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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MED4 Gene

protein-coding   GIFtS: 59
GCID: GC13M048627

mediator complex subunit 4

(Previous names: vitamin D receptor interacting protein, mediator of RNA...)
(Previous symbol: VDRIP)
 Explore 4 diseases affiliated with
MED4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MED4    

Aliases
for MED4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mediator Complex Subunit 41 2 3     Mediator Of RNA Polymerase II Transcription, Subunit 4 Homolog (S. Cerevisiae)1
DRIP361 2 3 5     Vitamin D Receptor Interacting Protein1
VDRIP1 2 3     Mediator Of RNA Polymerase II Transcription Subunit 42
HSPC1261 2 5     Mediator, 34-KD Subunit, Homolog2
TRAP361 2     TRAP/SMCC/PC2 Subunit P362
Activator-Recruited Cofactor 36 KDa Component2 3     Vitamin D Receptor-Interacting Protein, 36-KD2
Vitamin D3 Receptor-Interacting Protein Complex 36 KDa Component2 3     TRAP/SMCC/PC2 Subunit P36 Subunit3
ARC362 3     

External Ids:    HGNC: 179031   Entrez Gene: 290792   Ensembl: ENSG000001361467   OMIM: 6057185   UniProtKB: Q9NPJ63   
ORGUL members:         
NONCODE:n338711    

Export aliases for MED4 gene to outside databases

Previous GC identifers: GC13M047550 GC13M029442


Summaries
for MED4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MED4:
This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific
transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants
encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: MED4_HUMAN, Q9NPJ6
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED4


Genomic Views
for MED4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MED4 gene promoter:
         c-Fos   STAT5B   AP-1   p300   POU3F1   Nkx2-5   SRY   PPAR-gamma1   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MED4 promoter sequence
   Search SABiosciences Chromatin IP Primers for MED4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.2   Ensembl cytogenetic band:  13q14.2   HGNC cytogenetic band: 13q14.12

MED4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED4 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M048627:  view genomic region     (about GC identifiers)

Start:
 48,627,459 bp from pter      End:
 48,669,267 bp from pter
Size:
 41,809 bases      Orientation:
 minus strand

Proteins
for MED4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MED4_HUMAN, Q9NPJ6 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 4  
Size: 270 amino acids; 29745 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in
supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct
subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Subcellular location: Nucleus
Secondary accessions: Q53GB4 Q53H68 Q5T912 Q6FHC4 Q6IA79 Q9BS95 Q9NYR5

Explore the universe of human proteins at neXtProt for MED4: NX_Q9NPJ6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NPJ6

    • MED4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001257558.1  NP_054885.1  

    ENSEMBL proteins: 
     ENSP00000258648   ENSP00000367849   ENSP00000413595  
    Reactome Protein details: Q9NPJ6
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MED4
    OriGene Protein Over-expression Lysate: MED4
    OriGene Custom Protein Services for MED4 
    GenScript Custom Purified and Recombinant Proteins Services for MED4
    Novus Biologicals MED4 Proteins
    Novus Biologicals MED4 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for MED4
    Uscn Proteins for MED4

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0016592mediator complex IDA14638676


    MED4 for ontologies           About GeneDecksing



    MED4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for MED4
    OriGene Antibodies (see all 2): MED4
    OriGene Custom Antibody Services for MED4 
    GenScript Custom Superior Antibodies Services for MED4
    Novus Biologicals MED4 Antibodies
    Abcam antibodies for MED4 
    Uscn Antibodies for MED4
    ThermoFisher Antibody for MED4

    Assay Products for MED4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED4
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MED4

    Protein Domains /
    Families
    for MED4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MED4 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019258 Mediator_Med4

    Graphical View of Domain Structure for InterPro Entry Q9NPJ6

    ProtoNet protein and cluster: Q9NPJ6

    UniProtKB/Swiss-Prot: MED4_HUMAN, Q9NPJ6
    Similarity: Belongs to the Mediator complex subunit 4 family


    Function
    for MED4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MED4_HUMAN, Q9NPJ6
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
    polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
    proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
    interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
    with RNA polymerase II and the general transcription factors

    miRNA
    Products:            		 OriGene 3'-UTR Clone: MED4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED4
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate MED4 (see all 12):
    hsa-miR-3163 hsa-miR-576-5p hsa-miR-520d-5p hsa-miR-548e hsa-miR-4263 hsa-miR-190b hsa-miR-1305 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmid: MED4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED4 (see all 7)
    OriGene shRNA RFP: MED4
    OriGene siRNA: MED4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MED4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED4 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MED4 (NM_014166)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MED4
    Search LifeMap BioReagents cell lines for MED4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED4

