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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MEG3 Gene

RNA gene   GIFtS: 34
GCID: GC14P101245

Maternally Expressed 3 (Non-Protein Coding)

(Previous name: maternally expressed 3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 3

Aliases
Maternally Expressed 3 (Non-Protein Coding)1 2     LINC000232
GTL22 5     NCRNA000232
Long Intergenic Non-Protein Coding RNA 231     PRO05182
Maternally Expressed 31     PRO21602
Non-Protein Coding RNA 231     prebp12
FP5042     

External Ids:    HGNC: 145751   Entrez Gene: 553842   Ensembl: ENSG000002145487   OMIM: 6056365   UniProtKB: Q9UI563   

Export aliases for MEG3 gene to outside databases

Previous GC identifers: GC14P098688 GC14P095112 GC14P099282 GC14P099287 GC14P099285 GC14P100363 GC14P100364 GC14P100368 GC14P100371 GC14P100373 GC14P101292 GC14P081473


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MEG3 Gene:
This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been
transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many
normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits
tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene
expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is
a lncRNA tumor suppressor. (provided by RefSeq, Mar 2012)

GeneCards Summary for MEG3 Gene: 
MEG3 (maternally expressed 3 (non-protein coding)) is an RNA gene, and is affiliated with the lncRNA class. Diseases associated with MEG3 include maternal uniparental disomy, chromosome 14, and uniparental disomy, paternal, chromosome 14.

Gene Wiki entry for MEG3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MEG3 gene promoter:
         Max1   CREB   deltaCREB   Olf-1   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MEG3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.2

MEG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEG3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P101245:  view genomic region     (about GC identifiers)

Start:
101,245,747 bp from pter      End:
101,327,368 bp from pter
Size:
81,622 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: YYY4_HUMAN, Q9UI56 (See protein sequence)
Recommended Name: Very putative protein from MEG3 locus  
Size: 68 amino acids; 7791 Da
Caution: Product of a dubious gene prediction. There is no evidence of expression of this protein. The MEG3
(Maternally Expressed) gene probably codes for a RNA

Explore the universe of human proteins at neXtProt for MEG3: NX_Q9UI56

MEG3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

Human Recombinant Protein Products for MEG3: 

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Browse OriGene Protein Over-expression Lysates
OriGene Custom MassSpec 
OriGene Custom Protein Services for MEG3
GenScript Custom Purified and Recombinant Proteins Services for MEG3
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 


MEG3 Antibody Products: 
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Search for Antibodies for MEG3 at Abcam
Browse Antibodies at Cloud-Clone Corp. 
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Search LSBio for Antibodies for MEG3 

Assay Products for MEG3: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for MEG3
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for MEG3
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
LNCRNA: Long non-coding RNAs

ProtoNet protein and cluster: Q9UI56


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Meg3):
 cellular  embryogenesis  growth/size  homeostasis/metabolism  liver/biliary system 
 mortality/aging  muscle  respiratory system 

MEG3 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for MEG3: Meg3tm1Itl Meg3tm1Kono

   inGenious Targeting Laboratory - Custom generated mouse model solutions for MEG3 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MEG3

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MEG3 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MEG3 

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEG3
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MEG3
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for MEG3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEG3

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for MEG3
Sirion Biotech Customized adenovirus for overexpression of MEG3

Clone
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Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for MEG3
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEG3
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MEG3
Sirion Biotech Customized lentivirus for stable overexpression of MEG3 
                     Customized lentivirus expression plasmids for stable overexpression of MEG3 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for MEG3
Search LifeMap BioReagents cell lines for MEG3
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEG3


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MEG3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MEG3 (YYY4)

Search CenterWatch for drugs/clinical trials and news about MEG3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for MEG3:

Maternally expressed 3 (non-protein coding)
Hs.654863  [show with all ESTs]
Unigene Representative Sequence: NR_046473
18/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
ENST00000556407(lincRNA) ENST00000429159(lincRNA)(uc010txe.2 uc010txd.2 uc010avz.2 uc010txf.2 uc001yib.3)
ENST00000520714(lincRNA) ENST00000522771(lincRNA) ENST00000424076(lincRNA)(uc021sbw.1) ENST00000423456(lincRNA)(uc001yhy.3)
ENST00000521404(lincRNA) ENST00000556736(lincRNA)(uc001yhz.3 uc010txg.2) ENST00000451743(lincRNA)(uc001yhw.3 uc010txb.2)
ENST00000398518(lincRNA) ENST00000554639(lincRNA)(uc010txc.2 uc001yie.3) ENST00000452120(lincRNA)
ENST00000519709(lincRNA)(uc010txh.2) ENST00000412736(lincRNA)(uc001yic.3) ENST00000455286(lincRNA)
ENST00000523671(lincRNA) ENST00000452514(lincRNA) ENST00000398474(lincRNA)(uc021sbx.1 uc001yid.2)

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEG3
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MEG3
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for MEG3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEG3
Clone
Products:
     
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for MEG3
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEG3
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MEG3
Sirion Biotech Customized lentivirus for stable overexpression of MEG3 
                     Customized lentivirus expression plasmids for stable overexpression of MEG3 
Primer
Products:
    
Browse OriGene qPCR
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MEG3
  Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEG3
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEG3

Additional mRNA sequence: 

AB032607.1 AF052114.1 AK092707.1 AK098378.1 AK124580.1 AY314975.1 BC036602.1 BC036882.1 
BC062783.1 BC092509.1 BX161432.1 BX161452.1 BX247998.1 BX248012.1 GQ183494.1 GQ183495.1 
GQ183496.1 GQ183497.1 GQ183498.1 GQ183499.1 GQ183500.1 GQ183501.1 GQ183502.1 GQ183503.1 
NR_002766.2 NR_003530.2 NR_003531.3 NR_033358.1 NR_033359.1 NR_033360.1 NR_046464.1 NR_046465.2 
NR_046466.1 NR_046467.1 NR_046468.2 NR_046469.1 NR_046470.2 NR_046471.1 NR_046472.1 NR_046473.1 

24/85 DOTS entries (see all 85):

DT.100892831  DT.97812871  DT.95196617  DT.455127  DT.95103845  DT.100892857  DT.95207522  DT.455076 
DT.100803337  DT.97764803  DT.100771275  DT.100045101  DT.100833667  DT.95196716  DT.91961664  DT.95366306 
DT.101985491  DT.95196719  DT.100045099  DT.307796  DT.97816231  DT.100892843  DT.100837676  DT.100892870 

