Subcategory (RNA class) for MEG3 Gene
Quality Score for this RNA gene is
Aliases for MEG3 Gene
External Ids for MEG3 Gene
ORGUL Members for MEG3 Gene
Previous GeneCards Identifiers for MEG3 Gene
This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor suppressor. [provided by RefSeq, Mar 2012]
GeneCards Summary for MEG3 Gene
MEG3 (Maternally Expressed 3 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with MEG3 include temple syndrome and uniparental disomy, paternal, chromosome 14.
fRNAdb sequence ontologies for MEG3 Gene - the ORGUL cluster for this gene includes several descriptions:
nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.
antisense_RNA: Antisense RNA is RNA that is transcribed from the coding, rather than the template, strand of DNA. It is therefore complementary to mRNA.
mature_transcript: A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.