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IDA10882111
    GO:0003712transcription cofactor activity IDA12218053
    GO:0004872receptor activity IDA12218053
    GO:0005515protein binding IPI15175163
    GO:0030374ligand-dependent nuclear receptor transcription coactivator activity NAS10235266


    MED4 for ontologies           About GeneDecksing


    7 GenomeRNAi human phenotypes for MED4:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella enterica   Decreased Salmonella-containin  Decreased p24 protein expressi 


    Pathways & Interactions
    for MED4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    		Generic Transcription Pathway1.00
    		Gene Expression0.46
    2HIV Infection
    		Transcription Ligand-Dependent Transcription of Retinoid-Target genes0.28
    		Transcription_Ligand-Dependent Transcription of Retinoid-Target genes0.28
    3Transcriptional Regulation of White Adipocyte Differentiation
    		Transcriptional Regulation of White Adipocyte Differentiation1.00
    4Axon guidance
    		Developmental Biology0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for MED4
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    1 GeneGo (Thomson Reuters) Pathway for MED4
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    4        Reactome Pathways for MED4
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation
    Generic Transcription Pathway
    Gene Expression



    MED4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MED4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/846 Interacting proteins for MED4 (Q9NPJ61, 2, 3 ENSP000002586484) via UniProtKB, MINT, STRING, and/or I2D (see all 846)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFAIP8O953792, 3, ENSP000004085344MINT-66580 I2D: score=5 STRING: ENSP00000408534
    EXOC2Q96KP12, 3MINT-7945693 MINT-7947479 I2D: score=4 
    MED9Q9NWA01, 3, ENSP000002687114EBI-394607,EBI-394653 I2D: score=3 STRING: ENSP00000268711
    PRPF3O433952, 3MINT-7947479 I2D: score=4 
    ATF7IPQ6VMQ62, 3MINT-61901 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter IDA10882111
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0030518intracellular steroid hormone receptor signaling pathway IDA11867769
    GO:0030521androgen receptor signaling pathway IDA12218053


    MED4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MED4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MED4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MED4
    2 Novoseek chemical compound relationships for MED4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin d 68.1 7 17229570 (1), 10753860 (1), 15886699 (1), 12403843 (1) (see all 6)
    steroid 37.8 3 17229570 (1), 12403843 (1), 15577143 (1)

    Search CenterWatch for drugs/clinical trials and news about MED4 

    Transcripts
    for MED4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MED4 gene (2 alternative transcripts): 
    NM_001270629.1  NM_014166.3  

    Unigene Cluster for MED4:

    Mediator complex subunit 4
    Hs.181112  [show with all ESTs]
    Unigene Representative Sequence: NM_014166
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495013 ENST00000258648(uc001vby.1 uc010tgf.1) ENST00000378586
    ENST00000487937 ENST00000417167

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MED4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED4
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate MED4 (see all 12):
    hsa-miR-3163 hsa-miR-576-5p hsa-miR-520d-5p hsa-miR-548e hsa-miR-4263 hsa-miR-190b hsa-miR-1305 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmid: MED4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED4 (see all 7)
    OriGene shRNA RFP: MED4
    OriGene siRNA: MED4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED4
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED4 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MED4 (NM_014166)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED4

    Additional cDNA sequence: 

    AF161475.1 AF230381.1 AF300618.1 AK001934.1 AK222713.1 AK223017.1 AK301835.1 BC005189.1 
    CR457276.1 CR541830.1 

    11 DOTS entries:

    DT.454773  DT.100811867  DT.100822742  DT.100822741  DT.91680123  DT.92025551  DT.95362377  DT.99932104 
    DT.92450372  DT.97781406  DT.86839601 

    24/362 AceView cDNA sequences (see all 362):

    CA412587 BF940046 BI064312 CB136171 CR590107 BU607683 CR617886 AK001934 
    AW629268 CB215344 AI129554 BQ574601 AA454015 AI493209 AA694200 AW051867 
    BM762102 AA401381 CR598896 BQ574748 CB243881 AI049615 BM661614 BQ014752 

    GeneLoc Exon Structure


    Expression
    for MED4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MED4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAAATTGTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MED4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MED4

