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Aliases for MED9 Gene

Aliases for MED9 Gene

  • Mediator Complex Subunit 9 2 3 4 5
  • MED25 3 4
  • Mediator Of RNA Polymerase II Transcription, Subunit 9 Homolog (S. Cerevisiae) 2
  • Mediator Of RNA Polymerase II Transcription, Subunit 9 Homolog 3
  • Mediator Subunit 25 3

External Ids for MED9 Gene

Previous GeneCards Identifiers for MED9 Gene

  • GC17P017322
  • GC17P017324
  • GC17P017380
  • GC17P017132

Summaries for MED9 Gene

Entrez Gene Summary for MED9 Gene

  • The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

GeneCards Summary for MED9 Gene

MED9 (Mediator Complex Subunit 9) is a Protein Coding gene. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED9 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED9 Gene

Genomics for MED9 Gene

Regulatory Elements for MED9 Gene

Promoters for MED9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MED9 on UCSC Golden Path with GeneCards custom track

Genomic Location for MED9 Gene

Chromosome:
17
Start:
17,476,986 bp from pter
End:
17,493,226 bp from pter
Size:
16,241 bases
Orientation:
Plus strand

Genomic View for MED9 Gene

Genes around MED9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED9 Gene

Proteins for MED9 Gene

  • Protein details for MED9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWA0-MED9_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 9
    Protein Accession:
    Q9NWA0

    Protein attributes for MED9 Gene

    Size:
    146 amino acids
    Molecular mass:
    16403 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

neXtProt entry for MED9 Gene

Proteomics data for MED9 Gene at MOPED

Post-translational modifications for MED9 Gene

  • Ubiquitination at Lys 99
  • Modification sites at PhosphoSitePlus

Other Protein References for MED9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MED9 Gene

Domains & Families for MED9 Gene

Gene Families for MED9 Gene

Protein Domains for MED9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NWA0

UniProtKB/Swiss-Prot:

MED9_HUMAN :
  • Belongs to the Mediator complex subunit 9 family.
Family:
  • Belongs to the Mediator complex subunit 9 family.
genes like me logo Genes that share domains with MED9: view

Function for MED9 Gene

Molecular function for MED9 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
genes like me logo Genes that share phenotypes with MED9: view

Animal Model Products

miRNA for MED9 Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED9 Gene

Localization for MED9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED9 Gene COMPARTMENTS Subcellular localization image for MED9 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for MED9 Gene

Pathways & Interactions for MED9 Gene

genes like me logo Genes that share pathways with MED9: view

Gene Ontology (GO) - Biological Process for MED9 Gene

None

No data available for SIGNOR curated interactions for MED9 Gene

Drugs & Compounds for MED9 Gene

No Compound Related Data Available

Transcripts for MED9 Gene

Unigene Clusters for MED9 Gene

Mediator complex subunit 9:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED9 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3
SP1: -
SP2: - -
SP3:

Relevant External Links for MED9 Gene

GeneLoc Exon Structure for
MED9
ECgene alternative splicing isoforms for
MED9

Expression for MED9 Gene

mRNA expression in normal human tissues for MED9 Gene

Protein differential expression in normal tissues from HIPED for MED9 Gene

This gene is overexpressed in Monocytes (30.7), Fetal Brain (11.8), CD4 Tcells (8.6), and Placenta (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED9 Gene



SOURCE GeneReport for Unigene cluster for MED9 Gene Hs.244595

genes like me logo Genes that share expression patterns with MED9: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MED9 Gene

Orthologs for MED9 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED9 35
  • 99.32 (n)
  • 100 (a)
MED9 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MED9 36
  • 80 (a)
OneToOne
MED9 35
  • 79.08 (n)
  • 75.86 (a)
dog
(Canis familiaris)
Mammalia MED9 35
  • 85.39 (n)
  • 84.25 (a)
MED9 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med9 16
Med9 35
  • 83.21 (n)
  • 80.92 (a)
Med9 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MED9 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med9 35
  • 82.19 (n)
  • 81.68 (a)
chicken
(Gallus gallus)
Aves MED9 36
  • 73 (a)
OneToOne
MED9 35
  • 83.15 (n)
  • 85.71 (a)
lizard
(Anolis carolinensis)
Reptilia MED9 36
  • 55 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33549 35
tropical clawed frog
(Silurana tropicalis)
Amphibia med9 35
  • 78.62 (n)
  • 78.26 (a)
Str.15073 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10572 35
zebrafish
(Danio rerio)
Actinopterygii MED9 36
  • 65 (a)
OneToOne
Dr.28799 35
si:ch73-105m5.1 35
  • 71.91 (n)
  • 68.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta MED9 36
  • 27 (a)
OneToOne
Species with no ortholog for MED9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MED9 Gene

ENSEMBL:
Gene Tree for MED9 (if available)
TreeFam:
Gene Tree for MED9 (if available)

Paralogs for MED9 Gene

Pseudogenes.org Pseudogenes for MED9 Gene

genes like me logo Genes that share paralogs with MED9: view

No data available for Paralogs for MED9 Gene

Variants for MED9 Gene

Sequence variations from dbSNP and Humsavar for MED9 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1242489 -- 17,491,297(-) ACCTC(C/T)GGGCT reference, synonymous-codon
rs1242490 -- 17,489,922(-) TTACG(C/G)AGGCA intron-variant
rs1242502 -- 17,478,450(+) GCAAA(C/T)TAGAT intron-variant
rs1242513 -- 17,480,506(+) CACGG(A/G)TCAGG intron-variant
rs1242514 -- 17,481,186(+) ACAGT(A/C)CTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED9 Gene

Variant ID Type Subtype PubMed ID
nsv155 OTHER Inversion 15895083
nsv499114 OTHER Inversion 21111241
nsv907729 CNV Loss 21882294
nsv907730 CNV Loss 21882294
nsv907731 CNV Loss 21882294
nsv827909 CNV Gain 20364138
dgv3067n71 CNV Loss 21882294
dgv3068n71 CNV Loss 21882294
nsv907737 CNV Loss 21882294

Variation tolerance for MED9 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 45.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MED9 Gene

HapMap Linkage Disequilibrium report
MED9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED9 Gene

Disorders for MED9 Gene

Relevant External Links for MED9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED9

No disorders were found for MED9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED9 Gene

Publications for MED9 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. (PMID: 11997338) Bi W. … Lupski J.R. (Genome Res. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Subunit architecture and functional modular rearrangements of the transcriptional mediator complex. (PMID: 24882805) Tsai K.L. … Asturias F.J. (Cell 2014) 3
  5. RNA-Seq for the identification of novel Mediator transcripts in endothelial progenitor cells. (PMID: 24952135) Rienzo M. … Napoli C. (Gene 2014) 3

Products for MED9 Gene

Sources for MED9 Gene

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