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Aliases for MEGF11 Gene

Aliases for MEGF11 Gene

  • Multiple EGF Like Domains 11 2 3 5
  • Multiple EGF-Like Domains Protein 11 4
  • Multiple EGF-Like-Domains 11 2
  • KIAA1781 4

External Ids for MEGF11 Gene

Previous GeneCards Identifiers for MEGF11 Gene

  • GC15M061979
  • GC15M059286
  • GC15M063766
  • GC15M063903
  • GC15M063974
  • GC15M066187
  • GC15M043012

Summaries for MEGF11 Gene

GeneCards Summary for MEGF11 Gene

MEGF11 (Multiple EGF Like Domains 11) is a Protein Coding gene. An important paralog of this gene is MEGF10.

UniProtKB/Swiss-Prot for MEGF11 Gene

  • May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEGF11 Gene

Genomics for MEGF11 Gene

Regulatory Elements for MEGF11 Gene

Enhancers for MEGF11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F066172 0.5 FANTOM5 11.5 +81.3 81287 0.1 NFYB ZNF341 ZIC2 MEGF11 SNAPC5 GC15P067136
GH15F066196 0.6 ENCODE 11.3 +56.9 56866 1.1 ZNF692 GLI4 PRDM1 MEGF11 SNAPC5 GC15P067136
GH15F066153 1.3 FANTOM5 ENCODE 11.1 +99.6 99612 0.4 PKNOX1 KLF17 BMI1 FEZF1 GLIS2 SCRT2 KLF7 CREM EGR2 OVOL3 DIS3L MEGF11 GC15P067136
GH15F066141 0.8 FANTOM5 10.7 +112.3 112339 0.2 SCRT1 SCRT2 PRDM2 MEGF11 DENND4A MAP2K1 GC15P067136 GC15M066111
GH15F065954 1 Ensembl ENCODE 10.4 +299.2 299154 1.1 TEAD4 ZIC2 ZFHX2 GATA3 FOS ZNF600 ZBTB20 EGR2 YY2 REST MEGF11 GC15P067909 LOC105370867
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MEGF11 on UCSC Golden Path with GeneCards custom track

Promoters for MEGF11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001796079 647 2201 INSM2 ZNF76 KLF17 ZNF2 RAD21 ZEB1 GLIS2 ZNF366 ZNF143 EGR2

Genomic Location for MEGF11 Gene

Chromosome:
15
Start:
65,895,079 bp from pter
End:
66,253,747 bp from pter
Size:
358,669 bases
Orientation:
Minus strand

Genomic View for MEGF11 Gene

Genes around MEGF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEGF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEGF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEGF11 Gene

Proteins for MEGF11 Gene

  • Protein details for MEGF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6BM72-MEG11_HUMAN
    Recommended name:
    Multiple epidermal growth factor-like domains protein 11
    Protein Accession:
    A6BM72
    Secondary Accessions:
    • Q17R86
    • Q6UXS5
    • Q8ND91
    • Q96KG6

    Protein attributes for MEGF11 Gene

    Size:
    1044 amino acids
    Molecular mass:
    110844 Da
    Quaternary structure:
    • Homopolymer (Probable). Does not interact with MEGF10.
    SequenceCaution:
    • Sequence=BAB47410.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD38994.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MEGF11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEGF11 Gene

Post-translational modifications for MEGF11 Gene

  • Glycosylation at Asn 270 and Asn 531
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MEGF11 Gene

Domains & Families for MEGF11 Gene

Protein Domains for MEGF11 Gene

Suggested Antigen Peptide Sequences for MEGF11 Gene

Graphical View of Domain Structure for InterPro Entry

A6BM72

UniProtKB/Swiss-Prot:

MEG11_HUMAN :
  • Contains 14 EGF-like domains.
  • Belongs to the MEGF family.
Domain:
  • Contains 14 EGF-like domains.
  • Contains 1 EMI domain.
Family:
  • Belongs to the MEGF family.
genes like me logo Genes that share domains with MEGF11: view

No data available for Gene Families for MEGF11 Gene

Function for MEGF11 Gene

Molecular function for MEGF11 Gene

UniProtKB/Swiss-Prot Function:
May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity).
genes like me logo Genes that share phenotypes with MEGF11: view

Animal Models for MEGF11 Gene

MGI Knock Outs for MEGF11:

