Aliases for MEF2A Gene
External Ids for MEF2A Gene
Previous GeneCards Identifiers for MEF2A Gene
The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
GeneCards Summary for MEF2A Gene
MEF2A (Myocyte Enhancer Factor 2A) is a Protein Coding gene. Diseases associated with MEF2A include Coronary Artery Disease, Autosomal Dominant, 1 and Mef2a-Related Coronary Artery Disease Susceptibility. Among its related pathways are Signaling mediated by p38-alpha and p38-beta and Phospholipase-C Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is MEF2D.
UniProtKB/Swiss-Prot for MEF2A Gene
Transcriptional activator which binds specifically to the MEF2 element, 5-YTA[AT](4)TAR-3, found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.