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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MED6 Gene

protein-coding   GIFtS: 60
GCID: GC14M071050

Mediator Complex Subunit 6

(Previous names: mediator of RNA polymerase II transcription, subunit 6 homolog...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mediator Complex Subunit 61 2 3     Mediator Of RNA Polymerase II Transcription, Subunit 6 Homolog (S.
Cerevisiae)1
Activator-Recruited Cofactor 33 KDa Component2 3     NY-REN-282
Renal Carcinoma Antigen NY-REN-282 3     Mediator Of RNA Polymerase II Transcription Subunit 62
ARC332 3     hMed63

External Ids:    HGNC: 199701   Entrez Gene: 100012   Ensembl: ENSG000001339977   OMIM: 6029845   UniProtKB: O755863   

Export aliases for MED6 gene to outside databases

Previous GC identifers: GC14M068555 GC14M064847 GC14M069040 GC14M070120 GC14M051219


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MED6 Gene: 
MED6 (mediator complex subunit 6) is a protein-coding gene. Diseases associated with MED6 include spondylolysis, and renal cell carcinoma, and among its related super-pathways are Gene Expression and Axon guidance. GO annotations related to this gene include RNA polymerase II transcription cofactor activity and transcription factor binding.

UniProtKB/Swiss-Prot: MED6_HUMAN, O75586
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MED6 gene promoter:
         HFH-3   HSF1 (long)   Tal-1beta   E47   YY1   FOXI1   POU2F1   POU2F1a   HSF1short   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED6 promoter sequence
   Search SABiosciences Chromatin IP Primers for MED6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.2   Ensembl cytogenetic band:  14q24.2   HGNC cytogenetic band: 14q24.1

MED6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED6 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M071050:  view genomic region     (about GC identifiers)

Start:
71,047,974 bp from pter      End:
71,067,384 bp from pter
Size:
19,411 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MED6_HUMAN, O75586 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 6  
Size: 246 amino acids; 28425 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CTNNB1 and
GLI3
Subcellular location: Nucleus
Secondary accessions: O15401 Q53FE3 Q53HJ3 Q6FHQ4 Q9BTH1 Q9UHL1

Explore the universe of human proteins at neXtProt for MED6: NX_O75586

Explore proteomics data for MED6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75586

  • MED6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MED6 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001271138.1  NP_001271139.1  NP_001271140.1  NP_005457.2  

    ENSEMBL proteins: 
     ENSP00000451684   ENSP00000256379   ENSP00000413343   ENSP00000394502  
    Reactome Protein details: O75586
    Human Recombinant Protein Products for MED6: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MED6
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MED6
    GenScript Custom Purified and Recombinant Proteins Services for MED6
    Novus Biologicals MED6 Protein
    Novus Biologicals MED6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MED6 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10024883
    GO:0005654nucleoplasm TAS--
    GO:0016592mediator complex IMP17641689

    MED6 for ontologies           About GeneDecksing



    MED6 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Custom Antibody Services for MED6
    GenScript Custom Superior Antibodies Services for MED6
    Novus Biologicals MED6 Antibodies
    Abcam antibodies for MED6
    Cloud-Clone Corp. Antibodies for MED6 
    Search ThermoFisher Antibodies for MED6
    LSBio Antibodies in human, mouse, rat for MED6 

    Assay Products for MED6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED6 
    Cloud-Clone Corp. CLIAs for MED6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR016820 Mediator_Med6_met/pln
     IPR007018 Mediator_Med6

    Graphical View of Domain Structure for InterPro Entry O75586

    ProtoNet protein and cluster: O75586

    UniProtKB/Swiss-Prot: MED6_HUMAN, O75586
    Similarity: Belongs to the Mediator complex subunit 6 family


    MED6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED6_HUMAN, O75586
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IEA--
    GO:0003677DNA binding IEA--
    GO:0003713transcription coactivator activity IDA12037571
    GO:0005515protein binding ----
    GO:0008134transcription factor binding IPI17641689
         
    MED6 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for MED6:
     Decreased G3BP1 protein expres  Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 
     Decreased p24 protein expressi  Decreased viability with pacli  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MED6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MED6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MED6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MED6 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MED6:
    hsa-mir-199a-5p (MIRT004393), hsa-mir-199b-3p (MIRT004394)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED6
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate MED6 (see all 17):
    hsa-miR-300 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3125 hsa-miR-3916 hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidMED6 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MED6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED6
    Sirion Biotech Customized adenovirus for overexpression of MED6

