Aliases for MEGF11 Gene
Aliases for MEGF11 Gene
External Ids for MEGF11 Gene
- HGNC: 29635
- Entrez Gene: 84465
- Ensembl: ENSG00000157890
- OMIM: 612454
- UniProtKB: A6BM72
Previous GeneCards Identifiers for MEGF11 Gene
- GC15M061979
- GC15M059286
- GC15M063766
- GC15M063903
- GC15M063974
- GC15M066187
- GC15M043012
Summaries for MEGF11 Gene
GeneCards Summary for MEGF11 Gene
MEGF11 (Multiple EGF Like Domains 11) is a Protein Coding gene. An important paralog of this gene is MEGF10.
UniProtKB/Swiss-Prot for MEGF11 Gene
-
May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEGF11 Gene
Genomics for MEGF11 Gene
Regulatory Elements for MEGF11 Gene
Enhancers for MEGF11 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH15G066153 | 1.5 | FANTOM5 ENCODE dbSUPER | 11.1 | +99.6 | 99612 | 0.4 | PKNOX1 ARNT KLF17 BMI1 FEZF1 GLIS2 SCRT2 KLF7 RELB IKZF2 | DIS3L MEGF11 GC15P067671 |
| GH15G066137 | 0.7 | dbSUPER | 20.9 | +114.7 | 114714 | 2.5 | STAT1 ZNF146 FEZF1 OSR2 PRDM6 POLR2A SMARCA4 ZNF341 BCL6B SCRT2 | MEGF11 GC15P067671 GC15M066111 |
| GH15G065955 | 0.7 | dbSUPER | 15.5 | +295.9 | 295894 | 4.1 | RFX1 SUZ12 HLF RBBP5 ZNF335 ZNF316 ZNF692 MYNN ZNF341 KDM1A | MEGF11 HACD3 LOC105370867 GC15P068400 |
| GH15G065954 | 1 | ENCODE dbSUPER | 10.4 | +299.2 | 299154 | 1.1 | TEAD4 ZIC2 ETS1 ZFHX2 GATA3 ZNF600 FOS ZBTB20 EGR2 YY2 | MEGF11 GC15P068400 LOC105370867 |
| GH15G066172 | 0.8 | FANTOM5 dbSUPER | 11.5 | +81.3 | 81287 | 0.1 | NFYB ZNF341 RELB ZIC2 | MEGF11 SNAPC5 GC15P067671 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MEGF11 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the MEGF11 gene promoter:
Regulatory Element Products
Genomic Location for MEGF11 Gene
- Chromosome:
- 15
- Start:
- 65,895,079 bp from pter
- End:
- 66,253,747 bp from pter
- Size:
- 358,669 bases
- Orientation:
- Minus strand
Genomic View for MEGF11 Gene
Genes around MEGF11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q22.31 by Ensembl
- 15q22.31 by Entrez Gene
- 15q22.31 by HGNC
MEGF11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MEGF11 Gene
Proteins for MEGF11 Gene
-
Protein details for MEGF11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A6BM72-MEG11_HUMAN
- Recommended name:
- Multiple epidermal growth factor-like domains protein 11
- Protein Accession:
- A6BM72
- Q17R86
- Q6UXS5
- Q8ND91
- Q96KG6
Protein attributes for MEGF11 Gene
- Size:
- 1044 amino acids
- Molecular mass:
- 110844 Da
- Quaternary structure:
-
- Homopolymer (Probable). Does not interact with MEGF10.
- SequenceCaution:
-
- Sequence=BAB47410.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD38994.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for MEGF11 Gene
Post-translational modifications for MEGF11 Gene
Other Protein References for MEGF11 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MEGF11
- Novus Biologicals Antibodies for MEGF11
-
Abcam antibodies for MEGF11
- Invitrogen Antibodies for MEGF11
- antibodies-online Antibodies for MEGF11: See all 11
- GeneTex MEGF11 antibody for MEGF11
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MEGF11
- Origene Custom Protein Services for MEGF11
- Novus Biologicals proteins for MEGF11
- Search GeneTex for Proteins for MEGF11
No data available for DME Specific Peptides for MEGF11 Gene
Domains & Families for MEGF11 Gene
Protein Domains for MEGF11 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MEGF11 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
A6BM72- Family:
-
- Belongs to the MEGF family.
