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MED28 Gene

protein-coding   GIFtS: 49
GCID: GC04P017616

Mediator Complex Subunit 28

(Previous names: mediator of RNA polymerase II transcription, subunit 28...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mediator Complex Subunit 281 2 3     Endothelial-Derived Gene 12
EG12 3 5     magicin2
Endothelial-Derived Protein 12 3     Mediator Of RNA Polymerase II Transcription Subunit 282
Merlin And Grb2-Interacting Cytoskeletal Protein2 3     Mediator Of RNA Polymerase II Transcription, Subunit 28 Homolog2
Tumor Angiogenesis Marker EG-12 3     Magicin3
Mediator Of RNA Polymerase II Transcription, Subunit 28 Homolog (S.
Cerevisiae)1
     MAGICIN5
1500003D12Rik2     

External Ids:    HGNC: 246281   Entrez Gene: 803062   Ensembl: ENSG000001185797   OMIM: 6103115   UniProtKB: Q9H2043   

Export aliases for MED28 gene to outside databases

Previous GC identifers: GC04P017293 GC04P016970


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MED28 Gene:
MED28 (mediator complex subunit 28) is a protein-coding gene. Diseases associated with MED28 include chronic intestinal vascular insufficiency, and endotheliitis. GO annotations related to this gene include actin binding.

UniProtKB/Swiss-Prot: MED28_HUMAN, Q9H204
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex
containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine
kinase signaling pathways

Gene Wiki entry for MED28 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MED28 gene promoter:
         USF1   p53   CUTL1   POU3F2   C/EBPalpha   E47   Max   USF-1   Ik-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED28 promoter sequence
   Search Chromatin IP Primers for MED28

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MED28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16   Ensembl cytogenetic band:  4p15.32   HGNC cytogenetic band: 4p16

MED28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED28 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P017616:  view genomic region     (about GC identifiers)

Start:
17,616,254 bp from pter      End:
17,635,728 bp from pter
Size:
19,475 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MED28_HUMAN, Q9H204 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 28  
Size: 178 amino acids; 19520 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Forms a ternary complex
with NF2/merlin and GRB2. Binds to actin
Sequence caution: Sequence=AAK11563.1; Type=Frameshift; Positions=165;
Secondary accessions: Q9BZJ5

Explore the universe of human proteins at neXtProt for MED28: NX_Q9H204

Explore proteomics data for MED28 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MED28 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079481.2  
    ENSEMBL proteins: 
     ENSP00000237380   ENSP00000426529  

    MED28 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MED28
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MED28
    GenScript Custom Purified and Recombinant Proteins Services for MED28
    Novus Biologicals MED28 Protein
    Novus Biologicals MED28 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MED28

    MED28 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MED28
    OriGene Custom Antibody Services for MED28
    Novus Biologicals MED28 Antibodies
    Abcam antibodies for MED28
    Cloud-Clone Corp. Antibodies for MED28
    ThermoFisher Antibodies for MED28
    LSBio Antibodies in human, mouse, rat for MED28

    MED28 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED28
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED28
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED28
    Cloud-Clone Corp. CLIAs for MED28


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR021640 Mediator_Med28

    Graphical View of Domain Structure for InterPro Entry Q9H204

    ProtoNet protein and cluster: Q9H204

    UniProtKB/Swiss-Prot: MED28_HUMAN, Q9H204
    Similarity: Belongs to the Mediator complex subunit 28 family


    MED28 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED28_HUMAN, Q9H204
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex
    containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine
    kinase signaling pathways
    Induction: Up-regulated by endothelial cells when exposed to tumor conditional media

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI10656681
         
    MED28 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for MED28:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased p24 protein expressi 
     Increased G1 DNA content 

         1 MGI phenotypic allele for Med28 (no phenotypes)

    MED28 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MED28
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MED28

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MED28
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MED28

    miRNA
    Products:
        
    miRTarBase miRNAs that target MED28:
    hsa-mir-744-5p (MIRT037505), hsa-mir-30d-5p (MIRT047827), hsa-mir-373-3p (MIRT002554), hsa-let-7b-5p (MIRT052202), hsa-mir-423-5p (MIRT038176)

