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Aliases for MEGF11 Gene

Aliases for MEGF11 Gene

  • Multiple EGF-Like-Domains 11 2 3
  • KIAA1781 4 6
  • Multiple EGF-Like Domains Protein 11 4

External Ids for MEGF11 Gene

Previous GeneCards Identifiers for MEGF11 Gene

  • GC15M061979
  • GC15M059286
  • GC15M063766
  • GC15M063903
  • GC15M063974
  • GC15M066187
  • GC15M043012

Summaries for MEGF11 Gene

GeneCards Summary for MEGF11 Gene

MEGF11 (Multiple EGF-Like-Domains 11) is a Protein Coding gene. An important paralog of this gene is PEAR1.

UniProtKB/Swiss-Prot for MEGF11 Gene

  • May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEGF11 Gene

Genomics for MEGF11 Gene

Regulatory Elements for MEGF11 Gene

Genomic Location for MEGF11 Gene

Start:
65,895,079 bp from pter
End:
66,253,747 bp from pter
Size:
358,669 bases
Orientation:
Minus strand

Genomic View for MEGF11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEGF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEGF11 Gene

Proteins for MEGF11 Gene

  • Protein details for MEGF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6BM72-MEG11_HUMAN
    Recommended name:
    Multiple epidermal growth factor-like domains protein 11
    Protein Accession:
    A6BM72
    Secondary Accessions:
    • Q17R86
    • Q6UXS5
    • Q8ND91
    • Q96KG6

    Protein attributes for MEGF11 Gene

    Size:
    1044 amino acids
    Molecular mass:
    110844 Da
    Quaternary structure:
    • Homopolymer (Probable). Does not interact with MEGF10.
    SequenceCaution:
    • Sequence=BAB47410.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD38994.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MEGF11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEGF11 Gene

Proteomics data for MEGF11 Gene at MOPED

Post-translational modifications for MEGF11 Gene

  • Glycosylation at Asn270 and Asn531
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MEGF11 Gene

Domains for MEGF11 Gene

Protein Domains for MEGF11 Gene

Suggested Antigen Peptide Sequences for MEGF11 Gene

Graphical View of Domain Structure for InterPro Entry

A6BM72

UniProtKB/Swiss-Prot:

MEG11_HUMAN :
  • A6BM72
Domain:
  • Contains 14 EGF-like domains.
  • Contains 1 EMI domain.
Family:
  • Belongs to the MEGF family.
genes like me logo Genes that share domains with MEGF11: view

No data available for Gene Families for MEGF11 Gene

Function for MEGF11 Gene

Molecular function for MEGF11 Gene

UniProtKB/Swiss-Prot Function: May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity).

Gene Ontology (GO) - Molecular Function for MEGF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with MEGF11: view

Phenotypes for MEGF11 Gene

genes like me logo Genes that share phenotypes with MEGF11: view

miRNA for MEGF11 Gene

miRTarBase miRNAs that target MEGF11

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MEGF11 Gene

Localization for MEGF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEGF11 Gene

Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Note=Forms an irregular, mosaic-like adhesion pattern in region of the cell that becomes firmely fixed to the substrate. Localized to protruding lamellipodia. Does not localize with MEGF10.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEGF11 Gene COMPARTMENTS Subcellular localization image for MEGF11 gene
Compartment Confidence
plasma membrane 5
extracellular 3
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MEGF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with MEGF11: view

Pathways for MEGF11 Gene

SuperPathways for MEGF11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEGF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010842 retina layer formation ISS --
GO:0034109 homotypic cell-cell adhesion ISS --
genes like me logo Genes that share ontologies with MEGF11: view

No data available for Pathways by source for MEGF11 Gene

Transcripts for MEGF11 Gene

Unigene Clusters for MEGF11 Gene

Multiple EGF-like-domains 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEGF11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23 ^
SP1: - - - - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5:
SP6:
SP7: -
SP8:

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b · 29c ^ 30 ^ 31
SP1: - - - - - - - -
SP2: -
SP3: - - - -
SP4: -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for MEGF11 Gene

GeneLoc Exon Structure for
MEGF11
ECgene alternative splicing isoforms for
MEGF11

Expression for MEGF11 Gene

mRNA expression in normal human tissues for MEGF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEGF11 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (11.9) and Brain - Cerebellum (11.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MEGF11 Gene

SOURCE GeneReport for Unigene cluster for MEGF11 Gene Hs.712886

genes like me logo Genes that share expressions with MEGF11: view

No data available for mRNA Expression by UniProt/SwissProt for MEGF11 Gene

Orthologs for MEGF11 Gene

This gene was present in the common ancestor of animals.

