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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MED26 Gene

protein-coding   GIFtS: 49
GCID: GC19M016685

Mediator Complex Subunit 26

(Previous names: cofactor required for Sp1 transcriptional activation, subunit...)
(Previous symbol: CRSP7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mediator Complex Subunit 261 2 3     ARC702 3
CRSP71 2 3 5     CRSP Complex Subunit 72 3
Cofactor Required For Sp1 Transcriptional Activation, Subunit 7, 70kDa1 2     CRSP702 5
Activator-Recruited Cofactor 70 KDa Component2 3     Cofactor Required For Sp1 Transcriptional Activation, Subunit 7 (70kD)2
Cofactor Required For Sp1 Transcriptional Activation Subunit 72 3     Mediator Of RNA Polymerase II Transcription Subunit 262
Transcriptional Coactivator CRSP702 3     

External Ids:    HGNC: 23761   Entrez Gene: 94412   Ensembl: ENSG000001050857   OMIM: 6050435   UniProtKB: O954023   

Export aliases for MED26 gene to outside databases

Previous GC identifers: GC19M016546 GC19M016254


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MED26 Gene:
The activation of gene transcription is a multistep process that is triggered by factors that recognize
transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation
by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required
for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein
is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which
interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and
cofactors. (provided by RefSeq, Jul 2008)

GeneCards Summary for MED26 Gene: 
MED26 (mediator complex subunit 26) is a protein-coding gene. Diseases associated with MED26 include conjunctivitis, and thyroiditis, and among its related super-pathways are Gene Expression and Axon guidance. GO annotations related to this gene include RNA polymerase II transcription cofactor activity and transcription coactivator activity. An important paralog of this gene is ENSG00000141979.

UniProtKB/Swiss-Prot: MED26_HUMAN, O95402
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED26 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MED26 gene promoter:
         Max1   GR   Meis-1b   RORalpha1   GATA-6   Msx-1   GR-alpha   Meis-1a   c-Myc   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED26 promoter sequence
   Search SABiosciences Chromatin IP Primers for MED26

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

MED26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED26 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M016685:  view genomic region     (about GC identifiers)

Start:
16,685,718 bp from pter      End:
16,739,873 bp from pter
Size:
54,156 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MED26_HUMAN, O95402 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 26  
Size: 600 amino acids; 65446 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Subcellular location: Nucleus (Probable)
Secondary accessions: A1A4S3 Q0VGB6
Alternative splicing: 2 isoforms:  O95402-1   O95402-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MED26: NX_O95402

Explore proteomics data for MED26 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95402

  • MED26 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MED26 Protein Expression
    REFSEQ proteins: NP_004822.2  
    ENSEMBL proteins: 
     ENSP00000263390   ENSP00000469434   ENSP00000471040   ENSP00000472706   ENSP00000472880  
    Reactome Protein details: O95402
    Human Recombinant Protein Products for MED26: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MED26
    GenScript Custom Purified and Recombinant Proteins Services for MED26
    Novus Biologicals MED26 Proteins
    Novus Biologicals MED26 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MED26 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0016592mediator complex IDA15989967

    MED26 for ontologies           About GeneDecksing



    MED26 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for MED26 

    Assay Products for MED26: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED26 
    Cloud-Clone Corp. CLIAs for MED26


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR003617 TFIIS/CRSP70_N_sub
     IPR017923 TFIIS_N

    Graphical View of Domain Structure for InterPro Entry O95402

    ProtoNet protein and cluster: O95402

    UniProtKB/Swiss-Prot: MED26_HUMAN, O95402
    Similarity: Belongs to the Mediator complex subunit 26 family
    Similarity: Contains 1 TFIIS N-terminal domain


    MED26 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED26_HUMAN, O95402
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IDA15989967
    GO:0003677DNA binding IEA--
    GO:0003713transcription coactivator activity TAS9989412
    GO:0005515protein binding IPI--
         
    MED26 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MED26:
     Decreased G3BP1 protein expres  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MED26 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MED26

