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Aliases for MED6 Gene

Aliases for MED6 Gene

  • Mediator Complex Subunit 6 2 3 4 5
  • Activator-Recruited Cofactor 33 KDa Component 3 4
  • Renal Carcinoma Antigen NY-REN-28 3 4
  • ARC33 3 4
  • Mediator Of RNA Polymerase II Transcription, Subunit 6 Homolog (S. Cerevisiae) 2
  • Mediator Of RNA Polymerase II Transcription Subunit 6 3
  • CTD-2540L5.5 3
  • NY-REN-28 3
  • HMed6 4

External Ids for MED6 Gene

Previous GeneCards Identifiers for MED6 Gene

  • GC14M068555
  • GC14M064847
  • GC14M069040
  • GC14M070120
  • GC14M071050
  • GC14M051219

Summaries for MED6 Gene

GeneCards Summary for MED6 Gene

MED6 (Mediator Complex Subunit 6) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Gene Expression. GO annotations related to this gene include transcription factor binding and RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED6 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED6 Gene

Genomics for MED6 Gene

Regulatory Elements for MED6 Gene

Enhancers for MED6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G070358 1.2 ENCODE 28.7 +241.2 241226 1.8 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 MED6 COX16 PTTG4P RPL7AP6 SUSD6 KRT18P7 ERH SLC8A3 PIR53064
GH14G070652 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -60.6 -60551 17.5 HDGF FOXA2 PKNOX1 ARNT WRNIP1 SIN3A ZBTB7B YY1 ETS1 TCF12 TTC9 MED6 SYNJ2BP GC14P070671 GC14P070643
GH14G071140 1.5 Ensembl ENCODE dbSUPER 10.9 -542.6 -542609 4.8 ZFP64 GATA2 CBX5 FOS REST ZNF623 TBX21 ZNF518A MIER3 SMARCA4 PCNX1 ADAM20 SIPA1L1 MED6 ADAM21 ADAM20P1 ENSG00000269927 ENSG00000259907
GH14G071335 1.5 Ensembl ENCODE dbSUPER 10.9 -737.8 -737811 7.0 PKNOX1 FOXA2 ZFP64 ARID4B FEZF1 YY1 TCF12 ZNF766 GATA2 FOS ADAM20 SNORD56B MED6 ADAM21 ADAM20P1 LOC102724015 SIPA1L1 GC14M071331 GC14M071365
GH14G070645 1 Ensembl ENCODE dbSUPER 10.6 -46.1 -46081 2.5 JUND FOS MLLT1 MED6 TTC9 GC14P070643 GC14P070671
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MED6 on UCSC Golden Path with GeneCards custom track

Promoters for MED6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000070320 190 1801 FOXA2 ATF1 WRNIP1 ARID4B SIN3A DMAP1 BRCA1 YY1 ETS1 ZNF766

Genomic Location for MED6 Gene

Chromosome:
14
Start:
70,581,257 bp from pter
End:
70,600,690 bp from pter
Size:
19,434 bases
Orientation:
Minus strand

Genomic View for MED6 Gene

Genes around MED6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED6 Gene

Proteins for MED6 Gene

  • Protein details for MED6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75586-MED6_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 6
    Protein Accession:
    O75586
    Secondary Accessions:
    • B4DU17
    • B4E2P0
    • O15401
    • Q53FE3
    • Q53HJ3
    • Q6FHQ4
    • Q9BTH1
    • Q9UHL1

    Protein attributes for MED6 Gene

    Size:
    246 amino acids
    Molecular mass:
    28425 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CTNNB1 and GLI3.

    Alternative splice isoforms for MED6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED6 Gene

Post-translational modifications for MED6 Gene

  • Ubiquitination at Lys51
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MED6 Gene

Domains & Families for MED6 Gene

Gene Families for MED6 Gene

Protein Domains for MED6 Gene

Graphical View of Domain Structure for InterPro Entry

O75586

UniProtKB/Swiss-Prot:

MED6_HUMAN :
  • Belongs to the Mediator complex subunit 6 family.
Family:
  • Belongs to the Mediator complex subunit 6 family.
genes like me logo Genes that share domains with MED6: view

Function for MED6 Gene

Molecular function for MED6 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IEA --
GO:0001128 RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly IBA --
GO:0003713 transcription coactivator activity IDA 12037571
GO:0005515 protein binding IPI 14576168
GO:0008134 transcription factor binding IPI 17641689
genes like me logo Genes that share ontologies with MED6: view
genes like me logo Genes that share phenotypes with MED6: view

