Aliases for MED28 Gene
External Ids for MED28 Gene
Previous GeneCards Identifiers for MED28 Gene
GeneCards Summary for MED28 Gene
MED28 (Mediator Complex Subunit 28) is a Protein Coding gene. Diseases associated with MED28 include Chronic Intestinal Vascular Insufficiency and Cholinergic Urticaria. Among its related pathways are Developmental Biology and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include actin binding.
UniProtKB/Swiss-Prot for MED28 Gene
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways.