MEG3 Gene

Aliases
for MEG3 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC14P098688 GC14P095112 GC14P099282 GC14P099287 GC14P099285 GC14P100363 GC14P100364 GC14P100368 GC14P100371 GC14P100373 GC14P101292 GC14P081473

Summaries
for MEG3 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for MEG3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000014.8  NC_018925.2  NT_026437.13  

Browse SwitchGear Promoter luciferase reporter plasmids

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEG3

MEG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P101245:  view genomic region     (about GC identifiers)

Proteins
for MEG3 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for MEG3: NX_Q9UI56

Explore proteomics data for MEG3 at MOPED


See MEG3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

MEG3 Human Recombinant Protein Products:

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	Search antibodies-online for proteins for MEG3
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MEG3 Antibody Products:

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MEG3 Assay Products:

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	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for MEG3
	antibodies-online kits for MEG3

Domains /
Families
for MEG3 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9UI56

Function
for MEG3 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Localization
for MEG3 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Pathways & Interactions
for MEG3 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Drugs & Compounds
for MEG3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for MEG3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Unigene Cluster for MEG3:

miRNA Products:		Block miRNA regulation of human, mouse, rat MEG3 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate MEG3
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MEG3
		Predesigned siRNA for gene silencing in human, mouse, rat MEG3

Clone Products:		Browse OriGene untagged/tagged cDNA clones in CMV expression vector OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for MEG3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEG3
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MEG3
		Addgene plasmids for MEG3

Primer Products:		Browse OriGene qPCR
		Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MEG3
		Search QuantiTect SYBR Green Assays in human, mouse, rat MEG3
		QuantiFast Probe-based Assays in human, mouse, rat MEG3

Flow Cytometry Products:

eBioscience FlowRNA Probe Sets ( VA6-13006) for MEG3

Additional mRNA sequence: 

Selected DOTS entries (see all 85):

Selected AceView cDNA sequences (see all 976):

Expression
for MEG3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for MEG3:RNAdb

MEG3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGATTGTCAT

About this image

Mesenchymal Stem Cells
Mesenchymal Stem Cells Subcutaneous White Adipose
Umbilical cord-derived mesenchymal stem cells (family)
Bone (Muscoskeletal System)    fully expand to see all 3 entries
Mandibular Process
Kidney (Urinary System)    fully expand to see all 3 entries
Metanephros
Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
Wharton's jelly-derived stem cells
Neural Tube (Nervous System)    fully expand to see all 2 entries
Mesencephalic Basal Plate
Floor plate-like cells

Primer Products:		Browse OriGene qPCR
		Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MEG3
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		QuantiFast Probe-based Assays in human, mouse, rat MEG3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEG3

Orthologs
for MEG3 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for MEG3 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Genomic Variants
for MEG3 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MEG3 (see all 776)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs676749441,2	C	--	81487177(+)	AAACT-/GT/TG          GGTCA	16	--	int1		1		NA	2
rs1390033171,2	C	--	81492625(+)	TCCGC-/CCTCCTCC	16	--	int1		0	--	--	--	--
rs116279931,2	C,F,A,H	--	82281996(+)	TCCCAC/ACTGAG	15	--	us2k1		16		NS EA NA WA CSA	1053
rs733475901,2	C,F	--	82282027(+)	CGTCAA/GCTCAT	16	--	us2k1		2		WA	120
rs1919000481,2		--	82282042(+)	TTGTGA/GGGCTG	16	--	us2k1		0	--	--	--	--
rs1834513421,2		--	82282103(+)	GGGTGC/TGTGGC	16	--	us2k1		0	--	--	--	--
rs1866262341,2	C	--	82282181(+)	GCGTGC/TCCCTC	16	--	us2k1		0	--	--	--	--
rs1913183721,2		--	82282194(+)	CTCTGC/TCCCCG	16	--	us2k1		0	--	--	--	--
rs1838131081,2	C	--	82282298(+)	CTGTTC/TCCTAG	16	--	us2k1		0	--	--	--	--
rs1173052731,2	F	--	82282554(+)	TCTATC/GTCCCC	16	--	us2k1		1		NA	120

HapMap Linkage Disequilibrium report for MEG3 (101245747 - 101327368 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for MEG3:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv509549	CNV	Insertion	20534489
dgv1982n71	CNV	Loss	21882294
nsv902241	CNV	Loss	21882294
nsv902240	CNV	Loss	21882294
nsv902237	CNV	Loss	21882294
nsv832876	CNV	Loss	17160897
nsv470669	CNV	Loss	18288195
nsv827055	CNV	Gain	20364138
esv2751158	CNV	Gain	17911159

Site Specific Mutation Identification with PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing MEG3

DNA2.0 Custom Variant and Variant Library Synthesis for MEG3

Disorders / Diseases
for MEG3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for MEG3 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MEG3 gene, integrated from 10 sources (see all 42): (articles sorted by number of sources associating them with MEG3)

Utopia: connect your pdf to the dynamic world of online information

1. Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. (PubMed id 10759892)^{1, 2, 3, 9} Miyoshi N.... Ishino F. (Genes Cells 2000)
2. Long non-coding RNA MEG3 inhibits the proliferation of cervical carcinoma cells through the induction of cell cycle arrest and apoptosis. (PubMed id 23790166)^{1, 3} Qin R....Guo F. (Neoplasma 2013)
3. The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. (PubMed id 19966805)^{1, 4} Wallace C....Clayton D.G. (Nat. Genet. 2010)
4. Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. (PubMed id 15644399)^{1, 9} Zhao J....Klibanski A. (J. Clin. Endocrinol. Metab. 2005)
5. Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes. (PubMed id 18176563)^{1, 9} Kagami M.... Ogata T. (Nat. Genet. 2008)
6. Methylation status of imprinted genes DLK1-GTL2, MEST (PEG1), ZAC (PLAGL1), and LINE-1 elements in spermatozoa of normozoospermic men, unlike H19 imprinting control regions, is not associated with idiopathic recurrent spontaneous miscarriages. (PubMed id 23415968)¹ Ankolkar M....Balasinor N.H. (Fertil. Steril. 2013)
7. Downregulated MEG3 activates autophagy and increases cell proliferation in bladder cancer. (PubMed id 23295831)¹ Ying L....Qiu F. (Mol Biosyst 2013)
8. MEG3: a novel long noncoding potentially tumour-suppressing RNA in meningiomas. (PubMed id 23307326)¹ Balik V....Hajduch M. (J. Neurooncol. 2013)
9. Expression of cell growth negative regulators MEG3 and GADD45I^ is lost in most sporadic human pituitary adenomas. (PubMed id 21850407)¹ Mezzomo L.C....Kohek M.B. (Pituitary 2012)
10. MEG3 noncoding RNA: a tumor suppressor. (PubMed id 22393162)¹ Zhou Y....Klibanski A. (J. Mol. Endocrinol. 2012)

External Searches for MEG3 gene

Genome Databases showing MEG3 gene

Other Databases showing MEG3 gene

Specialized Databases showing MEG3 gene

Products
for MEG3 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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