Orthologs for MEGF11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEGF11 35
  • 99.55 (n)
  • 99.42 (a)
MEGF11 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MEGF11 35
  • 90.96 (n)
  • 94.44 (a)
MEGF11 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEGF11 35
  • 92.43 (n)
  • 95.31 (a)
MEGF11 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Megf11 35
  • 89.66 (n)
  • 93.99 (a)
Megf11 16
Megf11 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MEGF11 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEGF11 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Megf11 35
  • 84.24 (n)
  • 86.77 (a)
chicken
(Gallus gallus)
Aves MEGF11 35
  • 74.75 (n)
  • 77.29 (a)
MEGF11 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 67 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia megf11 35
  • 71.53 (n)
  • 72.17 (a)
zebrafish
(Danio rerio)
Actinopterygii megf11 35
  • 69.88 (n)
  • 68.19 (a)
megf11 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007256 35
  • 52.14 (n)
  • 43.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta drpr 35
  • 51.5 (n)
  • 40.77 (a)
drpr 36
  • 33 (a)
OneToMany
BG:DS00180.14 37
  • 27 (a)
CG18172 37
  • 44 (a)
drpr 37
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea ced-1 35
  • 46.92 (n)
  • 39.53 (a)
ced-1 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for MEGF11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEGF11 Gene

ENSEMBL:
Gene Tree for MEGF11 (if available)
TreeFam:
Gene Tree for MEGF11 (if available)

Paralogs for MEGF11 Gene

Paralogs for MEGF11 Gene

Selected SIMAP similar genes for MEGF11 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for MEGF11 Gene

genes like me logo Genes that share paralogs with MEGF11: view

Variants for MEGF11 Gene

Sequence variations from dbSNP and Humsavar for MEGF11 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs167995 -- 66,054,369(+) TCCAG(A/G)GTCAA intron-variant
rs167996 -- 66,022,112(+) ATGCA(A/G)CGAGA intron-variant
rs167997 -- 66,046,309(+) CATCT(A/G)GACTA intron-variant
rs167998 -- 66,020,946(+) gagat(C/G)gcgcc intron-variant
rs170780 -- 66,057,770(-) TATGA(G/T)GAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEGF11 Gene

Variant ID Type Subtype PubMed ID
nsv833044 CNV Loss 17160897
nsv904323 CNV Loss 21882294
dgv751e1 CNV Complex 17122850
nsv471684 CNV Gain 15918152
nsv509572 CNV Insertion 20534489
nsv1571 CNV Insertion 18451855
nsv1572 CNV Loss 18451855
esv2749788 CNV Deletion 23290073
esv5067 CNV Deletion 18987735
esv987792 CNV Deletion 20482838
esv2749789 CNV Deletion 23290073
nsv1573 CNV Insertion 18451855
nsv114 CNV Insertion 15895083
esv994579 CNV Insertion 20482838
esv1121128 CNV Insertion 17803354
nsv1574 CNV Insertion 18451855
nsv904324 CNV Loss 21882294
nsv516488 CNV Gain+Loss 19592680
esv1421197 CNV Insertion 17803354
esv271025 CNV Insertion 20981092
esv273604 CNV Insertion 20981092

Relevant External Links for MEGF11 Gene

HapMap Linkage Disequilibrium report
MEGF11
Human Gene Mutation Database (HGMD)
MEGF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEGF11 Gene

Disorders for MEGF11 Gene

Relevant External Links for MEGF11

Genetic Association Database (GAD)
MEGF11
Human Genome Epidemiology (HuGE) Navigator
MEGF11
genes like me logo Genes that share disorders with MEGF11: view

No data available for UniProtKB/Swiss-Prot for MEGF11 Gene

Publications for MEGF11 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The mammalian Ced-1 ortholog MEGF10/KIAA1780 displays a novel adhesion pattern. (PMID: 17498693) Suzuki E. … Nakayama M. (Exp. Cell Res. 2007) 3 4
  4. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 48
  5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 48

Products for MEGF11 Gene

  • antibodies-online peptides for MEGF11
  • antibodies-online antibodies for MEGF11
  • antibodies-online kits for MEGF11

Sources for MEGF11 Gene

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