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Aliases for MEG8 Gene

Subcategory (RNA class) for MEG8 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for MEG8 Gene

  • Maternally Expressed 8, Small Nucleolar RNA Host Gene 2 3 5
  • Small Nucleolar RNA Host Gene 23 (Non-Protein Coding) 2 3
  • Small Nucleolar RNA Host Gene 24 (Non-Protein Coding) 2 3
  • Long Intergenic Non-Protein Coding RNA 24 2 3
  • RNA Imprinted And Accumulated In Nucleus 2 3
  • Maternally Expressed (In Callipyge) 8 2 3
  • Imprinted RNA Near Meg3/Gtl2 2 3
  • Maternally Expressed 8 (Non-Protein Coding) 2
  • LncRNA MicroRNA Megacluster Host Gene 2
  • Small Nucleolar RNA Host Gene 23 2
  • Small Nucleolar RNA Host Gene 24 2
  • LncRNA MicroRNA Megacluster Host 3
  • Non-Protein Coding RNA 24 2
  • NCRNA00024 3
  • LINC00024 3
  • Lnc-MGC 3
  • SNHG23 3
  • SNHG24 3
  • Rian 3
  • Bsr 3
  • Irm 3

External Ids for MEG8 Gene

Previous HGNC Symbols for MEG8 Gene

  • SNHG23
  • SNHG24

Previous GeneCards Identifiers for MEG8 Gene

  • GC00U990903
  • GC14U900551
  • GC14P101361
  • GC14P081542
  • GC14P101227
  • GC14P101799
  • GC14P102092
  • GC14P102328
  • GC14P102498
  • GC14P102675
  • GC14P102847

Summaries for MEG8 Gene

Entrez Gene Summary for MEG8 Gene

  • This gene is located in a cluster of imprinted genes on chromosome 14q32.3. It encodes a a non-protein coding transcript that is preferentially expressed from the maternal allele in skeletal muscle, and appears to be coordinately regulated with other imprinted genes in this region. [provided by RefSeq, Oct 2010]

GeneCards Summary for MEG8 Gene

MEG8 (Maternally Expressed 8, Small Nucleolar RNA Host Gene) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with MEG8 include Temple Syndrome and Finger Agnosia.

Additional gene information for MEG8 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEG8 Gene

Genomics for MEG8 Gene

GeneHancer (GH) Regulatory Elements for MEG8 Gene

Promoters and enhancers for MEG8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I101555 Enhancer 0.8 ENCODE 10.5 +660.9 660876 0.9 HDGF FOXA2 ZNF473 ZSCAN4 BMI1 RAD21 ZNF207 MCM3 RXRA ZIK1 ZNF839 DYNC1H1 WDR20 DIO3OS MEG8 ENSG00000272444 BEGAIN ENSG00000258959 MIR1247 LOC105370674
GH14I101215 Enhancer 0.8 ENCODE 9.5 +322.0 321954 2.8 FOXA2 ARID4B RAD21 ZNF48 ZSCAN9 RARA CREM RXRA CEBPB NR2F2 LOC100128373 SNORD113-3 SNORD113-4 SNORD113-6 SNORD113-7 SNORD113-8 SNORD113-9 MIR543 ENSG00000222185 ENSG00000222095
GH14I101004 Enhancer 0.7 Ensembl ENCODE 10 +110.3 110315 1.9 GATA3 MNT MYC TCF7L2 MIR134 MIR487A MIR154 MIR323B MIR485 MIR496 MIR377 MIR376C MIR300 MIR654
GH14I101096 Enhancer 0.7 FANTOM5 ENCODE 9.4 +203.6 203578 3.2 ATF4 POLR2A JUN MAFK RTL1 LOC105370670 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
GH14I100898 Enhancer 0.9 ENCODE 7.2 +6.3 6275 6 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZSCAN9 RAD21 ARID2 RCOR1 GC14M100899 WDR25 MEG8 LINC02285 ENSG00000275134 GC14P103253 GC14P103222 ENSG00000258399
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MEG8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MEG8 gene promoter:

Genomic Locations for MEG8 Gene

Genomic Locations for MEG8 Gene
chr14:100,894,770-101,027,415
(GRCh38/hg38)
Size:
132,646 bases
Orientation:
Plus strand
chr14:101,361,107-101,402,336
(GRCh37/hg19)

Genomic View for MEG8 Gene

Genes around MEG8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEG8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEG8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEG8 Gene

Proteins for MEG8 Gene

Post-translational modifications for MEG8 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MEG8 Gene

Domains & Families for MEG8 Gene

Gene Families for MEG8 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MEG8: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MEG8 Gene

