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Aliases for MED25 Gene

Aliases for MED25 Gene

  • Mediator Complex Subunit 25 2 3 4 5
  • Activator Interaction Domain-Containing Protein 1 3 4
  • Activator-Recruited Cofactor 92 KDa Component 3 4
  • ACID1 3 4
  • ARC92 3 4
  • PTOV2 3 4
  • P78 3 4
  • Mediator Of RNA Polymerase II Transcription, Subunit 25 Homolog (S. Cerevisiae) 2
  • Mediator Of RNA Polymerase II Transcription, Subunit 25 Homolog 3
  • ARC/Mediator Transcriptional Coactivator Subunit 3
  • Prostate-Derived Protein 78 KDa 3
  • TCBAP0758 3
  • CMT2B2 3
  • BVSYS 3

External Ids for MED25 Gene

Previous GeneCards Identifiers for MED25 Gene

  • GC17P017580
  • GC17P017321
  • GC19P055016
  • GC19P050321
  • GC19P046697

Summaries for MED25 Gene

Entrez Gene Summary for MED25 Gene

  • This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. [provided by RefSeq, Apr 2010]

GeneCards Summary for MED25 Gene

MED25 (Mediator Complex Subunit 25) is a Protein Coding gene. Diseases associated with MED25 include charcot-marie-tooth disease, type 2b2 and basel-vanagait-smirin-yosef syndrome. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include transcription factor binding and retinoid X receptor binding. An important paralog of this gene is PTOV1.

UniProtKB/Swiss-Prot for MED25 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription.

Gene Wiki entry for MED25 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED25 Gene

Genomics for MED25 Gene

Regulatory Elements for MED25 Gene

Promoters for MED25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MED25 on UCSC Golden Path with GeneCards custom track

Genomic Location for MED25 Gene

Chromosome:
19
Start:
49,818,279 bp from pter
End:
49,840,384 bp from pter
Size:
22,106 bases
Orientation:
Plus strand

Genomic View for MED25 Gene

Genes around MED25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED25 Gene

Proteins for MED25 Gene

  • Protein details for MED25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q71SY5-MED25_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 25
    Protein Accession:
    Q71SY5
    Secondary Accessions:
    • A8K095
    • B9TX30
    • O95783
    • Q6P143
    • Q6QMH5
    • Q707U4
    • Q8TB55
    • Q9H0L5
    • Q9HB34

    Protein attributes for MED25 Gene

    Size:
    747 amino acids
    Molecular mass:
    78171 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CREBBP. Interacts with ESR1, GR, RARA, RXRA and THRB in a ligand-dependent fashion. Binds the Herpes simplex virus activator VP16.
    SequenceCaution:
    • Sequence=AAG15589.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB66680.1; Type=Frameshift; Positions=567; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MED25 Gene

    Alternative splice isoforms for MED25 Gene

neXtProt entry for MED25 Gene

Proteomics data for MED25 Gene at MOPED

Post-translational modifications for MED25 Gene

  • Ubiquitination at Lys 197 and Lys 484
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MED25 Gene

Domains & Families for MED25 Gene

Gene Families for MED25 Gene

Protein Domains for MED25 Gene

Graphical View of Domain Structure for InterPro Entry

Q71SY5

UniProtKB/Swiss-Prot:

MED25_HUMAN :
  • Belongs to the Mediator complex subunit 25 family.
Family:
  • Belongs to the Mediator complex subunit 25 family.
genes like me logo Genes that share domains with MED25: view

Function for MED25 Gene

Molecular function for MED25 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription.

