Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MED7 Gene

protein-coding   GIFtS: 57
GCID: GC05M156564

Mediator Complex Subunit 7

(Previous names: cofactor required for Sp1 transcriptional activation, subunit...)
(Previous symbol: CRSP9)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Mediator Complex Subunit 71 2 3     CRSP Complex Subunit 92 3
CRSP91 2 3 5     RNA Polymerase Transcriptional Regulation Mediator Subunit 7 Homolog2 3
Cofactor Required For Sp1 Transcriptional Activation, Subunit 9, 33kDa1 2     CRSP332 5
Activator-Recruited Cofactor 34 KDa Component2 3     Cofactor Required For Sp1 Transcriptional Activation, Subunit 9 (33kD)2
Cofactor Required For Sp1 Transcriptional Activation Subunit 92 3     Mediator Of RNA Polymerase II Transcription Subunit 72
Transcriptional Coactivator CRSP332 3     hMED73
ARC342 3     

External Ids:    HGNC: 23781   Entrez Gene: 94432   Ensembl: ENSG000001558687   OMIM: 6050455   UniProtKB: O435133   

Export aliases for MED7 gene to outside databases

Previous GC identifers: GC05M156495 GC05M151653


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MED7 Gene:
The activation of gene transcription is a multistep process that is triggered by factors that recognize
transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation
by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required
for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein
is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which
interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and
cofactors. Two transcript variants encoding the same protein have been found for this gene. (provided by RefSeq,
Jul 2008)

GeneCards Summary for MED7 Gene:
MED7 (mediator complex subunit 7) is a protein-coding gene. GO annotations related to this gene include RNA polymerase II transcription cofactor activity and transcription coactivator activity.

UniProtKB/Swiss-Prot: MED7_HUMAN, O43513
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the MED7 gene promoter:
         AREB6   C/EBPbeta   AML1a   Nkx2-5   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED7 promoter sequence
   Search Chromatin IP Primers for MED7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MED7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q33.3

MED7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED7 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M156564:  view genomic region     (about GC identifiers)

Start:
156,564,423 bp from pter      End:
156,586,030 bp from pter
Size:
21,608 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MED7_HUMAN, O43513 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 7  
Size: 233 amino acids; 27245 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP

Explore the universe of human proteins at neXtProt for MED7: NX_O43513

Explore proteomics data for MED7 at MOPED

Post-translational modifications: 

  • Constitutively sumoylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MED7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001094286.1  NP_004261.1  

    ENSEMBL proteins: 
     ENSP00000286317   ENSP00000430746   ENSP00000401046  
    Reactome Protein details: O43513

    MED7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MED7
    OriGene Protein Over-expression Lysate for MED7
    OriGene MassSpec for MED7
    OriGene Custom Protein Services for MED7
    GenScript Custom Purified and Recombinant Proteins Services for MED7
    Novus Biologicals MED7 Proteins
    Novus Biologicals MED7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MED7
    Cloud-Clone Corp. Proteins for MED7

     
    Search eBioscience for Proteins for MED7 

    MED7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MED7
    Novus Biologicals MED7 Antibodies
    Abcam antibodies for MED7
    Cloud-Clone Corp. Antibodies for MED7
    ThermoFisher Antibodies for MED7
    LSBio Antibodies in human, mouse, rat for MED7

    MED7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED7
    Cloud-Clone Corp. CLIAs for MED7
    Search eBioscience for ELISAs for MED7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR009244 Mediatior_Med7

    Graphical View of Domain Structure for InterPro Entry O43513

    ProtoNet protein and cluster: O43513

    1 Blocks protein domain: IPB009244 MED7

    UniProtKB/Swiss-Prot: MED7_HUMAN, O43513
    Similarity: Belongs to the Mediator complex subunit 7 family


    Find genes that share domains with MED7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED7_HUMAN, O43513
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IEA--
    GO:0003713transcription coactivator activity TAS9989412
    GO:0005515protein binding IPI18391015
         
    Find genes that share ontologies with MED7           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for MED7:
     Decreased TP53 protein express  Decreased Tat-dependent transc  Decreased p24 protein expressi 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MED7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MED7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MED7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MED7

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat MED7 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MED7:
    hsa-miR-499-5p hsa-miR-1322
    SwitchGear 3'UTR luciferase reporter plasmidMED7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MED7
    Predesigned siRNA for gene silencing in human, mouse, rat MED7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED7

    Clone
    Products:
         
    OriGene clones in human, mouse for MED7 (see all 13)
    OriGene ORF clones in mouse, rat for MED7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MED7 (NM_004270)
    Sino Biological Human cDNA Clone for MED7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED7
    Addgene plasmids for MED7 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MED7
    Browse ESI BIO Cell Lines and PureStem Progenitors for MED7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MED7_HUMAN, O43513: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IDA9989412
    GO:0005739mitochondrion IDA--
    GO:0016592mediator complex IEA--

