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Aliases for MEGF11 Gene

Aliases for MEGF11 Gene

  • Multiple EGF Like Domains 11 2 3
  • Multiple EGF-Like-Domains 11 2 5
  • Multiple EGF-Like Domains Protein 11 4
  • KIAA1781 4

External Ids for MEGF11 Gene

Previous GeneCards Identifiers for MEGF11 Gene

  • GC15M061979
  • GC15M059286
  • GC15M063766
  • GC15M063903
  • GC15M063974
  • GC15M066187
  • GC15M043012

Summaries for MEGF11 Gene

GeneCards Summary for MEGF11 Gene

MEGF11 (Multiple EGF Like Domains 11) is a Protein Coding gene. An important paralog of this gene is MEGF6.

UniProtKB/Swiss-Prot for MEGF11 Gene

  • May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEGF11 Gene

Genomics for MEGF11 Gene

Regulatory Elements for MEGF11 Gene

Promoters for MEGF11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MEGF11 on UCSC Golden Path with GeneCards custom track

Genomic Location for MEGF11 Gene

Chromosome:
15
Start:
65,895,079 bp from pter
End:
66,253,747 bp from pter
Size:
358,669 bases
Orientation:
Minus strand

Genomic View for MEGF11 Gene

Genes around MEGF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEGF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEGF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEGF11 Gene

Proteins for MEGF11 Gene

  • Protein details for MEGF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6BM72-MEG11_HUMAN
    Recommended name:
    Multiple epidermal growth factor-like domains protein 11
    Protein Accession:
    A6BM72
    Secondary Accessions:
    • Q17R86
    • Q6UXS5
    • Q8ND91
    • Q96KG6

    Protein attributes for MEGF11 Gene

    Size:
    1044 amino acids
    Molecular mass:
    110844 Da
    Quaternary structure:
    • Homopolymer (Probable). Does not interact with MEGF10.
    SequenceCaution:
    • Sequence=BAB47410.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD38994.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MEGF11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEGF11 Gene

Proteomics data for MEGF11 Gene at MOPED

Post-translational modifications for MEGF11 Gene

  • Glycosylation at Asn 270 and Asn 531
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MEGF11 Gene

Domains & Families for MEGF11 Gene

Protein Domains for MEGF11 Gene

Suggested Antigen Peptide Sequences for MEGF11 Gene

Graphical View of Domain Structure for InterPro Entry

A6BM72

UniProtKB/Swiss-Prot:

MEG11_HUMAN :
  • Contains 14 EGF-like domains.
  • Belongs to the MEGF family.
Domain:
  • Contains 14 EGF-like domains.
  • Contains 1 EMI domain.
Family:
  • Belongs to the MEGF family.
genes like me logo Genes that share domains with MEGF11: view

No data available for Gene Families for MEGF11 Gene

Function for MEGF11 Gene

Molecular function for MEGF11 Gene

UniProtKB/Swiss-Prot Function:
May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity).
genes like me logo Genes that share phenotypes with MEGF11: view

Animal Models for MEGF11 Gene

MGI Knock Outs for MEGF11:

Animal Model Products

  • Taconic Biosciences Mouse Models for MEGF11

miRNA for MEGF11 Gene

miRTarBase miRNAs that target MEGF11

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEGF11 Gene

Localization for MEGF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEGF11 Gene

Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Note=Forms an irregular, mosaic-like adhesion pattern in region of the cell that becomes firmely fixed to the substrate. Localized to protruding lamellipodia. Does not localize with MEGF10.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEGF11 Gene COMPARTMENTS Subcellular localization image for MEGF11 gene
Compartment Confidence
plasma membrane 5
extracellular 3
endoplasmic reticulum 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for MEGF11 Gene

Pathways & Interactions for MEGF11 Gene

SuperPathways for MEGF11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEGF11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MEGF11 Gene

Drugs & Compounds for MEGF11 Gene

No Compound Related Data Available

Transcripts for MEGF11 Gene

Unigene Clusters for MEGF11 Gene

Multiple EGF-like-domains 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEGF11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23 ^
SP1: - - - - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5:
SP6:
SP7: -
SP8:

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b · 29c ^ 30 ^ 31
SP1: - - - - - - - -
SP2: -
SP3: - - - -
SP4: -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for MEGF11 Gene

GeneLoc Exon Structure for
MEGF11
ECgene alternative splicing isoforms for
MEGF11

Expression for MEGF11 Gene

mRNA expression in normal human tissues for MEGF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEGF11 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x11.9) and Brain - Cerebellum (x11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MEGF11 Gene



SOURCE GeneReport for Unigene cluster for MEGF11 Gene Hs.712886

genes like me logo Genes that share expression patterns with MEGF11: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MEGF11 Gene

Orthologs for MEGF11 Gene

This gene was present in the common ancestor of animals.

