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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MEG3 Gene

RNA gene   GIFtS: 34
GCID: GC14P101245

maternally expressed 3 (non-protein coding)

(Previous name: maternally expressed 3 )
 Explore 11 diseases affiliated with
MEG3 via our new
 Human Malady Compendium 
Biological research products
for MEG3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 3

Aliases
Maternally Expressed 3 (Non-Protein Coding)1 2     FP5042
GTL21 2 5     PRO05182
LINC000231 2     PRO21602
NCRNA000231 2     Prebp11
Maternally Expressed 31     

External Ids:    HGNC: 145751   Entrez Gene: 553842   Ensembl: ENSG000002145487   OMIM: 6056365   UniProtKB: Q9UI563   

Export aliases for MEG3 gene to outside databases

Previous GC identifers: GC14P098688 GC14P095112 GC14P099282 GC14P099287 GC14P099285 GC14P100363 GC14P100364 GC14P100368 GC14P100371 GC14P100373 GC14P101292 GC14P081473


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MEG3:
This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been
transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal
tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell
proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its
deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor
suppressor. (provided by RefSeq, Mar 2012)

Gene Wiki entry for MEG3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MEG3 gene promoter:
         Max1   CREB   deltaCREB   Olf-1   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MEG3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.2

MEG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEG3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P101245:  view genomic region     (about GC identifiers)

Start:
101,245,747 bp from pter      End:
101,327,368 bp from pter
Size:
81,622 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: YYY4_HUMAN, Q9UI56 (See protein sequence)
Recommended Name: Very putative protein from MEG3 locus  
Size: 68 amino acids; 7791 Da
Caution: Product of a dubious gene prediction. There is no evidence of expression of this protein. The MEG3 (Maternally
Expressed) gene probably encodes for a RNA

Explore the universe of human proteins at neXtProt for MEG3: NX_Q9UI56

MEG3 Protein expression data from MOPED and PaxDb: --

Human Recombinant Protein Products: 

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OriGene Custom Protein Services for MEG3 
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Browse Proteins at Uscn


MEG3 Antibody Products: 
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OriGene Custom Antibody Services for MEG3 
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Search for Antibodies for MEG3 at Abcam  
Browse Antibodies at Uscn
Search ThermoFisher Antibodies for MEG3

Assay Products for MEG3: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Immunoassay Development
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GenScript Custom Assay Services for MEG3
Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q9UI56


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA
Products:
    
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Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEG3
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MEG3
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEG3

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for MEG3

Clone
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GenScript Custom all cDNA clones Services for MEG3
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Cell Line
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Search LifeMap BioReagents cell lines for MEG3

In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEG3

Animal Models:
     Mouse knock-outs for MEG3: Meg3tm1Itl Meg3tm1Kono
     8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Meg3):
 cellular  embryogenesis  growth/size  homeostasis/metabolism  liver/biliary system 
 mortality/aging  muscle  respiratory system 

MEG3 for phenotypes           About GeneDecksing


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MEG3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MEG3
Search CenterWatch for drugs/clinical trials and news about MEG3 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for MEG3:

Maternally expressed 3 (non-protein coding)
Hs.654863  [show with all ESTs]
Unigene Representative Sequence: NR_046473
18/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
ENST00000556407(lincRNA) ENST00000429159(lincRNA)(uc010txe.2 uc010txd.2 uc010avz.2 uc010txf.2 uc001yib.3)
ENST00000520714(lincRNA) ENST00000522771(lincRNA) ENST00000424076(lincRNA)(uc021sbw.1) ENST00000423456(lincRNA)(uc001yhy.3)
ENST00000521404(lincRNA) ENST00000556736(lincRNA)(uc001yhz.3 uc010txg.2) ENST00000451743(lincRNA)(uc001yhw.3 uc010txb.2)
ENST00000398518(lincRNA) ENST00000554639(lincRNA)(uc010txc.2 uc001yie.3) ENST00000452120(lincRNA)
ENST00000519709(lincRNA)(uc010txh.2) ENST00000412736(lincRNA)(uc001yic.3) ENST00000455286(lincRNA)
ENST00000523671(lincRNA) ENST00000452514(lincRNA) ENST00000398474(lincRNA)(uc021sbx.1 uc001yid.2)


miRNA
Products:
     
