MEF2B Gene
protein-coding GIFtS: 44
GCID: GC19M019256
|
|
myocyte enhancer factor 2B
| |
Aliases
for MEF2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Myocyte Enhancer Factor 2B1 2 | | RSRFR21 2 3 | | Serum Response Factor-Like Protein 22 3 | | MADS Box Transcription Enhancer Factor 2, Polypeptide B (Myocyte EnhancerFactor 2B)2 | | Myocyte-Specific Enhancer Factor 2B2 | | XMEF23 |
| External Ids: | HGNC: 69951 | Entrez Gene: 1002718492 | Ensembl: ENSG000002139997 | OMIM: 6006615 | UniProtKB: Q020803 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n335704 n407781 | |
Export aliases for MEF2B gene to outside databasesPrevious GC identifers: GC19M019750 GC19M019648 GC19M019101 GC19M019117 GC19M018820
Summaries
for MEF2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MEF2B:
The product of this gene is a member of the MADS/MEF2 family of DNA binding proteins. The protein is thought toregulate gene expression, including expression of the smooth muscle myosin heavy chain gene. This region undergoesconsiderable alternative splicing, with transcripts supporting two non-overlapping loci (geneID:729991 and 100271849)as well as numerous read-through transcripts that span both loci (annotated as geneID:4207). Several isoforms of thisprotein are expressed from either this locus or from some of the read-through transcripts annotated on geneID:4207.(provided by RefSeq, Mar 2009)
UniProtKB/Swiss-Prot: MEF2B_HUMAN, Q02080Function: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found innumerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/orgrowth factor-related transcription
|
Genomic Views
for MEF2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MEF2B gene promoter:
MIF-1 AP-2gamma AREB6 CREB POU2F1 POU2F1a SEF-1 (1) Ik-1 ATF6 Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for MEF2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEF2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.11MEF2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M019256: view genomic region
(about GC identifiers)
Start:
|
19,256,376 bp from pter |
End:
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19,303,400 bp from pter |
Size:
|
47,025 bases |
Orientation:
|
minus strand |
ORGUL member locations:
Legend (see complete legend)
19256375 19279888 19303400 chr19
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Proteins
for MEF2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MEF2B_HUMAN, Q02080 (See
protein sequence)Recommended Name: Myocyte-specific enhancer factor 2B Size: 365 amino acids; 38639 Da
Subunit: Interacts with HDAC7 (By similarity). Heterodimer. Interacts with HDAC9
Subcellular location: Nucleus
2 PDB 3D structures from  and Proteopedia  for MEF2B:1N6J (3D)
1TQE (3D)
Secondary accessions: A0AV80 B4DVH7 B7ZVY1 G5E9M1Alternative splicing: 2 isoforms: Q02080-1 Q02080-2 Explore the universe of human proteins at neXtProt for MEF2B: NX_Q02080
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q02080
MEF2B Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001139257.1
ENSEMBL proteins: ENSP00000386480 ENSP00000402154 ENSP00000386374 ENSP00000386784 ENSP00000390762 ENSP00000162023 Reactome Protein details: Q02080
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MEF2B for ontologies About GeneDecksing
MEF2B Antibody Products:
Assay Products for MEF2B: |
Protein
Domains /
Families
for MEF2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MEF2B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q02080ProtoNet protein and cluster: Q02080 1 Blocks protein family: IPB002100 Transcription factor
UniProtKB/Swiss-Prot: MEF2B_HUMAN, Q02080Similarity: Belongs to the MEF2 familySimilarity: Contains 1 MADS-box domainSimilarity: Contains 1 Mef2-type DNA-binding domain |
Function
for MEF2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MEF2B_HUMAN, Q02080Function: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found innumerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/orgrowth factor-related transcription Genatlas biochemistry entry for MEF2B:myocyte-specific enhancer binding factor 2B,interacting with members of the MyoD family of transcriptionalactivator,also interacting with TWIST to inhibit myogenesis,negatively regulated by MITR in association withHDAC1,also expressed in muscle cells
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEF2B
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEF2B |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
MEF2B for ontologies About GeneDecksing
|
Pathways & Interactions
for MEF2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Activation of p38 alpha/beta MAPK | | | 2 | Immune response_Function of MEF2 in T lymphocytes | | | 3 | Signal transduction_Activation of PKC via G-Protein coupled receptor | | | 4 | SRF and miRs in Smooth Muscle Differentiation and Proliferation | | | 5 | miRs in Muscle Cell Differentiation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5  GeneGo (Thomson Reuters) Pathways for MEF2B
