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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MED9 Gene

protein-coding   GIFtS: 49
GCID: GC17P017380

mediator complex subunit 9

(Previous names: mediator of RNA polymerase II transcription, subunit 9...)
 Explore 1 disease affiliated with
MED9 via our new
 Human Malady Compendium 
Biological research products
for MED9
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mediator Complex Subunit 91 2 3     Mediator Of RNA Polymerase II Transcription Subunit 92
MED251 2 3 5     Mediator Of RNA Polymerase II Transcription, Subunit 9 Homolog2
FLJ101931 5     Mediator Subunit 252
Mediator Of RNA Polymerase II Transcription, Subunit 9 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 254871   Entrez Gene: 550902   Ensembl: ENSG000001410267   OMIM: 6098785   UniProtKB: Q9NWA03   

Export aliases for MED9 gene to outside databases

Previous GC identifers: GC17P017322 GC17P017324 GC17P017132


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MED9:
The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA
bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This
gene is located within the Smith-Magenis syndrome region on chromosome 17. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MED9_HUMAN, Q9NWA0
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
with RNA polymerase II and the general transcription factors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MED9 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   USF1   oct-B3   oct-B2   POU2F2   POU2F2C   POU2F1   USF-1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED9 promoter sequence
   Search SABiosciences Chromatin IP Primers for MED9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

MED9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED9 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P017380:  view genomic region     (about GC identifiers)

Start:
17,380,300 bp from pter      End:
17,396,540 bp from pter
Size:
16,241 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MED9_HUMAN, Q9NWA0 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 9  
Size: 146 amino acids; 16403 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in
supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct
subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Subcellular location: Nucleus (Probable)

Explore the universe of human proteins at neXtProt for MED9: NX_Q9NWA0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NWA0

  • MED9 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060489.1  
    ENSEMBL proteins: 
     ENSP00000268711   ENSP00000463031   ENSP00000462204  
    Reactome Protein details: Q9NWA0
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MED9
    OriGene Protein Over-expression Lysate: MED9
    OriGene Custom Protein Services for MED9 
    GenScript Custom Purified and Recombinant Proteins Services for MED9
    Novus Biologicals MED9 Protein
    Novus Biologicals MED9 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MED9

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016592mediator complex IEA--


    MED9 for ontologies           About GeneDecksing



    MED9 Antibody Products: 
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    Novus Biologicals MED9 Antibodies
    Search for Antibodies for MED9 at Abcam  
    Uscn Antibodies for MED9
    Search ThermoFisher Antibodies for MED9

    Assay Products for MED9: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED9
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MED9


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MED9 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR011425 Mediator_Med9

    Graphical View of Domain Structure for InterPro Entry Q9NWA0

    ProtoNet protein and cluster: Q9NWA0

    UniProtKB/Swiss-Prot: MED9_HUMAN, Q9NWA0
    Similarity: Belongs to the Mediator complex subunit 9 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MED9_HUMAN, Q9NWA0
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
    polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
    proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
    interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
    with RNA polymerase II and the general transcription factors

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: MED9
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED9
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate MED9 (see all 9):
    hsa-miR-132 hsa-miR-619 hsa-miR-3922-3p hsa-miR-33a* hsa-miR-873 hsa-miR-935 hsa-miR-3176 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidMED9 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED9 (see all 6)
    OriGene siRNA: MED9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED9

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED9 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED9
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MED9 (NM_017510)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED9 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MED9
    Search LifeMap BioReagents cell lines for MED9

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED9

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IEA--
    GO:0005515protein binding IPI15175163


    MED9 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MED9:
     Decreased nuclei size in G2M 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transcriptional Regulation of White Adipocyte Differentiation
    Transcriptional Regulation of White Adipocyte Differentiation1.00
    2Axon guidance
    Developmental Biology0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for MED9
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation



    MED9 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MED9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/118 Interacting proteins for MED9 (Q9NWA01, 3 ENSP000002687114) via UniProtKB, MINT, STRING, and/or I2D (see all 118)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN2Q166373, ENSP000003701194I2D: score=1 STRING: ENSP00000370119
    MED4Q9NPJ61, 3, ENSP000002586484EBI-394653,EBI-394607 I2D: score=3 STRING: ENSP00000258648
    CDK8P493363, ENSP000003709384I2D: score=3 STRING: ENSP00000370938
    MED1Q156483, ENSP000003006514I2D: score=3 STRING: ENSP00000300651
    MED14O602443, ENSP000003237204I2D: score=3 STRING: ENSP00000323720
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MED9
    Search CenterWatch for drugs/clinical trials and news about MED9 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MED9 gene: 
    NM_018019.2  

    Unigene Cluster for MED9:

    Mediator complex subunit 9
    Hs.244595  [show with all ESTs]
    Unigene Representative Sequence: BC000647
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268711(uc002grh.1) ENST00000580462 ENST00000585041 ENST00000581315
    ENST00000580307

