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Aliases for MED26 Gene

Aliases for MED26 Gene

  • Mediator Complex Subunit 26 2 3 4 5
  • Cofactor Required For Sp1 Transcriptional Activation, Subunit 7, 70kDa 2 3
  • Cofactor Required For Sp1 Transcriptional Activation Subunit 7 3 4
  • Activator-Recruited Cofactor 70 KDa Component 3 4
  • Transcriptional Coactivator CRSP70 3 4
  • CRSP Complex Subunit 7 3 4
  • CRSP7 3 4
  • ARC70 3 4
  • Cofactor Required For Sp1 Transcriptional Activation, Subunit 7 (70kD) 3
  • CRSP70 3

External Ids for MED26 Gene

Previous HGNC Symbols for MED26 Gene

  • CRSP7

Previous GeneCards Identifiers for MED26 Gene

  • GC19M016546
  • GC19M016685
  • GC19M016254

Summaries for MED26 Gene

Entrez Gene Summary for MED26 Gene

  • The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]

GeneCards Summary for MED26 Gene

MED26 (Mediator Complex Subunit 26) is a Protein Coding gene. Among its related pathways are Gene Expression and Developmental Biology. GO annotations related to this gene include transcription coactivator activity and RNA polymerase II transcription cofactor activity. An important paralog of this gene is ENSG00000141979.

UniProtKB/Swiss-Prot for MED26 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED26 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED26 Gene

Genomics for MED26 Gene

Regulatory Elements for MED26 Gene

Enhancers for MED26 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MED26 on UCSC Golden Path with GeneCards custom track

Promoters for MED26 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MED26 on UCSC Golden Path with GeneCards custom track

Genomic Location for MED26 Gene

Chromosome:
19
Start:
16,574,907 bp from pter
End:
16,629,062 bp from pter
Size:
54,156 bases
Orientation:
Minus strand

Genomic View for MED26 Gene

Genes around MED26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED26 Gene

Proteins for MED26 Gene

  • Protein details for MED26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95402-MED26_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 26
    Protein Accession:
    O95402
    Secondary Accessions:
    • A1A4S3
    • Q0VGB6

    Protein attributes for MED26 Gene

    Size:
    600 amino acids
    Molecular mass:
    65446 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CEBPB (when not methylated)(PubMed:20111005).

    Alternative splice isoforms for MED26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED26 Gene

Proteomics data for MED26 Gene at MOPED

Post-translational modifications for MED26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MED26 Gene

No data available for DME Specific Peptides for MED26 Gene

Domains & Families for MED26 Gene

Gene Families for MED26 Gene

Protein Domains for MED26 Gene

Suggested Antigen Peptide Sequences for MED26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95402

UniProtKB/Swiss-Prot:

MED26_HUMAN :
  • Contains 1 TFIIS N-terminal domain.
  • Belongs to the Mediator complex subunit 26 family.
Domain:
  • Contains 1 TFIIS N-terminal domain.
Family:
  • Belongs to the Mediator complex subunit 26 family.
genes like me logo Genes that share domains with MED26: view

Function for MED26 Gene

Molecular function for MED26 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
genes like me logo Genes that share phenotypes with MED26: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED26 Gene

Localization for MED26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED26 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED26 Gene COMPARTMENTS Subcellular localization image for MED26 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for MED26 Gene

Pathways & Interactions for MED26 Gene

genes like me logo Genes that share pathways with MED26: view

Pathways by source for MED26 Gene

Gene Ontology (GO) - Biological Process for MED26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with MED26: view

No data available for SIGNOR curated interactions for MED26 Gene

Drugs & Compounds for MED26 Gene

No Compound Related Data Available

Transcripts for MED26 Gene

Unigene Clusters for MED26 Gene

Mediator complex subunit 26:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MED26 Gene

No ASD Table

Relevant External Links for MED26 Gene

GeneLoc Exon Structure for
MED26
ECgene alternative splicing isoforms for
MED26

Expression for MED26 Gene

mRNA expression in normal human tissues for MED26 Gene

mRNA differential expression in normal tissues according to GTEx for MED26 Gene

This gene is overexpressed in Testis (x12.1).

Protein differential expression in normal tissues from HIPED for MED26 Gene

This gene is overexpressed in Heart (42.1) and Pancreatic juice (19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED26 Gene



SOURCE GeneReport for Unigene cluster for MED26 Gene Hs.715040

genes like me logo Genes that share expression patterns with MED26: view

Protein tissue co-expression partners for MED26 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MED26 Gene

Orthologs for MED26 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED26 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MED26 35
  • 89.82 (n)
  • 91.65 (a)
MED26 36
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MED26 35
  • 90.71 (n)
  • 92.49 (a)
-- 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Med26 35
  • 83.79 (n)
  • 86.39 (a)
Med26 16
Med26 36
  • 86 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia MED26 35
  • 95.44 (n)
  • 94.76 (a)
-- 36
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Med26 35
  • 85.03 (n)
  • 87.24 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves MED26 35
  • 67.54 (n)
  • 70.53 (a)
-- 36
  • 65 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia med26 35
  • 62.23 (n)
  • 63.56 (a)
Str.1314 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.12095 35
zebrafish
(Danio rerio)
Actinopterygii crsp7 35
  • 60.17 (n)
  • 57.41 (a)
Dr.11494 35
MED26 36
  • 25 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta MED26 36
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for MED26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MED26 Gene

ENSEMBL:
Gene Tree for MED26 (if available)
TreeFam:
Gene Tree for MED26 (if available)

Paralogs for MED26 Gene

Paralogs for MED26 Gene

(2) SIMAP similar genes for MED26 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MED26: view

Variants for MED26 Gene

Sequence variations from dbSNP and Humsavar for MED26 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7259072 -- 16,594,896(+) AAAAC(A/G)GCTCT intron-variant
rs12977770 -- 16,601,282(+) tcccg(A/T)gtagc intron-variant
rs8102254 -- 16,618,732(+) CCTGG(A/G)AACAT intron-variant
rs8103548 -- 16,604,155(+) ACCCA(C/T)GTGTA intron-variant
rs8104186 -- 16,606,420(+) ggtgg(C/T)gcatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED26 Gene

Variant ID Type Subtype PubMed ID
nsv911167 CNV Loss 21882294
nsv510757 CNV Loss 20534489
esv2718266 CNV Deletion 23290073
esv2674048 CNV Deletion 23128226

Variation tolerance for MED26 Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MED26 Gene

Disorders for MED26 Gene

Relevant External Links for MED26

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED26

No disorders were found for MED26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED26 Gene

Publications for MED26 Gene

  1. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. (PMID: 9989412) Ryu S. … Tjian R. (Nature 1999) 2 3 4 67
  2. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  3. MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex. (PMID: 25575120) Takahashi H. … Hatakeyama S. (Nat Commun 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for MED26 Gene

Sources for MED26 Gene

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