MEGF9 Gene
protein-coding GIFtS: 46
GCID: GC09M123363
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multiple EGF-like-domains 9(Previous names: EGF-like-domain, multiple 5 )
(Previous symbol: EGFL5)
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Aliases
for MEGF9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Multiple EGF-Like-Domains 91 2 | | Multiple Epidermal Growth Factor-Like Domains Protein 92 | | EGFL51 2 3 5 | | KIAA08183 | | EGF-Like-Domain, Multiple 51 2 | | EGF-Like Protein 53 | | Epidermal Growth Factor-Like Protein 52 3 | | Multiple EGF-Like Domains Protein 93 |
Export aliases for MEGF9 gene to outside databasesPrevious GC identifers: GC09M122402 GC09M092980 |
Summaries
for MEGF9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for MEGF9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MEGF9 gene promoter:
AhR p300 CBF-C Arnt AREB6 CBF-A CBF-B CP1C CP1A CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for MEGF9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEGF9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q32-q33.3 Ensembl cytogenetic band: 9q33.2 HGNC cytogenetic band: 9q32-q33.3MEGF9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M123363: view genomic region
(about GC identifiers)
Start:
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123,363,091 bp from pter |
End:
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123,476,748 bp from pter |
Size:
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113,658 bases |
Orientation:
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minus strand |
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Proteins
for MEGF9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MEGF9_HUMAN, Q9H1U4 (See
protein sequence)Recommended Name: Multiple epidermal growth factor-like domains protein 9 precursor Size: 602 amino acids; 62984 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Caution: It is uncertain whether Met-1 or Met-9 is the initiator
Sequence caution: Sequence=AAQ88736.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: B7Z315 O75098Explore the universe of human proteins at neXtProt for MEGF9: NX_Q9H1U4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H1U4
MEGF9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001073966.2
ENSEMBL proteins: ENSP00000363040 ENSP00000392666
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0016021 | integral to membrane |
IEA | -- |
MEGF9 for ontologies About GeneDecksing
MEGF9 Antibody Products:
Assay Products for MEGF9: |
Protein
Domains /
Families
for MEGF9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MEGF9 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H1U4ProtoNet protein and cluster: Q9H1U4 1 Blocks protein family: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region
UniProtKB/Swiss-Prot: MEGF9_HUMAN, Q9H1U4Similarity: Contains 5 laminin EGF-like domains |
Function
for MEGF9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEGF9 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEGF9 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MEGF9 (NM_001080497) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MEGF9 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEGF9 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEGF9 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005509 | calcium ion binding |
NAS | -- |
MEGF9 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Megf9tm1Lex for MEGF9
1 MGI phenotypic allele  for Megf9 (no phenotypes)
MEGF9 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MEGF9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MEGF9
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
MEGF9 for ontologies About GeneDecksing
|
Drugs & Compounds
for MEGF9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MEGF9
Search CenterWatch for drugs/clinical trials and news about MEGF9
|
Transcripts
for MEGF9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MEGF9 gene: NM_001080497.2 Unigene Cluster for MEGF9: Multiple EGF-like-domains 9 Hs.494977 [show with all ESTs]Unigene Representative Sequence: NM_0010804972 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000373930(uc022bms.1 uc004bkj.2 uc004bkk.4) ENST00000426959
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEGF9 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEGF9 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MEGF9 (NM_001080497) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MEGF9 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEGF9 |
Additional cDNA sequence: AB011542.1 AJ420444.1 AK295380.1 BC008313.1 BC016989.1 4 DOTS entries: DT.40289140 DT.443017 DT.97762536 DT.101963657 24/165 AceView cDNA sequences (see all 165): AI302757 AW090433 BM479460 BQ441783 BX094496 AI244758 T92590 BM669970 BU738292 CB155129 BF110421 BE465116 BC016989 AI023855 BF445580 AI700974 BM479774 BX496275 BF982842 BM764900 AI278963 BQ718056 CK299466 BC008313
GeneLoc Exon Structure
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Expression
for MEGF9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MEGF9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGAAATCCC
About this image
See MEGF9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MEGF9
SOURCE GeneReport for Unigene cluster: Hs.494977
SABiosciences Custom PCR Arrays for MEGF9
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEGF9
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MEGF9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEGF9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEGF9 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEGF9 |
Orthologs
for MEGF9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MEGF9 gene from 3/11 species (see all 11) About this table
ENSEMBL Gene Tree for MEGF9 (if available)
TreeFam Gene Tree for MEGF9 (if available) |
Paralogs
for MEGF9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MEGF9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: MEGF9_HUMAN, Q9H1U4Polymorphism: The poly-Ala stretch (positions 24 to 31) may be polymorphic and varies from 6 to 8 Ala residues
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MEGF9 (123363091 - 123476748 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MEGF9
1 CNV: 7723
1 Indel: 47640 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEGF9 |
|
Disorders
/ Diseases
for MEGF9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MEGF9 for disorders About GeneDecksing
OMIM gene information: 604268
OMIM disorders: --
1  disease for MEGF9: About MalaCardstetralogy of fallot
1 disease from the University of Copenhagen DISEASES database for MEGF9:Tetralogy of Fallot Export disorders for MEGF9 gene to outside databases
|
Publications
for MEGF9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MEGF9 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MEGF9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of high-molecular-weight proteins with multiple EGF- like motifs by motif-trap screening. (PubMed id 9693030)1, 2, 3 Nakayama M.... Ohara O. (1998)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536)1 Barber M.J....Krauss R.M. (2010)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
- MEGF9: a novel transmembrane protein with a strong and developmentally regulated expression in the nervous system. (PubMed id 16981854)9 Brandt-Bohne U....Koch M. (2007)
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External Searches for MEGF9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MEGF9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MEGF9 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing MEGF9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MEGF9 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MEGF9 gene:
Search GeneIP for patents involving MEGF9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MEGF9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MEGF9 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEGF9 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEGF9 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MEGF9 | | OriGene 3'-UTR Clone for MEGF9 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEGF9 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEGF9 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MEGF9 | | OriGene Custom Protein Services for MEGF9 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MEGF9 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEGF9 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEGF9 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEGF9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEGF9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEGF9 |
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| | | | Search Tocris compounds for MEGF9 |
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 | | | MEGF9 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEGF9 |
|  |  |  | | | | Search ThermoFisher Antibodies for MEGF9 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEGF9 |
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