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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MED25 Gene

protein-coding   GIFtS: 53
GCID: GC19P050321

mediator complex subunit 25

(Previous names: mediator of RNA polymerase II transcription, subunit 25...)
 Explore 10 diseases affiliated with
MED25 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MED25    

Aliases
for MED25 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mediator Complex Subunit 251 2 3     TCBAP07581
ARC921 2 3 5     Mediator Of RNA Polymerase II Transcription, Subunit 25 Homolog (S. Cerevisiae)1
ACID11 2 3     P782
PTOV22 3 5     ARC/Mediator Transcriptional Coactivator Subunit2
Activator Interaction Domain-Containing Protein 12 3     Mediator Of RNA Polymerase II Transcription Subunit 252
Activator-Recruited Cofactor 92 KDa Component2 3     Mediator Of RNA Polymerase II Transcription, Subunit 25 Homolog2
CMT2B22 5     Prostate-Derived Protein 78 KDa2
DKFZp434K05121     P782

External Ids:    HGNC: 288451   Entrez Gene: 818572   Ensembl: ENSG000001049737   OMIM: 6101975   UniProtKB: Q71SY53   

Export aliases for MED25 gene to outside databases

Previous GC identifers: GC17P017580 GC17P017321 GC19P055016 GC19P046697


Summaries
for MED25 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MED25:
This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is
required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin
modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth
disease type 2B2. (provided by RefSeq, Apr 2010)

UniProtKB/Swiss-Prot: MED25_HUMAN, Q71SY5
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription

Gene Wiki entry for MED25


Genomic Views
for MED25 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MED25 gene promoter:
         Sp1   NF-kappaB1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MED25 promoter sequence
   Search SABiosciences Chromatin IP Primers for MED25

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

MED25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED25 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P050321:  view genomic region     (about GC identifiers)

Start:
 50,321,536 bp from pter      End:
 50,340,237 bp from pter
Size:
 18,702 bases      Orientation:
 plus strand

Proteins
for MED25 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MED25_HUMAN, Q71SY5 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 25  
Size: 747 amino acids; 78171 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in
supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct
subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CREBBP. Interacts with ESR1,
GR, RARA, RXRA and THRB in a ligand-dependent fashion. Binds the Herpes simplex virus activator VP16
Subcellular location: Nucleus
Sequence caution: Sequence=AAG15589.1; Type=Erroneous initiation; Sequence=CAB66680.1; Type=Frameshift; Positions=567;
4 PDB 3D structures from and Proteopedia for MED25:
2KY6 (3D)        2L23 (3D)        2L6U (3D)        2XNF (3D)    
Secondary accessions: A8K095 O95783 Q6P143 Q6QMH5 Q707U4 Q8TB55 Q9H0L5 Q9HB34
Alternative splicing: 5 isoforms:  Q71SY5-1   Q71SY5-2   Q71SY5-3   Q71SY5-4   Q71SY5-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MED25: NX_Q71SY5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q71SY5

    • MED25 Protein expression data from MOPED and PaxDb:    About this image 
    MED25 Protein Expression
    REFSEQ proteins: NP_112235.2  
    ENSEMBL proteins: 
     ENSP00000326767   ENSP00000437496  
    Reactome Protein details: Q71SY5
    Human Recombinant Protein Products for MED25: 
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    OriGene Protein Over-expression Lysate: MED25
    OriGene Custom Protein Services for MED25 
    GenScript Custom Purified and Recombinant Proteins Services for MED25
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MED25

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--

    MED25 for ontologies           About GeneDecksing



    MED25 Antibody Products: 
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    Uscn Antibodies for MED25
    ThermoFisher Antibody for MED25

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    Uscn ELISAs and CLIAs for MED25

    Protein Domains /
    Families
    for MED25 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MED25 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR021406 Mediator_Med25_NR-box
     IPR021397 Mediator_Med25_SD1
     IPR021419 Mediator_Med25_VWA
     IPR021394 Mediator_Med25

    Graphical View of Domain Structure for InterPro Entry Q71SY5

    ProtoNet protein and cluster: Q71SY5

    UniProtKB/Swiss-Prot: MED25_HUMAN, Q71SY5
    Similarity: Belongs to the Mediator complex subunit 25 family


    Function
    for MED25 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED25_HUMAN, Q71SY5
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
    polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
    proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
    interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
    with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17641689
    GO:0008134transcription factor binding IPI17641689
    GO:0042974retinoic acid receptor binding IPI17641689
    GO:0046965retinoid X receptor binding IPI17641689
         
    MED25 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MED25 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: MED25
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED25
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MED25
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED25 (see all 4)
    OriGene shRNA RFP: MED25
    OriGene siRNA: MED25
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED25
    Sirion Biotech Custom design and validation of potent shRNA sequences against MED25 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of MED25 
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED25 (see all 2)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MED25 (NM_030973)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED25 

