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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MED7 Gene

protein-coding   GIFtS: 55
GCID: GC05M156564

mediator complex subunit 7

(Previous names: cofactor required for Sp1 transcriptional activation, subunit...)
(Previous symbol: CRSP9)
 Explore 2 diseases affiliated with
MED7 via our new
 Human Malady Compendium 
Biological research products
for MED7
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mediator Complex Subunit 71 2 3     ARC342 3
CRSP91 2 3 5     CRSP Complex Subunit 92 3
CRSP331 2 5     RNA Polymerase Transcriptional Regulation Mediator Subunit 7 Homolog2 3
Cofactor Required For Sp1 Transcriptional Activation, Subunit 9, 33kDa1 2     Cofactor Required For Sp1 Transcriptional Activation, Subunit 9 (33kD)2
Activator-Recruited Cofactor 34 KDa Component2 3     Mediator Of RNA Polymerase II Transcription Subunit 72
Cofactor Required For Sp1 Transcriptional Activation Subunit 92 3     HMED71
Transcriptional Coactivator CRSP332 3     

External Ids:    HGNC: 23781   Entrez Gene: 94432   Ensembl: ENSG000001558687   OMIM: 6050455   UniProtKB: O435133   

Export aliases for MED7 gene to outside databases

Previous GC identifers: GC05M156495 GC05M151653


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MED7:
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional
enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA
polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1
activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a
component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with
TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript
variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MED7_HUMAN, O43513
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED7


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MED7 gene promoter:
         AREB6   C/EBPbeta   AML1a   Nkx2-5   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED7 promoter sequence
   Search SABiosciences Chromatin IP Primers for MED7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q33.3

MED7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED7 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M156564:  view genomic region     (about GC identifiers)

Start:
156,564,423 bp from pter      End:
156,586,030 bp from pter
Size:
21,608 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MED7_HUMAN, O43513 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 7  
Size: 233 amino acids; 27245 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in
supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct
subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Subcellular location: Nucleus

Explore the universe of human proteins at neXtProt for MED7: NX_O43513

Post-translational modifications:

  • Constitutively sumoylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43513

  • MED7 Protein expression data from MOPED and PaxDb:    About this image 
    MED7 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001094286.1  NP_004261.1  

    ENSEMBL proteins: 
     ENSP00000286317   ENSP00000430746   ENSP00000401046  
    Reactome Protein details: O43513
    Human Recombinant Protein Products for MED7: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MED7
    OriGene Protein Over-expression Lysate (see all 3): MED7
    OriGene Custom Protein Services for MED7 
    GenScript Custom Purified and Recombinant Proteins Services for MED7
    Novus Biologicals MED7 Protein
    Novus Biologicals MED7 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for MED7
    Uscn Proteins for MED7

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IDA9989412
    GO:0016592mediator complex IEA--

    MED7 for ontologies           About GeneDecksing



    MED7 Antibody Products: 
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    Novus Biologicals MED7 Antibodies
    Abcam antibodies for MED7 
    Uscn Antibodies for MED7
    Search ThermoFisher Antibodies for MED7

    Assay Products for MED7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED7
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MED7


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MED7 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009244 Mediatior_Med7

    Graphical View of Domain Structure for InterPro Entry O43513

    ProtoNet protein and cluster: O43513

    1 Blocks protein family: IPB009244 MED7

    UniProtKB/Swiss-Prot: MED7_HUMAN, O43513
    Similarity: Belongs to the Mediator complex subunit 7 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED7_HUMAN, O43513
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
    polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
    proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
    interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
    with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IEA--
    GO:0003713transcription coactivator activity TAS9989412
    GO:0005515protein binding IPI18391015
         
