MEFV Gene
protein-coding GIFtS: 63
GCID: GC16M003295
|
|
Mediterranean fever
(Previous symbol: MEF)
| |
Aliases
for MEFV gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mediterranean Fever1 2 | | Marenostrin3 | | MEF1 2 3 5 | | Pyrin1 | | FMF1 2 5 | | Marenostrin3 | | TRIM201 2 | | |
Export aliases for MEFV gene to outside databasesPrevious GC identifers: GC16M003312 GC16M003293 GC16M003294 GC16M003232 |
Summaries
for MEFV gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MEFV:
This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity.Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MEFV_HUMAN, O15553Function: Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeletonorganization
Gene Wiki entry for MEFV
|
Genomic Views
for MEFV gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MEFV gene promoter:
AML1a AP-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MEFV
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEFV |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3MEFV Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M003295: view genomic region
(about GC identifiers)
Start:
|
3,292,028 bp from pter |
End:
|
3,306,627 bp from pter |
Size:
|
14,600 bases |
Orientation:
|
minus strand |
|
Proteins
for MEFV gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MEFV_HUMAN, O15553 (See
protein sequence)Recommended Name: Pyrin Size: 781 amino acids; 86444 Da
Subunit: Interacts with PSTPIP1
Subcellular location: Isoform 1: Cytoplasm, cytoskeleton. Note=Associated with microtubules and with the filamentousactin of perinuclear filaments and peripheral lamellar ruffles
Subcellular location: Isoform 2: Nucleus
Developmental stage: First detected in bone marrow promyelocytes. Expression increases throughout myelocytedifferentiation and peaks in the mature myelomonocytic cells
1 PDB 3D structure from  and Proteopedia  for MEFV:2WL1 (3D)
Secondary accessions: D3DUC0 Q3MJ84 Q96PN4 Q96PN5Alternative splicing: 2 isoforms: O15553-2 O15553-1 Explore the universe of human proteins at neXtProt for MEFV: NX_O15553
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15553
MEFV Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_000234.1 NP_001185465.1
ENSEMBL proteins: ENSP00000219596 ENSP00000339639 ENSP00000438611 ENSP00000444615 ENSP00000444178 ENSP00000437486 ENSP00000438711 ENSP00000444471 ENSP00000445079 ENSP00000458312 ENSP00000461186 ENSP00000460551 ENSP00000460269 Reactome Protein details: O15553
Human Recombinant Protein Products for MEFV:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
MEFV for ontologies About GeneDecksing
MEFV Antibody Products:
Assay Products for MEFV: |
Protein
Domains /
Families
for MEFV gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MEFV for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry O15553ProtoNet protein and cluster: O15553 4 Blocks protein families: IPB000315 B-box zinc finger signature IPB003879 Butyrophylin C-terminal DUF signature IPB004020 Pyrin domain IPB006574 SPRY-associated domain
UniProtKB/Swiss-Prot: MEFV_HUMAN, O15553Similarity: Contains 1 B box-type zinc fingerSimilarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 DAPIN domain |
Function
for MEFV gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MEFV_HUMAN, O15553Function: Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeletonorganizationInduction: In monocytes, by treatment with colchicine and IFN-alpha, and by the proinflammatory cytokinesIFNG/IFN-gamma, TNF and bacterial lipopolysaccharides (LPS). Repressed in monocytes by the antiinflammatory cytokinesIL10/interleukin-10, TGFB1 and IL4/interleukin-4. In neutrophils, colchicine, TNF, bacterial lipopolysaccharides(LPS), IL10/interleukin-10, INF-alpha and IL4/interleukin-4 have no effect on expression. IFNG/IFN-gamma increasesexpression in neutrophils Genatlas biochemistry entry for MEFV:nuclear factor,marenostrin (pyrin),almost exclusively expressed in granulocytes,related to the Ro autoantigen and retfinger proteins and to butyrophilin,mutated in Mediterranean fever (MEFV)
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
