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Aliases for MEGF6 Gene

Aliases for MEGF6 Gene

  • Multiple EGF Like Domains 6 2 3
  • Multiple EGF-Like-Domains 6 2 3 5
  • Epidermal Growth Factor-Like Protein 3 3 4
  • Multiple EGF-Like Domains Protein 6 3 4
  • EGF-Like-Domain, Multiple 3 2 3
  • EGF-Like Protein 3 3 4
  • EGFL3 3 4
  • KIAA0815 4

External Ids for MEGF6 Gene

Previous HGNC Symbols for MEGF6 Gene

  • EGFL3

Previous GeneCards Identifiers for MEGF6 Gene

  • GC01M003396
  • GC01M002699

Summaries for MEGF6 Gene

GeneCards Summary for MEGF6 Gene

MEGF6 (Multiple EGF Like Domains 6) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is MEGF11.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEGF6 Gene

Genomics for MEGF6 Gene

Regulatory Elements for MEGF6 Gene

Enhancers for MEGF6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MEGF6 on UCSC Golden Path with GeneCards custom track

Promoters for MEGF6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MEGF6 on UCSC Golden Path with GeneCards custom track

Genomic Location for MEGF6 Gene

3,487,942 bp from pter
3,624,757 bp from pter
136,816 bases
Minus strand

Genomic View for MEGF6 Gene

Genes around MEGF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEGF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEGF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEGF6 Gene

Proteins for MEGF6 Gene

  • Protein details for MEGF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Multiple epidermal growth factor-like domains protein 6
    Protein Accession:
    Secondary Accessions:
    • Q4AC86
    • Q5VV39

    Protein attributes for MEGF6 Gene

    1541 amino acids
    Molecular mass:
    161185 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA32467.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE19678.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAE19678.1; Type=Frameshift; Positions=1522; Evidence={ECO:0000305};

    Alternative splice isoforms for MEGF6 Gene


neXtProt entry for MEGF6 Gene

Proteomics data for MEGF6 Gene at MOPED

Post-translational modifications for MEGF6 Gene

  • Glycosylation at Asn 252 and Asn 739
  • Modification sites at PhosphoSitePlus

Other Protein References for MEGF6 Gene

No data available for DME Specific Peptides for MEGF6 Gene

Domains & Families for MEGF6 Gene

Suggested Antigen Peptide Sequences for MEGF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 27 EGF-like domains.
  • Contains 27 EGF-like domains.
  • Contains 1 EMI domain.
genes like me logo Genes that share domains with MEGF6: view

No data available for Gene Families for MEGF6 Gene

Function for MEGF6 Gene

genes like me logo Genes that share phenotypes with MEGF6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MEGF6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MEGF6 Gene

Localization for MEGF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEGF6 Gene


Subcellular locations from

Jensen Localization Image for MEGF6 Gene COMPARTMENTS Subcellular localization image for MEGF6 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for MEGF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with MEGF6: view

Pathways & Interactions for MEGF6 Gene

SuperPathways for MEGF6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEGF6 Gene


No data available for Pathways by source and SIGNOR curated interactions for MEGF6 Gene

Drugs & Compounds for MEGF6 Gene

No Compound Related Data Available

Transcripts for MEGF6 Gene

Unigene Clusters for MEGF6 Gene

Multiple EGF-like-domains 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEGF6 Gene

No ASD Table

Relevant External Links for MEGF6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MEGF6 Gene

mRNA expression in normal human tissues for MEGF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEGF6 Gene

This gene is overexpressed in Artery - Aorta (x6.0) and Artery - Coronary (x4.5).

Protein differential expression in normal tissues from HIPED for MEGF6 Gene

This gene is overexpressed in Gallbladder (32.4), Pancreas (22.4), and Fetal heart (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MEGF6 Gene

SOURCE GeneReport for Unigene cluster for MEGF6 Gene Hs.593645

genes like me logo Genes that share expression patterns with MEGF6: view

Protein tissue co-expression partners for MEGF6 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MEGF6 Gene

Orthologs for MEGF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for MEGF6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MEGF6 35
  • 83.7 (n)
  • 81.44 (a)
MEGF6 36
  • 77 (a)
(Canis familiaris)
Mammalia MEGF6 35
  • 83.39 (n)
  • 81.21 (a)
MEGF6 36
  • 76 (a)
(Mus musculus)
Mammalia Megf6 35
  • 75.17 (n)
  • 73.05 (a)
Megf6 16
Megf6 36
  • 76 (a)
(Pan troglodytes)
Mammalia MEGF6 35
  • 97.71 (n)
  • 96.7 (a)
(Rattus norvegicus)
Mammalia Megf6 35
  • 74.88 (n)
  • 72.68 (a)
(Monodelphis domestica)
Mammalia MEGF6 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
(Gallus gallus)
Aves MEGF6 35
  • 65.96 (n)
  • 61.32 (a)
MEGF6 36
  • 60 (a)
(Anolis carolinensis)
Reptilia MEGF6 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia megf6 35
  • 59.54 (n)
  • 56.09 (a)
(Danio rerio)
Actinopterygii LOC557764 35
  • 58.73 (n)
  • 55.21 (a)
megf6a 36
  • 55 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13668 35
(Caenorhabditis elegans)
Secernentea CELE_Y64G10A.7 35
  • 47.5 (n)
  • 44.17 (a)
Y64G10A.7 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for MEGF6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEGF6 Gene

Gene Tree for MEGF6 (if available)
Gene Tree for MEGF6 (if available)

Paralogs for MEGF6 Gene

Paralogs for MEGF6 Gene

(11) SIMAP similar genes for MEGF6 Gene using alignment to 3 proteins: Pseudogenes for MEGF6 Gene

genes like me logo Genes that share paralogs with MEGF6: view

Variants for MEGF6 Gene

Sequence variations from dbSNP and Humsavar for MEGF6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2794340 - 3,579,915(-) GCGCC(A/G)GCCTC reference, missense
rs7553399 - 3,499,885(+) GGCAC(A/C)GCTGC reference, missense
rs4648506 - 3,497,304(+) CAGCG(C/G)CAGGC reference, missense
rs7513275 - 3,595,370(+) GCTGC(A/G)TCCAC reference, missense
rs11585362 - 3,512,044(+) AGCCC(A/G)CGTGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MEGF6 Gene

Variant ID Type Subtype PubMed ID
nsv871581 CNV Loss 21882294
dgv95n71 CNV Loss 21882294
dgv96n71 CNV Loss 21882294
dgv97n71 CNV Loss 21882294
nsv470687 CNV Loss 18288195
dgv12e1 CNV Complex 17122850
dgv99n71 CNV Loss 21882294
dgv101n71 CNV Loss 21882294
dgv102n71 CNV Loss 21882294
nsv871243 CNV Loss 21882294
nsv871334 CNV Gain+Loss 21882294
dgv103n71 CNV Loss 21882294
nsv830203 CNV Loss 17160897
dgv104n71 CNV Loss 21882294
dgv105n71 CNV Loss 21882294
nsv299 CNV Insertion 18451855
dgv7n67 CNV Gain 20364138
nsv825253 CNV Loss 20364138
dgv106n71 CNV Loss 21882294
esv2727473 CNV Deletion 23290073
esv2727584 CNV Deletion 23290073
esv1595391 CNV Insertion 17803354
esv2727695 CNV Deletion 23290073
nsv818333 CNV Loss 17921354
nsv10494 CNV Loss 18304495
nsv519082 CNV Gain 19592680
nsv870784 CNV Loss 21882294
dgv107n71 CNV Loss 21882294
dgv108n71 CNV Loss 21882294
nsv871823 CNV Loss 21882294
nsv871942 CNV Loss 21882294
nsv870516 CNV Gain 21882294
nsv818444 CNV Loss 17921354
dgv109n71 CNV Loss 21882294
dgv110n71 CNV Loss 21882294
esv2727806 CNV Deletion 23290073
esv2727917 CNV Deletion 23290073
esv1003247 CNV Insertion 20482838
esv1491138 CNV Insertion 17803354
esv2470115 CNV Loss 19546169
esv28730 CNV Loss 19812545
esv1062679 CNV Deletion 17803354
esv2728028 CNV Deletion 23290073
esv2728139 CNV Deletion 23290073
esv2672292 CNV Deletion 23128226
esv1072885 CNV Insertion 17803354
nsv160325 CNV Insertion 16902084
esv2728250 CNV Deletion 23290073
esv2728362 CNV Deletion 23290073
nsv160986 CNV Loss 16902084
nsv160621 CNV Loss 16902084
esv2728473 CNV Deletion 23290073
esv1645766 CNV Deletion 17803354
dgv111n71 CNV Loss 21882294
dgv112n71 CNV Loss 21882294

Variation tolerance for MEGF6 Gene

Residual Variation Intolerance Score: 99.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.40; 98.18% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MEGF6 Gene

Disorders for MEGF6 Gene

Relevant External Links for MEGF6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MEGF6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEGF6 Gene

Publications for MEGF6 Gene

  1. Identification of high-molecular-weight proteins with multiple EGF- like motifs by motif-trap screening. (PMID: 9693030) Nakayama M. … Ohara O. (Genomics 1998) 2 3 4 67
  2. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. (PMID: 21078624) Kahle J.J. … Zoghbi H.Y. (Hum. Mol. Genet. 2011) 3
  3. Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. (PMID: 20029029) Deribe Y.L. … Dikic I. (Sci Signal 2009) 3
  4. Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PMID: 18654987) Thalappilly S. … Dusetti N.J. (Proteomics 2008) 3
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3

Products for MEGF6 Gene

Sources for MEGF6 Gene