    MED7 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MED7:
     Decreased TP53 protein express  Decreased Tat-dependent transc  Decreased p24 protein expressi 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MED7 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 2): MED7
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED7
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MED7:
    hsa-miR-499-5p hsa-miR-1322
    SwitchGear 3'UTR luciferase reporter plasmidMED7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED7
    OriGene shRNA RFP: MED7
    OriGene siRNA: MED7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED7
    Sirion Biotech Custom design and validation of potent shRNA sequences against MED7 

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for MED7
    Sirion Biotech Customized adenovirus for overexpression of MED7 
    Sirion Biotech Customized adenovirus for potent knockdown of MED7

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED7 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED7 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MED7 (NM_004270)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED7 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MED7
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    Sirion Biotech Customized stable knockdown cell line services for MED7 
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    Sirion Biotech Customized stable overexpressing cell line services for MED7
    Sirion Biotech Customized inducible overexpressing cell line services for MED7

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46
    2HIV Infection
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes0.28
    Transcription_Ligand-Dependent Transcription of Retinoid-Target genes0.28
    3Transcriptional Regulation of White Adipocyte Differentiation
    Transcriptional Regulation of White Adipocyte Differentiation1.00
    4Axon guidance
    Developmental Biology0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for MED7
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    1 GeneGo (Thomson Reuters) Pathway for MED7
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    4        Reactome Pathways for MED7
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation
    Generic Transcription Pathway
    Gene Expression



    MED7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MED7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/123 Interacting proteins for MED7 (O435132, 3 ENSP000002863174) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HGSO149642, 3, ENSP000003312014MINT-67966 I2D: score=5 STRING: ENSP00000331201
    MED10Q9BTT43, ENSP000002557644I2D: score=3 STRING: ENSP00000255764
    FXR2P511163, ENSP000002501134I2D: score=2 STRING: ENSP00000250113
    MED19A0JLT23, ENSP000003373404STRING: ENSP00000337340 I2D: score=2 
    MED8Q96G253, ENSP000002906634I2D: score=2 STRING: ENSP00000290663
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA9989412
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0019827stem cell maintenance IEA--

    MED7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MED7
    Search CenterWatch for drugs/clinical trials and news about MED7 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MED7 gene (2 alternative transcripts): 
    NM_001100816.1  NM_004270.4  

    Unigene Clusters for MED7:

    Mediator complex subunit 7
    Hs.279902  [show with all ESTs], Hs.744244  [show with all ESTs]
    Unigene Representative Sequences: BU902340, AK123613
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000286317(uc003lwm.4) ENST00000524289 ENST00000420343(uc010jik.3)


    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): MED7
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED7
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MED7:
    hsa-miR-499-5p hsa-miR-1322
    SwitchGear 3'UTR luciferase reporter plasmidMED7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED7
    OriGene shRNA RFP: MED7
    OriGene siRNA: MED7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED7
    Sirion Biotech Custom design and validation of potent shRNA sequences against MED7 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED7 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED7 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MED7 (NM_004270)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED7 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED7
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED7

    Additional cDNA sequence: 

    AF031383.1 AK123613.1 AK308393.1 BC006968.1 

    5 DOTS entries:

    DT.97839882  DT.444583  DT.91728563  DT.101963854  DT.100021417 

    24/183 AceView cDNA sequences (see all 183):

    CB047306 AA731165 BQ721490 AF104251 AV713281 AI239626 BI828956 BU902340 
    CB243286 BQ011916 AA722901 AK057543 AI767723 BC006968 AI371458 AK123613 
    BQ632043 AA195720 AV702955 AA938620 AW295321 N41875 BC005250 T17245 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MED7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAGATGTTT
    MED7 Expression
    About this image
    See MED7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MED7

    SOURCE GeneReport for Unigene clusters: Hs.279902 Hs.744244
        SABiosciences Custom PCR Arrays for MED7

