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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MEGF8 Gene

protein-coding   GIFtS: 51
GCID: GC19P042829

multiple EGF-like-domains 8

(Previous names: EGF-like-domain, multiple 4, chromosome 19 open reading...)
(Previous symbols: EGFL4, C19orf49)
 Explore 6 diseases affiliated with
MEGF8 via our new
 Human Malady Compendium 
Biological research products
for MEGF8
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Multiple EGF-Like-Domains 81 2     CRPT22
EGFL41 2 3 5     EGF-Like Domain-Containing Protein 42
C19orf491 2 3     HBV Pre-S2 Binding Protein 12
SBP11 2     Multiple Epidermal Growth Factor-Like Domains Protein 82
EGF-Like-Domain, Multiple 41 2     KIAA08173
Epidermal Growth Factor-Like Protein 42 3     EGF-Like Protein 43
FLJ223651     Multiple EGF-Like Domains Protein 83
Chromosome 19 Open Reading Frame 491     

External Ids:    HGNC: 32331   Entrez Gene: 19542   Ensembl: ENSG000001054297   OMIM: 6042675   UniProtKB: Q7Z7M03   

Export aliases for MEGF8 gene to outside databases

Previous GC identifers: GC19P047521 GC19P039259


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MEGF8:
The protein encoded by this gene is a single-pass type I membrane protein of unknown function that contains several
EGF-like domains, Kelch repeats, and PSI domains. Defects in this gene are a cause of Carpenter syndrome 2. Two
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2012)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MEGF8 gene promoter:
         Bach1   STAT1   NF-1   Elk-1   AP-2gamma   STAT1alpha   HSF2   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMEGF8 promoter sequence
   Search SABiosciences Chromatin IP Primers for MEGF8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEGF8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q12   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

MEGF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEGF8 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P042829:  view genomic region     (about GC identifiers)

Start:
42,829,761 bp from pter      End:
42,882,921 bp from pter
Size:
53,161 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MEGF8_HUMAN, Q7Z7M0 (See protein sequence)
Recommended Name: Multiple epidermal growth factor-like domains protein 8 precursor  
Size: 2845 amino acids; 303100 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=AAP35084.1; Type=Erroneous initiation; Sequence=BAA32469.2; Type=Erroneous initiation;
Secondary accessions: A8KAY0 O75097
Alternative splicing: 2 isoforms:  Q7Z7M0-1   Q7Z7M0-2   

Explore the universe of human proteins at neXtProt for MEGF8: NX_Q7Z7M0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7Z7M0

  • MEGF8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258867.1  NP_001401.2  

    ENSEMBL proteins: 
     ENSP00000334219   ENSP00000251268   ENSP00000367313  

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    Uscn Proteins for MEGF8

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0016021integral to membrane IEA--


    MEGF8 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MEGF8 for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR011043 Gal_Oxase/kelch_b-propeller
     IPR002165 Plexin_repeat
     IPR000742 EG-like_dom
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS

    Graphical View of Domain Structure for InterPro Entry Q7Z7M0

    ProtoNet protein and cluster: Q7Z7M0

    3 Blocks protein families:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB000859 CUB domain
    IPB002049 Laminin-type EGF-like domain


    UniProtKB/Swiss-Prot: MEGF8_HUMAN, Q7Z7M0
    Similarity: Contains 2 CUB domains
    Similarity: Contains 5 EGF-like domains
    Similarity: Contains 12 Kelch repeats
    Similarity: Contains 4 laminin EGF-like domains
    Similarity: Contains 7 PSI domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    hsa-miR-146b-3p hsa-miR-125a-5p hsa-miR-4251 hsa-miR-219-5p hsa-miR-125b hsa-miR-580 hsa-miR-3153 hsa-miR-515-3p
    SwitchGear 3'UTR luciferase reporter plasmidMEGF8 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity NAS--
    GO:0005509calcium ion binding NAS--
    GO:0005515protein binding IPI--


    MEGF8 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MEGF8:
     Decreased Wnt reporter activit 

    Animal Models:
         12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Megf8):
     cardiovascular system  craniofacial  digestive/alimentary  embryogenesis  growth/size 
     hematopoietic system  immune system  limbs/digits/tail  liver/biliary system  muscle 
     renal/urinary system  respiratory system 

    MEGF8 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MEGF8

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/6 Interacting proteins for MEGF8 (Q7Z7M01, 2, 3 ENSP000003342194) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2858454 I2D: score=3 STRING: ENSP00000344782
    ATXN7O152651, 3EBI-947617,EBI-3866216 I2D: score=1 
    CACNA1AO005551, 3EBI-947617,EBI-766279 I2D: score=1 
    ATN1P542592, 3, ENSP000003490764MINT-2858416 MINT-2858435 I2D: score=3 STRING: ENSP00000349076
    TNFP013753I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--


    MEGF8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MEGF8
    Search CenterWatch for drugs/clinical trials and news about MEGF8 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MEGF8 gene (3 alternative transcripts): 
    NM_001271938.1  NM_001410.2  NM_178121.2  

    Unigene Cluster for MEGF8:

    Multiple EGF-like-domains 8
    Hs.132483  [show with all ESTs]
    Unigene Representative Sequence: NM_001271938
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334370(uc002otl.4 uc002otm.4 uc002otn.4) ENST00000251268
    ENST00000378073

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    hsa-miR-146b-3p hsa-miR-125a-5p hsa-miR-4251 hsa-miR-219-5p hsa-miR-125b hsa-miR-580 hsa-miR-3153 hsa-miR-515-3p
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    Additional cDNA sequence: 

