Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MED6 Gene

Aliases for MED6 Gene

  • Mediator Complex Subunit 6 2 3 4
  • Activator-Recruited Cofactor 33 KDa Component 3 4
  • Renal Carcinoma Antigen NY-REN-28 3 4
  • ARC33 3 4
  • Mediator Of RNA Polymerase II Transcription, Subunit 6 Homolog (S. Cerevisiae) 2
  • Mediator Of RNA Polymerase II Transcription Subunit 6 3
  • CTD-2540L5.5 3
  • NY-REN-28 3
  • HMed6 4

External Ids for MED6 Gene

Previous GeneCards Identifiers for MED6 Gene

  • GC14M068555
  • GC14M064847
  • GC14M069040
  • GC14M070120
  • GC14M071050
  • GC14M051219

Summaries for MED6 Gene

GeneCards Summary for MED6 Gene

MED6 (Mediator Complex Subunit 6) is a Protein Coding gene. Among its related pathways are L1CAM interactions and Metabolism. GO annotations related to this gene include transcription factor binding and RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED6 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED6 Gene

Genomics for MED6 Gene

Regulatory Elements for MED6 Gene

Genomic Location for MED6 Gene

Start:
70,581,257 bp from pter
End:
70,600,690 bp from pter
Size:
19,434 bases
Orientation:
Minus strand

Genomic View for MED6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MED6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED6 Gene

Proteins for MED6 Gene

  • Protein details for MED6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75586-MED6_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 6
    Protein Accession:
    O75586
    Secondary Accessions:
    • B4DU17
    • B4E2P0
    • O15401
    • Q53FE3
    • Q53HJ3
    • Q6FHQ4
    • Q9BTH1
    • Q9UHL1

    Protein attributes for MED6 Gene

    Size:
    246 amino acids
    Molecular mass:
    28425 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CTNNB1 and GLI3.

    Alternative splice isoforms for MED6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED6 Gene

Proteomics data for MED6 Gene at MOPED

Post-translational modifications for MED6 Gene

  • Ubiquitination at Lys51
  • Modification sites at PhosphoSitePlus

Other Protein References for MED6 Gene

No data available for DME Specific Peptides for MED6 Gene

Domains for MED6 Gene

Protein Domains for MED6 Gene

Graphical View of Domain Structure for InterPro Entry

O75586

UniProtKB/Swiss-Prot:

MED6_HUMAN :
  • O75586
Family:
  • Belongs to the Mediator complex subunit 6 family.
genes like me logo Genes that share domains with MED6: view

No data available for Gene Families for MED6 Gene

Function for MED6 Gene

Molecular function for MED6 Gene

UniProtKB/Swiss-Prot Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IEA --
GO:0003677 DNA binding --
GO:0003713 transcription coactivator activity IDA 12037571
GO:0005515 protein binding IPI 14576168
GO:0008134 transcription factor binding IPI 17641689
genes like me logo Genes that share ontologies with MED6: view
genes like me logo Genes that share phenotypes with MED6: view

Animal Model Products

CRISPR Products

miRNA for MED6 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MED6 Gene

Localization for MED6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED6 Gene COMPARTMENTS Subcellular localization image for MED6 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MED6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10024883
GO:0005654 nucleoplasm TAS --
GO:0016020 membrane IDA 19946888
GO:0016592 mediator complex IMP 17641689
genes like me logo Genes that share ontologies with MED6: view

Pathways for MED6 Gene

genes like me logo Genes that share pathways with MED6: view

Gene Ontology (GO) - Biological Process for MED6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 10024883
GO:0006366 transcription from RNA polymerase II promoter --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
GO:0019827 stem cell maintenance --
genes like me logo Genes that share ontologies with MED6: view

Transcripts for MED6 Gene

Unigene Clusters for MED6 Gene

Mediator complex subunit 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MED6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED6 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for MED6 Gene

