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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MEG3 Gene

RNA gene   GIFtS: 34
GCID: GC14P101245

maternally expressed 3 (non-protein coding)

(Previous name: maternally expressed 3 )
 Explore 11 diseases affiliated with
MEG3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MEG3    

Aliases
for MEG3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 3

Aliases
Maternally Expressed 3 (Non-Protein Coding)1 2     FP5042
GTL21 2 5     PRO05182
LINC000231 2     PRO21602
NCRNA000231 2     Prebp11
Maternally Expressed 31     

External Ids:    HGNC: 145751   Entrez Gene: 553842   Ensembl: ENSG000002145487   OMIM: 6056365   UniProtKB: Q9UI563   

Export aliases for MEG3 gene to outside databases

Previous GC identifers: GC14P098688 GC14P095112 GC14P099282 GC14P099287 GC14P099285 GC14P100363 GC14P100364 GC14P100368 GC14P100371 GC14P100373 GC14P101292 GC14P081473


Summaries
for MEG3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MEG3:
This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been
transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal
tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell
proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its
deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor
suppressor. (provided by RefSeq, Mar 2012)

Gene Wiki entry for MEG3


Genomic Views
for MEG3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MEG3 gene promoter:
         Max1   CREB   deltaCREB   Olf-1   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MEG3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.2

MEG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEG3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P101245:  view genomic region     (about GC identifiers)

Start:
 101,245,747 bp from pter      End:
 101,327,368 bp from pter
Size:
 81,622 bases      Orientation:
 plus strand

Proteins
for MEG3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: YYY4_HUMAN, Q9UI56 (See protein sequence)
Recommended Name: Very putative protein from MEG3 locus  
Size: 68 amino acids; 7791 Da
Caution: Product of a dubious gene prediction. There is no evidence of expression of this protein. The MEG3 (Maternally
Expressed) gene probably encodes for a RNA

Explore the universe of human proteins at neXtProt for MEG3: NX_Q9UI56

MEG3 Protein expression data from MOPED and PaxDb: --

Human Recombinant Protein Products for MEG3: 

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Protein Domains /
Families
for MEG3 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q9UI56


Function
for MEG3 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Phenotypes:
     8 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Meg3):
 cellular  embryogenesis  growth/size  homeostasis/metabolism  liver/biliary system 
 mortality/aging  muscle  respiratory system 

MEG3 for phenotypes           About GeneDecksing

Animal Models:
     Mouse knock-outs for MEG3: Meg3tm1Itl Meg3tm1Kono
   inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MEG3 

miRNA
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Inhib. RNA
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Gene Editing
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Cell Line
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In Situ Assay
Products:   
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Pathways & Interactions
for MEG3 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MEG3

Drugs & Compounds
for MEG3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MEG3
Search CenterWatch for drugs/clinical trials and news about MEG3 

Transcripts
for MEG3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for MEG3:

Maternally expressed 3 (non-protein coding)
Hs.654863  [show with all ESTs]
Unigene Representative Sequence: NR_046473
18/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
ENST00000556407(lincRNA) ENST00000429159(lincRNA)(uc010txe.2 uc010txd.2 uc010avz.2 uc010txf.2 uc001yib.3)
ENST00000520714(lincRNA) ENST00000522771(lincRNA) ENST00000424076(lincRNA)(uc021sbw.1) ENST00000423456(lincRNA)(uc001yhy.3)
ENST00000521404(lincRNA) ENST00000556736(lincRNA)(uc001yhz.3 uc010txg.2) ENST00000451743(lincRNA)(uc001yhw.3 uc010txb.2)
ENST00000398518(lincRNA) ENST00000554639(lincRNA)(uc010txc.2 uc001yie.3) ENST00000452120(lincRNA)
ENST00000519709(lincRNA)(uc010txh.2) ENST00000412736(lincRNA)(uc001yic.3) ENST00000455286(lincRNA)
ENST00000523671(lincRNA) ENST00000452514(lincRNA) ENST00000398474(lincRNA)(uc021sbx.1 uc001yid.2)


miRNA
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Inhib. RNA
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Primer
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEG3

Additional cDNA sequence: 

AB032607.1 AF052114.1 AK092707.1 AK098378.1 AK124580.1 AY314975.1 BC036602.1 BC036882.1 
BC062783.1 BC092509.1 BX161432.1 BX161452.1 BX247998.1 BX248012.1 GQ183494.1 GQ183495.1 
GQ183496.1 GQ183497.1 GQ183498.1 GQ183499.1 GQ183500.1 GQ183501.1 GQ183502.1 GQ183503.1 
NR_002766.2 NR_003530.2 NR_003531.3 NR_033358.1 NR_033359.1 NR_033360.1 NR_046464.1 NR_046465.2 
NR_046466.1 NR_046467.1 NR_046468.2 NR_046469.1 NR_046470.2 NR_046471.1 NR_046472.1 NR_046473.1 

24/85 DOTS entries (see all 85):

DT.100892831  DT.97812871  DT.95196617  DT.455127  DT.95103845  DT.100892857  DT.95207522  DT.455076 
DT.100803337  DT.97764803  DT.100771275  DT.100045101  DT.100833667  DT.95196716  DT.91961664  DT.95366306 
DT.101985491  DT.95196719  DT.100045099  DT.307796  DT.97816231  DT.100892843  DT.100837676  DT.100892870 

24/976 AceView cDNA sequences (see all 976):

BI913162 BM510493 AA297065 BE669505 BU784805 CR612108 BQ716711 AA351773 
CR603291 CR615599 AL035808 BQ270798 AI018638 BX462855 BF057815 CR597219 
BU790470 AF052114 CR608797 BX438953 BX371175 BQ270557 CR609941 AI870856 

