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Aliases for MEDAG Gene

Aliases for MEDAG Gene

  • Mesenteric Estrogen Dependent Adipogenesis 2 3 5
  • Activated In W/Wv Mouse Stomach 3 Homolog 2 3 4
  • Mesenteric Estrogen-Dependent Adipose 4 2 3 4
  • C13orf33 3 4
  • MEDA-4 3 4
  • HAWMS3 3 4
  • AWMS3 3 4
  • MEDA4 3 4
  • Mesenteric Estrogen-Dependent Adipogenesis Protein 3
  • Mesenteric Estrogen-Dependent Adipogenesis 2
  • Chromosome 13 Open Reading Frame 33 2

External Ids for MEDAG Gene

Previous HGNC Symbols for MEDAG Gene

  • C13orf33

Previous GeneCards Identifiers for MEDAG Gene

  • GC13P031481

Summaries for MEDAG Gene

GeneCards Summary for MEDAG Gene

MEDAG (Mesenteric Estrogen Dependent Adipogenesis) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MEDAG Gene

  • Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes.

Additional gene information for MEDAG Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEDAG Gene

Genomics for MEDAG Gene

GeneHancer (GH) Regulatory Elements for MEDAG Gene

Promoters and enhancers for MEDAG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I030905 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 567.2 +0.7 731 2.5 FOXA2 POLR2A ZIC2 EZH2 MEDAG TEX26-AS1 TEX26
GH13I030904 Enhancer 0.4 FANTOM5 dbSUPER 556 -1.9 -1889 0.3 MEDAG LINC00545 TEX26-AS1
GH13I030897 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 18.6 -7.0 -7010 2.5 ELF3 SAP130 JUN MAX ZNF644 RARA TEAD3 POLR2A FOS MIXL1 MEDAG LINC00545 TEX26-AS1
GH13I030862 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15.2 -41.2 -41163 5.2 PKNOX1 ATF1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF48 YY1 TEX26 MEDAG TEX26-AS1 RXFP2 LINC00545 PIR60604
GH13I030879 Enhancer 0.9 Ensembl ENCODE dbSUPER 27 -24.8 -24770 3.8 JUND FOS ZNF48 NR2F2 LINC00545 MEDAG TEX26-AS1 TEX26 LOC105370145 PIR60604
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MEDAG on UCSC Golden Path with GeneCards custom track

Genomic Locations for MEDAG Gene

Genomic Locations for MEDAG Gene
chr13:30,906,175-30,925,572
(GRCh38/hg38)
Size:
19,398 bases
Orientation:
Plus strand
chr13:31,480,312-31,499,709
(GRCh37/hg19)

Genomic View for MEDAG Gene

Genes around MEDAG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEDAG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEDAG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEDAG Gene

Proteins for MEDAG Gene

  • Protein details for MEDAG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VYS4-MEDAG_HUMAN
    Recommended name:
    Mesenteric estrogen-dependent adipogenesis protein
    Protein Accession:
    Q5VYS4
    Secondary Accessions:
    • Q8IXF1
    • Q96K26
    • Q96NC8

    Protein attributes for MEDAG Gene

    Size:
    303 amino acids
    Molecular mass:
    34190 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MEDAG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEDAG Gene

Post-translational modifications for MEDAG Gene

No Post-translational modifications

Other Protein References for MEDAG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEDAG Gene

Domains & Families for MEDAG Gene

Gene Families for MEDAG Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MEDAG Gene

ProtoNet:

Suggested Antigen Peptide Sequences for MEDAG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MEDAG: view

No data available for UniProtKB/Swiss-Prot for MEDAG Gene

Function for MEDAG Gene

Molecular function for MEDAG Gene

UniProtKB/Swiss-Prot Function:
Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes.

