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MEGF11 Gene

protein-coding GIFtS: 50
GCID: GC15M066187

Multiple EGF-Like-Domains 11

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Multiple EGF-Like-Domains 11¹ ²
Multiple EGF-Like Domains Protein 11² ³
KIAA1781³ ⁵
Multiple Epidermal Growth Factor-Like Domains Protein 11²

External Ids:	HGNC: 29635¹	Entrez Gene: 84465²	Ensembl: ENSG00000157890⁷	OMIM: 612454⁵	UniProtKB: A6BM72³

Export aliases for MEGF11 gene to outside databases

Previous GC identifers: GC15M061979 GC15M059286 GC15M063766 GC15M063903 GC15M063974 GC15M043012

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MEGF11 Gene:

MEGF11 (multiple EGF-like-domains 11) is a protein-coding gene. Diseases associated with MEGF11 include ataxia, and hypertension. An important paralog of this gene is SCARF1.

UniProtKB/Swiss-Prot: MEG11_HUMAN, A6BM72

Function: May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal

neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring

that all parts of the visual field have access to a full set of processing elements (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:

Regulatory transcription factor binding sites in the MEGF11 gene promoter:
GR FAC1 POU2F1 Pax-5 POU2F1a GR-alpha POU6F1 (c2) CUTL1 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MEGF11 promoter sequence

Search Chromatin IP Primers for MEGF11

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEGF11

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.31 Ensembl cytogenetic band: 15q22.31 HGNC cytogenetic band: 15q22.31

MEGF11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEGF11 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M066187: view genomic region (about GC identifiers)

Start:	66,187,417 bp from pter	End:	66,546,085 bp from pter
Size:	358,669 bases	Orientation:	minus strand

1 alternative location:

Chr15-,NW_003315944 5,553-357,692

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MEG11_HUMAN, A6BM72 (See protein sequence)

Recommended Name: Multiple epidermal growth factor-like domains protein 11 precursor

Size: 1044 amino acids; 110844 Da

Subunit: Homopolymer (Probable). Does not interact with MEGF10

Sequence caution: Sequence=BAB47410.2; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=CAD38994.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: Q17R86 Q6UXS5 Q8ND91 Q96KG6

Alternative splicing: 4 isoforms: A6BM72-1 A6BM72-2 A6BM72-3 A6BM72-4

Explore the universe of human proteins at neXtProt for MEGF11: NX_A6BM72

Explore proteomics data for MEGF11 at MOPED

Post-translational modifications:

Glycosylation² at Asn270, Asn531

Modification sites at PhosphoSitePlus

See MEGF11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_115821.2

ENSEMBL proteins:

ENSP00000386908 ENSP00000288745 ENSP00000456118 ENSP00000401400 ENSP00000414475

ENSP00000378987 ENSP00000378976 ENSP00000353919

MEGF11 Human Recombinant Protein Products:

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	Search ThermoFisher Antibodies for MEGF11
	LSBio Antibodies in human, mouse, rat for MEGF11

MEGF11 Assay Products:

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	GenScript Custom Assay Services for MEGF11
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	Cloud-Clone Corp. ELISAs for MEGF11 Cloud-Clone Corp. CLIAs for MEGF11

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:

IPR000742 EG-like_dom

IPR011489 EMI_domain

IPR002049 EGF_laminin

IPR013032 EGF-like_CS

Graphical View of Domain Structure for InterPro Entry A6BM72

ProtoNet protein and cluster: A6BM72

UniProtKB/Swiss-Prot: MEG11_HUMAN, A6BM72

Similarity: Belongs to the MEGF family

Similarity: Contains 14 EGF-like domains

Similarity: Contains 1 EMI domain

MEGF11 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: MEG11_HUMAN, A6BM72

Function: May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal

neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring

that all parts of the visual field have access to a full set of processing elements (By similarity)

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

MEGF11 for ontologies About GeneDecksing

Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Megf11):

nervous system

vision/eye

MEGF11 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MEGF11

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MEGF11

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MEGF11

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MEGF11

miRNA Products:		miRTarBase miRNAs that target MEGF11: hsa-mir-335-5p (MIRT016854)

		Block miRNA regulation of human, mouse, rat MEGF11 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate MEGF11 (see all 53):
		hsa-miR-376b hsa-let-7d hsa-miR-188-5p hsa-miR-128 hsa-let-7a-2* hsa-miR-624 hsa-miR-578 hsa-miR-488

		SwitchGear 3'UTR luciferase reporter plasmid: MEGF11 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MEGF11
		Predesigned siRNA for gene silencing in human, mouse, rat MEGF11

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MEGF11

Clone Products:		OriGene clones in human, mouse for MEGF11 (see all 10) OriGene ORF clones in mouse, rat for MEGF11 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MEGF11 (NM_032445)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEGF11
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEGF11