    Block miRNA regulation of human, mouse, rat MED28 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MED28 (see all 16):
    hsa-miR-142-5p hsa-miR-3128 hsa-let-7d hsa-let-7c hsa-miR-340 hsa-miR-877* hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidMED28 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MED28
    Predesigned siRNA for gene silencing in human, mouse, rat MED28

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED28

    Clone
    Products:
         
    OriGene clones in human, mouse for MED28 (see all 7)
    OriGene ORF clones in mouse, rat for MED28
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED28 (NM_025205)
    Sino Biological Human cDNA Clone for MED28
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED28
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED28

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MED28
    Browse ESI BIO Cell Lines and PureStem Progenitors for MED28 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED28


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MED28_HUMAN, Q9H204: Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. Note=According to
    PubMed:15467741, it is cytoplasmic and mainly membrane-associated
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    cytosol2
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005856cytoskeleton ----
    GO:0016020membrane IEA--
    GO:0016592mediator complex IEA--
    GO:0030864cortical actin cytoskeleton IEA--

    MED28 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MED28
    Interactions:

        GeneGlobe Interaction Network for MED28

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MED28 (Q9H2041, 2, 3 ENSP000002373804) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062411, 2, 3, ENSP000003576564EBI-514199,EBI-515315 MINT-7041679 I2D: score=4 STRING: ENSP00000357656
    KLHL12Q53G592, 3, ENSP000003562304MINT-66369 I2D: score=5 STRING: ENSP00000356230
    LCKP062391, 3, ENSP000003378254EBI-514199,EBI-1348 I2D: score=2 STRING: ENSP00000337825
    ABL2P426842, 3, ENSP000003565954MINT-7041692 I2D: score=1 STRING: ENSP00000356595
    BTKQ061872, 3, ENSP000003081764MINT-7041634 I2D: score=1 STRING: ENSP00000308176
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0019827stem cell maintenance IEA--
    GO:0051151negative regulation of smooth muscle cell differentiation IEA--

    MED28 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MED28



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MED28 gene: 
    NM_025205.3  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000237380(uc003gpi.1) ENST00000506409 ENST00000503945(uc003gpj.3)
    ENST00000499786
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MED28 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MED28 (see all 16):
    hsa-miR-142-5p hsa-miR-3128 hsa-let-7d hsa-let-7c hsa-miR-340 hsa-miR-877* hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidMED28 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MED28
    Predesigned siRNA for gene silencing in human, mouse, rat MED28
    Clone
    Products:
         
    OriGene clones in human, mouse for MED28 (see all 7)
    OriGene ORF clones in mouse, rat for MED28
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED28 (NM_025205)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED28
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED28
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MED28
    OriGene qSTAR qPCR primer pairs in human, mouse for MED28
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED28
      QuantiTect SYBR Green Assays in human, mouse, rat MED28
      QuantiFast Probe-based Assays in human, mouse, rat MED28

    Selected AceView cDNA sequences (see all 242):

    BQ684834 BQ011812 CR605440 CR619532 BU073335 BU183150 CB160519 CR617018 
    BU855570 BQ015622 CR607989 BG141320 AA744505 CA426798 AI468531 BQ011981 
    BG480455 BQ575641 AI024136 BC011936 BU158756 AI743758 CA307193 BX357725 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MED28 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGTAGCTT
    MED28 Expression
    About this image

    MED28 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MED28 Protein Expression

    UniProtKB/Swiss-Prot: MED28_HUMAN, Q9H204
    Tissue specificity: Widely expressed. Highly expressed in vascular tissues such as placenta, testis and liver

        Custom PCR Arrays for MED28
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MED28
    OriGene qSTAR qPCR primer pairs in human, mouse for MED28
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED28
    QuantiTect SYBR Green Assays in human, mouse, rat MED28
    QuantiFast Probe-based Assays in human, mouse, rat MED28
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED28

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MED28 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med281 , 5 mediator of RNA polymerase II transcription, subunit more5
    mediator complex subunit 281
    87.83(n)1
    94.38(a)1
      5 (25.02 cM)5
    669991  NM_025895.41  NP_080171.11 
     455202215 
    chicken
    (Gallus gallus)
    Aves MED281 mediator complex subunit 28 70.83(n)
    80.68(a)
      425350  XM_003641248.2  XP_003641296.2 
    lizard
    (Anolis carolinensis)
    Reptilia MED286
    mediator complex subunit 28
    89(a)
    1 ↔ 1
    5(77086517-77087764)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.202302 Transcribed sequence with moderate similarity to protein more 78.31(n)    AL894521.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc74b112 Transcribed sequence with moderate similarity to protein more 81(n)    BQ074489.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED281 Mediator complex subunit 28 49.87(n)
    40.46(a)
      43079  NM_143140.1  NP_651397.1 


    ENSEMBL Gene Tree for MED28 (if available)
    TreeFam Gene Tree for MED28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MED28 gene

    MED28 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for MED28 (see all 8)
    PGOHUM00000238829 PGOHUM00000242434 PGOHUM00000246918 PGOHUM00000251067 PGOHUM00000247476


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MED28 (see all 372)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs45900221,2
    C,F,A,H--17614434(+) gATCCC/TTCGGT 1 -- int116Minor allele frequency- T:0.33NS EA NA WA CSA 730
    rs1850906631,2
    --17614625(+) TCTGTC/TTCCTT 1 -- int10--------
    rs46986301,2
    C,F,A,H--17614692(+) TGGAGG/CGCTCA 1 -- int116Minor allele frequency- C:0.31NS EA NA WA CSA 794
    rs730918291,2
    C,F--17614749(+) AGTTAT/CTTGGT 1 -- int12Minor allele frequency- C:0.06WA 120
    rs1476157321,2
    --17614755(+) TTGGTG/TTTAAA 1 -- int10--------
    rs1900740401,2
    --17614794(+) GCTCAC/GGCCTG 1 -- int10--------
    rs1811489021,2
    C--17614806(+) AATCCC/TAGCAC 1 -- int10--------
    rs46986311,2
    C,F,A,H--17614817(+) TTTGGG/AAGACC 1 -- int18Minor allele frequency- A:0.47NA WA CSA 17
    rs119435051,2
    C,H--17614828(+) gaggcA/Gggcgg 1 -- int10--------
    rs119348101,2
    C,F,H--17614869(+) ctgggC/Taacaa 1 -- int11Minor allele frequency- T:0.25NA 4

    HapMap Linkage Disequilibrium report for MED28 (17616254 - 17635728 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MED28: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MED28
    DNA2.0 Custom Variant and Variant Library Synthesis for MED28

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610311    OMIM disorders: --

    6 diseases for MED28:    
    About MalaCards
    chronic intestinal vascular insufficiency    endotheliitis    asthma    hiv-1
    malaria    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for MED28:
    Chronic intestinal vascular insufficiency     Asthma

    MED28 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MED28
    Human Genome Epidemiology (HuGE) Navigator: MED28 (1 document)

    Export disorders for MED28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MED28 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with MED28)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2. (PubMed id 15467741)1, 2, 3, 9 Wiederhold T.... Ramesh V. (Oncogene 2004)
    2. Identification of a novel endothelial-derived gene EG-1. (PubMed id 11779215)1, 2, 3, 9 Liu C.... Nguyen M.H. (Biochem. Biophys. Res. Commun. 2002)
    3. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (Mol. Cell 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S.... Conaway R.C. (Mol. Cell 2004)
    6. A systematic analysis of host factors reveals a Med23-interferon-I> regulatory axis against herpes simplex virus type 1 replication. (PubMed id 23950709)1 Griffiths S.J....Haas J. (PLoS Pathog. 2013)
    7. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    8. The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. (PubMed id 23322298)1 Davis M.A....Clurman B.E. (amp 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80306 HGNC: 24628 AceView: EG1 Ensembl:ENSG00000118579 euGenes: HUgn80306
    ECgene: MED28 H-InvDB: MED28

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MED28 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MED28 Genetics and Cytogenetics in Oncology and Haematology

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