    SOURCE GeneReport for Unigene cluster: Hs.181112
        SABiosciences Expression via Pathway-Focused PCR Arrays including MED4: 
              Nitric Oxide Signaling Pathway in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED4

    Orthologs
    for MED4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MED4 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Med41 , 5 mediator of RNA polymerase II transcription, subunit more1, 5 86.91(n)1
    94.44(a)1    		   14 (39.05 cM)5
    673811  NM_026119.31  NP_080395.11 
     735100495 
    chicken
    (Gallus gallus)    		 Aves MED41 mediator complex subunit 4 80.8(n)
    89.11(a)    		   418859  XM_417054.3  XP_417054.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MED46
    		 --
    		 83(a)
    		 1 ↔ 1
    		 1(136984436-136997431)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.87382 Xenopus laevis transcribed sequence with moderate similarity more 76.22(n)    CF520285.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.180602 Transcribed sequence with moderate similarity to protein more 70.84(n)    CK353711.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta MED41 Mediator complex subunit 4 53.68(n)
    48.05(a)    		   38799  NM_139837.2  NP_648094.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea mdt-46
    		 Mediator of RNA polymerase II transcription subuni...
    		 25(a)
    		 1 ↔ 1
    		 II(4942101-4943936)


    ENSEMBL Gene Tree for MED4 (if available)
    TreeFam Gene Tree for MED4 (if available) 

    Paralogs
    for MED4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for MED4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/421 NCBI SNPs in MED4 are shown (see all 421)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1408590261,2
    		--48649481(+) TCCTTC/TAAATA 3 -- us2k1 ds50010--------
    rs1501959691,2
    		--48649570(+) AGGGCA/GGCCTC 3 -- ds5001 us2k10--------
    rs1386894321,2
    		--48649662(+) GGTGAC/GACCCA 3 -- ds5001 us2k10--------
    rs1416697551,2
    		--48649708(+) TGTGTC/TGTTTT 3 -- us2k1 ds50010--------
    rs1882413611,2
    		--48649847(+) GCACAC/TACCAC 3 -- us2k1 ds50010--------
    rs1383855671,2
    		--48649921(+) GTATAC/TGGACA 3 -- ut31 us2k10--------
    rs73375211,2
    		C,F,A,H,--48650001(+) ACATTG/TTATGT 3 -- us2k1 ut3121Minor allele frequency- T:0.08NS EA NA CSA WA 2627
    rs173503421,2
    		C,F,H,--48650078(+) ATAATC/AAAAAG 3 -- ut31 us2k18Minor allele frequency- A:0.01NA NS EA 654
    rs1440415271,2
    		--48650100(+) GGAAAA/CATGGA 3 -- us2k1 ut310--------
    rs10646311,2
    		C--48650247(-) ACCCAG/AAGATA 3 -- ut31 us2k1 ese32Minor allele frequency- A:0.00NA 4

    HapMap Linkage Disequilibrium report for MED4 (48627459 - 48669267 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MED4
         1 CNV: 4803

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MED4
    DNA2.0 Custom Variant and Variant Library Synthesis for MED4

    Disorders / Diseases
    for MED4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MED4 for disorders           About GeneDecksing

    OMIM gene information: 605718    OMIM disorders: --

    4 diseases for MED4:    About MalaCards
    hereditary hypophosphatemic rickets    rickets    alopecia    thyroiditis

    Human Genome Epidemiology (HuGE) Navigator: MED4 (1 document)

    Export disorders for MED4 gene to outside databases

    Publications
    for MED4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MED4 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with MED4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
    2. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. (PubMed id 10235266)1, 2, 3 Rachez C.... Freedman L.P. (1999)
    3. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
    4. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S....Conaway R.C. (2004)
    8. The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs. (PubMed id 10882111)1, 2 Malik S.... Roeder R.G. (2000)
    9. Composite co-activator ARC mediates chromatin-directed transcriptional activation. (PubMed id 10235267)1, 2 Naeaer A.M....Tjian R. (1999)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    External Searches for MED4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MED4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29079 HGNC: 17903 AceView: VDRIP Ensembl:ENSG00000136146 euGenes: HUgn29079
    ECgene: MED4 H-InvDB: MED4

    Other Databases showing MED4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MED4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MED4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MED4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MED4 gene:
    Search GeneIP for patents involving MED4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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     Regulatory tfbs in MED4 promoter
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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