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MED6 (see all 9)
    OriGene ORF clones in mouse, rat for MED6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED6 (NM_005466)
    Sino Biological Human cDNA Clone for MED6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED6
    Sirion Biotech Customized lentivirus for stable overexpression of MED6 
                         Customized lentivirus expression plasmids for stable overexpression of MED6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MED6
    Search LifeMap BioReagents cell lines for MED6
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MED6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    2Axon guidance
    Developmental Biology0.69
    3Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes1.00
    4Transcriptional Regulation of White Adipocyte Differentiation
    Transcriptional Regulation of White Adipocyte Differentiation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MED6
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    1 GeneGo (Thomson Reuters) Pathway for MED6
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    4        Reactome Pathways for MED6
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation
    Generic Transcription Pathway
    Gene Expression



    MED6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MED6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/124 Interacting proteins for MED6 (O755862, 3 ENSP000002563794) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157962, 3, ENSP000002621604MINT-15456 I2D: score=4 STRING: ENSP00000262160
    ENSG00000227333Q96KQ73, ENSP000003973234I2D: score=1 STRING: ENSP00000397323
    EHMT2Q96KQ73I2D: score=1 
    ENSG00000206376Q96KQ73I2D: score=1 
    ENSG00000232045Q96KQ73I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS10024883
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0019827stem cell maintenance IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA12037571

    MED6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MED6

    Search CenterWatch for drugs/clinical trials and news about MED6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MED6 gene (4 alternative transcripts): 
    NM_001284209.1  NM_001284210.1  NM_001284211.1  NM_005466.3  

    Unigene Cluster for MED6:

    Mediator complex subunit 6
    Hs.497353  [show with all ESTs]
    Unigene Representative Sequence: AK222587
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000554963 ENST00000256379(uc001xmf.3 uc010tti.2) ENST00000430055(uc010tth.2)
    ENST00000440435 ENST00000555296 ENST00000553611 ENST00000556044 ENST00000556495(uc001xmg.1)
    ENST00000554870(uc010ttj.2) ENST00000553523 ENST00000556423
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED6
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate MED6 (see all 17):
    hsa-miR-300 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3125 hsa-miR-3916 hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidMED6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MED6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED6
    Clone
    Products:
         
    OriGene clones in human, mouse for MED6 (see all 9)
    OriGene ORF clones in mouse, rat for MED6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED6 (NM_005466)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED6
    Sirion Biotech Customized lentivirus for stable overexpression of MED6 
                         Customized lentivirus expression plasmids for stable overexpression of MED6 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MED6
    OriGene qSTAR qPCR primer pairs in human, mouse for MED6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED6

    Additional mRNA sequence: 

    AF074723.1 AF155104.1 AK222587.1 AK223346.1 AK290647.1 AK300417.1 AK300460.1 AK304361.1 
    BC004106.2 BT006831.1 CR541697.1 U78082.1 

    9 DOTS entries:

    DT.407540  DT.75142928  DT.92423899  DT.120792786  DT.100765107  DT.100023796  DT.100762064  DT.75101240 
    DT.91953847 

    24/104 AceView cDNA sequences (see all 104):

    AI621182 BM832492 BP379959 AA613346 BP369326 BE909461 R99951 BU957680 
    BQ641743 CB138000 AA305926 CR608591 BP350015 BQ433395 BM800780 AA135936 
    BM981244 BC004106 BM999935 BU192589 BM791166 NM_005466 BM552230 BM808773 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MED6 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7
    SP1:        -                       -     -           -     -           -               
    SP2:                                -     -           -                 -               
    SP3:        -                       -     -           -     -                           
    SP4:        -                       -     -                                             
    SP5:        -                                                                           


    ECgene alternative splicing isoforms for MED6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MED6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTACTGGTA
    MED6 Expression
    About this image


