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MED29 Gene

protein-coding   GIFtS: 50
GCID: GC19P039881

Mediator Complex Subunit 29

(Previous name: intersex-like (Drosophila))
(Previous symbol: IXL)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mediator Complex Subunit 291 2 3
IXL1 2 3 5
Intersex-Like Protein2 3
Intersex-Like (Drosophila)1
Mediator Of RNA Polymerase II Transcription Subunit 292

External Ids:    HGNC: 230741   Entrez Gene: 555882   Ensembl: ENSG000000633227   OMIM: 6129145   UniProtKB: Q9NX703   

Export aliases for MED29 gene to outside databases

Previous GC identifers: GC19P044577 GC19P036328


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MED29 Gene:
MED29 is a subunit of the Mediator complex, a multiprotein coactivator of RNA transcription that interacts with
DNA-bound transcriptional activators, RNA polymerase II (see MIM 180660), and general initiation factors (Sato et
al., 2003 (PubMed 14576168)).(supplied by OMIM, Aug 2009)

GeneCards Summary for MED29 Gene:
MED29 (mediator complex subunit 29) is a protein-coding gene. Diseases associated with MED29 include coronary artery vasospasm, and pancreatic cancer.

UniProtKB/Swiss-Prot: MED29_HUMAN, Q9NX70
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MED29 gene promoter:
         c-Fos   p53   AP-1   ATF-2   CUTL1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED29 promoter sequence
   Search Chromatin IP Primers for MED29

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MED29


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

MED29 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED29 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P039881:  view genomic region     (about GC identifiers)

Start:
39,881,943 bp from pter      End:
39,891,277 bp from pter
Size:
9,335 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MED29_HUMAN, Q9NX70 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 29  
Size: 200 amino acids; 21073 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Associates with the
MED18/MED20 heteromer
Sequence caution: Sequence=AAU43732.1; Type=Erroneous initiation;
Secondary accessions: Q5XX09 Q9NTF4

Explore the universe of human proteins at neXtProt for MED29: NX_Q9NX70

Explore proteomics data for MED29 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys76
  • Modification sites at PhosphoSitePlus

  • See MED29 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060062.1  
    ENSEMBL proteins: 
     ENSP00000471101   ENSP00000314343   ENSP00000471444   ENSP00000472501   ENSP00000471802  
     ENSP00000473181  
    Reactome Protein details: Q9NX70

    MED29 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for MED29
    OriGene Protein Over-expression Lysate for MED29
    OriGene MassSpec for MED29
    OriGene Custom Protein Services for MED29
    GenScript Custom Purified and Recombinant Proteins Services for MED29
    Novus Biologicals MED29 Protein
    Novus Biologicals MED29 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MED29

    MED29 Antibody Products:

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    OriGene Custom Antibody Services for MED29
    Novus Biologicals MED29 Antibody
    Abcam antibodies for MED29
    Cloud-Clone Corp. Antibodies for MED29
    Search ThermoFisher Antibodies for MED29
    Search LSBio for Antibodies for MED29

    MED29 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED29
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED29
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED29
    Cloud-Clone Corp. CLIAs for MED29


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR021018 Mediator_Med29_met

    Graphical View of Domain Structure for InterPro Entry Q9NX70

    ProtoNet protein and cluster: Q9NX70

    UniProtKB/Swiss-Prot: MED29_HUMAN, Q9NX70
    Similarity: Belongs to the Mediator complex subunit 29 family


    MED29 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED29_HUMAN, Q9NX70
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14576168
         
    MED29 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MED29:
     Increased cell number in S and 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MED29
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MED29

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MED29
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MED29

    miRNA
    Products:
        
    miRTarBase miRNAs that target MED29:
    hsa-mir-935 (MIRT036688), hsa-mir-1296-5p (MIRT036114)

    Block miRNA regulation of human, mouse, rat MED29 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MED29 (see all 42):
    hsa-miR-3938 hsa-miR-25 hsa-miR-1258 hsa-miR-486-3p hsa-miR-4267 hsa-miR-637 hsa-miR-92b hsa-miR-615-5p
    SwitchGear 3'UTR luciferase reporter plasmidMED29 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MED29
    Predesigned siRNA for gene silencing in human, mouse, rat MED29