    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED25


    Pathways & Interactions
    for MED25 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    		Generic Transcription Pathway1.00
    		Gene Expression0.46
    2Transcriptional Regulation of White Adipocyte Differentiation
    		Transcriptional Regulation of White Adipocyte Differentiation1.00
    3Axon guidance
    		Developmental Biology0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for MED25
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation
    Generic Transcription Pathway
    Gene Expression



    MED25 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MED25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/77 Interacting proteins for MED25 (Q71SY52, 3 ENSP000003267674) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RARAP102762, 3, ENSP000002540664MINT-5210199 MINT-5210070 MINT-5210046 MINT-5209882 MINT-5210176 MINT-5209983 MINT-5210334 MINT-5209938 MINT-5210212 MINT-5210090 I2D: score=4 STRING: ENSP00000254066
    NR3C1P041502, 3, ENSP000002315094MINT-5210024 I2D: score=2 STRING: ENSP00000231509
    ABL1P005192, 3, ENSP000003614234MINT-7217845 I2D: score=1 STRING: ENSP00000361423
    LCKP062392, 3, ENSP000003378254MINT-7217863 I2D: score=1 STRING: ENSP00000337825
    RXRAP197932, 3, ENSP000004196924MINT-5210379 MINT-5210002 MINT-5210351 MINT-5210362 I2D: score=4 STRING: ENSP00000419692
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP17641689
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0035563positive regulation of chromatin binding IMP17641689
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA17641689

    MED25 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MED25 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MED25
    Search CenterWatch for drugs/clinical trials and news about MED25 

    Transcripts
    for MED25 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MED25 gene: 
    NM_030973.3  

    Unigene Cluster for MED25:

    Mediator complex subunit 25
    Hs.656639  [show with all ESTs]
    Unigene Representative Sequence: AK055844
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312865(uc010enl.2 uc002ppw.2 uc010ybe.2 uc002ppx.1)
    ENST00000538643

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED25 (see all 4)
    OriGene shRNA RFP: MED25
    OriGene siRNA: MED25
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED25
    Sirion Biotech Custom design and validation of potent shRNA sequences against MED25 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED25 (see all 2)
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    GenScript: all cDNA clones in your preferred vector: MED25 (NM_030973)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED25
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED25 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED25
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED25
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED25

    Additional cDNA sequence: 

    AF261072.1 AJ617479.1 AK055844.1 AK289460.1 AK298897.1 AL136746.1 AY533507.1 BC021543.1 
    BC024312.2 BC065297.1 EU392499.1 EU392500.1 EU392501.1 EU392502.1 EU392503.1 EU392504.1 
    EU392505.1 EU392506.1 EU392507.1 EU392508.1 EU392509.1 EU392510.1 EU392511.1 EU392512.1 
    EU392513.1 EU392514.1 EU392515.1 EU392516.1 EU392517.1 EU392518.1 EU392519.1 

    13 DOTS entries:

    DT.40250284  DT.40296253  DT.91843061  DT.100024478  DT.100772812  DT.95220704  DT.121445351  DT.91968960 
    DT.100772814  DT.121445335  DT.91693970  DT.91727147  DT.100772815 

    24/594 AceView cDNA sequences (see all 594):

    AI244276 BU789592 BG770032 AY358168 BU783766 AI865787 AW849707 BU195461 
    BC065486 CF127140 BF732211 BF116023 AW008444 AI927574 AI432820 AI371847 
    AF447873 BG386162 AI468833 CA774656 AI754593 AW849348 AA373480 AI352416 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MED25 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                                                                                                              
    SP2:                    -                                                                                                         
    SP3:                                                                                                                    -         
    SP4:                                                                                                                              
    SP5:                                                                                                  -                           


    ECgene alternative splicing isoforms for MED25

    Expression
    for MED25 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MED25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATCTCATCT
    MED25 Expression
    About this image

    MED25 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartLeft VentricleHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MED25 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MED25

    SOURCE GeneReport for Unigene cluster: Hs.656639

    UniProtKB/Swiss-Prot: MED25_HUMAN, Q71SY5
    Tissue specificity: Ubiquitously expressed. Highest levels in brain, heart, kidney, peripheral leukocytes, placenta,
    skeletal muscle and spleen

        SABiosciences Custom PCR Arrays for MED25
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED25
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED25

    Orthologs
    for MED25 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MED25 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 73(a)
    71(a)
    		 many ↔ many
    many ↔ many
    		 GL344519.1(622-14558)
    6(80160082-80180954)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.44002 Xenopus laevis transcribed sequence with moderate similarity more 78.71(n)    CD253032.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.250872 Danio rerio cDNA clone MGC63555 IMAGE3817335, complete more 76.78(n)    BC058057.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta MED256
    CG136096
    		 --
    		 21(a)
    18(a)
    		 many ↔ many
    many ↔ many
    		 3R(15834718-15837434)
    3R(20052745-20054260)


