Subcategory (RNA class) for MEG3 Gene
Quality Score for this RNA gene is
Aliases for MEG3 Gene
Previous GeneCards Identifiers for MEG3 Gene
This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor suppressor. [provided by RefSeq, Mar 2012]
GeneCards Summary for MEG3 Gene
MEG3 (Maternally Expressed 3 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with MEG3 include Kagami-Ogata Syndrome and Paternal 14Q32.2 Hypomethylation Syndrome. Among its related pathways are LncRNA-mediated mechanisms of therapeutic resistance.