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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MEG3 Gene

RNA gene GIFtS: 34
GCID: GC14P101245

Maternally Expressed 3 (Non-Protein Coding)

(Previous name: maternally expressed 3)

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 3

Aliases
Maternally Expressed 3 (Non-Protein Coding)¹ ²		LINC00023²
GTL2² ⁵		NCRNA00023²
Long Intergenic Non-Protein Coding RNA 23¹		PRO0518²
Maternally Expressed 3¹		PRO2160²
Non-Protein Coding RNA 23¹		prebp1²
FP504²

External Ids:	HGNC: 14575¹	Entrez Gene: 55384²	Ensembl: ENSG00000214548⁷	OMIM: 605636⁵	UniProtKB: Q9UI56³

Export aliases for MEG3 gene to outside databases

Previous GC identifers: GC14P098688 GC14P095112 GC14P099282 GC14P099287 GC14P099285 GC14P100363 GC14P100364 GC14P100368 GC14P100371 GC14P100373 GC14P101292 GC14P081473

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MEG3 Gene:

This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been

transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many

normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits

tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene

expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is

a lncRNA tumor suppressor. (provided by RefSeq, Mar 2012)

GeneCards Summary for MEG3 Gene:

MEG3 (maternally expressed 3 (non-protein coding)) is an RNA gene, and is affiliated with the lncRNA class. Diseases associated with MEG3 include maternal uniparental disomy, chromosome 14, and uniparental disomy, paternal, chromosome 14.

Gene Wiki entry for MEG3 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.2 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MEG3 gene promoter:
Max1 CREB deltaCREB Olf-1 c-Myc
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for MEG3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEG3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32 Ensembl cytogenetic band: 14q32.2 HGNC cytogenetic band: 14q32.2

MEG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEG3 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P101245: view genomic region (about GC identifiers)

Start:	101,245,747 bp from pter	End:	101,327,368 bp from pter
Size:	81,622 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: YYY4_HUMAN, Q9UI56 (See protein sequence)

Recommended Name: Very putative protein from MEG3 locus

Size: 68 amino acids; 7791 Da

Caution: Product of a dubious gene prediction. There is no evidence of expression of this protein. The MEG3

(Maternally Expressed) gene probably codes for a RNA

Explore the universe of human proteins at neXtProt for MEG3: NX_Q9UI56

MEG3 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : --

Human Recombinant Protein Products for MEG3:

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Assay Products for MEG3:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

LNCRNA: Long non-coding RNAs

ProtoNet protein and cluster: Q9UI56

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
8 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Meg3):

cellular	embryogenesis	growth/size	homeostasis/metabolism	liver/biliary system
mortality/aging	muscle	respiratory system

MEG3 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for MEG3: Meg3^tm1Itl Meg3^tm1Kono

inGenious Targeting Laboratory - Custom generated mouse model solutions for MEG3

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MEG3

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MEG3

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MEG3

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MEG3
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEG3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MEG3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MEG3 (YYY4)

Search CenterWatch for drugs/clinical trials and news about MEG3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for MEG3:

Maternally expressed 3 (non-protein coding)

Hs.654863 [show with all ESTs]

Unigene Representative Sequence: NR_046473

18/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):

ENST00000556407(lincRNA) ENST00000429159(lincRNA)(uc010txe.2 uc010txd.2 uc010avz.2 uc010txf.2 uc001yib.3)

ENST00000520714(lincRNA) ENST00000522771(lincRNA) ENST00000424076(lincRNA)(uc021sbw.1) ENST00000423456(lincRNA)(uc001yhy.3)

ENST00000521404(lincRNA) ENST00000556736(lincRNA)(uc001yhz.3 uc010txg.2) ENST00000451743(lincRNA)(uc001yhw.3 uc010txb.2)

ENST00000398518(lincRNA) ENST00000554639(lincRNA)(uc010txc.2 uc001yie.3) ENST00000452120(lincRNA)

ENST00000519709(lincRNA)(uc010txh.2) ENST00000412736(lincRNA)(uc001yic.3) ENST00000455286(lincRNA)

ENST00000523671(lincRNA) ENST00000452514(lincRNA) ENST00000398474(lincRNA)(uc021sbx.1 uc001yid.2)

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEG3
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for MEG3
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Clone Products:		Browse OriGene untagged/tagged cDNA clones in CMV expression vector OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for MEG3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEG3
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MEG3
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Primer Products:		Browse OriGene qPCR
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat MEG3
		Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEG3
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Additional mRNA sequence:

AB032607.1 AF052114.1 AK092707.1 AK098378.1 AK124580.1 AY314975.1 BC036602.1 BC036882.1

BC062783.1 BC092509.1 BX161432.1 BX161452.1 BX247998.1 BX248012.1 GQ183494.1 GQ183495.1

GQ183496.1 GQ183497.1 GQ183498.1 GQ183499.1 GQ183500.1 GQ183501.1 GQ183502.1 GQ183503.1

NR_002766.2 NR_003530.2 NR_003531.3 NR_033358.1 NR_033359.1 NR_033360.1 NR_046464.1 NR_046465.2

NR_046466.1 NR_046467.1 NR_046468.2 NR_046469.1 NR_046470.2 NR_046471.1 NR_046472.1 NR_046473.1

24/85 DOTS entries (see all 85):

