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MEG3 Gene

RNA gene GIFtS: 35
GCID: GC14P101245

Maternally Expressed 3 (Non-Protein Coding)

(Previous name: maternally expressed 3)

See MEG3-related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 6.4

Aliases
Maternally Expressed 3 (Non-Protein Coding)¹ ²		LINC00023²
GTL2² ⁵		NCRNA00023²
Long Intergenic Non-Protein Coding RNA 23¹		PRO0518²
Maternally Expressed 3¹		PRO2160²
Non-Protein Coding RNA 23¹		prebp1²
FP504²

External Ids:	HGNC: 14575¹	Entrez Gene: 55384²	Ensembl: ENSG00000214548⁷	OMIM: 605636⁵	UniProtKB: Q9UI56³

ORGUL members:	fRNAdb¹⁰:FR395646 FR361442 FR306562 FR072345 FR223715
	NCBI¹³:BC036602 XR_000167 AY314975
	NONCODE¹⁴:n338494 n409198 n344478 n405606 n406131	see all 9
	RNAdb¹⁵:RNZ11975 ASO2088 LIT3318 LIT3321 RNZ11976	see all 8

Export aliases for MEG3 gene to outside databases

Previous GC identifers: GC14P098688 GC14P095112 GC14P099282 GC14P099287 GC14P099285 GC14P100363 GC14P100364 GC14P100368 GC14P100371 GC14P100373 GC14P101292 GC14P081473

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MEG3 Gene:

This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been

transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many

normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits

tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene

expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is

a lncRNA tumor suppressor. (provided by RefSeq, Mar 2012)

GeneCards Summary for MEG3 Gene:

MEG3 (maternally expressed 3 (non-protein coding)) is an RNA gene, and is affiliated with the lncRNA class. Diseases associated with MEG3 include maternal uniparental disomy, chromosome 14, and uniparental disomy, paternal, chromosome 14.

Gene Wiki entry for MEG3 Gene

fRNAdb sequence ontologies for MEG3 - the ORGUL cluster for this gene includes several descriptions:
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.
antisense_RNA - Antisense RNA is RNA that is transcribed from the coding, rather than the template, strand of DNA. It is therefore complementary to mRNA.
mature_transcript - A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.

View fRNAdb secondary structures for MEG3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000014.8 NC_018925.2 NT_026437.13

Regulatory elements:

Regulatory transcription factor binding sites in the MEG3 gene promoter:
Max1 CREB deltaCREB Olf-1 c-Myc
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search Chromatin IP Primers for MEG3

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEG3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32 Ensembl cytogenetic band: 14q32.2 HGNC cytogenetic band: 14q32.2

MEG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEG3 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P101245: view genomic region (about GC identifiers)

Start:	101,245,747 bp from pter	End:	101,327,368 bp from pter
Size:	81,622 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: YYY4_HUMAN, Q9UI56 (See protein sequence)

Recommended Name: Very putative protein from MEG3 locus

Size: 68 amino acids; 7791 Da

Caution: Product of a dubious gene prediction. There is no evidence of expression of this protein. The MEG3

(Maternally Expressed) gene probably codes for an RNA

Explore the universe of human proteins at neXtProt for MEG3: NX_Q9UI56

Explore proteomics data for MEG3 at MOPED

See MEG3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

MEG3 Human Recombinant Protein Products:

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	Search antibodies-online for peptides for MEG3

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	antibodies-online kits for MEG3

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

LNCRNA: Long non-coding RNAs

ProtoNet protein and cluster: Q9UI56

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
7 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Meg3):

cellular	embryogenesis	growth/size/body	liver/biliary system	mortality/aging
muscle	respiratory system

Find genes that share phenotypes with MEG3 About GenesLikeMe

Animal Models:
MGI mouse knock-outs for MEG3: Meg3^tm1Itl Meg3^tm1Kono

genOway: Develop your customized and physiologically relevant rodent model for MEG3

miRNA Products:		Block miRNA regulation of human, mouse, rat MEG3 using miScript Target Protectors
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In Situ Assay
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Flow Cytometry
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
mitochondrion	2
cytosol	1
extracellular	1
peroxisome	1

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for MEG3
Interactions:

GeneGlobe Interaction Network for MEG3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for MEG3 (YYY4)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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4 fRNAdb Secondary structures:

Unigene Cluster for MEG3:

Maternally expressed 3 (non-protein coding)

Hs.654863 [show with all ESTs]

Unigene Representative Sequence: NR_046473

Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):

ENST00000556407(lincRNA) ENST00000429159(lincRNA)(uc010txe.2 uc010txd.2 uc010avz.2 uc010txf.2 uc001yib.3)