Phenotypes From GWAS Catalog for MEDAG Gene

genes like me logo Genes that share phenotypes with MEDAG: view

Animal Models for MEDAG Gene

MGI Knock Outs for MEDAG:

Animal Model Products

CRISPR Products

miRNA for MEDAG Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEDAG Gene

Localization for MEDAG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEDAG Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEDAG gene
Compartment Confidence
nucleus 3
peroxisome 2
cytosol 2

Gene Ontology (GO) - Cellular Components for MEDAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22510272
genes like me logo Genes that share ontologies with MEDAG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MEDAG Gene

Pathways & Interactions for MEDAG Gene

SuperPathways for MEDAG Gene

No Data Available

Interacting Proteins for MEDAG Gene

Selected Interacting proteins: Q5VYS4-MEDAG_HUMAN for MEDAG Gene via IID

Symbol External ID(s) Details
TRAF6

Gene Ontology (GO) - Biological Process for MEDAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045600 positive regulation of fat cell differentiation IEA,ISS --
genes like me logo Genes that share ontologies with MEDAG: view

No data available for Pathways by source and SIGNOR curated interactions for MEDAG Gene

Drugs & Compounds for MEDAG Gene

No Compound Related Data Available

Transcripts for MEDAG Gene

mRNA/cDNA for MEDAG Gene

Unigene Clusters for MEDAG Gene

Mesenteric estrogen-dependent adipogenesis:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEDAG Gene

No ASD Table

Relevant External Links for MEDAG Gene

GeneLoc Exon Structure for
MEDAG
ECgene alternative splicing isoforms for
MEDAG

Expression for MEDAG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEDAG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEDAG Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x7.3), Artery - Aorta (x6.6), Artery - Tibial (x5.3), and Artery - Coronary (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of MEDAG Gene:

MEDAG

SOURCE GeneReport for Unigene cluster for MEDAG Gene:

Hs.147880

mRNA Expression by UniProt/SwissProt for MEDAG Gene:

Q5VYS4-MEDAG_HUMAN
Tissue specificity: Highly expressed in the visceral fat depot.

Evidence on tissue expression from TISSUES for MEDAG Gene

  • Heart(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with MEDAG: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEDAG Gene

Orthologs for MEDAG Gene

This gene was present in the common ancestor of chordates.

Orthologs for MEDAG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEDAG 33 34
  • 99.23 (n)
dog
(Canis familiaris)
Mammalia MEDAG 33 34
  • 91.81 (n)
cow
(Bos Taurus)
Mammalia MEDAG 33 34
  • 90.1 (n)
rat
(Rattus norvegicus)
Mammalia Medag 33
  • 86.27 (n)
mouse
(Mus musculus)
Mammalia Medag 33 16 34
  • 86.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MEDAG 34
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MEDAG 34
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEDAG 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia medag 33
  • 56.49 (n)
Species where no ortholog for MEDAG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MEDAG Gene

ENSEMBL:
Gene Tree for MEDAG (if available)
TreeFam:
Gene Tree for MEDAG (if available)

Paralogs for MEDAG Gene

No data available for Paralogs for MEDAG Gene

Variants for MEDAG Gene

Sequence variations from dbSNP and Humsavar for MEDAG Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000087172 -- 30,917,593(+) A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000132803 -- 30,906,453(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000246387 -- 30,912,304(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000442227 -- 30,910,473(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000457433 -- 30,904,190(+) C/G/T upstream_transcript_variant

Variation tolerance for MEDAG Gene

Residual Variation Intolerance Score: 51.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.35; 63.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEDAG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEDAG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MEDAG Gene

Disorders for MEDAG Gene

Additional Disease Information for MEDAG

No disorders were found for MEDAG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEDAG Gene

Publications for MEDAG Gene

  1. Novel genes of visceral adiposity: identification of mouse and human mesenteric estrogen-dependent adipose (MEDA)-4 gene and its adipogenic function. (PMID: 22510272) Zhang H … Sairam MR (Endocrinology 2012) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Human gingiva transcriptome during wound healing. (PMID: 28005267) Wang Y … Tatakis DN (Journal of clinical periodontology 2017) 3 58

Products for MEDAG Gene

Sources for MEDAG Gene

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