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MEF2BNB Gene

protein-coding   GIFtS: 34
GCID: GC19M019288

MEF2B Neighbor

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disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MEF2B Neighbor1 2
MEF2B Neighbor Gene Protein2 3
Protein MEF2BNB2

External Ids:    HGNC: 372471   Entrez Gene: 7299912   Ensembl: ENSG000002549017   UniProtKB: Q96FH03   

Export aliases for MEF2BNB gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MEF2BNB Gene:
MEF2BNB (MEF2B neighbor) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MEF2BNB
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MEF2BNB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEF2BNB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

MEF2BNB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEF2BNB gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M019288:  view genomic region     (about GC identifiers)

Start:
19,287,712 bp from pter      End:
19,303,400 bp from pter
Size:
15,689 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MF2NB_HUMAN, Q96FH0 (See protein sequence)
Recommended Name: Protein MEF2BNB  
Size: 119 amino acids; 13403 Da
Caution: The gene for this protein is either identical to or adjacent to that of MEF2B. Some mRNAs that encode
this protein also include MEF2B
Secondary accessions: B2RXF9 Q9BT01
Alternative splicing: 2 isoforms:  Q96FH0-1   Q96FH0-2   

Explore the universe of human proteins at neXtProt for MEF2BNB: NX_Q96FH0

Explore proteomics data for MEF2BNB at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MEF2BNB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139255.1  NP_001139256.1  

    ENSEMBL proteins: 
     ENSP00000467744   ENSP00000475370   ENSP00000425864   ENSP00000467140   ENSP00000424833  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019320 UPF0402_NEP

    Graphical View of Domain Structure for InterPro Entry Q96FH0

    ProtoNet protein and cluster: Q96FH0

    UniProtKB/Swiss-Prot: MF2NB_HUMAN, Q96FH0
    Similarity: Belongs to the MEF2BNB family


    Find genes that share domains with MEF2BNB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with MEF2BNB           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MEF2BNB

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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      --

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MEF2BNB About    
    See pathways by source

    SuperPathContained pathways About
    1CDO in myogenesis
    CDO in myogenesis1.00
    Myogenesis1.00
    2L1CAM interactions
    Developmental Biology0.63
    3AMPK signaling
    AMPK signaling


    1 BioSystems Pathway for MEF2BNB
        AMPK signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MEF2BNB
    Interactions:

        Search GeneGlobe Interaction Network for MEF2BNB

    1 Interacting protein for MEF2BNB (Q96FH01, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TEX11Q8IYF31, 3EBI-744076,EBI-742397 I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007507heart development IEP10458488

    Find genes that share ontologies with MEF2BNB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MEF2BNB (MF2NB)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MEF2BNB gene (2 alternative transcripts): 
    NM_001145783.1  NM_001145784.1  

    Unigene Cluster for MEF2BNB:

    MEF2B neighbor
    Hs.153629  [show with all ESTs]
    Unigene Representative Sequence: NR_027307
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000488252 ENST00000591566 ENST00000585679 ENST00000462790(uc002nlq.3)
    ENST00000588208 ENST00000494489 ENST00000477565(uc002nlr.4) ENST00000591398
    ENST00000462498(uc010ecb.2)
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate MEF2BNB:
    hsa-miR-182
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    Inhib. RNA
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    Primer
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      Search QuantiTect SYBR Green Assays in human, mouse, rat MEF2BNB
      QuantiFast Probe-based Assays in human, mouse, rat MEF2BNB

    Additional mRNA sequence: 

    BC000489.2 BC004449.1 BC010178.2 BC010931.1 BC073957.1 BC157837.1 BC157868.1 BC171829.1 
    BC171869.1 NR_027307.1 NR_027308.1 

    Selected DOTS entries (see all 26):

    DT.75121035  DT.95207373  DT.86854915  DT.97841281  DT.97844225  DT.92440753  DT.91761232  DT.92440759 
    DT.101965421  DT.100774433  DT.100711167  DT.100742104  DT.121479328  DT.448293  DT.91883237  DT.95207383 
    DT.95207352  DT.95207386  DT.95207387  DT.86854913  DT.100745775  DT.65288000  DT.100653602  DT.121479124 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MEF2BNB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCCCTAAA
    MEF2BNB Expression
    About this image

    MEF2BNB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MEF2BNB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.153629
        Custom PCR Arrays for MEF2BNB
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEF2BNB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MEF2BNB gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2310045N01Rik1 , 5 RIKEN cDNA 2310045N01 gene1, 5 87.65(n)1
    98.15(a)1
      8 (34.15 cM)5
    723681  NM_001145552.11  NP_001139024.11 
     701394995 
    chicken
    (Gallus gallus)
    Aves MEF2BNB1 MEF2B neighbor 81.13(n)
    83.02(a)
      426622  NM_001256506.1  NP_001243435.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mef2bnb1 MEF2B neighbor 71.52(n)
    80.58(a)
      100490313  XM_002936328.2  XP_002936374.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mef2bnb1 mef2b neighbor 66.98(n)
    75.47(a)
      558180  NM_001098247.2  NP_001091717.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG325901 CG32590 49.14(n)
    28.87(a)
      318103  NM_167414.2  NP_727796.1 
    worm
    (Caenorhabditis elegans)
    Secernentea K11B4.26
    Protein K11B4.2 (K11B4.2) mRNA, complete cds
    21(a)
    1 ↔ 1
    I(14797660-14798714) WBGene00010767


    ENSEMBL Gene Tree for MEF2BNB (if available)
    TreeFam Gene Tree for MEF2BNB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MEF2BNB gene
    9 SIMAP similar genes for MEF2BNB using alignment to 3 protein entries:     MF2NB_HUMAN (see all proteins):
    COPS7B    RANBP3    FP1523    NDUFA7    SLC4A8    ATP6V1E1
    TBC1D22A    C19orf82    HDGFRP2

    Find genes that share paralogs with MEF2BNB           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MEF2BNB
    PGOHUM00000250989


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MEF2BNB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833779CNV Loss17160897
    nsv911303CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MEF2BNB gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with MEF2BNB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Expression of MEF2 genes during human cardiac development. (PubMed id 10458488)1 Iida K....Morisaki T. (Tohoku J. Exp. Med. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 729991 HGNC: 37247 Ensembl:ENSG00000254901 euGenes: HUgn729991 ECgene: MEF2BNB
    H-InvDB: MEF2BNB

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MEF2BNB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MEF2BNB gene:
    Search GeneIP for patents involving MEF2BNB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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