    AB011541.2 AF497566.1 AK026018.1 AY280362.1 BC033228.1 BC093649.1 BC111942.1 BC153880.1 

    7 DOTS entries:

    DT.408972  DT.205275  DT.99980582  DT.99982925  DT.100652341  DT.91710985  DT.92421872 

    24/133 AceView cDNA sequences (see all 133):

    CA442957 BQ642973 NM_001410 BQ929439 AI378645 BC033228 BQ060741 AK026018 
    BG760846 AI536592 AV751780 CD514271 BM705530 AF497566 NM_178121 BF941059 
    CB163431 BQ061459 BQ054453 BQ059804 CB122799 AA311518 BU554097 AI452819 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MEGF8    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                              -                                         -                                                   
    SP2:                                                                                                        -                                                   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39 ^ 40a · 40b
    SP1:                                                                                      -                           
    SP2:                                                                                      -                           
    SP3:                                                                                      -           -               
    SP4:                                                                                                                  
    SP5:                                                                                                  -               


    ECgene alternative splicing isoforms for MEGF8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MEGF8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCAGAGGTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MEGF8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MEGF8

    SOURCE GeneReport for Unigene cluster: Hs.132483
        SABiosciences Custom PCR Arrays for MEGF8
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MEGF8 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Megf81 , 5 multiple EGF-like-domains 81, 5 87.08(n)1
    94.33(a)1
      7 (13.75 cM)5
    2698781  NM_001160400.11  NP_001153872.11 
     253171645 
    lizard
    (Anolis carolinensis)
    Reptilia MEGF86
    --
    44(a)
    1 ↔ 1
    GL344259.1(29549-33369)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.152382 Xenopus laevis transcribed sequence with weak similarity more 76.64(n)    BI443358.1 
    zebrafish
    (Danio rerio)
    Actinopterygii megf86
    megf86
    multiple EGF-like-domains 8
    58(a)
    55(a)
    possible ortholog
    possible ortholog
    16(28676899-28688198)
    16(28631246-28686194)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74661 CG7466 47.04(n)
    38.15(a)
      34099  NM_135336.2  NP_609180.2 


    ENSEMBL Gene Tree for MEGF8 (if available)
    TreeFam Gene Tree for MEGF8 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MEGF8 gene
    ATRNL12  ATRN2  
    1 SIMAP similar gene for MEGF8 using alignment to 5 protein entries:     MEGF8_HUMAN (see all proteins):
    LAMA3

    MEGF8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/849 NCBI SNPs in MEGF8 are shown (see all 849    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1474301691,2
    --42828582(+) CCGCCA/CTACCA 2 -- int1 us2k10--------
    rs1996987461,2
    --42828876(+) CCCCGA/TCCCCT 2 -- int1 us2k10--------
    rs1866272181,2
    C,--42828883(+) CCCTCC/TCTCAG 2 -- us2k1 int10--------
    rs759968911,2
    F,--42829271(+) AACTAT/GGTCAG 2 -- ds5001 us2k12Minor allele frequency- G:0.02NA EA 240
    rs730334291,2
    C,F,--42829272(+) ACTATG/ATCAGG 2 -- us2k1 ds50011Minor allele frequency- A:0.12NA 120
    rs1925269871,2
    --42829529(+) CGCATA/GTGTGT 2 -- ds5001 us2k10--------
    rs774833661,2
    --42830118(+) TGTCTA/GTAGGG 1 -- ut510--------
    rs1115367581,2
    C,F,--42830237(+) GCCGTA/TCCCTT 1 -- ut514Minor allele frequency- T:0.13WA CSA 123
    rs1849020621,2
    --42830269(+) GGGACC/TTCTTC 1 -- ut510--------
    rs2012369331,2
    --42830359(+) TACGGA/CCTGTC 1 -- ut510--------

    HapMap Linkage Disequilibrium report for MEGF8 (42829761 - 42882921 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MEGF8
         1 CNV: 5445
    Human Gene Mutation Database (HGMD): MEGF8

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MEGF8 for disorders           About GeneDecksing

    OMIM gene information: 604267    OMIM disorders: --

    6 diseases for MEGF8:    About MalaCards
    macular degeneration    intrahepatic cholangiocarcinoma    cholangiocarcinoma    hepatitis b
    ataxia    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for MEGF8:
    Dextrocardia     Situs inversus

    Export disorders for MEGF8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MEGF8 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with MEGF8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of high-molecular-weight proteins with multiple EGF- like motifs by motif-trap screening. (PubMed id 9693030)1, 2, 3 Nakayama M.... Ohara O. (1998)
    2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Mutations in multidomain protein MEGF8 identify a Carp enter syndrome subtype associated with defective lateralization. (PubMed id 23063620)1 Twigg S.R....Wilkie A.O. (2012)
    5. Proteomic identification of common SCF ubiquitin ligas e FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (2012)
    6. Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (2011)
    7. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
    8. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
    9. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    10. Screening of the genes of hepatitis B virus preS2 interacting proteins. (PubMed id 12546731)1 Lu Y.Y.... Zhang L.X. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1954 HGNC: 3233 AceView: EGFL4andSBP1 Ensembl:ENSG00000105429 euGenes: HUgn1954
    ECgene: MEGF8 H-InvDB: MEGF8

    (According to HUGE)
    About This Section
    HUGE: KIAA0817

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MEGF8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MEGF8 gene:
    Search GeneIP for patents involving MEGF8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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