Animal Model Products

  • Taconic Biosciences Mouse Models for MEGF11

miRNA for MEGF11 Gene

miRTarBase miRNAs that target MEGF11

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEGF11 Gene

Localization for MEGF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEGF11 Gene

Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Note=Forms an irregular, mosaic-like adhesion pattern in region of the cell that becomes firmely fixed to the substrate. Localized to protruding lamellipodia. Does not localize with MEGF10.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEGF11 Gene COMPARTMENTS Subcellular localization image for MEGF11 gene
Compartment Confidence
plasma membrane 5
extracellular 3
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MEGF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with MEGF11: view

Pathways & Interactions for MEGF11 Gene

SuperPathways for MEGF11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEGF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010842 retina layer formation ISS --
GO:0034109 homotypic cell-cell adhesion ISS --
genes like me logo Genes that share ontologies with MEGF11: view

No data available for Pathways by source and SIGNOR curated interactions for MEGF11 Gene

Transcripts for MEGF11 Gene

Unigene Clusters for MEGF11 Gene

Multiple EGF-like-domains 11:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEGF11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23 ^
SP1: - - - - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5:
SP6:
SP7: -
SP8:

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b · 29c ^ 30 ^ 31
SP1: - - - - - - - -
SP2: -
SP3: - - - -
SP4: -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for MEGF11 Gene

GeneLoc Exon Structure for
MEGF11
ECgene alternative splicing isoforms for
MEGF11

Expression for MEGF11 Gene

mRNA expression in normal human tissues for MEGF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEGF11 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x11.9) and Brain - Cerebellum (x11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MEGF11 Gene



NURSA nuclear receptor signaling pathways regulating expression of MEGF11 Gene:

MEGF11

SOURCE GeneReport for Unigene cluster for MEGF11 Gene:

Hs.712886
genes like me logo Genes that share expression patterns with MEGF11: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MEGF11 Gene

Orthologs for MEGF11 Gene

This gene was present in the common ancestor of animals.

Orthologs for MEGF11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEGF11 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia MEGF11 34 35
  • 92.43 (n)
cow
(Bos Taurus)
Mammalia MEGF11 34 35
  • 90.96 (n)
mouse
(Mus musculus)
Mammalia Megf11 34 16 35
  • 89.66 (n)
rat
(Rattus norvegicus)
Mammalia Megf11 34
  • 84.24 (n)
oppossum
(Monodelphis domestica)
Mammalia MEGF11 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEGF11 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves MEGF11 34 35
  • 74.75 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 85 (a)
OneToMany
-- 35
  • 72 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia megf11 34
  • 71.53 (n)
zebrafish
(Danio rerio)
Actinopterygii megf11 34 35
  • 69.88 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007256 34
  • 52.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta drpr 36 34 35
  • 51.5 (n)
CG18172 36
  • 44 (a)
BG:DS00180.14 36
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea ced-1 34 35
  • 46.92 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToMany
Species where no ortholog for MEGF11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEGF11 Gene

ENSEMBL:
Gene Tree for MEGF11 (if available)
TreeFam:
Gene Tree for MEGF11 (if available)

Paralogs for MEGF11 Gene

Paralogs for MEGF11 Gene

(4) SIMAP similar genes for MEGF11 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for MEGF11 Gene

genes like me logo Genes that share paralogs with MEGF11: view

Variants for MEGF11 Gene

Sequence variations from dbSNP and Humsavar for MEGF11 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1001454 -- 66,235,541(-) CATGT(A/C)TCTGG intron-variant
rs1003989 -- 66,214,553(-) TCCCA(C/G)AGGCC intron-variant
rs1003990 -- 66,214,360(-) AGGGA(C/T)GAATT intron-variant
rs10152210 -- 66,077,937(+) AAGGC(C/T)GGGCC intron-variant
rs10152272 -- 66,212,341(+) CACCT(A/T)TCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEGF11 Gene

