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Aliases for MEF2BNB-MEF2B Gene

Aliases for MEF2BNB-MEF2B Gene

  • MEF2BNB-MEF2B Readthrough 2 3
  • LOC729991-MEF2B Readthrough 3
  • Myocyte Enhancer Factor 2B 3
  • LOC729991-MEF2B 3
  • MEF2B 3

External Ids for MEF2BNB-MEF2B Gene

Previous GeneCards Identifiers for MEF2BNB-MEF2B Gene

  • GC19M019258

Summaries for MEF2BNB-MEF2B Gene

Entrez Gene Summary for MEF2BNB-MEF2B Gene

  • This gene represents numerous read-through transcripts that span GeneID:729991 and 100271849. Many read-through transcripts are predicted to be nonsense-mediated decay (NMD) candidates, and are thought to be non-coding. Some transcripts are predicted to be capable of translation reinitiation at a downstream AUG, resulting in expression of at least one isoform of myocyte enhancer factor 2B (MEF2B) from this read-through locus. At least one additional MEF2B variant and isoform can be expressed from a downstream promoter, and is annotated on GeneID:100271849. [provided by RefSeq, Oct 2010]

GeneCards Summary for MEF2BNB-MEF2B Gene

MEF2BNB-MEF2B (MEF2BNB-MEF2B Readthrough) is a Protein Coding gene. Among its related pathways are L1CAM interactions and Ca-dependent events. An important paralog of this gene is MEF2C.

Gene Wiki entry for MEF2BNB-MEF2B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEF2BNB-MEF2B Gene

Genomics for MEF2BNB-MEF2B Gene

Genomic Location for MEF2BNB-MEF2B Gene

Start:
19,145,567 bp from pter
End:
19,192,591 bp from pter
Size:
47,025 bases
Orientation:
Minus strand

Genomic View for MEF2BNB-MEF2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEF2BNB-MEF2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEF2BNB-MEF2B Gene

No data available for Regulatory Elements for MEF2BNB-MEF2B Gene

Proteins for MEF2BNB-MEF2B Gene

  • Protein details for MEF2BNB-MEF2B Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BNR1
    Recommended name:
    Protein MEF2BNB-MEF2B
    Protein Accession:
    H3BNR1
    Secondary Accessions:

    Protein attributes for MEF2BNB-MEF2B Gene

    Size:
    382 amino acids
    Molecular mass:
    40459 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MEF2BNB-MEF2B Gene

Proteomics data for MEF2BNB-MEF2B Gene at MOPED

Post-translational modifications for MEF2BNB-MEF2B Gene

No Post-translational modifications

Other Protein References for MEF2BNB-MEF2B Gene

No data available for DME Specific Peptides for MEF2BNB-MEF2B Gene

Domains for MEF2BNB-MEF2B Gene

Protein Domains for MEF2BNB-MEF2B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MEF2BNB-MEF2B: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MEF2BNB-MEF2B Gene

Function for MEF2BNB-MEF2B Gene

Gene Ontology (GO) - Molecular Function for MEF2BNB-MEF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with MEF2BNB-MEF2B: view

Phenotypes for MEF2BNB-MEF2B Gene

genes like me logo Genes that share phenotypes with MEF2BNB-MEF2B: view

Animal Model Products

CRISPR Products

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MEF2BNB-MEF2B
    • Block miRNA regulation of MEF2BNB-MEF2B using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for MEF2BNB-MEF2B

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MEF2BNB-MEF2B Gene

    Localization for MEF2BNB-MEF2B Gene

    Gene Ontology (GO) - Cellular Components for MEF2BNB-MEF2B Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0005634 nucleus --
    GO:0005667 transcription factor complex --
    GO:0005737 cytoplasm --
    GO:0030054 cell junction --
    genes like me logo Genes that share ontologies with MEF2BNB-MEF2B: view

    No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for MEF2BNB-MEF2B Gene

    Pathways for MEF2BNB-MEF2B Gene

    genes like me logo Genes that share pathways with MEF2BNB-MEF2B: view

    Interacting Proteins for MEF2BNB-MEF2B Gene

    STRING Interaction Network Preview (showing 4 interactants - click image to see details)
    http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000457957%0d%0a9606.ENSP00000263119%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000080059%0d%0a9606.ENSP00000340995%0d%0a
    Selected Interacting proteins: ENSP00000457957 for MEF2BNB-MEF2B Gene via STRING

    Gene Ontology (GO) - Biological Process for MEF2BNB-MEF2B Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0006351 transcription, DNA-templated --
    GO:0006355 regulation of transcription, DNA-templated --
    GO:0007507 heart development --
    GO:0007517 muscle organ development --
    GO:0045944 positive regulation of transcription from RNA polymerase II promoter --
    genes like me logo Genes that share ontologies with MEF2BNB-MEF2B: view

    Transcripts for MEF2BNB-MEF2B Gene

    CRISPR Products

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate MEF2BNB-MEF2B
      • Block miRNA regulation of MEF2BNB-MEF2B using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for MEF2BNB-MEF2B

      Primer Products

      • QuantiTect SYBR Green Assays in human,mouse,rat
      • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
      • QuantiFast Probe-based Assays in human,mouse,rat

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for MEF2BNB-MEF2B Gene

      No ASD Table

      Relevant External Links for MEF2BNB-MEF2B Gene

      GeneLoc Exon Structure for
      MEF2BNB-MEF2B
      ECgene alternative splicing isoforms for
      MEF2BNB-MEF2B

      Expression for MEF2BNB-MEF2B Gene

      mRNA expression in normal human tissues for MEF2BNB-MEF2B Gene

      genes like me logo Genes that share expressions with MEF2BNB-MEF2B: view

      In Situ Assay Products

      No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MEF2BNB-MEF2B Gene

      Orthologs for MEF2BNB-MEF2B Gene

      This gene was present in the common ancestor of eukaryotes.

