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Aliases for MED31 Gene

Aliases for MED31 Gene

  • Mediator Complex Subunit 31 2 3 4
  • Mediator Complex Subunit SOH1 3 4
  • HSOH1 3 4
  • Soh1 3 4
  • Mediator Of RNA Polymerase II Transcription, Subunit 31 Homolog (S. Cerevisiae) 2
  • Mediator Of RNA Polymerase II Transcription, Subunit 31 Homolog 3
  • Mediator Of RNA Polymerase II Transcription Subunit 31 3
  • 3110004H13Rik 3
  • CGI-125 3

External Ids for MED31 Gene

Summaries for MED31 Gene

GeneCards Summary for MED31 Gene

MED31 (Mediator Complex Subunit 31) is a Protein Coding gene. Among its related pathways are L1CAM interactions and Metabolism. GO annotations related to this gene include protein complex binding and RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED31 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED31 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED31 Gene

Genomics for MED31 Gene

Genomic Location for MED31 Gene

Start:
6,643,313 bp from pter
End:
6,651,799 bp from pter
Size:
8,487 bases
Orientation:
Minus strand

Genomic View for MED31 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MED31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED31 Gene

Regulatory Elements for MED31 Gene

Proteins for MED31 Gene

  • Protein details for MED31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3C7-MED31_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 31
    Protein Accession:
    Q9Y3C7
    Secondary Accessions:
    • B2R4L9

    Protein attributes for MED31 Gene

    Size:
    131 amino acids
    Molecular mass:
    15805 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

neXtProt entry for MED31 Gene

Proteomics data for MED31 Gene at MOPED

Post-translational modifications for MED31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MED31 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MED31 Gene

Domains for MED31 Gene

Protein Domains for MED31 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

MED31_HUMAN
Family:
  • Belongs to the Mediator complex subunit 31 family.:
    • Q9Y3C7
genes like me logo Genes that share domains with MED31: view

No data available for Gene Families for MED31 Gene

Function for MED31 Gene

Molecular function for MED31 Gene

UniProtKB/Swiss-Prot Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

Gene Ontology (GO) - Molecular Function for MED31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IEA --
GO:0005515 protein binding IPI 15383276
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with MED31: view
genes like me logo Genes that share phenotypes with MED31: view

miRNA for MED31 Gene

miRTarBase miRNAs that target MED31

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MED31 Gene

Localization for MED31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED31 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED31 Gene COMPARTMENTS Subcellular localization image for MED31 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MED31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0016592 mediator complex IEA --
genes like me logo Genes that share ontologies with MED31: view

Pathways for MED31 Gene

genes like me logo Genes that share pathways with MED31: view

Pathways by source for MED31 Gene

Gene Ontology (GO) - Biological Process for MED31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006461 protein complex assembly IEA --
genes like me logo Genes that share ontologies with MED31: view

Transcripts for MED31 Gene

mRNA/cDNA for MED31 Gene

Unigene Clusters for MED31 Gene

Mediator complex subunit 31:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MED31 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2: - -
SP3:

Relevant External Links for MED31 Gene

GeneLoc Exon Structure for
MED31
ECgene alternative splicing isoforms for
MED31

Expression for MED31 Gene

mRNA expression in normal human tissues for MED31 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED31 Gene

SOURCE GeneReport for Unigene cluster for MED31 Gene Hs.567493

genes like me logo Genes that share expressions with MED31: view

Orthologs for MED31 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MED31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED31 36
  • 98.98 (n)
  • 98.47 (a)
MED31 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MED31 36
  • 93.64 (n)
  • 98.47 (a)
MED31 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED31 36
  • 85.9 (n)
  • 89.15 (a)
MED31 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med31 36
  • 91.6 (n)
  • 97.71 (a)
Med31 16
Med31 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MED31 37
  • 36 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med31 36
  • 93.64 (n)
  • 97.71 (a)
chicken
(Gallus gallus)
Aves MED31 36
  • 85.19 (n)
  • 96.3 (a)
MED31 37
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8668 36
tropical clawed frog
(Silurana tropicalis)
Amphibia med31 36
  • 81.89 (n)
  • 94.49 (a)
Str.4402 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.47 36
zebrafish
(Danio rerio)
Actinopterygii med31 36
  • 76.97 (n)
  • 87.27 (a)
med31 37
  • 80 (a)
OneToOne
wufa04d01 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002258 36
  • 68.18 (n)
  • 75.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta MED31 37
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mdt-31 36
  • 63.4 (n)
  • 64.71 (a)
mdt-31 37
  • 41 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOH1 37
  • 31 (a)
OneToOne
SOH1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons MED31 36
  • 54.6 (n)
  • 49.52 (a)
rice
(Oryza sativa)
Liliopsida Os10g0564100 36
  • 54.74 (n)
  • 49.54 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5791 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 56 (a)
OneToOne
Species with no ortholog for MED31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED31 Gene

ENSEMBL:
Gene Tree for MED31 (if available)
TreeFam:
Gene Tree for MED31 (if available)

Paralogs for MED31 Gene

No data available for Paralogs for MED31 Gene

Variants for MED31 Gene

Sequence variations from dbSNP and Humsavar for MED31 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs12767 -- 6,645,841(+) TAAAA(C/T)AGGCA intron-variant
rs1053376 -- 6,645,737(-) aggaa(G/T)tatat intron-variant
rs2871289 -- 6,648,300(+) actca(C/T)gagaa intron-variant
rs4796342 -- 6,648,940(+) CTACA(G/T)ACATA intron-variant
rs7211519 -- 6,646,269(+) gtgaa(C/G)aaaat intron-variant

Relevant External Links for MED31 Gene

HapMap Linkage Disequilibrium report
MED31

No data available for Structural Variations from Database of Genomic Variants (DGV) for MED31 Gene

Disorders for MED31 Gene

No disorders were found for MED31 Gene.

No data available for UniProtKB/Swiss-Prot for MED31 Gene

Publications for MED31 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. (PMID: 10024883) Gu W. … Roeder R.G. (Mol. Cell 1999) 3 4 23
  3. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PMID: 12584197) Sato S. … Conaway J.W. (J. Biol. Chem. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 3 4

Products for MED31 Gene

Sources for MED31 Gene

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