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MED30 Gene

protein-coding   GIFtS: 53
GCID: GC08P118603

Mediator Complex Subunit 30

(Previous name: thyroid hormone receptor associated protein 6)
(Previous symbol: THRAP6)
  Search for MED30
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mediator Complex Subunit 301 2 3     TRAP/Mediator Complex Component TRAP252 3
THRAP61 2 3 5     MED30S2
TRAP252 3 5     Mediator Of RNA Polymerase II Transcription Subunit 302
Thyroid Hormone Receptor Associated Protein 61 2     Putative Mediator Of RNA Polymerase II Transcription Subunit 302
Thyroid Hormone Receptor-Associated Protein 62 3     Trap253
Thyroid Hormone Receptor-Associated Protein Complex 25 KDa Component2 3     

External Ids:    HGNC: 230321   Entrez Gene: 903902   Ensembl: ENSG000001647587   OMIM: 6102375   UniProtKB: Q96HR33   

Export aliases for MED30 gene to outside databases

Previous GC identifer: GC08P113859


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MED30 Gene:
The multiprotein TRAP/Mediator complex facilitates gene expression through a wide variety of transcriptional
activators. MED30 is a component of this complex that appears to be metazoan specific (Baek et al., 2002 (PubMed
11909976)).(supplied by OMIM, Nov 2010)

GeneCards Summary for MED30 Gene:
MED30 (mediator complex subunit 30) is a protein-coding gene. GO annotations related to this gene include receptor activity and ligand-dependent nuclear receptor transcription coactivator activity.

UniProtKB/Swiss-Prot: MED30_HUMAN, Q96HR3
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED30 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MED30 gene promoter:
         HFH-3   TBP   AML1a   Olf-1   CUTL1   AREB6   POU2F1   POU2F1a   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED30 promoter sequence
   Search Chromatin IP Primers for MED30

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MED30


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.11   Ensembl cytogenetic band:  8q24.11   HGNC cytogenetic band: 8q24.11

MED30 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED30 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P118603:  view genomic region     (about GC identifiers)

Start:
118,532,952 bp from pter      End:
118,552,501 bp from pter
Size:
19,550 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MED30_HUMAN, Q96HR3 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 30  
Size: 178 amino acids; 20277 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Secondary accessions: C6GKU9
Alternative splicing: 2 isoforms:  Q96HR3-1   Q96HR3-2   

Explore the universe of human proteins at neXtProt for MED30: NX_Q96HR3

Explore proteomics data for MED30 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys157
  • Modification sites at PhosphoSitePlus

  • See MED30 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001269915.1  NP_542382.1  

    ENSEMBL proteins: 
     ENSP00000297347   ENSP00000431051  
    Reactome Protein details: Q96HR3

    MED30 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for MED30
    OriGene Protein Over-expression Lysate for MED30
    OriGene MassSpec for MED30
    OriGene Custom Protein Services for MED30
    GenScript Custom Purified and Recombinant Proteins Services for MED30
    Novus Biologicals MED30 Protein
    Novus Biologicals MED30 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MED30

     
    Search eBioscience for Proteins for MED30 

    MED30 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Custom Antibody Services for MED30
    Novus Biologicals MED30 Antibodies
    Abcam antibodies for MED30
    Cloud-Clone Corp. Antibodies for MED30
    Search ThermoFisher Antibodies for MED30
    LSBio Antibodies in human, mouse, rat for MED30

    MED30 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED30
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED30
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED30
    Cloud-Clone Corp. CLIAs for MED30
    Search eBioscience for ELISAs for MED30 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR021019 Mediator_Med30_met

    Graphical View of Domain Structure for InterPro Entry Q96HR3

    ProtoNet protein and cluster: Q96HR3

    UniProtKB/Swiss-Prot: MED30_HUMAN, Q96HR3
    Similarity: Belongs to the Mediator complex subunit 30 family


    Find genes that share domains with MED30           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED30_HUMAN, Q96HR3
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IDA10198638
    GO:0003712transcription cofactor activity IDA12218053
    GO:0004872receptor activity IDA12218053
    GO:0005515protein binding IPI--
    GO:0030374ligand-dependent nuclear receptor transcription coactivator activity NAS10235266
         
    Find genes that share ontologies with MED30           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for MED30:
     Decreased viability  Increased circadian period len  Synthetic lethal with c-Myc af 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Med30):
     cardiovascular system  cellular  growth/size/body  hematopoietic system  mortality/aging 
     muscle 

    Find genes that share phenotypes with MED30           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MED30
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MED30

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MED30
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MED30

    miRNA
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    Block miRNA regulation of human, mouse, rat MED30 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MED30
    SwitchGear 3'UTR luciferase reporter plasmidMED30 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MED30
    Predesigned siRNA for gene silencing in human, mouse, rat MED30

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED30

    Clone
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    OriGene clones in human, mouse for MED30 (see all 7)
    OriGene ORF clones in mouse, rat for MED30
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED30 (NM_080651)
    Sino Biological Human cDNA Clone for MED30
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED30
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED30

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MED30
    Browse ESI BIO Cell Lines and PureStem Progenitors for MED30 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED30


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MED30_HUMAN, Q96HR3: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    plasma membrane2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10235267
    GO:0005654nucleoplasm TAS--
    GO:0016592mediator complex IDA10198638

    Find genes that share ontologies with MED30           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MED30 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    4L1CAM interactions
    Developmental Biology0.63
    5Transcription Ligand Dependent Transcription of Retinoid Target genes
    Transcription Ligand Dependent Transcription of Retinoid Target genes


    Find genes that share SuperPaths with MED30           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for MED30
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    3 Reactome Pathways for MED30
        Transcriptional regulation of white adipocyte differentiation
    Generic Transcription Pathway
    PPARA activates gene expression


    1 Kegg Pathway  (Kegg details for MED30):
        Thyroid hormone signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MED30
    Interactions:

        Search GeneGlobe Interaction Network for MED30

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MED30 (Q96HR33 ENSP000002973474) via UniProtKB, MINT, STRING, and/or I2D (see all 126)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000227333Q96KQ73, ENSP000003973234I2D: score=1 STRING: ENSP00000397323
    EHMT2Q96KQ73I2D: score=1 
    ENSG00000206376Q96KQ73I2D: score=1 
    ENSG00000232045Q96KQ73I2D: score=1 
    ENSG00000236759Q96KQ73I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA10198638
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0019827stem cell maintenance IEA--
    GO:0030518intracellular steroid hormone receptor signaling pathway IDA11867769

    Find genes that share ontologies with MED30           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MED30



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MED30 gene (2 alternative transcripts): 
    NM_001282986.1  NM_080651.3  

    Unigene Cluster for MED30:

    Mediator complex subunit 30
    Hs.492612  [show with all ESTs]
    Unigene Representative Sequence: BM458612
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297347(uc003yoj.3 uc011lib.2) ENST00000519879 ENST00000522839
    ENST00000519391
    miRNA
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    Block miRNA regulation of human, mouse, rat MED30 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidMED30 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MED30
    Predesigned siRNA for gene silencing in human, mouse, rat MED30
    Clone
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    OriGene clones in human, mouse for MED30 (see all 7)
    OriGene ORF clones in mouse, rat for MED30
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED30 (NM_080651)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED30
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED30
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MED30
    OriGene qSTAR qPCR primer pairs in human, mouse for MED30
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED30
      QuantiTect SYBR Green Assays in human, mouse, rat MED30
      QuantiFast Probe-based Assays in human, mouse, rat MED30

    Additional mRNA sequence: 

    AY083305.1 BC008226.1 FM179284.1 

    4 DOTS entries:

    DT.220335  DT.86844569  DT.91697509  DT.91697498 

    Selected AceView cDNA sequences (see all 67):

    BM458612 CF529815 AW103865 CR602778 AI656945 AW162597 AI767024 CB305552 
    AI184166 AY083305 AA810068 BX281284 BE618444 CN483837 AA573111 AW439215 
    AW614040 AW160991 BI769041 BI757832 AA812233 AA757146 BX420298 BM972663 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MED30 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTGAATAA
    MED30 Expression
    About this image

