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MEDAG Gene

protein-coding   GIFtS: 35
GCID: GC13P031481

Mesenteric Estrogen-Dependent Adipogenesis

(Previous name: chromosome 13 open reading frame 33)
(Previous symbol: C13orf33)
  Search for MEDAG
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mesenteric Estrogen-Dependent Adipogenesis1 2     MEDA-42 3
C13orf331 2 3     MEDA42 3
Activated In W/Wv Mouse Stomach 3 Homolog1 2 3     hAWMS32 3
Mesenteric Estrogen-Dependent Adipose 41 2 3     Chromosome 13 Open Reading Frame 331
AWMS32 3     Mesenteric Estrogen-Dependent Adipogenesis Protein2

External Ids:    HGNC: 259261   Entrez Gene: 849352   Ensembl: ENSG000001028027   UniProtKB: Q5VYS43   

Export aliases for MEDAG gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MEDAG Gene:
MEDAG (mesenteric estrogen-dependent adipogenesis) is a protein-coding gene.

UniProtKB/Swiss-Prot: MEDAG_HUMAN, Q5VYS4
Function: Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in
mature adipocytes (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_024524.15  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MEDAG
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEDAG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.3   Ensembl cytogenetic band:  13q12.3   HGNC cytogenetic band: 13q12.3

MEDAG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEDAG gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P031481:  view genomic region     (about GC identifiers)

Start:
31,480,312 bp from pter      End:
31,499,709 bp from pter
Size:
19,398 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MEDAG_HUMAN, Q5VYS4 (See protein sequence)
Recommended Name: Mesenteric estrogen-dependent adipogenesis protein  
Size: 303 amino acids; 34190 Da
Secondary accessions: Q8IXF1 Q96K26 Q96NC8
Alternative splicing: 2 isoforms:  Q5VYS4-1   Q5VYS4-2   

Explore the universe of human proteins at neXtProt for MEDAG: NX_Q5VYS4

Explore proteomics data for MEDAG at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MEDAG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116238.2  
    ENSEMBL proteins: 
     ENSP00000369849   ENSP00000416838  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q5VYS4


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MEDAG_HUMAN, Q5VYS4
    Function: Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in
    mature adipocytes (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for MEDAG:

     Increased G2M DNA content 

         1 MGI phenotypic allele for Medag (no phenotypes)

    MEDAG for phenotypes           About GeneDecksing

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MEDAG_HUMAN, Q5VYS4: Cytoplasm

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--

    MEDAG for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MEDAG
    Interactions:

        Search GeneGlobe Interaction Network for MEDAG

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for MEDAG (Q5VYS43 ENSP000003698494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF6Q9Y4K33I2D: score=1 
    --ENSP000003168404STRING: ENSP00000316840
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045600positive regulation of fat cell differentiation ISS--

    MEDAG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for MEDAG



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MEDAG gene: 
    NM_032849.3  

    Unigene Cluster for MEDAG:

    Mesenteric estrogen-dependent adipogenesis
    Hs.147880  [show with all ESTs]
    Unigene Representative Sequence: NM_032849
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380482(uc001uth.4) ENST00000428944
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    Additional mRNA sequence: 

    AB055407.1 AK055635.1 AL832478.1 BC040165.1 BC101624.1 BC101626.1 

    3 DOTS entries:

    DT.100839594  DT.428287  DT.212831 

    Selected AceView cDNA sequences (see all 82):

    AA372843 AW627754 BX107995 AI335021 AW593561 AA514237 BM725076 AI249343 
    AI867990 AA046037 AI192210 AI918566 AA962462 BQ003769 BC040165 AI151412 
    AW631066 AW513998 NM_032849 AA296399 AA868187 BG199438 AA131311 BU146394 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MEDAG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MEDAG Expression
    About this image


    MEDAG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor
     
     Neural Tube (Nervous System)
             Metencephalon
    MEDAG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MEDAG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.147880

    UniProtKB/Swiss-Prot: MEDAG_HUMAN, Q5VYS4
    Tissue specificity: Highly expressed in the visceral fat depot

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MEDAG gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Medag1 , 5 RIKEN cDNA 6330406I15 gene5
    mesenteric estrogen dependent adipogenesis1
    86.25(n)1
    91.42(a)1
      5 (89.18 cM)5
    707171  NM_027519.31  NP_081795.11 
     1494117495 
    lizard
    (Anolis carolinensis)
    Reptilia MEDAG6
    mesenteric estrogen-dependent adipogenesis
    60(a)
    1 ↔ 1
    3(184432588-184451080)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia medag1 mesenteric estrogen-dependent adipogenesis 56.49(n)
    45.38(a)
      100170487  XM_004912038.1  XP_004912095.1 


    ENSEMBL Gene Tree for MEDAG (if available)
    TreeFam Gene Tree for MEDAG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for MEDAG    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs95319451,2,4
    ----see VAR_0302612 mis40--------

    HapMap Linkage Disequilibrium report for MEDAG (31480312 - 31499709 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MEDAG: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MEDAG
    DNA2.0 Custom Variant and Variant Library Synthesis for MEDAG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MEDAG gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MEDAG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel genes of visceral adiposity: identification of mouse and human mesenteric estrogen-dependent adipose (MEDA)-4 gene and its adipogenic function. (PubMed id 22510272)1, 2, 3 Zhang H.... Sairam M.R. (Endocrinology 2012)
    2. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84935 HGNC: 25926 AceView: FLJ14834 Ensembl:ENSG00000102802 euGenes: HUgn84935
    ECgene: MEDAG H-InvDB: MEDAG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MEDAG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MEDAG gene:
    Search GeneIP for patents involving MEDAG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     SwitchGear 3'UTR luciferase reporter plasmids for MEDAG
     Browse SwitchGear Promoter luciferase reporter plasmids for MEDAG
     ThermoFisher Antibodies for MEDAG
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEDAG
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MEDAG
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MEDAG
     LSBio Antibodies in human, mouse, rat for MEDAG
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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