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Aliases for MED4 Gene

Aliases for MED4 Gene

  • Mediator Complex Subunit 4 2 3 4
  • Vitamin D3 Receptor-Interacting Protein Complex 36 KDa Component 3 4
  • Activator-Recruited Cofactor 36 KDa Component 3 4
  • DRIP36 3 4
  • VDRIP 3 4
  • ARC36 3 4
  • Mediator Of RNA Polymerase II Transcription, Subunit 4 Homolog (S. Cerevisiae) 2
  • Vitamin D Receptor-Interacting Protein, 36-KD 3
  • Vitamin D Receptor Interacting Protein 2
  • TRAP/SMCC/PC2 Subunit P36 Subunit 4
  • Mediator, 34-KD Subunit, Homolog 3
  • TRAP/SMCC/PC2 Subunit P36 3
  • HSPC126 3
  • TRAP36 3

External Ids for MED4 Gene

Previous HGNC Symbols for MED4 Gene

  • VDRIP

Previous GeneCards Identifiers for MED4 Gene

  • GC13M047550
  • GC13M048627
  • GC13M029442

Summaries for MED4 Gene

Entrez Gene Summary for MED4 Gene

  • This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for MED4 Gene

MED4 (Mediator Complex Subunit 4) is a Protein Coding gene. Among its related pathways are Developmental Biology and Metabolism. GO annotations related to this gene include receptor activity and ligand-dependent nuclear receptor transcription coactivator activity.

UniProtKB/Swiss-Prot for MED4 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED4 Gene

Genomics for MED4 Gene

Regulatory Elements for MED4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MED4 Gene

Chromosome:
13
Start:
48,053,323 bp from pter
End:
48,095,141 bp from pter
Size:
41,819 bases
Orientation:
Minus strand

Genomic View for MED4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MED4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED4 Gene

Proteins for MED4 Gene

  • Protein details for MED4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPJ6-MED4_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 4
    Protein Accession:
    Q9NPJ6
    Secondary Accessions:
    • B4DX67
    • Q53GB4
    • Q53H68
    • Q5T912
    • Q6FHC4
    • Q6IA79
    • Q9BS95
    • Q9NYR5

    Protein attributes for MED4 Gene

    Size:
    270 amino acids
    Molecular mass:
    29745 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

    Alternative splice isoforms for MED4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED4 Gene

Proteomics data for MED4 Gene at MOPED

Post-translational modifications for MED4 Gene

  • Ubiquitination at Lys 55, Lys 81, Lys 98, Lys 112, and Lys 150
  • Modification sites at PhosphoSitePlus

Other Protein References for MED4 Gene

Antibody Products

No data available for DME Specific Peptides for MED4 Gene

Domains & Families for MED4 Gene

Gene Families for MED4 Gene

Protein Domains for MED4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NPJ6

UniProtKB/Swiss-Prot:

MED4_HUMAN :
  • Belongs to the Mediator complex subunit 4 family.
Family:
  • Belongs to the Mediator complex subunit 4 family.
genes like me logo Genes that share domains with MED4: view

Function for MED4 Gene

Molecular function for MED4 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

Gene Ontology (GO) - Molecular Function for MED4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IDA 10882111
GO:0003712 transcription cofactor activity IDA 12218053
GO:0004872 receptor activity IDA 12218053
GO:0005515 protein binding IPI 14638676
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity NAS 10235266
genes like me logo Genes that share ontologies with MED4: view
genes like me logo Genes that share phenotypes with MED4: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MED4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MED4 Gene

Localization for MED4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED4 Gene COMPARTMENTS Subcellular localization image for MED4 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for MED4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10235267
GO:0005654 nucleoplasm TAS --
GO:0016020 membrane IDA 19946888
GO:0016592 mediator complex IDA 10882111
GO:0070847 core mediator complex IBA --
genes like me logo Genes that share ontologies with MED4: view

Pathways & Interactions for MED4 Gene

genes like me logo Genes that share pathways with MED4: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MED4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IDA 10882111
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
GO:0030518 intracellular steroid hormone receptor signaling pathway IDA 11867769
genes like me logo Genes that share ontologies with MED4: view

