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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MED27 Gene

protein-coding   GIFtS: 52
GCID: GC09M134735

Mediator Complex Subunit 27

(Previous names: cofactor required for Sp1 transcriptional activation, subunit...)
(Previous symbol: CRSP8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mediator Complex Subunit 271 2 3     CRSP Complex Subunit 82 3
CRSP81 2 3 5     CRAP342 5
Cofactor Required For Sp1 Transcriptional Activation, Subunit 8, 34kDa1 2     TRAP372
P37 TRAP/SMCC/PC2 Subunit2 3     Mediator Of RNA Polymerase II Transcription Subunit 272
Transcriptional Coactivator CRSP342 3     Cofactor Required For Sp1 Transcriptional Activation Subunit 83
CRSP342 3     

External Ids:    HGNC: 23771   Entrez Gene: 94422   Ensembl: ENSG000001605637   OMIM: 6050445   UniProtKB: Q6P2C83   

Export aliases for MED27 gene to outside databases

Previous GC identifers: GC09M133726 GC09M104229


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MED27 Gene:
The activation of gene transcription is a multistep process that is triggered by factors that recognize
transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation
by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required
for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein
is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which
interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and
cofactors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene,
and a pseudogene of this gene is located on the long arm of chromosome 5. (provided by RefSeq, Dec 2011)

GeneCards Summary for MED27 Gene: 
MED27 (mediator complex subunit 27) is a protein-coding gene. Diseases associated with MED27 include conjunctivitis, and thyroiditis, and among its related super-pathways are Gene Expression and Axon guidance. GO annotations related to this gene include transcription coactivator activity.

UniProtKB/Swiss-Prot: MED27_HUMAN, Q6P2C8
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED27 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_035014.4  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MED27 gene promoter:
         c-Fos   AP-1   SREBP-1c   Fra-1   FosB   SREBP-1b   SREBP-1a   Sox9   Cart-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED27 promoter sequence
   Search SABiosciences Chromatin IP Primers for MED27

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.13   Ensembl cytogenetic band:  9q34.13   HGNC cytogenetic band: 9q34.13

MED27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED27 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M134735:  view genomic region     (about GC identifiers)

Start:
134,735,494 bp from pter      End:
134,955,295 bp from pter
Size:
219,802 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MED27_HUMAN, Q6P2C8 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 27  
Size: 311 amino acids; 35432 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Subcellular location: Nucleus
Sequence caution: Sequence=AAH02878.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH02878.1; Type=Erroneous termination; Positions=109; Note=Translated as Gln; Sequence=CAH72530.1;
Type=Erroneous initiation; Sequence=CAH72547.1; Type=Erroneous initiation; Sequence=CAI13387.1; Type=Erroneous
initiation; Sequence=CAI17284.1; Type=Erroneous initiation;
Secondary accessions: O95401 Q4F964 Q5VTA4 Q5VTA5 Q9BU57 Q9NYR4
Alternative splicing: 2 isoforms:  Q6P2C8-1   Q6P2C8-2   

Explore the universe of human proteins at neXtProt for MED27: NX_Q6P2C8

Explore proteomics data for MED27 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6P2C8

  • MED27 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MED27 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001240810.1  NP_001240811.1  NP_004260.2  

    ENSEMBL proteins: 
     ENSP00000349530   ENSP00000292035   ENSP00000361258  
    Reactome Protein details: Q6P2C8
    Human Recombinant Protein Products for MED27: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MED27
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MED27
    GenScript Custom Purified and Recombinant Proteins Services for MED27
    Novus Biologicals MED27 Protein
    Novus Biologicals MED27 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MED27 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IDA9989412
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--

    MED27 for ontologies           About GeneDecksing



    MED27 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals MED27 Antibodies
    Abcam antibodies for MED27
    Cloud-Clone Corp. Antibodies for MED27 
    ThermoFisher Antibodies for MED27
    LSBio Antibodies in human, mouse, rat for MED27 

    Assay Products for MED27: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED27
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED27
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED27 
    Cloud-Clone Corp. CLIAs for MED27