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MED26 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MED26 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED26
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate MED26 (see all 45):
    hsa-miR-582-3p hsa-miR-15a hsa-miR-29a hsa-miR-503 hsa-miR-3074-3p hsa-miR-507 hsa-miR-124 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidMED26 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MED26
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED26

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of MED26

    Clone
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    OriGene clones in human, mouse for MED26 (see all 5)
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    GenScript: all cDNA clones in your preferred vector: MED26 (NM_004831)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED26
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED26
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                         Customized lentivirus expression plasmids for stable overexpression of MED26 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED26


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MED26 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    2Axon guidance
    Developmental Biology0.69
    3Transcriptional Regulation of White Adipocyte Differentiation
    Transcriptional Regulation of White Adipocyte Differentiation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for MED26
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation
    Generic Transcription Pathway
    Gene Expression



    MED26 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MED26

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/150 Interacting proteins for MED26 (O954021, 3 ENSP000002633904) via UniProtKB, MINT, STRING, and/or I2D (see all 150)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000234258P349313, ENSP000003964864I2D: score=1 STRING: ENSP00000396486
    ENSG00000206383P349313I2D: score=1 
    ENSG00000236251P349313I2D: score=1 
    HSPA1LP349313I2D: score=1 
    SMN2Q166373, ENSP000003701194I2D: score=1 STRING: ENSP00000370119
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA15989967
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--

    MED26 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MED26

    Search CenterWatch for drugs/clinical trials and news about MED26

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MED26 gene: 
    NM_004831.3  

    Unigene Cluster for MED26:

    Mediator complex subunit 26
    Hs.715040  [show with all ESTs]
    Unigene Representative Sequence: AK128435
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000597244 ENST00000263390(uc002nen.1) ENST00000598492 ENST00000598608
    ENST00000601478 ENST00000600060
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED26
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate MED26 (see all 45):
    hsa-miR-582-3p hsa-miR-15a hsa-miR-29a hsa-miR-503 hsa-miR-3074-3p hsa-miR-507 hsa-miR-124 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidMED26 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MED26
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED26
    Clone
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    GenScript: all cDNA clones in your preferred vector: MED26 (NM_004831)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED26
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED26
    Sirion Biotech Customized lentivirus for stable overexpression of MED26 
                         Customized lentivirus expression plasmids for stable overexpression of MED26 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MED26
    OriGene qSTAR qPCR primer pairs in human, mouse for MED26
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED26
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED26
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED26

    Additional mRNA sequence: 

    AF104253.1 AK094597.1 AK128435.1 AK313778.1 BC030138.2 BC047040.1 BC063628.1 BC105951.1 
    BC105952.1 BC105953.1 BC110430.1 BC127214.1 BC127215.1 BC143047.1 

    9 DOTS entries:

    DT.75110303  DT.102830124  DT.91658190  DT.75150916  DT.87015648  DT.100775665  DT.91852061  DT.95263572 
    DT.97768234 

    24/76 AceView cDNA sequences (see all 76):

    CB143761 CO249884 AI949529 AK128435 BU625273 BC063628 AA570708 AW768563 
    AL135584 AA716558 AI889732 CR603051 BX281632 BE744405 BC047040 BU731822 
    AA748587 AI871690 NM_004831 BM707960 AF104253 CR601122 CB241374 BG056795 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MED26 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTATTTTAA
    MED26 Expression
    About this image


    See MED26 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MED26

    SOURCE GeneReport for Unigene cluster: Hs.715040
        SABiosciences Custom PCR Arrays for MED26
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MED26
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED26
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED26
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED26