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED29

    Clone
    Products:
         
    OriGene clones in human, mouse for MED29 (see all 7)
    OriGene ORF clones in mouse, rat for MED29
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED29 (NM_017592)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED29
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED29

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MED29
    Browse ESI BIO Cell Lines and PureStem Progenitors for MED29 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED29


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MED29_HUMAN, Q9NX70: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0016592mediator complex IDA14638676

    MED29 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MED29 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3L1CAM interactions
    Developmental Biology0.63

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for MED29
        Transcriptional regulation of white adipocyte differentiation
    PPARA activates gene expression



    MED29 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MED29
    Interactions:

        Search GeneGlobe Interaction Network for MED29

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MED29 (Q9NX701, 2, 3 ENSP000003143434) via UniProtKB, MINT, STRING, and/or I2D (see all 182)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED20Q9H9441, 2, 3, ENSP000002653504EBI-394656,EBI-394644 MINT-50494 I2D: score=5 STRING: ENSP00000265350
    ENSG00000234258P349313, ENSP000003964864I2D: score=1 STRING: ENSP00000396486
    ENSG00000206383P349313I2D: score=1 
    ENSG00000236251P349313I2D: score=1 
    HSPA1LP349313I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    MED29 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MED29



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MED29 gene: 
    NM_017592.1  

    Unigene Cluster for MED29:

    Mediator complex subunit 29
    Hs.611541  [show with all ESTs]
    Unigene Representative Sequence: AY729650
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000599417 ENST00000315588(uc002olf.3 uc010xux.2) ENST00000600973
    ENST00000594368 ENST00000599213 ENST00000596297
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MED29 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MED29 (see all 42):
    hsa-miR-3938 hsa-miR-25 hsa-miR-1258 hsa-miR-486-3p hsa-miR-4267 hsa-miR-637 hsa-miR-92b hsa-miR-615-5p
    SwitchGear 3'UTR luciferase reporter plasmidMED29 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MED29
    Predesigned siRNA for gene silencing in human, mouse, rat MED29
    Clone
    Products:
         
    OriGene clones in human, mouse for MED29 (see all 7)
    OriGene ORF clones in mouse, rat for MED29
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED29 (NM_017592)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED29
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED29
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MED29
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED29
      QuantiTect SYBR Green Assays in human, mouse, rat MED29
      QuantiFast Probe-based Assays in human, mouse, rat MED29

    Additional mRNA sequence: 

    AK000411.1 AK026527.1 AK090877.1 AK092909.1 AK124629.1 AK294667.1 AK297772.1 AK298014.1 
    AK300563.1 AK316010.1 AL137304.1 AY729650.1 BC019015.2 

    9 DOTS entries:

    DT.305427  DT.100777756  DT.99941163  DT.97847858  DT.121415735  DT.121415809  DT.121415709  DT.121415796 
    DT.95353299 

    Selected AceView cDNA sequences (see all 176):

    BQ230527 BQ222830 BE904174 CF122892 BQ230800 CB156321 BE019523 BM759429 
    CK004154 AX747802 BE255704 BF974286 AK090877 AI720590 BQ686713 BM545191 
    BM757912 BM739838 BM760842 BU175996 BI490055 AI869275 BM548977 CF146555 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MED29    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:                          -                     
    SP2:                                                
    SP3:                    -     -                     


    ECgene alternative splicing isoforms for MED29

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MED29 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGTAACA
    MED29 Expression
    About this image

    MED29 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MED29 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.611541

    UniProtKB/Swiss-Prot: MED29_HUMAN, Q9NX70
    Tissue specificity: Widely expressed in embryo and adult

        Custom PCR Arrays for MED29
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat MED29
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED29