Browse 3'-UTR reporter clones for miRNA target validation
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEG3
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MEG3
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
Browse OriGene 29mer shRNA kits
Browse OriGene siRNA
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEG3
Clone
Products:
     
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for MEG3
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEG3
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MEG3 
Primer
Products:
    
Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MEG3
  Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEG3
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEG3

Additional cDNA sequence: 

AB032607.1 AF052114.1 AK092707.1 AK098378.1 AK124580.1 AY314975.1 BC036602.1 BC036882.1 
BC062783.1 BC092509.1 BX161432.1 BX161452.1 BX247998.1 BX248012.1 GQ183494.1 GQ183495.1 
GQ183496.1 GQ183497.1 GQ183498.1 GQ183499.1 GQ183500.1 GQ183501.1 GQ183502.1 GQ183503.1 
NR_002766.2 NR_003530.2 NR_003531.3 NR_033358.1 NR_033359.1 NR_033360.1 NR_046464.1 NR_046465.2 
NR_046466.1 NR_046467.1 NR_046468.2 NR_046469.1 NR_046470.2 NR_046471.1 NR_046472.1 NR_046473.1 

24/85 DOTS entries (see all 85):

DT.100892831  DT.97812871  DT.95196617  DT.455127  DT.95103845  DT.100892857  DT.95207522  DT.455076 
DT.100803337  DT.97764803  DT.100771275  DT.100045101  DT.100833667  DT.95196716  DT.91961664  DT.95366306 
DT.101985491  DT.95196719  DT.100045099  DT.307796  DT.97816231  DT.100892843  DT.100837676  DT.100892870 

