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MED9 Gene

protein-coding   GIFtS: 50
GCID: GC17P017380

Mediator Complex Subunit 9

(Previous names: mediator of RNA polymerase II transcription, subunit 9 homolog...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mediator Complex Subunit 91 2 3     Mediator Of RNA Polymerase II Transcription, Subunit 9 Homolog2
MED252 3 5     Mediator Subunit 252
Mediator Of RNA Polymerase II Transcription, Subunit 9 Homolog (S.
Cerevisiae)1
     FLJ101935
Mediator Of RNA Polymerase II Transcription Subunit 92     

External Ids:    HGNC: 254871   Entrez Gene: 550902   Ensembl: ENSG000001410267   OMIM: 6098785   UniProtKB: Q9NWA03   

Export aliases for MED9 gene to outside databases

Previous GC identifers: GC17P017322 GC17P017324 GC17P017132


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MED9 Gene:
The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by
DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator
complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. (provided by RefSeq, Jul
2008)

GeneCards Summary for MED9 Gene:
MED9 (mediator complex subunit 9) is a protein-coding gene. GO annotations related to this gene include RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot: MED9_HUMAN, Q9NWA0
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MED9 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   USF1   oct-B3   oct-B2   POU2F2   POU2F2C   POU2F1   USF-1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED9 promoter sequence
   Search Chromatin IP Primers for MED9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MED9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

MED9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED9 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P017380:  view genomic region     (about GC identifiers)

Start:
17,380,300 bp from pter      End:
17,396,540 bp from pter
Size:
16,241 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MED9_HUMAN, Q9NWA0 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 9  
Size: 146 amino acids; 16403 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP

Explore the universe of human proteins at neXtProt for MED9: NX_Q9NWA0

Explore proteomics data for MED9 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys99
  • Modification sites at PhosphoSitePlus

  • See MED9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060489.1  
    ENSEMBL proteins: 
     ENSP00000268711   ENSP00000463031   ENSP00000462204  
    Reactome Protein details: Q9NWA0

    MED9 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for MED9
    OriGene Protein Over-expression Lysate for MED9
    OriGene MassSpec for MED9
    OriGene Custom Protein Services for MED9
    GenScript Custom Purified and Recombinant Proteins Services for MED9
    Novus Biologicals MED9 Protein
    Novus Biologicals MED9 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MED9

     
    Search eBioscience for Proteins for MED9 

     
    antibodies-online proteins for MED9 (5 products) 

     
    antibodies-online peptides for MED9

    MED9 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals MED9 Antibodies
    Search for Antibodies for MED9 at Abcam
    Cloud-Clone Corp. Antibodies for MED9
    Search ThermoFisher Antibodies for MED9
    antibodies-online antibodies for MED9 (11 products) 

    MED9 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED9
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    GenScript Custom Assay Services for MED9
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED9
    Cloud-Clone Corp. CLIAs for MED9
    Search eBioscience for ELISAs for MED9 
    antibodies-online kits for MED9 (18 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR011425 Mediator_Med9

    Graphical View of Domain Structure for InterPro Entry Q9NWA0

    ProtoNet protein and cluster: Q9NWA0

    UniProtKB/Swiss-Prot: MED9_HUMAN, Q9NWA0
    Similarity: Belongs to the Mediator complex subunit 9 family


    Find genes that share domains with MED9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED9_HUMAN, Q9NWA0
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IEA--
    GO:0005515protein binding IPI14638676
         
    Find genes that share ontologies with MED9           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MED9:
     Decreased nuclei size in G2M 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MED9

    miRNA
    Products:
        
    miRTarBase miRNAs that target MED9:
    hsa-mir-26b-5p (MIRT029693)

    Block miRNA regulation of human, mouse, rat MED9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MED9 (see all 9):
    hsa-miR-132 hsa-miR-619 hsa-miR-3922-3p hsa-miR-33a* hsa-miR-873 hsa-miR-935 hsa-miR-3176 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidMED9 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MED9
    Predesigned siRNA for gene silencing in human, mouse, rat MED9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED9

    Clone
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    OriGene clones in human, mouse for MED9 (see all 6)
    OriGene ORF clones in mouse, rat for MED9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED9 (NM_017510)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED9
    Addgene plasmids for MED9 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MED9
    Browse ESI BIO Cell Lines and PureStem Progenitors for MED9 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MED9_HUMAN, Q9NWA0: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016592mediator complex IEA--

    Find genes that share ontologies with MED9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MED9 About    
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3L1CAM interactions
    Developmental Biology0.63


    Find genes that share SuperPaths with MED9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for MED9
        Transcriptional regulation of white adipocyte differentiation
    PPARA activates gene expression


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MED9
    Interactions:

        Search GeneGlobe Interaction Network for MED9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MED9 (Q9NWA01, 3 ENSP000002687114) via UniProtKB, MINT, STRING, and/or I2D (see all 121)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000234258P349313, ENSP000003964864I2D: score=1 STRING: ENSP00000396486
    ENSG00000206383P349313I2D: score=1 
    ENSG00000236251P349313I2D: score=1 
    HSPA1LP349313I2D: score=1 
    SMN2Q166373, ENSP000003701194I2D: score=1 STRING: ENSP00000370119
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter ----

    Find genes that share ontologies with MED9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MED9



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MED9 gene: 
    NM_018019.2  

    Unigene Cluster for MED9:

    Mediator complex subunit 9
    Hs.244595  [show with all ESTs]
    Unigene Representative Sequence: BC000647
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268711(uc002grh.1) ENST00000580462 ENST00000585041 ENST00000581315

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MED9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MED9 (see all 9):
    hsa-miR-132 hsa-miR-619 hsa-miR-3922-3p hsa-miR-33a* hsa-miR-873 hsa-miR-935 hsa-miR-3176 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidMED9 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MED9
    Predesigned siRNA for gene silencing in human, mouse, rat MED9
    Clone
    Products:
         
    OriGene clones in human, mouse for MED9 (see all 6)
    OriGene ORF clones in mouse, rat for MED9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED9 (NM_017510)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED9
    Addgene plasmids for MED9 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MED9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED9
      QuantiTect SYBR Green Assays in human, mouse, rat MED9
      QuantiFast Probe-based Assays in human, mouse, rat MED9

    Additional mRNA sequence: 

    AK001055.1 BC000647.2 BC104988.1 BC112029.1 

    8 DOTS entries:

    DT.212907  DT.95170098  DT.100774571  DT.100826344  DT.91805876  DT.95329619  DT.101973398  DT.86849787 

    Selected AceView cDNA sequences (see all 167):

    BU184265 AK001055 AW874636 AA310161 BE296899 BQ671138 BM709681 AI017443 
    BM012511 AI471032 BX331955 BG472375 AA320547 T08017 BM557896 BM670952 
    BM977059 CR596182 CR599337 BM693891 AA343494 AU131403 AA340740 AL539405 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MED9    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3
    SP1:                          -         
    SP2:                    -     -         
    SP3:                                    


    ECgene alternative splicing isoforms for MED9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MED9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCACGTGG
    MED9 Expression
    About this image

    MED9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MED9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.244595
        Custom PCR Arrays for MED9
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MED9 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med91 , 5 mediator of RNA polymerase II transcription, subunit more5
    mediator complex subunit 91
    83.21(n)1
    80.92(a)1
      11 (37.81 cM)5
    1921911  NM_138675.31  NP_619616.21 
     599482065 
    chicken
    (Gallus gallus)
    Aves MED91 mediator complex subunit 9 83.15(n)
    85.71(a)
      416506  NM_001277637.1  NP_001264566.1 
    lizard
    (Anolis carolinensis)
    Reptilia MED96
    mediator complex subunit 9
    55(a)
    1 ↔ 1
    GL343500.1(295754-298666)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.335492 Xenopus laevis transcribed sequence with weak similarity more 78.37(n)    BJ617631.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.287992 Transcribed sequence with weak similarity to protein more 76.16(n)    CK353822.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED96
    Mediator complex subunit 9
    27(a)
    1 ↔ 1
    2R(14054760-14055885)


    ENSEMBL Gene Tree for MED9 (if available)
    TreeFam Gene Tree for MED9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MED9 gene

    Find genes that share paralogs with MED9           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MED9
    PGOHUM00000237185


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MED9 (see all 371)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1451653751,2
    --17378361(+) GGATCC/TGAAGT 1 -- us2k10--------
    rs1491415831,2
    --17378491(+) CATCTA/TCTAGA 1 -- us2k10--------
    rs26949271,2
    C,F,A,H--17378504(+) TCTGTT/CTGTGG 1 -- us2k1 tfbs324Minor allele frequency- C:0.46NS EA NA WA CSA 2352
    rs1900605851,2
    --17378578(+) TTACTA/GTTATT 1 -- us2k10--------
    rs773894501,2
    C,F--17378600(+) TATATC/AATCTT 1 -- us2k11Minor allele frequency- A:0.04EA 120
    rs756515811,2
    C,F--17378734(+) ACTCCG/ACAACC 1 -- us2k11Minor allele frequency- A:0.10WA 118
    rs1827118721,2
    --17378773(+) GCACCA/GTGGGC 1 -- us2k10--------
    rs1464518421,2
    C--17378833(+) ACAGCA/GCACCC 1 -- us2k10--------
    rs12424981,2
    C,F,A,H--17378887(+) CCTCCG/TCACAG 1 -- us2k125Minor allele frequency- T:0.41EA NS NA WA CSA 3790
    rs12424991,2
    C,F,A,H--17379267(+) CATGAA/CTCTGA 1 -- us2k137Minor allele frequency- C:0.46EA NA NS WA CSA 4818

    HapMap Linkage Disequilibrium report for MED9 (17380300 - 17396540 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for MED9:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv907730CNV Loss21882294
    dgv3068n71CNV Loss21882294
    nsv907731CNV Loss21882294
    nsv907729CNV Loss21882294
    dgv3067n71CNV Loss21882294
    nsv907737CNV Loss21882294
    nsv827909CNV Gain20364138
    nsv155OTHER Inversion15895083
    nsv499114OTHER Inversion21111241

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MED9
    DNA2.0 Custom Variant and Variant Library Synthesis for MED9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609878    OMIM disorders: --


    Find genes that share disorders with MED9           About GenesLikeMe


    Export disorders for MED9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MED9 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with MED9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S.... Conaway R.C. (Mol. Cell 2004)
    3. Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. (PubMed id 11997338)1, 3 Bi W....Lupski J.R. (Genome Res. 2002)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. (PubMed id 23322298)1 Davis M.A....Clurman B.E. (amp 2013)
    6. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. Human mediator subunit MED26 functions as a docking site for transcription elongation factors. (PubMed id 21729782)1 Takahashi H....Conaway J.W. (Cell 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55090 HGNC: 25487 AceView: MED25 Ensembl:ENSG00000141026 euGenes: HUgn55090
    ECgene: MED9 H-InvDB: MED9

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MED9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MED9 gene:
    Search GeneIP for patents involving MED9

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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