    Find genes that share ontologies with MED7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MED7 About    
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    4L1CAM interactions
    Developmental Biology0.63
    5Transcription Ligand Dependent Transcription of Retinoid Target genes
    Transcription Ligand Dependent Transcription of Retinoid Target genes


    Find genes that share SuperPaths with MED7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for MED7
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    3 Reactome Pathways for MED7
        Transcriptional regulation of white adipocyte differentiation
    Generic Transcription Pathway
    PPARA activates gene expression


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MED7
    Interactions:

        Search GeneGlobe Interaction Network for MED7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MED7 (O435132, 3 ENSP000002863174) via UniProtKB, MINT, STRING, and/or I2D (see all 249)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000224145Q9C0193, ENSP000003982244I2D: score=1 STRING: ENSP00000398224
    ENSG00000137384Q9C0193I2D: score=1 
    ENSG00000227147Q9C0193I2D: score=1 
    ENSG00000233599Q9C0193I2D: score=1 
    ENSG00000235259Q9C0193I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA9989412
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0019827stem cell maintenance IEA--

    Find genes that share ontologies with MED7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MED7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MED7 gene (2 alternative transcripts): 
    NM_001100816.1  NM_004270.4  

    Unigene Cluster for MED7:

    Mediator complex subunit 7
    Hs.279902  [show with all ESTs]
    Unigene Representative Sequence: BU902340
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000286317(uc003lwm.4) ENST00000524289 ENST00000420343(uc010jik.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MED7 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MED7:
    hsa-miR-499-5p hsa-miR-1322
    SwitchGear 3'UTR luciferase reporter plasmidMED7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MED7
    Predesigned siRNA for gene silencing in human, mouse, rat MED7
    Clone
    Products:
         
    OriGene clones in human, mouse for MED7 (see all 13)
    OriGene ORF clones in mouse, rat for MED7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MED7 (NM_004270)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED7
    Addgene plasmids for MED7 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MED7
    OriGene qSTAR qPCR primer pairs in human, mouse for MED7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED7
      QuantiTect SYBR Green Assays in human, mouse, rat MED7
      QuantiFast Probe-based Assays in human, mouse, rat MED7

    Additional mRNA sequence: 

    AF104251.1 BT007368.1 CR457009.1 CR541696.1 

    3 DOTS entries:

    DT.97839882  DT.444583  DT.91728563 

    Selected AceView cDNA sequences (see all 183):

    BM698562 BC006968 AW295321 CK905893 AA614666 AA195720 AI284492 CB047306 
    AA722901 BC005250 AI423955 AI767723 BQ011916 AA938620 BI828953 AF104251 
    CF529528 AA731165 CR617029 BQ223113 BF591574 AV713281 BU902340 BQ721490 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MED7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGATGTTT
    MED7 Expression
    About this image

    MED7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MED7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.279902
        Custom PCR Arrays for MED7
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MED7
    OriGene qSTAR qPCR primer pairs in human, mouse for MED7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED7
    QuantiTect SYBR Green Assays in human, mouse, rat MED7
    QuantiFast Probe-based Assays in human, mouse, rat MED7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MED7 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med71 , 5 mediator complex subunit 71, 5 91.27(n)1
    97(a)1
      11 (27.88 cM)5
    662131  NM_025426.31  NP_079702.31 
     464369255 
    chicken
    (Gallus gallus)
    Aves MED71 mediator complex subunit 7 80.72(n)
    89.13(a)
      100857575  XM_003642058.2  XP_003642106.1 
    lizard
    (Anolis carolinensis)
    Reptilia MED76
    mediator complex subunit 7
    87(a)
    1 ↔ 1
    GL343205.1(2568242-2568934)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX844467.12   -- 77.8(n)    BX844467.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd99d122 wufd99d12 77.86(n)   326098  BC046018.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED71 Mediator complex subunit 7 55.13(n)
    55.77(a)
      41288  NM_169357.2  NP_731500.1 
    worm
    (Caenorhabditis elegans)
    Secernentea let-491 let-49 48.24(n)
    37.65(a)
      173353  NM_061184.3  NP_493585.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MED7(YOL135C)4 Subunit of the RNA polymerase II mediator complex; more   --   15(70044-69376) 853985  NP_014506.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G035001 AT5G03500 49.38(n)
    35.8(a)
      831822  NM_001203286.1  NP_001190215.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g06618001 Os04g0661800 49.79(n)
    40(a)
      4337290  NM_001060686.2  NP_001054151.1 


    ENSEMBL Gene Tree for MED7 (if available)
    TreeFam Gene Tree for MED7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MED7 gene
    1 SIMAP similar gene for MED7 using alignment to 2 protein entries:     MED7_HUMAN (see all proteins):
    CRSP9

    Find genes that share paralogs with MED7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MED7 (see all 154)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1154881411,2
    C,F--156565061(+) AAGAAA/GATGTA 2 -- ds50011Minor allele frequency- G:0.04WA 118
    rs360367511,2
    C,F--156565072(+) TAGCTG/AATGAC 2 -- ds50011Minor allele frequency- A:0.50NA 2
    rs360733521,2
    C--156565104(+) ATTAA-/TGTCTG 2 -- ds50011Minor allele frequency- T:0.00CSA 2
    rs1121912621,2
    C--156565125(+) TGACCG/AAAGGA 2 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs2006358881,2
    C--156565150(+) ACTGG-/AAAAAA 2 -- ds50010--------
    rs1464269391,2
    --156565202(+) GGATAA/GGGAGA 2 -- ds50010--------
    rs1491051331,2
    --156565221(+) AGCTAA/GTGGGT 2 -- ds50010--------
    rs37978511,2
    C,F,H--156565372(+) ATGTAG/TAGAGC 2 -- ds500122Minor allele frequency- T:0.24EA NS NA WA CSA 3797
    rs1811164201,2
    --156565429(+) TTTTCA/GAAGAC 2 -- ds50010--------
    rs1856118951,2
    --156565561(+) CACTCA/GTTTGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for MED7 (156564423 - 156586030 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MED7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv272962CNV Insertion20981092
    esv271175CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MED7
    DNA2.0 Custom Variant and Variant Library Synthesis for MED7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605045    OMIM disorders: --


    Find genes that share disorders with MED7           About GenesLikeMe

    Genetic Association Database (GAD): MED7
    Human Genome Epidemiology (HuGE) Navigator: MED7 (1 document)

    Export disorders for MED7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MED7 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with MED7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. (PubMed id 9989412)1, 2, 3 Ryu S.... Tjian R. (Nature 1999)
    2. Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. (PubMed id 17709345)1, 2 Jakobs A.... Niedenthal R. (Nucleic Acids Res. 2007)
    3. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (Mol. Cell 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S.... Conaway R.C. (Mol. Cell 2004)
    6. Composite co-activator ARC mediates chromatin-directed transcriptional activation. (PubMed id 10235267)1, 2 Naeaer A.M....Tjian R. (Nature 1999)
    7. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. (PubMed id 9671713)1, 2 Jiang Y.W.... Kornberg R.D. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    8. Identification of the hypoxia-inducible factor 2I+ nuclear interactome in melanoma cells reveals master proteins involved in melanoma development. (PubMed id 23275444)1 Steunou A.L....Nieto L. (amp 2013)
    9. A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction. (PubMed id 23563140)1 Tsai K.L....Asturias F.J. (amp 2013)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9443 HGNC: 2378 AceView: CRSP9andMGC26988 Ensembl:ENSG00000155868 euGenes: HUgn9443
    ECgene: MED7 H-InvDB: MED7

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MED7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MED7 gene:
    Search GeneIP for patents involving MED7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MED7  
     OriGene qPCR primer pairs and template standards for MED7   OriGene Protein Over-expression Lysate for MED7  
     OriGene MassSpec something-or-other for MED7   OriGene clones in human, mouse for MED7  
     OriGene qSTAR qPCR primer pairs in human, mouse for MED7   OriGene Purified Protein for MED7  
     OriGene ORF clones in mouse, rat for MED7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MED7   OriGene Custom Protein Services for MED7  

     
     
     Block miRNA regulation of human, mouse, rat MED7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MED7
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MED7 Predesigned siRNA for gene silencing in human, mouse, rat MED7
     QuantiFast Probe-based Assays in human, mouse, rat MED7 QuantiTect SYBR Green Assays in human, mouse, rat MED7
     Custom PCR Arrays for MED7 Search Chromatin IP Primers for MED7
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED7  Search GeneGlobe Interaction Network for MED7
     Regulatory tfbs in MED7 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MED7 GenScript cDNA clones with any tag delivered in your preferred vector for MED7
     GenScript Custom Assay Services for MED7 GenScript Custom overexpressing Cell Line Services for MED7
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MED7
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for MED7
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MED7 antibodies
     MED7 proteins
     MED7 lysates
     Antibodies for MED7
     See all of Abcam's Antibodies, Kits and Proteins for MED7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for MED7
     Proteins for MED7
     Antibodies for MED7
     ELISAs for MED7
     CLIAs for MED7



     Browse ESI BIO Cell Lines and PureStem Progenitors for MED7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED7
     SwitchGear 3'UTR luciferase reporter plasmids for MED7
     SwitchGear Promoter luciferase reporter plasmids for MED7
     ThermoFisher Antibodies for MED7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED7
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MED7
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MED7
     LSBio Antibodies in human, mouse, rat for MED7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for MED7
      Search eBioscience for proteins for MED7
      Search eBioscience for elisas for MED7
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MED7 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4