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: MED9
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED9
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate MED9 (see all 9):
    hsa-miR-132 hsa-miR-619 hsa-miR-3922-3p hsa-miR-33a* hsa-miR-873 hsa-miR-935 hsa-miR-3176 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidMED9 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED9 (see all 6)
    OriGene siRNA: MED9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED9
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED9 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED9
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MED9 (NM_017510)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED9 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED9
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED9
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED9

    Additional cDNA sequence: 

    AK001055.1 BC000647.2 BC104988.1 BC112029.1 

    8 DOTS entries:

    DT.212907  DT.95170098  DT.100774571  DT.100826344  DT.91805876  DT.95329619  DT.101973398  DT.86849787 

    24/167 AceView cDNA sequences (see all 167):

    T08017 BG472375 CR596182 BM557896 AI471032 AA320547 AA343494 AI017443 
    BM012511 BM977059 BU184265 BX331955 AK001055 BE296899 AA310161 AU131403 
    CR599337 AW874636 BM709681 BM693891 BM670952 BQ671138 BC000647 AL539405 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MED9    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3
    SP1:                          -         
    SP2:                    -     -         
    SP3:                                    


    ECgene alternative splicing isoforms for MED9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MED9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGCACGTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MED9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MED9

    SOURCE GeneReport for Unigene cluster: Hs.244595
        SABiosciences Custom PCR Arrays for MED9
    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED9
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED9
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MED9 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med91 , 5 mediator of RNA polymerase II transcription, subunit more1, 5 84.27(n)1
    80.28(a)1
      11 (37.81 cM)5
    1921911  NM_138675.31  NP_619616.21 
     599482065 
    chicken
    (Gallus gallus)
    Aves MED91 mediator complex subunit 9 77.98(n)
    77.06(a)
      416506  XM_414810.3  XP_414810.1 
    lizard
    (Anolis carolinensis)
    Reptilia MED96
    --
    56(a)
    1 ↔ 1
    GL343500.1(295754-298666)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.335492 Xenopus laevis transcribed sequence with weak similarity more 78.37(n)    BJ617631.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.287992 Transcribed sequence with weak similarity to protein more 76.16(n)    CK353822.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED96
    Mediator complex subunit 9
    26(a)
    1 ↔ 1
    2R(14054760-14055885)


    ENSEMBL Gene Tree for MED9 (if available)
    TreeFam Gene Tree for MED9 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MED9 gene

    MED9 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MED9
    PGOHUM00000237185


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/320 NCBI SNPs in MED9 are shown (see all 320    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1451653751,2
    --17378361(+) GGATCC/TGAAGT 1 -- us2k10--------
    rs1491415831,2
    --17378491(+) CATCTA/TCTAGA 1 -- us2k10--------
    rs26949271,2
    C,F,A,H,--17378504(+) TCTGTT/CTGTGG 1 -- us2k1 tfbs324Minor allele frequency- C:0.46NS EA NA WA CSA 2352
    rs1900605851,2
    --17378578(+) TTACTA/GTTATT 1 -- us2k10--------
    rs773894501,2
    F,--17378600(+) TATATC/AATCTT 1 -- us2k11Minor allele frequency- A:0.04EA 120
    rs756515811,2
    F,--17378734(+) ACTCCG/ACAACC 1 -- us2k11Minor allele frequency- A:0.10WA 118
    rs1827118721,2
    --17378773(+) GCACCA/GTGGGC 1 -- us2k10--------
    rs1464518421,2
    --17378833(+) ACAGCA/GCACCC 1 -- us2k10--------
    rs12424981,2
    C,F,A,H,--17378887(+) CCTCCG/TCACAG 1 -- us2k125Minor allele frequency- T:0.41EA NS NA WA CSA 3790
    rs12424991,2
    C,F,A,H,--17379267(+) CATGAA/CTCTGA 1 -- us2k137Minor allele frequency- C:0.46EA NA NS WA CSA 4818

    HapMap Linkage Disequilibrium report for MED9 (17380300 - 17396540 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MED9
         1 Inversion: 0495

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MED9
    DNA2.0 Custom Variant and Variant Library Synthesis for MED9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MED9 for disorders           About GeneDecksing

    OMIM gene information: 609878    OMIM disorders: --

    1 disease for MED9:    About MalaCards
    smith-magenis syndrome


    Export disorders for MED9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MED9 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with MED9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S....Conaway R.C. (2004)
    3. Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. (PubMed id 11997338)1, 3 Bi W....Lupski J.R. (2002)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. CDK8 is a positive regulator of transcriptional elong ation within the serum response network. (PubMed id 20098423)1 Donner A.J....Espinosa J.M. (2010)
    9. Streamlined analysis schema for high-throughput ident ification of endogenous protein complexes. (PubMed id 20133760)1 Malovannaya A....Qin J. (2010)
    10. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)2 Zhang X....Roeder R.G. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55090 HGNC: 25487 AceView: MED25 Ensembl:ENSG00000141026 euGenes: HUgn55090
    ECgene: MED9 H-InvDB: MED9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MED9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MED9 gene:
    Search GeneIP for patents involving MED9

    GeneCards and IP:
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