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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MEGF6 Gene

protein-coding GIFtS: 50
GCID: GC01M003396

multiple EGF-like-domains 6

(Previous names: EGF-like-domain, multiple 3 )
(Previous symbol: EGFL3)

Explore 6 diseases affiliated with
MEGF6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Multiple EGF-Like-Domains 6¹ ²		Multiple EGF-Like Domains Protein 6² ³
EGFL3¹ ² ³ ⁵		EGF-Like Protein 3² ³
EGF-Like-Domain, Multiple 3¹ ²		Multiple Epidermal Growth Factor-Like Domains Protein 6²
Epidermal Growth Factor-Like Protein 3² ³		KIAA0815³

External Ids:	HGNC: 3232¹	Entrez Gene: 1953²	Ensembl: ENSG00000162591⁷	OMIM: 604266⁵	UniProtKB: O75095³

Export aliases for MEGF6 gene to outside databases

Previous GC identifer: GC01M002699

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004350.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MEGF6 gene promoter:
HOXA9B HOXA9 NRSF form 1 NRSF form 2 Meis-1b Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MEGF6 promoter sequence

Search SABiosciences Chromatin IP Primers for MEGF6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEGF6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.3 Ensembl cytogenetic band: 1p36.32 HGNC cytogenetic band: 1p36.3

MEGF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEGF6 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M003396: view genomic region (about GC identifiers)

Start:	3,404,506 bp from pter	End:	3,528,059 bp from pter
Size:	123,554 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MEGF6_HUMAN, O75095 (See protein sequence)

Recommended Name: Multiple epidermal growth factor-like domains protein 6 precursor

Size: 1541 amino acids; 161185 Da

Subcellular location: Secreted (Potential)

Sequence caution: Sequence=BAA32467.2; Type=Erroneous initiation; Sequence=BAE19678.1; Type=Erroneous initiation;

Note=Translation N-terminally shortened; Sequence=BAE19678.1; Type=Frameshift; Positions=1522;

Secondary accessions: Q4AC86 Q5VV39

Alternative splicing: 2 isoforms: O75095-1 O75095-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MEGF6: NX_O75095

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75095

MEGF6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001400.3

ENSEMBL proteins:

ENSP00000419033 ENSP00000294599 ENSP00000348982 ENSP00000420386

Human Recombinant Protein Products for MEGF6:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MEGF6

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005576	extracellular region	IEA	--

MEGF6 for ontologies About GeneDecksing

MEGF6 Antibody Products:

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Assay Products for MEGF6:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for MEGF6
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	Uscn ELISAs and CLIAs for MEGF6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MEGF6 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR000742 EG-like_dom

IPR011489 EMI_domain

IPR000152 EGF-type_Asp/Asn_hydroxyl_site

IPR018097 EGF_Ca-bd_CS

IPR002049 EGF_laminin

Graphical View of Domain Structure for InterPro Entry O75095

ProtoNet protein and cluster: O75095

1 Blocks protein family: IPB002049 Laminin-type EGF-like domain

UniProtKB/Swiss-Prot: MEGF6_HUMAN, O75095

Similarity: Contains 27 EGF-like domains

Similarity: Contains 1 EMI domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	NAS	--
GO:0005515	protein binding	IPI	--

MEGF6 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for MEGF6:

Decreased cilium length after

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MEGF6

miRNA Products:		OriGene 3'-UTR Clone: MEGF6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEGF6
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate MEGF6:
		hsa-miR-299-5p hsa-miR-29c hsa-miR-29a hsa-miR-29b
		SwitchGear 3'UTR luciferase reporter plasmid: MEGF6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEGF6 (see all 4) OriGene shRNA RFP: MEGF6 OriGene siRNA: MEGF6
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEGF6 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEGF6 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEGF6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MEGF6
		Search LifeMap BioReagents cell lines for MEGF6
		Sirion Biotech Customized stable knockdown cell line services for MEGF6 Sirion Biotech Customized inducible knockdown cell line services for MEGF6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEGF6

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MEGF6

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

5/19 Interacting proteins for MEGF6 (O75095^{1, 2, 3} ENSP00000348982⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GFI1B	Q5VTD9²^,³, ENSP00000344782⁴	MINT-2858397 I2D: score=3 STRING: ENSP00000344782
ATXN7	O15265¹^,³	EBI-947597,EBI-3866216 I2D: score=1
CACNA1A	O00555¹^,³	EBI-947597,EBI-766279 I2D: score=1
ATN1	P54259²^,³, ENSP00000349076⁴	MINT-2858359 MINT-2858378 I2D: score=3 STRING: ENSP00000349076
CRKL	P46109³, ENSP00000346300⁴	I2D: score=1 STRING: ENSP00000346300

