Aliases for MEG3 Gene
Subcategory (RNA class) for MEG3 Gene
Quality Score for this RNA gene is
Aliases for MEG3 Gene
External Ids for MEG3 Gene
- HGNC: 14575
- Entrez Gene: 55384
- Ensembl: ENSG00000214548
- OMIM: 605636
Previous GeneCards Identifiers for MEG3 Gene
- GC14P098688
- GC14P095112
- GC14P099282
- GC14P099287
- GC14P099285
- GC14P100363
- GC14P100364
- GC14P100368
- GC14P100371
- GC14P100373
- GC14P101292
- GC14P081473
- GC14P101245
- GC14P101214
- GC14P101795
- GC14P102088
- GC14P102322
- GC14P102493
- GC14P102668
- GC14P102840
Summaries for MEG3 Gene
-
This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor suppressor. [provided by RefSeq, Mar 2012]
GeneCards Summary for MEG3 Gene
MEG3 (Maternally Expressed 3 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with MEG3 include Kagami-Ogata Syndrome and Temple Syndrome. Among its related pathways are LncRNA-mediated mechanisms of therapeutic resistance.
Additional gene information for MEG3 Gene
- Monarch Initiative
- Search for MEG3 at DataMed
- Search for MEG3 at HumanCyc
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEG3 Gene
Genomics for MEG3 Gene
GeneHancer (GH) Regulatory Elements for MEG3 Gene
Regulatory Element Products
Genomic Locations for MEG3 Gene
- chr14:100,779,410-100,861,031
- (GRCh38/hg38)
- Size:
- 81,622 bases
- Orientation:
- Plus strand
- chr14:101,245,747-101,327,368
- (GRCh37/hg19)
Genomic View for MEG3 Gene
- Cytogenetic band:
-
- 14q32.2 by Ensembl
- 14q32.2 by Entrez Gene
- 14q32.2 by HGNC


RefSeq DNA sequence for MEG3 Gene
Proteins for MEG3 Gene
Protein Expression for MEG3 Gene
Post-translational modifications for MEG3 Gene
Antibody Products
- antibodies-online: Search results for available MEG3 related products ranked by validation data
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Protein Products
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Assay Products
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No data available for DME Specific Peptides for MEG3 Gene
Domains & Families for MEG3 Gene
Gene Families for MEG3 Gene
Suggested Antigen Peptide Sequences for MEG3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains and UniProtKB/Swiss-Prot for MEG3 Gene
Function for MEG3 Gene
Phenotypes From GWAS Catalog for MEG3 Gene
Animal Model Products
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-
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CRISPR Products
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-
Vectors and viruses for KO, Activation, Repression, and more
miRNA for MEG3 Gene
- miRTarBase miRNAs that target MEG3
miRNA Products
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Inhibitory RNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MEG3
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-
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No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MEG3 Gene
Localization for MEG3 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MEG3 Gene
Pathways & Interactions for MEG3 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | LncRNA-mediated mechanisms of therapeutic resistance |
Pathways by source for MEG3 Gene
1 BioSystems pathway for MEG3 Gene
Interacting Proteins for MEG3 Gene
No data available for SIGNOR curated interactions for MEG3 Gene
Transcripts for MEG3 Gene
mRNA/cDNA for MEG3 Gene
- (40) Additional mRNA sequences :
- (976) Selected AceView cDNA sequences:
- (27) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MEG3 Gene
CRISPR Products
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-
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miRNA Products
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Inhibitory RNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MEG3
- genomics-online: cdna clones - Search results for available MEG3 gene related products
- orf clones - Search results for available MEG3 gene related products
- Applied Biological Materials Clones for MEG3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MEG3 Gene
mRNA differential expression in normal tissues according to GTEx for MEG3 Gene
NURSA nuclear receptor signaling pathways regulating expression of MEG3 Gene:
MEG3SOURCE GeneReport for Unigene cluster for MEG3 Gene:
Hs.654863Primer Products
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEG3 Gene
Orthologs for MEG3 Gene
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | SNORD112 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | SNORD112 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | SNORD112 34 |
|
ManyToMany |
- Species where no ortholog for MEG3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for MEG3 Gene
No data available for Paralogs for MEG3 Gene
Variants for MEG3 Gene
SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000004293 | -- | 100,855,781(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
rs1000069088 | -- | 100,825,398(+) | C/T | upstream_transcript_variant | |
rs1000080532 | -- | 100,849,316(+) | T/G | intron_variant, non_coding_transcript_variant | |
rs1000098373 | -- | 100,860,945(+) | G/A | genic_downstream_transcript_variant, non_coding_transcript_variant | |
rs1000133179 | -- | 100,849,577(+) | A/G | intron_variant, non_coding_transcript_variant |
Additional Variant Information for MEG3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MEG3 Gene
Disorders for MEG3 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
kagami-ogata syndrome |
|
|
temple syndrome |
|
|
silver-russell syndrome |
|
|
Additional Disease Information for MEG3
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MEG3 Gene
Publications for MEG3 Gene
- Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. (PMID: 10759892) Miyoshi N … Ishino F (Genes to cells : devoted to molecular & cellular mechanisms 2000) 2 3 22 58
- Long non-coding RNA MEG3 inhibits the proliferation of cervical carcinoma cells through the induction of cell cycle arrest and apoptosis. (PMID: 23790166) Qin R … Guo F (Neoplasma 2013) 2 3 58
- The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. (PMID: 19966805) Wallace C … Clayton DG (Nature genetics 2010) 3 44 58
- Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes. (PMID: 18176563) Kagami M … Ogata T (Nature genetics 2008) 3 22 58
- Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. (PMID: 15644399) Zhao J … Klibanski A (The Journal of clinical endocrinology and metabolism 2005) 3 22 58
Products for MEG3 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MEG3
- antibodies-online: Search results for available MEG3 related products ranked by validation data
- antibodies-online: Search results for available MEG3 related products ranked by validation data
- antibodies-online: Search results for available MEG3 related products ranked by validation data
- Search GeneTex for Antibodies for MEG3
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Sources for MEG3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
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- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew