Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MED30 Gene

protein-coding   GIFtS: 53
GCID: GC08P118603

Mediator Complex Subunit 30

(Previous name: thyroid hormone receptor associated protein 6)
(Previous symbol: THRAP6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mediator Complex Subunit 301 2 3     TRAP/Mediator Complex Component TRAP252 3
THRAP61 2 3 5     MED30S2
TRAP252 3 5     Mediator Of RNA Polymerase II Transcription Subunit 302
Thyroid Hormone Receptor Associated Protein 61 2     Putative Mediator Of RNA Polymerase II Transcription Subunit 302
Thyroid Hormone Receptor-Associated Protein 62 3     Trap253
Thyroid Hormone Receptor-Associated Protein Complex 25 KDa Component2 3     

External Ids:    HGNC: 230321   Entrez Gene: 903902   Ensembl: ENSG000001647587   OMIM: 6102375   UniProtKB: Q96HR33   

Export aliases for MED30 gene to outside databases

Previous GC identifer: GC08P113859


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MED30 Gene:
The multiprotein TRAP/Mediator complex facilitates gene expression through a wide variety of transcriptional
activators. MED30 is a component of this complex that appears to be metazoan specific (Baek et al., 2002 (PubMed
11909976)).(supplied by OMIM, Nov 2010)

GeneCards Summary for MED30 Gene: 
MED30 (mediator complex subunit 30) is a protein-coding gene. Diseases associated with MED30 include thyroiditis, and conjunctivitis, and among its related super-pathways are Gene Expression and Axon guidance. GO annotations related to this gene include receptor activity and ligand-dependent nuclear receptor transcription coactivator activity.

UniProtKB/Swiss-Prot: MED30_HUMAN, Q96HR3
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED30 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MED30 gene promoter:
         HFH-3   TBP   AML1a   Olf-1   CUTL1   AREB6   POU2F1   POU2F1a   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED30 promoter sequence
   Search SABiosciences Chromatin IP Primers for MED30

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED30


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.11   Ensembl cytogenetic band:  8q24.11   HGNC cytogenetic band: 8q24.11

MED30 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED30 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P118603:  view genomic region     (about GC identifiers)

Start:
118,532,952 bp from pter      End:
118,552,501 bp from pter
Size:
19,550 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MED30_HUMAN, Q96HR3 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 30  
Size: 178 amino acids; 20277 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Subcellular location: Nucleus (Probable)

Explore the universe of human proteins at neXtProt for MED30: NX_Q96HR3

Explore proteomics data for MED30 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96HR3

  • MED30 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MED30 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001269915.1  NP_542382.1  

    ENSEMBL proteins: 
     ENSP00000297347   ENSP00000431051  
    Reactome Protein details: Q96HR3
    Human Recombinant Protein Products for MED30: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MED30
    OriGene Protein Over-expression Lysate for MED30
    OriGene MassSpec for MED30 
    OriGene Custom Protein Services for MED30
    GenScript Custom Purified and Recombinant Proteins Services for MED30
    Novus Biologicals MED30 Protein
    Novus Biologicals MED30 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MED30 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10235267
    GO:0005654nucleoplasm TAS--
    GO:0016592mediator complex IDA10198638

    MED30 for ontologies           About GeneDecksing



    MED30 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MED30
    GenScript Custom Superior Antibodies Services for MED30
    Novus Biologicals MED30 Antibodies
    Abcam antibodies for MED30
    Cloud-Clone Corp. Antibodies for MED30 
    Search ThermoFisher Antibodies for MED30
    LSBio Antibodies in human, mouse, rat for MED30 

    Assay Products for MED30: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED30
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED30
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED30 
    Cloud-Clone Corp. CLIAs for MED30


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR021019 Mediator_Med30_met

    Graphical View of Domain Structure for InterPro Entry Q96HR3

    ProtoNet protein and cluster: Q96HR3

    UniProtKB/Swiss-Prot: MED30_HUMAN, Q96HR3
    Similarity: Belongs to the Mediator complex subunit 30 family


    MED30 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED30_HUMAN, Q96HR3
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IDA10198638
    GO:0003712transcription cofactor activity IDA12218053
    GO:0004872receptor activity IDA12218053
    GO:0005515protein binding IPI--
    GO:0030374ligand-dependent nuclear receptor transcription coactivator activity NAS10235266
         
    MED30 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MED30:
     Decreased viability  Increased circadian period len  Synthetic lethal with c-Myc af 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Med30):
     cardiovascular system  cellular  growth/size  hematopoietic system  mortality/aging 
     muscle 

    MED30 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MED30 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MED30

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MED30 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MED30 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED30
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MED30
    SwitchGear 3'UTR luciferase reporter plasmidMED30 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MED30
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED30