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR021627 Mediator_Med27

    Graphical View of Domain Structure for InterPro Entry Q6P2C8

    ProtoNet protein and cluster: Q6P2C8

    UniProtKB/Swiss-Prot: MED27_HUMAN, Q6P2C8
    Similarity: Belongs to the Mediator complex subunit 27 family


    MED27 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED27_HUMAN, Q6P2C8
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA10882111
         
    MED27 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MED27 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MED27

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MED27 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MED27 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED27
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MED27:
    hsa-miR-3163 hsa-miR-137 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidMED27 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MED27
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED27

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of MED27

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MED27 (see all 7)
    OriGene ORF clones in mouse, rat for MED27
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED27 (NM_004269)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED27
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED27
    Sirion Biotech Customized lentivirus for stable overexpression of MED27 
                         Customized lentivirus expression plasmids for stable overexpression of MED27 

    Cell Line
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    Search LifeMap BioReagents cell lines for MED27
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED27


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MED27 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    2Axon guidance
    Developmental Biology0.69
    3Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes1.00
    4Transcriptional Regulation of White Adipocyte Differentiation
    Transcriptional Regulation of White Adipocyte Differentiation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MED27
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    1 GeneGo (Thomson Reuters) Pathway for MED27
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    4        Reactome Pathways for MED27
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation
    Generic Transcription Pathway
    Gene Expression



    MED27 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MED27

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/91 Interacting proteins for MED27 (Q6P2C81, 3 ENSP000002920354) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED22Q155281, 3, ENSP000003423434EBI-394603,EBI-394687 I2D: score=4 STRING: ENSP00000342343
    MED19A0JLT23, ENSP000003373404STRING: ENSP00000337340 I2D: score=4 
    MED30Q96HR33, ENSP000002973474I2D: score=3 STRING: ENSP00000297347
    MED10Q9BTT43, ENSP000002557644I2D: score=2 STRING: ENSP00000255764
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA9989412
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0019827stem cell maintenance IEA--

    MED27 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MED27

    Search CenterWatch for drugs/clinical trials and news about MED27

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MED27 gene (3 alternative transcripts): 
    NM_001253881.1  NM_001253882.1  NM_004269.3  

    Unigene Cluster for MED27:

    Mediator complex subunit 27
    Hs.374262  [show with all ESTs]
    Unigene Representative Sequence: AK124232
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357028 ENST00000292035(uc004cbe.2 uc004cbf.2 uc011mco.2 uc004cbg.4)
    ENST00000474263(uc022box.1) ENST00000372184
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED27
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MED27:
    hsa-miR-3163 hsa-miR-137 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidMED27 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MED27
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED27
    Clone
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    OriGene clones in human, mouse for MED27 (see all 7)
    OriGene ORF clones in mouse, rat for MED27
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED27 (NM_004269)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED27
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED27
    Sirion Biotech Customized lentivirus for stable overexpression of MED27 
                         Customized lentivirus expression plasmids for stable overexpression of MED27 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MED27
    OriGene qSTAR qPCR primer pairs in human, mouse for MED27
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED27
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED27
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED27

    Additional mRNA sequence: 

    AF104252.1 AF230382.1 AK124232.1 AK298436.1 AK316345.1 BC002878.1 BC064608.1 BC070331.1 
    DQ099387.1 Z36848.1 

    13 DOTS entries:

    DT.448359  DT.99978032  DT.120881522  DT.99972972  DT.100024427  DT.100000721  DT.100705001  DT.121203917 
    DT.100811924  DT.100811925  DT.120885781  DT.75195729  DT.95302465 

    24/208 AceView cDNA sequences (see all 208):

    BE743413 AA369831 CR617918 CA423130 BI223459 AA935357 NM_004269 CB140979 
    BQ669649 BQ017804 BX345115 AI650520 BM888163 BC064608 AL709138 BU070097 
    BX472624 AA584339 CR616414 CK820315 BQ614053 BC002878 CD515301 CB113047 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MED27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGGGTTCTT
    MED27 Expression
    About this image


