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Aliases for MED26 Gene

Aliases for MED26 Gene

  • Mediator Complex Subunit 26 2 3 4
  • CRSP7 3 4 6
  • Cofactor Required For Sp1 Transcriptional Activation, Subunit 7, 70kDa 2 3
  • Cofactor Required For Sp1 Transcriptional Activation Subunit 7 3 4
  • Activator-Recruited Cofactor 70 KDa Component 3 4
  • Transcriptional Coactivator CRSP70 3 4
  • CRSP Complex Subunit 7 3 4
  • CRSP70 3 6
  • ARC70 3 4
  • Cofactor Required For Sp1 Transcriptional Activation, Subunit 7 (70kD) 3
  • Mediator Of RNA Polymerase II Transcription Subunit 26 3

External Ids for MED26 Gene

Previous Symbols for MED26 Gene

  • CRSP7

Summaries for MED26 Gene

Entrez Gene Summary for MED26 Gene

  • The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]

GeneCards Summary for MED26 Gene

MED26 (Mediator Complex Subunit 26) is a Protein Coding gene. Among its related pathways are L1CAM interactions and Metabolism. GO annotations related to this gene include transcription coactivator activity and RNA polymerase II transcription cofactor activity. An important paralog of this gene is ENSG00000141979.

UniProtKB/Swiss-Prot for MED26 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED26 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED26 Gene

Genomics for MED26 Gene

Genomic Location for MED26 Gene

Start:
16,574,907 bp from pter
End:
16,629,062 bp from pter
Size:
54,156 bases
Orientation:
Minus strand

Genomic View for MED26 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MED26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED26 Gene

Regulatory Elements for MED26 Gene

Proteins for MED26 Gene

  • Protein details for MED26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95402-MED26_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 26
    Protein Accession:
    O95402
    Secondary Accessions:
    • A1A4S3
    • Q0VGB6

    Protein attributes for MED26 Gene

    Size:
    600 amino acids
    Molecular mass:
    65446 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

    Alternative splice isoforms for MED26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED26 Gene

Proteomics data for MED26 Gene at MOPED

Post-translational modifications for MED26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MED26 Gene

No data available for DME Specific Peptides for MED26 Gene

Domains for MED26 Gene

Protein Domains for MED26 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MED26_HUMAN
Domain:
  • Contains 1 TFIIS N-terminal domain.:
    • O95402
Family:
  • Belongs to the Mediator complex subunit 26 family.:
    • O95402
genes like me logo Genes that share domains with MED26: view

No data available for Gene Families for MED26 Gene

Function for MED26 Gene

Molecular function for MED26 Gene

UniProtKB/Swiss-Prot Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

Gene Ontology (GO) - Molecular Function for MED26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IDA 15989967
GO:0003677 DNA binding IEA --
GO:0003713 transcription coactivator activity TAS 9989412
GO:0005515 protein binding IPI 15175163
genes like me logo Genes that share ontologies with MED26: view
genes like me logo Genes that share phenotypes with MED26: view

miRNA for MED26 Gene

miRTarBase miRNAs that target MED26

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MED26 Gene

Localization for MED26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED26 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED26 Gene COMPARTMENTS Subcellular localization image for MED26 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MED26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0016592 mediator complex IDA 15989967
genes like me logo Genes that share ontologies with MED26: view

Pathways for MED26 Gene

genes like me logo Genes that share pathways with MED26: view

Gene Ontology (GO) - Biological Process for MED26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 15989967
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with MED26: view

Transcripts for MED26 Gene

Unigene Clusters for MED26 Gene

Mediator complex subunit 26:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MED26 Gene

No ASD Table

Relevant External Links for MED26 Gene

GeneLoc Exon Structure for
MED26
ECgene alternative splicing isoforms for
MED26

Expression for MED26 Gene

mRNA expression in normal human tissues for MED26 Gene

mRNA differential expression in normal tissues according to GTEx for MED26 Gene

This gene is overexpressed in Testis (12.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED26 Gene

SOURCE GeneReport for Unigene cluster for MED26 Gene Hs.715040

genes like me logo Genes that share expressions with MED26: view

Orthologs for MED26 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 97 (a)
OneToMany
MED26 36
  • 95.44 (n)
  • 94.76 (a)
cow
(Bos Taurus)
Mammalia MED26 36
  • 89.82 (n)
  • 91.65 (a)
MED26 37
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 92 (a)
OneToMany
MED26 36
  • 90.71 (n)
  • 92.49 (a)
mouse
(Mus musculus)
Mammalia Med26 36
  • 83.79 (n)
  • 86.39 (a)
Med26 16
Med26 37
  • 86 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 69 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Med26 36
  • 85.03 (n)
  • 87.24 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 65 (a)
OneToMany
MED26 36
  • 67.54 (n)
  • 70.53 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 55 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.12095 36
tropical clawed frog
(Silurana tropicalis)
Amphibia med26 36
  • 62.23 (n)
  • 63.56 (a)
Str.1314 36
zebrafish
(Danio rerio)
Actinopterygii crsp7 36
  • 60.17 (n)
  • 57.41 (a)
Dr.11494 36
MED26 37
  • 25 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta MED26 37
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 25 (a)
OneToMany
Species with no ortholog for MED26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MED26 Gene

ENSEMBL:
Gene Tree for MED26 (if available)
TreeFam:
Gene Tree for MED26 (if available)

Paralogs for MED26 Gene

Paralogs for MED26 Gene

Selected SIMAP similar genes for MED26 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MED26: view

Variants for MED26 Gene

Sequence variations from dbSNP and Humsavar for MED26 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs190386 -- 16,596,174(-) GCATG(G/T)ctggg intron-variant
rs747191 -- 16,588,529(+) GGACC(A/G)CACCT intron-variant
rs751788 -- 16,606,034(+) GGATA(C/G)AGCAT intron-variant
rs754291 -- 16,589,240(-) CTCTT(C/T)CTTGG intron-variant
rs754292 -- 16,589,002(-) TGGCT(A/G)TCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED26 Gene

Variant ID Type Subtype PubMed ID
nsv911167 CNV Loss 21882294
nsv510757 CNV Loss 20534489
esv2718266 CNV Deletion 23290073
esv2674048 CNV Deletion 23128226

Relevant External Links for MED26 Gene

HapMap Linkage Disequilibrium report
MED26

Disorders for MED26 Gene

No disorders were found for MED26 Gene.

No data available for UniProtKB/Swiss-Prot for MED26 Gene

Publications for MED26 Gene

  1. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. (PMID: 9989412) Ryu S. … Tjian R. (Nature 1999) 2 3 4
  2. Composite co-activator ARC mediates chromatin-directed transcriptional activation. (PMID: 10235267) Naeaer A.M. … Tjian R. (Nature 1999) 3 4
  3. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 3 4
  4. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X. … Roeder R.G. (Mol. Cell 2005) 3 4
  5. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D. … Shiekhattar R. (Cell 2005) 3

Products for MED26 Gene

Sources for MED26 Gene

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