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MED6 Gene

protein-coding   GIFtS: 60
GCID: GC14M071050

Mediator Complex Subunit 6

(Previous names: mediator of RNA polymerase II transcription, subunit 6 homolog...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mediator Complex Subunit 61 2 3     CTD-2540L5.52
Activator-Recruited Cofactor 33 KDa Component2 3     NY-REN-282
Renal Carcinoma Antigen NY-REN-282 3     Mediator Of RNA Polymerase II Transcription Subunit 62
ARC332 3     hMed63
Mediator Of RNA Polymerase II Transcription, Subunit 6 Homolog (S.
Cerevisiae)1
     

External Ids:    HGNC: 199701   Entrez Gene: 100012   Ensembl: ENSG000001339977   OMIM: 6029845   UniProtKB: O755863   

Export aliases for MED6 gene to outside databases

Previous GC identifers: GC14M068555 GC14M064847 GC14M069040 GC14M070120 GC14M051219


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MED6 Gene:
MED6 (mediator complex subunit 6) is a protein-coding gene. GO annotations related to this gene include RNA polymerase II transcription cofactor activity and transcription factor binding.

UniProtKB/Swiss-Prot: MED6_HUMAN, O75586
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the MED6 gene promoter:
         HFH-3   HSF1 (long)   Tal-1beta   E47   YY1   FOXI1   POU2F1   POU2F1a   HSF1short   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED6 promoter sequence
   Search Chromatin IP Primers for MED6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MED6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.2   Ensembl cytogenetic band:  14q24.2   HGNC cytogenetic band: 14q24.1

MED6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED6 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M071050:  view genomic region     (about GC identifiers)

Start:
71,047,974 bp from pter      End:
71,067,384 bp from pter
Size:
19,411 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MED6_HUMAN, O75586 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 6  
Size: 246 amino acids; 28425 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CTNNB1 and
GLI3
Secondary accessions: O15401 Q53FE3 Q53HJ3 Q6FHQ4 Q9BTH1 Q9UHL1

Explore the universe of human proteins at neXtProt for MED6: NX_O75586

Explore proteomics data for MED6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys51
  • Modification sites at PhosphoSitePlus

  • See MED6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001271138.1  NP_001271139.1  NP_001271140.1  NP_005457.2  

    ENSEMBL proteins: 
     ENSP00000451684   ENSP00000256379   ENSP00000413343   ENSP00000394502  
    Reactome Protein details: O75586

    MED6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MED6
    OriGene Protein Over-expression Lysate for MED6
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MED6
    GenScript Custom Purified and Recombinant Proteins Services for MED6
    Novus Biologicals MED6 Protein
    Novus Biologicals MED6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MED6

     
    Search eBioscience for Proteins for MED6 

     
    antibodies-online proteins for MED6 (13 products) 

     
    antibodies-online peptides for MED6

    MED6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MED6
    Novus Biologicals MED6 Antibodies
    Abcam antibodies for MED6
    Cloud-Clone Corp. Antibodies for MED6
    Search ThermoFisher Antibodies for MED6
    antibodies-online antibodies for MED6 (36 products) 

    MED6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED6
    Cloud-Clone Corp. CLIAs for MED6
    Search eBioscience for ELISAs for MED6 
    antibodies-online kits for MED6 (18 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR016820 Mediator_Med6_met/pln
     IPR007018 Mediator_Med6

    Graphical View of Domain Structure for InterPro Entry O75586

    ProtoNet protein and cluster: O75586

    UniProtKB/Swiss-Prot: MED6_HUMAN, O75586
    Similarity: Belongs to the Mediator complex subunit 6 family


    Find genes that share domains with MED6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED6_HUMAN, O75586
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IEA--
    GO:0003677DNA binding IEA--
    GO:0003713transcription coactivator activity IDA12037571
    GO:0005515protein binding ----
    GO:0008134transcription factor binding IPI17641689
         
    Find genes that share ontologies with MED6           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for MED6:
     Decreased G3BP1 protein expres  Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 
     Decreased p24 protein expressi  Decreased viability with pacli  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MED6

    miRNA
    Products:
        
    miRTarBase miRNAs that target MED6:
    hsa-mir-199a-5p (MIRT004393), hsa-mir-98-5p (MIRT027503), hsa-mir-199a-3p (MIRT000781)

    Block miRNA regulation of human, mouse, rat MED6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MED6 (see all 17):
    hsa-miR-300 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3125 hsa-miR-3916 hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidMED6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MED6
    Predesigned siRNA for gene silencing in human, mouse, rat MED6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED6

    Clone
    Products:
         
