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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MED7 Gene

protein-coding   GIFtS: 58
GCID: GC05M156564

Mediator Complex Subunit 7

(Previous names: cofactor required for Sp1 transcriptional activation, subunit...)
(Previous symbol: CRSP9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mediator Complex Subunit 71 2 3     CRSP Complex Subunit 92 3
CRSP91 2 3 5     RNA Polymerase Transcriptional Regulation Mediator Subunit 7 Homolog2 3
Cofactor Required For Sp1 Transcriptional Activation, Subunit 9, 33kDa1 2     CRSP332 5
Activator-Recruited Cofactor 34 KDa Component2 3     Cofactor Required For Sp1 Transcriptional Activation, Subunit 9 (33kD)2
Cofactor Required For Sp1 Transcriptional Activation Subunit 92 3     Mediator Of RNA Polymerase II Transcription Subunit 72
Transcriptional Coactivator CRSP332 3     hMED73
ARC342 3     

External Ids:    HGNC: 23781   Entrez Gene: 94432   Ensembl: ENSG000001558687   OMIM: 6050455   UniProtKB: O435133   

Export aliases for MED7 gene to outside databases

Previous GC identifers: GC05M156495 GC05M151653


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MED7 Gene:
The activation of gene transcription is a multistep process that is triggered by factors that recognize
transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation
by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required
for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein
is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which
interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and
cofactors. Two transcript variants encoding the same protein have been found for this gene. (provided by RefSeq,
Jul 2008)

GeneCards Summary for MED7 Gene: 
MED7 (mediator complex subunit 7) is a protein-coding gene. Diseases associated with MED7 include conjunctivitis, and thyroiditis, and among its related super-pathways are Gene Expression and Axon guidance. GO annotations related to this gene include RNA polymerase II transcription cofactor activity and transcription coactivator activity.

UniProtKB/Swiss-Prot: MED7_HUMAN, O43513
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MED7 gene promoter:
         AREB6   C/EBPbeta   AML1a   Nkx2-5   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED7 promoter sequence
   Search SABiosciences Chromatin IP Primers for MED7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q33.3

MED7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED7 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M156564:  view genomic region     (about GC identifiers)

Start:
156,564,423 bp from pter      End:
156,586,030 bp from pter
Size:
21,608 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MED7_HUMAN, O43513 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 7  
Size: 233 amino acids; 27245 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Subcellular location: Nucleus

Explore the universe of human proteins at neXtProt for MED7: NX_O43513

Explore proteomics data for MED7 at MOPED 

Post-translational modifications:

  • UniProtKB: Constitutively sumoylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43513

  • MED7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MED7 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001094286.1  NP_004261.1  

    ENSEMBL proteins: 
     ENSP00000286317   ENSP00000430746   ENSP00000401046  
    Reactome Protein details: O43513
    Human Recombinant Protein Products for MED7: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MED7
    OriGene Protein Over-expression Lysate for MED7
    OriGene MassSpec for MED7 
    OriGene Custom Protein Services for MED7
    GenScript Custom Purified and Recombinant Proteins Services for MED7
    Novus Biologicals MED7 Proteins
    Novus Biologicals MED7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for MED7
    Cloud-Clone Corp. Proteins for MED7 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IDA9989412
    GO:0016592mediator complex IEA--

    MED7 for ontologies           About GeneDecksing



    MED7 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Custom Antibody Services for MED7
    GenScript Custom Superior Antibodies Services for MED7
    Novus Biologicals MED7 Antibodies
    Abcam antibodies for MED7
    Cloud-Clone Corp. Antibodies for MED7 
    ThermoFisher Antibodies for MED7
    LSBio Antibodies in human, mouse, rat for MED7 

    Assay Products for MED7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED7 
    Cloud-Clone Corp. CLIAs for MED7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009244 Mediatior_Med7

    Graphical View of Domain Structure for InterPro Entry O43513

    ProtoNet protein and cluster: O43513

    1 Blocks protein domain: IPB009244 MED7

    UniProtKB/Swiss-Prot: MED7_HUMAN, O43513
    Similarity: Belongs to the Mediator complex subunit 7 family


    MED7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED7_HUMAN, O43513
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IEA--
    GO:0003713transcription coactivator activity TAS9989412
    GO:0005515protein binding IPI18391015
         