MEFV for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for MEFV:
11 MGI mutant phenotypes (inferred from 7 alleles ) (MGI details for Mefv):
MEFV for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Mefvtm1Bhk for MEFV
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEFV (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEFV
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MEFV (NM_001198536) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MEFV | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEFV |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEFV |
|
Pathways & Interactions
for MEFV gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | | | 2 | Inflammasomes | | | 3 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for MEFV
5 
Reactome Pathways for MEFV
1 
Kegg Pathway (Kegg details for MEFV):
MEFV for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MEFV
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/12 Interacting proteins for MEFV (O155532, 3 ENSP000002195964) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
-- | -- | | GO:0006954 | inflammatory response |
IDA | 11468188 | | GO:0032691 | negative regulation of interleukin-1 beta production |
IMP | -- | | GO:0032695 | negative regulation of interleukin-12 production |
IMP | -- | | GO:0035872 | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway |
TAS | -- |
MEFV for ontologies About GeneDecksing
|
Drugs & Compounds
for MEFV gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MEFV for compounds About GeneDecksing
 Browse Tocris compounds for MEFV
8 Novoseek chemical compound relationships for MEFV gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| colchicine |
87.5 |
20 |
11802319 (5), 14978665 (1), 20051664 (1), 19534089 (1) (see all 14) |
| mnda |
63.4 |
1 |
16651415 (1) |
| mevalonate |
46.1 |
1 |
16466630 (1) |
| leucine |
11.6 |
5 |
15892040 (1), 15999810 (1), 18648497 (1), 12759408 (1) (see all 5) |
| tyrosine |
3.57 |
3 |
14595024 (2), 16724804 (1) |
| endotoxin |
0 |
2 |
12667444 (1), 17617620 (1) |
| isoleucine |
0 |
2 |
15231984 (1), 12924509 (1) |
| methionine |
0 |
2 |
10787449 (1), 12924509 (1) |
Search CenterWatch for drugs/clinical trials and news about MEFV
|
Transcripts
for MEFV gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MEFV gene (2 alternative transcripts): NM_000243.2 NM_001198536.1 Unigene Cluster for MEFV: Mediterranean fever Hs.632221 [show with all ESTs]Unigene Representative Sequence: AF01808014 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000219596(uc002cun.1 uc021tca.1) ENST00000339854(uc021tbw.1 uc021tbx.1 uc021tby.1 uc021tbz.1 uc021tcb.1)
ENST00000537682 ENST00000542898 ENST00000536980 ENST00000538326 ENST00000541159
ENST00000539145 ENST00000536379 ENST00000570511 ENST00000572244 ENST00000576315
ENST00000574583 ENST00000539154
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEFV (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEFV
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MEFV (NM_001198536) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MEFV | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEFV |
Additional cDNA sequence: AF018080.1 BC101511.1 BC101537.1 FJ785717.1 FJ785718.1 FJ785719.1 FJ785720.1 FJ785721.1 FJ785722.1 Y14441.1 1 DOTS entry: DT.103777 7 AceView cDNA sequences: AF018080 BI907993 Y14441 NM_000243 AW440869 CD639999 BI024282
GeneLoc Exon Structure
|
Expression
for MEFV gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MEFV expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATAAAAAAA
About this image
See MEFV Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MEFV
SOURCE GeneReport for Unigene cluster: Hs.632221
UniProtKB/Swiss-Prot: MEFV_HUMAN, O15553Tissue specificity: Expressed in peripheral blood leukocytes, particularly in mature granulocytes and to a lesserextent in monocytes but not in lymphocytes. Detected in spleen, lung and muscle, probably as a result of leukocyteinfiltration in these tissues. Not expressed in thymus, prostate, testis, ovary, small intestine, colon, heart, brain,placenta, liver, kidney, pancreas. Expression detected in several myeloid leukemic, colon cancer, and prostate cancercell lines