    See MED6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MED6

    SOURCE GeneReport for Unigene cluster: Hs.497353
        SABiosciences Custom PCR Arrays for MED6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MED6
    OriGene qSTAR qPCR primer pairs in human, mouse for MED6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MED6 gene from 10/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med61 , 5 mediator of RNA polymerase II transcription, subunit more1, 5 91.45(n)1
    93.85(a)1
      12 (37.80 cM)5
    697921  NM_027213.21  NP_081489.21 
     815735575 
    chicken
    (Gallus gallus)
    Aves MED61 mediator complex subunit 6 80.49(n)
    88.62(a)
      426282  NM_001159425.1  NP_001152897.1 
    lizard
    (Anolis carolinensis)
    Reptilia MED66
    mediator complex subunit 6
    87(a)
    1 ↔ 1
    GL343753.1(84100-119256)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.18072 Transcribed sequence with strong similarity to protein more 79.91(n)    137732606 
    zebrafish
    (Danio rerio)
    Actinopterygii med61 mediator complex subunit 6 68.84(n)
    78.78(a)
      415174  NM_001002084.1  NP_001002084.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Med63
    MED61
    transcription from Pol II promoter RNA
    polymerase more3
    Mediator complex subunit 61
    54(a)3
    51.19(n)1
    47.7(a)1
      85E83
    447281  NM_169310.21  NP_731403.21 
    worm
    (Caenorhabditis elegans)
    Secernentea mdt-61 Protein MDT-6 49.46(n)
    40(a)
      179091  NM_072390.3  NP_504791.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MED6(YHR058C)4 Subunit of the RNA polymerase II mediator complex; more   --   8(219884-218997) 856455  NP_011925.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MED61 RNA polymerase transcriptional regulation mediator-like more 46.06(n)
    38.18(a)
      821689  NM_113030.4  NP_188772.2 
    rice
    (Oryza sativa)
    Liliopsida Os06g02175001 hypothetical protein 46.04(n)
    39.11(a)
      4340496  NM_001063685.1  NP_001057150.1 


    ENSEMBL Gene Tree for MED6 (if available)
    TreeFam Gene Tree for MED6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MED6 gene

    MED6 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MED6
    PGOHUM00000238574 PGOHUM00000237733


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/434 SNPs in MED6 are shown (see all 434)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894061251,2
    --71050476(+) AGATAC/TAATAA 1 -- ds50010--------
    rs1494902651,2
    --71050480(+) ATAATA/GAAGTA 1 -- ds50010--------
    rs1814482741,2
    --71050495(+) TGTACA/GAAAGG 1 -- ds50010--------
    rs1169662871,2
    F--71050509(+) GATTAA/CAGTAC 1 -- ds50011Minor allele frequency- C:0.01NA 120
    rs727197621,2
    C,F--71050546(+) AGCACA/GCTCAG 1 -- ds50011Minor allele frequency- G:0.04NA 120
    rs783482291,2
    --71050561(+) CTTGCC/GATGAG 1 -- ds50010--------
    rs766159241,2
    C,F--71050588(+) AGGGAC/TTTTGC 1 -- ds50011Minor allele frequency- T:0.08EA 120
    rs1388397441,2
    --71050613(+) CAAGAA/TGGCCC 1 -- ds50010--------
    rs592339241,2
    C--71050660(+) CCTCCA/GTAACT 1 -- ds50014Minor allele frequency- G:0.26WA NA EA 360
    rs118447311,2
    C,F,H--71050715(+) CTACAC/TACAGA 1 -- ds5001 ese37Minor allele frequency- T:0.11NS EA WA 658

    HapMap Linkage Disequilibrium report for MED6 (71047974 - 71067384 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MED6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv517712CNV Loss19592680
    nsv819471CNV Gain19587683

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602984    OMIM disorders: --

    4 diseases for MED6:    About MalaCards
    spondylolysis    renal cell carcinoma    mental retardation    neuronitis


    MED6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MED6
    Human Genome Epidemiology (HuGE) Navigator: MED6 (1 document)

    Export disorders for MED6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MED6 gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with MED6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S....Conaway R.C. (2004)
    4. The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. (PubMed id 11867769)1, 2 Kang Y.K.... Roeder R.G. (2002)
    5. TFIIH is negatively regulated by cdk8-containing mediator complexes. (PubMed id 10993082)1, 2 Akoulitchev S.... Reinberg D. (2000)
    6. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. (PubMed id 10024883)1, 2 Gu W.... Roeder R.G. (1999)
    7. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (1999)
    8. Composite co-activator ARC mediates chromatin-directed transcriptional activation. (PubMed id 10235267)1, 2 Naeaer A.M....Tjian R. (1999)
    9. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. (PubMed id 9671713)1, 3 Jiang Y.W.... Kornberg R.D. (1998)
    10. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. (PubMed id 9734358)1, 2 Sun X.... Reinberg D. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10001 HGNC: 19970 AceView: MED6 Ensembl:ENSG00000133997 euGenes: HUgn10001
    ECgene: MED6 H-InvDB: MED6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MED6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MED6 gene:
    Search GeneIP for patents involving MED6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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