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED30
    Sirion Biotech Customized adenovirus for overexpression of MED30

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MED30 (see all 8)
    OriGene ORF clones in mouse, rat for MED30
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED30 (NM_080651)
    Sino Biological Human cDNA Clone for MED30
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED30
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED30
    Sirion Biotech Customized lentivirus for stable overexpression of MED30 
                         Customized lentivirus expression plasmids for stable overexpression of MED30 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MED30
    Search LifeMap BioReagents cell lines for MED30
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED30


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MED30 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    2Axon guidance
    Developmental Biology0.69
    3Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes1.00
    4Transcriptional Regulation of White Adipocyte Differentiation
    Transcriptional Regulation of White Adipocyte Differentiation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MED30
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    1 GeneGo (Thomson Reuters) Pathway for MED30
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    4        Reactome Pathways for MED30
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation
    Generic Transcription Pathway
    Gene Expression



    MED30 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MED30

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/89 Interacting proteins for MED30 (Q96HR33 ENSP000002973474) via UniProtKB, MINT, STRING, and/or I2D (see all 89)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000227333Q96KQ73, ENSP000003973234I2D: score=1 STRING: ENSP00000397323
    EHMT2Q96KQ73I2D: score=1 
    ENSG00000206376Q96KQ73I2D: score=1 
    ENSG00000232045Q96KQ73I2D: score=1 
    ENSG00000236759Q96KQ73I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0019827stem cell maintenance IEA--
    GO:0030518intracellular steroid hormone receptor signaling pathway IDA11867769
    GO:0030521androgen receptor signaling pathway IDA12218053

    MED30 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MED30

    Search CenterWatch for drugs/clinical trials and news about MED30

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MED30 gene (2 alternative transcripts): 
    NM_001282986.1  NM_080651.3  

    Unigene Cluster for MED30:

    Mediator complex subunit 30
    Hs.492612  [show with all ESTs]
    Unigene Representative Sequence: BM458612
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297347(uc003yoj.3 uc011lib.2) ENST00000519879 ENST00000522839
    ENST00000519391
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED30
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MED30
    SwitchGear 3'UTR luciferase reporter plasmidMED30 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MED30
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED30
    Clone
    Products:
         
    OriGene clones in human, mouse for MED30 (see all 8)
    OriGene ORF clones in mouse, rat for MED30
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED30 (NM_080651)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED30
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED30
    Sirion Biotech Customized lentivirus for stable overexpression of MED30 
                         Customized lentivirus expression plasmids for stable overexpression of MED30 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MED30
    OriGene qSTAR qPCR primer pairs in human, mouse for MED30
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED30
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED30
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED30

    Additional mRNA sequence: 

    AY083305.1 BC008226.1 FM179284.1 

    4 DOTS entries:

    DT.220335  DT.86844569  DT.91697509  DT.91697498 

    24/67 AceView cDNA sequences (see all 67):

    AW439215 CB305552 AA573111 AW162597 AI767024 CF529815 AW103865 BM458612 
    AI656945 BE618444 CR602778 BX281284 AW614040 AI184166 AY083305 CN483837 
    AA810068 BI522539 BI757886 BX420298 BI757832 AW026676 BM972663 AA284743 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MED30 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTGAATAA
    MED30 Expression
    About this image


    See MED30 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MED30

    SOURCE GeneReport for Unigene cluster: Hs.492612

    UniProtKB/Swiss-Prot: MED30_HUMAN, Q96HR3
    Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle

        SABiosciences Custom PCR Arrays for MED30
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MED30
    OriGene qSTAR qPCR primer pairs in human, mouse for MED30
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED30
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED30
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED30
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED30

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MED30 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med301 , 5 mediator complex subunit 301, 5 90.07(n)1
    94.94(a)1
      15 (19.95 cM)5
    697901  NM_027212.21  NP_081488.11 
     527124455 
    chicken
    (Gallus gallus)
    Aves MED301 mediator complex subunit 30 80.79(n)
    88.7(a)
      420284  XM_418397.2  XP_418397.1 
    lizard
    (Anolis carolinensis)
    Reptilia MED306
    Uncharacterized protein
    88(a)
    1 ↔ 1
    4(6865287-6890521)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.290362 Xenopus laevis transcribed sequence with moderate similarity more 74.56(n)    48036292 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731132 hypothetical protein MGC73113 76.78(n)   393690  BC059478.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED301 Mediator complex subunit 30 55.56(n)
    41.67(a)
      38078  NM_138202.3  NP_612046.1 


    ENSEMBL Gene Tree for MED30 (if available)
    TreeFam Gene Tree for MED30 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MED30 gene
    1 SIMAP similar gene for MED30 using alignment to 1 protein entry:     MED30_HUMAN:
    MED30S

