX5 POLR2A ZNF207 ATF7 MEI1 NDUFA6 ENSG00000184068 SREBF2 RNU6ATAC22P XPNPEP3 CENPM GC22M042246 PIR33994
GH22H041444 1.8 FANTOM5 ENCODE dbSUPER 20.4 -252.8 -252784 5.9 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC L3MBTL2 EP300 ZC3H7B PHF5A SLC25A17 XRCC6 POLR3H NDUFA6-AS1 MEI1 TEF
GH22H041559 1.5 Ensembl ENCODE dbSUPER 23.7 -136.4 -136417 6.9 HDGF PKNOX1 TCF12 ZNF121 GLIS2 FOS REST ZNF662 ZNF592 MEF2D MEI1 POLR3H CSDC2 DESI1 XRCC6 PHF5A SLC25A17 EP300 RANGAP1 CENPM
GH22H041409 2.1 FANTOM5 Ensembl ENCODE dbSUPER 16.8 -286.5 -286524 6.2 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 EP300 ENSG00000272834 MEI1 POLR3H PHF5A CYP2D8P TCF20 XRCC6 SLC25A17 NAGA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MEI1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MEI1 Gene

Genomic Locations for MEI1 Gene
99,958 bases
Plus strand

Genomic View for MEI1 Gene

Genes around MEI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEI1 Gene

Proteins for MEI1 Gene

  • Protein details for MEI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Meiosis inhibitor protein 1
    Protein Accession:
    Secondary Accessions:
    • B7Z745
    • Q1XAP1
    • Q1XAP2
    • Q8IYJ5
    • Q8N5K5
    • Q8N9H3
    • Q8TC68

    Protein attributes for MEI1 Gene

    1274 amino acids
    Molecular mass:
    141161 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH25400.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH35720.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MEI1 Gene

neXtProt entry for MEI1 Gene

Post-translational modifications for MEI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MEI1 Gene

Domains & Families for MEI1 Gene

Gene Families for MEI1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for MEI1 Gene


Suggested Antigen Peptide Sequences for MEI1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MEI1: view

No data available for UniProtKB/Swiss-Prot for MEI1 Gene

Function for MEI1 Gene

Molecular function for MEI1 Gene

UniProtKB/Swiss-Prot Function:
Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity).

Phenotypes From GWAS Catalog for MEI1 Gene

Phenotypes for MEI1 Gene

genes like me logo Genes that share phenotypes with MEI1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MEI1 Gene

Localization for MEI1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEI1 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MEI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with MEI1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MEI1 Gene

Pathways & Interactions for MEI1 Gene

No Data Available

Interacting Proteins for MEI1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000384115 Q5TIA1-MEI1_HUMAN for MEI1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for MEI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007127 meiosis I IBA --
GO:0007141 male meiosis I IEA --
GO:0007276 gamete generation IEA --
GO:0007286 spermatid development IEA --
GO:0045141 meiotic telomere clustering IEA --
genes like me logo Genes that share ontologies with MEI1: view

No data available for Pathways by source and SIGNOR curated interactions for MEI1 Gene

Drugs & Compounds for MEI1 Gene

No Compound Related Data Available

Transcripts for MEI1 Gene

mRNA/cDNA for MEI1 Gene

(23) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MEI1 Gene

Meiosis inhibitor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEI1 Gene

No ASD Table

Relevant External Links for MEI1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MEI1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEI1 Gene

mRNA differential expression in normal tissues according to GTEx for MEI1 Gene

This gene is overexpressed in Testis (x14.5), Whole Blood (x7.5), and Spleen (x5.0).

Protein differential expression in normal tissues from HIPED for MEI1 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MEI1 Gene

Protein tissue co-expression partners for MEI1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MEI1 Gene:


SOURCE GeneReport for Unigene cluster for MEI1 Gene:


mRNA Expression by UniProt/SwissProt for MEI1 Gene:

Tissue specificity: Expressed predominantly in testis. Weakly expressed in spleen and thymus.
genes like me logo Genes that share expression patterns with MEI1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEI1 Gene

Orthologs for MEI1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MEI1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MEI1 33 34
  • 99.42 (n)
(Canis familiaris)
Mammalia MEI1 33 34
  • 88.1 (n)
(Bos Taurus)
Mammalia MEI1 33 34
  • 86.19 (n)
(Rattus norvegicus)
Mammalia Mei1 33
  • 83.73 (n)
(Mus musculus)
Mammalia Mei1 33 16 34
  • 83.04 (n)
(Monodelphis domestica)
Mammalia MEI1 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia MEI1 34
  • 54 (a)
(Gallus gallus)
Aves MEI1 33 34
  • 62.81 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 56 (a)
-- 34
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mei1 33
  • 56.32 (n)
(Danio rerio)
Actinopterygii MEI1 34
  • 35 (a)
Species where no ortholog for MEI1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEI1 Gene

Gene Tree for MEI1 (if available)
Gene Tree for MEI1 (if available)

Paralogs for MEI1 Gene

No data available for Paralogs for MEI1 Gene

Variants for MEI1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MEI1 Gene

Genetic variation in MEI1 may predispose European American but not Israeli men to azoospermia by meiotic arrest.

Sequence variations from dbSNP and Humsavar for MEI1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000037573 -- 41,783,472(+) TTTTT(A/G)GTAGA intron-variant
rs1000044144 -- 41,704,979(+) AAAGT(G/T)CTGGA intron-variant
rs1000057036 -- 41,783,931(+) TCTCA(C/T)CTCAG intron-variant
rs1000108267 -- 41,712,515(+) CAGGC(A/G)TGAGC intron-variant, upstream-variant-2KB
rs1000138613 -- 41,769,682(+) GGCCA(A/G)GCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEI1 Gene

Variant ID Type Subtype PubMed ID
nsv979682 CNV duplication 23825009
nsv955486 CNV deletion 24416366
nsv834209 CNV loss 17160897
nsv524585 CNV loss 19592680
nsv3640 CNV insertion 18451855
nsv1153215 CNV deletion 26484159
nsv1072213 CNV deletion 25765185
nsv1067233 CNV gain 25217958
nsv1062939 CNV gain 25217958
esv8122 CNV loss 19470904
esv3963 CNV loss 18987735
esv3647802 CNV loss 21293372
esv3558182 CNV deletion 23714750
esv3414777 CNV insertion 20981092
esv2724269 CNV deletion 23290073
esv2451668 CNV deletion 19546169
esv2439659 CNV deletion 19546169
esv2134270 CNV deletion 18987734
esv1676083 CNV deletion 17803354
dgv8111n54 CNV gain 21841781
dgv2462n106 CNV deletion 24896259
dgv110n6 CNV deletion 16902084

Variation tolerance for MEI1 Gene

Residual Variation Intolerance Score: 11.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.01; 80.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEI1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for MEI1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MEI1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
aggressive systemic mastocytosis
  • asm
- elite association - COSMIC cancer census association via MalaCards
Search MEI1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MEI1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MEI1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEI1 Gene

Publications for MEI1 Gene

  1. Polymorphic alleles of the human MEI1 gene are associated with human azoospermia by meiotic arrest. (PMID: 16683055) Sato H … Sengoku K (Journal of human genetics 2006) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Initiation of meiotic recombination in mammals. (PMID: 24710101) Kumar R … De Massy B (Genes 2010) 2 3 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. Analysis of Nedd8-associated polypeptides: a model for deciphering the pathway for ubiquitin-like modifications. (PMID: 16503656) Norman JA … Shiekhattar R (Biochemistry 2006) 3 60

Products for MEI1 Gene

Sources for MEI1 Gene

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