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Aliases for MEGF9 Gene

Aliases for MEGF9 Gene

  • Multiple EGF-Like-Domains 9 2 3
  • EGFL5 3 4 6
  • Epidermal Growth Factor-Like Protein 5 3 4
  • EGF-Like-Domain, Multiple 5 2 3
  • Multiple Epidermal Growth Factor-Like Domains Protein 9 3
  • Multiple EGF-Like Domains Protein 9 4
  • EGF-Like Protein 5 4
  • KIAA0818 4

External Ids for MEGF9 Gene

Previous HGNC Symbols for MEGF9 Gene

  • EGFL5

Previous GeneCards Identifiers for MEGF9 Gene

  • GC09M122402
  • GC09M123363
  • GC09M092980

Summaries for MEGF9 Gene

GeneCards Summary for MEGF9 Gene

MEGF9 (Multiple EGF-Like-Domains 9) is a Protein Coding gene. Diseases associated with MEGF9 include atrial heart septal defect and heart septal defect. GO annotations related to this gene include calcium ion binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEGF9 Gene

Genomics for MEGF9 Gene

Regulatory Elements for MEGF9 Gene

Genomic Location for MEGF9 Gene

Start:
120,600,813 bp from pter
End:
120,714,487 bp from pter
Size:
113,675 bases
Orientation:
Minus strand

Genomic View for MEGF9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEGF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEGF9 Gene

Proteins for MEGF9 Gene

  • Protein details for MEGF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1U4-MEGF9_HUMAN
    Recommended name:
    Multiple epidermal growth factor-like domains protein 9
    Protein Accession:
    Q9H1U4
    Secondary Accessions:
    • B7Z315
    • O75098

    Protein attributes for MEGF9 Gene

    Size:
    602 amino acids
    Molecular mass:
    62984 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ88736.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

neXtProt entry for MEGF9 Gene

Proteomics data for MEGF9 Gene at MOPED

Post-translational modifications for MEGF9 Gene

  • Glycosylation at Asn40, Ser64, Asn182, Asn205, Asn218, Asn245, Asn267, Asn305, Asn428, Asn468, Asn481, and Asn500
  • Modification sites at PhosphoSitePlus

Other Protein References for MEGF9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEGF9 Gene

Domains for MEGF9 Gene

Protein Domains for MEGF9 Gene

Suggested Antigen Peptide Sequences for MEGF9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H1U4

UniProtKB/Swiss-Prot:

MEGF9_HUMAN :
  • Q9H1U4
Domain:
  • Contains 5 laminin EGF-like domains.
genes like me logo Genes that share domains with MEGF9: view

No data available for Gene Families for MEGF9 Gene

Function for MEGF9 Gene

Gene Ontology (GO) - Molecular Function for MEGF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with MEGF9: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEGF9

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MEGF9 Gene

Localization for MEGF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEGF9 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEGF9 Gene COMPARTMENTS Subcellular localization image for MEGF9 gene
Compartment Confidence
extracellular 2
plasma membrane 2
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MEGF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MEGF9: view

Pathways for MEGF9 Gene

SuperPathways for MEGF9 Gene

No Data Available

Interacting Proteins for MEGF9 Gene

Gene Ontology (GO) - Biological Process for MEGF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MEGF9: view

No data available for Pathways by source for MEGF9 Gene

Transcripts for MEGF9 Gene

mRNA/cDNA for MEGF9 Gene

Unigene Clusters for MEGF9 Gene

Multiple EGF-like-domains 9:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEGF9

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MEGF9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEGF9 Gene

No ASD Table

Relevant External Links for MEGF9 Gene

GeneLoc Exon Structure for
MEGF9
ECgene alternative splicing isoforms for
MEGF9

Expression for MEGF9 Gene

mRNA expression in normal human tissues for MEGF9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEGF9 Gene

This gene is overexpressed in Whole Blood (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MEGF9 Gene

SOURCE GeneReport for Unigene cluster for MEGF9 Gene Hs.744903

genes like me logo Genes that share expressions with MEGF9: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MEGF9 Gene

Orthologs for MEGF9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MEGF9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEGF9 35
  • 99.11 (n)
  • 98.16 (a)
MEGF9 36
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MEGF9 35
  • 88.03 (n)
  • 83.89 (a)
MEGF9 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEGF9 35
  • 90.63 (n)
  • 90.05 (a)
mouse
(Mus musculus)
Mammalia Megf9 35
  • 84.87 (n)
  • 79.56 (a)
Megf9 16
Megf9 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MEGF9 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEGF9 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Megf9 35
  • 84.76 (n)
  • 78.89 (a)
chicken
(Gallus gallus)
Aves LOC100858115 35
  • 67.77 (n)
  • 69.31 (a)
MEGF9 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEGF9 36
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC560805 35
  • 58.4 (n)
  • 53.92 (a)
MEGF9 36
  • 39 (a)
OneToOne
Species with no ortholog for MEGF9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEGF9 Gene

ENSEMBL:
Gene Tree for MEGF9 (if available)
TreeFam:
Gene Tree for MEGF9 (if available)

Paralogs for MEGF9 Gene

Selected SIMAP similar genes for MEGF9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MEGF9: view

No data available for Paralogs for MEGF9 Gene

Variants for MEGF9 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MEGF9 Gene

Q9H1U4-MEGF9_HUMAN
The poly-Ala stretch (positions 24 to 31) may be polymorphic and varies from 6 to 8 Ala residues

Sequence variations from dbSNP and Humsavar for MEGF9 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs10616 -- 120,601,255(+) TGCAG(C/T)AACAA utr-variant-3-prime
rs920745 -- 120,667,665(-) TTGAC(A/G)ATATT intron-variant
rs920746 -- 120,667,328(-) TTAGT(A/G)AAATA intron-variant
rs959558 -- 120,606,633(+) GGCTA(C/G)AGATA intron-variant
rs966396 -- 120,691,003(+) TGCAG(C/T)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEGF9 Gene

Variant ID Type Subtype PubMed ID
nsv7434 OTHER Inversion 18451855
esv33143 CNV Loss 17666407
nsv831711 CNV Gain 17160897
esv2294531 CNV Deletion 18987734
nsv526071 CNV Loss 19592680

Relevant External Links for MEGF9 Gene

HapMap Linkage Disequilibrium report
MEGF9

Disorders for MEGF9 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for MEGF9 Gene including...

Search for MEGF9 Gene in MalaCards »

(2) University of Copenhagen DISEASES for MEGF9 Gene

genes like me logo Genes that share disorders with MEGF9: view

No data available for UniProtKB/Swiss-Prot for MEGF9 Gene

Publications for MEGF9 Gene

  1. Identification of high-molecular-weight proteins with multiple EGF- like motifs by motif-trap screening. (PMID: 9693030) Nakayama M. … Ohara O. (Genomics 1998) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber M.J. … Krauss R.M. (PLoS ONE 2010) 3
  5. miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-I+, CCNJ, and MEGF9. (PMID: 24098452) Feliciano A. … Lleonart M.E. (PLoS ONE 2013) 3

Products for MEGF9 Gene

Sources for MEGF9 Gene

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