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Aliases for MED27 Gene

Aliases for MED27 Gene

  • Mediator Complex Subunit 27 2 3 4
  • CRSP8 3 4 6
  • Cofactor Required For Sp1 Transcriptional Activation, Subunit 8, 34kDa 2 3
  • Transcriptional Coactivator CRSP34 3 4
  • P37 TRAP/SMCC/PC2 Subunit 3 4
  • CRSP Complex Subunit 8 3 4
  • CRAP34 3 6
  • CRSP34 3 4
  • Cofactor Required For Sp1 Transcriptional Activation Subunit 8 4
  • Mediator Of RNA Polymerase II Transcription Subunit 27 3
  • TRAP37 3

External Ids for MED27 Gene

Previous Symbols for MED27 Gene

  • CRSP8

Summaries for MED27 Gene

Entrez Gene Summary for MED27 Gene

  • The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

GeneCards Summary for MED27 Gene

MED27 (Mediator Complex Subunit 27) is a Protein Coding gene. Among its related pathways are L1CAM interactions and Metabolism. GO annotations related to this gene include transcription coactivator activity.

UniProtKB/Swiss-Prot for MED27 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED27 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED27 Gene

Genomics for MED27 Gene

Genomic Location for MED27 Gene

Start:
131,860,107 bp from pter
End:
132,079,908 bp from pter
Size:
219,802 bases
Orientation:
Minus strand

Genomic View for MED27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MED27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED27 Gene

Regulatory Elements for MED27 Gene

Proteins for MED27 Gene

  • Protein details for MED27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P2C8-MED27_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 27
    Protein Accession:
    Q6P2C8
    Secondary Accessions:
    • O95401
    • Q4F964
    • Q5VTA4
    • Q5VTA5
    • Q9BU57
    • Q9NYR4
    • V9GYV9

    Protein attributes for MED27 Gene

    Size:
    311 amino acids
    Molecular mass:
    35432 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
    SequenceCaution:
    • Sequence=AAH02878.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH02878.1; Type=Erroneous termination; Positions=109; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for MED27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED27 Gene

Proteomics data for MED27 Gene at MOPED

Post-translational modifications for MED27 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys50, Lys112, Lys116, Lys134, Lys145, Lys233, and Lys275

Other Protein References for MED27 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MED27 Gene

Domains for MED27 Gene

Protein Domains for MED27 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MED27_HUMAN
Family:
  • Belongs to the Mediator complex subunit 27 family.:
    • Q6P2C8
genes like me logo Genes that share domains with MED27: view

No data available for Gene Families for MED27 Gene

Function for MED27 Gene

Molecular function for MED27 Gene

UniProtKB/Swiss-Prot Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 10882111
GO:0005515 protein binding IPI 12584197
genes like me logo Genes that share ontologies with MED27: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MED27 Gene

Localization for MED27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED27 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED27 Gene COMPARTMENTS Subcellular localization image for MED27 gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MED27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IDA 9989412
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MED27: view

Pathways for MED27 Gene

genes like me logo Genes that share pathways with MED27: view

Pathways by source for MED27 Gene

Gene Ontology (GO) - Biological Process for MED27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 9989412
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
GO:0019827 stem cell maintenance IEA --
genes like me logo Genes that share ontologies with MED27: view

Transcripts for MED27 Gene

Unigene Clusters for MED27 Gene

Mediator complex subunit 27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MED27 Gene

No ASD Table

Relevant External Links for MED27 Gene

GeneLoc Exon Structure for
MED27
ECgene alternative splicing isoforms for
MED27

Expression for MED27 Gene

mRNA expression in normal human tissues for MED27 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED27 Gene

SOURCE GeneReport for Unigene cluster for MED27 Gene Hs.374262

genes like me logo Genes that share expressions with MED27: view

Orthologs for MED27 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED27 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MED27 36
  • 91.1 (n)
  • 98.39 (a)
MED27 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED27 36
  • 94.53 (n)
  • 98.07 (a)
MED27 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med27 36
  • 88.21 (n)
  • 98.07 (a)
Med27 16
Med27 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MED27 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MED27 37
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med27 36
  • 88.1 (n)
  • 98.07 (a)
chicken
(Gallus gallus)
Aves MED27 36
  • 84.31 (n)
  • 94.81 (a)
MED27 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MED27 37
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23148 36
tropical clawed frog
(Silurana tropicalis)
Amphibia med27 36
  • 80.49 (n)
  • 92.28 (a)
Str.899 36
zebrafish
(Danio rerio)
Actinopterygii med27 36
  • 75.78 (n)
  • 88.42 (a)
med27 37
  • 88 (a)
OneToOne
zgc66302 36
African malaria mosquito
(Anopheles gambiae)
Insecta MED27_ANOGA 36
  • 50.4 (n)
  • 43.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta MED27 36
  • 50.74 (n)
  • 39.86 (a)
MED27 37
  • 39 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToOne
Species with no ortholog for MED27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MED27 Gene

ENSEMBL:
Gene Tree for MED27 (if available)
TreeFam:
Gene Tree for MED27 (if available)

Paralogs for MED27 Gene

Pseudogenes.org Pseudogenes for MED27 Gene

genes like me logo Genes that share paralogs with MED27: view

No data available for Paralogs for MED27 Gene

Variants for MED27 Gene

Sequence variations from dbSNP and Humsavar for MED27 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs913509 -- 131,862,364(+) CTGGC(A/G)TGAGA intron-variant
rs2281998 -- 131,860,193(+) GACGA(C/T)ACCCA utr-variant-3-prime
rs2987405 -- 131,862,715(+) ACGAT(C/T)TGTTA intron-variant
rs3802352 -- 131,863,315(+) CAGAG(C/G)GGGAG intron-variant
rs3802353 -- 131,863,388(+) AGCAA(C/T)GGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED27 Gene

Variant ID Type Subtype PubMed ID
nsv894012 CNV Loss 21882294
esv2677413 CNV Deletion 23128226
esv2659649 CNV Deletion 23128226
nsv512994 CNV Insertion 21212237
esv2619384 CNV Insertion 19546169
nsv894013 CNV Gain 21882294
esv2481552 CNV Deletion 19546169
esv2662096 CNV Deletion 23128226

Relevant External Links for MED27 Gene

HapMap Linkage Disequilibrium report
MED27

Disorders for MED27 Gene

Relevant External Links for MED27

Genetic Association Database (GAD)
MED27
genes like me logo Genes that share disorders with MED27: view

No data available for UniProtKB/Swiss-Prot for MED27 Gene

Publications for MED27 Gene

  1. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. (PMID: 9989412) Ryu S. … Tjian R. (Nature 1999) 2 3 4
  2. The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs. (PMID: 10882111) Malik S. … Roeder R.G. (Mol. Cell 2000) 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MED27 Gene

  • Addgene plasmids for MED27

Sources for MED27 Gene

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