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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MEF2BNB Gene

protein-coding   GIFtS: 33
GCID: GC19M019288

MEF2B Neighbor

  Search for MEF2BNB
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MEF2B Neighbor1 2
MEF2B Neighbor Gene Protein2 3
Protein MEF2BNB2

External Ids:    HGNC: 372471   Entrez Gene: 7299912   Ensembl: ENSG000002549017   UniProtKB: Q96FH03   

Export aliases for MEF2BNB gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MEF2BNB Gene: 
MEF2BNB (MEF2B neighbor) is a protein-coding gene. GO annotations related to this gene include protein binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MEF2BNB
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MEF2BNB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEF2BNB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

MEF2BNB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEF2BNB gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M019288:  view genomic region     (about GC identifiers)

Start:
19,287,712 bp from pter      End:
19,303,400 bp from pter
Size:
15,689 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MF2NB_HUMAN, Q96FH0 (See protein sequence)
Recommended Name: Protein MEF2BNB  
Size: 119 amino acids; 13403 Da
Caution: The gene for this protein is either identical to or adjacent to that of MEF2B. Some mRNAs that encode
this protein also include MEF2B
Secondary accessions: B2RXF9 Q9BT01
Alternative splicing: 2 isoforms:  Q96FH0-1   Q96FH0-2   

Explore the universe of human proteins at neXtProt for MEF2BNB: NX_Q96FH0

Explore proteomics data for MEF2BNB at MOPED 

MEF2BNB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

MEF2BNB Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001139255.1  NP_001139256.1  

ENSEMBL proteins: 
 ENSP00000467744   ENSP00000475370   ENSP00000425864   ENSP00000467140   ENSP00000424833  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR019320 UPF0402_NEP

Graphical View of Domain Structure for InterPro Entry Q96FH0

ProtoNet protein and cluster: Q96FH0

UniProtKB/Swiss-Prot: MF2NB_HUMAN, Q96FH0
Similarity: Belongs to the MEF2BNB family


MEF2BNB for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI16189514
     
MEF2BNB for ontologies           About GeneDecksing


Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for MEF2BNB About                                                                                                See pathways by source

SuperPathContained pathways About
1AMPK signaling
AMPK signaling


1 BioSystems Pathway for MEF2BNB
    AMPK signaling


Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MEF2BNB

1 Interacting protein for MEF2BNB (Q96FH01, 3) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
TEX11Q8IYF31, 3EBI-744076,EBI-742397 I2D: score=1 
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007507heart development IEP10458488

MEF2BNB for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MEF2BNB (MF2NB)

Search CenterWatch for drugs/clinical trials and news about MEF2BNB / MF2NB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MEF2BNB gene (2 alternative transcripts): 
NM_001145783.1  NM_001145784.1  

Unigene Cluster for MEF2BNB:

MEF2B neighbor
Hs.153629  [show with all ESTs]
Unigene Representative Sequence: NR_027307
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000488252 ENST00000591566 ENST00000585679 ENST00000462790(uc002nlq.3)
ENST00000588208 ENST00000494489 ENST00000477565(uc002nlr.4) ENST00000591398
ENST00000462498(uc010ecb.2)
miRNA
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hsa-miR-182
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Inhib. RNA
Products:
     
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Clone
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEF2BNB
Sirion Biotech Customized lentivirus for stable overexpression of MEF2BNB 
                     Customized lentivirus expression plasmids for stable overexpression of MEF2BNB 
Primer
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEF2BNB

Additional mRNA sequence: 

BC000489.2 BC004449.1 BC010178.2 BC010931.1 BC073957.1 BC157837.1 BC157868.1 BC171829.1 
BC171869.1 NR_027307.1 NR_027308.1 

24/26 DOTS entries (see all 26):

DT.75121035  DT.95207373  DT.86854915  DT.97841281  DT.97844225  DT.92440753  DT.91761232  DT.92440759 
DT.101965421  DT.100774433  DT.100711167  DT.100742104  DT.121479328  DT.448293  DT.91883237  DT.95207383 
DT.95207352  DT.95207386  DT.95207387  DT.86854913  DT.100745775  DT.65288000  DT.100653602  DT.121479124 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MEF2BNB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GACCCCTAAA
MEF2BNB Expression
About this image


See MEF2BNB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MEF2BNB

SOURCE GeneReport for Unigene cluster: Hs.153629
    SABiosciences Custom PCR Arrays for MEF2BNB
Primer
Products:
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEF2BNB
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEF2BNB

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MEF2BNB gene from 5/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia 2310045N01Rik1 , 5 RIKEN cDNA 2310045N01 gene1, 5 85.99(n)1
94.96(a)1
  8 (34.15 cM)5
723681  NM_001145552.11  NP_001139024.11 
 701394995 
chicken
(Gallus gallus)
Aves MEF2BNB6
Uncharacterized protein
75(a)
1 ↔ 1
28(3342692-3351021)
zebrafish
(Danio rerio)
Actinopterygii mef2bnb1 mef2b neighbor 66.67(n)
72.65(a)
  558180  NM_001098247.2  NP_001091717.1 
fruit fly
(Drosophila melanogaster)
Insecta CG325906
--
16(a)
1 ↔ 1
X(14732295-14733164)
worm
(Caenorhabditis elegans)
Secernentea K11B4.26
Protein MEF2BNB homolog
21(a)
1 ↔ 1
I(14797660-14798714)


ENSEMBL Gene Tree for MEF2BNB (if available)
TreeFam Gene Tree for MEF2BNB (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MEF2BNB gene

MEF2BNB for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for MEF2BNB
PGOHUM00000250989


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
Structural Variations
     Database of Genomic Variants (DGV) 2 variations for MEF2BNB:    About this table     
Variant IDTypeSubtypePubMed ID
nsv833779CNV Loss17160897
nsv911303CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MEF2BNB gene integrated from 9 sources:
(articles sorted by number of sources associating them with MEF2BNB)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
  3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
  4. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  6. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
  7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  9. Expression of MEF2 genes during human cardiac development. (PubMed id 10458488)1 Iida K....Morisaki T. (1999)
  10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 729991 HGNC: 37247 Ensembl:ENSG00000254901 euGenes: HUgn729991 ECgene: MEF2BNB
H-InvDB: MEF2BNB

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MEF2BNB Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MEF2BNB gene:
Search GeneIP for patents involving MEF2BNB

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Search for Antibodies for MEF2BNB at Abcam
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 Browse SwitchGear 3'UTR luciferase reporter plasmids for MEF2BNB
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEF2BNB
 inGenious Targeting Laboratory - Custom generated mouse model solutions for MEF2BNB
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MEF2BNB
Customized:
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 lentivirus expression plasmids for stable overexpression of MEF2BNB
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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