    OriGene clones in human, mouse for MED6 (see all 9)
    OriGene ORF clones in mouse, rat for MED6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED6 (NM_005466)
    Sino Biological Human cDNA Clone for MED6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MED6
    Browse ESI BIO Cell Lines and PureStem Progenitors for MED6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MED6_HUMAN, O75586: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10024883
    GO:0005654nucleoplasm TAS--
    GO:0016592mediator complex IMP17641689

    Find genes that share ontologies with MED6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MED6 About    
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    4L1CAM interactions
    Developmental Biology0.63
    5Transcription Ligand Dependent Transcription of Retinoid Target genes
    Transcription Ligand Dependent Transcription of Retinoid Target genes


    Find genes that share SuperPaths with MED6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for MED6
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    3 Reactome Pathways for MED6
        Transcriptional regulation of white adipocyte differentiation
    Generic Transcription Pathway
    PPARA activates gene expression


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MED6
    Interactions:

        Search GeneGlobe Interaction Network for MED6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MED6 (O755862, 3 ENSP000002563794) via UniProtKB, MINT, STRING, and/or I2D (see all 167)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157962, 3, ENSP000002621604MINT-15456 I2D: score=4 STRING: ENSP00000262160
    ENSG00000227333Q96KQ73, ENSP000003973234I2D: score=1 STRING: ENSP00000397323
    EHMT2Q96KQ73I2D: score=1 
    ENSG00000206376Q96KQ73I2D: score=1 
    ENSG00000232045Q96KQ73I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS10024883
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0019827stem cell maintenance IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA12037571

    Find genes that share ontologies with MED6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MED6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MED6 gene (4 alternative transcripts): 
    NM_001284209.1  NM_001284210.1  NM_001284211.1  NM_005466.3  

    Unigene Cluster for MED6:

    Mediator complex subunit 6
    Hs.497353  [show with all ESTs]
    Unigene Representative Sequence: AK222587
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000554963 ENST00000256379(uc001xmf.3 uc010tti.2) ENST00000430055(uc010tth.2)
    ENST00000440435 ENST00000555296 ENST00000553611 ENST00000556044 ENST00000556495(uc001xmg.1)
    ENST00000554870(uc010ttj.2) ENST00000553523 ENST00000556423
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MED6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MED6 (see all 17):
    hsa-miR-300 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3125 hsa-miR-3916 hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidMED6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MED6
    Predesigned siRNA for gene silencing in human, mouse, rat MED6
    Clone
    Products:
         
    OriGene clones in human, mouse for MED6 (see all 9)
    OriGene ORF clones in mouse, rat for MED6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED6 (NM_005466)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MED6
    OriGene qSTAR qPCR primer pairs in human, mouse for MED6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED6
      QuantiTect SYBR Green Assays in human, mouse, rat MED6
      QuantiFast Probe-based Assays in human, mouse, rat MED6

    Additional mRNA sequence: 

    AF074723.1 AF155104.1 AK222587.1 AK223346.1 AK290647.1 AK300417.1 AK300460.1 AK304361.1 
    BC004106.2 BT006831.1 CR541697.1 U78082.1 

    9 DOTS entries:

    DT.407540  DT.75142928  DT.92423899  DT.120792786  DT.100765107  DT.100023796  DT.100762064  DT.75101240 
    DT.91953847 

    Selected AceView cDNA sequences (see all 104):

    BM800780 CB139421 AA613346 AA305926 AI621182 BQ641743 BM832492 BM808773 
    BP369326 CB138000 R99951 BC004106 BM552230 BU192589 NM_005466 BE891802 
    CR608591 BM449752 BQ433395 BP379959 BM981244 AI564038 BE909461 BM791166 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MED6 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7
    SP1:        -                       -     -           -     -           -               
    SP2:                                -     -           -                 -               
    SP3:        -                       -     -           -     -                           
    SP4:        -                       -     -                                             
    SP5:        -                                                                           


    ECgene alternative splicing isoforms for MED6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MED6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTACTGGTA
    MED6 Expression
    About this image

    MED6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MED6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.497353
        Custom PCR Arrays for MED6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MED6
    OriGene qSTAR qPCR primer pairs in human, mouse for MED6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED6
    QuantiTect SYBR Green Assays in human, mouse, rat MED6
    QuantiFast Probe-based Assays in human, mouse, rat MED6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MED6 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med61 , 5 mediator of RNA polymerase II transcription, subunit more5
    mediator complex subunit 61
    91.45(n)1
    93.85(a)1
      12 (37.80 cM)5
    697921  NM_027213.21  NP_081489.21 
     815735575 
    chicken
    (Gallus gallus)
    Aves MED61 mediator complex subunit 6 80.49(n)
    88.62(a)
      426282  NM_001159425.1  NP_001152897.1 
    lizard
    (Anolis carolinensis)
    Reptilia MED66
    mediator complex subunit 6
    87(a)
    1 ↔ 1
    GL343753.1(84100-119256)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.18072 Transcribed sequence with strong similarity to protein more 79.91(n)    137732606 
    zebrafish
    (Danio rerio)
    Actinopterygii med61 mediator complex subunit 6 68.71(n)
    78.78(a)
      415174  NM_001002084.1  NP_001002084.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Med63
    MED61
    transcription from Pol II promoter RNA
    polymerase more3
    Mediator complex subunit 61
    54(a)3
    51.19(n)1
    47.7(a)1
      85E83
    447281  NM_169310.21  NP_731403.21 
    worm
    (Caenorhabditis elegans)
    Secernentea mdt-61 mdt-6 49.16(n)
    39.73(a)
      179091  NM_072390.4  NP_504791.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MED6(YHR058C)4 Subunit of the RNA polymerase II mediator complex; more   --   8(219884-218997) 856455  NP_011925.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MED61 MED6 46.3(n)
    38.46(a)
      821689  NM_113030.4  NP_188772.2 
    rice
    (Oryza sativa)
    Liliopsida Os06g02175001 Os06g0217500 47.24(n)
    40.76(a)
      4340496  NM_001063685.1  NP_001057150.1 


    ENSEMBL Gene Tree for MED6 (if available)
    TreeFam Gene Tree for MED6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MED6 gene

    Find genes that share paralogs with MED6           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for MED6
    PGOHUM00000238574 PGOHUM00000237733


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MED6 (see all 434)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894061251,2
    --71050476(+) AGATAC/TAATAA 1 -- ds50010--------
    rs1494902651,2
    --71050480(+) ATAATA/GAAGTA 1 -- ds50010--------
    rs1814482741,2
    --71050495(+) TGTACA/GAAAGG 1 -- ds50010--------
    rs1169662871,2
    F--71050509(+) GATTAA/CAGTAC 1 -- ds50011Minor allele frequency- C:0.01NA 120
    rs727197621,2
    C,F--71050546(+) AGCACA/GCTCAG 1 -- ds50011Minor allele frequency- G:0.04NA 120
    rs783482291,2
    --71050561(+) CTTGCC/GATGAG 1 -- ds50010--------
    rs766159241,2
    C,F--71050588(+) AGGGAC/TTTTGC 1 -- ds50011Minor allele frequency- T:0.08EA 120
    rs1388397441,2
    --71050613(+) CAAGAA/TGGCCC 1 -- ds50010--------
    rs592339241,2
    C--71050660(+) CCTCCA/GTAACT 1 -- ds50014Minor allele frequency- G:0.26WA NA EA 360
    rs118447311,2
    C,F,H--71050715(+) CTACAC/TACAGA 1 -- ds5001 ese37Minor allele frequency- T:0.11NS EA WA 658

    HapMap Linkage Disequilibrium report for MED6 (71047974 - 71067384 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MED6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv517712CNV Loss19592680
    nsv819471CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MED6
    DNA2.0 Custom Variant and Variant Library Synthesis for MED6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602984    OMIM disorders: --


    Find genes that share disorders with MED6           About GenesLikeMe

    Genetic Association Database (GAD): MED6
    Human Genome Epidemiology (HuGE) Navigator: MED6 (1 document)

    Export disorders for MED6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MED6 gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with MED6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (Mol. Cell 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S.... Conaway R.C. (Mol. Cell 2004)
    4. The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. (PubMed id 11867769)1, 2 Kang Y.K.... Roeder R.G. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. TFIIH is negatively regulated by cdk8-containing mediator complexes. (PubMed id 10993082)1, 2 Akoulitchev S.... Reinberg D. (Nature 2000)
    6. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. (PubMed id 10024883)1, 2 Gu W.... Roeder R.G. (Mol. Cell 1999)
    7. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (Int. J. Cancer 1999)
    8. Composite co-activator ARC mediates chromatin-directed transcriptional activation. (PubMed id 10235267)1, 2 Naeaer A.M....Tjian R. (Nature 1999)
    9. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. (PubMed id 9671713)1, 3 Jiang Y.W.... Kornberg R.D. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    10. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. (PubMed id 9734358)1, 2 Sun X.... Reinberg D. (Mol. Cell 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10001 HGNC: 19970 AceView: MED6 Ensembl:ENSG00000133997 euGenes: HUgn10001
    ECgene: MED6 H-InvDB: MED6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MED6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MED6 gene:
    Search GeneIP for patents involving MED6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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