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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MEF2BNB-MEF2B Gene

protein-coding   GIFtS: 40
GCID: GC19M019258

MEF2BNB-MEF2B readthrough

 Explore 4 diseases affiliated with
MEF2BNB-MEF2B via our new
 Human Malady Compendium 
Biological research products
for MEF2BNB-MEF2B
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
MEF2BNB-MEF2B Readthrough1 2
LOC729991-MEF2B2
MEF2B2
LOC729991-MEF2B Readthrough2
Myocyte Enhancer Factor 2B2

External Ids:    HGNC: 399791   Entrez Gene: 42072   Ensembl: ENSG000000644897   UniProtKB: H3BNR14   
ORGUL members:         
NONCODE:n335704 n407781    

Export aliases for MEF2BNB-MEF2B gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MEF2BNB-MEF2B:
This gene represents numerous read-through transcripts that span GeneID:729991 and 100271849. Many read-through
transcripts are predicted to be nonsense-mediated decay (NMD) candidates, and are thought to be non-coding. Some
transcripts are predicted to be capable of translation reinitiation at a downstream AUG, resulting in expression of at
least one isoform of myocyte enhancer factor 2B (MEF2B) from this read-through locus. At least one additional MEF2B
variant and isoform can be expressed from a downstream promoter, and is annotated on GeneID:100271849. (provided by
RefSeq, Oct 2010)

Gene Wiki entry for MEF2BNB-MEF2B (MEF2B)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MEF2BNB-MEF2B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMEF2BNB-MEF2B promoter sequence
   Search SABiosciences Chromatin IP Primers for MEF2BNB-MEF2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEF2BNB-MEF2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

MEF2BNB-MEF2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEF2BNB-MEF2B gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M019258:  view genomic region     (about GC identifiers)

Start:
19,256,376 bp from pter      End:
19,303,400 bp from pter
Size:
47,025 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

  • n407781
  • n335704
19256375 19279888 19303400 chr19

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/TrEMBL: H3BNR1 (See protein sequence)
Recommended Name: Protein MEF2BNB-MEF2B  
Size: 86 amino acids; 9392 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as
preliminary data

MEF2BNB-MEF2B Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_005910.1  
ENSEMBL proteins: 
 ENSP00000457957   ENSP00000454967  

Human Recombinant Protein Products: 
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Uscn Proteins for MEF2BNB-MEF2B


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Uscn ELISAs and CLIAs for MEF2BNB-MEF2B


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MEF2BNB-MEF2B for domains           About GeneDecksing

1 InterPro domain/family:
 IPR019320 UPF0402_NEP

Graphical View of Domain Structure for InterPro Entry H3BNR1

ProtoNet protein and cluster: H3BNR1


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA
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Inhib. RNA
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OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEF2BNB-MEF2B (see all 7)
OriGene shRNA RFP: MEF2BNB-MEF2B
OriGene siRNA: MEF2BNB-MEF2B
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEF2BNB-MEF2B

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEF2BNB-MEF2B

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----


MEF2BNB-MEF2B for ontologies           About GeneDecksing


2 GenomeRNAi human phenotypes for MEF2BNB-MEF2B:
 Decreased viability of wild-ty  Increased G2M DNA content 


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Signal transduction Calcium signaling
Signal transduction Calcium signaling1.00
2SRF and miRs in Smooth Muscle Differentiation and Proliferation
SRF and miRs in Smooth Muscle Differentiation and Proliferation1.00
3miRs in Muscle Cell Differentiation
miRs in Muscle Cell Differentiation1.00
4Adipogenesis
Adipogenesis1.00
5Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for MEF2BNB-MEF2B
    Signal transduction Calcium signaling
Immune response Function of MEF2 in T lymphocytes
Signal transduction IP3 signaling
Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
Signal transduction Activation of PKC via G-Protein coupled receptor


4 BioSystems Pathways for MEF2BNB-MEF2B 
    SRF and miRs in Smooth Muscle Differentiation and Proliferation
Adipogenesis
Energy Metabolism
miRs in Muscle Cell Differentiation



MEF2BNB-MEF2B for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MEF2BNB-MEF2B

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007507heart development ----


MEF2BNB-MEF2B for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MEF2BNB-MEF2B
Search CenterWatch for drugs/clinical trials and news about MEF2BNB-MEF2B 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MEF2BNB-MEF2B gene: 
NM_005919.3  

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000354191(uc010xqo.1) ENST00000514819

miRNA
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Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEF2BNB-MEF2B (see all 7)
OriGene shRNA RFP: MEF2BNB-MEF2B
OriGene siRNA: MEF2BNB-MEF2B
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEF2BNB-MEF2B
Clone
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEF2BNB-MEF2B (see all 4)
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Primer
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEF2BNB-MEF2B

24/245 AceView cDNA sequences (see all 245):