SABiosciences Expression via Pathway-Focused PCR Arrays including MEFV:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEFV
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MEFV | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEFV | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEFV | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEFV |
Orthologs
for MEFV gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MEFV gene from 2/9 species (see all 9) About this table
ENSEMBL Gene Tree for MEFV (if available)
TreeFam Gene Tree for MEFV (if available) |
Paralogs
for MEFV gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MEFV gene
- RFPL12 TRIML22 RFPL4AL12 RFPL4A2 RFPL32 RFPL22 RFPL4B2
18/68 SIMAP similar genes for MEFV using alignment to 14 protein entries: MEFV_HUMAN (see all proteins)
(see all similar genes):FAM3A LINC00596 TMEM14B TSEN2 UTY AURA2
LOC100506792 CHID1 TCEB1 FKBP3 NF2 QRICH2
ZNF212 FAM175A ZNF564 SHANK2 C14orf2 ERMAP
MEFV for paralogs About GeneDecksing
|
Genomic Variants
for MEFV gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MEFV (3292028 - 3306627 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MEFV
2 CNVs: 49690 4921
Human Gene Mutation Database (HGMD): MEFV
Locus Specific Mutation Databases (LSDB): MEFV
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEFV |
|
Disorders
/ Diseases
for MEFV gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MEFV for disorders About GeneDecksing
OMIM gene information: 608107
OMIM disorders: 249100 134610
UniProtKB/Swiss-Prot: MEFV_HUMAN, O15553
Defects in MEFV are the cause of familial Mediterranean fever autosomal recessive (ARFMF) [MIM:249100]. ARFMFis an inherited disorder characterized by recurrent episodic fever, serosal inflammation and pain in the abdomen,chest or joints. ARFMF is frequently complicated by amyloidosis, which leads to renal failure and can beprophylactically treated with colchicine. ARFMF primarily affects ancestral ethnic groups living around theMediterranean basin: North African Jews, Armenians, Arabs and Turks. The disease is also distributed in otherpopulations including Greeks, Cypriots, Italians and Spanish, although at a lower prevalence Defects in MEFV are the cause of familial Mediterranean fever autosomal dominant (ADFMF) [MIM:134610]. ADFMFis characterized by periodic fever, serosal inflammation and pain in the abdomen, chest or joints as seen also in theautosomal recessive form of the disease. It is associated with renal amyloidosis and characterized by colchicineunresponsiveness
20/67  diseases for MEFV (see all 67): About MalaCardsperiodic fever muckle-wells syndrome familial mediterranean fever, ar familial mediterranean fever
familial mediterranean fever, ad polyarteritis nodosa pyoderma gangrenosum familial cold autoinflammatory syndrome
nail-patella syndrome wells syndrome palindromic rheumatism relapsing fever
cinca syndrome blau syndrome pyoderma acute myocardial infarction
colchicine resistance aphthous stomatitis myocardial infarction hydrarthrosis
9 diseases from the University of Copenhagen DISEASES database for MEFV:Familial Mediterranean fever Brucellosis Amyloidosis Erysipelas
Autosomal recessive disease Arthritis Peritonitis Palindromic rheumatism
Pyoderma gangrenosum 10/39 Novoseek disease relationships for MEFV gene (see all 39) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| familial mediterranean fever |
98.6 |
194 |
15020340 (2), 16614989 (2), 12695165 (2), 16245224 (2) (see all 99) |
| serositis |
93 |
4 |
11182028 (1), 19091621 (1), 19530512 (1), 17489852 (1) |
| hereditary periodic fever syndromes |
91.5 |
3 |
15071491 (1), 15243709 (1), 14679589 (1) |
| muckle-wells syndrome |
88.8 |
2 |
15071491 (1), 18172447 (1) |
| cold hypersensitivity |
87.9 |
3 |
12371636 (1) |
| tumor necrosis factor receptor-associated periodic syndrome |
87.2 |
4 |
15071491 (1), 15243709 (1), 16273767 (1), 20074469 (1) |
| renal amyloidosis |
87.1 |
7 |
17469185 (2), 12401847 (1), 15720244 (1), 16118480 (1) (see all 5) |
| cinca syndrome |
83.7 |
3 |
19804406 (1), 18172447 (1) |
| amyloidosis |