976 AceView cDNA sequences (see top 24):

BI913162 BM510493 AA297065 BE669505 BU784805 CR612108 BQ716711 AA351773 
CR603291 CR615599 AL035808 BQ270798 AI018638 BX462855 BF057815 CR597219 
BU790470 AF052114 CR608797 BX438953 BX371175 BQ270557 CR609941 AI870856 
CR615598 BU786085 BM507210 BF059280 BU787606 BI915088 BX099173 CR610233 
BU579722 CR608449 CR620703 AA968737 BM875450 CR617022 AI874325 CR606010 
AJ413186 BI837843 BQ416812 BX399541 H91065 AI214764 CB069647 AI268349 
BU790174 R98221 AI967972 CR603886 BE552022 BQ548989 AI125171 CD722544 
BX432727 BX444313 BU783773 BQ548879 BM930045 BE550258 BX161452 CB216396 
AI342797 BQ185478 BM315103 BU947295 BU069827 BX449881 AA587544 BE222690 
CR624712 BQ183148 CR620657 CF454067 Z40298 BM721386 AI424534 CR618544 
AI801328 BX356998 CR592849 AI493259 AW237127 BX462852 BX398082 CR620241 
BX445327 AI368233 CR623957 BM876329 AA904190 AI138899 BM512260 CB068049 
AA722764 CR621793 BQ717638 BQ718013 AI299753 AI133545 AJ413187 AA319096 
AA779239 BX460093 BX092514 AA987892 BM509444 BE503216 AI621180 BU751924 
CR591736 CD513101 AI802182 BX398582 CR610066 CR611497 CR613369 BQ549685 
CR609760 CR614788 CA772548 BM511324 BU075693 BU783107 AA025909 CR607907 
BU069931 BU579625 BX358341 BU788946 BQ447322 BX248012 AY314975 AA579349 
BM313904 BE155780 CK904952 CR620087 BM510363 CR626265 BM507054 BX353476 
AL042643 H93453 CR612008 BU075874 BM887958 AI199915 AA987697 BQ130070 
BX326145 BM506704 BX952525 BM722506 CR602474 CR596535 AA625740 AI352365 
BX247998 BU687787 BX440738 AW236979 BX422356 AW964176 AI637819 AW593813 
BX440609 BX441531 BM271960 AK124580 BM055113 BQ181140 AA722579 BX397338 
BI439601 AL133820 CR603748 AW515017 BX161432 AW237013 AI401572 BX422438 
AI302250 BE551364 BM805094 CR591136 AW161496 AI332300 CR598389 AW896035 
CN483371 AF119863 BU070270 BU580862 AI024488 BX406370 AI366496 CR593817 
AA894424 AW163035 AW316731 BF056354 BF109085 AI189406 BQ023646 BE500971 
AI223081 AK098378 BU952631 AI240743 BX422267 BQ417116 CB070135 AW014491 
CA865965 BU782673 BQ129987 BX347225 BE045535 BM565480 BX448226 BM142609 
BX449784 BE671478 AL039025 BX326323 AA918364 C21164 BX332484 BI552705 
BX396701 R12264 BI766509 BU580404 BX411177 BQ477456 AI292216 AL042644 
BF311869 BX346167 BQ549202 BX335796 AA722062 CF541159 BF110815 BG716521 
BX442877 BX354606 BM903574 AI681544 AK057522 BU784045 AW089342 AW003239 
BQ575886 BX326047 BU678061 AA610121 BQ270591 BU070170 BX449785 AI690267 
BM804755 AI459255 H73440 H67586 BF433098 AV709428 BI544285 BU789202 
BM263035 BM920614 AW090068 BF944910 AW004002 AV729489 BM857657 BX408790 
BX429896 AI657197 CB268967 H48532 BQ638092 BX403373 AK055725 BQ269256 
BM055413 AW817306 BX408697 BX408189 AV706943 BQ267620 BM919525 BI524001 
BX367552 AA297821 BE348824 AI277747 BF115526 BM699430 BG703541 AI205863 
AI962167 BM716949 AW956533 BM055212 BX471315 AW157066 AA329370 AI969268 
BX346166 BE218575 BM311016 BG619996 AI494251 BG700039 AL708109 AV691186 