976 AceView cDNA sequences (see top 24):

BE222690 CR609941 BF059280 BQ270557 BX371175 CD722544 BX449881 CR610233 
AF052114 AI342797 BX440609 AI637819 AW593813 BM271960 BX441531 AK124580 
BM055113 BQ181140 AA722579 BI439601 BX397338 BX161432 AW515017 CR603748 
AI401572 AW237013 AL133820 BX422438 AI302250 BE551364 CR591136 BM805094 
AW161496 AI332300 CR598389 CN483371 AF119863 AW896035 BX406370 AI366496 
BU070270 AI024488 BU580862 AW316731 AW163035 CR593817 AA894424 BF056354 
AI189406 BQ023646 BF109085 BE500971 AI223081 BQ548989 CR612108 BQ716711 
BE669505 BU784805 AL035808 CR624712 CR597219 AA297065 BX422267 AI125171 
AK098378 CR603886 BU790470 BU952631 AI240743 BF057815 CB070135 BX462855 
AI018638 BQ417116 AW014491 BU782673 BQ270798 AI870856 BM930045 BQ549685 
CR611497 CR613369 CR610066 CR609760 CR614788 BU069931 BM511324 CA772548 
AA025909 BU783107 BU075693 CR607907 BU579625 BX358341 BU788946 BM313904 
BQ447322 AY314975 BE155780 BX248012 AA579349 CR626265 CR620087 BM507054 
BM510363 CK904952 BX353476 AL042643 CR612008 H93453 BU075874 BM887958 
AI199915 AA987697 BQ130070 BM506704 BX326145 BM722506 CR602474 BX952525 
CR596535 AA625740 BX247998 AI352365 BU687787 AW236979 BX440738 BX422356 
AW964176 BM315103 CR603291 AA351773 CR615599 BI913162 BX432727 BU069827 
CB216396 BX444313 BU783773 BE550258 BX161452 AI268349 BQ185478 CB069647 
R98221 BU790174 AJ413186 CR606010 H91065 BQ416812 AI874325 BX399541 
AI214764 BQ129987 AI967972 CA865965 CR608449 BU579722 AA968737 BM875450 
CR617022 CR620703 BI837843 BM510493 BE552022 BX347225 BQ183148 CR620657 
CF454067 Z40298 AI424534 BM721386 BX356998 AW237127 AI801328 AI493259 
BX398082 CR592849 CR618544 BX462852 BX445327 CR620241 AI368233 AA904190 
CR623957 BM512260 CB068049 BM876329 CR621793 AI138899 BQ717638 BQ718013 
AA722764 AA319096 AA779239 AI133545 AI299753 AJ413187 BX460093 AA987892 
BX092514 BE503216 BM509444 AI621180 BU751924 CR591736 CD513101 BX398582 
AI802182 AA587544 BQ548879 BI915088 CR615598 BM507210 BU786085 CR608797 
BU787606 BX438953 BU947295 BX099173 AI681544 AI690267 AI374672 BE673794 
AW089342 AW003239 BX326047 AV709428 AK057522 BM804755 BX459919 AW956533 
AI494251 BU070170 BX449785 AI459255 BX354606 BU678061 BF433565 BM504444 
AU252496 BX427898 BG010030 AA429727 CA943189 BC023543 CB241663 BI457289 
BQ771670 AI672054 BM683586 AA327773 BU071521 AA297100 BX478515 AA429656 
H93454 CA391561 AI797089 BE465010 BU681765 BQ268259 BX356972 BX448225 
BX443856 BX428872 BX463221 BM509198 BM893616 BX444450 BX429869 BG149462 
BX429093 CA949980 AI133465 AI342082 BM722286 AK126659 T50097 BX453064 
BX330409 BE155782 BX367139 AI453538 BM966850 BX427197 CA866255 BX498325 
BX444351 CD300268 BU783619 AA378850 BM508181 BM054960 BI438508 BM722672 
AI638278 AI174720 R44918 BF056041 AK092707 AA984335 BX388604 BX353475 
CN481802 BI913368 BU681590 BQ774315 AV692560 AA918364 BM565480 BX448226 
C21164 BE348824 BF311869 BX367552 BX346167 BI524001 BX326323 BQ267994 
BE811119 AA297821 AA348506 BI766509 AL042644 BI553463 AI292216 AW897540 
BU787882 BU580404 AI277747 BF115526 BX411177 BE671399 BX405426 BQ477456 
R12264 BX442877 BM716949 BF110815 BX335796 BQ270591 BG700039 AA610121 
BU738529 BX463384 AA678332 BX426730 BM679015 BQ477876 BU579968 AV685380 
BU070003 BF195282 BQ130198 H91969 AI266648 BX385939 N90143 BX643408 
CD238875 AA483847 AI003540 AA351535 BX429998 N72524 BQ716544 BX459667 
AV684463 AV709310 BU579805 AA777328 BX368151 BE674246 BM875701 AI146279 
BX479281 BX422612 BX408784 BQ581991 BF061825 BM929634 AA701267 AA319170 
BX336001 H62465 BG619988 AK123878 AA582558 AW590523 BX422168 CA771714 
BE262969 BU071298 BU782628 BX325059 AA342665 CD251795 BE811124 BI770703 
AA368167 BE049555 BX407693 AI346588 BQ721264 CB146088 CB156762 BI545362 
BM919491 BQ187826 BC062783 AI370446 BX472960 AL042942 BM512019 AL603210 
BG654831 CN479847 AA788892 BM920327 AB032607 AI968392 BX450006 BM544142 
BX111451 BX509220 BE811117 BX429337 BF757582 BX408219 AI091315 AL712621 
BQ581130 BM313642 BI838477 BE045535 BX407747 AI962167 AA326520 AI632499 
BQ787527 BI552705 AA442765 BG009566 BU786542 BX332484 BM142609 BG703541 
AV660040 AI205863 AV693188 AL708109 BG619996 BX471315 BM055212 BM311016 
BE218575 AA329370 AW157066 AI969268 BX346166 BQ267620 BX449784 AK055725 
BQ269256 AW817306 BI160994 AV706943 AI337141 BX403373 BX396701 AI657197 
BX408790 BQ638092 BX429896 CB268967 H48532 AV691186 AW004002 BQ549308 
BU789202 BI544285 AW090068 BM263035 BM920614 BQ706198 BF944910 AV729489 
BM857657 AL039025 BG620698 CB243349 BX408697 BX408189 BE671478 BM055413 
AW771691 BM919525 BQ549202 R97241 AI652156 AI061167 AA297227 BC051294 
AI950273 BQ719859 BQ575489 BQ129947 BM906142 AW148855 AA298957 AA343112 
AV689832 AW138857 AV708377 BU950864 BX407662 BU727542 AW590055 BM679161 
CA943793 AA350087 AI248895 AK092504 AI634109 BC036882 BX418977 BE220754 
AI038726 W73830 BX346951 AK127864 AV727351 BF435811 AI188681 BX405678 
BI600997 Z44363 AI697564 N55284 BQ581661 BU070059 CD243229 AW207761 
AL599338 H71131 AV701976 BX325060 BQ016490 CB154926 BX451950 BX325123 
BX408226 BQ575886 CF541159 BM903574 H73440 BG716521 BU784045 H67586 
BF433098 BM699430 AA722062 BX478899 BM507366 BU783666 AI654556 N53565 
AV685582 H71305 AA777077 BX432728 AA318859 AV702612 AV684461 AI143719 
W85946 BV204924 W67892 AA326681 T98871 AA699845 CA773340 BI838293 
BG719704 AI457219 BG434362 N78818 BF925433 BX346811 BQ548748 AA297678 
AA564146 R91574 T08737 AA988898 CK004916 AA034073 AI014279 BF994607 
BG194761 AI133721 BI524541 AA296981 AI638405 CB154821 BX444221 BM314810 
AA377762 R11658 BU075590 R89121 CA393017 BE672598 R94675 BX429130 
R44788 BE930635 BI712978 BG014281 BQ270834 BF942873 AV695947 BQ067825 
AA587566 N51408 BI458022 AA620289 H59227 BX352101 BU101708 AW957355 
AA948316 AA297021 AI143174 BI049309 AA984278 BI032505 AL706407 AW170102 
BG820393 AI651103 N55357 AI867847 BX407756 H40310 AV688028 BU069661 
BG015185 BE699627 AA628340 N54358 H70901 H59610 AA608939 BI603062 
AW956454 AA319866 BX412723 BX354605 AW081786 BQ130320 BM687248 AV688678 
AV723467 AA864431 BX347279 BX429954 H91361 AA054858 AW156990 BE699599 
AA319377 BF882608 BM544172 AA297093 BV202012 AW892793 H73768 BU075784 
AI968579 CB989014 AV753036 BG896653 AA972349 BX374820 BM565623 BF446820 
AW079014 BQ723199 AA378929 BF997615 BU069445 BE671107 BF437913 BU947650 
AA349200 AI367110 AL035801 BX450687 BX336000 BI050706 H89924 AA318543 
AA002103 W17372 W93422 R92223 AI298157 AW263368 AI000703 BM876591 
BQ669975 AV748482 AW961532 BU781965 BF994597 D61523 BM504225 H82401 
R87223 AV694165 BX451951 BQ718723 AA002104 BU950452 R94676 BF956762 
AA319435 H45995 H79052 BQ285898 H51546 BE383106 BF987174 W88477 
D81154 W69081 BF854849 AV750210 AA029032 AW197392 T50040 BM687087 
H69465 BX423733 BI767968 BI052387 BG570819 W88715 BG014716 BX471020 
AU252497 H70689 BF772049 BI818211 BG005205 AW958338 BQ370737 BQ181864 
BG004177 AI689792 AW016235 AI273614 AA927501 W25097 AW196226 W73864 
AW872813 AV706475 H70899 H59650 AA378645 BG999764 BE771644 BM809044 
N92066 BI916294 R42971 BQ368536 AA319172 BG011031 BM264590 BG104698 
BI055388 BQ130786 AW371545 BX408696 AA329153 BG009564 C17126 H91329 
BF849848 BF314353 BU950166 BF093598 H49428 BX388426 H54457 H82658 
H71130 BX367665 AA318761 W88716 BF362115 W80682 BQ776936 AA969743 
AV751283 T83176 AA910954 BF961363 H91435 BX460799 W85841 BU783352 
AV745845 AI207892 H73009 BG013257 R84442 BG003219 BX336044 AV748976 
BG008531 AV722591 BF993484 N77363 BF956396 BQ370138 H48704 H62151 
AV749927 BG011039 N76324 BI058848 R97197 BU101707 BE046799 H59415 
BX336043 AV748809 BX500153 BU071278 N57752 AV699879 BQ130239 T90649 
H54194 H62541 AV704581 BF950694 AV753072 BQ370677 BF768651 BF741576 
BM807525 BF843192 BF854850 AV693628 AV704361 BI032985 BG009540 W38427 
BG013560 BG013548 BF998500 H78029 AA328911 AV748249 BU579864 AA699757 
AA927999 AA029246 BG009547 AA317250 BE930972 W95826 R97987 W95825 
H58263 AA676792 BI049934 R01986 BF364954 BX422422 BX484792 H62609 
AW770726 R00535 AV690806 H71307 AV748261 AV748693 R97198 AW384297 
N76892 BI055552 H49427 AV747610 CK005350 BX429449 BQ343008 AW582515 
H58896 N66923 BE466794 AA025506 R99460 BM509370 BM857829 BX450283 
H67308 BF994602 BI050272 BF110644 H87083 N59719 R16781 AA298914 
AW897544 BI051553 BI054758 BX443802 BM808176 AV748189 T93776 H58998 
R97242 BQ370730 AV752977 AW134636 AW898161 H69871 BX405744 AA432355 
R18076 BM894185 H58895 AW954931 R91627 BI050157 R87222 AV705420 
BX430003 AV749581 R99461 H68518 BG003215 N56264 CK004478 R16481 
AW817314 BI050384 BF996475 BF997618 BG013547 BF996505 BF364941 R91818 
BG012902 BE155774 BX459796 R28916 BF997377 T93821 H74152 BE767017 
BF989854 H51547 BF350717 H74199 AA090535 BQ366470 R00637 W07248 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for MEG3:none