      Orthologs for MEF2BNB-MEF2B Gene

      Organism Taxonomy Gene Similarity Type Details
      mouse
      (Mus musculus)
      Mammalia Mef2b 16
      oppossum
      (Monodelphis domestica)
      Mammalia -- 36
      • 55 (a)
      OneToMany
      platypus
      (Ornithorhynchus anatinus)
      Mammalia -- 36
      • 48 (a)
      OneToMany
      chicken
      (Gallus gallus)
      Aves -- 36
      • 46 (a)
      OneToMany
      rainbow trout
      (Oncorhynchus mykiss)
      Actinopterygii Omy.2586 35
      zebrafish
      (Danio rerio)
      Actinopterygii mef2b 36
      • 53 (a)
      OneToMany
      worm
      (Caenorhabditis elegans)
      Secernentea mef-2 36
      • 29 (a)
      OneToMany
      baker's yeast
      (Saccharomyces cerevisiae)
      Saccharomycetes RLM1 36
      • 10 (a)
      ManyToMany
      SMP1 36
      • 14 (a)
      ManyToMany
      corn
      (Zea mays)
      Liliopsida Zm.1104 35
      Species with no ortholog for MEF2BNB-MEF2B:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • chimpanzee (Pan troglodytes)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • cow (Bos Taurus)
      • dog (Canis familiaris)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • fruit fly (Drosophila melanogaster)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • lizard (Anolis carolinensis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • rat (Rattus norvegicus)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • tropical clawed frog (Silurana tropicalis)
      • wheat (Triticum aestivum)

      Evolution for MEF2BNB-MEF2B Gene

      ENSEMBL:
      Gene Tree for MEF2BNB-MEF2B (if available)
      TreeFam:
      Gene Tree for MEF2BNB-MEF2B (if available)

      Paralogs for MEF2BNB-MEF2B Gene

      Paralogs for MEF2BNB-MEF2B Gene

      Selected SIMAP similar genes for MEF2BNB-MEF2B Gene using alignment to 1 proteins:

      genes like me logo Genes that share paralogs with MEF2BNB-MEF2B: view

      Variants for MEF2BNB-MEF2B Gene

      Sequence variations from dbSNP and Humsavar for MEF2BNB-MEF2B Gene

      SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
      rs1134953 -- 19,176,082(-) gcctc(A/G)ctcta intron-variant
      rs2283624 -- 19,172,371(+) TCTGG(G/T)GGGCA intron-variant
      rs2283625 -- 19,172,395(+) CATGG(G/T)CTGTC intron-variant
      rs2314035 -- 19,174,111(+) AGGAG(C/T)AGGTC intron-variant
      rs3178791 -- 19,175,413(-) gtgac(A/G)gagcg intron-variant

      Structural Variations from Database of Genomic Variants (DGV) for MEF2BNB-MEF2B Gene

      Variant ID Type Subtype PubMed ID
      nsv833779 CNV Loss 17160897
      nsv911303 CNV Loss 21882294
      nsv819543 CNV Gain 19587683
      esv2718291 CNV Deletion 23290073
      esv5981 CNV Loss 19470904
      esv2677504 CNV Deletion 23128226
      esv1336135 CNV Deletion 17803354

      Relevant External Links for MEF2BNB-MEF2B Gene

      HapMap Linkage Disequilibrium report
      MEF2BNB-MEF2B

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEF2BNB-MEF2B Gene

      Disorders for MEF2BNB-MEF2B Gene

      No disorders were found for MEF2BNB-MEF2B Gene.

      No data available for UniProtKB/Swiss-Prot for MEF2BNB-MEF2B Gene

      Publications for MEF2BNB-MEF2B Gene

      1. Human SRF-related proteins: DNA-binding properties and potential regulatory targets. (PMID: 1748287) Pollock R. … Treisman R. (Genes Dev. 1991) 3 23
      2. The MEF2B homologue differentially expressed in mouse embryonal carcinoma cells. (PMID: 7646512) Hidaka K. … Mukai T. (Biochem. Biophys. Res. Commun. 1995) 23
      3. Binding of TFIID and MEF2 to the TATA element activates transcription of the Xenopus MyoDa promoter. (PMID: 8264638) Leibham D. … Perry M. (Mol. Cell. Biol. 1994) 23
      4. Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23. (PMID: 8575763) Hobson G.M. … Funanage V.L. (Genomics 1995) 23
      5. MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression. (PMID: 9430690) Katoh Y. … Periasamy M. (J. Biol. Chem. 1998) 23

      Products for MEF2BNB-MEF2B Gene

      Sources for MEF2BNB-MEF2B Gene

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