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

MEG11_HUMAN, A6BM72: Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass

type I membrane protein. Note=Forms an irregular, mosaic-like adhesion pattern in region of the cell that becomes

firmely fixed to the substrate. Localized to protruding lamellipodia. Does not localize with MEGF10

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	5
extracellular	3
endoplasmic reticulum	1
lysosome	1

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Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral component of membrane	IEA	--
GO:0016323	basolateral plasma membrane	IEA	--

MEGF11 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for MEGF11
Interactions:

Search GeneGlobe Interaction Network for MEGF11

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5 Interacting proteins for MEGF11 (A6BM72^{2, 3} ENSP00000386908⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATN1	P54259²^,³, ENSP00000349076⁴	MINT-2877232 MINT-2877251 I2D: score=3 STRING: ENSP00000349076
GULP1	Q9UBP9³, ENSP00000352047⁴	I2D: score=1 STRING: ENSP00000352047
SNX2	O60749³	I2D: score=1
TXNDC5	ENSP00000369081⁴	STRING: ENSP00000369081
PSMB4	ENSP00000290541⁴	STRING: ENSP00000290541

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Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0010842	retina layer formation	ISS	--
GO:0034109	homotypic cell-cell adhesion	ISS	--

MEGF11 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for MEGF11 (MEG11)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MEGF11 gene:

NM_032445.2

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000409699(uc002apn.1) ENST00000288745(uc002apl.2) ENST00000478721

ENST00000490495 ENST00000489275 ENST00000562154 ENST00000493192 ENST00000478590

ENST00000564573 ENST00000455812 ENST00000484618 ENST00000474398 ENST00000469917

ENST00000422354(uc002apm.2) ENST00000395625 ENST00000395614 ENST00000360698

miRNA Products:		Block miRNA regulation of human, mouse, rat MEGF11 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate MEGF11 (see all 53):
		hsa-miR-376b hsa-let-7d hsa-miR-188-5p hsa-miR-128 hsa-let-7a-2* hsa-miR-624 hsa-miR-578 hsa-miR-488

		SwitchGear 3'UTR luciferase reporter plasmid: MEGF11 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MEGF11
		Predesigned siRNA for gene silencing in human, mouse, rat MEGF11

Clone Products:		OriGene clones in human, mouse for MEGF11 (see all 10) OriGene ORF clones in mouse, rat for MEGF11 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MEGF11 (NM_032445)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEGF11
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEGF11

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for MEGF11
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat MEGF11
		QuantiTect SYBR Green Assays in human, mouse, rat MEGF11
		QuantiFast Probe-based Assays in human, mouse, rat MEGF11

Selected AceView cDNA sequences (see all 38):

AL834326 NM_032445 AW131768 AK090663 AA496110 AY358226 BM723031 AB058677

BC029999 BM677486 AI919451 BF529240 AA861104 AA293781 AA496109 AI936445

AI937692 AL044960 AW293834 BF529771 BX090443 AW293880 BF515086 BM563529

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for MEGF11 (see all 8) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18a	·	18b	^	19	^	20	^	21a	·	21b	·	21c	^	22	^	23	^
SP1:							-		-						-																						-						-				-		-		-
SP2:																																											-				-		-		-
SP3:																																															-		-		-
SP4:																																																			-
SP5:

ExUns:	24	^	25	^	26a	·	26b	^	27	^	28	^	29a	·	29b	·	29c	^	30	^	31
SP1:	-		-		-		-		-				-		-		-
SP2:	-
SP3:					-				-						-		-
SP4:	-
SP5:

ECgene alternative splicing isoforms for MEGF11

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MEGF11 expression in normal human tissues (normalized intensities) MEGF11 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

MEGF11 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 4) fully expand


Neurons
Mature Horizontal Cells Inner Nuclear Layer

Eye (Sensory Organs) fully expand to see all 3 entries
Mature Horizontal Cells Inner Nuclear Layer

Heart (Cardiovascular System)
Atrioventricular Node Cells Atrioventricular Node

Testis (Reproductive System)

MEGF11 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

MEGF11 Protein Expression

Custom PCR Arrays for MEGF11

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for MEGF11
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEGF11

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for MEGF11 gene from Selected species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Megf11^{1 , 5}	multiple EGF-like-domains 11^{1, 5}	89.66(n)¹ 93.99(a)¹		9 (34.67 cM)⁵ 214058¹ NM_001134399.1¹ NP_001127871.1¹ 64385626⁵
chicken (Gallus gallus)	Aves	MEGF11¹	multiple EGF-like-domains 11	74.75(n) 77.29(a)		415545 XM_004943900.1 XP_004943957.1
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	Uncharacterized protein (see all 3)	85(a) 72(a) (see all 3)	1 ↔ many 1 ↔ many (see all 3)	GL343921.1(27207-93585) GL343930.1(34104-87478)
tropical clawed frog (Xenopus tropicalis)	Amphibia	megf11¹	multiple EGF-like-domains 11	71.53(n) 72.17(a)		100490321 XM_004912674.1 XP_004912731.1
zebrafish (Danio rerio)	Actinopterygii	megf11¹	multiple EGF-like-domains 11	69.88(n) 68.19(a)		563468 XM_001921905.4 XP_001921940.2
fruit fly (Drosophila melanogaster)	Insecta	CG18172³ drpr¹	draper¹	44(a) (best of 3)³ 51.5(n)¹ 40.77(a)¹		38218¹ NM_001274347.1¹ NP_001261276.1¹
worm (Caenorhabditis elegans)	Secernentea	ced-1¹	ced-1	46.92(n) 39.53(a)		173064 NM_001026602.3 NP_001021773.1

