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Aliases for MEF2B Gene

Aliases for MEF2B Gene

  • Myocyte Enhancer Factor 2B 2 3
  • Serum Response Factor-Like Protein 2 3 4
  • RSRFR2 3 4
  • MADS Box Transcription Enhancer Factor 2, Polypeptide B (Myocyte Enhancer Factor 2B) 3
  • Myocyte-Specific Enhancer Factor 2B 3
  • XMEF2 4

External Ids for MEF2B Gene

Previous GeneCards Identifiers for MEF2B Gene

  • GC19M019750
  • GC19M019648
  • GC19M019101
  • GC19M019117
  • GC19M019256
  • GC19M018820

Summaries for MEF2B Gene

Entrez Gene Summary for MEF2B Gene

  • The product of this gene is a member of the MADS/MEF2 family of DNA binding proteins. The protein is thought to regulate gene expression, including expression of the smooth muscle myosin heavy chain gene. This region undergoes considerable alternative splicing, with transcripts supporting two non-overlapping loci (GeneID 729991 and 100271849) as well as numerous read-through transcripts that span both loci (annotated as GeneID 4207). Several isoforms of this protein are expressed from either this locus or from some of the read-through transcripts annotated on GeneID 4207. [provided by RefSeq, Jan 2014]

GeneCards Summary for MEF2B Gene

MEF2B (Myocyte Enhancer Factor 2B) is a Protein Coding gene. Among its related pathways are Ca-dependent events and Immune response Function of MEF2 in T lymphocytes. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and histone deacetylase binding. An important paralog of this gene is MEF2BNB-MEF2B.

UniProtKB/Swiss-Prot for MEF2B Gene

  • Transcriptional activator which binds specifically to the MEF2 element, 5-YTA[AT](4)TAR-3, found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEF2B Gene

Genomics for MEF2B Gene

Regulatory Elements for MEF2B Gene

Genomic Location for MEF2B Gene

Start:
19,145,567 bp from pter
End:
19,170,289 bp from pter
Size:
24,723 bases
Orientation:
Minus strand

Genomic View for MEF2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEF2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEF2B Gene

Proteins for MEF2B Gene

  • Protein details for MEF2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02080-MEF2B_HUMAN
    Recommended name:
    Myocyte-specific enhancer factor 2B
    Protein Accession:
    Q02080
    Secondary Accessions:
    • A0AV80
    • B4DVH7
    • B7ZVY1
    • G5E9M1

    Protein attributes for MEF2B Gene

    Size:
    365 amino acids
    Molecular mass:
    38639 Da
    Quaternary structure:
    • Interacts with HDAC7 (By similarity). Heterodimer. Interacts with HDAC9.

    Three dimensional structures from OCA and Proteopedia for MEF2B Gene

    Alternative splice isoforms for MEF2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEF2B Gene

Proteomics data for MEF2B Gene at MOPED

Post-translational modifications for MEF2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MEF2B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MEF2B Gene

Domains for MEF2B Gene

Gene Families for MEF2B Gene

HGNC:
  • MEF2 :Myocyte enhancer factors

Protein Domains for MEF2B Gene

Blocks:
InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q02080

UniProtKB/Swiss-Prot:

MEF2B_HUMAN :
  • Q02080
Domain:
  • Contains 1 MADS-box domain.
  • Contains 1 Mef2-type DNA-binding domain.
Family:
  • Belongs to the MEF2 family.
genes like me logo Genes that share domains with MEF2B: view

Function for MEF2B Gene

Molecular function for MEF2B Gene

GENATLAS Biochemistry: myocyte-specific enhancer binding factor 2B,interacting with members of the MyoD family of transcriptional activator,also interacting with TWIST to inhibit myogenesis,negatively regulated by MITR in association with HDAC1,also expressed in muscle cells
UniProtKB/Swiss-Prot Function: Transcriptional activator which binds specifically to the MEF2 element, 5-YTA[AT](4)TAR-3, found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription

Gene Ontology (GO) - Molecular Function for MEF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 7760790
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 7760790
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 8575763
GO:0042826 histone deacetylase binding IPI 15567413
genes like me logo Genes that share ontologies with MEF2B: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEF2B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MEF2B Gene

Localization for MEF2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEF2B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEF2B Gene COMPARTMENTS Subcellular localization image for MEF2B gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 2