DT.100892831 DT.97812871 DT.95196617 DT.455127 DT.95103845 DT.100892857 DT.95207522 DT.455076

DT.100803337 DT.97764803 DT.100771275 DT.100045101 DT.100833667 DT.95196716 DT.91961664 DT.95366306

DT.101985491 DT.95196719 DT.100045099 DT.307796 DT.97816231 DT.100892843 DT.100837676 DT.100892870

24/976 AceView cDNA sequences (see all 976):

BE222690 CR609941 BF059280 BQ270557 BX371175 CD722544 BX449881 CR610233

AF052114 AI342797 BX440609 AI637819 AW593813 BM271960 BX441531 AK124580

BM055113 BQ181140 AA722579 BI439601 BX397338 BX161432 AW515017 CR603748

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for MEG3:none

MEG3 expression in normal human tissues (normalized intensities) MEG3 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGATTGTCAT

About this image

MEG3 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/24 selected tissues (see all 24) fully expand


Kidney (Urinary System) fully expand to see all 4 entries
Metanephros
visceral organ/metanephros/nephrogenic zone

Lower Urinary Tract (Urinary System) fully expand to see all 4 entries
visceral organ/urogenital sinus/primitive bladder

Bone (Muscoskeletal System) fully expand to see all 3 entries
Mandibular Process

Umbilical Cord (Extraembryonic Tissues) fully expand to see all 3 entries
Wharton's jelly-derived stem cells

Eye (Sensory Organs) fully expand to see all 2 entries
Mature Rod Bipolar Cells Inner Nuclear Layer
Human Trabecular Meshwork Cells (HTMC)

Genevestigator expression for MEG3

SOURCE GeneReport for Unigene cluster: Hs.654863

SABiosciences Custom PCR Arrays for MEG3

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEG3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for MEG3 gene from 1 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Meg3⁵	maternally expressed 3	--		12 (60.25 cM) 109541001

ENSEMBL Gene Tree for MEG3 (if available)
TreeFam Gene Tree for MEG3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs67674944^1,2	C	--	81487177(+)	`AAACT-/GT/TG GGTCA`	16	--	int¹		1		NA	2
rs139003317^1,2	C	--	81492625(+)	`TCCGC-/CCTCCTCC`	16	--	int¹		0	--	--	--	--
rs11627993^1,2	C,F,A,H	--	82281996(+)	`TCCCAC/ACTGAG`	15	--	us2k¹		16		NS EA NA WA CSA	1053
rs73347590^1,2	C,F	--	82282027(+)	`CGTCAA/GCTCAT`	16	--	us2k¹		2		WA	120
rs191900048^1,2		--	82282042(+)	`TTGTGA/GGGCTG`	16	--	us2k¹		0	--	--	--	--
rs183451342^1,2		--	82282103(+)	`GGGTGC/TGTGGC`	16	--	us2k¹		0	--	--	--	--
rs186626234^1,2	C	--	82282181(+)	`GCGTGC/TCCCTC`	16	--	us2k¹		0	--	--	--	--
rs191318372^1,2		--	82282194(+)	`CTCTGC/TCCCCG`	16	--	us2k¹		0	--	--	--	--
rs183813108^1,2	C	--	82282298(+)	`CTGTTC/TCCTAG`	16	--	us2k¹		0	--	--	--	--
rs117305273^1,2	F	--	82282554(+)	`TCTATC/GTCCCC`	16	--	us2k¹		1		NA	120

HapMap Linkage Disequilibrium report for MEG3 (101245747 - 101327368 bp)

Structural Variations
Database of Genomic Variants (DGV) 9 variations for MEG3: About this table

Variant ID	Type	Subtype	PubMed ID
nsv509549	CNV	Insertion	20534489
dgv1982n71	CNV	Loss	21882294
nsv902241	CNV	Loss	21882294
nsv902240	CNV	Loss	21882294
nsv902237	CNV	Loss	21882294
nsv832876	CNV	Loss	17160897
nsv470669	CNV	Loss	18288195
nsv827055	CNV	Gain	20364138
esv2751158	CNV	Gain	17911159

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing MEG3

DNA2.0 Custom Variant and Variant Library Synthesis for MEG3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 605636 OMIM disorders: --

12 diseases for MEG3: About MalaCards

maternal uniparental disomy, chromosome 14 uniparental disomy, paternal, chromosome 14 seminoma pituitary tumors

pituitary adenoma myelodysplastic syndromes acute myeloid leukemia meningioma

adenoma type 1 diabetes myeloid leukemia leukemia

1 disease from the University of Copenhagen DISEASES database for MEG3:

Seminoma

MEG3 for disorders About GeneDecksing

Genetic Association Database (GAD): MEG3

Export disorders for MEG3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MEG3 gene, integrated from 9 sources (see all 38):
(articles sorted by number of sources associating them with MEG3)