No data available for Gene Families for MEGF11 Gene
Function for MEGF11 Gene
Molecular function for MEGF11 Gene
- UniProtKB/Swiss-Prot Function:
- May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity).
Phenotypes for MEGF11 Gene
- MGI mutant phenotypes for MEGF11:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MEGF11:
Animal Models for MEGF11 Gene
- MGI Knock Outs for MEGF11:
-
- Megf11 tm1a(EUCOMM)Wtsi
Animal Model Products
-
Taconic Biosciences Mouse Models for MEGF11
- Cyagen custom Knockout/knockin (KOKI) mouse models for MEGF11
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MEGF11 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MEGF11 gene
- Search ViGene Biosciences for MEGF11
CRISPR Products
-
OriGene CRISPR knockouts for MEGF11
-
Santa Cruz Biotechnology (SCBT) CRISPR for MEGF11
- GenScript: Design CRISPR guide RNA sequences for MEGF11
miRNA for MEGF11 Gene
- miRTarBase miRNAs that target MEGF11
miRNA Products
- Search ViGene Biosciences for MEGF11
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for MEGF11
- Browse OriGene Inhibitory RNA Products For MEGF11
-
ViGene Biosciences ready-to-package AAV shRNAs for MEGF11 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MEGF11
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MEGF11
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for MEGF11
-
ViGene Biosciences adenoviral particle packaged cDNA for MEGF11 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MEGF11 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MEGF11 gene
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEGF11 Gene
Localization for MEGF11 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MEGF11 Gene
- Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Note=Forms an irregular, mosaic-like adhesion pattern in region of the cell that becomes firmely fixed to the substrate. Localized to protruding lamellipodia. Does not localize with MEGF10.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 3 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0016323 | basolateral plasma membrane | IEA | -- |
Pathways & Interactions for MEGF11 Gene
No Data Available
Interacting Proteins for MEGF11 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010842 | retina layer formation | ISS | -- |
| GO:0034109 | homotypic cell-cell adhesion | ISS | -- |
No data available for Pathways by source and SIGNOR curated interactions for MEGF11 Gene
Transcripts for MEGF11 Gene
mRNA/cDNA for MEGF11 Gene
- (7) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (38) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MEGF11 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MEGF11
-
Santa Cruz Biotechnology (SCBT) CRISPR for MEGF11
- GenScript: Design CRISPR guide RNA sequences for MEGF11
miRNA Products
- Search ViGene Biosciences for MEGF11
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for MEGF11
- Browse OriGene Inhibitory RNA Products For MEGF11
-
ViGene Biosciences ready-to-package AAV shRNAs for MEGF11 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MEGF11
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MEGF11
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | · | 21c | ^ | 22 | ^ | 23 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 24 | ^ | 25 | ^ | 26a | · | 26b | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b | · | 29c | ^ | 30 | ^ | 31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | |||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||
| SP4: | - | ||||||||||||||||||||
| SP5: | |||||||||||||||||||||
| SP6: | |||||||||||||||||||||
| SP7: | |||||||||||||||||||||
| SP8: |
Expression for MEGF11 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Mature Horizontal Cells Inner Nuclear Layer
- Cholinergic Amacrine Cells Inner Nuclear Layer
- Cholinergic Amacrine Cells Ganglion Cell Layer
-
Neurons
- Mature Horizontal Cells Inner Nuclear Layer
- Cholinergic Amacrine Cells Inner Nuclear Layer
- Cholinergic Amacrine Cells Ganglion Cell Layer
-
Heart (Cardiovascular System)
- Atrioventricular Node Cells Atrioventricular Node
- Brain (Nervous System)
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for MEGF11 Gene
This gene is overexpressed in Brain - Cerebellar Hemisphere (x11.9) and Brain - Cerebellum (x11.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MEGF11 Gene
NURSA nuclear receptor signaling pathways regulating expression of MEGF11 Gene:
