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MEG3 Gene

RNA gene   GIFtS: 35
GCID: GC14P101245

Maternally Expressed 3 (Non-Protein Coding)

(Previous name: maternally expressed 3)
  See MEG3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 6.4

Aliases
Maternally Expressed 3 (Non-Protein Coding)1 2     LINC000232
GTL22 5     NCRNA000232
Long Intergenic Non-Protein Coding RNA 231     PRO05182
Maternally Expressed 31     PRO21602
Non-Protein Coding RNA 231     prebp12
FP5042     

External Ids:    HGNC: 145751   Entrez Gene: 553842   Ensembl: ENSG000002145487   OMIM: 6056365   UniProtKB: Q9UI563   
ORGUL members:    fRNAdb10:FR395646 FR361442 FR306562 FR072345 FR223715      
NCBI13:BC036602 XR_000167 AY314975    
NONCODE14:n338494 n409198 n344478 n405606 n406131 see all 9    
RNAdb15:RNZ11975 ASO2088 LIT3318 LIT3321 RNZ11976 see all 8    

Export aliases for MEG3 gene to outside databases

Previous GC identifers: GC14P098688 GC14P095112 GC14P099282 GC14P099287 GC14P099285 GC14P100363 GC14P100364 GC14P100368 GC14P100371 GC14P100373 GC14P101292 GC14P081473


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MEG3 Gene:
This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been
transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many
normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits
tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene
expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is
a lncRNA tumor suppressor. (provided by RefSeq, Mar 2012)

GeneCards Summary for MEG3 Gene:
MEG3 (maternally expressed 3 (non-protein coding)) is an RNA gene, and is affiliated with the lncRNA class. Diseases associated with MEG3 include maternal uniparental disomy, chromosome 14, and uniparental disomy, paternal, chromosome 14.

Gene Wiki entry for MEG3 Gene

fRNAdb sequence ontologies for MEG3 - the ORGUL cluster for this gene includes several descriptions:
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.
antisense_RNA - Antisense RNA is RNA that is transcribed from the coding, rather than the template, strand of DNA. It is therefore complementary to mRNA.
mature_transcript - A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.

View fRNAdb secondary structures for MEG3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the MEG3 gene promoter:
         Max1   CREB   deltaCREB   Olf-1   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MEG3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.2

MEG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEG3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P101245:  view genomic region     (about GC identifiers)

Start:
101,245,747 bp from pter      End:
101,327,368 bp from pter
Size:
81,622 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: YYY4_HUMAN, Q9UI56 (See protein sequence)
Recommended Name: Very putative protein from MEG3 locus  
Size: 68 amino acids; 7791 Da
Caution: Product of a dubious gene prediction. There is no evidence of expression of this protein. The MEG3
(Maternally Expressed) gene probably codes for an RNA

Explore the universe of human proteins at neXtProt for MEG3: NX_Q9UI56

Explore proteomics data for MEG3 at MOPED


See MEG3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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Browse Proteins at Cloud-Clone Corp.

 
Search eBioscience for Proteins for MEG3 

 
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Search antibodies-online for peptides for MEG3

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Search antibodies-online for antibodies for MEG3 

MEG3 Assay Products:

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Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
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Search eBioscience for ELISAs for MEG3 
antibodies-online kits for MEG3 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
LNCRNA: Long non-coding RNAs

ProtoNet protein and cluster: Q9UI56


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     7 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Meg3):
 cellular  embryogenesis  growth/size/body  liver/biliary system  mortality/aging 
 muscle  respiratory system 

Find genes that share phenotypes with MEG3           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for MEG3: Meg3tm1Itl Meg3tm1Kono

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MEG3
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MEG3

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MEG3
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MEG3

miRNA
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Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for MEG3
Predesigned siRNA for gene silencing in human, mouse, rat MEG3

Gene Editing
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DNA2.0 Custom Protein Engineering Service for MEG3

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Addgene plasmids for MEG3 

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEG3

Flow Cytometry
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eBioscience FlowRNA Probe Sets ( VA6-13006) for MEG3 


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
mitochondrion2
cytosol1
extracellular1
peroxisome1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MEG3
Interactions:

    GeneGlobe Interaction Network for MEG3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MEG3 (YYY4)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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4 fRNAdb Secondary structures:


Unigene Cluster for MEG3:

Maternally expressed 3 (non-protein coding)
Hs.654863  [show with all ESTs]
Unigene Representative Sequence: NR_046473
Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
ENST00000556407(lincRNA) ENST00000429159(lincRNA)(uc010txe.2 uc010txd.2 uc010avz.2 uc010txf.2 uc001yib.3)
ENST00000520714(lincRNA) ENST00000522771(lincRNA) ENST00000424076(lincRNA)(uc021sbw.1) ENST00000423456(lincRNA)(uc001yhy.3)
ENST00000521404(lincRNA) ENST00000556736(lincRNA)(uc001yhz.3 uc010txg.2) ENST00000451743(lincRNA)(uc001yhw.3 uc010txb.2)
ENST00000398518(lincRNA) ENST00000554639(lincRNA)(uc010txc.2 uc001yie.3) ENST00000452120(lincRNA)
ENST00000519709(lincRNA)(uc010txh.2) ENST00000412736(lincRNA)(uc001yic.3) ENST00000455286(lincRNA)
ENST00000523671(lincRNA) ENST00000452514(lincRNA) ENST00000398474(lincRNA)(uc021sbx.1 uc001yid.2)

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat MEG3 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate MEG3
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for MEG3
Predesigned siRNA for gene silencing in human, mouse, rat MEG3
Clone
Products:
     
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for MEG3
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEG3
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MEG3
Addgene plasmids for MEG3 
Primer
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Browse OriGene qPCR
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MEG3
  Search QuantiTect SYBR Green Assays in human, mouse, rat MEG3
  QuantiFast Probe-based Assays in human, mouse, rat MEG3
Flow Cytometry
Products:
   

 
eBioscience FlowRNA Probe Sets ( VA6-13006) for MEG3 

Additional mRNA sequence: 

AB032607.1 AF052114.1 AK092707.1 AK098378.1 AK124580.1 AY314975.1 BC036602.1 BC036882.1 
BC062783.1 BC092509.1 BX161432.1 BX161452.1 BX247998.1 BX248012.1 GQ183494.1 GQ183495.1 
GQ183496.1 GQ183497.1 GQ183498.1 GQ183499.1 GQ183500.1 GQ183501.1 GQ183502.1 GQ183503.1 
NR_002766.2 NR_003530.2 NR_003531.3 NR_033358.1 NR_033359.1 NR_033360.1 NR_046464.1 NR_046465.2 
NR_046466.1 NR_046467.1 NR_046468.2 NR_046469.1 NR_046470.2 NR_046471.1 NR_046472.1 NR_046473.1 

Selected DOTS entries (see all 85):

DT.100892831  DT.97812871  DT.95196617  DT.455127  DT.95103845  DT.100892857  DT.95207522  DT.455076 
DT.100803337  DT.97764803  DT.100771275  DT.100045101  DT.100833667  DT.95196716  DT.91961664  DT.95366306 
DT.101985491  DT.95196719  DT.100045099  DT.307796  DT.97816231  DT.100892843  DT.100837676  DT.100892870 

