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Aliases for MEG8 Gene

Subcategory (RNA class) for MEG8 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for MEG8 Gene

  • Maternally Expressed 8 (Non-Protein Coding) 2 3 5
  • Long Intergenic Non-Protein Coding RNA 24 2 3
  • RNA Imprinted And Accumulated In Nucleus 2 3
  • Maternally Expressed (In Callipyge) 8 2 3
  • Imprinted RNA Near Meg3/Gtl2 2 3
  • Non-Protein Coding RNA 24 2
  • NCRNA00024 3
  • LINC00024 3
  • Rian 3
  • Bsr 3
  • Irm 3

External Ids for MEG8 Gene

Previous GeneCards Identifiers for MEG8 Gene

  • GC00U990903
  • GC14U900551
  • GC14P101361
  • GC14P081542
  • GC14P101227
  • GC14P101799
  • GC14P102092
  • GC14P102328

Summaries for MEG8 Gene

Entrez Gene Summary for MEG8 Gene

  • This gene is located in a cluster of imprinted genes on chromosome 14q32.3. It encodes a a non-protein coding transcript that is preferentially expressed from the maternal allele in skeletal muscle, and appears to be coordinately regulated with other imprinted genes in this region. [provided by RefSeq, Oct 2010]

GeneCards Summary for MEG8 Gene

MEG8 (Maternally Expressed 8 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with MEG8 include Mucocele Of Salivary Gland and Auditory Agnosia.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEG8 Gene

Genomics for MEG8 Gene

Regulatory Elements for MEG8 Gene

Enhancers for MEG8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F100058 1.2 ENCODE 9.8 -776.8 -776802 4.5 PKNOX1 ZNF133 SIN3A FEZF1 YBX1 RAD21 ZNF207 RCOR1 FOS EGR2 ENSG00000247970 MIR342 SNHG23 MEG8 EVL GC14M100046 ENSG00000258560
GH14F101730 1 ENCODE 9.7 +895.7 895734 3.3 MLX WRNIP1 ZFP64 ARID4B YY1 FOS SP5 ZHX2 JUNB MXD4 RCOR1 PPP2R5C ENSG00000258919 MEG8 LOC105370676
GH14F100987 1.2 FANTOM5 ENCODE 7.3 +153.0 153034 2.8 PKNOX1 JUN ZIC2 FOSL1 ZNF316 FOXK2 FOS NFE2 MAFK TCF7L2 MEG8 SNHG23 DLK1 RTL1 GC14P102654 SNORD114-28
GH14F100833 0.8 Ensembl ENCODE 0.8 +2.5 2527 10.6 BCOR ESRRA ZMYM3 ZIC2 TEAD3 ZFHX2 SCRT2 FOS NFE2 ZNF600 MEG3 MIR493 MIR337 MIR127 MIR431 MIR433 MIR136 RTL1 SNORD112 MIR370
GH14F100849 0.6 Ensembl 0.4 +13.2 13233 0.6 PKNOX1 ZBTB40 ZNF366 SCRT2 FOS EGR2 SP3 USF2 NCOA1 ZEB2 GC14M100850 MEG8
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MEG8 on UCSC Golden Path with GeneCards custom track

Genomic Location for MEG8 Gene

Chromosome:
14
Start:
100,836,269 bp from pter
End:
100,947,194 bp from pter
Size:
110,926 bases
Orientation:
Plus strand

Genomic View for MEG8 Gene

Genes around MEG8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEG8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEG8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEG8 Gene

Proteins for MEG8 Gene

Post-translational modifications for MEG8 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MEG8 Gene

Domains & Families for MEG8 Gene

Gene Families for MEG8 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MEG8: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MEG8 Gene

Function for MEG8 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MEG8 Gene

Localization for MEG8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEG8 Gene COMPARTMENTS Subcellular localization image for MEG8 gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MEG8 Gene

Pathways & Interactions for MEG8 Gene

SuperPathways for MEG8 Gene

No Data Available

Interacting Proteins for MEG8 Gene

Gene Ontology (GO) - Biological Process for MEG8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MEG8 Gene

Transcripts for MEG8 Gene

mRNA/cDNA for MEG8 Gene

(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MEG8 Gene

Maternally expressed 8 (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEG8 Gene

No ASD Table

Relevant External Links for MEG8 Gene

GeneLoc Exon Structure for
MEG8
ECgene alternative splicing isoforms for
MEG8

Expression for MEG8 Gene

mRNA expression in normal human tissues for MEG8 Gene

mRNA differential expression in normal tissues according to GTEx for MEG8 Gene

This gene is overexpressed in Pituitary (x12.1) and Adrenal Gland (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of MEG8 Gene:

MEG8

SOURCE GeneReport for Unigene cluster for MEG8 Gene:

Hs.655789
genes like me logo Genes that share expression patterns with MEG8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MEG8 Gene

Orthologs for MEG8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MEG8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNORD112 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNORD112 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNORD112 35 35
  • 86 (a)
OneToMany
Species where no ortholog for MEG8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MEG8 Gene

ENSEMBL:
Gene Tree for MEG8 (if available)
TreeFam:
Gene Tree for MEG8 (if available)

Paralogs for MEG8 Gene

No data available for Paralogs for MEG8 Gene

Variants for MEG8 Gene

Sequence variations from dbSNP and Humsavar for MEG8 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10135782 -- 100,904,794(+) GAGCT(C/G)TCCTG intron-variant, upstream-variant-2KB
rs1047338 -- 100,898,450(+) AAGTT(G/T)ATTTT intron-variant, downstream-variant-500B
rs10638500 -- 100,896,070(+) GTCTC(-/AA)AAAAA intron-variant, upstream-variant-2KB
rs10660256 -- 100,899,724(+) AAAAA(-/AA)GGACT intron-variant
rs10782494 -- 100,899,228(+) GGGGT(C/T)CACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEG8 Gene

Variant ID Type Subtype PubMed ID
esv3635518 CNV gain 21293372
esv3635519 CNV loss 21293372
nsv1052082 CNV loss 25217958
nsv565859 CNV gain 21841781
nsv952242 CNV deletion 24416366

Relevant External Links for MEG8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEG8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MEG8 Gene

Disorders for MEG8 Gene

MalaCards: The human disease database

(12) MalaCards diseases for MEG8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mucocele of salivary gland
  • mucocele of salivary gland unspecified
auditory agnosia
israeli tick typhus
  • israeli spotted fever
deep angioma
  • deep hemangioma
osgood-schlatter's disease
  • osteochondrosis
- elite association - COSMIC cancer census association via MalaCards
Search MEG8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MEG8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEG8
genes like me logo Genes that share disorders with MEG8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEG8 Gene

Publications for MEG8 Gene

  1. Identification of tandemly-repeated C/D snoRNA genes at the imprinted human 14q32 domain reminiscent of those at the Prader-Willi/Angelman syndrome region. (PMID: 12045206) CavaillAc J. … Bachellerie J.P. (Hum. Mol. Genet. 2002) 2 3 64
  2. Human-ovine comparative sequencing of a 250-kb imprinted domain encompassing the callipyge (clpg) locus and identification of six imprinted transcripts: DLK1, DAT, GTL2, PEG11, antiPEG11, and MEG8. (PMID: 11337479) Charlier C. … Georges M. (Genome Res. 2001) 2 3 64
  3. Identification of a new imprinted gene, Rian, on mouse chromosome 12 by fluorescent differential display screening. (PMID: 11481034) Hatada I. … Kono T. (J. Biochem. 2001) 2 3 64
  4. Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants. (PMID: 12107410) Wistow G. … Peterson K. (Mol. Vis. 2002) 3 64

Products for MEG8 Gene

Sources for MEG8 Gene

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