ENST00000520714(lincRNA) ENST00000522771(lincRNA) ENST00000424076(lincRNA)(uc021sbw.1) ENST00000423456(lincRNA)(uc001yhy.3)

ENST00000521404(lincRNA) ENST00000556736(lincRNA)(uc001yhz.3 uc010txg.2) ENST00000451743(lincRNA)(uc001yhw.3 uc010txb.2)

ENST00000398518(lincRNA) ENST00000554639(lincRNA)(uc010txc.2 uc001yie.3) ENST00000452120(lincRNA)

ENST00000519709(lincRNA)(uc010txh.2) ENST00000412736(lincRNA)(uc001yic.3) ENST00000455286(lincRNA)

ENST00000523671(lincRNA) ENST00000452514(lincRNA) ENST00000398474(lincRNA)(uc021sbx.1 uc001yid.2)

miRNA Products:		Block miRNA regulation of human, mouse, rat MEG3 using miScript Target Protectors
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		Predesigned siRNA for gene silencing in human, mouse, rat MEG3

Clone Products:		Browse OriGene untagged/tagged cDNA clones in CMV expression vector OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for MEG3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEG3
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		QuantiFast Probe-based Assays in human, mouse, rat MEG3

Flow Cytometry
Products:

eBioscience FlowRNA Probe Sets ( VA6-13006) for MEG3

Additional mRNA sequence:

AB032607.1 AF052114.1 AK092707.1 AK098378.1 AK124580.1 AY314975.1 BC036602.1 BC036882.1

BC062783.1 BC092509.1 BX161432.1 BX161452.1 BX247998.1 BX248012.1 GQ183494.1 GQ183495.1

GQ183496.1 GQ183497.1 GQ183498.1 GQ183499.1 GQ183500.1 GQ183501.1 GQ183502.1 GQ183503.1

NR_002766.2 NR_003530.2 NR_003531.3 NR_033358.1 NR_033359.1 NR_033360.1 NR_046464.1 NR_046465.2

NR_046466.1 NR_046467.1 NR_046468.2 NR_046469.1 NR_046470.2 NR_046471.1 NR_046472.1 NR_046473.1

Selected DOTS entries (see all 85):

DT.100892831 DT.97812871 DT.95196617 DT.455127 DT.95103845 DT.100892857 DT.95207522 DT.455076

DT.100803337 DT.97764803 DT.100771275 DT.100045101 DT.100833667 DT.95196716 DT.91961664 DT.95366306

DT.101985491 DT.95196719 DT.100045099 DT.307796 DT.97816231 DT.100892843 DT.100837676 DT.100892870

Selected AceView cDNA sequences (see all 976):

CB069647 R98221 BU790174 AJ413186 CR606010 H91065 BQ416812 AI874325

BX399541 AI214764 BQ129987 AI967972 CA865965 CR608449 BU579722 AA968737

BM875450 CR617022 CR620703 BI837843 BM510493 BE552022 BX347225 BQ183148

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for MEG3:RNAdb

MEG3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGATTGTCAT

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MEG3 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 15) fully expand


Mesenchymal Stem Cells
Mesenchymal Stem Cells Subcutaneous White Adipose
Umbilical cord-derived mesenchymal stem cells (family)

Bone (Muscoskeletal System) fully expand to see all 3 entries
Mandibular Process

Kidney (Urinary System) fully expand to see all 3 entries
Metanephros

Umbilical Cord (Extraembryonic Tissues) fully expand to see all 3 entries
Wharton's jelly-derived stem cells

Neural Tube (Nervous System) fully expand to see all 2 entries
Mesencephalic Basal Plate
Floor plate-like cells

MEG3 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

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MEG3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.654863

Custom PCR Arrays for MEG3

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		Pre-validated RT² qPCR Primer Assay in human, mouse / rat MEG3
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEG3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for MEG3 gene from Selected species (see all 3) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Meg3⁵	maternally expressed 3	--		12 (60.25 cM) 109541001

