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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MED31 Gene

protein-coding   GIFtS: 50
GCID: GC17M006546

Mediator Complex Subunit 31

(Previous names: mediator of RNA polymerase II transcription, subunit 31...)
  Search for MED31
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mediator Complex Subunit 311 2 3     Soh12
Mediator Complex Subunit SOH12 3     Mediator Of RNA Polymerase II Transcription Subunit 312
hSOH12 3     Mediator Of RNA Polymerase II Transcription, Subunit 31 Homolog2
Mediator Of RNA Polymerase II Transcription, Subunit 31 Homolog (S.
Cerevisiae)1
     SOH13
3110004H13Rik2     

External Ids:    HGNC: 242601   Entrez Gene: 510032   Ensembl: ENSG000001085907   UniProtKB: Q9Y3C73   

Export aliases for MED31 gene to outside databases

Previous GC identifers: GC17M006488 GC17M006489 GC17M006441


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MED31 Gene: 
MED31 (mediator complex subunit 31) is a protein-coding gene. Among its related super-pathways are Gene Expression and Axon guidance. GO annotations related to this gene include RNA polymerase II transcription cofactor activity and protein complex binding.

UniProtKB/Swiss-Prot: MED31_HUMAN, Q9Y3C7
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED31 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MED31 gene promoter:
         Sox5   AML1a   Pax-2   AP-4   Cdc5   N-Myc   STAT3   Msx-1   ZID   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED31 promoter sequence
   Search SABiosciences Chromatin IP Primers for MED31

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED31


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

MED31 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED31 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M006546:  view genomic region     (about GC identifiers)

Start:
6,546,633 bp from pter      End:
6,554,954 bp from pter
Size:
8,322 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MED31_HUMAN, Q9Y3C7 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 31  
Size: 131 amino acids; 15805 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Subcellular location: Nucleus (Probable)
Secondary accessions: B2R4L9

Explore the universe of human proteins at neXtProt for MED31: NX_Q9Y3C7

Explore proteomics data for MED31 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y3C7

  • MED31 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MED31 Protein Expression
    REFSEQ proteins: NP_057144.1  
    ENSEMBL proteins: 
     ENSP00000225728   ENSP00000458248   ENSP00000459723  
    Reactome Protein details: Q9Y3C7
    Human Recombinant Protein Products for MED31: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MED31
    OriGene Protein Over-expression Lysate for MED31
    OriGene MassSpec for MED31 
    OriGene Custom Protein Services for MED31
    GenScript Custom Purified and Recombinant Proteins Services for MED31
    Novus Biologicals MED31 Protein
    Novus Biologicals MED31 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MED31 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0016592mediator complex IEA--

    MED31 for ontologies           About GeneDecksing



    MED31 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Custom Antibody Services for MED31
    GenScript Custom Superior Antibodies Services for MED31
    Novus Biologicals MED31 Antibodies
    Abcam antibodies for MED31
    Cloud-Clone Corp. Antibodies for MED31 
    Search ThermoFisher Antibodies for MED31
    LSBio Antibodies in human, mouse, rat for MED31 

    Assay Products for MED31: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED31
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED31
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED31 
    Cloud-Clone Corp. CLIAs for MED31


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008831 Mediator_Med31

    Graphical View of Domain Structure for InterPro Entry Q9Y3C7

    ProtoNet protein and cluster: Q9Y3C7

    1 Blocks protein domain: IPB008831 SOH1

    UniProtKB/Swiss-Prot: MED31_HUMAN, Q9Y3C7
    Similarity: Belongs to the Mediator complex subunit 31 family


    MED31 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED31_HUMAN, Q9Y3C7
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IEA--
    GO:0005515protein binding IPI15383276
    GO:0032403protein complex binding IEA--
         
    MED31 for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 1 allele(MGI details for Med31):
     cardiovascular system  cellular  craniofacial  embryogenesis  growth/size 
     hearing/vestibular/ear  homeostasis/metabolism  integument  limbs/digits/tail  mortality/aging 
     nervous system  skeleton 

    MED31 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MED31 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MED31

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MED31 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MED31 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED31
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MED31:
    hsa-miR-1304 hsa-miR-548m hsa-miR-520d-5p hsa-miR-518a-5p hsa-miR-524-5p hsa-miR-1208 hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidMED31 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MED31
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED31

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED31
    Sirion Biotech Customized adenovirus for overexpression of MED31

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MED31 (see all 7)
    OriGene ORF clones in mouse, rat for MED31
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED31 (NM_016060)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED31
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED31
    Sirion Biotech Customized lentivirus for stable overexpression of MED31 
                         Customized lentivirus expression plasmids for stable overexpression of MED31 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MED31
    Search LifeMap BioReagents cell lines for MED31
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED31


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MED31 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    2Axon guidance
    Developmental Biology0.69
    3Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes1.00
    4Transcriptional Regulation of White Adipocyte Differentiation
    Transcriptional Regulation of White Adipocyte Differentiation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MED31
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    1 GeneGo (Thomson Reuters) Pathway for MED31
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    4        Reactome Pathways for MED31
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation
    Generic Transcription Pathway
    Gene Expression



    MED31 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MED31

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/201 Interacting proteins for MED31 (Q9Y3C71, 2, 3 ENSP000002257284) via UniProtKB, MINT, STRING, and/or I2D (see all 201)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GADD45GO952571, 2, 3, ENSP000002525064EBI-394707,EBI-448202 MINT-3979222 MINT-3981770 I2D: score=5 STRING: ENSP00000252506
    SELENBP1Q132282, 3, ENSP000003578614MINT-65168 MINT-8270055 I2D: score=5 STRING: ENSP00000357861
    MOB4Q9Y3A32, 3, ENSP000003157024MINT-65842 I2D: score=5 STRING: ENSP00000315702
    ZBTB45Q96K622, 3, ENSP000003466034MINT-65223 I2D: score=5 STRING: ENSP00000346603
    SMN1Q166372, 3MINT-8271278 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006461protein complex assembly IEA--
    GO:0010467gene expression TAS--

    MED31 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MED31

    Search CenterWatch for drugs/clinical trials and news about MED31

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MED31 gene: 
    NM_016060.2  

    Unigene Cluster for MED31:

    Mediator complex subunit 31
    Hs.567493  [show with all ESTs]
    Unigene Representative Sequence: NM_016060
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225728(uc002gdg.4 uc002gdh.4) ENST00000575197 ENST00000574128
    ENST00000575519
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED31
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MED31:
    hsa-miR-1304 hsa-miR-548m hsa-miR-520d-5p hsa-miR-518a-5p hsa-miR-524-5p hsa-miR-1208 hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidMED31 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MED31
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED31
    Clone
    Products:
         
    OriGene clones in human, mouse for MED31 (see all 7)
    OriGene ORF clones in mouse, rat for MED31
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED31 (NM_016060)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED31
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED31
    Sirion Biotech Customized lentivirus for stable overexpression of MED31 
                         Customized lentivirus expression plasmids for stable overexpression of MED31 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MED31
    OriGene qSTAR qPCR primer pairs in human, mouse for MED31
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED31
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED31
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED31

    Additional mRNA sequence: 

    AF151883.1 AK130946.1 AK311875.1 BC012539.1 

    9 DOTS entries:

    DT.97820955  DT.100806063  DT.100806066  DT.92435559  DT.120964630  DT.433635  DT.91649287  DT.91818049 
    DT.95295881 

    24/87 AceView cDNA sequences (see all 87):

    BM979841 AA045335 AF151883 BC012539 AW205480 N64393 BE045498 AA702488 
    NM_016060 AI097504 BX441300 AI279091 N92189 BQ187217 AI371078 AK130946 
    BM685273 BX119047 AI129575 AA975693 AI078621 BU180985 BQ021648 AA442221 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MED31    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
    SP1:                          -               
    SP2:                    -     -               
    SP3:                                          