    See MED27 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MED27

    SOURCE GeneReport for Unigene cluster: Hs.374262
        SABiosciences Custom PCR Arrays for MED27
    Primer
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    OriGene qPCR primer pairs and template standards for MED27
    OriGene qSTAR qPCR primer pairs in human, mouse for MED27
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED27
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED27
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED27
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED27

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MED27 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med271 , 5 mediator complex subunit 271, 5 88.21(n)1
    98.07(a)1
      2 (19.84 cM)5
    689751  NM_026896.41  NP_081172.21 
     293468195 
    chicken
    (Gallus gallus)
    Aves MED271 mediator complex subunit 27 84.31(n)
    94.81(a)
      417172  XM_415455.3  XP_415455.2 
    lizard
    (Anolis carolinensis)
    Reptilia MED276
    Uncharacterized protein
    87(a)
    1 ↔ 1
    GL343812.1(41531-127435)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.231482 Xenopus laevis transcribed sequence with strong similarity more 80.36(n)    BU913447.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc663022 hypothetical protein MGC66302 76.66(n)   393633  BC057508.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED271 Mediator complex subunit 27 50.74(n)
    39.86(a)
      40696  NM_141312.3  NP_649569.1 


    ENSEMBL Gene Tree for MED27 (if available)
    TreeFam Gene Tree for MED27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MED27 gene

    MED27 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MED27
    PGOHUM00000235292


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3814 SNPs in MED27 are shown (see all 3814)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1506389611,2
    --134735042(+) GGCCAC/TGTCTT 2 -- ds50010--------
    rs1918305531,2
    --134735069(+) GGCACC/TGAACA 2 -- ds50010--------
    rs1401025451,2
    --134735224(+) TGACTA/GGTTTA 2 -- ds50010--------
    rs559999611,2
    C,F--134735332(+) CCTCTC/TGCCCG 2 -- ds50013Minor allele frequency- T:0.20WA NA 240
    rs746280581,2
    C,F--134735394(+) GGGACG/ATGCTG 2 -- ds50013Minor allele frequency- A:0.04CSA WA EA 240
    rs22819981,2
    C,H--134735580(+) GACGAT/CACCCA 2 -- ut31 ese33Minor allele frequency- C:0.17NA WA 6
    rs2004841401,2
    C--134735938(+) GGCAGA/GTGTCA 4 T I mis10--------
    rs2014952901,2
    --134735987(+) GGGAAA/GGCCGT 4 L F mis10--------
    rs2012054011,2
    --134736103(+) TACGGC/GTGCTC 2 -- int10--------
    rs1132011301,2
    F--134736155(+) TTAAGC/TTGGCT 2 -- int12Minor allele frequency- T:0.50CSA 4

    HapMap Linkage Disequilibrium report for MED27 (134735494 - 134955295 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for MED27:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662096CNV Deletion23128226
    esv2659649CNV Deletion23128226
    esv2677413CNV Deletion23128226
    esv2481552CNV Deletion19546169
    nsv512994CNV Insertion21212237
    esv2619384CNV Insertion19546169
    nsv894012CNV Loss21882294
    nsv894013CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605044    OMIM disorders: --

    4 diseases for MED27:    About MalaCards
    conjunctivitis    thyroiditis    pancreatic cancer    pancreatitis


    MED27 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MED27

    Export disorders for MED27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MED27 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with MED27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. (PubMed id 9989412)1, 2, 3 Ryu S.... Tjian R. (1999)
    2. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S....Conaway R.C. (2004)
    6. The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs. (PubMed id 10882111)1, 2 Malik S.... Roeder R.G. (2000)
    7. Identification of the hypoxia-inducible factor 2a nucl ear interactome in melanoma cells reveals master proteins involved in melanoma d evelopment. (PubMed id 23275444)1 Steunou A.L....Nieto L. (2013)
    8. The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13 L and regulates CDK8 module association with Mediator. (PubMed id 23322298)1 Davis M.A....Clurman B.E. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9442 HGNC: 2377 AceView: CRSP8 Ensembl:ENSG00000160563 euGenes: HUgn9442
    ECgene: MED27 H-InvDB: MED27

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MED27 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MED27 gene:
    Search GeneIP for patents involving MED27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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