ENSEMBL Gene Tree for MEG3 (if available)
TreeFam Gene Tree for MEG3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs67674944^1,2	C	--	81487177(+)	`AAACT-/GT/TG GGTCA`	16	--	int¹		1		NA	2
rs139003317^1,2	C	--	81492625(+)	`TCCGC-/CCTCCTCC`	16	--	int¹		0	--	--	--	--
rs11627993^1,2	C,F,A,H	--	82281996(+)	`TCCCAC/ACTGAG`	15	--	us2k¹		16		NS EA NA WA CSA	1053
rs73347590^1,2	C,F	--	82282027(+)	`CGTCAA/GCTCAT`	16	--	us2k¹		2		WA	120
rs191900048^1,2		--	82282042(+)	`TTGTGA/GGGCTG`	16	--	us2k¹		0	--	--	--	--
rs183451342^1,2		--	82282103(+)	`GGGTGC/TGTGGC`	16	--	us2k¹		0	--	--	--	--
rs186626234^1,2	C	--	82282181(+)	`GCGTGC/TCCCTC`	16	--	us2k¹		0	--	--	--	--
rs191318372^1,2		--	82282194(+)	`CTCTGC/TCCCCG`	16	--	us2k¹		0	--	--	--	--
rs183813108^1,2	C	--	82282298(+)	`CTGTTC/TCCTAG`	16	--	us2k¹		0	--	--	--	--
rs117305273^1,2	F	--	82282554(+)	`TCTATC/GTCCCC`	16	--	us2k¹		1		NA	120

HapMap Linkage Disequilibrium report for MEG3 (101245747 - 101327368 bp)

Structural Variations
Database of Genomic Variants (DGV) 9 variations for MEG3: About this table

Variant ID	Type	Subtype	PubMed ID
nsv509549	CNV	Insertion	20534489
dgv1982n71	CNV	Loss	21882294
nsv902241	CNV	Loss	21882294
nsv902240	CNV	Loss	21882294
nsv902237	CNV	Loss	21882294
nsv832876	CNV	Loss	17160897
nsv470669	CNV	Loss	18288195
nsv827055	CNV	Gain	20364138
esv2751158	CNV	Gain	17911159

Site Specific Mutation Identification with PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing MEG3

DNA2.0 Custom Variant and Variant Library Synthesis for MEG3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605636 OMIM disorders: --

2 diseases for MEG3:
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maternal uniparental disomy, chromosome 14 uniparental disomy, paternal, chromosome 14

1 inferred disease relationship from the University of Copenhagen DISEASES database for MEG3:

Seminoma

Find genes that share disorders with MEG3 About GenesLikeMe

Genetic Association Database (GAD): MEG3

Export disorders for MEG3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MEG3 gene, integrated from 10 sources (see all 42):
(articles sorted by number of sources associating them with MEG3)

Utopia: connect your pdf to the dynamic
world of online information

Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. (PubMed id 10759892)^{1, 2, 3, 9} Miyoshi N.... Ishino F. (Genes Cells 2000)
Long non-coding RNA MEG3 inhibits the proliferation of cervical carcinoma cells through the induction of cell cycle arrest and apoptosis. (PubMed id 23790166)^{1, 3} Qin R....Guo F. (Neoplasma 2013)
The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. (PubMed id 19966805)^{1, 4} Wallace C....Clayton D.G. (Nat. Genet. 2010)
Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. (PubMed id 15644399)^{1, 9} Zhao J....Klibanski A. (J. Clin. Endocrinol. Metab. 2005)
Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes. (PubMed id 18176563)^{1, 9} Kagami M.... Ogata T. (Nat. Genet. 2008)
Methylation status of imprinted genes DLK1-GTL2, MEST (PEG1), ZAC (PLAGL1), and LINE-1 elements in spermatozoa of normozoospermic men, unlike H19 imprinting control regions, is not associated with idiopathic recurrent spontaneous miscarriages. (PubMed id 23415968)¹ Ankolkar M....Balasinor N.H. (Fertil. Steril. 2013)
Downregulated MEG3 activates autophagy and increases cell proliferation in bladder cancer. (PubMed id 23295831)¹ Ying L....Qiu F. (Mol Biosyst 2013)
MEG3: a novel long noncoding potentially tumour-suppressing RNA in meningiomas. (PubMed id 23307326)¹ Balik V....Hajduch M. (J. Neurooncol. 2013)
Expression of cell growth negative regulators MEG3 and GADD45I^ is lost in most sporadic human pituitary adenomas. (PubMed id 21850407)¹ Mezzomo L.C....Kohek M.B. (Pituitary 2012)
MEG3 noncoding RNA: a tumor suppressor. (PubMed id 22393162)¹ Zhou Y....Klibanski A. (J. Mol. Endocrinol. 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55384	HGNC: 14575	AceView: MEG3	Ensembl:ENSG00000214548	euGenes: HUgn55384
ECgene: MEG3	H-InvDB: MEG3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MEG3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MEG3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MEG3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MEG3 gene:
Search GeneIP for patents involving MEG3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015

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Maternally Expressed 3 (Non-Protein Coding)

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MEG3 Gene

Maternally Expressed 3 (Non-Protein Coding)

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