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Aliases for MEG3 Gene

Subcategory (RNA class) for MEG3 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for MEG3 Gene

  • Maternally Expressed 3 (Non-Protein Coding) 2 3 5
  • Long Intergenic Non-Protein Coding RNA 23 2 3
  • Non-Protein Coding RNA 23 2
  • Maternally Expressed 3 2
  • Onco-LncRNA-83 3
  • NCRNA00023 3
  • LINC00023 3
  • PRO0518 3
  • PRO2160 3
  • Prebp1 3
  • FP504 3
  • GTL2 3

External Ids for MEG3 Gene

Previous GeneCards Identifiers for MEG3 Gene

  • GC14P098688
  • GC14P095112
  • GC14P099282
  • GC14P099287
  • GC14P099285
  • GC14P100363
  • GC14P100364
  • GC14P100368
  • GC14P100371
  • GC14P100373
  • GC14P101292
  • GC14P081473
  • GC14P101245
  • GC14P101214
  • GC14P101795
  • GC14P102088
  • GC14P102322

Summaries for MEG3 Gene

Entrez Gene Summary for MEG3 Gene

  • This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor suppressor. [provided by RefSeq, Mar 2012]

GeneCards Summary for MEG3 Gene

MEG3 (Maternally Expressed 3 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with MEG3 include Kagami-Ogata Syndrome and Paternal 14Q32.2 Microdeletion Syndrome.

Gene Wiki entry for MEG3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEG3 Gene

Genomics for MEG3 Gene

Regulatory Elements for MEG3 Gene

Enhancers for MEG3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F100707 1.5 FANTOM5 Ensembl ENCODE 16.4 -69.0 -68959 5.1 CTCF ESRRA MAX ZNF48 RAD21 ZFHX2 POLR2A SCRT2 SMC3 NR2F6 MEG3 MIR770 GC14P102717 PIR37335 LOC105370669
GH14F100833 0.8 Ensembl ENCODE 11.4 +59.4 59386 10.6 BCOR ESRRA ZMYM3 ZIC2 TEAD3 ZFHX2 SCRT2 FOS NFE2 ZNF600 MEG3 MIR493 MIR337 MIR127 MIR431 MIR433 MIR136 RTL1 SNORD112 MIR370
GH14F100819 1 FANTOM5 ENCODE 11.2 +47.1 47126 13.4 PKNOX1 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 SLC30A9 CBX5 DLK1 MEG3 MIR493 MIR337 MIR431 RTL1 MIR127 MIR136 MIR433 SNORD112
GH14F100883 0.5 ENCODE 10.9 +105.4 105423 2.8 ZKSCAN1 MEG3 MIR370 SNORD113-1 SNORD113-2 PPP2R5C MIR136 RTL1
GH14F101235 0.5 Ensembl 10.3 +455.9 455892 0.6 ELF3 CTCF SAP130 ARID4B ZNF48 ZIC2 RAD21 ZBTB48 ZNF143 SMC3 MIR370 MEG3 MIR127 MIR136 MIR431 MIR433 RTL1 MIR337 MIR493 SNORD113-2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MEG3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MEG3 Gene

Chromosome:
14
Start:
100,779,410 bp from pter
End:
100,861,031 bp from pter
Size:
81,622 bases
Orientation:
Plus strand

Genomic View for MEG3 Gene

Genes around MEG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEG3 Gene

Proteins for MEG3 Gene

  • Protein details for MEG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UI56-YYY4_HUMAN
    Recommended name:
    Very putative protein from MEG3 locus
    Protein Accession:
    Q9UI56

    Protein attributes for MEG3 Gene

    Size:
    68 amino acids
    Molecular mass:
    7791 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MEG3 Gene

Post-translational modifications for MEG3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MEG3 Gene

Domains & Families for MEG3 Gene

Gene Families for MEG3 Gene

Protein Domains for MEG3 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for MEG3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MEG3: view

No data available for UniProtKB/Swiss-Prot for MEG3 Gene

Function for MEG3 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MEG3 Gene

Localization for MEG3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEG3 Gene COMPARTMENTS Subcellular localization image for MEG3 gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MEG3 Gene