4  BioSystems Pathways for MEF2B
3 
Reactome Pathways for MEF2B
MEF2B for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MEF2B
4 Interacting proteins for MEF2B (Q020803) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0007517 | muscle organ development |
TAS | 1516833 |
MEF2B for ontologies About GeneDecksing
|
Drugs & Compounds
for MEF2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MEF2B
Search CenterWatch for drugs/clinical trials and news about MEF2B
|
Transcripts
for MEF2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MEF2B gene: NM_001145785.1 7 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000409224(uc002nll.2 uc002nlk.2) ENST00000424583 ENST00000410050
ENST00000409447 ENST00000475290 ENST00000444486(uc010xqp.1 uc002nlo.2 uc002nlp.2)
ENST00000162023
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEF2B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEF2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MEF2B (NM_005919) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MEF2B | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MEF2B |
GeneLoc Exon Structure
|
Expression
for MEF2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MEF2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
Genevestigator expression for MEF2B
UniProtKB/Swiss-Prot: MEF2B_HUMAN, Q02080Tissue specificity: Expressed in skeletal and cardiac muscle and brain
SABiosciences Custom PCR Arrays for MEF2B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEF2B
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MEF2B | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEF2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEF2B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEF2B |
Orthologs
for MEF2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MEF2B gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for MEF2B (if available)
TreeFam Gene Tree for MEF2B (if available) |
Paralogs
for MEF2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MEF2B gene
- MEF2D2 MEF2C2 MEF2A2
4 SIMAP similar genes for MEF2B using alignment to 4 protein entries: MEF2B_HUMAN (see all proteins):MEF2A MEF2D MEF2C MEF2D variant protein
MEF2B for paralogs About GeneDecksing
|
Genomic Variants
for MEF2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for MEF2B
1 CNV: 58864
2 Indels: 61679 26207 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEF2B |
|
Disorders
/ Diseases
for MEF2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MEF2B for disorders About GeneDecksing
OMIM gene information: 600661
OMIM disorders: --
1  disease for MEF2B: About MalaCardsneuronitis
Human Genome Epidemiology (HuGE) Navigator: MEF2B (6 documents)
Export disorders for MEF2B gene to outside databases
|
Publications
for MEF2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MEF2B gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with MEF2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human myocyte-specific enhancer factor 2 comprises a group of tissue- restricted MADS box transcription factors. (PubMed id 1516833)1, 2, 3 Yu Y.-T....Nadal-Ginard B. (1992)
- Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2. (PubMed id 15567413)1, 2 Han A.... Chen L. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2. (PubMed id 12700764)1, 2 Han A.... Chen L. (2003)
- Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23. (PubMed id 8575763)1, 3 Hobson G.M....Funanage V.L. (1995)
- Human SRF-related proteins: DNA-binding properties and potential regulatory targets. (PubMed id 1748287)1, 2 Pollock R. and Treisman R. (1991)
- Role of myocyte enhancing factor 2B in epithelial myof ibroblast transition of human gingival keratinocytes. (PubMed id 22302709)1 Sun Q....Chamulitrat W. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
|
External Searches for MEF2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MEF2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MEF2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MEF2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MEF2B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MEF2B gene:
Search GeneIP for patents involving MEF2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MEF2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | | Search Tocris compounds for MEF2B |
| |  |  |  |  | | | | |
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 | | | MEF2B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEF2B |
|  |  |  | | | | Search ThermoFisher Antibodies for MEF2B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MEF2B |
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