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Aliases for MED7 Gene

Aliases for MED7 Gene

  • Mediator Complex Subunit 7 2 3 4 5
  • Cofactor Required For Sp1 Transcriptional Activation, Subunit 9, 33kDa 2 3
  • RNA Polymerase Transcriptional Regulation Mediator Subunit 7 Homolog 3 4
  • Cofactor Required For Sp1 Transcriptional Activation Subunit 9 3 4
  • Activator-Recruited Cofactor 34 KDa Component 3 4
  • Transcriptional Coactivator CRSP33 3 4
  • CRSP Complex Subunit 9 3 4
  • ARC34 3 4
  • CRSP9 3 4
  • Cofactor Required For Sp1 Transcriptional Activation, Subunit 9 (33kD) 3
  • CRSP33 3
  • HMED7 4

External Ids for MED7 Gene

Previous HGNC Symbols for MED7 Gene

  • CRSP9

Previous GeneCards Identifiers for MED7 Gene

  • GC05M156495
  • GC05M156564
  • GC05M151653

Summaries for MED7 Gene

Entrez Gene Summary for MED7 Gene

  • The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MED7 Gene

MED7 (Mediator Complex Subunit 7) is a Protein Coding gene. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include transcription coactivator activity and RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED7 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED7 Gene

Genomics for MED7 Gene

Regulatory Elements for MED7 Gene

Genomic Location for MED7 Gene

Chromosome:
5
Start:
157,137,412 bp from pter
End:
157,159,019 bp from pter
Size:
21,608 bases
Orientation:
Minus strand

Genomic View for MED7 Gene

Genes around MED7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED7 Gene

Proteins for MED7 Gene

  • Protein details for MED7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43513-MED7_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 7
    Protein Accession:
    O43513

    Protein attributes for MED7 Gene

    Size:
    233 amino acids
    Molecular mass:
    27245 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

neXtProt entry for MED7 Gene

Proteomics data for MED7 Gene at MOPED

Post-translational modifications for MED7 Gene

Other Protein References for MED7 Gene

No data available for DME Specific Peptides for MED7 Gene

Domains & Families for MED7 Gene

Gene Families for MED7 Gene

Protein Domains for MED7 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O43513

UniProtKB/Swiss-Prot:

MED7_HUMAN :
  • Belongs to the Mediator complex subunit 7 family.
Family:
  • Belongs to the Mediator complex subunit 7 family.
genes like me logo Genes that share domains with MED7: view

Function for MED7 Gene

Molecular function for MED7 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IEA --
genes like me logo Genes that share ontologies with MED7: view
genes like me logo Genes that share phenotypes with MED7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED7 Gene

Localization for MED7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED7 Gene COMPARTMENTS Subcellular localization image for MED7 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MED7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005667 transcription factor complex IDA 9989412
GO:0016592 mediator complex IEA,IBA --
genes like me logo Genes that share ontologies with MED7: view

Pathways & Interactions for MED7 Gene

genes like me logo Genes that share pathways with MED7: view

Gene Ontology (GO) - Biological Process for MED7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA,IDA 9989412
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0019827 stem cell population maintenance IEA --
genes like me logo Genes that share ontologies with MED7: view

No data available for SIGNOR curated interactions for MED7 Gene

Drugs & Compounds for MED7 Gene

No Compound Related Data Available

Transcripts for MED7 Gene

Unigene Clusters for MED7 Gene

Mediator complex subunit 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED7 Gene

No ASD Table

Relevant External Links for MED7 Gene

GeneLoc Exon Structure for
MED7
ECgene alternative splicing isoforms for
MED7

Expression for MED7 Gene

mRNA expression in normal human tissues for MED7 Gene

Protein differential expression in normal tissues from HIPED for MED7 Gene

This gene is overexpressed in Fetal ovary (42.8) and Blymphocyte (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED7 Gene