ENSEMBL Gene Tree for MEGF11 (if available)
TreeFam Gene Tree for MEGF11 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for MEGF11 gene

SCARF1² PEAR1² MEGF10² SCARF2²

4 SIMAP similar genes for MEGF11 using alignment to 3 protein entries: MEG11_HUMAN (see all proteins):

MEGF10 MEGF6 PEAR1 EGFEM1P

MEGF11 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for MEGF11
PGOHUM00000246825

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs57789929^1,2	C	--	43321544(+)	`AAAAT-/AAAATAAAATAAAAT/AAA ATAAAATAAAATAAAATAAAATCATCA`	2	--	int¹ cds¹		1		NA	2
rs35024692^1,2	C,F	--	43349296(+)	`TTGGGT/ATTTTT`	1	--	int¹		2		NA	4
rs71447889^1,2	C	--	43349296(+)	`TTGGG-/TT/TTT TTTTT`	1	--	int¹		1		NA	2
rs71860153^1,2	C	--	46332468(+)	`TACCCCT/-CTCTT`	1	--	int¹		1		CSA	2
rs78392362^1,2	C	--	46383312(+)	`TTTTG-/GATTT ATTTA`	1	--	int¹		0	--	--	--	--
rs192900900^1,2		--	66187140(+)	`TGGTGC/TGATCT`	1	--	ds500¹		0	--	--	--	--
rs148817332^1,2	C	--	66187234(+)	`CACCAC/GGCCCG`	1	--	ds500¹		0	--	--	--	--
rs143463549^1,2	C	--	66187238(+)	`AGGCCC/TGGCTA`	1	--	ds500¹		0	--	--	--	--
rs185054566^1,2		--	66187245(+)	`GCTAAG/TTTTTT`	1	--	ds500¹		0	--	--	--	--
rs16949083^1,2	C,F,H	--	66188031(+)	`CTCCTC/GTGTAT`	1	--	ut3¹ ese³ trp³		8		NA NS EA WA	678

HapMap Linkage Disequilibrium report for MEGF11 (66187417 - 66437417 bp, first 250kb of MEGF11)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for MEGF11 (see all 21): About this table

Variant ID	Type	Subtype	PubMed ID
esv5067	CNV	Deletion	18987735
esv987792	CNV	Deletion	20482838
esv2749789	CNV	Deletion	23290073
esv2749788	CNV	Deletion	23290073
nsv1574	CNV	Insertion	18451855
esv273604	CNV	Insertion	20981092
esv1121128	CNV	Insertion	17803354
esv994579	CNV	Insertion	20482838
esv1421197	CNV	Insertion	17803354
nsv509572	CNV	Insertion	20534489

Human Gene Mutation Database (HGMD): MEGF11

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing MEGF11

DNA2.0 Custom Variant and Variant Library Synthesis for MEGF11

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 612454 OMIM disorders: --

7 diseases for MEGF11: About MalaCards

ataxia hypertension retinitis prostate cancer

malaria neuronitis prostatitis

MEGF11 for disorders About GeneDecksing

Genetic Association Database (GAD): MEGF11
Human Genome Epidemiology (HuGE) Navigator: MEGF11 (2 documents)

Export disorders for MEGF11 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MEGF11 gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with MEGF11)

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Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)^{1, 2, 3} Nagase T.... Ohara O. (DNA Res. 2001)
Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)^{1, 4} Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)^{1, 4} Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
The mammalian Ced-1 ortholog MEGF10/KIAA1780 displays a novel adhesion pattern. (PubMed id 17498693)^{1, 2} Suzuki E. and Nakayama M. (Exp. Cell Res. 2007)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (Genome Res. 2003)
A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study. (PubMed id 17903305)⁴ Murabito J.M....Hwang S.J. (BMC Med. Genet. 2007)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (BMC Genomics 2007)
Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)² Zody M.C....Nusbaum C. (Nature 2006)
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)¹ Lim J.... Zoghbi H.Y. (Cell 2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S.... Malek J. (Genome Res. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84465	HGNC: 29635	AceView: MEGF11	Ensembl:ENSG00000157890	euGenes: HUgn84465
ECgene: MEGF11	H-InvDB: MEGF11

(According to HUGE)
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HUGE: KIAA1781

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MEGF11	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MEGF11 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MEGF11 gene:
Search GeneIP for patents involving MEGF11

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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