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Aliases for MEDAG Gene

Aliases for MEDAG Gene

  • Mesenteric Estrogen-Dependent Adipogenesis 2 3
  • Activated In W/Wv Mouse Stomach 3 Homolog 2 3 4
  • Mesenteric Estrogen-Dependent Adipose 4 2 3 4
  • C13orf33 3 4
  • MEDA-4 3 4
  • HAWMS3 3 4
  • AWMS3 3 4
  • MEDA4 3 4
  • Mesenteric Estrogen-Dependent Adipogenesis Protein 3
  • Chromosome 13 Open Reading Frame 33 2

External Ids for MEDAG Gene

Previous Symbols for MEDAG Gene

  • C13orf33

Summaries for MEDAG Gene

GeneCards Summary for MEDAG Gene

MEDAG (Mesenteric Estrogen-Dependent Adipogenesis) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MEDAG Gene

  • Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEDAG Gene

Genomics for MEDAG Gene

Genomic Location for MEDAG Gene

Start:
30,906,175 bp from pter
End:
30,925,572 bp from pter
Size:
19,398 bases
Orientation:
Plus strand

Genomic View for MEDAG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEDAG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEDAG Gene

No data available for Regulatory Elements for MEDAG Gene

Proteins for MEDAG Gene

  • Protein details for MEDAG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VYS4-MEDAG_HUMAN
    Recommended name:
    Mesenteric estrogen-dependent adipogenesis protein
    Protein Accession:
    Q5VYS4
    Secondary Accessions:
    • Q8IXF1
    • Q96K26
    • Q96NC8

    Protein attributes for MEDAG Gene

    Size:
    303 amino acids
    Molecular mass:
    34190 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MEDAG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEDAG Gene

Proteomics data for MEDAG Gene at MOPED

Post-translational modifications for MEDAG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MEDAG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEDAG Gene

Domains for MEDAG Gene

Protein Domains for MEDAG Gene

ProtoNet:
genes like me logo Genes that share domains with MEDAG: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MEDAG Gene

Function for MEDAG Gene

Molecular function for MEDAG Gene

UniProtKB/Swiss-Prot Function: Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes.

Phenotypes for MEDAG Gene

GenomeRNAi human phenotypes for MEDAG:
genes like me logo Genes that share phenotypes with MEDAG: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MEDAG Gene

Localization for MEDAG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEDAG Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for MEDAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22510272
genes like me logo Genes that share ontologies with MEDAG: view

Pathways for MEDAG Gene

SuperPathways for MEDAG Gene

No Data Available

Interacting Proteins for MEDAG Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000369849%0d%0a9606.ENSP00000337853%0d%0a
Selected Interacting proteins: ENSP00000369849 Q5VYS4-MEDAG_HUMAN for MEDAG Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MEDAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045600 positive regulation of fat cell differentiation ISS --
genes like me logo Genes that share ontologies with MEDAG: view

No data available for Pathways by source for MEDAG Gene

Transcripts for MEDAG Gene

mRNA/cDNA for MEDAG Gene

Unigene Clusters for MEDAG Gene

Mesenteric estrogen-dependent adipogenesis:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEDAG Gene

No ASD Table

Relevant External Links for MEDAG Gene

GeneLoc Exon Structure for
MEDAG
ECgene alternative splicing isoforms for
MEDAG

Expression for MEDAG Gene

mRNA expression in normal human tissues for MEDAG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEDAG Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (7.3), Artery - Aorta (6.6), Artery - Tibial (5.3), and Artery - Coronary (4.3).

SOURCE GeneReport for Unigene cluster for MEDAG Gene Hs.147880

mRNA Expression by UniProt/SwissProt for MEDAG Gene

Q5VYS4-MEDAG_HUMAN
Tissue specificity: Highly expressed in the visceral fat depot.
genes like me logo Genes that share expressions with MEDAG: view

Orthologs for MEDAG Gene

This gene was present in the common ancestor of chordates.

Orthologs for MEDAG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEDAG 36
  • 99.23 (n)
  • 99.34 (a)
MEDAG 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MEDAG 36
  • 90.1 (n)
  • 91.09 (a)
MEDAG 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEDAG 36
  • 91.81 (n)
  • 94.88 (a)
MEDAG 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Medag 36
  • 86.25 (n)
  • 91.42 (a)
Medag 16
Medag 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MEDAG 37
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEDAG 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Medag 36
  • 86.27 (n)
  • 92.03 (a)
lizard
(Anolis carolinensis)
Reptilia MEDAG 37
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia medag 36
  • 56.49 (n)
  • 45.38 (a)
Species with no ortholog for MEDAG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MEDAG Gene

ENSEMBL:
Gene Tree for MEDAG (if available)
TreeFam:
Gene Tree for MEDAG (if available)

Paralogs for MEDAG Gene

No data available for Paralogs for MEDAG Gene

Variants for MEDAG Gene

Sequence variations from dbSNP and Humsavar for MEDAG Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_030261 -

Relevant External Links for MEDAG Gene

HapMap Linkage Disequilibrium report
MEDAG

No data available for Structural Variations from Database of Genomic Variants (DGV) for MEDAG Gene

Disorders for MEDAG Gene

No disorders were found for MEDAG Gene.

No data available for UniProtKB/Swiss-Prot for MEDAG Gene

Publications for MEDAG Gene

  1. Novel genes of visceral adiposity: identification of mouse and human mesenteric estrogen-dependent adipose (MEDA)-4 gene and its adipogenic function. (PMID: 22510272) Zhang H. … Sairam M.R. (Endocrinology 2012) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for MEDAG Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MEDAG
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MEDAG
    • Block miRNA regulation of MEDAG using miScript Target Protectors

    Sources for MEDAG Gene

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