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MEGF6 Gene

protein-coding   GIFtS: 50
GCID: GC01M003396

Multiple EGF-Like-Domains 6

(Previous names: EGF-like-domain, multiple 3)
(Previous symbol: EGFL3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Multiple EGF-Like-Domains 61 2     Multiple EGF-Like Domains Protein 62 3
EGFL31 2 3 5     EGF-Like Protein 32 3
EGF-Like-Domain, Multiple 31 2     Multiple Epidermal Growth Factor-Like Domains Protein 62
Epidermal Growth Factor-Like Protein 32 3     KIAA08153

External Ids:    HGNC: 32321   Entrez Gene: 19532   Ensembl: ENSG000001625917   OMIM: 6042665   UniProtKB: O750953   

Export aliases for MEGF6 gene to outside databases

Previous GC identifer: GC01M002699


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MEGF6 Gene:
MEGF6 (multiple EGF-like-domains 6) is a protein-coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is LTBP3.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MEGF6 gene promoter:
         HOXA9B   HOXA9   NRSF form 1   NRSF form 2   Meis-1b   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MEGF6 promoter sequence
   Search Chromatin IP Primers for MEGF6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEGF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.3   Ensembl cytogenetic band:  1p36.32   HGNC cytogenetic band: 1p36.3

MEGF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEGF6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M003396:  view genomic region     (about GC identifiers)

Start:
3,404,506 bp from pter      End:
3,528,059 bp from pter
Size:
123,554 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MEGF6_HUMAN, O75095 (See protein sequence)
Recommended Name: Multiple epidermal growth factor-like domains protein 6 precursor  
Size: 1541 amino acids; 161185 Da
Sequence caution: Sequence=BAA32467.2; Type=Erroneous initiation; Sequence=BAE19678.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened; Sequence=BAE19678.1; Type=Frameshift; Positions=1522;
Secondary accessions: Q4AC86 Q5VV39
Alternative splicing: 2 isoforms:  O75095-1   O75095-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MEGF6: NX_O75095

Explore proteomics data for MEGF6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn252, Asn739
  • Modification sites at PhosphoSitePlus

  • See MEGF6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001400.3  
    ENSEMBL proteins: 
     ENSP00000294599   ENSP00000348982   ENSP00000419033   ENSP00000420386  

    MEGF6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MEGF6

     
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    antibodies-online peptides for MEGF6

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    antibodies-online antibodies for MEGF6 (3 products) 

    MEGF6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for MEGF6
    Cloud-Clone Corp. CLIAs for MEGF6
    Search eBioscience for ELISAs for MEGF6 
    antibodies-online kits for MEGF6 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR000742 EG-like_dom
     IPR011489 EMI_domain
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS
     IPR002049 EGF_laminin

    Graphical View of Domain Structure for InterPro Entry O75095

    ProtoNet protein and cluster: O75095

    1 Blocks protein domain: IPB002049 Laminin-type EGF-like domain

    UniProtKB/Swiss-Prot: MEGF6_HUMAN, O75095
    Similarity: Contains 27 EGF-like domains
    Similarity: Contains 1 EMI domain


    Find genes that share domains with MEGF6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with MEGF6           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MEGF6:
     Decreased cilium length after  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MEGF6
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    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate MEGF6:
    hsa-miR-299-5p hsa-miR-29c hsa-miR-29a hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidMEGF6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MEGF6
    Predesigned siRNA for gene silencing in human, mouse, rat MEGF6

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for MEGF6 (see all 7)
    OriGene ORF clones in mouse, rat for MEGF6
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    GenScript: all cDNA clones in your preferred vector: MEGF6 (NM_001409)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEGF6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MEGF6_HUMAN, O75095: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane3
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with MEGF6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MEGF6
    Interactions:

        Search GeneGlobe Interaction Network for MEGF6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for MEGF6 (O750951, 2, 3 ENSP000003489824) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2858397 I2D: score=3 STRING: ENSP00000344782
    ATXN7O152651, 3EBI-947597,EBI-708350 I2D: score=1 
    CACNA1AO005551, 3EBI-947597,EBI-766279 I2D: score=1 
    ATN1P542592, 3, ENSP000003490764MINT-2858359 MINT-2858378 I2D: score=3 STRING: ENSP00000349076
    CRKLP461093, ENSP000003463004I2D: score=1 STRING: ENSP00000346300
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with MEGF6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MEGF6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MEGF6 gene: 
    NM_001409.3  

    Unigene Cluster for MEGF6:

    Multiple EGF-like-domains 6
    Hs.593645  [show with all ESTs]
    Unigene Representative Sequence: NM_001409
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000294599(uc001akk.3) ENST00000356575(uc001akl.3) ENST00000494257
    ENST00000485002 ENST00000491842 ENST00000475790 ENST00000461795
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MEGF6 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate MEGF6:
    hsa-miR-299-5p hsa-miR-29c hsa-miR-29a hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidMEGF6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MEGF6
    Predesigned siRNA for gene silencing in human, mouse, rat MEGF6
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    GenScript: all cDNA clones in your preferred vector: MEGF6 (NM_001409)
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    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MEGF6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MEGF6
      QuantiTect SYBR Green Assays in human, mouse, rat MEGF6
      QuantiFast Probe-based Assays in human, mouse, rat MEGF6

    Additional mRNA sequence: 

    AB011539.2 AB231860.1 AF086226.1 AF086414.1 

    5 DOTS entries:

    DT.407971  DT.40296816  DT.310825  DT.100839197  DT.95348828 

    Selected AceView cDNA sequences (see all 97):