    ECgene alternative splicing isoforms for MED31

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MED31 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MED31 Expression
    About this image


    See MED31 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MED31

    SOURCE GeneReport for Unigene cluster: Hs.567493
        SABiosciences Custom PCR Arrays for MED31
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MED31
    OriGene qSTAR qPCR primer pairs in human, mouse for MED31
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED31
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED31
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED31
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED31

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MED31 gene from 9/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med311 , 5 mediator of RNA polymerase II transcription, subunit more1, 5 91.6(n)1
    97.71(a)1
      11 (43.93 cM)5
    672791  NM_026068.21  NP_080344.21 
     722117245 
    chicken
    (Gallus gallus)
    Aves MED311 mediator complex subunit 31 83.88(n)
    95.08(a)
      417679  XM_415924.3  XP_415924.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.86682 Xenopus laevis transcribed sequence with strong similarity more 81.42(n)    BJ625498.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa04d012 wufa04d01 78.28(n)   334816  BM534139.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED311 Mediator complex subunit 31 64.74(n)
    70.25(a)
      40577  NM_169013.2  NP_730861.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mdt-311 Protein MDT-31 61.21(n)
    62.73(a)
      185213  NM_060012.1  NP_492413.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SOH1(YGL127C)4 Subunit of the RNA polymerase II mediator complex; more   --   7(270775-270392) 852750  NP_011388.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MED311 mediator of RNA polymerase II transcription subunit more 54.6(n)
    49.52(a)
      832113  NM_121998.4  NP_197491.2 
    rice
    (Oryza sativa)
    Liliopsida Os07g01646001 hypothetical protein 56(n)
    51(a)
      4342476  NM_001065496.1  NP_001058961.1 


    ENSEMBL Gene Tree for MED31 (if available)
    TreeFam Gene Tree for MED31 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/93 SNPs in MED31 are shown (see all 93)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs72154941,2
    C,F,A,H--6548480(+) acaagT/Caaata 1 -- int114Minor allele frequency- C:0.26NA WA CSA EA 381
    rs789294851,2
    C,F--6548503(+) GGACAG/ACCAAA 1 -- int12Minor allele frequency- A:0.11CSA WA 120
    rs1506642851,2
    --6548511(+) AAATTG/TCTGGC 1 -- int10--------
    rs1388530931,2
    --6548624(+) TATAGA/TCATAG 1 -- int10--------
    rs352070731,2
    C,F--6548693(+) GAGCTT/CTGTGT 1 -- int111Minor allele frequency- C:0.38NA WA CSA EA 379
    rs72146911,2
    C,F,A,H--6548730(+) ctgtgG/Atacta 1 -- int125Minor allele frequency- A:0.27NS EA NA WA 2778
    rs1913064731,2
    --6548845(+) TTACGC/TAGTGC 1 -- int10--------
    rs344473531,2
    C,F--6548893(+) AAGTAT/GTCAGG 1 -- int17Minor allele frequency- G:0.22NA WA CSA EA 366
    rs1837780271,2
    --6548944(+) CTTAGC/TGCAAG 1 -- int10--------
    rs1892950441,2
    --6549006(+) CCACAC/GTAAAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for MED31 (6546633 - 6554954 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MED31: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MED31
    DNA2.0 Custom Variant and Variant Library Synthesis for MED31

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MED31 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with MED31)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    2. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. (PubMed id 10024883)1, 2, 9 Gu W.... Roeder R.G. (1999)
    3. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S....Conaway R.C. (2004)
    7. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PubMed id 12584197)1, 2 Sato S....Conaway J.W. (2003)
    8. The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13 L and regulates CDK8 module association with Mediator. (PubMed id 23322298)1 Davis M.A....Clurman B.E. (2013)
    9. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51003 HGNC: 24260 AceView: CGI-125 Ensembl:ENSG00000108590 euGenes: HUgn51003
    ECgene: MED31 H-InvDB: MED31

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MED31 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MED31 gene:
    Search GeneIP for patents involving MED31

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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