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MEFV Gene

protein-coding   GIFtS: 60

GC16M003295
Mediterranean fever
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: MEF)
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Aliases &
Descriptions
for MEFV gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases & Descriptions
Mediterranean fever1 2     MGC1265862
FMF1 2 5     MGC1265602
MEF2 3 5     Mediterranean fever protein2
TRIM201 2     marenostrin2
pyrin2     Marenostrin3

External Ids:    HGNC: 69981   Entrez Gene: 42102   Ensembl: ENSG000001033137   UniProtKB: O155533   

Search outside databases for aliases for MEFV gene

Previous GC identifers: GC16M003312 GC16M003293 GC16M003294 GC16M003232

Summaries
for MEFV gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  User Feedback		 Entrez Gene summary for MEFV:
This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity.
Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome. (provided by
RefSeq)

UniProtKB/Swiss-Prot: MEFV_HUMAN, O15553
Function: Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton
organization

Gene Wiki entry for MEFV

Genomic Views
for MEFV gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
About This Section

  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the MEFV gene upstream (promoter) region "":
NF-kappaB1   NF-kappaB   C/EBPbeta   AP-1   C/EBPalpha   p53   STAT1   STAT1beta   STAT1alpha   c-Fos   

Epigenetics:
"" SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for MEFV:  ""
MePH20182-1A   

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

MEFV Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M003295:  view genomic region     (about GC identifiers)

Start:
 3,292,028 bp from pter
End:
 3,306,627 bp from pter
Size:
 14,600 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  

Proteins
for MEFV gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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  User Feedback		 UniProtKB/Swiss-Prot: MEFV_HUMAN, O15553 (See protein sequence)
Recommended Name: Pyrin  
Size: 781 amino acids; 86444 Da
Subunit: Interacts with PSTPIP1
Subcellular location: Isoform 1: Cytoplasm, cytoskeleton. Note=Associated with microtubules and with the filamentous
actin of perinuclear filaments and peripheral lamellar ruffles
Subcellular location: Isoform 2: Nucleus
Developmental stage: First detected in bone marrow promyelocytes. Expression increases throughout myelocyte
differentiation and peaks in the mature myelomonocytic cells
PDB structures from "" and Proteopedia "" :
2WL1 (3D) ""    
Secondary accessions: Q3MJ84 Q96PN4 Q96PN5
Alternative splicing: 2 isoforms:  O15553-2   O15553-1   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_000234.1  

    ENSEMBL proteins: 
    ENSP00000339639 ENSP00000219596 


    Human Recombinant Proteins 
    ""Browse Purified and Recombinant Proteins at Millipore
    ""Browse Human Recombinant Proteins at Sigma-Aldrich
    "" Browse R&D Systems for human recombinant proteins
    ""Browse recombinant and purified proteins available from Enzo Life Sciences
    ""HuPro® and/or Recombinant Proteins from Abnova for MEFV ""
    ""Browse Origene full length recombinant human proteins expressed in human HEK293 cells
    ""Novus Biologicals Proteins for MEFV  ""
    ""Browse Sino Biological Recombinant Proteins  ""

    5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IDA11115844
    GO:0005737 cytoplasm IEA--
    GO:0005856 cytoskeleton IEA--
    GO:0005874 microtubule IEA--
    About this table

    "" MEFV for ontologies           About GeneDecksing



    Antibodies for MEFV: 
    ""Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    ""Sigma-Aldrich Antibodies for MEFV
    "" Browse R&D Systems for Antibodies
    ""Monoclonal and Polyclonal Antibodies from Abnova (MEFV)
    ""Browse Origene Antibodies ""
    ""Novus Biologicals Antibodies for MEFV
    ""Browse antibodies at Epitomics

    Assays for MEFV: 
    ""Browse Kits and Assays available from Millipore
    ""Browse ELISAs at Sigma-Aldrich
    "" Browse R&D Systems for biochemical assays
    ""Browse Enzo Life Sciences for kits & assays

    Protein Domains/
    Families
    for MEFV gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    "" MEFV for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8 ):
     IPR001870 B302
     IPR011029 DEATH-like
     IPR003879 Butyrophylin
     IPR006574 PRY
     IPR004020 Pyrin

    Graphical View of Domain Structure for InterPro Entry O15553

    ProtoNet protein and cluster: O15553

    4 Blocks protein families:
    IPB000315 B-box zinc finger signature
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB004020 Pyrin domain
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: MEFV_HUMAN, O15553
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 DAPIN domain

