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MEG3 Gene

RNA gene   GIFtS: 35
GCID: GC14P101245

Maternally Expressed 3 (Non-Protein Coding)

(Previous name: maternally expressed 3)
  See MEG3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 6.4

Aliases
Maternally Expressed 3 (Non-Protein Coding)1 2     LINC000232
GTL22 5     NCRNA000232
Long Intergenic Non-Protein Coding RNA 231     PRO05182
Maternally Expressed 31     PRO21602
Non-Protein Coding RNA 231     prebp12
FP5042     

External Ids:    HGNC: 145751   Entrez Gene: 553842   Ensembl: ENSG000002145487   OMIM: 6056365   UniProtKB: Q9UI563   
ORGUL members:    fRNAdb10:FR395646 FR361442 FR306562 FR072345 FR223715      
NCBI13:BC036602 XR_000167 AY314975    
NONCODE14:n338494 n409198 n344478 n405606 n406131 see all 9    
RNAdb15:RNZ11975 ASO2088 LIT3318 LIT3321 RNZ11976 see all 8    

Export aliases for MEG3 gene to outside databases

Previous GC identifers: GC14P098688 GC14P095112 GC14P099282 GC14P099287 GC14P099285 GC14P100363 GC14P100364 GC14P100368 GC14P100371 GC14P100373 GC14P101292 GC14P081473


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MEG3 Gene:
This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been
transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many
normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits
tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene
expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is
a lncRNA tumor suppressor. (provided by RefSeq, Mar 2012)

GeneCards Summary for MEG3 Gene:
MEG3 (maternally expressed 3 (non-protein coding)) is an RNA gene, and is affiliated with the lncRNA class. Diseases associated with MEG3 include maternal uniparental disomy, chromosome 14, and uniparental disomy, paternal, chromosome 14.

Gene Wiki entry for MEG3 Gene

fRNAdb sequence ontologies for MEG3 - the ORGUL cluster for this gene includes several descriptions:
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.
antisense_RNA - Antisense RNA is RNA that is transcribed from the coding, rather than the template, strand of DNA. It is therefore complementary to mRNA.
mature_transcript - A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.

View fRNAdb secondary structures for MEG3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the MEG3 gene promoter:
         Max1   CREB   deltaCREB   Olf-1   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MEG3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.2

MEG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEG3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P101245:  view genomic region     (about GC identifiers)

Start:
101,245,747 bp from pter      End:
101,327,368 bp from pter
Size:
81,622 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: YYY4_HUMAN, Q9UI56 (See protein sequence)
Recommended Name: Very putative protein from MEG3 locus  
Size: 68 amino acids; 7791 Da
Caution: Product of a dubious gene prediction. There is no evidence of expression of this protein. The MEG3
(Maternally Expressed) gene probably codes for an RNA

Explore the universe of human proteins at neXtProt for MEG3: NX_Q9UI56

Explore proteomics data for MEG3 at MOPED


See MEG3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


MEG3 Human Recombinant Protein Products:

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Search eBioscience for Proteins for MEG3 

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MEG3 Assay Products:

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Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.
Search eBioscience for ELISAs for MEG3 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
LNCRNA: Long non-coding RNAs

ProtoNet protein and cluster: Q9UI56


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     7 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Meg3):
 cellular  embryogenesis  growth/size/body  liver/biliary system  mortality/aging 
 muscle  respiratory system 

Find genes that share phenotypes with MEG3           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for MEG3: Meg3tm1Itl Meg3tm1Kono

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MEG3
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MEG3

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MEG3
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MEG3

miRNA
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Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat MEG3

Gene Editing
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEG3
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MEG3
Addgene plasmids for MEG3 

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEG3

Flow Cytometry
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eBioscience FlowRNA Probe Sets ( VA6-13006) for MEG3 


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
mitochondrion2
cytosol1
extracellular1
peroxisome1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MEG3
Interactions:

    GeneGlobe Interaction Network for MEG3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MEG3 (YYY4)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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4 fRNAdb Secondary structures:


Unigene Cluster for MEG3:

