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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MED27 Gene

protein-coding   GIFtS: 52
GCID: GC09M134735

mediator complex subunit 27

(Previous names: cofactor required for Sp1 transcriptional activation, subunit...)
(Previous symbol: CRSP8)
 Explore 4 diseases affiliated with
MED27 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MED27    

Aliases
for MED27 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mediator Complex Subunit 271 2 3     Transcriptional Coactivator CRSP342 3
CRSP81 2 3 5     CRSP Complex Subunit 82 3
CRSP341 2 3     CRAP342 5
TRAP371 2     Mediator Of RNA Polymerase II Transcription Subunit 272
Cofactor Required For Sp1 Transcriptional Activation, Subunit 8, 34kDa1 2     Cofactor Required For Sp1 Transcriptional Activation Subunit 83
P37 TRAP/SMCC/PC2 Subunit2 3     

External Ids:    HGNC: 23771   Entrez Gene: 94422   Ensembl: ENSG000001605637   OMIM: 6050445   UniProtKB: Q6P2C83   

Export aliases for MED27 gene to outside databases

Previous GC identifers: GC09M133726 GC09M104229


Summaries
for MED27 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MED27:
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional
enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA
polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1
activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a
component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with
TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Alternatively
spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene
is located on the long arm of chromosome 5. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: MED27_HUMAN, Q6P2C8
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED27


Genomic Views
for MED27 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_035014.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MED27 gene promoter:
         c-Fos   AP-1   SREBP-1c   Fra-1   FosB   SREBP-1b   SREBP-1a   Sox9   Cart-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MED27 promoter sequence
   Search SABiosciences Chromatin IP Primers for MED27

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.13   Ensembl cytogenetic band:  9q34.13   HGNC cytogenetic band: 9q34.13

MED27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED27 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M134735:  view genomic region     (about GC identifiers)

Start:
 134,735,494 bp from pter      End:
 134,955,295 bp from pter
Size:
 219,802 bases      Orientation:
 minus strand

Proteins
for MED27 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MED27_HUMAN, Q6P2C8 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 27  
Size: 311 amino acids; 35432 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in
supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct
subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Subcellular location: Nucleus
Sequence caution: Sequence=AAH02878.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH02878.1; Type=Erroneous termination; Positions=109; Note=Translated as Gln; Sequence=CAH72530.1;
Type=Erroneous initiation; Sequence=CAH72547.1; Type=Erroneous initiation; Sequence=CAI13387.1; Type=Erroneous
initiation; Sequence=CAI17284.1; Type=Erroneous initiation;
Secondary accessions: O95401 Q4F964 Q5VTA4 Q5VTA5 Q9BU57 Q9NYR4
Alternative splicing: 2 isoforms:  Q6P2C8-1   Q6P2C8-2   

Explore the universe of human proteins at neXtProt for MED27: NX_Q6P2C8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6P2C8

    • MED27 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001240810.1  NP_001240811.1  NP_004260.2  

    ENSEMBL proteins: 
     ENSP00000292035   ENSP00000349530   ENSP00000361258  
    Reactome Protein details: Q6P2C8
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: MED27
    OriGene Custom Protein Services for MED27 
    GenScript Custom Purified and Recombinant Proteins Services for MED27
    Novus Biologicals MED27 Protein
    Novus Biologicals MED27 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MED27

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IDA9989412
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--


    MED27 for ontologies           About GeneDecksing



    MED27 Antibody Products: 
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    Abcam antibodies for MED27 
    Uscn Antibodies for MED27
    ThermoFisher Antibodies for MED27

    Assay Products for MED27: 
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    Uscn ELISAs and CLIAs for MED27

    Protein Domains /
    Families
    for MED27 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MED27 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR021627 Mediator_Med27

    Graphical View of Domain Structure for InterPro Entry Q6P2C8

    ProtoNet protein and cluster: Q6P2C8

    UniProtKB/Swiss-Prot: MED27_HUMAN, Q6P2C8
    Similarity: Belongs to the Mediator complex subunit 27 family


