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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MED6 Gene

protein-coding   GIFtS: 57
GCID: GC14M071050

mediator complex subunit 6

(Previous names: mediator of RNA polymerase II transcription, subunit 6...)
 Explore 6 diseases affiliated with
MED6 via our new
 Human Malady Compendium 
Biological research products
for MED6
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mediator Complex Subunit 61 2 3     HMed61
NY-REN-281 2     Mediator Of RNA Polymerase II Transcription, Subunit 6 Homolog (S. Cerevisiae)1
Activator-Recruited Cofactor 33 KDa Component2 3     Mediator Of RNA Polymerase II Transcription Subunit 62
Renal Carcinoma Antigen NY-REN-282 3     Mediator Of RNA Polymerase II Transcription, Subunit 6 Homolog2
ARC332 3     

External Ids:    HGNC: 199701   Entrez Gene: 100012   Ensembl: ENSG000001339977   OMIM: 6029845   UniProtKB: O755863   

Export aliases for MED6 gene to outside databases

Previous GC identifers: GC14M068555 GC14M064847 GC14M069040 GC14M070120 GC14M051219


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MED6_HUMAN, O75586
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED6


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MED6 gene promoter:
         HFH-3   HSF1 (long)   Tal-1beta   E47   YY1   FOXI1   POU2F1   POU2F1a   HSF1short   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED6 promoter sequence
   Search SABiosciences Chromatin IP Primers for MED6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.2   Ensembl cytogenetic band:  14q24.2   HGNC cytogenetic band: 14q24.1

MED6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED6 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M071050:  view genomic region     (about GC identifiers)

Start:
71,047,974 bp from pter      End:
71,067,384 bp from pter
Size:
19,411 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MED6_HUMAN, O75586 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 6  
Size: 246 amino acids; 28425 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in
supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct
subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CTNNB1 and GLI3
Subcellular location: Nucleus
Secondary accessions: O15401 Q53FE3 Q53HJ3 Q6FHQ4 Q9BTH1 Q9UHL1

Explore the universe of human proteins at neXtProt for MED6: NX_O75586

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75586

  • MED6 Protein expression data from MOPED and PaxDb:    About this image 
    MED6 Protein Expression
    REFSEQ proteins: NP_005457.2  
    ENSEMBL proteins: 
     ENSP00000451684   ENSP00000256379   ENSP00000413343   ENSP00000394502  
    Reactome Protein details: O75586
    Human Recombinant Protein Products for MED6: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: MED6
    OriGene Custom Protein Services for MED6 
    GenScript Custom Purified and Recombinant Proteins Services for MED6
    Novus Biologicals MED6 Protein
    Novus Biologicals MED6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MED6

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10024883
    GO:0005654nucleoplasm TAS--
    GO:0016592mediator complex IMP17641689

    MED6 for ontologies           About GeneDecksing



    MED6 Antibody Products: 
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    Novus Biologicals MED6 Antibodies
    Abcam antibodies for MED6 
    Uscn Antibodies for MED6
    Search ThermoFisher Antibodies for MED6

    Assay Products for MED6: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
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    Uscn ELISAs and CLIAs for MED6


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MED6 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR016820 Mediator_Med6_met/pln
     IPR007018 Mediator_Med6

    Graphical View of Domain Structure for InterPro Entry O75586

    ProtoNet protein and cluster: O75586

    UniProtKB/Swiss-Prot: MED6_HUMAN, O75586
    Similarity: Belongs to the Mediator complex subunit 6 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED6_HUMAN, O75586
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
    polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
    proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
    interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
    with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IEA--
    GO:0003677DNA binding IEA--
    GO:0003713transcription coactivator activity IDA12037571
    GO:0005515protein binding ----
    GO:0008134transcription factor binding IPI17641689
         
    MED6 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for MED6:
     Decreased G3BP1 protein expres  Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 
     Decreased p24 protein expressi  Decreased viability with pacli  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MED6 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MED6:
    hsa-mir-199a-5p (MIRT004393), hsa-mir-199b-3p (MIRT004394)

    OriGene 3'-UTR Clone: MED6
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED6
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate MED6 (see all 17):
    hsa-miR-300 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3125 hsa-miR-3916 hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidMED6 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED6 (see all 7)
    OriGene shRNA RFP: MED6
    OriGene siRNA: MED6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED6
    Sirion Biotech Custom design and validation of potent shRNA sequences against MED6 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of MED6 
    Sirion Biotech Customized adenovirus for potent knockdown of MED6

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED6 (see all 3)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MED6 (NM_005466)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED6 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MED6
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    Sirion Biotech Customized inducible overexpressing cell line services for MED6

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46
    2HIV Infection
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes0.28
    Transcription_Ligand-Dependent Transcription of Retinoid-Target genes0.28
    3Transcriptional Regulation of White Adipocyte Differentiation
    Transcriptional Regulation of White Adipocyte Differentiation1.00
    4Axon guidance
    Developmental Biology0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for MED6
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    1 GeneGo (Thomson Reuters) Pathway for MED6
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    4        Reactome Pathways for MED6
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation
    Generic Transcription Pathway
    Gene Expression



    MED6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MED6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/120 Interacting proteins for MED6 (O755862, 3 ENSP000002563794) via UniProtKB, MINT, STRING, and/or I2D (see all 120)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157962, 3, ENSP000002621604MINT-15456 I2D: score=4 STRING: ENSP00000262160
    SMAD1Q157972, 3, ENSP000003057694MINT-17337 I2D: score=4 STRING: ENSP00000305769
    RARAP102763, ENSP000002540664I2D: score=4 STRING: ENSP00000254066
    MED28Q9H2043, ENSP000002373804I2D: score=3 STRING: ENSP00000237380
    MED30Q96HR33, ENSP000002973474I2D: score=3 STRING: ENSP00000297347
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS10024883
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0019827stem cell maintenance IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA12037571

    MED6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MED6
    Search CenterWatch for drugs/clinical trials and news about MED6 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MED6 gene: 
    NM_005466.2  

    Unigene Cluster for MED6:

    Mediator complex subunit 6
    Hs.497353  [show with all ESTs]
    Unigene Representative Sequence: AK222587
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000554963 ENST00000256379(uc001xmf.3 uc010tti.2) ENST00000430055(uc010tth.2)
    ENST00000440435 ENST00000555296 ENST00000553611 ENST00000556044 ENST00000556495(uc001xmg.1)
    ENST00000554870(uc010ttj.2) ENST00000553523 ENST00000556423

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: MED6
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED6
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate MED6 (see all 17):
    hsa-miR-300 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3125 hsa-miR-3916 hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidMED6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED6 (see all 7)
    OriGene shRNA RFP: MED6
    OriGene siRNA: MED6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED6
    Sirion Biotech Custom design and validation of potent shRNA sequences against MED6 
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED6 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED6 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MED6 (NM_005466)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED6 
    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED6

    Additional cDNA sequence: 

    AF074723.1 AF155104.1 AK222587.1 AK223346.1 AK290647.1 AK300417.1 AK300460.1 AK304361.1 
    BC004106.2 BT006831.1 CR541697.1 U78082.1 

    9 DOTS entries:

    DT.407540  DT.75142928  DT.92423899  DT.120792786  DT.100765107  DT.100023796  DT.100762064  DT.75101240 
    DT.91953847 

    24/104 AceView cDNA sequences (see all 104):

    BQ641743 BP369326 BM832492 CR608591 BC004106 BE909461 BE891802 BP350015 
    NM_005466 CB138000 BU957680 AI564038 BM800780 AA305926 BM449752 BM981244 
    BP379959 BM999935 BM791166 R99951 BM808773 CB139421 BM552230 BU192589 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MED6 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7
    SP1:        -                       -     -           -     -           -               
    SP2:                                -     -           -                 -               
    SP3:        -                       -     -           -     -                           
    SP4:        -                       -     -                                             
    SP5:        -                                                                           


    ECgene alternative splicing isoforms for MED6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MED6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTACTGGTA
    MED6 Expression
    About this image
    See MED6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MED6

    SOURCE GeneReport for Unigene cluster: Hs.497353
        SABiosciences Custom PCR Arrays for MED6