Maternally expressed 3 (non-protein coding)
Hs.654863  [show with all ESTs]
Unigene Representative Sequence: NR_046473
28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see top 18):
ENST00000556407(lincRNA) ENST00000429159(lincRNA)(uc010txe.2 uc010txd.2 uc010avz.2 uc010txf.2 uc001yib.3)
ENST00000520714(lincRNA) ENST00000522771(lincRNA) ENST00000424076(lincRNA)(uc021sbw.1) ENST00000423456(lincRNA)(uc001yhy.3)
ENST00000521404(lincRNA) ENST00000556736(lincRNA)(uc001yhz.3 uc010txg.2) ENST00000451743(lincRNA)(uc001yhw.3 uc010txb.2)
ENST00000398518(lincRNA) ENST00000554639(lincRNA)(uc010txc.2 uc001yie.3) ENST00000452120(lincRNA)
ENST00000519709(lincRNA)(uc010txh.2) ENST00000412736(lincRNA)(uc001yic.3) ENST00000455286(lincRNA)
ENST00000523671(lincRNA) ENST00000452514(lincRNA) ENST00000398474(lincRNA)(uc021sbx.1 uc001yid.2)
ENST00000555928(lincRNA) ENST00000521812(lincRNA) ENST00000398461(lincRNA) ENST00000455531(lincRNA) ENST00000524035(lincRNA)
ENST00000524131(lincRNA) ENST00000522618(lincRNA) ENST00000398460(lincRNA) ENST00000521256(lincRNA) ENST00000516892(lincRNA)(uc021sby.1)

miRNA
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Search for qRT-PCR Assays for microRNAs that regulate MEG3
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for MEG3
Predesigned siRNA for gene silencing in human, mouse, rat MEG3
Clone
Products:
     
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for MEG3
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEG3
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MEG3
Addgene plasmids for MEG3 
Primer
Products:
    
Browse OriGene qPCR
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MEG3
  Search QuantiTect SYBR Green Assays in human, mouse, rat MEG3
  QuantiFast Probe-based Assays in human, mouse, rat MEG3
Flow Cytometry
Products:
   

 
eBioscience FlowRNA Probe Sets ( VA6-13006) for MEG3 

Additional mRNA sequence: 

AB032607.1 AF052114.1 AK092707.1 AK098378.1 AK124580.1 AY314975.1 BC036602.1 BC036882.1 
BC062783.1 BC092509.1 BX161432.1 BX161452.1 BX247998.1 BX248012.1 GQ183494.1 GQ183495.1 
GQ183496.1 GQ183497.1 GQ183498.1 GQ183499.1 GQ183500.1 GQ183501.1 GQ183502.1 GQ183503.1 
NR_002766.2 NR_003530.2 NR_003531.3 NR_033358.1 NR_033359.1 NR_033360.1 NR_046464.1 NR_046465.2 
NR_046466.1 NR_046467.1 NR_046468.2 NR_046469.1 NR_046470.2 NR_046471.1 NR_046472.1 NR_046473.1 

Selected DOTS entries (see all 85):

DT.100892831  DT.97812871  DT.95196617  DT.455127  DT.95103845  DT.100892857  DT.95207522  DT.455076 
DT.100803337  DT.97764803  DT.100771275  DT.100045101  DT.100833667  DT.95196716  DT.91961664  DT.95366306 
DT.101985491  DT.95196719  DT.100045099  DT.307796  DT.97816231  DT.100892843  DT.100837676  DT.100892870 

Selected AceView cDNA sequences (see all 976):

CB069647 R98221 BU790174 AJ413186 CR606010 H91065 BQ416812 AI874325 
BX399541 AI214764 BQ129987 AI967972 CA865965 CR608449 BU579722 AA968737 
BM875450 CR617022 CR620703 BI837843 BM510493 BE552022 BX347225 BQ183148 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for MEG3:RNAdb

MEG3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGATTGTCAT
MEG3 Expression
About this image


MEG3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 15) fully expand
 
 Mesenchymal Stem Cells
         Mesenchymal Stem Cells Subcutaneous White Adipose
         Umbilical cord-derived mesenchymal stem cells (family)
 
 Bone (Muscoskeletal System)    fully expand to see all 3 entries
         Mandibular Process
 
 Kidney (Urinary System)    fully expand to see all 3 entries
         Metanephros
 
 Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
         Wharton's jelly-derived stem cells
 
 Neural Tube (Nervous System)    fully expand to see all 2 entries
         Mesencephalic Basal Plate
         Floor plate-like cells
MEG3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MEG3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.654863
    Custom PCR Arrays for MEG3
Primer
Products:
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Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MEG3
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEG3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for MEG3 gene from Selected species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Meg35 maternally expressed 3   --   12 (60.25 cM) 109541001 


ENSEMBL Gene Tree for MEG3 (if available)
TreeFam Gene Tree for MEG3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MEG3 (see all 776)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs676749441,2
C--81487177(+) AAACT-/GT/TG 
        