    Function
    for MED27 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MED27_HUMAN, Q6P2C8
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
    polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
    proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
    interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
    with RNA polymerase II and the general transcription factors

    miRNA
    Products:            		 OriGene 3'-UTR Clone: MED27
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED27
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MED27:
    hsa-miR-3163 hsa-miR-137 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmid: MED27 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED27 (see all 4)
    OriGene shRNA RFP: MED27
    OriGene siRNA: MED27
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED27

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MED27

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED27 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED27
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MED27 (NM_004269)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED27
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED27 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MED27
    Search LifeMap BioReagents cell lines for MED27

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED27

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA10882111


    MED27 for ontologies           About GeneDecksing



    Pathways & Interactions
    for MED27 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    		Generic Transcription Pathway1.00
    		Gene Expression0.46
    2HIV Infection
    		Transcription Ligand-Dependent Transcription of Retinoid-Target genes0.28
    		Transcription_Ligand-Dependent Transcription of Retinoid-Target genes0.28
    3Transcriptional Regulation of White Adipocyte Differentiation
    		Transcriptional Regulation of White Adipocyte Differentiation1.00
    4Axon guidance
    		Developmental Biology0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for MED27
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    1 GeneGo (Thomson Reuters) Pathway for MED27
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    4        Reactome Pathways for MED27
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation
    Generic Transcription Pathway
    Gene Expression



    MED27 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MED27

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/91 Interacting proteins for MED27 (Q6P2C81, 3 ENSP000002920354) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED22Q155281, 3, ENSP000003423434EBI-394603,EBI-394687 I2D: score=4 STRING: ENSP00000342343
    MED19A0JLT23, ENSP000003373404STRING: ENSP00000337340 I2D: score=4 
    MED30Q96HR33, ENSP000002973474I2D: score=3 STRING: ENSP00000297347
    MED10Q9BTT43, ENSP000002557644I2D: score=2 STRING: ENSP00000255764
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA9989412
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0019827stem cell maintenance IEA--


    MED27 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MED27 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MED27
    Search CenterWatch for drugs/clinical trials and news about MED27 

    Transcripts
    for MED27 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MED27 gene (3 alternative transcripts): 
    NM_001253881.1  NM_001253882.1  NM_004269.3  

    Unigene Cluster for MED27:

    Mediator complex subunit 27
    Hs.374262  [show with all ESTs]
    Unigene Representative Sequence: AK124232
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000292035(uc004cbe.2 uc004cbf.2 uc011mco.2 uc004cbg.4)
    ENST00000357028 ENST00000474263(uc022box.1) ENST00000372184

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MED27
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED27
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MED27:
    hsa-miR-3163 hsa-miR-137 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmid: MED27 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED27 (see all 4)
    OriGene shRNA RFP: MED27
    OriGene siRNA: MED27
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED27
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED27 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED27
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MED27 (NM_004269)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED27
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED27 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED27
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED27
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED27
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED27

    Additional cDNA sequence: 

    AF104252.1 AF230382.1 AK124232.1 AK298436.1 AK316345.1 BC002878.1 BC064608.1 BC070331.1 
    DQ099387.1 Z36848.1 

    13 DOTS entries:

    DT.448359  DT.99978032  DT.120881522  DT.99972972  DT.100024427  DT.100000721  DT.100705001  DT.121203917 
    DT.100811924  DT.100811925  DT.120885781  DT.75195729  DT.95302465 

    24/208 AceView cDNA sequences (see all 208):

    BQ549911 BM888163 BQ017804 AI650520 BX345115 BQ669649 BM555640 BX472624 
    NM_004269 BI223459 AA935357 CA442823 CB242837 CA423130 BU070097 BM975768 
    AL709138 CA437021 BI758223 AA777650 CB140979 BE743413 BC064608 AA369831 