    Gene Function
    for MEFV gene

    (According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (MEFV)
    "" Origene 29mer shRNA kits in GFP-retroviral vector: MEFV
    Origene shRNA RFP: MEFV
    Origene basic RS shRNA: MEFV

    ""Applied Biosystems Silencer® siRNAs for MEFV
    ""Sigma-Aldrich siRNA Panels and siRNA for MEFV
    Sigma-Aldrich shRNA Panels and shRNA for MEFV
    Explore Sigma-Aldrich super-pooled esiRNAs
    Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    ""Browse iPSC Reprogramming Factors at Sigma-Aldrich
    "" Origene GFP tagged cDNA clones in CMV expression vector: MEFV
    Origene Myc/DDK tagged cDNA clones in CMV expression vector: MEFV
    Origene untagged cDNA clones in CMV expression vector: MEFV
    ""Browse Sino Biological Human cDNA Clones  ""

    UniProtKB/Swiss-Prot: MEFV_HUMAN, O15553
    Function: Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton
    organization
    Induction: In monocytes, by treatment with colchicine and IFN-alpha, and by the proinflammatory cytokines IFN-gamma,
    TNF-alpha and LPS. Repressed in monocytes by the antiinflammatory cytokines IL-10, TGF-beta and IL-4. In neutrophils,
    colchicine, TNF-alpha, LPS, IL-10, INF-alpha and IL-4 has no effect on expression. INF-gamma increases expression in
    neutrophils

    Genatlas biochemistry entry for MEFV:
    nuclear factor,marenostrin (pyrin),almost exclusively expressed in granulocytes,related to the Ro autoantigen and ret
    finger proteins and to butyrophilin,mutated in Mediterranean fever (MEFV)

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779 actin binding IDA11468188
    GO:0005515 protein binding IEA--
    GO:0008270 zinc ion binding NAS11115844
    GO:0046872 metal ion binding IEA--
    About this table

    "" MEFV for ontologies           About GeneDecksing

    Animal Models: 2 MGI mutant phenotypes (inferred from 1 allele"") (MGI details for Mefv):

    homeostasis/metabolismimmune system

    "" MEFV for phenotypes           About GeneDecksing

    Pathways & Interactions
    for MEFV gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
    About This Section

      User Feedback
    "" MEFV for pathways           About GeneDecksing

    1 "" Kegg Pathway  (Kegg details for MEFV):
      ""  hsa04621 NOD-like receptor signaling pathway

    "" SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MEFV

    5/21 Interacting proteins for MEFV (ENSP000002195963 O155532) via UniProtKB, MINT, and/or STRING (see all 21 ) ""
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PYCARDQ9ULZ32STRING: ENSP00000247470 MINT-15557 MINT-15559 MINT-15558
    MID1ENSP000003126783STRING: ENSP00000312678
    MID2ENSP000002628433STRING: ENSP00000262843
    APPBP2ENSP000000831823STRING: ENSP00000083182
    CLIP2ENSP000002233983STRING: ENSP00000223398
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954 inflammatory response IDA11468188
    About this table

    "" MEFV for ontologies           About GeneDecksing


    Drugs & Compounds
    for MEFV gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

      User Feedback
    "" MEFV for compounds           About GeneDecksing

    "" Browse drugs & compounds from Enzo Life Sciences
    ""Browse Small Molecules at Sigma-Aldrich

    "" Browse Tocris compounds for MEFV
    10/20 ""Novoseek chemical compound relationships for MEFV gene (see all 20 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    colchicine 28.58 32 11802319 (5), 14978665 (4), 14679589 (2), 11468188 (2) (see all 23)
    telithromycin 4.42 4 18073148 (1), 17405779 (1), 15705635 (1), 11062201 (1)
    erythromycin 2.00 7 18073148 (1), 17405779 (1), 16201929 (1), 16189099 (1) (see all 7)
    p205 1.51 1 15342947 (1)
    mevalonate 1.08 2 16466630 (1), 15059033 (1)
    leucine 0.89 6 19682372 (1), 18648497 (1), 15999810 (1), 15892040 (1) (see all 6)
    isoleucine 0.81 2 15231984 (1), 12924509 (1)
    phalloidin 0.70 1 11468188 (1)
    sulfasalazine 0.32 1 17408446 (1)
    azithromycin 0.23 1 18073148 (1)
    About this table


    Transcripts
    for MEFV gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
    Expression Assays from Applied Biosystems)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (MEFV)
    ""Applied Biosystems Silencer® siRNAs:  NM_000243  
    "" Origene 29mer shRNA kits in GFP-retroviral vector: MEFV
    Origene shRNA RFP: MEFV
    Origene basic RS shRNA: MEFV

    ""Sigma-Aldrich siRNA Panels and siRNA for MEFV
    Sigma-Aldrich shRNA Panels and shRNA for MEFV
    Explore Sigma-Aldrich super-pooled esiRNAs

    microRNA:""Search SABiosciences for microRNAs that regulate MEFV: ""
    Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
    NM_000243  


    Clones:"" Origene GFP tagged cDNA clones in CMV expression vector: MEFV
    Origene Myc/DDK tagged cDNA clones in CMV expression vector: MEFV
    Origene untagged cDNA clones in CMV expression vector: MEFV
    Primers:"" Origene genome-wide validated SYBR primer pairs: MEFV
    ""SABiosciences RT2 qPCR Primer Assay for MEFV: PPH13601A ""

    REFSEQ mRNAs for MEFV gene: 

    NM_000243.2  

    Additional cDNA sequence: 

    AF018080.1 AK298660.1 BC101511.1 BC101537.1 FJ785717.1 FJ785722.1 Y14441.1 

    1 DOTS entry:

    DT.103777 

    7 AceView cDNA sequences:

    AW440869 CD639999 NM_000243 AF018080 BI907993 Y14441 BI024282 

    "" highest scoring ESTs for MEFV:

    Y14441 AF018080 BI024282 AW440869 BC101511 BC101537 BI907993 BM922554 CD639999 NM_000243 

    Unigene Cluster for MEFV:

    Mediterranean fever
    Hs.632221  [show with all ESTs]
    Unigene Representative Sequence: AF018080


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000339854  ENST00000219596  

    Expression
    for MEFV gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
    About This Section

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    MEFV expression in normal and diseased human tissues

    "" Applied Biosystems TaqMan ® Gene Expression Assays for MEFV

    1""  / 2""  / 3""

    2 probe-sets matching MEFV gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    208262_x_at2, 3 U133-A 14 0.82 0.81 -- -- NM_000243 0.40 1.00 0.76 1
    208262_x_at2 U133Plus2 14 0.82 0.81 -- -- -- -- -- -- --
    About this table
    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AATAAAAAAA

    SOURCE GeneReport for Unigene cluster: Hs.632221

    UniProtKB/Swiss-Prot: MEFV_HUMAN, O15553
    Tissue specificity: Expressed in peripheral blood leukocytes, particularly in mature granulocytes and to a lesser
    extent in monocytes but not in lymphocytes. Detected in spleen, lung and muscle, probably as a result of leucocyte
    infiltration in these tissues. Not expressed in thymus, prostate, testis, ovary, small intestine, colon, heart, brain,
    placenta, liver, kidney, pancreas. Expression detected in several myeloid leukemic, colon cancer, and prostate cancer
    cell lines

    Primers:"" Origene genome-wide validated SYBR primer pairs: MEFV ""
    ""SABiosciences RT2 qPCR Primer Assay for MEFV: PPH13601A ""

    Orthologs
    for MEFV gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

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    Orthologs for MEFV gene from 4 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 MEFV1   -- Mediterranean fever 73.67(n)
    62.76(a)    		 490041  XM_547161.2  XP_547161.2 
    chimpanzee
    (Pan troglodytes)    		 MEFV1   -- Mediterranean fever 98.72(n)
    98.21(a)    		 467886  XM_523280.2  XP_523280.2 
    rat
    (Rattus norvegicus)    		 Mefv1   -- Mediterranean fever 63.44(n)
    49.82(a)    		 58923  NM_031634.1  NP_113822.1 
    mouse
    (Mus musculus)    		 Mefv1, 5 16 (1.10 cM)5
    		 Mediterranean fever1, 5 66.96(n)1
    55.2(a)1    		 544831  NM_019453.11  NP_062326.11 
     AF1434095  AV3723385  (see all 9)
    About this table        Species with no ortholog for MEFV

    ENSEMBL Gene Tree for MEFV

    Paralogs
    for MEFV gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

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    Paralogs for MEFV gene
    RFPL12  LOC7299742  RFPL32  RFPL4A2  RFPL22  RNF392  