GeneLoc Exon Structure for
MED6
ECgene alternative splicing isoforms for
MED6

Expression for MED6 Gene

mRNA expression in normal human tissues for MED6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED6 Gene

SOURCE GeneReport for Unigene cluster for MED6 Gene Hs.497353

genes like me logo Genes that share expressions with MED6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MED6 Gene

Orthologs for MED6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MED6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED6 35
  • 99.74 (n)
  • 99.21 (a)
MED6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MED6 35
  • 93.09 (n)
  • 95.53 (a)
MED6 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED6 35
  • 93.5 (n)
  • 96.75 (a)
MED6 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med6 35
  • 91.45 (n)
  • 93.85 (a)
Med6 16
Med6 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MED6 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MED6 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med6 35
  • 91.87 (n)
  • 94.72 (a)
chicken
(Gallus gallus)
Aves MED6 35
  • 80.49 (n)
  • 88.62 (a)
MED6 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MED6 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med6 35
  • 75.75 (n)
  • 87.8 (a)
Str.1807 35
zebrafish
(Danio rerio)
Actinopterygii med6 35
  • 68.71 (n)
  • 78.78 (a)
med6 36
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta MED6_ANOGA 35
  • 56.67 (n)
  • 56.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta MED6 35
  • 51.19 (n)
  • 47.7 (a)
MED6 36
  • 45 (a)
OneToOne
Med6 37
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea mdt-6 35
  • 49.16 (n)
  • 39.73 (a)
mdt-6 36
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MED6 36
  • 20 (a)
OneToOne
MED6 38
thale cress
(Arabidopsis thaliana)
eudicotyledons MED6 35
  • 46.3 (n)
  • 38.46 (a)
rice
(Oryza sativa)
Liliopsida Os06g0217500 35
  • 47.24 (n)
  • 40.76 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9130 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToOne
Species with no ortholog for MED6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED6 Gene

ENSEMBL:
Gene Tree for MED6 (if available)
TreeFam:
Gene Tree for MED6 (if available)

Paralogs for MED6 Gene

Pseudogenes.org Pseudogenes for MED6 Gene

genes like me logo Genes that share paralogs with MED6: view

No data available for Paralogs for MED6 Gene

Variants for MED6 Gene

Sequence variations from dbSNP and Humsavar for MED6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1007402 -- 70,597,597(-) AAGGT(A/G)GCACT intron-variant
rs1137490 -- 70,592,595(-) ATCCC(A/G)GCACT intron-variant
rs1137491 -- 70,592,538(-) TCAGC(C/T)TGGGC intron-variant
rs1962311 -- 70,595,626(+) AGTAC(A/G)AGGCC intron-variant
rs1962312 -- 70,595,718(+) GGTGA(C/T)GCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED6 Gene

Variant ID Type Subtype PubMed ID
nsv819471 CNV Gain 19587683
nsv517712 CNV Loss 19592680

Relevant External Links for MED6 Gene

HapMap Linkage Disequilibrium report
MED6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED6 Gene

Disorders for MED6 Gene

Relevant External Links for MED6

Genetic Association Database (GAD)
MED6
Human Genome Epidemiology (HuGE) Navigator
MED6
genes like me logo Genes that share disorders with MED6: view

No data available for UniProtKB/Swiss-Prot for MED6 Gene

Publications for MED6 Gene

  1. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X. … Roeder R.G. (Mol. Cell 2005) 3 4
  2. A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans. (PMID: 9234719) Lee Y.C. … Kim Y.J. (Mol. Cell. Biol. 1997) 2 3
  3. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. (PMID: 9671713) Jiang Y.W. … Kornberg R.D. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3
  4. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. (PMID: 9734358) Sun X. … Reinberg D. (Mol. Cell 1998) 3 4
  5. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. (PMID: 10024883) Gu W. … Roeder R.G. (Mol. Cell 1999) 3 4

Products for MED6 Gene

Sources for MED6 Gene

Back to Top

Content