    MED30 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MED30 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.492612

    UniProtKB/Swiss-Prot: MED30_HUMAN, Q96HR3
    Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle

        Custom PCR Arrays for MED30
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    QuantiFast Probe-based Assays in human, mouse, rat MED30
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED30

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MED30 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med301 , 5 mediator complex subunit 301, 5 90.07(n)1
    94.94(a)1
      15 (19.95 cM)5
    697901  NM_027212.21  NP_081488.11 
     527124455 
    chicken
    (Gallus gallus)
    Aves MED301 mediator complex subunit 30 80.79(n)
    88.7(a)
      420284  NM_001277436.1  NP_001264365.1 
    lizard
    (Anolis carolinensis)
    Reptilia MED306
    mediator complex subunit 30
    88(a)
    1 ↔ 1
    4(6865287-6890521)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.290362 Xenopus laevis transcribed sequence with moderate similarity more 74.56(n)    48036292 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731132 hypothetical protein MGC73113 76.78(n)   393690  BC059478.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED301 Mediator complex subunit 30 55.41(n)
    41.4(a)
      38078  NM_138202.4  NP_612046.1 


    ENSEMBL Gene Tree for MED30 (if available)
    TreeFam Gene Tree for MED30 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MED30 (see all 428)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1140135651,2
    F--118531395(+) GTCCTC/AACACT 1 -- us2k11Minor allele frequency- A:0.12WA 118
    rs1442925921,2
    C--118531404(+) CTGAAC/TTTCTT 1 -- us2k10--------
    rs1911522881,2
    --118531448(+) CTTCAC/GGTGTT 1 -- us2k10--------
    rs625211981,2
    C--118531470(+) TCCTCG/ATCCTC 1 -- us2k14Minor allele frequency- A:0.14NA WA EA 360
    rs1830526281,2
    --118531585(+) TATCAG/TGAACT 1 -- us2k10--------
    rs1876118281,2
    --118531587(+) TCAGGA/GACTTT 1 -- us2k10--------
    rs726721261,2
    C,F--118531669(+) GTTTGT/GTCAGT 1 -- us2k13Minor allele frequency- G:0.06WA NA EA 358
    rs772356921,2
    F--118531676(+) CAGTAC/GGCTAT 1 -- us2k10--------
    rs1912786791,2
    C--118531708(+) CATAAC/TAGGTG 1 -- us2k10--------
    rs2003266641,2
    --118531917(+) TGAAC-/AGTAAG
            
    AGTAA
    1 -- cds10--------

    HapMap Linkage Disequilibrium report for MED30 (118532952 - 118552501 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MED30:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831436CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MED30
    DNA2.0 Custom Variant and Variant Library Synthesis for MED30

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610237    OMIM disorders: --


    Find genes that share disorders with MED30           About GenesLikeMe

    Genetic Association Database (GAD): MED30

    Export disorders for MED30 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MED30 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with MED30)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. (PubMed id 22446961)1, 4 Lee Y.C....Wu J.Y. (Nat. Genet. 2012)
    2. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (Mol. Cell 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S.... Conaway R.C. (Mol. Cell 2004)
    5. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PubMed id 12584197)1, 2 Sato S....Conaway J.W. (J. Biol. Chem. 2003)
    6. Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s. (PubMed id 11909976)1, 2 Baek H.J.... Roeder R.G. (Mol. Cell. Biol. 2002)
    7. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    8. The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. (PubMed id 23322298)1 Davis M.A....Clurman B.E. (amp 2013)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Human mediator subunit MED26 functions as a docking site for transcription elongation factors. (PubMed id 21729782)1 Takahashi H....Conaway J.W. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90390 HGNC: 23032 AceView: THRAP6 Ensembl:ENSG00000164758 euGenes: HUgn90390
    ECgene: MED30 Kegg: 90390 H-InvDB: MED30

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MED30 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MED30 gene:
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    GeneCards and IP:
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