AA326520 AI632499 AV660040 BG009566 BU786542 BX459919 BI838477 AI374672 
BQ787527 AV693188 AA442765 BX407747 BE811119 BQ267994 BM313642 BE673794 
R97241 AA297227 BC051294 AI652156 AI950273 BQ575489 AI061167 BQ129947 
BQ719859 BM906142 AW148855 AA343112 BU950864 AA298957 BX407662 AW138857 
AV689832 AV708377 AW590055 BU727542 BC036882 AA350087 AK092504 BM679161 
AI248895 CA943793 AK127864 AI634109 W73830 AI038726 BE220754 BX346951 
BX418977 BF435811 AV727351 AI188681 BX405678 BQ581661 N55284 Z44363 
BI600997 BU070059 AL599338 CD243229 AI697564 AW207761 AV701976 H71131 
CB154926 BX325060 BQ016490 BX451950 BX325123 BX408226 BU738529 BM679015 
AA678332 BX463384 BU579968 BQ477876 BX426730 AV685380 BU070003 H91969 
BF195282 BQ130198 BX385939 AI266648 AA483847 N90143 CD238875 BX643408 
BX429998 AI003540 AA351535 N72524 BQ716544 AA777328 BU579805 BX459667 
BM875701 AV709310 BE674246 AV684463 BX368151 AI146279 BX479281 BF061825 
BQ581991 BX422612 BM929634 BX408784 AA319170 BX336001 H62465 AA701267 
BG619988 BU782628 CA771714 BX422168 BU071298 AK123878 AA582558 BE262969 
AW590523 BI770703 AA342665 BX325059 BE811124 CD251795 AA368167 BE049555 
AI346588 BX407693 BQ721264 BI545362 CB146088 BM919491 CB156762 BC062783 
BX472960 AI370446 BM512019 AL603210 BQ187826 AB032607 CN479847 BX111451 
AL042942 AA788892 BE811117 BM544142 BM920327 BX450006 BG654831 BX429337 
AI968392 BX509220 BX408219 AL712621 AI091315 BF757582 BQ581130 BM504444 
BX427898 BF433565 AU252496 BI457289 BC023543 BG010030 AA429727 CA943189 
AA327773 CB241663 BM683586 BQ771670 BU071521 AI672054 AA429656 AI797089 
H93454 CA391561 AA297100 BX478515 BE465010 BX448225 BU681765 BQ268259 
BX356972 BX443856 BX428872 BM509198 BX463221 BM893616 BX429869 AI133465 
BX444450 BG149462 CA949980 BX429093 AI342082 T50097 AK126659 BX330409 
BX453064 BM966850 BM722286 BX367139 AI453538 BX498325 CA866255 BX427197 
BE155782 BU783619 AA378850 CD300268 BX444351 BM508181 BM054960 BI438508 
AI174720 BM722672 AI638278 R44918 BF056041 AA984335 BX353475 BU681590 
BX388604 AK092707 CN481802 AV692560 BQ774315 BI913368 BX405426 BE671399 
BI553463 AA348506 BU787882 AW897540 BQ549308 BG620698 BI160994 AI337141 
AW771691 CB243349 BQ706198 BQ548748 BU069661 AA564146 AA297678 T08737 
BX346811 BF994607 W17372 AI014279 AA034073 R91574 BX478899 AL035801 
BM507366 BX336000 BI050706 BX450687 AV688028 AI654556 H71305 AV685582 
AV723467 AV688678 BX347279 AA864431 BX412723 AA319866 AW081786 BX354605 
AW956454 H59610 AA608939 BI603062 CK004916 AA988898 N54358 N53565 
AA318543 BU783666 AA002103 BG015185 H89924 BE699627 AA628340 H70901 
AA054858 BE699599 AW156990 AA297093 AA319377 BF882608 BM544172 BV202012 
AW892793 H73768 AV753036 BU075784 AA972349 CB989014 AI968579 BG896653 
BX374820 BM565623 BF446820 BQ723199 AW079014 BE671107 AA378929 BU069445 
BF997615 BF437913 AA349200 BU947650 AI367110 BG194761 AI133721 BI524541 
AA296981 BX444221 AA377762 R89121 AI638405 BM314810 R11658 CB154821 
CA393017 BU075590 BE672598 R44788 BX429130 BE930635 R94675 BI712978 
BG014281 BQ270834 BQ067825 BF942873 AA587566 AV695947 N51408 AA620289 
H59227 BI458022 AW957355 BX352101 AA948316 BU101708 AA984278 BI049309 
AA297021 AI143174 BI032505 AL706407 BG820393 AW170102 N55357 AI867847 
AI651103 AA777077 BX432728 BX407756 H40310 AA318859 AV702612 AV684461 
AI143719 W85946 BV204924 W67892 AA326681 T98871 AA699845 CA773340 
BI838293 BG719704 BG434362 AI457219 N78818 BF925433 BM687248 BQ130320 
BX429954 H91361 AW196226 BE771644 BI916294 AA319435 BF956762 D81154 
W25097 BX388426 W88477 H82658 AI298157 H49428 H54457 AA378645 
BM809044 BG999764 N92066 H70899 AV706475 W69081 AW872813 R92223 
R42971 W73864 BQ285898 H51546 W93422 BQ368536 AA319172 BG011031 
BM264590 BG104698 BI055388 BQ130786 AW371545 BX408696 AA329153 BG009564 
BF849848 C17126 H91329 BF314353 BU950166 BF093598 BF854849 AV750210 
AA029032 AW197392 T50040 BM687087 H69465 BX423733 BI767968 BI052387 
BX471020 BG570819 BG014716 W88715 AU252497 BF772049 H70689 BI818211 
BG005205 BQ370737 AW958338 BQ181864 BG004177 AI689792 AI273614 AA927501 
AW016235 AW263368 AI000703 BQ669975 AV748482 BM876591 AW961532 BU781965 
D61523 BF994597 BM504225 H82401 R87223 AV694165 BX451951 BU950452 
BQ718723 AA002104 R94676 H45995 H79052 BE383106 BF987174 H59650 
H48704 H71130 AV749927 W88716 R97987 AA318761 BX367665 AV704361 
BI032985 AV693628 BF854850 BM807525 W38427 H62151 W95825 BQ370677 
AV753072 BF993484 BF768651 BG013560 H78029 BG013548 AV748249 BF998500 
AA328911 BU579864 AA699757 AA927999 BG009547 AA029246 W95826 BE930972 
AA317250 BG011039 N76324 BI058848 R97197 BU101707 BE046799 H59415 
AV748809 BX336043 BU071278 BX500153 AV699879 BQ130239 N57752 T90649 
H54194 H62541 AV704581 BF950694 BQ776936 BF362115 W80682 AA969743 
AV751283 T83176 AA910954 BF961363 H91435 BX460799 BU783352 W85841 
AV745845 AI207892 H73009 BG013257 BG003219 R84442 BX336044 BG008531 
AV748976 BF956396 N77363 AV722591 BQ370138 BF741576 BF843192 BG009540 
R97198 BM509370 AV748693 BM808176 AW384297 BI049934 N76892 BX443802 
BF110644 BI050272 H67308 BF994602 AV748261 BM857829 AA676792 BX450283 
H58263 H87083 N59719 R16781 AA298914 AW897544 BI051553 BI054758 
BI055552 H49427 AV747610 CK005350 BX429449 BQ343008 AW582515 H58896 
N66923 BE466794 R99460 AA025506 R01986 BF364954 BX422422 BX484792 
H62609 AW770726 AV690806 R00535 H71307 CK004478 BI050384 AW817314 
R91627 H69871 AW898161 AW134636 R16481 BX430003 R87222 AV705420 
AV749581 R99461 H68518 BG003215 N56264 AA432355 BX405744 R18076 
BM894185 H58895 AW954931 AV748189 T93776 H58998 R97242 BQ370730 
AV752977 BI050157 BF996475 AA090535 H74152 BF996505 R28916 BE767017 
BF989854 H51547 BF350717 H74199 R91818 BG012902 BE155774 BX459796 
BF997618 BG013547 BF364941 T93821 BF997377 W07248 R00637 BQ366470 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for MEG3:none

