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Aliases for MED9 Gene

Aliases for MED9 Gene

  • Mediator Complex Subunit 9 2 3 4 5
  • MED25 3 4
  • Mediator Of RNA Polymerase II Transcription, Subunit 9 Homolog (S. Cerevisiae) 2
  • Mediator Of RNA Polymerase II Transcription, Subunit 9 Homolog 3
  • Mediator Of RNA Polymerase II Transcription Subunit 9 3
  • Mediator Subunit 25 3

External Ids for MED9 Gene

Previous GeneCards Identifiers for MED9 Gene

  • GC17P017322
  • GC17P017324
  • GC17P017380
  • GC17P017132

Summaries for MED9 Gene

Entrez Gene Summary for MED9 Gene

  • The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

GeneCards Summary for MED9 Gene

MED9 (Mediator Complex Subunit 9) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. GO annotations related to this gene include RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED9 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED9 Gene

Genomics for MED9 Gene

Regulatory Elements for MED9 Gene

Enhancers for MED9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G017444 1.3 Ensembl ENCODE 19 -31.0 -30995 3.2 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 FOS MED9 SMCR8 LOC644422 DRG2 RPL13P12 ACTG1P24 TOM1L2 GC17P017438 TSEN15P1
GH17G017580 1.4 Ensembl ENCODE dbSUPER 10.5 +104.4 104363 1.9 ELF3 MLX ARID4B KLF17 THRB RAD21 RARA YY1 PCBP1 MIXL1 MED9 PEMT LOC100419436 RNU6-468P ENSG00000264666
GH17G017401 1.2 Ensembl dbSUPER 11.4 -75.5 -75485 0.6 HDAC1 CBX3 PKNOX1 TBL1XR1 RAD21 TCF12 ZNF766 GATA2 ELK1 ZNF263 MED9 RPL13P12 LOC644909
GH17G017351 1.2 Ensembl ENCODE 11.1 -124.8 -124770 2.3 ATF1 FOXA2 ZFP64 GLIS2 FOS KDM4B SP5 GTF2B ZNF623 ZNF518A DRG2 MED9 LOC100419436 COPS3 RPL13P12 UPF3AP1 SMCR8 SMCR5 GC17P017341
GH17G017040 1.6 FANTOM5 ENCODE dbSUPER 8 -433.1 -433123 6.1 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 FLCN PLD6 MPRIP-AS1 SMCR5 ZNF624 MPRIP ZNF287 COPS3 RNU6-767P MED9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MED9 on UCSC Golden Path with GeneCards custom track

Promoters for MED9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000091921 214 1201 CREB3L1 SIN3A ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF207 SP3 SP5

Genomic Location for MED9 Gene

Chromosome:
17
Start:
17,476,986 bp from pter
End:
17,493,226 bp from pter
Size:
16,241 bases
Orientation:
Plus strand

Genomic View for MED9 Gene

Genes around MED9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED9 Gene

Proteins for MED9 Gene

  • Protein details for MED9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWA0-MED9_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 9
    Protein Accession:
    Q9NWA0

    Protein attributes for MED9 Gene

    Size:
    146 amino acids
    Molecular mass:
    16403 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

neXtProt entry for MED9 Gene

Post-translational modifications for MED9 Gene

  • Ubiquitination at Lys99
  • Modification sites at PhosphoSitePlus

Other Protein References for MED9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MED9 Gene

Domains & Families for MED9 Gene

Gene Families for MED9 Gene

Protein Domains for MED9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NWA0

UniProtKB/Swiss-Prot:

MED9_HUMAN :
  • Belongs to the Mediator complex subunit 9 family.
Family:
  • Belongs to the Mediator complex subunit 9 family.
genes like me logo Genes that share domains with MED9: view

Function for MED9 Gene

Molecular function for MED9 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IEA --
GO:0005515 protein binding IPI 14638676
genes like me logo Genes that share ontologies with MED9: view
genes like me logo Genes that share phenotypes with MED9: view

Animal Model Products

CRISPR Products

miRNA for MED9 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MED9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED9 Gene