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MED26 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med261 , 5 mediator complex subunit 261, 5 83.79(n)1
    86.39(a)1
      8 (35.08 cM)5
    706251  NM_027485.41  NP_081761.21 
     724945585 
    chicken
    (Gallus gallus)
    Aves MED261 mediator complex subunit 26 67.6(n)
    70.53(a)
      771278  XM_001234570.2  XP_001234571.1 
    lizard
    (Anolis carolinensis)
    Reptilia MED266
    Uncharacterized protein
    55(a)
    1 → many
    AAWZ02038800(2502-4175)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.120952 Xenopus laevis CRSP70-like protein mRNA, complete cds 74.24(n)    AF395742.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.114942 Danio rerio CRSP70 mRNA, complete cds 76.05(n)    AY034615.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED266
    Mediator complex subunit 26
    7(a)
    1 → many
    4(799080-809604)


    ENSEMBL Gene Tree for MED26 (if available)
    TreeFam Gene Tree for MED26 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MED26 gene
    ENSG000001419792  
    2 SIMAP similar genes for MED26 using alignment to 5 protein entries:     MED26_HUMAN (see all proteins):
    TCEA1    TCEA2

    MED26 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1068 SNPs in MED26 are shown (see all 1068)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1423675811,2
    --16685256(+) GGGAAC/TTAAAA 1 -- ds50010--------
    rs722183481,2
    C--16685452(+) GCTAT-/GGGAGC 1 -- ds50010--------
    rs1924728041,2
    --16685487(+) GCCAGA/GTAAAG 1 -- ds50010--------
    rs72488571,2
    C,F,H--16685638(+) TCTGGG/ATGTTC 1 -- ds500111Minor allele frequency- A:0.06NS EA NA WA 1304
    rs1845229121,2
    --16685661(+) CCACAA/GTCCAG 1 -- ds50010--------
    rs1893552951,2
    --16685682(+) ATTTGC/GTTGTG 1 -- ds50010--------
    rs1996028261,2
    C--16685749(-) GGAAAA/TANNNN 1 -- ut310--------
    rs1815221881,2
    --16685889(+) GACAAA/CTAACC 1 -- ut310--------
    rs792669301,2
    C--16685939(+) CCAGCA/GTACAG 1 -- ut310--------
    rs1853700181,2
    --16686058(+) ACAGGA/CAGGGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MED26 (16685718 - 16739873 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MED26:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2674048CNV Deletion23128226
    esv2718266CNV Deletion23290073
    nsv911167CNV Loss21882294
    nsv510757CNV Loss20534489

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MED26
    DNA2.0 Custom Variant and Variant Library Synthesis for MED26

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605043    OMIM disorders: --

    3 diseases for MED26:    About MalaCards
    conjunctivitis    thyroiditis    neuronitis


    MED26 for disorders           About GeneDecksing


    Export disorders for MED26 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MED26 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with MED26)
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    1. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. (PubMed id 9989412)1, 2, 3 Ryu S.... Tjian R. (1999)
    2. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
    3. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S....Conaway R.C. (2004)
    4. Composite co-activator ARC mediates chromatin-directed transcriptional activation. (PubMed id 10235267)1, 2 Naeaer A.M....Tjian R. (1999)
    5. Identification of the hypoxia-inducible factor 2a nucl ear interactome in melanoma cells reveals master proteins involved in melanoma d evelopment. (PubMed id 23275444)1 Steunou A.L....Nieto L. (2013)
    6. A conserved Mediator-CDK8 kinase module association re gulates Mediator-RNA polymerase II interaction. (PubMed id 23563140)1 Tsai K.L....Asturias F.J. (2013)
    7. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    8. Human mediator subunit MED26 functions as a docking s ite for transcription elongation factors. (PubMed id 21729782)1 Takahashi H....Conaway J.W. (2011)
    9. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. (PubMed id 20508642)1 Krebs A.R....Tora L. (2010)
    10. Streamlined analysis schema for high-throughput ident ification of endogenous protein complexes. (PubMed id 20133760)1 Malovannaya A....Qin J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9441 HGNC: 2376 AceView: CRSP7 Ensembl:ENSG00000105085 euGenes: HUgn9441
    ECgene: MED26 H-InvDB: MED26

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MED26 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MED26 gene:
    Search GeneIP for patents involving MED26

    GeneCards and IP:
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