976 AceView cDNA sequences (see top 24):

CB069647 R98221 BU790174 AJ413186 CR606010 H91065 BQ416812 AI874325 
BX399541 AI214764 BQ129987 AI967972 CA865965 CR608449 BU579722 AA968737 
BM875450 CR617022 CR620703 BI837843 BM510493 BE552022 BX347225 BQ183148 
CR620657 CF454067 Z40298 AI424534 BM721386 BX356998 AW237127 AI801328 
AI493259 BX398082 CR592849 CR618544 BX462852 BX445327 CR620241 AI368233 
AA904190 CR623957 BM512260 CB068049 BM876329 CR621793 AI138899 BQ717638 
BQ718013 AA722764 AA319096 AA779239 AI133545 AI299753 AJ413187 BX460093 
AA987892 BU786085 AI342797 CR608797 AF052114 CR610233 CR615598 BU787606 
AA587544 BX449881 BU947295 BE222690 CD722544 BM315103 CR603291 BX952525 
CR596535 AA625740 BX247998 AI352365 BU687787 AW236979 BX440738 BX422356 
AW964176 BX440609 AI637819 AW593813 BM271960 BX441531 AK124580 BM055113 
BQ181140 AA722579 BI439601 BX397338 BX161432 AW515017 CR603748 AI401572 
AW237013 AL133820 BX422438 AI302250 BE551364 CR591136 BM805094 AW161496 
AI332300 CR598389 CN483371 AF119863 AW896035 BX406370 AI366496 BU070270 
AI024488 BU580862 AW316731 AW163035 CR593817 AA894424 BF056354 AI189406 
BQ023646 BF109085 BE500971 AI223081 BQ548989 CR612108 BQ716711 BE669505 
BU784805 AL035808 CR624712 CR597219 AA297065 BX422267 AI125171 AK098378 
CR603886 BU790470 BU952631 AI240743 BF057815 CB070135 BX462855 AI018638 
BQ417116 AW014491 BU782673 BQ270798 BI915088 BX371175 CR609941 BQ548879 
BX099173 BM930045 BM507210 AI870856 BQ270557 BF059280 BX092514 BE503216 
BM509444 AI621180 BU751924 CR591736 CD513101 BX398582 AI802182 BQ549685 
CR611497 CR613369 CR610066 CR609760 CR614788 BU069931 BM511324 CA772548 
AA025909 BU783107 BU075693 CR607907 BU579625 BX358341 BU788946 BM313904 
BQ447322 AY314975 BE155780 BX248012 AA579349 CR626265 CR620087 BM507054 
BM510363 CK904952 BX353476 AL042643 CR612008 H93453 BU075874 BM887958 
AI199915 AA987697 BQ130070 BM506704 BX326145 BM722506 CR602474 AA351773 
CR615599 BI913162 BX432727 BU069827 CB216396 BX444313 BU783773 BE550258 
BX161452 AI268349 BQ185478 BX438953 BU070170 BX403373 BX396701 AI657197 
BX408790 BQ638092 BX429896 CB268967 H48532 AV691186 AW004002 BQ549308 
BU789202 BI544285 AW090068 BM263035 BM920614 BQ706198 BF944910 AV729489 
BM857657 AL039025 BG620698 CB243349 BX408697 BX408189 BE671478 BM055413 
AW771691 BM919525 BQ549202 R97241 AI652156 AI061167 AA297227 BC051294 
AI950273 BQ719859 BQ575489 BQ129947 BM906142 AW148855 AA298957 AA343112 
AV689832 AW138857 AV708377 BU950864 BX407662 BU727542 AW590055 BM679161 
CA943793 AA350087 AI248895 AK092504 AI634109 BC036882 BX418977 BE220754 
AI038726 W73830 BX346951 AK127864 AV727351 BF435811 AI188681 BX405678 
BI600997 BX326047 BM903574 BM804755 BG716521 AI459255 AI690267 H73440 
H67586 BX459919 BM716949 BM699430 AW956533 AI374672 BE673794 BM313642 
BI838477 BE045535 BX407747 AI962167 AA610121 BE049555 BX407693 AI346588 
BQ721264 CB146088 CB156762 BI545362 BM919491 BQ187826 BC062783 AI370446 