    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MED6 gene from 9/28 species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med61 , 5 mediator of RNA polymerase II transcription, subunit more1, 5 91.45(n)1
    93.85(a)1
      12 (37.80 cM)5
    697921  NM_027213.21  NP_081489.21 
     815735575 
    chicken
    (Gallus gallus)
    Aves MED61 mediator complex subunit 6 80.49(n)
    88.62(a)
      426282  NM_001159425.1  NP_001152897.1 
    lizard
    (Anolis carolinensis)
    Reptilia MED66
    --
    83(a)
    1 ↔ 1
    GL343753.1(88625-96905)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.18072 Transcribed sequence with strong similarity to protein more 79.91(n)    137732606 
    zebrafish
    (Danio rerio)
    Actinopterygii med61 mediator complex subunit 6 68.84(n)
    78.78(a)
      415174  NM_001002084.1  NP_001002084.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Med63
    MED61
    transcription from Pol II promoter RNA
    polymerase more3
    Mediator complex subunit 61
    54(a)3
    51.19(n)1
    47.7(a)1
      85E83
    447281  NM_169310.21  NP_731403.21 
    worm
    (Caenorhabditis elegans)
    Secernentea mdt-61 Protein MDT-6 49.46(n)
    40(a)
      179091  NM_072390.3  NP_504791.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MED61 RNA polymerase transcriptional regulation mediator-like more 46.06(n)
    38.18(a)
      821689  NM_113030.4  NP_188772.2 
    rice
    (Oryza sativa)
    Liliopsida Os06g02175001 hypothetical protein 46.04(n)
    39.11(a)
      4340496  NM_001063685.1  NP_001057150.1 


    ENSEMBL Gene Tree for MED6 (if available)
    TreeFam Gene Tree for MED6 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MED6 gene

    MED6 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MED6
    PGOHUM00000238574 PGOHUM00000237733


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/373 NCBI SNPs in MED6 are shown (see all 373    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894061251,2
    --71050476(+) AGATAC/TAATAA 1 -- ds50010--------
    rs1494902651,2
    --71050480(+) ATAATA/GAAGTA 1 -- ds50010--------
    rs1814482741,2
    --71050495(+) TGTACA/GAAAGG 1 -- ds50010--------
    rs1169662871,2
    --71050509(+) GATTAA/CAGTAC 1 -- ds50011Minor allele frequency- C:0.01NA 120
    rs727197621,2
    C,F--71050546(+) AGCACA/GCTCAG 1 -- ds50011Minor allele frequency- G:0.04NA 120
    rs783482291,2
    --71050561(+) CTTGCC/GATGAG 1 -- ds50010--------
    rs766159241,2
    F--71050588(+) AGGGAC/TTTTGC 1 -- ds50011Minor allele frequency- T:0.08EA 120
    rs1388397441,2
    --71050613(+) CAAGAA/TGGCCC 1 -- ds50010--------
    rs592339241,2
    C--71050660(+) CCTCCA/GTAACT 1 -- ds50014Minor allele frequency- G:0.26WA NA EA 360
    rs118447311,2
    C,F,H--71050715(+) CTACAC/TACAGA 1 -- ds5001 ese37Minor allele frequency- T:0.11NS EA WA 658

    HapMap Linkage Disequilibrium report for MED6 (71047974 - 71067384 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for MED6
         2 Indels: 58684 49406

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MED6 for disorders           About GeneDecksing

    OMIM gene information: 602984    OMIM disorders: --

    6 diseases for MED6:    About MalaCards
    renal carcinoma    carcinoma    spondylolysis    renal cell carcinoma
    cholesterol    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: MED6 (1 document)

    Export disorders for MED6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MED6 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with MED6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S....Conaway R.C. (2004)
    4. The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. (PubMed id 11867769)1, 2 Kang Y.K.... Roeder R.G. (2002)
    5. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. (PubMed id 10024883)1, 2 Gu W.... Roeder R.G. (1999)
    6. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (1999)
    7. Composite co-activator ARC mediates chromatin-directed transcriptional activation. (PubMed id 10235267)1, 2 Naeaer A.M....Tjian R. (1999)
    8. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. (PubMed id 9671713)1, 3 Jiang Y.W.... Kornberg R.D. (1998)
    9. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. (PubMed id 9734358)1, 2 Sun X.... Reinberg D. (1998)
    10. A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans. (PubMed id 9234719)1, 3 Lee Y.C....Kim Y.J. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10001 HGNC: 19970 AceView: MED6 Ensembl:ENSG00000133997 euGenes: HUgn10001
    ECgene: MED6 H-InvDB: MED6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MED6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MED6 gene:
    Search GeneIP for patents involving MED6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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