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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MEDAG Gene

protein-coding   GIFtS: 36
GCID: GC13P031481

Mesenteric Estrogen-Dependent Adipogenesis

(Previous name: chromosome 13 open reading frame 33)
(Previous symbol: C13orf33)
  Search for MEDAG
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mesenteric Estrogen-Dependent Adipogenesis1 2     MEDA-42 3
C13orf331 2 3     MEDA42 3
Activated In W/Wv Mouse Stomach 3 Homolog1 2 3     hAWMS32 3
Mesenteric Estrogen-Dependent Adipose 41 2 3     Chromosome 13 Open Reading Frame 331
AWMS32 3     Mesenteric Estrogen-Dependent Adipogenesis Protein2

External Ids:    HGNC: 259261   Entrez Gene: 849352   Ensembl: ENSG000001028027   UniProtKB: Q5VYS43   

Export aliases for MEDAG gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MEDAG Gene: 
MEDAG (mesenteric estrogen-dependent adipogenesis) is a protein-coding gene.

UniProtKB/Swiss-Prot: MEDAG_HUMAN, Q5VYS4
Function: Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in
mature adipocytes (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_024524.14  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MEDAG
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MEDAG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEDAG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.3   Ensembl cytogenetic band:  13q12.3   HGNC cytogenetic band: 13q12.3

MEDAG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEDAG gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P031481:  view genomic region     (about GC identifiers)

Start:
31,480,312 bp from pter      End:
31,499,709 bp from pter
Size:
19,398 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: MEDAG_HUMAN, Q5VYS4 (See protein sequence)
Recommended Name: Mesenteric estrogen-dependent adipogenesis protein  
Size: 303 amino acids; 34190 Da
Subcellular location: Cytoplasm
Secondary accessions: Q8IXF1 Q96K26 Q96NC8
Alternative splicing: 2 isoforms:  Q5VYS4-1   Q5VYS4-2   

Explore the universe of human proteins at neXtProt for MEDAG: NX_Q5VYS4

Explore proteomics data for MEDAG at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5VYS4

  • MEDAG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MEDAG Protein Expression
    REFSEQ proteins: NP_116238.2  
    ENSEMBL proteins: 
     ENSP00000369849   ENSP00000416838  

    Human Recombinant Protein Products for MEDAG: 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--

    MEDAG for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q5VYS4


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MEDAG_HUMAN, Q5VYS4
    Function: Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in
    mature adipocytes (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for MEDAG:

     Increased G2M DNA content 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MEDAG

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for MEDAG (Q5VYS43 ENSP000003698494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF6Q9Y4K33I2D: score=1 
    --ENSP000003168404STRING: ENSP00000316840
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045600positive regulation of fat cell differentiation ISS--

    MEDAG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MEDAG

    Search CenterWatch for drugs/clinical trials and news about MEDAG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for MEDAG gene: 
    NM_032849.3  

    Unigene Clusters for MEDAG:

    Mesenteric estrogen-dependent adipogenesis
    Hs.147880  [show with all ESTs], Hs.708377  [show with all ESTs]
    Unigene Representative Sequences: NM_032849, AK027740
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380482(uc001uth.4) ENST00000428944
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    Additional mRNA sequence: AK027740.1 

    3 DOTS entries:

    DT.100839594  DT.212831  DT.428287 

    24/82 AceView cDNA sequences (see all 82):

    AA046037 AI918566 AA372843 AI249343 AI867990 BC040165 AI335021 BX107995 
    AA962462 BQ003769 AW593561 BM725076 AI151412 AW627754 AA514237 AI192210 
    BX378017 BQ942507 NM_032849 AI077657 AA046129 AA868187 AA476867 AK055635 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MEDAG expression in normal human tissues (normalized intensities)      MEDAG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MEDAG Expression
    About this image


    MEDAG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem progenitor F15
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Endothelium (Cardiovascular System)
             Peripheral blood-derived endothelial progenitor cells
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor

    See MEDAG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MEDAG

    SOURCE GeneReport for Unigene clusters: Hs.147880 Hs.708377

    UniProtKB/Swiss-Prot: MEDAG_HUMAN, Q5VYS4
    Tissue specificity: Highly expressed in the visceral fat depot

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEDAG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MEDAG gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Medag1 , 5 RIKEN cDNA 6330406I15 gene5
    mesenteric estrogen dependent adipogenesis1
    86.25(n)1
    91.42(a)1
      5 (89.18 cM)5
    707171  NM_027519.31  NP_081795.11 
     1493684765 
    lizard
    (Anolis carolinensis)
    Reptilia C13ORF336
    Uncharacterized protein
    61(a)
    1 ↔ 1
    3(184432588-184451080)


    ENSEMBL Gene Tree for MEDAG (if available)
    TreeFam Gene Tree for MEDAG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in MEDAG are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0302614
    ----see VAR_0302612 R G mis40--------

    HapMap Linkage Disequilibrium report for MEDAG (31480312 - 31499709 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MEDAG: --
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MEDAG gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MEDAG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel genes of visceral adiposity: identification of m ouse and human mesenteric estrogen-dependent adipose (MEDA)-4 gene and its adipo genic function. (PubMed id 22510272)1, 2, 3 Zhang H....Sairam M.R. (2012)
    2. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84935 HGNC: 25926 AceView: FLJ14834 Ensembl:ENSG00000102802 euGenes: HUgn84935
    ECgene: MEDAG H-InvDB: MEDAG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MEDAG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MEDAG gene:
    Search GeneIP for patents involving MEDAG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for MEDAG
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEDAG
     SwitchGear 3'UTR luciferase reporter plasmids for MEDAG
     Browse SwitchGear Promoter luciferase reporter plasmids for MEDAG
     ThermoFisher Antibodies for MEDAG
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEDAG
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MEDAG
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MEDAG
    Customized:
     lentivirus for stable overexpression of MEDAG
     lentivirus expression plasmids for stable overexpression of MEDAG
     adenovirus for overexpression of MEDAG
     LSBio Antibodies in human, mouse, rat for MEDAG
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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