Orthologs for MEGF11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MEGF11 35
  • 90.96 (n)
  • 94.44 (a)
MEGF11 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEGF11 35
  • 92.43 (n)
  • 95.31 (a)
MEGF11 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Megf11 35
  • 89.66 (n)
  • 93.99 (a)
Megf11 16
Megf11 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MEGF11 35
  • 99.55 (n)
  • 99.42 (a)
MEGF11 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Megf11 35
  • 84.24 (n)
  • 86.77 (a)
oppossum
(Monodelphis domestica)
Mammalia MEGF11 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEGF11 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves MEGF11 35
  • 74.75 (n)
  • 77.29 (a)
MEGF11 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 67 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia megf11 35
  • 71.53 (n)
  • 72.17 (a)
zebrafish
(Danio rerio)
Actinopterygii megf11 35
  • 69.88 (n)
  • 68.19 (a)
megf11 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BG:DS00180.14 37
  • 27 (a)
CG18172 37
  • 44 (a)
drpr 37
  • 41 (a)
drpr 35
  • 51.5 (n)
  • 40.77 (a)
drpr 36
  • 33 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007256 35
  • 52.14 (n)
  • 43.97 (a)
worm
(Caenorhabditis elegans)
Secernentea ced-1 35
  • 46.92 (n)
  • 39.53 (a)
ced-1 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for MEGF11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEGF11 Gene

ENSEMBL:
Gene Tree for MEGF11 (if available)
TreeFam:
Gene Tree for MEGF11 (if available)

Paralogs for MEGF11 Gene

Paralogs for MEGF11 Gene

(4) SIMAP similar genes for MEGF11 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for MEGF11 Gene

genes like me logo Genes that share paralogs with MEGF11: view

Variants for MEGF11 Gene

Sequence variations from dbSNP and Humsavar for MEGF11 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs333550 -, - 65,965,070(-) ACAGC(A/G)CTGTG reference, missense
rs16949528 - 66,119,103(+) CTCCG(C/T)TCTCA reference, missense
rs35309197 - 65,929,871(+) AGTCC(A/G)GGCCC reference, missense
rs3803414 - 65,913,866(-) TATTC(C/T)TCATT reference, missense
rs2303374 - 65,898,739(-) AAATA(C/T)ATATG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MEGF11 Gene

Variant ID Type Subtype PubMed ID
nsv833044 CNV Loss 17160897
nsv904323 CNV Loss 21882294
dgv751e1 CNV Complex 17122850
nsv471684 CNV Gain 15918152
nsv509572 CNV Insertion 20534489
nsv1571 CNV Insertion 18451855
nsv1572 CNV Loss 18451855
esv2749788 CNV Deletion 23290073
esv5067 CNV Deletion 18987735
esv987792 CNV Deletion 20482838
esv2749789 CNV Deletion 23290073
nsv1573 CNV Insertion 18451855
nsv114 CNV Insertion 15895083
esv994579 CNV Insertion 20482838
esv1121128 CNV Insertion 17803354
nsv1574 CNV Insertion 18451855
nsv904324 CNV Loss 21882294
nsv516488 CNV Gain+Loss 19592680
esv1421197 CNV Insertion 17803354
esv271025 CNV Insertion 20981092
esv273604 CNV Insertion 20981092

Variation tolerance for MEGF11 Gene

Residual Variation Intolerance Score: 86.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.64; 94.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEGF11 Gene

HapMap Linkage Disequilibrium report
MEGF11
Human Gene Mutation Database (HGMD)
MEGF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEGF11 Gene

Disorders for MEGF11 Gene

Relevant External Links for MEGF11

Genetic Association Database (GAD)
MEGF11
Human Genome Epidemiology (HuGE) Navigator
MEGF11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEGF11

No disorders were found for MEGF11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEGF11 Gene

Publications for MEGF11 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 67
  2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3
  4. The mammalian Ced-1 ortholog MEGF10/KIAA1780 displays a novel adhesion pattern. (PMID: 17498693) Suzuki E. … Nakayama M. (Exp. Cell Res. 2007) 3
  5. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3

Products for MEGF11 Gene

Sources for MEGF11 Gene

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