MEG3 expression in normal human tissues (normalized intensities)      MEG3 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGATTGTCAT
MEG3 Expression
About this image


MEG3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/24 selected tissues (see all 24) fully expand
 
 Kidney (Urinary System)    fully expand to see all 4 entries
         Metanephros
         visceral organ/metanephros/nephrogenic zone   
 
 Lower Urinary Tract (Urinary System)    fully expand to see all 4 entries
         visceral organ/urogenital sinus/primitive bladder   
 
 Bone (Muscoskeletal System)    fully expand to see all 3 entries
         Mandibular Process
 
 Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
         Wharton's jelly-derived stem cells
 
 Eye (Sensory Organs)    fully expand to see all 2 entries
         Mature Rod Bipolar Cells Inner Nuclear Layer
         Human Trabecular Meshwork Cells (HTMC)   

Genevestigator expression for MEG3

SOURCE GeneReport for Unigene cluster: Hs.654863
    SABiosciences Custom PCR Arrays for MEG3
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for MEG3 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Meg35 maternally expressed 3   --   12 (60.25 cM) 109541001 


ENSEMBL Gene Tree for MEG3 (if available)
TreeFam Gene Tree for MEG3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/776 SNPs in MEG3 are shown (see all 776)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs676749441,2
C--81487177(+) AAACT-/GT/TG 
        
