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Aliases for MED29 Gene

Aliases for MED29 Gene

  • Mediator Complex Subunit 29 2 3 4
  • IXL 3 4 6
  • Intersex-Like Protein 3 4
  • Mediator Of RNA Polymerase II Transcription Subunit 29 3
  • Intersex-Like (Drosophila) 2

External Ids for MED29 Gene

Previous HGNC Symbols for MED29 Gene

  • IXL

Previous GeneCards Identifiers for MED29 Gene

  • GC19P044577
  • GC19P039881
  • GC19P036328

Summaries for MED29 Gene

Entrez Gene Summary for MED29 Gene

  • MED29 is a subunit of the Mediator complex, a multiprotein coactivator of RNA transcription that interacts with DNA-bound transcriptional activators, RNA polymerase II (see MIM 180660), and general initiation factors (Sato et al., 2003 [PubMed 14576168]).[supplied by OMIM, Aug 2009]

GeneCards Summary for MED29 Gene

MED29 (Mediator Complex Subunit 29) is a Protein Coding gene. Among its related pathways are L1CAM interactions and Metabolism.

UniProtKB/Swiss-Prot for MED29 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED29 Gene

Genomics for MED29 Gene

Regulatory Elements for MED29 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MED29 Gene

Start:
39,391,303 bp from pter
End:
39,400,637 bp from pter
Size:
9,335 bases
Orientation:
Plus strand

Genomic View for MED29 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MED29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED29 Gene

Proteins for MED29 Gene

  • Protein details for MED29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX70-MED29_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 29
    Protein Accession:
    Q9NX70
    Secondary Accessions:
    • B4DNQ6
    • M0R2E4
    • Q5XX09
    • Q9NTF4

    Protein attributes for MED29 Gene

    Size:
    200 amino acids
    Molecular mass:
    21073 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Associates with the MED18/MED20 heteromer.
    SequenceCaution:
    • Sequence=AAU43732.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MED29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED29 Gene

Proteomics data for MED29 Gene at MOPED

Post-translational modifications for MED29 Gene

  • Ubiquitination at Lys76
  • Modification sites at PhosphoSitePlus

Other Protein References for MED29 Gene

No data available for DME Specific Peptides for MED29 Gene

Domains for MED29 Gene

Protein Domains for MED29 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED29 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NX70

UniProtKB/Swiss-Prot:

MED29_HUMAN :
  • Q9NX70
Family:
  • Belongs to the Mediator complex subunit 29 family.
genes like me logo Genes that share domains with MED29: view

No data available for Gene Families for MED29 Gene

Function for MED29 Gene

Molecular function for MED29 Gene

UniProtKB/Swiss-Prot Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14576168
genes like me logo Genes that share ontologies with MED29: view

Phenotypes for MED29 Gene

GenomeRNAi human phenotypes for MED29:
genes like me logo Genes that share phenotypes with MED29: view

Animal Model Products

CRISPR Products

miRNA for MED29 Gene

miRTarBase miRNAs that target MED29

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MED29

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MED29 Gene

Localization for MED29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED29 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED29 Gene COMPARTMENTS Subcellular localization image for MED29 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for MED29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0016592 mediator complex IDA 14638676
genes like me logo Genes that share ontologies with MED29: view

Pathways for MED29 Gene

genes like me logo Genes that share pathways with MED29: view

Gene Ontology (GO) - Biological Process for MED29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MED29: view

Transcripts for MED29 Gene

Unigene Clusters for MED29 Gene

Mediator complex subunit 29:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MED29

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MED29

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED29 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2:
SP3: - -

Relevant External Links for MED29 Gene

GeneLoc Exon Structure for
MED29
ECgene alternative splicing isoforms for
MED29

Expression for MED29 Gene

mRNA expression in normal human tissues for MED29 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MED29 Gene

SOURCE GeneReport for Unigene cluster for MED29 Gene Hs.611541

mRNA Expression by UniProt/SwissProt for MED29 Gene

Q9NX70-MED29_HUMAN
Tissue specificity: Widely expressed in embryo and adult.
genes like me logo Genes that share expressions with MED29: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MED29 Gene

Orthologs for MED29 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED29 35
  • 95.51 (n)
  • 93.75 (a)
MED29 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MED29 35
  • 90.17 (n)
  • 96 (a)
MED29 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED29 35
  • 91.96 (n)
  • 98.82 (a)
MED29 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med29 35
  • 85.87 (n)
  • 94.02 (a)
Med29 16
Med29 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MED29 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med29 35
  • 86.59 (n)
  • 95.11 (a)
lizard
(Anolis carolinensis)
Reptilia MED29 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24074 35
tropical clawed frog
(Silurana tropicalis)
Amphibia med29 35
  • 73.43 (n)
  • 80.42 (a)
Str.7460 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13786 35
zebrafish
(Danio rerio)
Actinopterygii dkfzp434h247 35
med29 35
  • 70.1 (n)
  • 72.06 (a)
med29 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ix 36
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2417 36
  • 32 (a)
OneToOne
Species with no ortholog for MED29:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MED29 Gene

ENSEMBL:
Gene Tree for MED29 (if available)
TreeFam:
Gene Tree for MED29 (if available)

Paralogs for MED29 Gene

Selected SIMAP similar genes for MED29 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MED29: view

No data available for Paralogs for MED29 Gene

Variants for MED29 Gene

Sequence variations from dbSNP and Humsavar for MED29 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs519575 -- 39,397,809(+) AGCAC(C/T)GCAGC utr-variant-3-prime
rs581933 -- 39,400,895(+) ctgcc(C/T)gcctc downstream-variant-500B
rs1057745 -- 39,397,750(+) GCAAA(C/G)GGAAT utr-variant-3-prime
rs1629174 -- 39,395,578(+) GTGCT(A/G)GAAGG intron-variant
rs1654627 -- 39,396,177(+) GGCTT(A/G)TGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED29 Gene

Variant ID Type Subtype PubMed ID
nsv911679 CNV Loss 21882294
nsv911680 CNV Loss 21882294
esv25791 CNV Gain 19812545
dgv3860n71 CNV Loss 21882294
dgv3861n71 CNV Loss 21882294
nsv911685 CNV Loss 21882294

Relevant External Links for MED29 Gene

HapMap Linkage Disequilibrium report
MED29
Human Gene Mutation Database (HGMD)
MED29

PCR Panel Products

  • Copy Number PCR Panels: for MED29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED29 Gene

Disorders for MED29 Gene

No disorders were found for MED29 Gene.

No data available for UniProtKB/Swiss-Prot for MED29 Gene

Publications for MED29 Gene

  1. IXL, a new subunit of the mammalian Mediator complex, functions as a transcriptional suppressor. (PMID: 15555573) Wang Y. … Wu X. (Biochem. Biophys. Res. Commun. 2004) 2 3 4
  2. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X. … Roeder R.G. (Mol. Cell 2005) 3 4
  3. A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. (PMID: 14576168) Sato S. … Conaway J.W. (J. Biol. Chem. 2003) 3 4
  4. A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. (PMID: 14638676) Tomomori-Sato C. … Conaway J.W. (J. Biol. Chem. 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for MED29 Gene

Sources for MED29 Gene

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