MEGF11SOURCE GeneReport for Unigene cluster for MEGF11 Gene:
Hs.712886Evidence on tissue expression from TISSUES for MEGF11 Gene
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs for MEGF11
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEGF11 Gene
Orthologs for MEGF11 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MEGF11 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | MEGF11 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | MEGF11 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Megf11 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Megf11 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MEGF11 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MEGF11 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MEGF11 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | megf11 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | megf11 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007256 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | drpr 36 34 35 |
|
||
| CG18172 36 |
|
|
|||
| BG:DS00180.14 36 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | ced-1 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for MEGF11 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MEGF11 Gene
(4) SIMAP similar genes for MEGF11 Gene using alignment to 3 proteins:
Pseudogenes.org Pseudogenes for MEGF11 Gene
Variants for MEGF11 Gene
| SNP ID | Clin | Chr 15 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000006473 | -- | 65,985,287(+) | GGTCT(C/T)TGGGA | intron-variant | |
| rs1000009234 | -- | 66,236,284(+) | GCTGC(C/T)GGGCC | intron-variant | |
| rs1000013188 | -- | 66,122,802(+) | GAGAG(A/G)GAGTC | intron-variant | |
| rs1000020435 | -- | 65,899,017(+) | AGTTT(A/T)TGTGC | intron-variant | |
| rs1000026551 | -- | 66,026,001(+) | TGGCT(C/T)CTCAC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1228n106 | CNV | deletion | 24896259 |
| esv1121128 | CNV | insertion | 17803354 |
| esv1421197 | CNV | insertion | 17803354 |
| esv2749788 | CNV | deletion | 23290073 |
| esv2749789 | CNV | deletion | 23290073 |
| esv2760035 | CNV | loss | 17122850 |
| esv2761875 | CNV | gain | 21179565 |
| esv3306749 | CNV | mobile element insertion | 20981092 |
| esv3309331 | CNV | mobile element insertion | 20981092 |
| esv3361194 | CNV | insertion | 20981092 |
| esv3405191 | CNV | duplication | 20981092 |
| esv3429747 | CNV | insertion | 20981092 |
| esv3552585 | CNV | deletion | 23714750 |
| esv3581747 | CNV | loss | 25503493 |
| esv3636762 | CNV | loss | 21293372 |
| esv3636765 | CNV | gain | 21293372 |
| esv3636767 | CNV | loss | 21293372 |
| esv5067 | CNV | loss | 18987735 |
| esv987792 | CNV | deletion | 20482838 |
| esv994579 | CNV | insertion | 20482838 |
| nsv1047176 | CNV | gain | 25217958 |
| nsv1047588 | CNV | loss | 25217958 |
| nsv1055090 | CNV | gain | 25217958 |
| nsv1070704 | CNV | deletion | 25765185 |
| nsv1122977 | CNV | deletion | 24896259 |
| nsv114 | CNV | insertion | 15895083 |
| nsv1152514 | CNV | deletion | 26484159 |
| nsv1571 | CNV | insertion | 18451855 |
| nsv1572 | CNV | deletion | 18451855 |
| nsv1573 | CNV | insertion | 18451855 |
| nsv1574 | CNV | insertion | 18451855 |
| nsv471684 | CNV | gain | 15918152 |
| nsv472137 | CNV | novel sequence insertion | 20440878 |
| nsv472331 | CNV | novel sequence insertion | 20440878 |
| nsv472945 | CNV | novel sequence insertion | 20440878 |
| nsv472962 | CNV | novel sequence insertion | 20440878 |
| nsv472973 | CNV | novel sequence insertion | 20440878 |
| nsv473041 | CNV | novel sequence insertion | 20440878 |
| nsv473945 | CNV | novel sequence insertion | 20440878 |
| nsv474014 | CNV | novel sequence insertion | 20440878 |
| nsv474229 | CNV | novel sequence insertion | 20440878 |
| nsv474598 | CNV | novel sequence insertion | 20440878 |
| nsv474666 | CNV | novel sequence insertion | 20440878 |
| nsv474732 | CNV | novel sequence insertion | 20440878 |
| nsv474744 | CNV | novel sequence insertion | 20440878 |
| nsv475266 | CNV | novel sequence insertion | 20440878 |
| nsv475280 | CNV | novel sequence insertion | 20440878 |
| nsv475304 | CNV | novel sequence insertion | 20440878 |
| nsv475465 | CNV | novel sequence insertion | 20440878 |
| nsv475611 | CNV | novel sequence insertion | 20440878 |
| nsv475839 | CNV | novel sequence insertion | 20440878 |
| nsv476899 | CNV | novel sequence insertion | 20440878 |
| nsv476959 | CNV | novel sequence insertion | 20440878 |
| nsv476984 | CNV | novel sequence insertion | 20440878 |
| nsv478528 | CNV | novel sequence insertion | 20440878 |
| nsv478701 | CNV | novel sequence insertion | 20440878 |
| nsv478881 | CNV | novel sequence insertion | 20440878 |
| nsv478949 | CNV | novel sequence insertion | 20440878 |
| nsv478995 | CNV | novel sequence insertion | 20440878 |
| nsv479083 | CNV | novel sequence insertion | 20440878 |
| nsv479116 | CNV | novel sequence insertion | 20440878 |
| nsv479138 | CNV | novel sequence insertion | 20440878 |
| nsv479150 | CNV | novel sequence insertion | 20440878 |
| nsv479270 | CNV | novel sequence insertion | 20440878 |
| nsv479473 | CNV | novel sequence insertion | 20440878 |
| nsv479495 | CNV | novel sequence insertion | 20440878 |
| nsv480211 | CNV | novel sequence insertion | 20440878 |
| nsv480318 | CNV | novel sequence insertion | 20440878 |
| nsv480420 | CNV | novel sequence insertion | 20440878 |
| nsv480483 | CNV | novel sequence insertion | 20440878 |
| nsv480647 | CNV | novel sequence insertion | 20440878 |
| nsv480927 | CNV | novel sequence insertion | 20440878 |
| nsv480928 | CNV | novel sequence insertion | 20440878 |
| nsv481129 | CNV | novel sequence insertion | 20440878 |
| nsv481168 | CNV | novel sequence insertion | 20440878 |
| nsv481173 | CNV | novel sequence insertion | 20440878 |
| nsv481299 | CNV | novel sequence insertion | 20440878 |
| nsv481347 | CNV | novel sequence insertion | 20440878 |
| nsv509572 | CNV | insertion | 20534489 |
| nsv516488 | CNV | gain+loss | 19592680 |
| nsv569793 | CNV | gain | 21841781 |
| nsv833044 | CNV | loss | 17160897 |
| nsv957990 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
86.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
12.64;
94.55% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for MEGF11 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEGF11 Gene
Disorders for MEGF11 Gene
Relevant External Links for MEGF11
No disorders were found for MEGF11 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEGF11 Gene
Publications for MEGF11 Gene
- Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
- Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 46 64
- Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 46 64
- The mammalian Ced-1 ortholog MEGF10/KIAA1780 displays a novel adhesion pattern. (PMID: 17498693) Suzuki E. … Nakayama M. (Exp. Cell Res. 2007) 3 4 64
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
Products for MEGF11 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for MEGF11
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MEGF11
- Origene Custom Protein Services for MEGF11
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for MEGF11
- Browse OriGene Inhibitory RNA Products For MEGF11
- OriGene qPCR primer pairs for MEGF11
- OriGene CRISPR knockouts for MEGF11
- OriGene ORF clones in human for MEGF11
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MEGF11
- GenScript: Next-day shipping cDNA ORF clone for MEGF11 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for MEGF11
- GenScript Custom Assay Services for MEGF11
- GenScript Custom overexpressing Cell Line Services for MEGF11
- GenScript: Design CRISPR guide RNA sequences for MEGF11
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MEGF11
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for MEGF11
- Novus Biologicals proteins for MEGF11
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for MEGF11
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Taconic Biosciences Mouse Models for MEGF11
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for MEGF11
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- GeneTex MEGF11 antibody for MEGF11
- Search GeneTex for Proteins for MEGF11
- ViGene Biosciences adenoviral particle packaged cDNA for MEGF11 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MEGF11 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MEGF11 gene
- Search ViGene Biosciences for MEGF11
- Horizon Cell Lines for MEGF11
- Cyagen custom Knockout/knockin (KOKI) mouse models for MEGF11
- VectorBuilder custom plasmid, inducible vectors for MEGF11
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MEGF11
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MEGF11 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer