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Aliases for MEG8 Gene

Subcategory (RNA class) for MEG8 Gene

lncRNA

Quality Score for this RNA gene is

3

Aliases for MEG8 Gene

  • Maternally Expressed 8 (Non-Protein Coding) 2 3
  • Long Intergenic Non-Protein Coding RNA 24 2 3
  • RNA Imprinted And Accumulated In Nucleus 2 3
  • Maternally Expressed (In Callipyge) 8 2 3
  • Imprinted RNA Near Meg3/Gtl2 2 3
  • Non-Protein Coding RNA 24 2
  • NCRNA00024 3
  • LINC00024 3
  • Rian 3
  • Bsr 3
  • Irm 3

External Ids for MEG8 Gene

Previous GeneCards Identifiers for MEG8 Gene

  • GC00U990903
  • GC14U900551
  • GC14P101361
  • GC14P081542

Summaries for MEG8 Gene

Entrez Gene Summary for MEG8 Gene

  • This gene is located in a cluster of imprinted genes on chromosome 14q32.3. It encodes a a non-protein coding transcript that is preferentially expressed from the maternal allele in skeletal muscle, and appears to be coordinately regulated with other imprinted genes in this region. [provided by RefSeq, Oct 2010]

GeneCards Summary for MEG8 Gene

MEG8 (Maternally Expressed 8 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the lncRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEG8 Gene

Genomics for MEG8 Gene

Regulatory Elements for MEG8 Gene

Genomic Location for MEG8 Gene

Start:
100,894,770 bp from pter
End:
100,935,999 bp from pter
Size:
41,230 bases
Orientation:
Plus strand

Genomic View for MEG8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEG8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEG8 Gene

Proteins for MEG8 Gene

Post-translational modifications for MEG8 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MEG8 Gene

Domains for MEG8 Gene

Gene Families for MEG8 Gene

HGNC:
  • LNCRNA :Long non-coding RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MEG8: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MEG8 Gene

Function for MEG8 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MEG8 Gene

Localization for MEG8 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MEG8 Gene

Pathways for MEG8 Gene

SuperPathways for MEG8 Gene

No Data Available

Interacting Proteins for MEG8 Gene

Gene Ontology (GO) - Biological Process for MEG8 Gene

None

No data available for Pathways by source for MEG8 Gene

Transcripts for MEG8 Gene

mRNA/cDNA for MEG8 Gene

(1) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MEG8 Gene

Maternally expressed 8 (non-protein coding):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEG8

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEG8 Gene

No ASD Table

Relevant External Links for MEG8 Gene

GeneLoc Exon Structure for
MEG8
ECgene alternative splicing isoforms for
MEG8

Expression for MEG8 Gene

mRNA expression in normal human tissues for MEG8 Gene

mRNA differential expression in normal tissues according to GTEx for MEG8 Gene

This gene is overexpressed in Pituitary (12.1) and Adrenal Gland (4.0).

SOURCE GeneReport for Unigene cluster for MEG8 Gene Hs.655789

genes like me logo Genes that share expressions with MEG8: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for MEG8 Gene

Orthologs for MEG8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MEG8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNORD112 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNORD112 36
  • 86 (a)
OneToMany
SNORD112 36
  • 75 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SNORD112 36
  • 91 (a)
OneToOne
Species with no ortholog for MEG8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MEG8 Gene

ENSEMBL:
Gene Tree for MEG8 (if available)
TreeFam:
Gene Tree for MEG8 (if available)

Paralogs for MEG8 Gene

No data available for Paralogs for MEG8 Gene

Variants for MEG8 Gene

Sequence variations from dbSNP and Humsavar for MEG8 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs752041 -- 100,900,995(-) CGGCC(C/T)TGGCA intron-variant
rs755488 -- 100,892,840(-) ATCAC(A/G)CCTGA upstream-variant-2KB
rs755830 -- 100,903,313(-) CTCAC(G/T)CTTGG intron-variant
rs941573 -- 100,902,779(+) CTGGC(G/T)TGAAG intron-variant
rs1047344 -- 100,899,508(+) CAGCA(A/T)TCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEG8 Gene

Variant ID Type Subtype PubMed ID
nsv902241 CNV Loss 21882294

Relevant External Links for MEG8 Gene

HapMap Linkage Disequilibrium report
MEG8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEG8 Gene

Disorders for MEG8 Gene

No disorders were found for MEG8 Gene.

No data available for UniProtKB/Swiss-Prot for MEG8 Gene

Publications for MEG8 Gene

  1. Human-ovine comparative sequencing of a 250-kb imprinted domain encompassing the callipyge (clpg) locus and identification of six imprinted transcripts: DLK1, DAT, GTL2, PEG11, antiPEG11, and MEG8. (PMID: 11337479) Charlier C. … Georges M. (Genome Res. 2001) 2 3
  2. Identification of a new imprinted gene, Rian, on mouse chromosome 12 by fluorescent differential display screening. (PMID: 11481034) Hatada I. … Kono T. (J. Biochem. 2001) 2 3
  3. Identification of tandemly-repeated C/D snoRNA genes at the imprinted human 14q32 domain reminiscent of those at the Prader-Willi/Angelman syndrome region. (PMID: 12045206) CavaillAc J. … Bachellerie J.P. (Hum. Mol. Genet. 2002) 2 3
  4. Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants. (PMID: 12107410) Wistow G. … Peterson K. (Mol. Vis. 2002) 3

Products for MEG8 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MEG8
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MEG8
    • Block miRNA regulation of MEG8 using miScript Target Protectors

    Sources for MEG8 Gene

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