Localization for MED9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MED9 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MED9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016592 mediator complex IBA --
genes like me logo Genes that share ontologies with MED9: view

Pathways & Interactions for MED9 Gene

genes like me logo Genes that share pathways with MED9: view

Gene Ontology (GO) - Biological Process for MED9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with MED9: view

No data available for SIGNOR curated interactions for MED9 Gene

Drugs & Compounds for MED9 Gene

No Compound Related Data Available

Transcripts for MED9 Gene

mRNA/cDNA for MED9 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MED9 Gene

Mediator complex subunit 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MED9

Alternative Splicing Database (ASD) splice patterns (SP) for MED9 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3
SP1: -
SP2: - -
SP3:

Relevant External Links for MED9 Gene

GeneLoc Exon Structure for
MED9
ECgene alternative splicing isoforms for
MED9

Expression for MED9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MED9 Gene

Protein differential expression in normal tissues from HIPED for MED9 Gene

This gene is overexpressed in Monocytes (30.7), Fetal Brain (11.8), CD4 Tcells (8.6), and Placenta (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MED9 Gene



NURSA nuclear receptor signaling pathways regulating expression of MED9 Gene:

MED9

SOURCE GeneReport for Unigene cluster for MED9 Gene:

Hs.244595

Evidence on tissue expression from TISSUES for MED9 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with MED9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED9 Gene

Orthologs for MED9 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED9 34 35
  • 99.32 (n)
dog
(Canis familiaris)
Mammalia MED9 34 35
  • 85.39 (n)
mouse
(Mus musculus)
Mammalia Med9 34 16 35
  • 83.21 (n)
rat
(Rattus norvegicus)
Mammalia Med9 34
  • 82.19 (n)
cow
(Bos Taurus)
Mammalia MED9 34 35
  • 79.08 (n)
oppossum
(Monodelphis domestica)
Mammalia MED9 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED9 34 35
  • 83.15 (n)
lizard
(Anolis carolinensis)
Reptilia MED9 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med9 34
  • 78.62 (n)
Str.15073 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.33549 34
zebrafish
(Danio rerio)
Actinopterygii si:ch73-105m5.1 34
  • 71.91 (n)
MED9 35
  • 65 (a)
OneToOne
Dr.28799 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10572 34
fruit fly
(Drosophila melanogaster)
Insecta MED9 35
  • 27 (a)
OneToOne
Species where no ortholog for MED9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MED9 Gene

ENSEMBL:
Gene Tree for MED9 (if available)
TreeFam:
Gene Tree for MED9 (if available)

Paralogs for MED9 Gene

Pseudogenes.org Pseudogenes for MED9 Gene

genes like me logo Genes that share paralogs with MED9: view

No data available for Paralogs for MED9 Gene

Variants for MED9 Gene

Sequence variations from dbSNP and Humsavar for MED9 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000166224 -- 17,487,229(+) CCACT(C/T)GGCTC intron-variant
rs1000411298 -- 17,478,634(+) GCGGG(C/T)GGATC intron-variant
rs1000479786 -- 17,492,360(+) CCCTT(G/T)CTCTG utr-variant-3-prime
rs1000527883 -- 17,489,767(+) TTTCC(C/T)GGCCT intron-variant
rs1000633677 -- 17,486,543(+) CAGCC(A/C)ACCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED9 Gene

Variant ID Type Subtype PubMed ID
nsv1065710 CNV gain 25217958
nsv155 OTHER inversion 15895083
nsv499114 OTHER inversion 21111241
nsv827909 CNV gain 20364138

Variation tolerance for MED9 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 45.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MED9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED9 Gene

Disorders for MED9 Gene

Relevant External Links for MED9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED9

No disorders were found for MED9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED9 Gene

Publications for MED9 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 3 4 64
  3. Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. (PMID: 11997338) Bi W. … Lupski J.R. (Genome Res. 2002) 2 3 64
  4. The Dual Estrogen Receptor I+ Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety. (PMID: 26487511) Han S.J. … O'Malley B.W. (Mol. Pharmacol. 2016) 3 64
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64

Products for MED9 Gene

  • Addgene plasmids for MED9

Sources for MED9 Gene

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