GGTCA
16 -- int11NA 2
rs1390033171,2
C--81492625(+) TCCGC-/CCTCCTCC 16 -- int10--------
rs116279931,2
C,F,A,H--82281996(+) TCCCAC/ACTGAG 15 -- us2k116Minor allele frequency- A:0.36NS EA NA WA CSA 1053
rs733475901,2
C,F--82282027(+) CGTCAA/GCTCAT 16 -- us2k12Minor allele frequency- G:0.04WA 120
rs1919000481,2
--82282042(+) TTGTGA/GGGCTG 16 -- us2k10--------
rs1834513421,2
--82282103(+) GGGTGC/TGTGGC 16 -- us2k10--------
rs1866262341,2
C--82282181(+) GCGTGC/TCCCTC 16 -- us2k10--------
rs1913183721,2
--82282194(+) CTCTGC/TCCCCG 16 -- us2k10--------
rs1838131081,2
C--82282298(+) CTGTTC/TCCTAG 16 -- us2k10--------
rs1173052731,2
F--82282554(+) TCTATC/GTCCCC 16 -- us2k11Minor allele frequency- G:0.02NA 120

HapMap Linkage Disequilibrium report for MEG3 (101245747 - 101327368 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for MEG3:    About this table    
Variant IDTypeSubtypePubMed ID
nsv509549CNV Insertion20534489
dgv1982n71CNV Loss21882294
nsv902241CNV Loss21882294
nsv902240CNV Loss21882294
nsv902237CNV Loss21882294
nsv832876CNV Loss17160897
nsv470669CNV Loss18288195
nsv827055CNV Gain20364138
esv2751158CNV Gain17911159

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing MEG3
DNA2.0 Custom Variant and Variant Library Synthesis for MEG3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605636    OMIM disorders: --

2 diseases for MEG3:    
About MalaCards
maternal uniparental disomy, chromosome 14    uniparental disomy, paternal, chromosome 14

1 disease from the University of Copenhagen DISEASES database for MEG3:
Seminoma

Find genes that share disorders with MEG3           About GenesLikeMe

Genetic Association Database (GAD): MEG3

Export disorders for MEG3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MEG3 gene, integrated from 10 sources (see all 42):
(articles sorted by number of sources associating them with MEG3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. (PubMed id 10759892)1, 2, 3, 9 Miyoshi N.... Ishino F. (Genes Cells 2000)
  2. Long non-coding RNA MEG3 inhibits the proliferation of cervical carcinoma cells through the induction of cell cycle arrest and apoptosis. (PubMed id 23790166)1, 3 Qin R....Guo F. (Neoplasma 2013)
  3. The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. (PubMed id 19966805)1, 4 Wallace C....Clayton D.G. (Nat. Genet. 2010)
  4. Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. (PubMed id 15644399)1, 9 Zhao J....Klibanski A. (J. Clin. Endocrinol. Metab. 2005)
  5. Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes. (PubMed id 18176563)1, 9 Kagami M.... Ogata T. (Nat. Genet. 2008)
  6. Methylation status of imprinted genes DLK1-GTL2, MEST (PEG1), ZAC (PLAGL1), and LINE-1 elements in spermatozoa of normozoospermic men, unlike H19 imprinting control regions, is not associated with idiopathic recurrent spontaneous miscarriages. (PubMed id 23415968)1 Ankolkar M....Balasinor N.H. (Fertil. Steril. 2013)
  7. Downregulated MEG3 activates autophagy and increases cell proliferation in bladder cancer. (PubMed id 23295831)1 Ying L....Qiu F. (Mol Biosyst 2013)
  8. MEG3: a novel long noncoding potentially tumour-suppressing RNA in meningiomas. (PubMed id 23307326)1 Balik V....Hajduch M. (J. Neurooncol. 2013)
  9. Expression of cell growth negative regulators MEG3 and GADD45I^ is lost in most sporadic human pituitary adenomas. (PubMed id 21850407)1 Mezzomo L.C....Kohek M.B. (Pituitary 2012)
  10. MEG3 noncoding RNA: a tumor suppressor. (PubMed id 22393162)1 Zhou Y....Klibanski A. (J. Mol. Endocrinol. 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55384 HGNC: 14575 AceView: MEG3 Ensembl:ENSG00000214548 euGenes: HUgn55384
ECgene: MEG3 H-InvDB: MEG3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MEG3 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MEG3 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MEG3 gene:
Search GeneIP for patents involving MEG3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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