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Aliases for MEGF9 Gene

Aliases for MEGF9 Gene

  • Multiple EGF Like Domains 9 2 3
  • Multiple EGF-Like-Domains 9 2 3 5
  • Epidermal Growth Factor-Like Protein 5 3 4
  • EGF-Like-Domain, Multiple 5 2 3
  • EGFL5 3 4
  • Multiple EGF-Like Domains Protein 9 4
  • EGF-Like Protein 5 4
  • KIAA0818 4

External Ids for MEGF9 Gene

Previous HGNC Symbols for MEGF9 Gene

  • EGFL5

Previous GeneCards Identifiers for MEGF9 Gene

  • GC09M122402
  • GC09M123363
  • GC09M092980

Summaries for MEGF9 Gene

GeneCards Summary for MEGF9 Gene

MEGF9 (Multiple EGF Like Domains 9) is a Protein Coding gene. An important paralog of this gene is NTN3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEGF9 Gene

Genomics for MEGF9 Gene

Regulatory Elements for MEGF9 Gene

Enhancers for MEGF9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MEGF9 on UCSC Golden Path with GeneCards custom track

Promoters for MEGF9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MEGF9 on UCSC Golden Path with GeneCards custom track

Genomic Location for MEGF9 Gene

120,600,813 bp from pter
120,714,487 bp from pter
113,675 bases
Minus strand

Genomic View for MEGF9 Gene

Genes around MEGF9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEGF9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEGF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEGF9 Gene

Proteins for MEGF9 Gene

  • Protein details for MEGF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Multiple epidermal growth factor-like domains protein 9
    Protein Accession:
    Secondary Accessions:
    • B7Z315
    • O75098

    Protein attributes for MEGF9 Gene

    602 amino acids
    Molecular mass:
    62984 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ88736.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

neXtProt entry for MEGF9 Gene

Proteomics data for MEGF9 Gene at MOPED

Post-translational modifications for MEGF9 Gene

  • Glycosylation at Asn 40, Ser 64, Asn 182, Asn 205, Asn 218, Asn 245, Asn 267, Asn 305, Asn 428, Asn 468, Asn 481, and Asn 500
  • Modification sites at PhosphoSitePlus

Other Protein References for MEGF9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEGF9 Gene

Domains & Families for MEGF9 Gene

Protein Domains for MEGF9 Gene

Suggested Antigen Peptide Sequences for MEGF9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 5 laminin EGF-like domains.
  • Contains 5 laminin EGF-like domains.
genes like me logo Genes that share domains with MEGF9: view

No data available for Gene Families for MEGF9 Gene

Function for MEGF9 Gene

Phenotypes for MEGF9 Gene

GenomeRNAi human phenotypes for MEGF9:
genes like me logo Genes that share phenotypes with MEGF9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MEGF9

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MEGF9 Gene

Localization for MEGF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEGF9 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for MEGF9 Gene COMPARTMENTS Subcellular localization image for MEGF9 gene
Compartment Confidence
extracellular 3
cytosol 2
nucleus 2
plasma membrane 2
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MEGF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MEGF9: view

Pathways & Interactions for MEGF9 Gene

SuperPathways for MEGF9 Gene

No Data Available

Interacting Proteins for MEGF9 Gene

Gene Ontology (GO) - Biological Process for MEGF9 Gene


No data available for Pathways by source and SIGNOR curated interactions for MEGF9 Gene

Drugs & Compounds for MEGF9 Gene

No Compound Related Data Available

Transcripts for MEGF9 Gene

mRNA/cDNA for MEGF9 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(165) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MEGF9 Gene

Multiple EGF-like-domains 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEGF9 Gene

No ASD Table

Relevant External Links for MEGF9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MEGF9 Gene

mRNA expression in normal human tissues for MEGF9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEGF9 Gene

This gene is overexpressed in Whole Blood (x8.4).

