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Aliases for MEG3 Gene

Subcategory (RNA class) for MEG3 Gene

lncRNA

Quality Score for this RNA gene is

3

Aliases for MEG3 Gene

  • Maternally Expressed 3 (Non-Protein Coding) 2 3
  • Long Intergenic Non-Protein Coding RNA 23 2 3
  • GTL2 3 6
  • Non-Protein Coding RNA 23 2
  • Maternally Expressed 3 2
  • NCRNA00023 3
  • LINC00023 3
  • PRO0518 3
  • PRO2160 3
  • Prebp1 3
  • FP504 3

External Ids for MEG3 Gene

ORGUL Members for MEG3 Gene

Previous GeneCards Identifiers for MEG3 Gene

  • GC14P098688
  • GC14P095112
  • GC14P099282
  • GC14P099287
  • GC14P099285
  • GC14P100363
  • GC14P100364
  • GC14P100368
  • GC14P100371
  • GC14P100373
  • GC14P101292
  • GC14P081473
  • GC14P101245

Summaries for MEG3 Gene

Entrez Gene Summary for MEG3 Gene

  • This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor suppressor. [provided by RefSeq, Mar 2012]

GeneCards Summary for MEG3 Gene

MEG3 (Maternally Expressed 3 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with MEG3 include temple syndrome and uniparental disomy, paternal, chromosome 14.

Gene Wiki entry for MEG3 Gene

fRNAdb sequence ontologies for MEG3 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • antisense_RNA: Antisense RNA is RNA that is transcribed from the coding, rather than the template, strand of DNA. It is therefore complementary to mRNA.

  • mature_transcript: A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for MEG3 Gene

Genomics for MEG3 Gene

Regulatory Elements for MEG3 Gene

Genomic Location for MEG3 Gene

Start:
100,779,410 bp from pter
End:
100,861,031 bp from pter
Size:
81,622 bases
Orientation:
Plus strand

Genomic View for MEG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEG3 Gene

Proteins for MEG3 Gene

  • Protein details for MEG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UI56-YYY4_HUMAN
    Recommended name:
    Very putative protein from MEG3 locus
    Protein Accession:
    Q9UI56
    Secondary Accessions:

    Protein attributes for MEG3 Gene

    Size:
    68 amino acids
    Molecular mass:
    7791 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MEG3 Gene

Proteomics data for MEG3 Gene at MOPED

Post-translational modifications for MEG3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MEG3 Gene

Domains for MEG3 Gene

Gene Families for MEG3 Gene

HGNC:
  • LNCRNA :Long non-coding RNAs

Protein Domains for MEG3 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for MEG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MEG3: view

No data available for UniProtKB/Swiss-Prot for MEG3 Gene

Function for MEG3 Gene

genes like me logo Genes that share phenotypes with MEG3: view

Animal Models for MEG3 Gene

MGI Knock Outs for MEG3:

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for MEG3 Gene

Localization for MEG3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEG3 Gene COMPARTMENTS Subcellular localization image for MEG3 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MEG3 Gene

Pathways for MEG3 Gene

SuperPathways for MEG3 Gene

No Data Available

Interacting Proteins for MEG3 Gene

Gene Ontology (GO) - Biological Process for MEG3 Gene

None

No data available for Pathways by source for MEG3 Gene

Transcripts for MEG3 Gene

Unigene Clusters for MEG3 Gene

Maternally expressed 3 (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEG3 Gene

No ASD Table

Relevant External Links for MEG3 Gene

GeneLoc Exon Structure for
MEG3
ECgene alternative splicing isoforms for
MEG3

Expression for MEG3 Gene

mRNA expression in normal human tissues for MEG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEG3 Gene

This gene is overexpressed in Pituitary (7.7), Brain - Cerebellum (4.6), and Brain - Cerebellar Hemisphere (4.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MEG3 Gene

SOURCE GeneReport for Unigene cluster for MEG3 Gene Hs.654863

genes like me logo Genes that share expressions with MEG3: view

No data available for mRNA Expression by UniProt/SwissProt for MEG3 Gene

Orthologs for MEG3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MEG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNORD112 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNORD112 36
  • 60 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia SNORD112 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Meg3 16
Species with no ortholog for MEG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MEG3 Gene

ENSEMBL:
Gene Tree for MEG3 (if available)
TreeFam:
Gene Tree for MEG3 (if available)

Paralogs for MEG3 Gene

No data available for Paralogs for MEG3 Gene

Variants for MEG3 Gene

Sequence variations from dbSNP and Humsavar for MEG3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs11859 -- 100,835,874(+) ATCGT(G/T)CCCTG intron-variant, nc-transcript-variant
rs941575 -- 100,829,493(+) CGCCC(C/G)ACCTC nc-transcript-variant
rs941576 -- 100,839,708(+) CGTGC(A/G)GACCC intron-variant
rs941577 -- 100,839,783(+) GAGGG(G/T)TTCCA intron-variant
rs1053896 -- 100,834,609(+) ATATC(G/T)CCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEG3 Gene

Variant ID Type Subtype PubMed ID
esv2751158 CNV Gain 17911159
nsv832876 CNV Loss 17160897
nsv902237 CNV Loss 21882294
nsv470669 CNV Loss 18288195
dgv1982n71 CNV Loss 21882294
nsv902240 CNV Loss 21882294
nsv509549 CNV Insertion 20534489
nsv827055 CNV Gain 20364138
nsv902241 CNV Loss 21882294

Relevant External Links for MEG3 Gene

HapMap Linkage Disequilibrium report
MEG3
Human Gene Mutation Database (HGMD)
MEG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEG3 Gene

Disorders for MEG3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for MEG3 Gene including...

Search for MEG3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for MEG3 Gene

Relevant External Links for MEG3

Genetic Association Database (GAD)
MEG3
genes like me logo Genes that share disorders with MEG3: view

No data available for UniProtKB/Swiss-Prot for MEG3 Gene

Publications for MEG3 Gene

  1. Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. (PMID: 10759892) Miyoshi N. … Ishino F. (Genes Cells 2000) 2 3 4 23
  2. Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. (PMID: 15644399) Zhao J. … Klibanski A. (J. Clin. Endocrinol. Metab. 2005) 3 23
  3. Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes. (PMID: 18176563) Kagami M. … Ogata T. (Nat. Genet. 2008) 3 23
  4. Long non-coding RNA MEG3 inhibits the proliferation of cervical carcinoma cells through the induction of cell cycle arrest and apoptosis. (PMID: 23790166) Qin R. … Guo F. (Neoplasma 2013) 2 3
  5. The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. (PMID: 19966805) Wallace C. … Clayton D.G. (Nat. Genet. 2010) 3 48

Products for MEG3 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MEG3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MEG3
    • Block miRNA regulation of MEG3 using miScript Target Protectors

    Sources for MEG3 Gene

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