GGTCA
16 -- int11NA 2
rs1390033171,2
C--81492625(+) TCCGC-/CCTCCTCC 16 -- int10--------
rs116279931,2
C,F,A,H--82281996(+) TCCCAC/ACTGAG 15 -- us2k116Minor allele frequency- A:0.36NS EA NA WA CSA 1053
rs733475901,2
C,F--82282027(+) CGTCAA/GCTCAT 16 -- us2k12Minor allele frequency- G:0.04WA 120
rs1919000481,2
--82282042(+) TTGTGA/GGGCTG 16 -- us2k10--------
rs1834513421,2
--82282103(+) GGGTGC/TGTGGC 16 -- us2k10--------
rs1866262341,2
C--82282181(+) GCGTGC/TCCCTC 16 -- us2k10--------
rs1913183721,2
--82282194(+) CTCTGC/TCCCCG 16 -- us2k10--------
rs1838131081,2
C--82282298(+) CTGTTC/TCCTAG 16 -- us2k10--------
rs1173052731,2
F--82282554(+) TCTATC/GTCCCC 16 -- us2k11Minor allele frequency- G:0.02NA 120

HapMap Linkage Disequilibrium report for MEG3 (101245747 - 101327368 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for MEG3:    About this table     
Variant IDTypeSubtypePubMed ID
nsv509549CNV Insertion20534489
dgv1982n71CNV Loss21882294
nsv902241CNV Loss21882294
nsv902240CNV Loss21882294
nsv902237CNV Loss21882294
nsv832876CNV Loss17160897
nsv470669CNV Loss18288195
nsv827055CNV Gain20364138
esv2751158CNV Gain17911159

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 605636    OMIM disorders: --

12 diseases for MEG3:    About MalaCards
maternal uniparental disomy, chromosome 14    uniparental disomy, paternal, chromosome 14    seminoma    pituitary tumors
pituitary adenoma    myelodysplastic syndromes    acute myeloid leukemia    meningioma
adenoma    type 1 diabetes    myeloid leukemia    leukemia

1 disease from the University of Copenhagen DISEASES database for MEG3:
Seminoma

MEG3 for disorders           About GeneDecksing

Genetic Association Database (GAD): MEG3

Export disorders for MEG3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MEG3 gene, integrated from 9 sources (see all 38):
(articles sorted by number of sources associating them with MEG3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. (PubMed id 10759892)1, 2, 3, 9 Miyoshi N.... Ishino F. (2000)
  2. Long non-coding RNA MEG3 inhibits the proliferation of cervical carcinoma cells through the induction of cell cycle arrest and apoptos is. (PubMed id 23790166)1, 3 Qin R....Guo F. (2013)
  3. The imprinted DLK1-MEG3 gene region on chromosome 14q 32.2 alters susceptibility to type 1 diabetes. (PubMed id 19966805)1, 4 Wallace C....Clayton D.G. (2010)
  4. Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. (PubMed id 15644399)1, 9 Zhao J....Klibanski A. (2005)
  5. Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes. (PubMed id 18176563)1, 9 Kagami M.... Ogata T. (2008)
  6. Methylation status of imprinted genes DLK1-GTL2, MEST (PEG1), ZAC (PLAGL1), and LINE-1 elements in spermatozoa of normozoospermic men, unlike H19 imprinting control regions, is not associated with idiopathic recurr ent spontaneous miscarriages. (PubMed id 23415968)1 Ankolkar M....Balasinor N.H. (2013)
  7. Downregulated MEG3 activates autophagy and increases c ell proliferation in bladder cancer. (PubMed id 23295831)1 Ying L....Qiu F. (2013)
  8. MEG3: a novel long noncoding potentially tumour-suppre ssing RNA in meningiomas. (PubMed id 23307326)1 Balik V....Hajduch M. (2013)
  9. Expression of cell growth negative regulators MEG3 and GADD45g is lost in most sporadic human pituitary adenomas. (PubMed id 21850407)1 Mezzomo L.C....Kohek M.B. (2012)
  10. MEG3 noncoding RNA: a tumor suppressor. (PubMed id 22393162)1 Zhou Y....Klibanski A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 55384 HGNC: 14575 AceView: MEG3 Ensembl:ENSG00000214548 euGenes: HUgn55384
ECgene: MEG3 H-InvDB: MEG3

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MEG3 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MEG3 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MEG3 gene:
Search GeneIP for patents involving MEG3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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