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

MEGF6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MEGF6
Search CenterWatch for drugs/clinical trials and news about MEGF6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MEGF6 gene:

NM_001409.3

Unigene Cluster for MEGF6:

Multiple EGF-like-domains 6

Hs.593645 [show with all ESTs]

Unigene Representative Sequence: NM_001409

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000485002 ENST00000294599(uc001akk.3) ENST00000356575(uc001akl.3)

ENST00000494257 ENST00000491842 ENST00000475790 ENST00000461795

miRNA Products:		OriGene 3'-UTR Clone: MEGF6 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEGF6
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate MEGF6:
		hsa-miR-299-5p hsa-miR-29c hsa-miR-29a hsa-miR-29b
		SwitchGear 3'UTR luciferase reporter plasmid: MEGF6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEGF6 (see all 4) OriGene shRNA RFP: MEGF6 OriGene siRNA: MEGF6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEGF6
		Sirion Biotech Custom design and validation of potent shRNA sequences against MEGF6

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEGF6 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEGF6 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MEGF6 (NM_001409)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEGF6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEGF6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEGF6 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEGF6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEGF6

Additional cDNA sequence:

AB011539.2 AB231860.1 AF086226.1 AF086414.1

5 DOTS entries:

DT.407971 DT.40296816 DT.310825 DT.100839197 DT.95348828

24/97 AceView cDNA sequences (see all 97):

AI079393 BM673928 BM931757 AI094518 AI082299 AB011539 AW769184 W07347

CB123871 BM996630 AA360986 AI476058 BE336695 BU616343 BU501408 BM715446

BM972712 BX102954 AJ709090 AF086226 BM712950 BE206166 CR615300 AF086414

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MEGF6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATCAAAACA

About this image

MEGF6 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Endochondral Facial Bones

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

See MEGF6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MEGF6

SOURCE GeneReport for Unigene cluster: Hs.593645

SABiosciences Custom PCR Arrays for MEGF6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEGF6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MEGF6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEGF6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEGF6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEGF6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MEGF6 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MEGF6¹	multiple EGF-like-domains 6	67.22(n) 62.84(a)		419385 XM_417548.3 XP_417548.3
lizard (Anolis carolinensis)	Reptilia	MEGF6⁶ --	--	59(a) 36(a)	1 ↔ 1 possible ortholog	GL343629.1(2924-61699) GL343930.1(34156-87357)
zebrafish (Danio rerio)	Actinopterygii	megf6a¹	multiple EGF-like-domains 6a	60.68(n) 57.27(a)		565108 XM_688405.5 XP_693497.5
worm (Caenorhabditis elegans)	Secernentea	CELE_Y64G10A.7¹	Protein Y64G10A.7	47.61(n) 43.87(a)		178377 NM_070336.4 NP_502737.3

ENSEMBL Gene Tree for MEGF6 (if available)
TreeFam Gene Tree for MEGF6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MEGF6 gene

NAGPA² STAB2² STAB1² MEGF10² SCARF2² MEGF11² TNFAIP6² SCARF1²

PEAR1²

6 SIMAP similar genes for MEGF6 using alignment to 3 protein entries: MEGF6_HUMAN (see all proteins):

PROC NELL2 MEGF11 MEGF10 PROS1 PEAR1

MEGF6 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for MEGF6
PGOHUM00000238263

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114458252^1,2		--	3404027(+)	`TCATGG/AGCAGA`	1	--	int¹		1		WA	118
rs75710299^1,2		--	3404057(+)	`GGTAAC/TACTAA`	1	--	int¹		1		WA	118
rs2821042^1,2	C,F,A,H	--	3404201(-)	`ACACAC/TGGTAC`	1	--	int¹		9		NA WA CSA EA	371
rs2821041^1,2	C,F,A,H	--	3404227(-)	`CAATGG/ATAACC`	1	--	int¹		28		NS EA NA WA CSA	2776
rs116610939^1,2		--	3404228(+)	`GTTACC/TATTGC`	1	--	int¹		1		WA	118
rs113732405^1,2		--	3404275(+)	`GTGCAC/TGTTCA`	1	--	int¹		1		CSA	2
rs112282899^1,2		--	3404356(+)	`GGGTGC/TGTGTA`	1	--	int¹		1		CSA	2
rs60168454^1,2	C,F	--	3404359(+)	`TGCGTG/CTATGT`	1	--	int¹		5		WA CSA NA EA	362
rs143892971^1,2		--	3404378(+)	`ATTTAC/TAGACT`	1	--	int¹		0	--	--	--	--
rs148606612^1,2		--	3404417(+)	`CAAACA/GCCTGC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MEGF6 (3404506 - 3528059 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for MEGF6
10 CNVs: 9868 29825 34822 34821 97264 9867 3278 34820 29824 31597
1 Indel: 69579

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEGF6

DNA2.0 Custom Variant and Variant Library Synthesis for MEGF6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MEGF6 for disorders           About GeneDecksing

OMIM gene information: 604266    OMIM disorders: --

6 diseases for MEGF6:    About MalaCards

marfan syndrome macular degeneration neuroendocrine tumor ataxia

pancreatic cancer pancreatitis

Export disorders for MEGF6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MEGF6 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with MEGF6)

Utopia: connect your pdf to the dynamic
world of online information

Identification of high-molecular-weight proteins with multiple EGF- like motifs by motif-trap screening. (PubMed id 9693030)^{1, 2, 3} Nakayama M.... Ohara O. (1998)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)¹ Kahle J.J....Zoghbi H.Y. (2011)
Regulation of epidermal growth factor receptor traffi cking by lysine deacetylase HDAC6. (PubMed id 20029029)¹ Deribe Y.L....Dikic I. (2009)
Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PubMed id 18654987)¹ Thalappilly S....Dusetti N.J. (2008)
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)¹ Lim J.... Zoghbi H.Y. (2006)
Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly. (PubMed id 12122015)¹ Penner A.S....Shipley J.M. (2002)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)
Evidence of human thrombomodulin domain as a novel angiogenic factor. (PubMed id 15795324)⁹ Shi C.S....Wu H.L. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1953	HGNC: 3232	AceView: EGFL3	Ensembl:ENSG00000162591	euGenes: HUgn1953
ECgene: MEGF6	H-InvDB: MEGF6

(According to HUGE)
About This Section

HUGE: KIAA0815

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MEGF6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MEGF6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MEGF6 gene:
Search GeneIP for patents involving MEGF6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	Browse OriGene Antibodies		OriGene shRNA RFP for MEGF6
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEGF6		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEGF6
	OriGene Protein Over-expression Lysate for MEGF6		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for MEGF6		OriGene 3'-UTR Clone for MEGF6
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEGF6		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEGF6
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MEGF6		OriGene Custom Protein Services for MEGF6
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MEGF6
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEGF6
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEGF6
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEGF6
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEGF6
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEGF6

	GenScript Custom Purified and Recombinant Proteins Services for MEGF6		GenScript cDNA clones with any tag delivered in your preferred vector for MEGF6
	GenScript Custom Assay Services for MEGF6		GenScript Custom Superior Antibodies Services for MEGF6
	GenScript Custom overexpressing Cell Line Services for MEGF6		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in MEGF6 promoter
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MEGF6 Proteins, Antibodies, CLIAs, and ELISAs

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEGF6

	SwitchGear 3'UTR luciferase reporter plasmids for MEGF6
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Search ThermoFisher Antibodies for MEGF6

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEGF6

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MEGF6

Sirion Biotech Customized:

	stable knockdown cell line services for MEGF6
	inducible knockdown cell line services for MEGF6
	design and validation of potent shRNA sequences against MEGF6
	adenovirus for potent knockdown of MEGF6
	adenovirus for overexpression of MEGF6
	stable overexpressing cell line services
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MEGF6 gene at Home site.

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MEGF6 Gene

multiple EGF-like-domains 6

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MEGF6 Gene

multiple EGF-like-domains 6

Aliasesfor MEGF6 gene

Summariesfor MEGF6 gene

Genomic Viewsfor MEGF6 gene

Proteinsfor MEGF6 gene

Protein Domains /Familiesfor MEGF6 gene

Functionfor MEGF6 gene

Pathways & Interactionsfor MEGF6 gene

Drugs & Compoundsfor MEGF6 gene

Transcriptsfor MEGF6 gene

Expression for MEGF6 gene

Orthologsfor MEGF6 gene

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Disorders / Diseasesfor MEGF6 gene

Publicationsfor MEGF6 gene

External Searches for MEGF6 gene

Genome Databases showing MEGF6 gene

Other Databases showing MEGF6 gene

Specialized Databases showing MEGF6 gene

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for MEGF6 gene

Summaries
for MEGF6 gene

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for MEGF6 gene

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Families
for MEGF6 gene

Function
for MEGF6 gene

Pathways & Interactions
for MEGF6 gene

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for MEGF6 gene

Transcripts
for MEGF6 gene

Expression
for MEGF6 gene

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Genomic Variants
for MEGF6 gene

Disorders / Diseases
for MEGF6 gene

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for MEGF6 gene

Intellectual Property
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