Animal Model Products

miRNA for MED6 Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED6 Gene

Localization for MED6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MED6 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MED6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IEA 10024883
GO:0005654 nucleoplasm TAS,IDA --
GO:0016020 membrane IDA 19946888
GO:0016592 mediator complex IMP,IEA 17641689
GO:0070847 core mediator complex IBA --
genes like me logo Genes that share ontologies with MED6: view

Pathways & Interactions for MED6 Gene

genes like me logo Genes that share pathways with MED6: view

Gene Ontology (GO) - Biological Process for MED6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA,TAS 10024883
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MED6: view

No data available for SIGNOR curated interactions for MED6 Gene

Drugs & Compounds for MED6 Gene

No Compound Related Data Available

Transcripts for MED6 Gene

Unigene Clusters for MED6 Gene

Mediator complex subunit 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED6 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for MED6 Gene

GeneLoc Exon Structure for
MED6
ECgene alternative splicing isoforms for
MED6

Expression for MED6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MED6 Gene

Protein differential expression in normal tissues from HIPED for MED6 Gene

This gene is overexpressed in Breast (42.2) and CD8 Tcells (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MED6 Gene



Protein tissue co-expression partners for MED6 Gene

NURSA nuclear receptor signaling pathways regulating expression of MED6 Gene:

MED6

SOURCE GeneReport for Unigene cluster for MED6 Gene:

Hs.497353

Evidence on tissue expression from TISSUES for MED6 Gene

  • Lung(4.3)
  • Heart(4.2)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with MED6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED6 Gene

Orthologs for MED6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MED6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED6 34 35
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia MED6 34 35
  • 93.5 (n)
cow
(Bos Taurus)
Mammalia MED6 34 35
  • 93.09 (n)
oppossum
(Monodelphis domestica)
Mammalia MED6 35
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med6 34
  • 91.87 (n)
mouse
(Mus musculus)
Mammalia Med6 34 16 35
  • 91.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MED6 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED6 34 35
  • 80.49 (n)
lizard
(Anolis carolinensis)
Reptilia MED6 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med6 34
  • 75.75 (n)
Str.1807 34
zebrafish
(Danio rerio)
Actinopterygii med6 34 35
  • 68.71 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta MED6_ANOGA 34
  • 56.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta Med6 36
  • 54 (a)
MED6 34 35
  • 51.19 (n)
worm
(Caenorhabditis elegans)
Secernentea mdt-6 34 35
  • 49.16 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MED6 35 37
  • 20 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons MED6 34
  • 46.3 (n)
rice
(Oryza sativa)
Liliopsida Os06g0217500 34
  • 47.24 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 54 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9130 34
Species where no ortholog for MED6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED6 Gene

ENSEMBL:
Gene Tree for MED6 (if available)
TreeFam:
Gene Tree for MED6 (if available)

Paralogs for MED6 Gene

Pseudogenes.org Pseudogenes for MED6 Gene

genes like me logo Genes that share paralogs with MED6: view

No data available for Paralogs for MED6 Gene

Variants for MED6 Gene

Sequence variations from dbSNP and Humsavar for MED6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000155325 -- 70,587,394(+) CCCCA(A/G)CAAAG intron-variant
rs1000340442 -- 70,592,274(+) AGGAC(C/T)TGGAG intron-variant
rs1000766839 -- 70,585,719(+) GACCT(C/T)ATTTC intron-variant
rs1000807573 -- 70,599,830(+) AAGAC(A/G)CGTAT intron-variant
rs1000891915 -- 70,582,903(+) AATGC(A/G)TGGCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MED6 Gene

Variant ID Type Subtype PubMed ID
esv29658 CNV loss 19812545
esv3634863 CNV loss 21293372
nsv517712 CNV loss 19592680
nsv819471 CNV gain 19587683
nsv974351 CNV duplication 23825009

Variation tolerance for MED6 Gene

Residual Variation Intolerance Score: 28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MED6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED6 Gene

Disorders for MED6 Gene

Relevant External Links for MED6

Genetic Association Database (GAD)
MED6
Human Genome Epidemiology (HuGE) Navigator
MED6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED6

No disorders were found for MED6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED6 Gene

Publications for MED6 Gene

  1. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X. … Roeder R.G. (Mol. Cell 2005) 3 4 64
  2. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. (PMID: 11867769) Kang Y.K. … Roeder R.G. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 64
  5. TFIIH is negatively regulated by cdk8-containing mediator complexes. (PMID: 10993082) Akoulitchev S. … Reinberg D. (Nature 2000) 3 4 64

Products for MED6 Gene

Sources for MED6 Gene

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