    GeneLoc Exon Structure


    Expression
    for MED27 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MED27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGGGGTTCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MED27 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    ES04(HES-4) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MED27 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MED27

    SOURCE GeneReport for Unigene cluster: Hs.374262
        SABiosciences Custom PCR Arrays for MED27
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED27
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED27
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED27
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED27
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED27

    Orthologs
    for MED27 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MED27 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Med271 , 5 mediator complex subunit 271, 5 88.21(n)1
    98.07(a)1    		   2 (19.84 cM)5
    689751  NM_026896.41  NP_081172.21 
     293468195 
    chicken
    (Gallus gallus)    		 Aves MED271 mediator complex subunit 27 84.31(n)
    94.81(a)    		   417172  XM_415455.3  XP_415455.2 
    lizard
    (Anolis carolinensis)    		 Reptilia MED276
    		 --
    		 87(a)
    		 1 ↔ 1
    		 GL343812.1(41533-127435)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.231482 Xenopus laevis transcribed sequence with strong similarity more 80.36(n)    BU913447.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc663022 hypothetical protein MGC66302 76.66(n)   393633  BC057508.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta MED271 Mediator complex subunit 27 50.74(n)
    39.86(a)    		   40696  NM_141312.3  NP_649569.1 


    ENSEMBL Gene Tree for MED27 (if available)
    TreeFam Gene Tree for MED27 (if available) 

    Paralogs
    for MED27 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MED27 gene

    MED27 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MED27
    PGOHUM00000235292


    Genomic Variants
    for MED27 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3249 NCBI SNPs in MED27 are shown (see all 3249)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1506389611,2
    		--134735042(+) GGCCAC/TGTCTT 2 -- ds50010--------
    rs1918305531,2
    		--134735069(+) GGCACC/TGAACA 2 -- ds50010--------
    rs1401025451,2
    		--134735224(+) TGACTA/GGTTTA 2 -- ds50010--------
    rs559999611,2
    		C,--134735332(+) CCTCTC/TGCCCG 2 -- ds50013Minor allele frequency- T:0.20WA NA 240
    rs746280581,2
    		--134735394(+) GGGACG/ATGCTG 2 -- ds50013Minor allele frequency- A:0.04CSA WA EA 240
    rs22819981,2
    		C,H,--134735580(+) GACGAT/CACCCA 2 -- ut31 ese33Minor allele frequency- C:0.17NA WA 6
    rs2014952901,2
    		--134735987(+) GGGAAA/GGCCGT 4 L F mis10--------
    rs2012054011,2
    		--134736103(+) TACGGC/GTGCTC 2 -- int10--------
    rs1132011301,2
    		F--134736155(+) TTAAGC/TTGGCT 2 -- int12Minor allele frequency- T:0.50CSA 4
    rs1399269531,2
    		--134736205(+) CAGGCA/GGAACC 2 -- int10--------

    HapMap Linkage Disequilibrium report for MED27 (134735494 - 134955295 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MED27
         1 Indel: 100793

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    Disorders / Diseases
    for MED27 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MED27 for disorders           About GeneDecksing

    OMIM gene information: 605044    OMIM disorders: --

    4 diseases for MED27:    About MalaCards
    conjunctivitis    thyroiditis    pancreatic cancer    pancreatitis


    Export disorders for MED27 gene to outside databases

    Publications
    for MED27 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MED27 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with MED27)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. (PubMed id 9989412)1, 2, 3 Ryu S.... Tjian R. (1999)
    2. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S....Conaway R.C. (2004)
    6. The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs. (PubMed id 10882111)1, 2 Malik S.... Roeder R.G. (2000)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    External Searches for MED27 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MED27 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9442 HGNC: 2377 AceView: CRSP8 Ensembl:ENSG00000160563 euGenes: HUgn9442
    ECgene: MED27 H-InvDB: MED27

    Other Databases showing MED27 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MED27 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MED27 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MED27 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MED27 gene:
    Search GeneIP for patents involving MED27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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