    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED7
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED7
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MED7 gene from 9/28 species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med71 , 5 mediator complex subunit 71, 5 91.27(n)1
    97(a)1
      11 (27.88 cM)5
    662131  NM_001104530.11  NP_001098000.11 
     464369255 
    chicken
    (Gallus gallus)
    Aves LOC1008575751 mediator of RNA polymerase II transcription subunit more 80.93(n)
    89.52(a)
      100857575  XM_003642057.1  XP_003642105.1 
    lizard
    (Anolis carolinensis)
    Reptilia MED76
    --
    87(a)
    1 ↔ 1
    GL343205.1(2568242-2568934)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX844467.12   -- 77.8(n)    BX844467.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd99d122 wufd99d12 77.86(n)   326098  BC046018.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED71 Mediator complex subunit 7 55.18(n)
    56.31(a)
      41288  NM_169357.2  NP_731500.1 
    worm
    (Caenorhabditis elegans)
    Secernentea let-491 Protein LET-49 48.24(n)
    37.65(a)
      173353  NM_061184.2  NP_493585.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G035001 Mediator complex, subunit Med7 49.69(n)
    36.02(a)
      831822  NM_001085056.1  NP_001078525.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g06618001 hypothetical protein 49.49(n)
    39.39(a)
      4337290  NM_001060686.2  NP_001054151.1 


    ENSEMBL Gene Tree for MED7 (if available)
    TreeFam Gene Tree for MED7 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/127 NCBI SNPs in MED7 are shown (see all 127    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1154881411,2
    F--156565061(+) AAGAAA/GATGTA 2 -- ds50011Minor allele frequency- G:0.04WA 118
    rs360367511,2
    C--156565072(+) TAGCTG/AATGAC 2 -- ds50011Minor allele frequency- A:0.50NA 2
    rs360733521,2
    C--156565104(+) ATTAA-/TGTCTG 2 -- ds50011Minor allele frequency- T:0.00CSA 2
    rs2006358881,2
    --156565150(+) ACTGG-/AAAAAA 2 -- ds50010--------
    rs1464269391,2
    --156565202(+) GGATAA/GGGAGA 2 -- ds50010--------
    rs1491051331,2
    --156565221(+) AGCTAA/GTGGGT 2 -- ds50010--------
    rs37978511,2
    C,F,H--156565372(+) ATGTAG/TAGAGC 2 -- ds500122Minor allele frequency- T:0.24EA NS NA WA CSA 3797
    rs1811164201,2
    --156565429(+) TTTTCA/GAAGAC 2 -- ds50010--------
    rs1856118951,2
    --156565561(+) CACTCA/GTTTGT 2 -- ut310--------
    rs90071,2
    C,F,H--156565612(-) TTTCAA/GTTATG 2 -- ut3129Minor allele frequency- G:0.17MN NA NS EA CSA WA 3210

    HapMap Linkage Disequilibrium report for MED7 (156564423 - 156586030 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MED7: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MED7
    DNA2.0 Custom Variant and Variant Library Synthesis for MED7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MED7 for disorders           About GeneDecksing

    OMIM gene information: 605045    OMIM disorders: --

    2 diseases for MED7:    About MalaCards
    conjunctivitis    thyroiditis

    Human Genome Epidemiology (HuGE) Navigator: MED7 (1 document)

    Export disorders for MED7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MED7 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with MED7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. (PubMed id 9989412)1, 2, 3 Ryu S.... Tjian R. (1999)
    2. Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. (PubMed id 17709345)1, 2 Jakobs A.... Niedenthal R. (2007)
    3. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S....Conaway R.C. (2004)
    6. Composite co-activator ARC mediates chromatin-directed transcriptional activation. (PubMed id 10235267)1, 2 Naeaer A.M....Tjian R. (1999)
    7. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. (PubMed id 9671713)1, 2 Jiang Y.W.... Kornberg R.D. (1998)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9443 HGNC: 2378 AceView: CRSP9andMGC26988 Ensembl:ENSG00000155868 euGenes: HUgn9443
    ECgene: MED7 H-InvDB: MED7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MED7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MED7 gene:
    Search GeneIP for patents involving MED7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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