BX472960 AL042942 BM512019 AL603210 BG654831 CN479847 AA788892 BM920327 
AB032607 AI968392 BX450006 BM544142 BX111451 BX509220 BE811117 BX429337 
BF757582 BX408219 AI091315 AL712621 BQ581130 BF433565 BM504444 AU252496 
BX427898 BG010030 AA429727 CA943189 BC023543 CB241663 BI457289 BQ771670 
AI672054 BM683586 AA327773 BU071521 AA297100 BX478515 AA429656 H93454 
CA391561 AI797089 BE465010 BU681765 BQ268259 BX356972 BX448225 BX443856 
BX428872 BX463221 BM509198 BM893616 BX444450 BX429869 BG149462 BX429093 
CA949980 AI133465 AI342082 BM722286 AK126659 T50097 BX453064 BX330409 
BE155782 BX367139 AI453538 BM966850 BX427197 CA866255 BX498325 BX444351 
CD300268 BU783619 AA378850 BM508181 BM054960 BI438508 BM722672 AI638278 
AI174720 R44918 BF056041 AK092707 AA984335 BX388604 BX353475 CN481802 
BI913368 BU681590 BQ774315 AV692560 AA918364 BM565480 BX448226 C21164 
BE348824 BF311869 BX367552 BX346167 BI524001 BX326323 BQ267994 BE811119 
AA297821 AA348506 BI766509 AL042644 BI553463 AI292216 AW897540 BU787882 
BU580404 AI277747 BF115526 BX411177 BE671399 BX405426 BQ477456 R12264 
BX442877 BX354606 BX335796 BU678061 CF541159 AV709428 AW089342 BQ270591 
BU784045 AW003239 BX449785 AA722062 BQ575886 AK057522 Z44363 AI697564 
N55284 BQ581661 BU070059 CD243229 AW207761 AL599338 H71131 AV701976 
BX325060 BQ016490 CB154926 BX451950 BX325123 BX408226 BU738529 BX463384 
AA678332 BX426730 BM679015 BQ477876 BU579968 AV685380 BU070003 BF195282 
BQ130198 H91969 AI266648 BX385939 N90143 BX643408 CD238875 AA483847 
AI003540 AA351535 BX429998 N72524 BQ716544 BX459667 AV684463 AV709310 
BU579805 AA777328 BX368151 BE674246 BM875701 AI146279 BX479281 BX422612 
BX408784 BQ581991 BF061825 BM929634 AA701267 AA319170 BX336001 H62465 
BG619988 AK123878 AA582558 AW590523 BX422168 CA771714 BE262969 BU071298 
BU782628 BX325059 AA342665 CD251795 BE811124 BI770703 AA368167 AA326520 
AI632499 BQ787527 BI552705 AA442765 BG009566 BU786542 BX332484 BM142609 
BG703541 AV660040 AI205863 AV693188 AL708109 BG619996 BX471315 BM055212 
BM311016 BE218575 AA329370 AW157066 AI969268 BX346166 BQ267620 BX449784 
AK055725 BQ269256 AW817306 BI160994 AV706943 AI337141 AI494251 BF433098 
BF110815 AI681544 BG700039 BI603062 AW956454 AA319866 BX412723 BX354605 
AW081786 BQ130320 BM687248 AV688678 AV723467 AA864431 BX347279 BX429954 
H91361 AA054858 AW156990 BE699599 AA319377 BF882608 BM544172 AA297093 
BV202012 AW892793 H73768 BU075784 AI968579 CB989014 AV753036 BG896653 
AA972349 BX374820 BM565623 BF446820 AW079014 BQ723199 AA378929 BF997615 
BU069445 BE671107 AV688028 AA002103 H89924 AA318543 N53565 W17372 
BU783666 BU069661 BI050706 BX336000 BI032505 AL706407 AW170102 BG820393 
AI651103 N55357 AI867847 BX407756 H40310 AA777077 BX432728 AA318859 
AV702612 AV684461 AI143719 W85946 BV204924 W67892 AA326681 T98871 
AA699845 CA773340 BI838293 BG719704 AI457219 BG434362 N78818 BF925433 