Protein differential expression in normal tissues from HIPED for MEGF9 Gene

This gene is overexpressed in Serum (28.3), Adrenal (22.1), and Monocytes (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MEGF9 Gene

SOURCE GeneReport for Unigene cluster for MEGF9 Gene Hs.744903

genes like me logo Genes that share expression patterns with MEGF9: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MEGF9 Gene

Orthologs for MEGF9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MEGF9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MEGF9 35
  • 88.03 (n)
  • 83.89 (a)
MEGF9 36
  • 82 (a)
(Canis familiaris)
Mammalia MEGF9 35
  • 90.63 (n)
  • 90.05 (a)
(Mus musculus)
Mammalia Megf9 35
  • 84.87 (n)
  • 79.56 (a)
Megf9 16
Megf9 36
  • 78 (a)
(Pan troglodytes)
Mammalia MEGF9 35
  • 99.11 (n)
  • 98.16 (a)
MEGF9 36
  • 90 (a)
(Rattus norvegicus)
Mammalia Megf9 35
  • 84.76 (n)
  • 78.89 (a)
(Monodelphis domestica)
Mammalia MEGF9 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia MEGF9 36
  • 61 (a)
(Gallus gallus)
Aves LOC100858115 35
  • 67.77 (n)
  • 69.31 (a)
MEGF9 36
  • 70 (a)
(Anolis carolinensis)
Reptilia MEGF9 36
  • 51 (a)
(Danio rerio)
Actinopterygii LOC560805 35
  • 58.4 (n)
  • 53.92 (a)
MEGF9 36
  • 39 (a)
Species with no ortholog for MEGF9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEGF9 Gene

Gene Tree for MEGF9 (if available)
Gene Tree for MEGF9 (if available)

Paralogs for MEGF9 Gene

Paralogs for MEGF9 Gene

(2) SIMAP similar genes for MEGF9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MEGF9: view

Variants for MEGF9 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MEGF9 Gene

The poly-Ala stretch (positions 24 to 31) may be polymorphic and varies from 6 to 8 Ala residues.

Sequence variations from dbSNP and Humsavar for MEGF9 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs920745 -- 120,667,665(-) TTGAC(A/G)ATATT intron-variant
rs920746 -- 120,667,328(-) TTAGT(A/G)AAATA intron-variant
rs959558 -- 120,606,633(+) GGCTA(C/G)AGATA intron-variant
rs966396 -- 120,691,003(+) TGCAG(C/T)TAATA intron-variant
rs966397 -- 120,691,034(+) TTTGA(A/G)TCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEGF9 Gene

Variant ID Type Subtype PubMed ID
nsv7434 OTHER Inversion 18451855
esv33143 CNV Loss 17666407
nsv831711 CNV Gain 17160897
esv2294531 CNV Deletion 18987734
nsv526071 CNV Loss 19592680

Variation tolerance for MEGF9 Gene

Residual Variation Intolerance Score: 54.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.25% of all genes are more intolerant (likely to be disease-causing)

No data available for Relevant External Links for MEGF9 Gene

Disorders for MEGF9 Gene

Relevant External Links for MEGF9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MEGF9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEGF9 Gene

Publications for MEGF9 Gene

  1. Identification of high-molecular-weight proteins with multiple EGF- like motifs by motif-trap screening. (PMID: 9693030) Nakayama M. … Ohara O. (Genomics 1998) 2 3 4 67
  2. miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-I+, CCNJ, and MEGF9. (PMID: 24098452) Feliciano A. … Lleonart M.E. (PLoS ONE 2013) 3
  3. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber M.J. … Krauss R.M. (PLoS ONE 2010) 3
  4. MEGF9: a novel transmembrane protein with a strong and developmentally regulated expression in the nervous system. (PMID: 16981854) Brandt-Bohne U. … Koch M. (Biochem. J. 2007) 23
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3

Products for MEGF9 Gene

Sources for MEGF9 Gene