    "" MEFV for paralogs           About GeneDecksing


    Genomic Variants
    for MEFV gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
    About This Section

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    10/188 NCBI SNPs in MEFV are shown (see all 188 )
    (Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 81)
    ABGenomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 16 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    ""
    rs27419191,2
    		C,F,O,A,H3292896(+) TGCAAT/CGACTC 1 -- ut31 ese3""30Minor allele frequency- C:0.39NA EU EA NS WA 2144""
    ""
    rs2242301,2
    		C,F,O,A,H3277904(+) TTACTA/GTTAAT 1 -- ng51 tfbs3""14Minor allele frequency- G:0.48MN EA NA EU NS 2230""
    ""
    rs27419181,2
    		C,F,A,H3292874(+) GCCACT/CCACCA 1 -- ut31""9Minor allele frequency- C:0.37NA EU EA WA 306""
    ""
    rs2242341,2
    		C,F,A3261568(-) TTTCAT/GGAAGC 1 -- ng31""19Minor allele frequency- G:0.39MN NS EA NA EU 2762""
    ""
    rs80475211,2
    		C,F,A3261578(+) ATGCAG/CTCGGG 1 -- ng31""5Minor allele frequency- C:0.18NA EU WA 216""
    --
    rs114660161,2
    		C,F3306491(-) CCAGTG/TTGCAG 2 V L ref1 mis1 ese3""7Minor allele frequency- T:0.00NA EU NS EA 500""
    --
    rs114660511,2
    		C,F3292667(-) gagacG/Caaatc 1 -- ut31 ese3""5Minor allele frequency- C:0.29NA EU 98""
    --
    rs2242271,2
    		C,F3277113(-) tttacC/Tgtgtt 1 -- ng51""5Minor allele frequency- T:0.17NA EU 94""
    ""
    rs114660241,2
    		C,F3299468(-) CCACCG/AGGTGC 2 /Q /R mis1 ref1 ese3""12Minor allele frequency- A:0.22NA EU NS EA 1004""
    ""
    rs20758491,2
    		C,F3293008(+) GGCTCC/TGTGGG 1 -- ut31 ese3""12Minor allele frequency- T:0.12NA EU NS EA 720""
    About this table

    HapMap Linkage Disequilibrium images for MEFV (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
    Database of Genomic Variants (DGV): 2 variations for MEFV
         2 CNVs: 49690 4921

    Disorders & Mutations
    for MEFV gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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    "" MEFV for disorders           About GeneDecksing

    OMIM: 608107   disorders: 249100  134610  

    UniProtKB/Swiss-Prot: MEFV_HUMAN, O15553

  • Defects in MEFV are the cause of familial Mediterranean fever autosomal recessive (ARFMF) [MIM:249100]. ARFMF
    • is an inherited disorder characterized by recurrent episodic fever, serosal inflammation and pain in the abdomen,
    chest or joints. ARFMF is frequently complicated by amyloidosis, which leads to renal failure and can be
    prophylactically treated with colchicine. ARFMF primarily affects ancestral ethnic groups living around the
    Mediterranean basin: North African Jews, Armenians, Arabs and Turks. The disease is also distributed in other
    populations including Greeks, Cypriots, Italians and Spanish, although at a lower prevalence
  • Defects in MEFV are the cause of familial Mediterranean fever autosomal dominant (ADFMF) [MIM:134610]. ADFMF
    • is characterized by periodic fever, serosal inflammation and pain in the abdomen, chest or joints as seen also in the
    autosomal recessive form of the disease. It is associated with renal amyloidosis and characterized by colchicine
    unresponsiveness

    10/125 ""Novoseek disease relationships for MEFV gene (see all 125 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    brucellosis 100.00 83 20031469 (8), 19755381 (7), 18035151 (7), 14514692 (6) (see all 38)
    familial mediterranean fever 100.00 638 16614989 (9), 9715731 (8), 16707534 (8), 15621109 (8) (see all 100)
    amyloidosis 53.13 45 15621109 (4), 12687559 (4), 17102945 (3), 15122067 (3) (see all 27)
    tumor necrosis factor receptor-associated periodic syndrome 26.80 12 15243709 (4), 20074469 (2), 9735379 (1), 16273767 (1) (see all 8)
    hereditary periodic fever 26.72 10 9715731 (2), 15071491 (2), 19877056 (1), 17911435 (1) (see all 8)
    periodic syndrome 23.10 10 16707534 (2), 14679589 (2), 19280943 (1), 16466630 (1) (see all 8)
    aa amyloidosis 21.22 14 12105243 (3), 15621109 (2), 15122067 (2), 15071491 (2) (see all 9)
    papa syndrome 20.38 7 19584923 (2), 19768193 (1), 17964261 (1), 16466630 (1) (see all 6)
    behcet disease 18.92 14 17454935 (8), 18609258 (6)
    inflammation 17.41 63 17195238 (4), 12966608 (2), 12908875 (2), 9735379 (1) (see all 58)
    About this table