F05385 BM684021 AI694762 BM931564 BQ642075 AI816339 BX458898 CR598286 
BQ059304 AK057210 BQ064126 BQ680841 BQ057946 AW160805 BM804899 BG284220 
CR621883 AW161637 BI829979 BQ058774 BQ055511 BI838206 BM727433 CR624446 

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for MEF2BNB-MEF2B (see all 13)    About this scheme

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a ·
SP1:                                                              -     -           -     -     -     -     -     -           -           -                     
SP2:                                            -     -           -     -           -     -     -     -     -     -           -           -                     
SP3:                                                                                                                          -           -                     
SP4:                                                                                                                          -                                 
SP5:        -     -     -     -     -     -                       -     -           -                                                                           

ExUns: 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18
SP1:                          -     -         
SP2:                          -     -         
SP3:        -     -                           
SP4:                          -               
SP5:                                          


ECgene alternative splicing isoforms for MEF2BNB-MEF2B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MEF2BNB-MEF2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
Genevestigator expression for MEF2BNB-MEF2B
    SABiosciences Custom PCR Arrays for MEF2BNB-MEF2B
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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEF2BNB-MEF2B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MEF2BNB-MEF2B gene from 5/15 species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves MEF2BNB6
Uncharacterized protein
76(a)
1 → many
28(2674312-2683221)
zebrafish
(Danio rerio)
Actinopterygii mef2bnb6
mef2b neighbor
66(a)
1 → many
22(18390686-18399465)
fruit fly
(Drosophila melanogaster)
Insecta CG325906
--
14(a)
1 → many
X(14732295-14733164)
worm
(Caenorhabditis elegans)
Secernentea K11B4.26
Protein MEF2BNB homolog
20(a)
1 → many
I(14797649-14798703)
rice
(Oryza sativa)
Liliopsida AF141967.12   -- 78.68(n)    AF141967.1 


ENSEMBL Gene Tree for MEF2BNB-MEF2B (if available)
TreeFam Gene Tree for MEF2BNB-MEF2B (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MEF2BNB-MEF2B gene
MEF2BNB2  
1 SIMAP similar gene for MEF2BNB-MEF2B using alignment to 1 protein entry:     H3BNR1_HUMAN:
MEF2BNB

MEF2BNB-MEF2B for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/823 NCBI SNPs in MEF2BNB-MEF2B are shown (see all 823    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1855378601,2
--19255877(+) AGATCA/GCACCA 4 -- int10--------
rs746221691,2
C,--19255880(+) TCGCAA/CCACTG 4 -- int10--------
rs1162324331,2
C,F,--19255911(+) AGGGAG/ATCTCT 4 -- int11Minor allele frequency- A:0.05WA 118
rs1885061431,2
--19255987(+) TTCCAC/GCGCCC 4 -- int10--------
rs1161696871,2
F,--19256227(+) GCGTCC/GCCTGC 4 -- int11Minor allele frequency- G:0.03WA 118
rs1393480571,2
--19256459(+) GGATTA/GAGTCC 4 -- ut31 nc-transcript-variant0--------
rs22386631,2
C,F,A,H,--19256870(+) TCAGCG/AAGGAA 4 -- int1 trp323Minor allele frequency- A:0.31EA NA NS CSA 3674
rs1159357261,2
F,--19256890(+) GCCAGG/AGGATG 4 -- int11Minor allele frequency- A:0.05WA 118
rs1401557791,2
--19256925(+) AGGAGC/GACCCT 4 -- int10--------
rs1142958861,2
F,--19256927(+) GAGGAC/TCCTGG 4 -- int11Minor allele frequency- T:0.05WA 118

HapMap Linkage Disequilibrium report for MEF2BNB-MEF2B (19256376 - 19303400 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for MEF2BNB-MEF2B: --

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEF2BNB-MEF2B
DNA2.0 Custom Variant and Variant Library Synthesis for MEF2BNB-MEF2B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MEF2BNB-MEF2B for disorders           About GeneDecksing

4 diseases for MEF2BNB-MEF2B:    About MalaCards
ulcerative colitis    embryonal carcinoma    colon carcinoma    carcinoma


Export disorders for MEF2BNB-MEF2B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MEF2BNB-MEF2B gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with MEF2BNB-MEF2B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human SRF-related proteins: DNA-binding properties and potential regulatory targets. (PubMed id 1748287)1, 9 Pollock R. and Treisman R. (1991)
  2. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
  4. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
  5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
  6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1 Yerges L.M....Zmuda J.M. (2009)
  7. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
  8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
  10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S....Malek J. (2004)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4207 HGNC: 39979 AceView: MEF2B Ensembl:ENSG00000064489 euGenes: HUgn4207
ECgene: MEF2BNB-MEF2B H-InvDB: MEF2BNB-MEF2B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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