    ENSEMBL Gene Tree for MED25 (if available)
    TreeFam Gene Tree for MED25 (if available) 

    Paralogs
    for MED25 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MED25 gene
    PTOV12  
    2 SIMAP similar genes for MED25 using alignment to 23 protein entries:     MED25_HUMAN (see all proteins):
    PTOV1    FP3184

    MED25 for paralogs           About GeneDecksing



    Genomic Variants
    for MED25 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/415 NCBI SNPs in MED25 are shown (see all 415)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1457700661,2
    		C,Fpathogenic47252349(+) TGGCGC/TCCCCA 2 A V mis12Minor allele frequency- T:0.00NA EU 4121
    rs1120138331,2
    		C--46696429(+) TTAGCC/TGAGGA 1 -- us2k12Minor allele frequency- T:0.03NA 122
    rs735922741,2
    		C--46696976(+) TCCCAG/CAAAAC 1 -- us2k11Minor allele frequency- C:0.50WA 2
    rs778222291,2
    		F--46697036(+) CTTTTC/AGGGGG 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs802525331,2
    		--46697795(+) CAGCAT/CTCCCA 1 -- us2k13Minor allele frequency- C:0.11CSA WA EA 240
    rs104223861,2
    		C,F--46698442(+) AGGAAG/TGGCTG 1 -- int1 trp31Minor allele frequency- T:0.07WA 118
    rs16405111,2
    		C--46698732(+) CTCCCC/TTCCCA 1 -- int1 trp32Minor allele frequency- T:0.00MN NA 186
    rs348383551,2
    		C--46701932(+) TGCCT-/TGTAAT 1 -- int12Minor allele frequency- T:0.25NA CSA 4
    rs735922811,2
    		C--46701996(+) GAGATC/AGCACC 1 -- int11Minor allele frequency- A:0.50WA 2
    rs116684731,2
    		H--46702035(+) actgaA/Gaccct 1 -- int10--------

    HapMap Linkage Disequilibrium report for MED25 (50321536 - 50340237 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for MED25
         2 CNVs: 5114 32261
    Human Gene Mutation Database (HGMD): MED25

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MED25
    DNA2.0 Custom Variant and Variant Library Synthesis for MED25

    Disorders / Diseases
    for MED25 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MED25 for disorders           About GeneDecksing

    OMIM gene information: 610197   
    OMIM disorders: 605589  
    UniProtKB/Swiss-Prot: MED25_HUMAN, Q71SY5
  • Defects in MED25 are the cause of Charcot-Marie-Tooth disease type 2B2 (CMT2B2) [MIM:605589]. It is a
    • recessive axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by
    progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms.
    Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and
    histopathology: primary peripheral demyelinating neuropathies(designated CMT1 when they are dominantly inherited) and
    primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal
    regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and
    progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced

    10 diseases for MED25:    About MalaCards
    charcot-marie-tooth disease type 2b2    charcot-marie-tooth disease type 2    charcot-marie-tooth disease    tooth disease
    axonal neuropathy    prostatitis    kaposi's sarcoma    neuropathy
    sarcoma    cholesterol


    Export disorders for MED25 gene to outside databases

    Publications
    for MED25 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MED25 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with MED25)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. Identification of the variant Ala335Val of MED25 as r esponsible for CMT2B2: molecular data, functional studies of the SH3 recognitio n motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A a nimal models. (PubMed id 19290556)1, 2, 9 Leal A....Rautenstrauss B. (2009)
    3. A prostate-derived cDNA that is mapped to human chromosome 19 encodes a novel protein. (PubMed id 12163014)1, 2, 9 Wang C.... Steiner M.S. (2002)
    4. NMR structure of the human Mediator MED25 ACID domain. (PubMed id 20974256)1, 2 Bontems F.... Monte D. (2010)
    5. MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation. (PubMed id 17641689)1, 2 Lee H.-K.... Um S.-J. (2007)
    6. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator. (PubMed id 14983011)1, 2 Yang F.... Naeaer A.M. (2004)
    9. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S....Conaway R.C. (2004)
    10. A novel docking site on Mediator is critical for activation by VP16 in mammalian cells. (PubMed id 14657022)1, 2 Mittler G.... Meisterernst M. (2003)

    External Searches for MED25 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MED25 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81857 HGNC: 28845 AceView: PTOV1andARC92 Ensembl:ENSG00000104973 euGenes: HUgn81857
    ECgene: MED25 H-InvDB: MED25

    Other Databases showing MED25 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MED25 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MED25 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MED25 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MED25 gene:
    Search GeneIP for patents involving MED25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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