    Genatlas disease: MEFV
    Mediterranean fever,excluding hyper-IgD and periodic fever syndrome,including late onset form,mild without amyloidosis
    or chronic arthritis

    GeneTests: MEFV
    Familial Mediterranean Fever

    Locus Specific Mutation Databases: MEFV
    Human Gene Mutation Database: MEFV
    Genetic Association Database: MEFV
    Human Genome Epidemiology Navigator: MEFV (122 documents)

    Medical News
    for MEFV gene

    (Possibly Related Articles in Doctor's Guide)
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    Publications
    for MEFV gene

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

      User Feedback    		10/334 PubMed articles for MEFV gene (see all 334 ):

    Search for MEFV gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

      User Feedback
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MEFV gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

      User Feedback
    Entrez Gene: 4210 HGNC: 6998 AceView: MEFV Ensembl:ENSG00000103313 euGenes: HUgn4210
    ECgene: MEFV Kegg: 4210 H-InvDB: MEFV

    Other Databases showing MEFV gene

    (According to HUGE)
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    Specialized Databases showing MEFV gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    GeneDishttp://www.tau.ac.il/lifesci/bioinfo/genedis/fmf/fmf.html
    INFEVERShttp://fmf.igh.cnrs.fr/ISSAID/infevers/disease_menu.php?n=1
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MEFV

    Intellectual Property
    for MEFV gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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      User Feedback    		Patent Information for MEFV gene: ""
    Search GeneIP for patents involving MEFV

    GeneCards and IP: ""
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search


    Services
    for MEFV gene

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
    Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
    Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
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    Products for MEFV:
    "" TaqMan ® Gene Expression Assays
    "" TaqMan ® Genotyping Assays
    		 "" Free SNP selection tool

    ""
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    ""
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    "" Explore super-pooled esiRNAs"" Browse proteins at Sigma-Aldrich
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    "" "Your Favorite Gene" Pathways"" Browse ELISAs at Sigma-Aldrich
    "" Browse iPSC Reprogramming Factors at Sigma-Aldrichfeedback


     ""  ""
    "" Antibodies  "" Primer Pairs  
    "" Cell Culture Products  "" ELISAs  
    "" Flow Cytometry Kits  "" Protease Activity Assays & Reagents  
    "" Cell Selection/Detection Kits & Reagents  "" ELISA/Assay Development Kits & Reagents  
    "" Multiplex/Array Assay Kits & Reagents  "" ELISpot Kits & Development Modules  
    "" Recombinant & Natural Proteins  

    "" Recombinant Proteins (MEFV)
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    """"""""
    "" Search for Antibodies & Assays

    "" Tagged/untagged cDNA clones
    "" Validated SYBR primer pairs
    "" Purified proteins from HEK293T cells
    "" Western blot validated antibodies
    "" shRNA in GFP-retroviral vector
    "" Custom immunoassay development
    "" Search Tocris compounds for MEFV
    "" Regulatory tfbs in MEFV upstream (promoter) region
    "" Search Chromatin IP Primers for MEFV
    "" DNA Methylation qPCR Primer Assays for MEFV
    "" RT2 qPCR Primer Assay for MEFV
    "" GNC Network for MEFV
    "" Search for microRNAs that regulate MEFV
    """"""""
    "" Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
    "" Novus Tissue Slides
    "" Antibodies for MEFV
    "" Proteins for MEFV
    "" Browse antibodies at Epitomics
    "" Browse Sino Biological Proteins and Antibodies
    "" Browse Sino Biological cDNA Clones
    "" Antibodies/Proteins Production Services
    "" Rabbit Monoclonal Antibody Platform
    "" Bulk Purchasing
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    GeneCards Homepage - Last full update: 21 May 2010 - Incremental updates: 24 May 2010 , 20 Jun 2010

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    acyl-CoA synthetase family member 3
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