    AF086414 BM972712 CB123871 AI077323 BX102954 AF086226 AI167183 BU501408 
    AI094518 AW769184 AA360986 BM715446 BM673928 AI079393 AI082299 AW780120 
    W07347 BE336695 BM996630 BM712950 AJ709090 BQ448158 BU616343 AB011539 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MEGF6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCAAAACA
    MEGF6 Expression
    About this image


    MEGF6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor
     
     Bone (Muscoskeletal System)
             Endochondral Facial Bones
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor
    MEGF6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MEGF6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.593645
        Custom PCR Arrays for MEGF6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEGF6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MEGF6 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Megf61 , 5 multiple EGF-like-domains 61, 5 75.17(n)1
    73.05(a)1
      4 (83.89 cM)5
    2309711  NM_001162977.11  NP_001156449.11 
     1541707305 
    chicken
    (Gallus gallus)
    Aves MEGF61 multiple EGF-like-domains 6 65.96(n)
    61.32(a)
      419385  XM_004947374.1  XP_004947431.1 
    lizard
    (Anolis carolinensis)
    Reptilia MEGF66
    multiple EGF-like-domains 6
    61(a)
    1 ↔ 1
    GL343629.1(2924-61699)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia megf61 multiple EGF-like-domains 6 59.54(n)
    56.09(a)
      100497257  XM_002933860.2  XP_002933906.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5577641 multiple epidermal growth factor-like domains protein more 58.73(n)
    55.21(a)
      557764  XM_680884.6  XP_685976.6 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y64G10A.71 CELE_Y64G10A.7 47.5(n)
    44.17(a)
      178377  NM_001268874.1  NP_001255803.1 


    ENSEMBL Gene Tree for MEGF6 (if available)
    TreeFam Gene Tree for MEGF6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MEGF6 gene
    LTBP32  HMCN12  SCUBE32  FBLN52  EFEMP12  LTBP42  SCUBE12  EFEMP22  
    LTBP22  LTBP12  HMCN22  FBLN22  FBLN12  SCUBE22  
    11 SIMAP similar genes for MEGF6 using alignment to 3 protein entries:     MEGF6_HUMAN (see all proteins):
    C1R    PROC    NELL2    LDLR    NPNT    MEGF11
    MATN2    FBLN2    MEGF10    PROS1    UMOD

    Find genes that share paralogs with MEGF6           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MEGF6
    PGOHUM00000238263


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MEGF6 (see all 3546)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1144582521,2
    F--3404027(+) TCATGG/AGCAGA 1 -- int11Minor allele frequency- A:0.01WA 118
    rs757102991,2
    F--3404057(+) GGTAAC/TACTAA 1 -- int11Minor allele frequency- T:0.01WA 118
    rs28210421,2
    C,F,A,H--3404201(-) ACACAC/TGGTAC 1 -- int19Minor allele frequency- T:0.23NA WA CSA EA 371
    rs28210411,2
    C,F,A,H--3404227(-) CAATGG/ATAACC 1 -- int128Minor allele frequency- A:0.33NS EA NA WA CSA 2776
    rs1166109391,2
    F--3404228(+) GTTACC/TATTGC 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1137324051,2
    F--3404275(+) GTGCAC/TGTTCA 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1122828991,2
    F--3404356(+) GGGTGC/TGTGTA 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs601684541,2
    C,F--3404359(+) TGCGTG/CTATGT 1 -- int15Minor allele frequency- C:0.17WA CSA NA EA 362
    rs1438929711,2
    --3404378(+) ATTTAC/TAGACT 1 -- int10--------
    rs1486066121,2
    --3404417(+) CAAACA/GCCTGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for MEGF6 (3404506 - 3528059 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MEGF6 (see all 55):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1645766CNV Deletion17803354
    esv2727917CNV Deletion23290073
    esv2728028CNV Deletion23290073
    esv2672292CNV Deletion23128226
    esv1062679CNV Deletion17803354
    esv2727584CNV Deletion23290073
    esv2727695CNV Deletion23290073
    esv2728473CNV Deletion23290073
    esv2727473CNV Deletion23290073
    esv2728139CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MEGF6
    DNA2.0 Custom Variant and Variant Library Synthesis for MEGF6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604266    OMIM disorders: --


    Find genes that share disorders with MEGF6           About GenesLikeMe


    Export disorders for MEGF6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MEGF6 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with MEGF6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of high-molecular-weight proteins with multiple EGF- like motifs by motif-trap screening. (PubMed id 9693030)1, 2, 3 Nakayama M.... Ohara O. (Genomics 1998)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    4. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (Hum. Mol. Genet. 2011)
    5. Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. (PubMed id 20029029)1 Deribe Y.L....Dikic I. (Sci Signal 2009)
    6. Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PubMed id 18654987)1 Thalappilly S....Dusetti N.J. (Proteomics 2008)
    7. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (Cell 2006)
    8. Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly. (PubMed id 12122015)1 Penner A.S....Shipley J.M. (J. Biol. Chem. 2002)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
    10. Evidence of human thrombomodulin domain as a novel angiogenic factor. (PubMed id 15795324)9 Shi C.S....Wu H.L. (Circulation 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1953 HGNC: 3232 AceView: EGFL3 Ensembl:ENSG00000162591 euGenes: HUgn1953
    ECgene: MEGF6 H-InvDB: MEGF6

    (According to HUGE)
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    HUGE: KIAA0815

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MEGF6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MEGF6 gene:
    Search GeneIP for patents involving MEGF6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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