    MED7 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MED7:
     Decreased TP53 protein express  Decreased Tat-dependent transc  Decreased p24 protein expressi 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MED7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MED7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MED7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MED7 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED7
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MED7:
    hsa-miR-499-5p hsa-miR-1322
    SwitchGear 3'UTR luciferase reporter plasmidMED7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MED7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED7
    Sirion Biotech Customized adenovirus for overexpression of MED7

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MED7 (see all 14)
    OriGene ORF clones in mouse, rat for MED7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MED7 (NM_004270)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED7
    Sirion Biotech Customized lentivirus for stable overexpression of MED7 
                         Customized lentivirus expression plasmids for stable overexpression of MED7 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MED7
    Search LifeMap BioReagents cell lines for MED7
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MED7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    2Axon guidance
    Developmental Biology0.69
    3Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes1.00
    4Transcriptional Regulation of White Adipocyte Differentiation
    Transcriptional Regulation of White Adipocyte Differentiation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MED7
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    1 GeneGo (Thomson Reuters) Pathway for MED7
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    4        Reactome Pathways for MED7
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation
    Generic Transcription Pathway
    Gene Expression



    MED7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MED7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/129 Interacting proteins for MED7 (O435132, 3 ENSP000002863174) via UniProtKB, MINT, STRING, and/or I2D (see all 129)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000224145Q9C0193, ENSP000003982244I2D: score=1 STRING: ENSP00000398224
    ENSG00000137384Q9C0193I2D: score=1 
    ENSG00000227147Q9C0193I2D: score=1 
    ENSG00000233599Q9C0193I2D: score=1 
    ENSG00000235259Q9C0193I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA9989412
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0019827stem cell maintenance IEA--

    MED7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MED7

    Search CenterWatch for drugs/clinical trials and news about MED7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MED7 gene (2 alternative transcripts): 
    NM_001100816.1  NM_004270.4  

    Unigene Clusters for MED7:

    Mediator complex subunit 7
    Hs.279902  [show with all ESTs], Hs.744244  [show with all ESTs]
    Unigene Representative Sequences: BU902340, AK123613
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000286317(uc003lwm.4) ENST00000524289 ENST00000420343(uc010jik.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED7
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MED7:
    hsa-miR-499-5p hsa-miR-1322
    SwitchGear 3'UTR luciferase reporter plasmidMED7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MED7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED7
    Clone
    Products:
         
    OriGene clones in human, mouse for MED7 (see all 14)
    OriGene ORF clones in mouse, rat for MED7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MED7 (NM_004270)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED7
    Sirion Biotech Customized lentivirus for stable overexpression of MED7 
                         Customized lentivirus expression plasmids for stable overexpression of MED7 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MED7
    OriGene qSTAR qPCR primer pairs in human, mouse for MED7
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED7

    Additional mRNA sequence: 

    AF031383.1 AK123613.1 AK308393.1 BC006968.1 

    5 DOTS entries:

    DT.97839882  DT.444583  DT.91728563  DT.101963854  DT.100021417 

    24/183 AceView cDNA sequences (see all 183):

    AA644638 AI239626 AK123613 AI423955 CB047306 CF529528 BQ632043 BC006968 
    CK905893 AA722901 AL545660 CB243286 BU902340 AA459244 BM698562 CR541696 
    BQ631746 AA938620 BQ223113 AW295321 AA731165 BP370616 BG740750 AA195720 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MED7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGATGTTT
    MED7 Expression
    About this image