No data available for SIGNOR curated interactions for MED4 Gene

Drugs & Compounds for MED4 Gene

(1) Drugs for MED4 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
vitamin d Pharma 1463

(1) Additional Compounds for MED4 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Steroid
genes like me logo Genes that share compounds with MED4: view

Transcripts for MED4 Gene

Unigene Clusters for MED4 Gene

Mediator complex subunit 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MED4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED4 Gene

No ASD Table

Relevant External Links for MED4 Gene

GeneLoc Exon Structure for
MED4
ECgene alternative splicing isoforms for
MED4

Expression for MED4 Gene

mRNA expression in normal human tissues for MED4 Gene

Protein differential expression in normal tissues from HIPED for MED4 Gene

This gene is overexpressed in Breast (16.9), Liver (13.5), Monocytes (11.2), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED4 Gene



SOURCE GeneReport for Unigene cluster for MED4 Gene Hs.181112

genes like me logo Genes that share expression patterns with MED4: view

Protein tissue co-expression partners for MED4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MED4 Gene

Orthologs for MED4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MED4 35
  • 91.34 (n)
  • 97.29 (a)
MED4 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED4 35
  • 91.21 (n)
  • 96.12 (a)
MED4 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med4 35
  • 87.21 (n)
  • 94.57 (a)
Med4 16
Med4 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MED4 35
  • 99.88 (n)
  • 100 (a)
MED4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med4 35
  • 87.6 (n)
  • 93.8 (a)
oppossum
(Monodelphis domestica)
Mammalia MED4 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MED4 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED4 35
  • 81.99 (n)
  • 91.49 (a)
MED4 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MED4 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med4 35
  • 80.06 (n)
  • 88.46 (a)
Str.17110 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8738 35
zebrafish
(Danio rerio)
Actinopterygii Dr.18060 35
med4 35
  • 72.08 (n)
  • 82.91 (a)
med4 36
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta MED4_ANOGA 35
  • 51.01 (n)
  • 47.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta MED4 35
  • 53.15 (n)
  • 45.95 (a)
MED4 36
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mdt-4 36
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4706 36
  • 42 (a)
OneToOne
Species with no ortholog for MED4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED4 Gene

ENSEMBL:
Gene Tree for MED4 (if available)
TreeFam:
Gene Tree for MED4 (if available)

Paralogs for MED4 Gene

(6) SIMAP similar genes for MED4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MED4: view

No data available for Paralogs for MED4 Gene

Variants for MED4 Gene

Structural Variations from Database of Genomic Variants (DGV) for MED4 Gene

Variant ID Type Subtype PubMed ID
nsv832601 CNV Gain 17160897
esv2676750 CNV Deletion 23128226

Variation tolerance for MED4 Gene

Residual Variation Intolerance Score: 52.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MED4 Gene

HapMap Linkage Disequilibrium report
MED4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MED4 Gene

Disorders for MED4 Gene

Relevant External Links for MED4

Genetic Association Database (GAD)
MED4
Human Genome Epidemiology (HuGE) Navigator
MED4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED4
genes like me logo Genes that share disorders with MED4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED4 Gene

Publications for MED4 Gene

  1. Sequential regulation of keratinocyte differentiation by 1,25(OH)2D3, VDR, and its coregulators. (PMID: 17229570) Bikle D. … Oda Y. (J. Steroid Biochem. Mol. Biol. 2007) 23 67
  2. Coactivation of estrogen receptor alpha (ER alpha)/Sp1 by vitamin D receptor interacting protein 150 (DRIP150). (PMID: 17306756) Lee J. … Safe S. (Arch. Biochem. Biophys. 2007) 23 67
  3. The DNA mismatch repair gene hMSH2 is a potent coactivator of oestrogen receptor alpha. (PMID: 15886699) Wada-Hiraike O. … Taketani Y. (Br. J. Cancer 2005) 23 67
  4. [Vitamin D nuclear receptor and its signal transduction]. (PMID: 15577143) Inui S. (Clin Calcium 2004) 23 67
  5. A novel mutation in helix 12 of the vitamin D receptor impairs coactivator interaction and causes hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia. (PMID: 12403843) Malloy P.J. … Feldman D. (Mol. Endocrinol. 2002) 23 67

Products for MED4 Gene

Sources for MED4 Gene

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