BX346811 BQ548748 AA297678 AA564146 R91574 T08737 AA988898 CK004916 
AA034073 AI014279 BF994607 BM507366 BX478899 AI654556 H71305 BX450687 
AL035801 BF437913 BU947650 AA349200 AI367110 BG194761 AI133721 BI524541 
AA296981 AI638405 CB154821 BX444221 BM314810 AA377762 R11658 BU075590 
R89121 CA393017 BE672598 R94675 BX429130 R44788 BE930635 BI712978 
BG014281 BQ270834 BF942873 AV695947 BQ067825 AA587566 N51408 BI458022 
AA620289 H59227 BX352101 BU101708 AW957355 AA948316 AA297021 AI143174 
BI049309 AA984278 BG015185 BE699627 AA628340 N54358 H70901 H59610 
AA608939 AV685582 AI298157 H59650 AA378645 BG999764 BE771644 BM809044 
N92066 BI916294 R42971 BQ368536 AA319172 BG011031 BM264590 BG104698 
BI055388 BQ130786 AW371545 BX408696 AA329153 BG009564 C17126 H91329 
BF849848 W25097 W88477 H54457 W69081 W93422 R92223 AW196226 
W73864 D81154 BQ370737 BQ181864 BG004177 AI689792 AW016235 AI273614 
AA927501 AW263368 AI000703 BM876591 BQ669975 AV748482 AW961532 BU781965 
BF994597 D61523 BM504225 H82401 R87223 AV694165 BX451951 BQ718723 
AA002104 BU950452 R94676 BF956762 AA319435 H45995 H79052 BQ285898 
H51546 BE383106 BF987174 H82658 BX388426 H49428 BF314353 BU950166 
BF093598 BF854849 AV750210 AA029032 AW197392 T50040 BM687087 H69465 
BX423733 BI767968 BI052387 BG570819 W88715 BG014716 BX471020 AU252497 
H70689 BF772049 BI818211 BG005205 AW958338 AW872813 AV706475 H70899 
H71130 BX367665 BF854850 AV693628 AV704361 BI032985 BG009540 W38427 
BG013560 BG013548 BF998500 H78029 AA328911 AV748249 BU579864 AA699757 
AA927999 R97987 AV753072 H54194 H62541 AV704581 BF950694 BF362115 
W80682 BQ776936 AA969743 AV751283 T83176 AA910954 BF961363 H91435 
BX460799 W85841 BU783352 AV745845 AI207892 H73009 BG013257 R84442 
BG003219 BX336044 AV748976 BG008531 AV722591 BF993484 N77363 BF956396 
BQ370138 H48704 AA318761 H62151 AV749927 AA029246 BG009547 AA317250 
BE930972 W95826 BG011039 N76324 BI058848 R97197 BU101707 BE046799 
H59415 BX336043 AV748809 BX500153 BU071278 N57752 AV699879 BQ130239 
T90649 BQ370677 BF768651 BF741576 BM807525 BF843192 W88716 W95825 
BF994602 BI050272 BF110644 H87083 N59719 R16781 AA298914 AW897544 
BI051553 BI054758 BM808176 AW384297 BI049934 AA676792 BE466794 AA025506 
R99460 R01986 BF364954 BX422422 BX484792 H62609 AW770726 R00535 
AV690806 H71307 AV748261 AV748693 R97198 H58263 BI055552 H49427 
AV747610 CK005350 BX429449 BQ343008 AW582515 H58896 N66923 BM509370 
BM857829 BX450283 H67308 BX443802 N76892 R91627 BI050157 R87222 
AV705420 BX430003 AV749581 R99461 H68518 BG003215 CK004478 H58895 
AW954931 AV748189 T93776 H58998 R97242 BQ370730 AV752977 AW134636 
AW898161 H69871 BI050384 AW817314 N56264 BX405744 AA432355 R18076 
BM894185 R16481 BF997377 T93821 H74152 BE767017 BF989854 H51547 
BE155774 BX459796 BF997618 BG013547 BF996505 BF364941 BF996475 BF350717 
H74199 R91818 BG012902 R28916 AA090535 BQ366470 W07248 R00637 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for MEG3:RNAdb