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MED29 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med291 , 5 mediator complex subunit 291, 5 85.87(n)1
    94.02(a)1
      7 (16.72 cM)5
    672241  NM_026042.31  NP_080318.21 
     283861465 
    lizard
    (Anolis carolinensis)
    Reptilia MED296
    mediator complex subunit 29
    74(a)
    1 ↔ 1
    AAWZ02039955(3072-7005)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.240742 Xenopus laevis transcribed sequence with moderate similarity more 74.57(n)    BJ094816.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dkfzp434h2472 hypothetical protein DKFZp434H247 homolog (human) 71.56(n)   286783  AF506210.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ix6
    intersex
    36(a)
    1 ↔ 1
    2R(7246942-7247668)


    ENSEMBL Gene Tree for MED29 (if available)
    TreeFam Gene Tree for MED29 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MED29 gene
    1 SIMAP similar gene for MED29 using alignment to 5 protein entries:     MED29_HUMAN (see all proteins):
    IXL

    MED29 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MED29 (see all 254)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20748521,2
    C,F,H--40029802(+) TTCGCA/GTGCTG 1 -- us2k125Minor allele frequency- T:0.00EA NA NS WA EU 9930
    rs104226341,2
    C,H--40029873(+) CCCACC/GTGAGC 1 -- us2k14Minor allele frequency- G:0.00NS EA 418
    rs1396483221,2
    C,F--40029924(+) GCTGGT/CGGGGG 1 -- us2k11Minor allele frequency- C:0.00NA 4544
    rs2007638091,2
    C--40029937(+) TGAATC/GTCCTC 1 -- us2k10--------
    rs1497453581,2
    C,F--40029948(+) TTCCAA/GAAGTT 1 -- us2k12Minor allele frequency- G:0.00NA EU 5827
    rs1884917961,2
    C--40029969(+) TGGATA/CTAGAA 1 -- us2k10--------
    rs2018577491,2
    --40030078(+) TTGGGA/GTCGAT 1 -- us2k10--------
    rs2012984911,2
    --40030086(+) GATGCA/GGTAGG 1 -- us2k10--------
    rs1919714051,2
    --40030436(+) CAACGA/GGACAA 1 -- us2k10--------
    rs1429157661,2
    C--40030621(+) GTGGGC/TCCCCG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MED29 (39881943 - 39891277 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MED29:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911685CNV Loss21882294
    nsv911680CNV Loss21882294
    nsv911679CNV Loss21882294
    dgv3860n71CNV Loss21882294
    dgv3861n71CNV Loss21882294
    esv25791CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing MED29:
    Pancreatic Cancer
    SeqTarget long-range PCR primers for resequencing MED29
    DNA2.0 Custom Variant and Variant Library Synthesis for MED29

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612914    OMIM disorders: --

    6 diseases for MED29:    About MalaCards
    coronary artery vasospasm    pancreatic cancer    pancreatitis    hypoxia
    malaria    melanoma


    MED29 for disorders           About GeneDecksing


    Export disorders for MED29 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MED29 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with MED29)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IXL, a new subunit of the mammalian Mediator complex, functions as a transcriptional suppressor. (PubMed id 15555573)1, 2, 3 Wang Y.... Wu X. (Biochem. Biophys. Res. Commun. 2004)
    2. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (Mol. Cell 2005)
    3. A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. (PubMed id 14638676)1, 2 Tomomori-Sato C....Conaway J.W. (J. Biol. Chem. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S.... Conaway R.C. (Mol. Cell 2004)
    6. A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. (PubMed id 14576168)1, 2 Sato S.... Conaway J.W. (J. Biol. Chem. 2003)
    7. Identification of the hypoxia-inducible factor 2I+ nuclear interactome in melanoma cells reveals master proteins involved in melanoma development. (PubMed id 23275444)1 Steunou A.L....Nieto L. (amp 2013)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. (PubMed id 23322298)1 Davis M.A....Clurman B.E. (amp 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55588 HGNC: 23074 AceView: IXL Ensembl:ENSG00000063322 euGenes: HUgn55588
    ECgene: MED29 H-InvDB: MED29

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MED29 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for MED29 gene:
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