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Aliases for MEF2BNB-MEF2B Gene

Aliases for MEF2BNB-MEF2B Gene

  • MEF2BNB-MEF2B Readthrough 2 3
  • LOC729991-MEF2B Readthrough 3
  • Myocyte Enhancer Factor 2B 3
  • LOC729991-MEF2B 3
  • MEF2B 3

External Ids for MEF2BNB-MEF2B Gene

Previous GeneCards Identifiers for MEF2BNB-MEF2B Gene

  • GC19M019258

Summaries for MEF2BNB-MEF2B Gene

Entrez Gene Summary for MEF2BNB-MEF2B Gene

  • This gene represents numerous read-through transcripts that span GeneID:729991 and 100271849. Many read-through transcripts are predicted to be nonsense-mediated decay (NMD) candidates, and are thought to be non-coding. Some transcripts are predicted to be capable of translation reinitiation at a downstream AUG, resulting in expression of at least one isoform of myocyte enhancer factor 2B (MEF2B) from this read-through locus. At least one additional MEF2B variant and isoform can be expressed from a downstream promoter, and is annotated on GeneID:100271849. [provided by RefSeq, Oct 2010]

GeneCards Summary for MEF2BNB-MEF2B Gene

MEF2BNB-MEF2B (MEF2BNB-MEF2B Readthrough) is a Protein Coding gene. Among its related pathways are Ca-dependent events and L1CAM interactions. An important paralog of this gene is MEF2C.

Gene Wiki entry for MEF2BNB-MEF2B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEF2BNB-MEF2B Gene

Genomics for MEF2BNB-MEF2B Gene

Genomic Location for MEF2BNB-MEF2B Gene

Start:
19,145,567 bp from pter
End:
19,192,591 bp from pter
Size:
47,025 bases
Orientation:
Minus strand

Genomic View for MEF2BNB-MEF2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEF2BNB-MEF2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEF2BNB-MEF2B Gene

No data available for Regulatory Elements for MEF2BNB-MEF2B Gene

Proteins for MEF2BNB-MEF2B Gene

  • Protein details for MEF2BNB-MEF2B Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BNR1
    Recommended name:
    Protein MEF2BNB-MEF2B
    Protein Accession:
    H3BNR1
    Secondary Accessions:

    Protein attributes for MEF2BNB-MEF2B Gene

    Size:
    382 amino acids
    Molecular mass:
    40459 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MEF2BNB-MEF2B Gene

Proteomics data for MEF2BNB-MEF2B Gene at MOPED

Post-translational modifications for MEF2BNB-MEF2B Gene

No Post-translational modifications

Other Protein References for MEF2BNB-MEF2B Gene

No data available for DME Specific Peptides for MEF2BNB-MEF2B Gene

Domains for MEF2BNB-MEF2B Gene

Protein Domains for MEF2BNB-MEF2B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MEF2BNB-MEF2B: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MEF2BNB-MEF2B Gene

Function for MEF2BNB-MEF2B Gene

Gene Ontology (GO) - Molecular Function for MEF2BNB-MEF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with MEF2BNB-MEF2B: view

Phenotypes for MEF2BNB-MEF2B Gene

genes like me logo Genes that share phenotypes with MEF2BNB-MEF2B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MEF2BNB-MEF2B Gene

Localization for MEF2BNB-MEF2B Gene

Gene Ontology (GO) - Cellular Components for MEF2BNB-MEF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005667 transcription factor complex --
GO:0005737 cytoplasm --
GO:0030054 cell junction --
genes like me logo Genes that share ontologies with MEF2BNB-MEF2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for MEF2BNB-MEF2B Gene

Pathways for MEF2BNB-MEF2B Gene

genes like me logo Genes that share pathways with MEF2BNB-MEF2B: view

Interacting Proteins for MEF2BNB-MEF2B Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000457957%0d%0a9606.ENSP00000263119%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000080059%0d%0a9606.ENSP00000340995%0d%0a
Selected Interacting proteins: ENSP00000457957 for MEF2BNB-MEF2B Gene via STRING

Gene Ontology (GO) - Biological Process for MEF2BNB-MEF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007507 heart development --
GO:0007517 muscle organ development --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter --
genes like me logo Genes that share ontologies with MEF2BNB-MEF2B: view

Transcripts for MEF2BNB-MEF2B Gene

CRISPR Products

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MEF2BNB-MEF2B
    • Block miRNA regulation of MEF2BNB-MEF2B using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for MEF2BNB-MEF2B

    Flow Cytometry Products

    Alternative Splicing Database (ASD) splice patterns (SP) for MEF2BNB-MEF2B Gene

    No ASD Table

    Relevant External Links for MEF2BNB-MEF2B Gene

    GeneLoc Exon Structure for
    MEF2BNB-MEF2B
    ECgene alternative splicing isoforms for
    MEF2BNB-MEF2B