MEG3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGATTGTCAT
MEG3 Expression
About this image


MEG3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 15) fully expand
 
 Mesenchymal Stem Cells
         Mesenchymal Stem Cells Subcutaneous White Adipose
         Umbilical cord-derived mesenchymal stem cells (family)
 
 Bone (Muscoskeletal System)    fully expand to see all 3 entries
         Mandibular Process
 
 Kidney (Urinary System)    fully expand to see all 3 entries
         Metanephros
 
 Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
         Wharton's jelly-derived stem cells
 
 Neural Tube (Nervous System)    fully expand to see all 2 entries
         Mesencephalic Basal Plate
         Floor plate-like cells
MEG3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MEG3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.654863
    Custom PCR Arrays for MEG3
Primer
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEG3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for MEG3 gene from Selected species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Meg35 maternally expressed 3   --   12 (60.25 cM) 109541001 


ENSEMBL Gene Tree for MEG3 (if available)
TreeFam Gene Tree for MEG3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MEG3 (see all 776)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs676749441,2
C--81487177(+) AAACT-/GT/TG 
        
GGTCA
16 -- int11NA 2
rs1390033171,2
C--81492625(+) TCCGC-/CCTCCTCC 16 -- int10--------
rs116279931,2
C,F,A,H--82281996(+) TCCCAC/ACTGAG 15 -- us2k116Minor allele frequency- A:0.36NS EA NA WA CSA 1053
rs733475901,2
C,F--82282027(+) CGTCAA/GCTCAT 16 -- us2k12Minor allele frequency- G:0.04WA 120
rs1919000481,2
--82282042(+) TTGTGA/GGGCTG 16 -- us2k10--------
rs1834513421,2
--82282103(+) GGGTGC/TGTGGC 16 -- us2k10--------
rs1866262341,2
C--82282181(+) GCGTGC/TCCCTC 16 -- us2k10--------
rs1913183721,2
--82282194(+) CTCTGC/TCCCCG 16 -- us2k10--------
rs1838131081,2
C--82282298(+) CTGTTC/TCCTAG 16 -- us2k10--------
rs1173052731,2
F--82282554(+) TCTATC/GTCCCC 16 -- us2k11Minor allele frequency- G:0.02NA 120

HapMap Linkage Disequilibrium report for MEG3 (101245747 - 101327368 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for MEG3:    About this table    
Variant IDTypeSubtypePubMed ID
nsv509549CNV Insertion20534489
dgv1982n71CNV Loss21882294
nsv902241CNV Loss21882294
nsv902240CNV Loss21882294
nsv902237CNV Loss21882294
nsv832876CNV Loss17160897
nsv470669CNV Loss18288195
nsv827055CNV Gain20364138
esv2751158CNV Gain17911159

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing MEG3
DNA2.0 Custom Variant and Variant Library Synthesis for MEG3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605636    OMIM disorders: --

2 diseases for MEG3:    
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maternal uniparental disomy, chromosome 14    uniparental disomy, paternal, chromosome 14

1 disease from the University of Copenhagen DISEASES database for MEG3:
Seminoma

Find genes that share disorders with MEG3           About GenesLikeMe

Genetic Association Database (GAD): MEG3

Export disorders for MEG3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MEG3 gene, integrated from 10 sources (see all 42):
(articles sorted by number of sources associating them with MEG3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. (PubMed id 10759892)1, 2, 3, 9 Miyoshi N.... Ishino F. (Genes Cells 2000)
  2. Long non-coding RNA MEG3 inhibits the proliferation of cervical carcinoma cells through the induction of cell cycle arrest and apoptosis. (PubMed id 23790166)1, 3 Qin R....Guo F. (Neoplasma 2013)
  3. The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. (PubMed id 19966805)1, 4 Wallace C....Clayton D.G. (Nat. Genet. 2010)
  4. Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. (PubMed id 15644399)1, 9 Zhao J....Klibanski A. (J. Clin. Endocrinol. Metab. 2005)
  5. Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes. (PubMed id 18176563)1, 9 Kagami M.... Ogata T. (Nat. Genet. 2008)
  6. Methylation status of imprinted genes DLK1-GTL2, MEST (PEG1), ZAC (PLAGL1), and LINE-1 elements in spermatozoa of normozoospermic men, unlike H19 imprinting control regions, is not associated with idiopathic recurrent spontaneous miscarriages. (PubMed id 23415968)1 Ankolkar M....Balasinor N.H. (Fertil. Steril. 2013)
  7. Downregulated MEG3 activates autophagy and increases cell proliferation in bladder cancer. (PubMed id 23295831)1 Ying L....Qiu F. (Mol Biosyst 2013)
  8. MEG3: a novel long noncoding potentially tumour-suppressing RNA in meningiomas. (PubMed id 23307326)1 Balik V....Hajduch M. (J. Neurooncol. 2013)
  9. Expression of cell growth negative regulators MEG3 and GADD45I^ is lost in most sporadic human pituitary adenomas. (PubMed id 21850407)1 Mezzomo L.C....Kohek M.B. (Pituitary 2012)
  10. MEG3 noncoding RNA: a tumor suppressor. (PubMed id 22393162)1 Zhou Y....Klibanski A. (J. Mol. Endocrinol. 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55384 HGNC: 14575 AceView: MEG3 Ensembl:ENSG00000214548 euGenes: HUgn55384
ECgene: MEG3 H-InvDB: MEG3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MEG3 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MEG3 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MEG3 gene:
Search GeneIP for patents involving MEG3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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