    MED30 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/428 SNPs in MED30 are shown (see all 428)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1140135651,2
    F--118531395(+) GTCCTC/AACACT 1 -- us2k11Minor allele frequency- A:0.12WA 118
    rs1442925921,2
    C--118531404(+) CTGAAC/TTTCTT 1 -- us2k10--------
    rs1911522881,2
    --118531448(+) CTTCAC/GGTGTT 1 -- us2k10--------
    rs625211981,2
    C--118531470(+) TCCTCG/ATCCTC 1 -- us2k14Minor allele frequency- A:0.14NA WA EA 360
    rs1830526281,2
    --118531585(+) TATCAG/TGAACT 1 -- us2k10--------
    rs1876118281,2
    --118531587(+) TCAGGA/GACTTT 1 -- us2k10--------
    rs726721261,2
    C,F--118531669(+) GTTTGT/GTCAGT 1 -- us2k13Minor allele frequency- G:0.06WA NA EA 358
    rs772356921,2
    F--118531676(+) CAGTAC/GGCTAT 1 -- us2k10--------
    rs1912786791,2
    C--118531708(+) CATAAC/TAGGTG 1 -- us2k10--------
    rs2003266641,2
    --118531917(+) TGAAC-/AGTAAG
            
    AGTAA
    1 -- cds10--------

    HapMap Linkage Disequilibrium report for MED30 (118532952 - 118552501 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MED30:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831436CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MED30
    DNA2.0 Custom Variant and Variant Library Synthesis for MED30

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610237    OMIM disorders: --

    6 diseases for MED30:    About MalaCards
    thyroiditis    conjunctivitis    kawasaki disease    mental retardation
    endotheliitis    neuronitis


    MED30 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MED30

    Export disorders for MED30 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MED30 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with MED30)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two new susceptibility loci for Kawasaki disease ident ified through genome-wide association analysis. (PubMed id 22446961)1, 4 Lee Y.C....Wu J.Y. (2012)
    2. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S....Conaway R.C. (2004)
    5. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PubMed id 12584197)1, 2 Sato S....Conaway J.W. (2003)
    6. Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s. (PubMed id 11909976)1, 2 Baek H.J.... Roeder R.G. (2002)
    7. The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13 L and regulates CDK8 module association with Mediator. (PubMed id 23322298)1 Davis M.A....Clurman B.E. (2013)
    8. Human mediator subunit MED26 functions as a docking s ite for transcription elongation factors. (PubMed id 21729782)1 Takahashi H....Conaway J.W. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90390 HGNC: 23032 AceView: THRAP6 Ensembl:ENSG00000164758 euGenes: HUgn90390
    ECgene: MED30 H-InvDB: MED30

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MED30 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MED30 gene:
    Search GeneIP for patents involving MED30

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MED30  
     OriGene qPCR primer pairs and template standards for MED30   OriGene Protein Over-expression Lysate for MED30  
     OriGene MassSpec something-or-other for MED30   OriGene clones in human, mouse for MED30  
     OriGene qSTAR qPCR primer pairs in human, mouse for MED30   OriGene Purified Protein for MED30  
     OriGene ORF clones in mouse, rat for MED30   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MED30   OriGene Custom Protein Services for MED30  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MED30
     QIAGEN SeqTarget long-range PCR primers for resequencing MED30
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED30
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED30
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED30
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED30
     GenScript Custom Purified and Recombinant Proteins Services for MED30 GenScript cDNA clones with any tag delivered in your preferred vector for MED30
     GenScript Custom Assay Services for MED30 GenScript Custom Superior Antibodies Services for MED30
     GenScript Custom overexpressing Cell Line Services for MED30 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MED30 promoter
     Search Chromatin IP Primers for MED30
     RT2 qPCR Primer Assay in human, mouse, rat MED30
     Search GNC Networks for MED30
     SABiosciences Custom PCR Arrays for MED30
     Search Tocris compounds for MED30
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for MED30
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MED30 antibodies
     MED30 proteins
     MED30 lysates
     Antibodies for MED30
     See all of Abcam's Antibodies, Kits and Proteins for MED30
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for MED30
     Antibodies for MED30
     ELISAs for MED30
     CLIAs for MED30
     Search LifeMap BioReagents cell lines for MED30
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED30
     SwitchGear 3'UTR luciferase reporter plasmids for MED30
     SwitchGear Promoter luciferase reporter plasmids for MED30
     Search ThermoFisher Antibodies for MED30
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED30
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MED30
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MED30
    Customized:
     lentivirus for stable overexpression of MED30
     lentivirus expression plasmids for stable overexpression of MED30
     adenovirus for overexpression of MED30
     LSBio Antibodies in human, mouse, rat for MED30
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MED30 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4