83.4 |
41 |
15071491 (4), 12687559 (4), 17102945 (3), 11156548 (2) (see all 19) |
| brucellosis |
81.8 |
40 |
16245224 (3), 14978665 (1), 19091621 (1), 15243709 (1) (see all 32) |
Genatlas disease: MEFV Mediterranean fever,excluding hyper-IgD and periodic fever syndrome,including late onset form,mild without amyloidosisor chronic arthritis
GeneTests: MEFV
Familial Mediterranean Fever
Genetic Association Database (GAD): MEFV
Human Genome Epidemiology (HuGE) Navigator: MEFV (149 documents)
Export disorders for MEFV gene to outside databases
|
Publications
for MEFV gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MEFV gene, integrated from 9 sources (see all 399):
(articles sorted by number of sources associating them with MEFV) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Is the Ala138Gly alteration of MEFV gene important for amyloidosis? (PubMed id 11139244)1, 2, 4, 9 Akar E.... Akar N. (2001)
- Two novel mutations R653H and E230K in the Mediterranean fever gene associated with disease. (PubMed id 11470495)1, 2, 4, 9 Timmann C.... Horstmann R.D. (2001)
- Familial Mediterranean fever (FMF) in Lebanon and Jordan: a population genetics study and report of three novel mutations. (PubMed id 16378925)1, 2, 4 Medlej-Hashim M....Megarbane A. (2005)
- A candidate gene for familial Mediterranean fever. (PubMed id 9288094)1, 2, 3 Bernot A.... Grateau G. (1997)
- Hematopoietic-specific expression of MEFV, the gene mutated in familial Mediterranean fever, and subcellular localization of its corresponding protein, pyrin. (PubMed id 10666224)1, 2, 9 Tidow N.... Koeffler H.P. (2000)
- The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators. (PubMed id 10807793)1, 2, 9 Centola M.... Kastner D.L. (2000)
- Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway. (PubMed id 14595024)1, 2, 9 Shoham N.G....Kastner D.L. (2003)
- Reduced MEFV messenger RNA expression in patients with familial Mediterranean fever. (PubMed id 12384939)1, 2, 9 Notarnicola C....Touitou I. (2002)
- Pyrin/marenostrin mutations in familial Mediterranean fever. (PubMed id 10024914)1, 2, 9 Booth D.R.... Hawkins P.N. (1998)
- Alternative splicing at the MEFV locus involved in familial Mediterranean fever regulates translocation of the marenostrin/pyrin protein to the nucleus. (PubMed id 11115844)1, 2, 9 Papin S.... Amselem S. (2000)
|
External Searches for MEFV gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MEFV gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MEFV gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MEFV gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MEFV | Pharmacogenomics, SNPs, Pathways | | INFEVERS | http://fmf.igh.cnrs.fr/ISSAID/infevers/search.php?n=1 | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MEFV |
|
| | |
About This Section
| Patent Information for MEFV gene:
Search GeneIP for patents involving MEFV
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MEFV gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MEFV | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEFV | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEFV | | | OriGene Protein Over-expression Lysate for MEFV | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MEFV | | OriGene 3'-UTR Clone for MEFV | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEFV | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEFV | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MEFV | | OriGene Custom Protein Services for MEFV | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MEFV | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEFV | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEFV | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEFV | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEFV | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEFV |
| |
 |  |  |  | |
| | | | Search Tocris compounds for MEFV |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | MEFV Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEFV |
|  |  |  |  | | | | ThermoFisher Antibodies for MEFV |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEFV |
| |  | |
|
|
|
