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Aliases for MED30 Gene

Aliases for MED30 Gene

  • Mediator Complex Subunit 30 2 3 4
  • THRAP6 3 4 6
  • TRAP25 3 4 6
  • Thyroid Hormone Receptor-Associated Protein Complex 25 KDa Component 3 4
  • Thyroid Hormone Receptor Associated Protein 6 2 3
  • Thyroid Hormone Receptor-Associated Protein 6 3 4
  • TRAP/Mediator Complex Component TRAP25 3 4
  • Putative Mediator Of RNA Polymerase II Transcription Subunit 30 3
  • Mediator Of RNA Polymerase II Transcription Subunit 30 3
  • MED30S 3

External Ids for MED30 Gene

Previous HGNC Symbols for MED30 Gene

  • THRAP6

Previous GeneCards Identifiers for MED30 Gene

  • GC08P118603
  • GC08P113859

Summaries for MED30 Gene

Entrez Gene Summary for MED30 Gene

  • The multiprotein TRAP/Mediator complex facilitates gene expression through a wide variety of transcriptional activators. MED30 is a component of this complex that appears to be metazoan specific (Baek et al., 2002 [PubMed 11909976]).[supplied by OMIM, Nov 2010]

GeneCards Summary for MED30 Gene

MED30 (Mediator Complex Subunit 30) is a Protein Coding gene. Among its related pathways are L1CAM interactions and Metabolism. GO annotations related to this gene include receptor activity and ligand-dependent nuclear receptor transcription coactivator activity.

UniProtKB/Swiss-Prot for MED30 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED30 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED30 Gene

Genomics for MED30 Gene

Regulatory Elements for MED30 Gene

Genomic Location for MED30 Gene

Start:
117,520,713 bp from pter
End:
117,540,262 bp from pter
Size:
19,550 bases
Orientation:
Plus strand

Genomic View for MED30 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MED30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED30 Gene

Proteins for MED30 Gene

  • Protein details for MED30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HR3-MED30_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 30
    Protein Accession:
    Q96HR3
    Secondary Accessions:
    • C6GKU9

    Protein attributes for MED30 Gene

    Size:
    178 amino acids
    Molecular mass:
    20277 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

    Alternative splice isoforms for MED30 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED30 Gene

Proteomics data for MED30 Gene at MOPED

Post-translational modifications for MED30 Gene

  • Ubiquitination at Lys157
  • Modification sites at PhosphoSitePlus

Other Protein References for MED30 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MED30 Gene

Domains for MED30 Gene

Protein Domains for MED30 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED30 Gene

Graphical View of Domain Structure for InterPro Entry

Q96HR3

UniProtKB/Swiss-Prot:

MED30_HUMAN :
  • Q96HR3
Family:
  • Belongs to the Mediator complex subunit 30 family.
genes like me logo Genes that share domains with MED30: view

No data available for Gene Families for MED30 Gene

Function for MED30 Gene

Molecular function for MED30 Gene

UniProtKB/Swiss-Prot Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IDA 10198638
GO:0003712 transcription cofactor activity IDA 12218053
GO:0004872 receptor activity IDA 12218053
GO:0005515 protein binding IPI 21784977
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity NAS 10235266
genes like me logo Genes that share ontologies with MED30: view
genes like me logo Genes that share phenotypes with MED30: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MED30 Gene

Localization for MED30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED30 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED30 Gene COMPARTMENTS Subcellular localization image for MED30 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MED30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10235267
GO:0005654 nucleoplasm TAS --
GO:0016592 mediator complex IDA 10198638
genes like me logo Genes that share ontologies with MED30: view

Pathways for MED30 Gene

genes like me logo Genes that share pathways with MED30: view

Gene Ontology (GO) - Biological Process for MED30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 10198638
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
GO:0019827 stem cell maintenance IEA --
GO:0030518 intracellular steroid hormone receptor signaling pathway IDA 11867769
genes like me logo Genes that share ontologies with MED30: view

Transcripts for MED30 Gene

Unigene Clusters for MED30 Gene

Mediator complex subunit 30:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MED30 Gene

No ASD Table

Relevant External Links for MED30 Gene

GeneLoc Exon Structure for
MED30
ECgene alternative splicing isoforms for
MED30

Expression for MED30 Gene

mRNA expression in normal human tissues for MED30 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED30 Gene

SOURCE GeneReport for Unigene cluster for MED30 Gene Hs.492612

mRNA Expression by UniProt/SwissProt for MED30 Gene

Q96HR3-MED30_HUMAN
Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
genes like me logo Genes that share expressions with MED30: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MED30 Gene

Orthologs for MED30 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED30 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED30 35
  • 100 (n)
  • 100 (a)
MED30 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MED30 35
  • 92.92 (n)
  • 97.95 (a)
MED30 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED30 35
  • 94.01 (n)
  • 97.19 (a)
MED30 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med30 35
  • 90.07 (n)
  • 94.94 (a)
Med30 16
Med30 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MED30 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med30 35
  • 89.28 (n)
  • 95.1 (a)
chicken
(Gallus gallus)
Aves MED30 35
  • 80.79 (n)
  • 88.7 (a)
MED30 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MED30 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29036 35
tropical clawed frog
(Silurana tropicalis)
Amphibia med30 35
  • 74.91 (n)
  • 83.71 (a)
Str.16066 35
zebrafish
(Danio rerio)
Actinopterygii med30 35
  • 72.12 (n)
  • 80.7 (a)
med30 36
  • 78 (a)
OneToOne
zgc73113 35
fruit fly
(Drosophila melanogaster)
Insecta MED30 35
  • 55.41 (n)
  • 41.4 (a)
MED30 36
  • 20 (a)
OneToOne
Species with no ortholog for MED30:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MED30 Gene

ENSEMBL:
Gene Tree for MED30 (if available)
TreeFam:
Gene Tree for MED30 (if available)

Paralogs for MED30 Gene

No data available for Paralogs for MED30 Gene

Variants for MED30 Gene

Sequence variations from dbSNP and Humsavar for MED30 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs379187 -- 117,524,548(+) TCTCA(C/G)ATTAA intron-variant
rs402037 -- 117,520,843(+) GCTGT(C/G)TGGCC utr-variant-5-prime
rs405840 -- 117,528,460(+) AAACA(C/G)GTATG intron-variant
rs408478 -- 117,520,696(+) GGTGT(A/C)TATGA upstream-variant-2KB
rs411465 -- 117,528,619(+) TTACT(C/T)GATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED30 Gene

Variant ID Type Subtype PubMed ID
nsv831436 CNV Loss 17160897

Relevant External Links for MED30 Gene

HapMap Linkage Disequilibrium report
MED30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED30 Gene

Disorders for MED30 Gene

Relevant External Links for MED30

Genetic Association Database (GAD)
MED30
genes like me logo Genes that share disorders with MED30: view

No data available for UniProtKB/Swiss-Prot for MED30 Gene

Publications for MED30 Gene

  1. Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s. (PMID: 11909976) Baek H.J. … Roeder R.G. (Mol. Cell. Biol. 2002) 3 4
  2. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X. … Roeder R.G. (Mol. Cell 2005) 3 4
  5. Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. (PMID: 22446961) Lee Y.C. … Wu J.Y. (Nat. Genet. 2012) 3 48

Products for MED30 Gene

Sources for MED30 Gene

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