Utopia: connect your pdf to the dynamic
world of online information

Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. (PubMed id 10759892)^{1, 2, 3, 9} Miyoshi N.... Ishino F. (2000)
Long non-coding RNA MEG3 inhibits the proliferation of cervical carcinoma cells through the induction of cell cycle arrest and apoptos is. (PubMed id 23790166)^{1, 3} Qin R....Guo F. (2013)
The imprinted DLK1-MEG3 gene region on chromosome 14q 32.2 alters susceptibility to type 1 diabetes. (PubMed id 19966805)^{1, 4} Wallace C....Clayton D.G. (2010)
Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. (PubMed id 15644399)^{1, 9} Zhao J....Klibanski A. (2005)
Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes. (PubMed id 18176563)^{1, 9} Kagami M.... Ogata T. (2008)
Methylation status of imprinted genes DLK1-GTL2, MEST (PEG1), ZAC (PLAGL1), and LINE-1 elements in spermatozoa of normozoospermic men, unlike H19 imprinting control regions, is not associated with idiopathic recurr ent spontaneous miscarriages. (PubMed id 23415968)¹ Ankolkar M....Balasinor N.H. (2013)
Downregulated MEG3 activates autophagy and increases c ell proliferation in bladder cancer. (PubMed id 23295831)¹ Ying L....Qiu F. (2013)
MEG3: a novel long noncoding potentially tumour-suppre ssing RNA in meningiomas. (PubMed id 23307326)¹ Balik V....Hajduch M. (2013)
Expression of cell growth negative regulators MEG3 and GADD45g is lost in most sporadic human pituitary adenomas. (PubMed id 21850407)¹ Mezzomo L.C....Kohek M.B. (2012)
MEG3 noncoding RNA: a tumor suppressor. (PubMed id 22393162)¹ Zhou Y....Klibanski A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55384	HGNC: 14575	AceView: MEG3	Ensembl:ENSG00000214548	euGenes: HUgn55384
ECgene: MEG3	H-InvDB: MEG3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MEG3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MEG3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MEG3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MEG3 gene:
Search GeneIP for patents involving MEG3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for MEG3
	Browse OriGene qPCR primer pairs and template standards		Browse OriGene Protein Over-expression Lysates
	OriGene Custom Mass Spec		Browse OriGene clones
	Browse OriGene qSTAR qPCR primer pairs		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	Browse OriGene ORF clones		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MEG3		OriGene Custom Protein Services for MEG3

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MEG3
	QIAGEN SeqTarget long-range PCR primers for resequencing MEG3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEG3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEG3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEG3
	Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEG3

	GenScript Custom Purified and Recombinant Proteins Services for MEG3		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for MEG3
	GenScript Custom Assay Services for MEG3		GenScript Custom Superior Antibodies Services for MEG3
	GenScript Custom overexpressing Cell Line Services for MEG3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Search Tocris compounds for MEG3 (YYY4)

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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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	Search for Antibodies for MEG3 at Abcam
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Search LifeMap BioReagents cell lines for MEG3

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEG3

	Browse SwitchGear 3'UTR luciferase reporter plasmids for MEG3
	Browse SwitchGear Promoter luciferase reporter plasmids for MEG3

Search ThermoFisher Antibodies for MEG3

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MEG3

	inGenious Targeting Laboratory - Custom generated mouse model solutions for MEG3
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MEG3

Customized:

	lentivirus for stable overexpression of MEG3
	lentivirus expression plasmids for stable overexpression of MEG3
	adenovirus for overexpression of MEG3

Search LSBio for Antibodies for MEG3

Customized transgenic rodents for:

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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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MEG3 Gene

Maternally Expressed 3 (Non-Protein Coding)

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MEG3 Gene

Maternally Expressed 3 (Non-Protein Coding)

Aliasesfor MEG3 gene

Summariesfor MEG3 gene

Genomic Viewsfor MEG3 gene

Proteinsfor MEG3 gene

Protein Domains /Familiesfor MEG3 gene

Functionfor MEG3 gene

Pathways & Interactionsfor MEG3 gene

Drugs & Compoundsfor MEG3 gene

Transcriptsfor MEG3 gene

Expression for MEG3 gene

Orthologsfor MEG3 gene

Paralogsfor MEG3 gene

Genomic Variantsfor MEG3 gene

Disorders / Diseasesfor MEG3 gene

Publicationsfor MEG3 gene

External Searches for MEG3 gene

Genome Databases showing MEG3 gene

Other Databases showing MEG3 gene

Specialized Databases showing MEG3 gene

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Aliases
for MEG3 gene

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for MEG3 gene

Genomic Views
for MEG3 gene

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for MEG3 gene

Protein Domains /
Families
for MEG3 gene

Function
for MEG3 gene

Pathways & Interactions
for MEG3 gene

Drugs & Compounds
for MEG3 gene

Transcripts
for MEG3 gene

Expression
for MEG3 gene

Orthologs
for MEG3 gene

Paralogs
for MEG3 gene

Genomic Variants
for MEG3 gene

Disorders / Diseases
for MEG3 gene

Publications
for MEG3 gene

Intellectual Property
for MEG3 gene

Products
for MEG3 gene