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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MED4 Gene

protein-coding   GIFtS: 60
GCID: GC13M048627

Mediator Complex Subunit 4

(Previous names: vitamin D receptor interacting protein, mediator of RNA...)
(Previous symbol: VDRIP)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mediator Complex Subunit 41 2 3     Vitamin D Receptor Interacting Protein1
VDRIP1 2 3     TRAP362
DRIP362 3 5     Mediator Of RNA Polymerase II Transcription Subunit 42
Activator-Recruited Cofactor 36 KDa Component2 3     Mediator, 34-KD Subunit, Homolog2
Vitamin D3 Receptor-Interacting Protein Complex 36 KDa Component2 3     TRAP/SMCC/PC2 Subunit P362
ARC362 3     Vitamin D Receptor-Interacting Protein, 36-KD2
HSPC1262 5     TRAP/SMCC/PC2 Subunit P36 Subunit3
Mediator Of RNA Polymerase II Transcription, Subunit 4 Homolog (S.
Cerevisiae)1
     

External Ids:    HGNC: 179031   Entrez Gene: 290792   Ensembl: ENSG000001361467   OMIM: 6057185   UniProtKB: Q9NPJ63   
ORGUL members:         
NONCODE14:n338711      

Export aliases for MED4 gene to outside databases

Previous GC identifers: GC13M047550 GC13M029442


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MED4 Gene:
This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding
gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced
transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Jul 2012)

GeneCards Summary for MED4 Gene: 
MED4 (mediator complex subunit 4) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with MED4 include hereditary hypophosphatemic rickets, and rickets, and among its related super-pathways are Gene Expression and Axon guidance. GO annotations related to this gene include receptor activity and ligand-dependent nuclear receptor transcription coactivator activity.

UniProtKB/Swiss-Prot: MED4_HUMAN, Q9NPJ6
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MED4 gene promoter:
         c-Fos   STAT5B   AP-1   p300   POU3F1   Nkx2-5   SRY   PPAR-gamma1   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED4 promoter sequence
   Search SABiosciences Chromatin IP Primers for MED4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.2   Ensembl cytogenetic band:  13q14.2   HGNC cytogenetic band: 13q14.12

MED4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED4 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M048627:  view genomic region     (about GC identifiers)

Start:
48,627,459 bp from pter      End:
48,669,267 bp from pter
Size:
41,809 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MED4_HUMAN, Q9NPJ6 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 4  
Size: 270 amino acids; 29745 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Subcellular location: Nucleus
Secondary accessions: B4DX67 Q53GB4 Q53H68 Q5T912 Q6FHC4 Q6IA79 Q9BS95 Q9NYR5
Alternative splicing: 2 isoforms:  Q9NPJ6-1   Q9NPJ6-2   

Explore the universe of human proteins at neXtProt for MED4: NX_Q9NPJ6

Explore proteomics data for MED4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NPJ6

  • MED4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MED4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001257558.1  NP_054885.1  

    ENSEMBL proteins: 
     ENSP00000258648   ENSP00000367849   ENSP00000413595  
    Reactome Protein details: Q9NPJ6
    Human Recombinant Protein Products for MED4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MED4
    OriGene Protein Over-expression Lysate for MED4
    OriGene MassSpec for MED4 
    OriGene Custom Protein Services for MED4
    GenScript Custom Purified and Recombinant Proteins Services for MED4
    Novus Biologicals MED4 Proteins
    Novus Biologicals MED4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for MED4
    Cloud-Clone Corp. Proteins for MED4 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0016592mediator complex IDA10882111

    MED4 for ontologies           About GeneDecksing



    MED4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for MED4
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    Novus Biologicals MED4 Antibodies
    Abcam antibodies for MED4
    Cloud-Clone Corp. Antibodies for MED4 
    ThermoFisher Antibody for MED4
    LSBio Antibodies in human, mouse, rat for MED4 

    Assay Products for MED4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED4 
    Cloud-Clone Corp. CLIAs for MED4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019258 Mediator_Med4

    Graphical View of Domain Structure for InterPro Entry Q9NPJ6

    ProtoNet protein and cluster: Q9NPJ6

    UniProtKB/Swiss-Prot: MED4_HUMAN, Q9NPJ6
    Similarity: Belongs to the Mediator complex subunit 4 family


    MED4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED4_HUMAN, Q9NPJ6
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IDA10882111
    GO:0003712transcription cofactor activity IDA12218053
    GO:0004872receptor activity IDA12218053
    GO:0005515protein binding IPI14638676
    GO:0030374ligand-dependent nuclear receptor transcription coactivator activity NAS10235266
         
    MED4 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for MED4:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella enterica   Decreased Salmonella-containin  Decreased p24 protein expressi 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MED4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MED4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MED4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MED4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED4
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate MED4 (see all 12):
    hsa-miR-3163 hsa-miR-576-5p hsa-miR-520d-5p hsa-miR-548e hsa-miR-4263 hsa-miR-190b hsa-miR-1305 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidMED4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MED4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED4
    Sirion Biotech Customized adenovirus for overexpression of MED4

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MED4 (see all 8)
    OriGene ORF clones in mouse, rat for MED4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED4 (NM_014166)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED4
    Sirion Biotech Customized lentivirus for stable overexpression of MED4 
                         Customized lentivirus expression plasmids for stable overexpression of MED4 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MED4
    Search LifeMap BioReagents cell lines for MED4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MED4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    2Axon guidance
    Developmental Biology0.69
    3Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes1.00
    4Transcriptional Regulation of White Adipocyte Differentiation
    Transcriptional Regulation of White Adipocyte Differentiation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MED4
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    1 GeneGo (Thomson Reuters) Pathway for MED4
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    4        Reactome Pathways for MED4
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation
    Generic Transcription Pathway
    Gene Expression



    MED4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MED4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/883 Interacting proteins for MED4 (Q9NPJ61, 2, 3 ENSP000002586484) via UniProtKB, MINT, STRING, and/or I2D (see all 883)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFAIP8O953792, 3, ENSP000004085344MINT-66580 I2D: score=5 STRING: ENSP00000408534
    EXOC2Q96KP12, 3MINT-7945693 MINT-7947479 I2D: score=4 
    MED9Q9NWA01, 3, ENSP000002687114EBI-394607,EBI-394653 I2D: score=3 STRING: ENSP00000268711
    PRPF3O433952, 3MINT-7947479 I2D: score=4 
    ATF7IPQ6VMQ62, 3MINT-61901 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006366transcription from RNA polymerase II promoter IDA10882111
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0030518intracellular steroid hormone receptor signaling pathway IDA11867769

    MED4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MED4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MED4

    2 Novoseek inferred chemical compound relationships for MED4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin d 68.1 7 17229570 (1), 10753860 (1), 15886699 (1), 12403843 (1) (see all 6)
    steroid 37.8 3 17229570 (1), 12403843 (1), 15577143 (1)

    Search CenterWatch for drugs/clinical trials and news about MED4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MED4 gene (2 alternative transcripts): 
    NM_001270629.1  NM_014166.3  

    Unigene Cluster for MED4:

    Mediator complex subunit 4
    Hs.181112  [show with all ESTs]
    Unigene Representative Sequence: NM_014166
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495013 ENST00000258648(uc001vby.1 uc010tgf.1) ENST00000378586
    ENST00000417167
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED4
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate MED4 (see all 12):
    hsa-miR-3163 hsa-miR-576-5p hsa-miR-520d-5p hsa-miR-548e hsa-miR-4263 hsa-miR-190b hsa-miR-1305 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidMED4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MED4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED4
    Clone
    Products:
         
    OriGene clones in human, mouse for MED4 (see all 8)
    OriGene ORF clones in mouse, rat for MED4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED4 (NM_014166)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED4
    Sirion Biotech Customized lentivirus for stable overexpression of MED4 
                         Customized lentivirus expression plasmids for stable overexpression of MED4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MED4
    OriGene qSTAR qPCR primer pairs in human, mouse for MED4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED4

    Additional mRNA sequence: 

    AF161475.1 AF230381.1 AF300618.1 AK001934.1 AK222713.1 AK223017.1 AK301835.1 BC005189.1 
    CR457276.1 CR541830.1 

    11 DOTS entries:

    DT.454773  DT.100811867  DT.100822742  DT.100822741  DT.91680123  DT.92025551  DT.95362377  DT.99932104 
    DT.92450372  DT.97781406  DT.86839601 

    24/362 AceView cDNA sequences (see all 362):