    See MED7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MED7

    SOURCE GeneReport for Unigene clusters: Hs.279902 Hs.744244
        SABiosciences Custom PCR Arrays for MED7
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MED7
    OriGene qSTAR qPCR primer pairs in human, mouse for MED7
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED7
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED7
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MED7 gene from 10/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med71 , 5 mediator complex subunit 71, 5 91.27(n)1
    97(a)1
      11 (27.88 cM)5
    662131  NM_001104530.11  NP_001098000.11 
     464369255 
    chicken
    (Gallus gallus)
    Aves LOC1008575751 mediator of RNA polymerase II transcription subunit more 80.93(n)
    89.52(a)
      100857575  XM_003642057.1  XP_003642105.1 
    lizard
    (Anolis carolinensis)
    Reptilia MED76
    Uncharacterized protein
    87(a)
    1 ↔ 1
    GL343205.1(2568242-2568934)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX844467.12   -- 77.8(n)    BX844467.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd99d122 wufd99d12 77.86(n)   326098  BC046018.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED71 Mediator complex subunit 7 55.18(n)
    56.31(a)
      41288  NM_169357.2  NP_731500.1 
    worm
    (Caenorhabditis elegans)
    Secernentea let-491 Protein LET-49 48.24(n)
    37.65(a)
      173353  NM_061184.2  NP_493585.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MED7(YOL135C)4 Subunit of the RNA polymerase II mediator complex; more   --   15(70044-69376) 853985  NP_014506.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G035001 Mediator complex, subunit Med7 49.69(n)
    36.02(a)
      831822  NM_001085056.1  NP_001078525.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g06618001 hypothetical protein 49.49(n)
    39.39(a)
      4337290  NM_001060686.2  NP_001054151.1 


    ENSEMBL Gene Tree for MED7 (if available)
    TreeFam Gene Tree for MED7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MED7 gene
    1 SIMAP similar gene for MED7 using alignment to 2 protein entries:     MED7_HUMAN (see all proteins):
    CRSP9

    MED7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/154 SNPs in MED7 are shown (see all 154)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1154881411,2
    C,F--156565061(+) AAGAAA/GATGTA 2 -- ds50011Minor allele frequency- G:0.04WA 118
    rs360367511,2
    C,F--156565072(+) TAGCTG/AATGAC 2 -- ds50011Minor allele frequency- A:0.50NA 2
    rs360733521,2
    C--156565104(+) ATTAA-/TGTCTG 2 -- ds50011Minor allele frequency- T:0.00CSA 2
    rs1121912621,2
    C--156565125(+) TGACCG/AAAGGA 2 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs2006358881,2
    C--156565150(+) ACTGG-/AAAAAA 2 -- ds50010--------
    rs1464269391,2
    --156565202(+) GGATAA/GGGAGA 2 -- ds50010--------
    rs1491051331,2
    --156565221(+) AGCTAA/GTGGGT 2 -- ds50010--------
    rs37978511,2
    C,F,H--156565372(+) ATGTAG/TAGAGC 2 -- ds500122Minor allele frequency- T:0.24EA NS NA WA CSA 3797
    rs1811164201,2
    --156565429(+) TTTTCA/GAAGAC 2 -- ds50010--------
    rs1856118951,2
    --156565561(+) CACTCA/GTTTGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for MED7 (156564423 - 156586030 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MED7:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv272962CNV Insertion20981092
    esv271175CNV Insertion20981092

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MED7
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605045    OMIM disorders: --

    2 diseases for MED7:    About MalaCards
    conjunctivitis    thyroiditis


    MED7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MED7
    Human Genome Epidemiology (HuGE) Navigator: MED7 (1 document)

    Export disorders for MED7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MED7 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with MED7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. (PubMed id 9989412)1, 2, 3 Ryu S.... Tjian R. (1999)
    2. Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. (PubMed id 17709345)1, 2 Jakobs A.... Niedenthal R. (2007)
    3. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S....Conaway R.C. (2004)
    6. Composite co-activator ARC mediates chromatin-directed transcriptional activation. (PubMed id 10235267)1, 2 Naeaer A.M....Tjian R. (1999)
    7. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. (PubMed id 9671713)1, 2 Jiang Y.W.... Kornberg R.D. (1998)
    8. Identification of the hypoxia-inducible factor 2a nucl ear interactome in melanoma cells reveals master proteins involved in melanoma d evelopment. (PubMed id 23275444)1 Steunou A.L....Nieto L. (2013)
    9. A conserved Mediator-CDK8 kinase module association re gulates Mediator-RNA polymerase II interaction. (PubMed id 23563140)1 Tsai K.L....Asturias F.J. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9443 HGNC: 2378 AceView: CRSP9andMGC26988 Ensembl:ENSG00000155868 euGenes: HUgn9443
    ECgene: MED7 H-InvDB: MED7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MED7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MED7 gene:
    Search GeneIP for patents involving MED7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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