SOURCE GeneReport for Unigene cluster for MED7 Gene Hs.279902

genes like me logo Genes that share expression patterns with MED7: view

Protein tissue co-expression partners for MED7 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MED7 Gene

Orthologs for MED7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MED7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED7 36
  • 100 (a)
OneToOne
MED7 35
  • 99.86 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia HAVCR2 36
  • 45 (a)
OneToOne
MED7 35
  • 92.56 (n)
  • 98.71 (a)
dog
(Canis familiaris)
Mammalia MED7 35
  • 93.56 (n)
  • 99.14 (a)
MED7 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med7 16
Med7 36
  • 97 (a)
OneToOne
Med7 35
  • 91.27 (n)
  • 97 (a)
oppossum
(Monodelphis domestica)
Mammalia MED7 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MED7 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med7 35
  • 91.27 (n)
  • 97.85 (a)
chicken
(Gallus gallus)
Aves MED7 36
  • 89 (a)
OneToOne
MED7 35
  • 80.72 (n)
  • 89.13 (a)
lizard
(Anolis carolinensis)
Reptilia MED7 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med7 35
  • 71.35 (n)
  • 81.58 (a)
Str.15008 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1621 35
zebrafish
(Danio rerio)
Actinopterygii med7 35
  • 70.43 (n)
  • 80 (a)
wufd99d12 35
med7 36
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta MED7_ANOGA 35
  • 57.48 (n)
  • 61.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta MED7 36
  • 52 (a)
OneToOne
MED7 35
  • 55.13 (n)
  • 55.77 (a)
worm
(Caenorhabditis elegans)
Secernentea let-49 36
  • 28 (a)
OneToOne
let-49 35
  • 48.24 (n)
  • 37.65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MED7 36
  • 30 (a)
OneToOne
MED7 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G03500 35
  • 49.38 (n)
  • 35.8 (a)
rice
(Oryza sativa)
Liliopsida Os04g0661800 35
  • 49.79 (n)
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for MED7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED7 Gene

ENSEMBL:
Gene Tree for MED7 (if available)
TreeFam:
Gene Tree for MED7 (if available)

Paralogs for MED7 Gene

(1) SIMAP similar genes for MED7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MED7: view

No data available for Paralogs for MED7 Gene

Variants for MED7 Gene

Sequence variations from dbSNP and Humsavar for MED7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs246877 -- 157,139,795(-) AGACA(A/G)CCTGT intron-variant
rs1043892 -- 157,138,706(-) TTTTT(A/C/G/T)CTTTT utr-variant-3-prime
rs1043894 -- 157,138,705(-) TTTTC(A/C/T)TTTTG utr-variant-3-prime
rs3734022 -- 157,139,159(+) AAAAG(A/G)TCCAA reference, synonymous-codon
rs34489636 -- 157,141,359(+) ACAGG(C/T)GTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED7 Gene

Variant ID Type Subtype PubMed ID
esv271175 CNV Insertion 20981092
esv272962 CNV Insertion 20981092

Variation tolerance for MED7 Gene

Residual Variation Intolerance Score: 62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MED7 Gene

HapMap Linkage Disequilibrium report
MED7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED7 Gene

Disorders for MED7 Gene

Relevant External Links for MED7

Genetic Association Database (GAD)
MED7
Human Genome Epidemiology (HuGE) Navigator
MED7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED7

No disorders were found for MED7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED7 Gene

Publications for MED7 Gene

  1. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. (PMID: 9989412) Ryu S. … Tjian R. (Nature 1999) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Subunit architecture and functional modular rearrangements of the transcriptional mediator complex. (PMID: 24882805) Tsai K.L. … Asturias F.J. (Cell 2014) 3
  4. Characterization of the influence of mediator complex in HIV-1 transcription. (PMID: 25100719) Ruiz A. … EstAc J.A. (J. Biol. Chem. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for MED7 Gene

Sources for MED7 Gene

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