    CR590107 CB243881 AI129554 AA918389 BQ574748 AI909679 BF445860 BU621831 
    AI346471 AI049615 AW068882 Z38805 BG499588 CB122164 AI203779 AI910720 
    CD514515 AA706926 BM461559 CR617886 AF300618 CB215344 BQ014752 BU677187 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MED4 expression in normal human tissues (normalized intensities)      MED4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAATTGTC
    MED4 Expression
    About this image


    MED4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             bone marrow cd34+   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See MED4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MED4

    SOURCE GeneReport for Unigene cluster: Hs.181112
        SABiosciences Expression via Pathway-Focused PCR Arrays including MED4: 
              Nitric Oxide Signaling Pathway in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MED4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MED4 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med41 , 5 mediator of RNA polymerase II transcription, subunit more1, 5 86.91(n)1
    94.44(a)1
      14 (39.05 cM)5
    673811  NM_026119.31  NP_080395.11 
     735100495 
    chicken
    (Gallus gallus)
    Aves MED41 mediator complex subunit 4 80.8(n)
    89.11(a)
      418859  XM_417054.3  XP_417054.1 
    lizard
    (Anolis carolinensis)
    Reptilia MED46
    Uncharacterized protein
    87(a)
    1 ↔ 1
    1(136981731-136997875)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.87382 Xenopus laevis transcribed sequence with moderate similarity more 76.22(n)    CF520285.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.180602 Transcribed sequence with moderate similarity to protein more 70.84(n)    CK353711.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED41 Mediator complex subunit 4 53.68(n)
    48.05(a)
      38799  NM_139837.2  NP_648094.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mdt-46
    Mediator of RNA polymerase II transcription subuni...
    26(a)
    1 ↔ 1
    II(4942107-4943942)


    ENSEMBL Gene Tree for MED4 (if available)
    TreeFam Gene Tree for MED4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/380 SNPs in MED4 are shown (see all 380)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1438357861,2
    --48654670(+) TTCTAC/TACTTT 2 -- int10--------
    rs1384755921,2
    --48654749(+) AATTAC/TTCAAA 2 -- int10--------
    rs1881049261,2
    --48654796(+) TATGCC/TGCAAG 2 -- int10--------
    rs95679921,2
    C,F,H--48654837(+) GAAAGG/AACTGG 2 -- int18Minor allele frequency- A:0.09NS EA CSA WA NA 660
    rs112993251,2
    C--48654878(+) AAATC-/TTTTTT 2 -- int1 trp31Minor allele frequency- T:0.00NA 2
    rs1415832861,2
    --48654951(+) TAAAAC/TCTTTT 2 -- int10--------
    rs1461699481,2
    --48654997(+) TAATTC/TGTGTA 2 -- int10--------
    rs1928692271,2
    --48655022(+) AGGAGA/CAGGTA 2 -- int10--------
    rs1846331041,2
    --48655063(+) ATAGCA/GGTATG 2 -- int10--------
    rs73238211,2
    C,F,H--48655130(+) TGCAGA/CTTATC 2 -- int117Minor allele frequency- C:0.04NS EA NA WA CSA 789

    HapMap Linkage Disequilibrium report for MED4 (48627459 - 48669267 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MED4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676750CNV Deletion23128226
    nsv832601CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605718    OMIM disorders: --

    7 diseases for MED4:    About MalaCards
    hereditary hypophosphatemic rickets    rickets    alopecia    type 1 diabetes
    cervicitis    retinitis    thyroiditis


    MED4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MED4
    Human Genome Epidemiology (HuGE) Navigator: MED4 (1 document)

    Export disorders for MED4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MED4 gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with MED4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
    2. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. (PubMed id 10235266)1, 2, 3 Rachez C.... Freedman L.P. (1999)
    3. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
    4. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S....Conaway R.C. (2004)
    8. The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs. (PubMed id 10882111)1, 2 Malik S.... Roeder R.G. (2000)
    9. Composite co-activator ARC mediates chromatin-directed transcriptional activation. (PubMed id 10235267)1, 2 Naeaer A.M....Tjian R. (1999)
    10. Identification of the hypoxia-inducible factor 2a nucl ear interactome in melanoma cells reveals master proteins involved in melanoma d evelopment. (PubMed id 23275444)1 Steunou A.L....Nieto L. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29079 HGNC: 17903 AceView: VDRIP Ensembl:ENSG00000136146 euGenes: HUgn29079
    ECgene: MED4 H-InvDB: MED4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MED4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MED4 gene:
    Search GeneIP for patents involving MED4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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