Function for MEG8 Gene

Phenotypes From GWAS Catalog for MEG8 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MEG8 Gene

Localization for MEG8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEG8 gene
Compartment Confidence
plasma membrane 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MEG8 Gene

Pathways & Interactions for MEG8 Gene

No Data Available

Interacting Proteins for MEG8 Gene

Gene Ontology (GO) - Biological Process for MEG8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MEG8 Gene

Drugs & Compounds for MEG8 Gene

No Compound Related Data Available

Transcripts for MEG8 Gene

mRNA/cDNA for MEG8 Gene

(1) Additional mRNA sequences :
(23) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MEG8 Gene

Maternally expressed 8 (non-protein coding):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEG8 Gene

No ASD Table

Relevant External Links for MEG8 Gene

GeneLoc Exon Structure for
MEG8
ECgene alternative splicing isoforms for
MEG8

Expression for MEG8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEG8 Gene

mRNA differential expression in normal tissues according to GTEx for MEG8 Gene

This gene is overexpressed in Pituitary (x12.1) and Adrenal Gland (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of MEG8 Gene:

MEG8

SOURCE GeneReport for Unigene cluster for MEG8 Gene:

Hs.655789
genes like me logo Genes that share expression patterns with MEG8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEG8 Gene

Orthologs for MEG8 Gene

Evolution for MEG8 Gene

ENSEMBL:
Gene Tree for MEG8 (if available)
TreeFam:
Gene Tree for MEG8 (if available)

No data available for Orthologs for MEG8 Gene

Paralogs for MEG8 Gene

No data available for Paralogs for MEG8 Gene

Variants for MEG8 Gene

Sequence variations from dbSNP and Humsavar for MEG8 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000122182 -- 100,898,196(+) A/T intron_variant
rs1000294360 -- 100,896,901(+) T/TT intron_variant
rs1000568738 -- 100,901,868(+) C/G intron_variant
rs1000583179 -- 100,902,051(+) C/A/T intron_variant
rs1000684754 -- 100,900,466(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MEG8 Gene

Variant ID Type Subtype PubMed ID
dgv1970n100 CNV gain 25217958
dgv1971n100 CNV loss 25217958
dgv1972n100 CNV loss 25217958
dgv1973n100 CNV gain+loss 25217958
dgv1974n100 CNV gain 25217958
dgv1975n100 CNV loss 25217958
dgv1976n100 CNV loss 25217958
esv3635518 CNV gain 21293372
esv3635519 CNV loss 21293372
esv3635520 CNV gain 21293372
nsv1043713 CNV loss 25217958
nsv1052082 CNV loss 25217958
nsv1052082 CNV loss 25217958
nsv1055067 CNV gain 25217958
nsv509550 CNV insertion 20534489
nsv565859 CNV gain 21841781
nsv565859 CNV gain 21841781
nsv952242 CNV deletion 24416366

Additional Variant Information for MEG8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEG8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MEG8 Gene

Disorders for MEG8 Gene

MalaCards: The human disease database

(13) MalaCards diseases for MEG8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
temple syndrome
  • uniparental disomy, maternal, chromosome 14
finger agnosia
mucocele of salivary gland
  • mucous retention cyst of salivary gland
auditory agnosia
israeli tick typhus
  • israeli spotted fever
- elite association - COSMIC cancer census association via MalaCards
Search MEG8 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with MEG8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEG8 Gene

Publications for MEG8 Gene

  1. An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy. (PMID: 27686049) Kato M … Natarajan R (Nature communications 2016) 2 3 58
  2. Identification of tandemly-repeated C/D snoRNA genes at the imprinted human 14q32 domain reminiscent of those at the Prader-Willi/Angelman syndrome region. (PMID: 12045206) Cavaillé J … Bachellerie JP (Human molecular genetics 2002) 2 3 58
  3. Human-ovine comparative sequencing of a 250-kb imprinted domain encompassing the callipyge (clpg) locus and identification of six imprinted transcripts: DLK1, DAT, GTL2, PEG11, antiPEG11, and MEG8. (PMID: 11337479) Charlier C … Georges M (Genome research 2001) 2 3 58
  4. Identification of a new imprinted gene, Rian, on mouse chromosome 12 by fluorescent differential display screening. (PMID: 11481034) Hatada I … Kono T (Journal of biochemistry 2001) 2 3 58
  5. New insights into the imprinted MEG8-DMR in 14q32 and clinical and molecular description of novel patients with Temple syndrome. (PMID: 28635951) Beygo J … Buiting K (European journal of human genetics : EJHG 2017) 3 58

Products for MEG8 Gene

Sources for MEG8 Gene

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