Gene Ontology (GO) - Cellular Components for MEF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005667 transcription factor complex IDA 15567413
GO:0005737 cytoplasm IDA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with MEF2B: view

Pathways for MEF2B Gene

genes like me logo Genes that share pathways with MEF2B: view

Interacting Proteins for MEF2B Gene

Selected Interacting proteins: Q02080-MEF2B_HUMAN for MEF2B Gene via I2D

Gene Ontology (GO) - Biological Process for MEF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007517 muscle organ development TAS 1516833
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 7760790
genes like me logo Genes that share ontologies with MEF2B: view

Transcripts for MEF2B Gene

mRNA/cDNA for MEF2B Gene

(1) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEF2B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MEF2B
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEF2B Gene

No ASD Table

Relevant External Links for MEF2B Gene

GeneLoc Exon Structure for
MEF2B
ECgene alternative splicing isoforms for
MEF2B

Expression for MEF2B Gene

mRNA expression in normal human tissues for MEF2B Gene

mRNA differential expression in normal tissues according to GTEx for MEF2B Gene

This gene is overexpressed in Whole Blood (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MEF2B Gene

mRNA Expression by UniProt/SwissProt for MEF2B Gene

Q02080-MEF2B_HUMAN
Tissue specificity: Expressed in skeletal and cardiac muscle and brain
genes like me logo Genes that share expressions with MEF2B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MEF2B Gene

Orthologs for MEF2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MEF2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEF2B 35
  • 99.73 (n)
  • 99.46 (a)
MEF2B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MEF2B 35
  • 87.05 (n)
  • 90.22 (a)
MEF2B 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEF2B 35
  • 83.42 (n)
  • 83.15 (a)
MEF2B 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2310045N01Rik 36
  • 72 (a)
OneToMany
Mef2b 35
  • 75.19 (n)
  • 72.13 (a)
Mef2b 36
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mef2b 35
  • 74.37 (n)
  • 71.97 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 54 (a)
OneToMany
MEF2B 35
  • 65.9 (n)
  • 60.98 (a)
zebrafish
(Danio rerio)
Actinopterygii mef2b 35
  • 55.02 (n)
  • 51.6 (a)
mef2b 36
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mef-2 36
  • 32 (a)
OneToMany
mef-2 37
  • 78 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RLM1 36
  • 11 (a)
ManyToMany
SMP1 36
  • 14 (a)
ManyToMany
Species with no ortholog for MEF2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MEF2B Gene

ENSEMBL:
Gene Tree for MEF2B (if available)
TreeFam:
Gene Tree for MEF2B (if available)

Paralogs for MEF2B Gene

Paralogs for MEF2B Gene

Selected SIMAP similar genes for MEF2B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MEF2B: view

Variants for MEF2B Gene

Structural Variations from Database of Genomic Variants (DGV) for MEF2B Gene

Variant ID Type Subtype PubMed ID
nsv833779 CNV Loss 17160897
nsv911303 CNV Loss 21882294
nsv819543 CNV Gain 19587683
esv2718291 CNV Deletion 23290073
esv5981 CNV Loss 19470904
esv2677504 CNV Deletion 23128226
esv1336135 CNV Deletion 17803354

Relevant External Links for MEF2B Gene

HapMap Linkage Disequilibrium report
MEF2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MEF2B Gene

Disorders for MEF2B Gene

Relevant External Links for MEF2B

Genetic Association Database (GAD)
MEF2B
Human Genome Epidemiology (HuGE) Navigator
MEF2B
genes like me logo Genes that share disorders with MEF2B: view

No data available for UniProtKB/Swiss-Prot for MEF2B Gene

Publications for MEF2B Gene

  1. Human myocyte-specific enhancer factor 2 comprises a group of tissue- restricted MADS box transcription factors. (PMID: 1516833) Yu Y.-T. … Nadal-Ginard B. (Genes Dev. 1992) 2 3 4
  2. Human SRF-related proteins: DNA-binding properties and potential regulatory targets. (PMID: 1748287) Pollock R. … Treisman R. (Genes Dev. 1991) 3 4
  3. Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2. (PMID: 12700764) Han A. … Chen L. (Nature 2003) 3 4
  4. Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23. (PMID: 8575763) Hobson G.M. … Funanage V.L. (Genomics 1995) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MEF2B Gene

Sources for MEF2B Gene

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