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Aliases for MED31 Gene

Aliases for MED31 Gene

  • Mediator Complex Subunit 31 2 3 4 5
  • Mediator Complex Subunit SOH1 3 4
  • HSOH1 3 4
  • Soh1 3 4
  • Mediator Of RNA Polymerase II Transcription, Subunit 31 Homolog (S. Cerevisiae) 2
  • Mediator Of RNA Polymerase II Transcription, Subunit 31 Homolog 3
  • 3110004H13Rik 3
  • CGI-125 3

External Ids for MED31 Gene

Previous GeneCards Identifiers for MED31 Gene

  • GC17M006488
  • GC17M006489
  • GC17M006546
  • GC17M006441

Summaries for MED31 Gene

GeneCards Summary for MED31 Gene

MED31 (Mediator Complex Subunit 31) is a Protein Coding gene. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include protein complex binding and RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED31 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED31 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED31 Gene

Genomics for MED31 Gene

Regulatory Elements for MED31 Gene

Genomic Location for MED31 Gene

Chromosome:
17
Start:
6,643,313 bp from pter
End:
6,651,634 bp from pter
Size:
8,322 bases
Orientation:
Minus strand

Genomic View for MED31 Gene

Genes around MED31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED31 Gene

Proteins for MED31 Gene

  • Protein details for MED31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3C7-MED31_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 31
    Protein Accession:
    Q9Y3C7
    Secondary Accessions:
    • B2R4L9

    Protein attributes for MED31 Gene

    Size:
    131 amino acids
    Molecular mass:
    15805 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

neXtProt entry for MED31 Gene

Proteomics data for MED31 Gene at MOPED

Post-translational modifications for MED31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MED31 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MED31

No data available for DME Specific Peptides for MED31 Gene

Domains & Families for MED31 Gene

Gene Families for MED31 Gene

Protein Domains for MED31 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MED31 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3C7

UniProtKB/Swiss-Prot:

MED31_HUMAN :
  • Belongs to the Mediator complex subunit 31 family.
Family:
  • Belongs to the Mediator complex subunit 31 family.
genes like me logo Genes that share domains with MED31: view

Function for MED31 Gene

Molecular function for MED31 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IEA --
genes like me logo Genes that share ontologies with MED31: view
genes like me logo Genes that share phenotypes with MED31: view

Animal Model Products

miRNA for MED31 Gene

miRTarBase miRNAs that target MED31

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED31 Gene

Localization for MED31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED31 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED31 Gene COMPARTMENTS Subcellular localization image for MED31 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MED31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IEA --
genes like me logo Genes that share ontologies with MED31: view

Pathways & Interactions for MED31 Gene

genes like me logo Genes that share pathways with MED31: view

Gene Ontology (GO) - Biological Process for MED31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA,IBA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with MED31: view

No data available for SIGNOR curated interactions for MED31 Gene

Drugs & Compounds for MED31 Gene

No Compound Related Data Available

Transcripts for MED31 Gene

Unigene Clusters for MED31 Gene

Mediator complex subunit 31:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MED31 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2: - -
SP3:

Relevant External Links for MED31 Gene

GeneLoc Exon Structure for
MED31
ECgene alternative splicing isoforms for
MED31

Expression for MED31 Gene

mRNA expression in normal human tissues for MED31 Gene

Protein differential expression in normal tissues from HIPED for MED31 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.3), NK cells (8.0), and Fetal testis (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED31 Gene



SOURCE GeneReport for Unigene cluster for MED31 Gene Hs.567493

genes like me logo Genes that share expression patterns with MED31: view

Protein tissue co-expression partners for MED31 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MED31 Gene

Orthologs for MED31 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MED31 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MED31 35
  • 93.64 (n)
  • 98.47 (a)
MED31 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED31 35
  • 85.9 (n)
  • 89.15 (a)
MED31 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med31 35
  • 91.6 (n)
  • 97.71 (a)
Med31 16
Med31 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MED31 35
  • 98.98 (n)
  • 98.47 (a)
MED31 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med31 35
  • 93.64 (n)
  • 97.71 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia MED31 36
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED31 35
  • 85.19 (n)
  • 96.3 (a)
MED31 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med31 35
  • 81.89 (n)
  • 94.49 (a)
Str.4402 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8668 35
zebrafish
(Danio rerio)
Actinopterygii med31 35
  • 76.97 (n)
  • 87.27 (a)
wufa04d01 35
med31 36
  • 80 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.47 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002258 35
  • 68.18 (n)
  • 75.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta MED31 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mdt-31 35
  • 63.4 (n)
  • 64.71 (a)
mdt-31 36
  • 41 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOH1 36
  • 31 (a)
OneToOne
SOH1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons MED31 35
  • 54.6 (n)
  • 49.52 (a)
rice
(Oryza sativa)
Liliopsida Os10g0564100 35
  • 54.74 (n)
  • 49.54 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5791 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToOne
Species with no ortholog for MED31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED31 Gene

ENSEMBL:
Gene Tree for MED31 (if available)
TreeFam:
Gene Tree for MED31 (if available)

Paralogs for MED31 Gene

No data available for Paralogs for MED31 Gene

Variants for MED31 Gene

Sequence variations from dbSNP and Humsavar for MED31 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs12767 -- 6,645,841(+) TAAAA(C/T)AGGCA intron-variant
rs1053376 -- 6,645,737(-) aggaa(G/T)tatat intron-variant
rs2871289 -- 6,648,300(+) actca(C/T)gagaa intron-variant
rs4796342 -- 6,648,940(+) CTACA(G/T)ACATA intron-variant
rs7214691 -- 6,645,410(+) ctgtg(A/G)tacta intron-variant

Variation tolerance for MED31 Gene

Residual Variation Intolerance Score: 45.3% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MED31 Gene

HapMap Linkage Disequilibrium report
MED31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MED31 Gene

Disorders for MED31 Gene

Relevant External Links for MED31

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED31

No disorders were found for MED31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED31 Gene

Publications for MED31 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 67
  2. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. (PMID: 10024883) Gu W. … Roeder R.G. (Mol. Cell 1999) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. (PMID: 23322298) Davis M.A. … Clurman B.E. (Genes Dev. 2013) 3
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3

Products for MED31 Gene

Sources for MED31 Gene

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