GeneLoc Exon Structure


Expression
for MEG3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for MEG3:none

MEG3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGATTGTCAT
MEG3 Expression
About this image

MEG3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

9 LifeMap In Vivo Development Anatomical Compartments/Cells 
Tissue Anatomical Compartment CellCategory (developmental path)
EyeInner Nuclear LayerMature Rod Bipolar CellsBipolar, Retina
HeartCardiac CrescentCardiac Crescent CellsMyocardium
TestisSeminiferous TubulesSertoli cellsTestis
BoneMandibular CondyleBone
BoneMandibular ProcessBone
BoneZeugopod Epiphyseal EndBone
KidneyMetanephrosKidney
KidneyRenal Collecting Duct SystemKidney
Reproductive SystemMesonephrosReproductive System
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

Genevestigator expression for MEG3

SOURCE GeneReport for Unigene cluster: Hs.654863
    SABiosciences Custom PCR Arrays for MEG3
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In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEG3

Orthologs
for MEG3 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of human and mouse.

Orthologs for MEG3 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
mouse
(Mus musculus)		 Mammalia Meg35 maternally expressed 3   --   12 (60.25 cM) 109541001 


ENSEMBL Gene Tree for MEG3 (if available)
TreeFam Gene Tree for MEG3 (if available) 

Paralogs
for MEG3 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

Genomic Variants
for MEG3 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/665 NCBI SNPs in MEG3 are shown (see all 665)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 14 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs733475901,2
C--81471375(+) CGTCAA/GCTCAT 16 -- us2k12Minor allele frequency- G:0.04WA 120
rs793936411,2
C--81472215(+) NNNNTC/AACCTG 16 -- us2k14Minor allele frequency- A:0.05CSA WA NA 241
rs777648931,2
--81473106(+) GCACCG/CGCGAC 16 -- us2k11Minor allele frequency- C:0.50CSA 2
rs128824971,2
H--81473297(+) CCCTTC/ATGCGC 16 -- us2k14Minor allele frequency- A:0.00NS EA 418
rs455460401,2
--81473434(+) TCACCC/TGGTGA 16 -- nc-transcript-variant1Minor allele frequency- T:0.01WA 118
rs726987621,2
C,F--81474883(+) TGTGGC/AGAAGG 16 -- int11Minor allele frequency- A:0.04NA 120
rs769430631,2
F--81475083(+) TGGATT/CGACGA 16 -- int11Minor allele frequency- C:0.09WA 118
rs796120001,2
C--81475623(+) CCTCCC/GCCTCC 16 -- int12Minor allele frequency- G:0.09WA 120
rs115400271,2
H--81476383(+) TAAAGA/TCTTAA 16 -- nc-transcript-variant4Minor allele frequency- T:0.00NS EA 404
rs454702941,2
--81476530(+) GGGGGC/TGTCAG 16 -- nc-transcript-variant0--------

HapMap Linkage Disequilibrium report for MEG3 (101245747 - 101327368 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MEG3
     1 CNV: 8776

SABiosciences Cancer Mutation PCR Assays
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Disorders / Diseases
for MEG3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
MEG3 for disorders           About GeneDecksing

OMIM gene information: 605636    OMIM disorders: --

11 diseases for MEG3:    About MalaCards
maternal uniparental disomy, chromosome 14    acute myeloid leukemia    pituitary adenoma    myeloid leukemia
pituitary tumor    myelodysplastic syndrome    seminoma    adenoma
hepatocellular cancer    meningioma    leukemia

1 disease from the University of Copenhagen DISEASES database for MEG3:
Seminoma

Export disorders for MEG3 gene to outside databases

Publications
for MEG3 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MEG3 gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with MEG3)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. (PubMed id 10759892)1, 2, 3, 9 Miyoshi N.... Ishino F. (2000)
  2. Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. (PubMed id 15644399)1, 9 Zhao J....Klibanski A. (2005)
  3. Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes. (PubMed id 18176563)1, 9 Kagami M.... Ogata T. (2008)
  4. Expression of cell growth negative regulators MEG3 and GADD45g is lost in most sporadic human pituitary adenomas. (PubMed id 21850407)1 Mezzomo L.C....Kohek M.B. (2012)
  5. MEG3 noncoding RNA: a tumor suppressor. (PubMed id 22393162)1 Zhou Y....Klibanski A. (2012)
  6. Overexpression of the long non-coding RNA MEG3 impairs in vitro glioma cell proliferation. (PubMed id 22234798)1 Wang P....Sun P. (2012)
  7. microRNA-29 can regulate expression of the long non-c oding RNA gene MEG3 in hepatocellular cancer. (PubMed id 21625215)1 Braconi C....Patel T. (2011)
  8. Silencing of the imprinted DLK1-MEG3 locus in human c linically nonfunctioning pituitary adenomas. (PubMed id 21871428)1 Cheunsuchon P....Klibanski A. (2011)
  9. Maternally expressed gene 3, an imprinted noncoding R NA gene, is associated with meningioma pathogenesis and progression. (PubMed id 20179190)1 Zhang X....Klibanski A. (2010)
  10. The IG-DMR and the MEG3-DMR at human chromosome 14q32 .2: hierarchical interaction and distinct functional properties as imprinting c ontrol centers. (PubMed id 20585555)1 Kagami M....Ogata T. (2010)

External Searches for MEG3 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing MEG3 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 55384 HGNC: 14575 AceView: MEG3 Ensembl:ENSG00000214548 euGenes: HUgn55384
ECgene: MEG3 H-InvDB: MEG3

Other Databases showing MEG3 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing MEG3 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MEG3 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MEG3 Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property
for MEG3 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MEG3 gene:
Search GeneIP for patents involving MEG3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for MEG3 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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