Variant ID Type Subtype PubMed ID
dgv1228n106 CNV deletion 24896259
esv1121128 CNV insertion 17803354
esv1421197 CNV insertion 17803354
esv2749788 CNV deletion 23290073
esv2749789 CNV deletion 23290073
esv2760035 CNV loss 17122850
esv2761875 CNV gain 21179565
esv3306749 CNV mobile element insertion 20981092
esv3309331 CNV mobile element insertion 20981092
esv3361194 CNV insertion 20981092
esv3405191 CNV duplication 20981092
esv3429747 CNV insertion 20981092
esv3552585 CNV deletion 23714750
esv3581747 CNV loss 25503493
esv3636762 CNV loss 21293372
esv3636765 CNV gain 21293372
esv3636767 CNV loss 21293372
esv5067 CNV loss 18987735
esv987792 CNV deletion 20482838
esv994579 CNV insertion 20482838
nsv1047176 CNV gain 25217958
nsv1047588 CNV loss 25217958
nsv1055090 CNV gain 25217958
nsv1070704 CNV deletion 25765185
nsv1122977 CNV deletion 24896259
nsv114 CNV insertion 15895083
nsv1152514 CNV deletion 26484159
nsv1571 CNV insertion 18451855
nsv1572 CNV deletion 18451855
nsv1573 CNV insertion 18451855
nsv1574 CNV insertion 18451855
nsv471684 CNV gain 15918152
nsv472137 CNV novel sequence insertion 20440878
nsv472331 CNV novel sequence insertion 20440878
nsv472945 CNV novel sequence insertion 20440878
nsv472962 CNV novel sequence insertion 20440878
nsv472973 CNV novel sequence insertion 20440878
nsv473041 CNV novel sequence insertion 20440878
nsv473945 CNV novel sequence insertion 20440878
nsv474014 CNV novel sequence insertion 20440878
nsv474229 CNV novel sequence insertion 20440878
nsv474598 CNV novel sequence insertion 20440878
nsv474666 CNV novel sequence insertion 20440878
nsv474732 CNV novel sequence insertion 20440878
nsv474744 CNV novel sequence insertion 20440878
nsv475266 CNV novel sequence insertion 20440878
nsv475280 CNV novel sequence insertion 20440878
nsv475304 CNV novel sequence insertion 20440878
nsv475465 CNV novel sequence insertion 20440878
nsv475611 CNV novel sequence insertion 20440878
nsv475839 CNV novel sequence insertion 20440878
nsv476899 CNV novel sequence insertion 20440878
nsv476959 CNV novel sequence insertion 20440878
nsv476984 CNV novel sequence insertion 20440878
nsv478528 CNV novel sequence insertion 20440878
nsv478701 CNV novel sequence insertion 20440878
nsv478881 CNV novel sequence insertion 20440878
nsv478949 CNV novel sequence insertion 20440878
nsv478995 CNV novel sequence insertion 20440878
nsv479083 CNV novel sequence insertion 20440878
nsv479116 CNV novel sequence insertion 20440878
nsv479138 CNV novel sequence insertion 20440878
nsv479150 CNV novel sequence insertion 20440878
nsv479270 CNV novel sequence insertion 20440878
nsv479473 CNV novel sequence insertion 20440878
nsv479495 CNV novel sequence insertion 20440878
nsv480211 CNV novel sequence insertion 20440878
nsv480318 CNV novel sequence insertion 20440878
nsv480420 CNV novel sequence insertion 20440878
nsv480483 CNV novel sequence insertion 20440878
nsv480647 CNV novel sequence insertion 20440878
nsv480927 CNV novel sequence insertion 20440878
nsv480928 CNV novel sequence insertion 20440878
nsv481129 CNV novel sequence insertion 20440878
nsv481168 CNV novel sequence insertion 20440878
nsv481173 CNV novel sequence insertion 20440878
nsv481299 CNV novel sequence insertion 20440878
nsv481347 CNV novel sequence insertion 20440878
nsv509572 CNV insertion 20534489
nsv516488 CNV gain+loss 19592680
nsv569793 CNV gain 21841781
nsv833044 CNV loss 17160897
nsv957990 CNV deletion 24416366

Variation tolerance for MEGF11 Gene

Residual Variation Intolerance Score: 86.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.64; 94.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEGF11 Gene

Human Gene Mutation Database (HGMD)
MEGF11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEGF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEGF11 Gene

Disorders for MEGF11 Gene

Relevant External Links for MEGF11

Genetic Association Database (GAD)
MEGF11
Human Genome Epidemiology (HuGE) Navigator
MEGF11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEGF11

No disorders were found for MEGF11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEGF11 Gene

Publications for MEGF11 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 46 64
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 46 64
  4. The mammalian Ced-1 ortholog MEGF10/KIAA1780 displays a novel adhesion pattern. (PMID: 17498693) Suzuki E. … Nakayama M. (Exp. Cell Res. 2007) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for MEGF11 Gene

Sources for MEGF11 Gene

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