MEG3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGATTGTCAT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image

MEG3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
9 LifeMap In Vivo Development Anatomical Compartments/Cells 
Tissue Anatomical Compartment CellCategory (developmental path)
EyeInner Nuclear LayerMature Rod Bipolar CellsBipolar, Retina
HeartCardiac CrescentCardiac Crescent CellsMyocardium
TestisSeminiferous TubulesSertoli cellsTestis
BoneMandibular CondyleBone
BoneMandibular ProcessBone
BoneZeugopod Epiphyseal EndBone
KidneyMetanephrosKidney
KidneyRenal Collecting Duct SystemKidney
Reproductive SystemMesonephrosReproductive System
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

Genevestigator expression for MEG3

SOURCE GeneReport for Unigene cluster: Hs.654863
    SABiosciences Custom PCR Arrays for MEG3
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for MEG3 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Meg35 maternally expressed 3   --   12 (60.25 cM) 109541001 


ENSEMBL Gene Tree for MEG3 (if available)
TreeFam Gene Tree for MEG3 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/665 NCBI SNPs in MEG3 are shown (see all 665    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs733475901,2
C,--81471375(+) CGTCAA/GCTCAT 16 -- us2k12Minor allele frequency- G:0.04WA 120
rs793936411,2
C,--81472215(+) NNNNTC/AACCTG 16 -- us2k14Minor allele frequency- A:0.05CSA WA NA 241
rs777648931,2
--81473106(+) GCACCG/CGCGAC 16 -- us2k11Minor allele frequency- C:0.50CSA 2
rs128824971,2
H--81473297(+) CCCTTC/ATGCGC 16 -- us2k14Minor allele frequency- A:0.00NS EA 418
rs455460401,2
--81473434(+) TCACCC/TGGTGA 16 -- nc-transcript-variant1Minor allele frequency- T:0.01WA 118
rs726987621,2
C,F,--81474883(+) TGTGGC/AGAAGG 16 -- int11Minor allele frequency- A:0.04NA 120
rs769430631,2
F,--81475083(+) TGGATT/CGACGA 16 -- int11Minor allele frequency- C:0.09WA 118
rs796120001,2
C,--81475623(+) CCTCCC/GCCTCC 16 -- int12Minor allele frequency- G:0.09WA 120
rs115400271,2
H--81476383(+) TAAAGA/TCTTAA 16 -- nc-transcript-variant4Minor allele frequency- T:0.00NS EA 404
rs454702941,2
--81476530(+) GGGGGC/TGTCAG 16 -- nc-transcript-variant0--------

HapMap Linkage Disequilibrium report for MEG3 (101245747 - 101327368 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MEG3
     1 CNV: 8776

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MEG3 for disorders           About GeneDecksing

OMIM gene information: 605636    OMIM disorders: --

11 diseases for MEG3:    About MalaCards
maternal uniparental disomy, chromosome 14    acute myeloid leukemia    pituitary adenoma    myeloid leukemia
pituitary tumor    myelodysplastic syndrome    seminoma    adenoma
hepatocellular cancer    meningioma    leukemia

1 disease from the University of Copenhagen DISEASES database for MEG3:
Seminoma

Export disorders for MEG3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MEG3 gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with MEG3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. (PubMed id 10759892)1, 2, 3, 9 Miyoshi N.... Ishino F. (2000)
  2. Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. (PubMed id 15644399)1, 9 Zhao J....Klibanski A. (2005)
  3. Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes. (PubMed id 18176563)1, 9 Kagami M.... Ogata T. (2008)
  4. Expression of cell growth negative regulators MEG3 and GADD45g is lost in most sporadic human pituitary adenomas. (PubMed id 21850407)1 Mezzomo L.C....Kohek M.B. (2012)
  5. MEG3 noncoding RNA: a tumor suppressor. (PubMed id 22393162)1 Zhou Y....Klibanski A. (2012)
  6. Overexpression of the long non-coding RNA MEG3 impairs in vitro glioma cell proliferation. (PubMed id 22234798)1 Wang P....Sun P. (2012)
  7. microRNA-29 can regulate expression of the long non-c oding RNA gene MEG3 in hepatocellular cancer. (PubMed id 21625215)1 Braconi C....Patel T. (2011)
  8. Silencing of the imprinted DLK1-MEG3 locus in human c linically nonfunctioning pituitary adenomas. (PubMed id 21871428)1 Cheunsuchon P....Klibanski A. (2011)
  9. Maternally expressed gene 3, an imprinted noncoding R NA gene, is associated with meningioma pathogenesis and progression. (PubMed id 20179190)1 Zhang X....Klibanski A. (2010)
  10. The IG-DMR and the MEG3-DMR at human chromosome 14q32 .2: hierarchical interaction and distinct functional properties as imprinting c ontrol centers. (PubMed id 20585555)1 Kagami M....Ogata T. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 55384 HGNC: 14575 AceView: MEG3 Ensembl:ENSG00000214548 euGenes: HUgn55384
ECgene: MEG3 H-InvDB: MEG3

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MEG3 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MEG3 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MEG3 gene:
Search GeneIP for patents involving MEG3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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