MEF2D Gene
protein-coding GIFtS: 60
GCID: GC01M156433
|
|
myocyte enhancer factor 2D
| |
Aliases
for MEF2D gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Myocyte Enhancer Factor 2D1 2 | | MADS Box Transcription Enhancer Factor 2, Polypeptide D2 | | Myocyte-Specific Enhancer Factor 2D2 |
Export aliases for MEF2D gene to outside databasesPrevious GC identifers: GC01M154302 GC01M152201 GC01M153213 GC01M153650 GC01M153246 GC01M154700 GC01M127793 |
Summaries
for MEF2D gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MEF2D:
This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of thisfamily are involved in control of muscle and neuronal cell differentiation and development, and are regulated by classII histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) dueto a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis.The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results inmultiple transcript variants. (provided by RefSeq, Oct 2012)
UniProtKB/Swiss-Prot: MEF2D_HUMAN, Q14814Function: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found innumerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletaland cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the controlof cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-relatedtranscription. Plays a critical role in the regulation of neuronal apoptosis (By similarity)
Gene Wiki entry for MEF2D
|
Genomic Views
for MEF2D gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MEF2D gene promoter:
MEF-2A CREB STAT1 Sp1 p300 deltaCREB STAT3 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MEF2D
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEF2D |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q12-q23 Ensembl cytogenetic band: 1q22 HGNC cytogenetic band: 1q12-q23MEF2D Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M156433: view genomic region
(about GC identifiers)
Start:
|
156,433,519 bp from pter |
End:
|
156,470,620 bp from pter |
Size:
|
37,102 bases |
Orientation:
|
minus strand |
|
Proteins
for MEF2D gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MEF2D_HUMAN, Q14814 (See
protein sequence)Recommended Name: Myocyte-specific enhancer factor 2D Size: 521 amino acids; 55938 Da
Subunit: Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs arereleased into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with HDAC4 (inundifferentiating cells); the interaction translocates MEF2D to nuclear dots. Forms a heterodimer with MEF2A
Subcellular location: Nucleus. Note=Translocated by HDAC4 to nuclear dots
Developmental stage: Present in myotubes and also in undifferentiated myoblasts
Secondary accessions: D3DVC0 Q14815 Q5T9U5 Q5T9U6Alternative splicing: 6 isoforms: Q14814-1 Q14814-2 Q14814-3 Q14814-4 Q14814-5 Q14814-6 Explore the universe of human proteins at neXtProt for MEF2D: NX_Q14814
Post-translational modifications:
Phosphorylated on Ser-444 by CDK5 is required for Lys-439 sumoylation and inhibits transcriptional activity. Inneurons, enhanced CDK5 activity induced by neurotoxins promotes caspase 3-mediated cleavage leading to neuronapoptosis. Phosphorylation on Ser-180 can be enhanced by EGF. Phosphorylated and activated by CaMK41
Acetylated on Lys-439 by CREBBP. Deacetylated by SIRT11
Sumoylated on Lys-439 with SUMO2 but not SUMO1; which inhibits transcriptional activity and myogenic activity.Desumoylated by SENP31
Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 7 following neurotoxicity.Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptionalinactivation (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14814
MEF2D Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001258558.1 NP_005911.1
ENSEMBL proteins: ENSP00000271555 ENSP00000353803 ENSP00000388505 ENSP00000343159 ENSP00000357223 ENSP00000344705 Reactome Protein details: Q14814
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MEF2D for ontologies About GeneDecksing
MEF2D Antibody Products:
Assay Products for MEF2D: |
Protein
Domains /
Families
for MEF2D gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MEF2D for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14814ProtoNet protein and cluster: Q14814 1 Blocks protein family: IPB002100 Transcription factor
UniProtKB/Swiss-Prot: MEF2D_HUMAN, Q14814Domain: The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activitySimilarity: Belongs to the MEF2 familySimilarity: Contains 1 MADS-box domainSimilarity: Contains 1 Mef2-type DNA-binding domain |
Function
for MEF2D gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MEF2D_HUMAN, Q14814Function: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found innumerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletaland cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the controlof cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-relatedtranscription. Plays a critical role in the regulation of neuronal apoptosis (By similarity) Genatlas biochemistry entry for MEF2D:myocyte-specific enhancer binding factor 2D,interacting with members of the MyoD family of transcriptionalactivator,also interacting with TWIST to inhibit myogenesis,negatively regulated by MITR in association withHDAC1,also expressed in muscle cells
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEF2D (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEF2D (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MEF2D (NM_005920) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MEF2D | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEF2D |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEF2D |
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
IDA | -- | | GO:0000981 | sequence-specific DNA binding RNA polymerase II transcription factor activity |
IDA | -- | | GO:0003677 | DNA binding |
-- | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
NAS | 8575763 | | GO:0005515 | protein binding |
IPI | 16043483 |
MEF2D for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Mef2dtm1.1Eno for MEF2D
4 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Mef2d):
MEF2D for phenotypes About GeneDecksing
|
Pathways & Interactions
for MEF2D gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | NFAT and Cardiac Hypertrophy | | | 2 | Signal transduction_IP3 signaling | | | 3 | Immune response_Function of MEF2 in T lymphocytes | | | 4 | Signal transduction_Activation of PKC via G-Protein coupled receptor | | | 5 | Signal transduction Calcium signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 EMD Millipore Pathways for MEF2D
5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MEF2D (see all 17)
5  GeneGo (Thomson Reuters) Pathways for MEF2D
5/7  BioSystems Pathways for MEF2D (see all 7)
3 
Reactome Pathways for MEF2D
MEF2D for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MEF2D
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/72 Interacting proteins for MEF2D (Q148142, 3 ENSP000002715554) via UniProtKB, MINT, STRING, and/or I2D (see all 72)About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001649 | osteoblast differentiation |
IEA | -- | | GO:0001958 | endochondral ossification |
IEA | -- | | GO:0002062 | chondrocyte differentiation |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
-- | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- |
MEF2D for ontologies About GeneDecksing
|
Drugs & Compounds
for MEF2D gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MEF2D for compounds About GeneDecksing
 Browse Tocris compounds for MEF2D
3 Novoseek chemical compound relationships for MEF2D gene About this table
Search CenterWatch for drugs/clinical trials and news about MEF2D
|
Transcripts
for MEF2D gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MEF2D gene (2 alternative transcripts): NM_001271629.1 NM_005920.3 Unigene Cluster for MEF2D: Myocyte enhancer factor 2D Hs.314327 [show with all ESTs]Unigene Representative Sequence: AB21000510 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000348159(uc001fpb.3 uc001fpc.3 uc001fpd.3 uc009wsa.3 uc001fpe.1)
ENST00000360595 ENST00000475587 ENST00000464356 ENST00000454816 ENST00000493077
ENST00000489057 ENST00000340875 ENST00000368240 ENST00000353795
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEF2D (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEF2D (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MEF2D (NM_005920) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MEF2D | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEF2D |
Additional cDNA sequence: AB210005.1 AF086193.1 AK027180.1 AK056972.1 AK308641.1 BC018985.2 BC032479.1 BC040949.1 BC054520.1 BX640792.1 BX647226.1 L16794.1 17 DOTS entries: DT.446366 DT.456248 DT.75108971 DT.100682501 DT.100014646 DT.91751547 DT.121383071 DT.100812878 DT.92018690 DT.95291474 DT.99975797 DT.100780775 DT.121383037 DT.121383051 DT.92420001 DT.95291467 DT.97858716 24/291 AceView cDNA sequences (see all 291): CB153267 BC040949 BI962725 BF062668 AI265995 CB853070 AI628644 AA227500 AW137241 BC054520 AI867998 AI379279 CK821232 AW513169 AW316723 BC018985 AI380380 BQ940478 M79121 BM272105 BE858957 BF763262 BX479480 BM700553
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for MEF2D (see all 9) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MEF2D
|
Expression
for MEF2D gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MEF2D expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGGTGCCCC
About this image
See MEF2D Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MEF2D
SOURCE GeneReport for Unigene cluster: Hs.314327
SABiosciences Custom PCR Arrays for MEF2D
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MEF2D | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEF2D | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEF2D | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEF2D |
Orthologs
for MEF2D gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MEF2D gene from 7/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MEF2D1 |
myocyte enhancer factor 2D |
78.26(n)
84.79(a) |
|
431059 NM_001031600.1 NP_001026771.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.199912 |
X.laevis mRNA for SRF-related protein (clone SL-1) |
77.81(n) |
|
Z19124.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
mef2d2 |
myocyte enhancer factor 2d |
78.89(n) |
|
30580 NM_131317.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Mef26 |
Myocyte enhancer factor 2 |
28(a) |
1 → many |
2R(5801001-5846350) |
worm
(Caenorhabditis elegans) |
Secernentea |
mef-21 , 3 |
MEF-2 protein3
Protein MEF-21 |
74(a)3
43.15(n)1
40.45(a)1 |
|
I(9104071-9108117)3
1727321 NM_060040.41 NP_492441.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AGL336AGL216(see all 46) |
agamous-like MADS-box protein AGL21(see all 46) |
26(a)21(a)(see all 46) |
many ↔ manymany ↔ many(see all 46) |
2(11205389-11206287) 4(17835572-17838621) |
rice
(Oryza sativa) |
Liliopsida |
Os.41532 |
Oryza sativa mRNA for M79 protein |
75.32(n) |
|
AK100263.1 |
ENSEMBL Gene Tree for MEF2D (if available)
TreeFam Gene Tree for MEF2D (if available) |
Paralogs
for MEF2D gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MEF2D gene
- MEF2B2 MEF2C2 MEF2A2
6 SIMAP similar genes for MEF2D using alignment to 3 protein entries: MEF2D_HUMAN (see all proteins):DAZAP1/MEF2D fusion MEF2D variant protein MEF2A MEF2C MEF2B MEF2D/DAZAP1 fusion
MEF2D for paralogs About GeneDecksing
|
Genomic Variants
for MEF2D gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MEF2D (156433519 - 156470620 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MEF2D: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEF2D |
|
Disorders
/ Diseases
for MEF2D gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MEF2D for disorders About GeneDecksing
OMIM gene information: 600663
OMIM disorders: --
9  diseases for MEF2D: About MalaCardsacute lymphoblastic leukemia lymphoblastic leukemia embryonal carcinoma parkinson's disease
leukemia hypertension cholesterol carcinoma
neuronitis
Human Genome Epidemiology (HuGE) Navigator: MEF2D (9 documents)
Export disorders for MEF2D gene to outside databases
|
Publications
for MEF2D gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MEF2D gene, integrated from 9 sources (see all 105):
(articles sorted by number of sources associating them with MEF2D) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage. (PubMed id 8269842)1, 2, 3, 9 Breitbart R.E....Nadal-Ginard B. (1993)
- Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation. (PubMed id 16356933)1, 2, 9 Gregoire S.... Yang X.-J. (2006)
- Big mitogen-activated kinase regulates multiple members of the MEF2 protein family. (PubMed id 10849446)1, 2, 9 Kato Y.... Lee J.D. (2000)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors. (PubMed id 15743823)1, 2 Gregoire S. and Yang X.-J. (2005)
- Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain. (PubMed id 15834131)1, 2 Zhu B....Gulick T. (2005)
- Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase- mediated lysine modifications. (PubMed id 16166628)1, 2 Zhao X.... Yao T.-P. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis. (PubMed id 11904443)1, 2 Okamoto S....Lipton S.A. (2002)
- HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor. (PubMed id 10523670)1, 2 Wang A.H.... Yang X.-J. (1999)
|
External Searches for MEF2D gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MEF2D gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MEF2D gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MEF2D gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MEF2D | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MEF2D gene:
Search GeneIP for patents involving MEF2D
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MEF2D gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MEF2D | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEF2D | | Browse OriGene genome-wide validated SYBR primer pairs | | | OriGene Protein Over-expression Lysate for MEF2D | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MEF2D | | OriGene 3'-UTR Clone for MEF2D | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEF2D | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEF2D | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MEF2D | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MEF2D | | OriGene Custom Protein Services for MEF2D | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MEF2D | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEF2D | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEF2D | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEF2D | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEF2D | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEF2D |
| |
 |  |  |  | |
| | | | Search Tocris compounds for MEF2D |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | MEF2D Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEF2D |
|  |  |  | | | | Search ThermoFisher Antibodies for MEF2D |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEF2D |
|
|
|
|