Pathways & Interactions for MEG3 Gene

SuperPathways for MEG3 Gene

No Data Available

Interacting Proteins for MEG3 Gene

Gene Ontology (GO) - Biological Process for MEG3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MEG3 Gene

Transcripts for MEG3 Gene

Unigene Clusters for MEG3 Gene

Maternally expressed 3 (non-protein coding):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MEG3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEG3 Gene

No ASD Table

Relevant External Links for MEG3 Gene

GeneLoc Exon Structure for
MEG3
ECgene alternative splicing isoforms for
MEG3

Expression for MEG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MEG3 Gene

mRNA differential expression in normal tissues according to GTEx for MEG3 Gene

This gene is overexpressed in Pituitary (x7.7), Brain - Cerebellum (x4.6), and Brain - Cerebellar Hemisphere (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MEG3 Gene



NURSA nuclear receptor signaling pathways regulating expression of MEG3 Gene:

MEG3

SOURCE GeneReport for Unigene cluster for MEG3 Gene:

Hs.654863
genes like me logo Genes that share expression patterns with MEG3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MEG3 Gene

Orthologs for MEG3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MEG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNORD112 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNORD112 35
  • 81 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNORD112 35
  • 60 (a)
ManyToMany
Species where no ortholog for MEG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MEG3 Gene

ENSEMBL:
Gene Tree for MEG3 (if available)
TreeFam:
Gene Tree for MEG3 (if available)

Paralogs for MEG3 Gene

No data available for Paralogs for MEG3 Gene

Variants for MEG3 Gene

Sequence variations from dbSNP and Humsavar for MEG3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10131947 -- 100,833,537(+) acagg(C/T)gtgag intron-variant
rs10132552 -- 100,834,675(+) CCGTG(C/T)CTCCT intron-variant, nc-transcript-variant
rs10134980 -- 100,827,191(+) TTGTC(A/C)GAGTC intron-variant
rs10135233 -- 100,857,426(+) CTTTC(C/T)CTGGG intron-variant
rs10140785 -- 100,834,166(+) TCCCC(G/T)CCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEG3 Gene

Variant ID Type Subtype PubMed ID
esv2751158 CNV gain 17911159
esv3635516 CNV gain 21293372
esv3635518 CNV gain 21293372
nsv470669 CNV loss 18288195
nsv483116 CNV gain 15286789
nsv509549 CNV insertion 20534489
nsv827055 CNV gain 20364138
nsv832876 CNV loss 17160897

Relevant External Links for MEG3 Gene

Human Gene Mutation Database (HGMD)
MEG3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MEG3 Gene

Disorders for MEG3 Gene

MalaCards: The human disease database

(8) MalaCards diseases for MEG3 Gene - From: ClinVar, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
kagami-ogata syndrome
  • uniparental disomy, paternal, chromosome 14
paternal 14q32.2 microdeletion syndrome
  • paternal del(14)(q32.2)
maternal 14q32.2 microdeletion syndrome
  • maternal del(14)(q32.2)
maternal 14q32.2 hypermethylation syndrome
paternal 14q32.2 hypomethylation syndrome
- elite association - COSMIC cancer census association via MalaCards
Search MEG3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MEG3

Genetic Association Database (GAD)
MEG3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEG3
genes like me logo Genes that share disorders with MEG3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEG3 Gene

Publications for MEG3 Gene

  1. Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. (PMID: 10759892) Miyoshi N. … Ishino F. (Genes Cells 2000) 2 3 4 22 64
  2. Long non-coding RNA MEG3 inhibits the proliferation of cervical carcinoma cells through the induction of cell cycle arrest and apoptosis. (PMID: 23790166) Qin R. … Guo F. (Neoplasma 2013) 2 3 64
  3. The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. (PMID: 19966805) Wallace C. … Clayton D.G. (Nat. Genet. 2010) 3 46 64
  4. Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes. (PMID: 18176563) Kagami M. … Ogata T. (Nat. Genet. 2008) 3 22 64
  5. Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. (PMID: 15644399) Zhao J. … Klibanski A. (J. Clin. Endocrinol. Metab. 2005) 3 22 64

Products for MEG3 Gene

Sources for MEG3 Gene

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