    Expression for MEF2BNB-MEF2B Gene

    mRNA expression in normal human tissues for MEF2BNB-MEF2B Gene

    genes like me logo Genes that share expressions with MEF2BNB-MEF2B: view

    Primer Products

    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat

    In Situ Assay Products

    No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MEF2BNB-MEF2B Gene

    Orthologs for MEF2BNB-MEF2B Gene

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MEF2BNB-MEF2B Gene

    Organism Taxonomy Gene Similarity Type Details
    mouse
    (Mus musculus)
    Mammalia Mef2b 16
    oppossum
    (Monodelphis domestica)
    Mammalia -- 36
    • 55 (a)
    OneToMany
    platypus
    (Ornithorhynchus anatinus)
    Mammalia -- 36
    • 48 (a)
    OneToMany
    chicken
    (Gallus gallus)
    Aves -- 36
    • 46 (a)
    OneToMany
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.2586 35
    zebrafish
    (Danio rerio)
    Actinopterygii mef2b 36
    • 53 (a)
    OneToMany
    worm
    (Caenorhabditis elegans)
    Secernentea mef-2 36
    • 29 (a)
    OneToMany
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RLM1 36
    • 10 (a)
    ManyToMany
    SMP1 36
    • 14 (a)
    ManyToMany
    corn
    (Zea mays)
    Liliopsida Zm.1104 35
    Species with no ortholog for MEF2BNB-MEF2B:
    • A. gosspyii yeast (Ashbya gossypii)
    • Actinobacteria (Mycobacterium tuberculosis)
    • African clawed frog (Xenopus laevis)
    • African malaria mosquito (Anopheles gambiae)
    • Alicante grape (Vitis vinifera)
    • alpha proteobacteria (Wolbachia pipientis)
    • amoeba (Dictyostelium discoideum)
    • Archea (Pyrococcus horikoshii)
    • barley (Hordeum vulgare)
    • beta proteobacteria (Neisseria meningitidis)
    • bread mold (Neurospora crassa)
    • chimpanzee (Pan troglodytes)
    • Chromalveolata (Phytophthora infestans)
    • common water flea (Daphnia pulex)
    • cow (Bos Taurus)
    • dog (Canis familiaris)
    • E. coli (Escherichia coli)
    • filamentous fungi (Aspergillus nidulans)
    • Firmicute bacteria (Streptococcus pneumoniae)
    • fission yeast (Schizosaccharomyces pombe)
    • fruit fly (Drosophila melanogaster)
    • green algae (Chlamydomonas reinhardtii)
    • honey bee (Apis mellifera)
    • K. lactis yeast (Kluyveromyces lactis)
    • lizard (Anolis carolinensis)
    • loblloly pine (Pinus taeda)
    • malaria parasite (Plasmodium falciparum)
    • medicago trunc (Medicago Truncatula)
    • moss (Physcomitrella patens)
    • orangutan (Pongo pygmaeus)
    • pig (Sus scrofa)
    • rat (Rattus norvegicus)
    • rice (Oryza sativa)
    • rice blast fungus (Magnaporthe grisea)
    • schistosome parasite (Schistosoma mansoni)
    • sea anemone (Nematostella vectensis)
    • sea squirt (Ciona intestinalis)
    • sea squirt (Ciona savignyi)
    • sea urchin (Strongylocentrotus purpuratus)
    • sorghum (Sorghum bicolor)
    • soybean (Glycine max)
    • stem rust fungus (Puccinia graminis)
    • sugarcane (Saccharum officinarum)
    • thale cress (Arabidopsis thaliana)
    • tomato (Lycopersicon esculentum)
    • toxoplasmosis (Toxoplasma gondii)
    • Trichoplax (Trichoplax adhaerens)
    • tropical clawed frog (Silurana tropicalis)
    • wheat (Triticum aestivum)

    Evolution for MEF2BNB-MEF2B Gene

    ENSEMBL:
    Gene Tree for MEF2BNB-MEF2B (if available)
    TreeFam:
    Gene Tree for MEF2BNB-MEF2B (if available)

    Paralogs for MEF2BNB-MEF2B Gene

    Paralogs for MEF2BNB-MEF2B Gene

    (3) SIMAP similar genes for MEF2BNB-MEF2B Gene using alignment to 1 proteins:

    genes like me logo Genes that share paralogs with MEF2BNB-MEF2B: view

    Variants for MEF2BNB-MEF2B Gene

    Sequence variations from dbSNP and Humsavar for MEF2BNB-MEF2B Gene

    SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
    rs1134953 -- 19,176,082(-) gcctc(A/G)ctcta intron-variant
    rs2283624 -- 19,172,371(+) TCTGG(G/T)GGGCA intron-variant
    rs2283625 -- 19,172,395(+) CATGG(G/T)CTGTC intron-variant
    rs2314035 -- 19,174,111(+) AGGAG(C/T)AGGTC intron-variant
    rs3178791 -- 19,175,413(-) gtgac(A/G)gagcg intron-variant

    Structural Variations from Database of Genomic Variants (DGV) for MEF2BNB-MEF2B Gene

    Variant ID Type Subtype PubMed ID
    nsv833779 CNV Loss 17160897
    nsv911303 CNV Loss 21882294
    nsv819543 CNV Gain 19587683
    esv2718291 CNV Deletion 23290073
    esv5981 CNV Loss 19470904
    esv2677504 CNV Deletion 23128226
    esv1336135 CNV Deletion 17803354

    Relevant External Links for MEF2BNB-MEF2B Gene

    HapMap Linkage Disequilibrium report
    MEF2BNB-MEF2B

    No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEF2BNB-MEF2B Gene

    Disorders for MEF2BNB-MEF2B Gene

    No disorders were found for MEF2BNB-MEF2B Gene.

    No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MEF2BNB-MEF2B Gene

    Publications for MEF2BNB-MEF2B Gene

    1. Human SRF-related proteins: DNA-binding properties and potential regulatory targets. (PMID: 1748287) Pollock R. … Treisman R. (Genes Dev. 1991) 3 23
    2. Mouse Mef2b gene: unique member of MEF2 gene family. (PMID: 9443808) Morisaki T. … Mukai T. (J. Biochem. 1997) 23
    3. Human myocyte-specific enhancer factor 2 comprises a group of tissue- restricted MADS box transcription factors. (PMID: 1516833) Yu Y.-T. … Nadal-Ginard B. (Genes Dev. 1992) 3
    4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

    Products for MEF2BNB-MEF2B Gene

    Sources for MEF2BNB-MEF2B Gene

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