Gene Ontology (GO) - Molecular Function for MED25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IPI 17641689
genes like me logo Genes that share ontologies with MED25: view
genes like me logo Genes that share phenotypes with MED25: view

Human Phenotype Ontology for MED25 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MED25 Gene

MGI Knock Outs for MED25:

Animal Model Products

miRNA for MED25 Gene

miRTarBase miRNAs that target MED25

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MED25 Gene

Localization for MED25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED25 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED25 Gene COMPARTMENTS Subcellular localization image for MED25 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for MED25 Gene

Pathways & Interactions for MED25 Gene

genes like me logo Genes that share pathways with MED25: view

Gene Ontology (GO) - Biological Process for MED25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 17641689
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0048147 negative regulation of fibroblast proliferation IMP 17641689
GO:0071158 positive regulation of cell cycle arrest IMP 17641689
genes like me logo Genes that share ontologies with MED25: view

No data available for SIGNOR curated interactions for MED25 Gene

Drugs & Compounds for MED25 Gene

No Compound Related Data Available

Transcripts for MED25 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED25 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2: -
SP3: -
SP4:
SP5: -
SP6:

Relevant External Links for MED25 Gene

GeneLoc Exon Structure for
MED25
ECgene alternative splicing isoforms for
MED25

Expression for MED25 Gene

mRNA expression in normal human tissues for MED25 Gene

mRNA differential expression in normal tissues according to GTEx for MED25 Gene

This gene is overexpressed in Whole Blood (x4.7).

Protein differential expression in normal tissues from HIPED for MED25 Gene

This gene is overexpressed in NK cells (9.7), Testis (8.4), Placenta (8.1), and Fetal ovary (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED25 Gene



SOURCE GeneReport for Unigene cluster for MED25 Gene Hs.656639

mRNA Expression by UniProt/SwissProt for MED25 Gene

Q71SY5-MED25_HUMAN
Tissue specificity: Ubiquitously expressed. Highest levels in brain, heart, kidney, peripheral leukocytes, placenta, skeletal muscle and spleen.
genes like me logo Genes that share expression patterns with MED25: view

Protein tissue co-expression partners for MED25 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MED25 Gene

Orthologs for MED25 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED25 36
  • 86 (a)
OneToOne
MED25 35
  • 97.25 (n)
  • 96.51 (a)
cow
(Bos Taurus)
Mammalia MED25 35
  • 90.66 (n)
  • 95.84 (a)
MED25 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED25 36
  • 89 (a)
OneToOne
MED25 35
  • 89.95 (n)
  • 95.79 (a)
mouse
(Mus musculus)
Mammalia Med25 35
  • 85.41 (n)
  • 91.54 (a)
Med25 36
  • 92 (a)
OneToOne
Med25 16
oppossum
(Monodelphis domestica)
Mammalia MED25 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med25 35
  • 85.68 (n)
  • 93.42 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4400 35
tropical clawed frog
(Silurana tropicalis)
Amphibia med25 35
  • 68.05 (n)
  • 76.27 (a)
Str.10861 35
zebrafish
(Danio rerio)
Actinopterygii Dr.25087 35
fruit fly
(Drosophila melanogaster)
Insecta MED25 36
  • 23 (a)
OneToMany
Species with no ortholog for MED25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MED25 Gene

ENSEMBL:
Gene Tree for MED25 (if available)
TreeFam:
Gene Tree for MED25 (if available)

Paralogs for MED25 Gene

Paralogs for MED25 Gene

genes like me logo Genes that share paralogs with MED25: view

Variants for MED25 Gene

Sequence variations from dbSNP and Humsavar for MED25 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_063521 Charcot-Marie-Tooth disease 2B2 (CMT2B2)
VAR_073949 Basel-Vanagaite-Smirin-Yosef syndrome (BVSYS)
VAR_073950 -
rs1013322 -- 49,823,235(+) gagat(C/T)acagg intron-variant
rs1674140 -- 49,821,657(-) gtaat(C/T)tcagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED25 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv912269 CNV Loss 21882294
nsv470150 CNV Gain 18288195
dgv53n68 CNV Loss 17160897
nsv912272 CNV Loss 21882294
esv2659864 CNV Deletion 23128226

Variation tolerance for MED25 Gene

Residual Variation Intolerance Score: 40.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MED25 Gene

HapMap Linkage Disequilibrium report
MED25
Human Gene Mutation Database (HGMD)
MED25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED25 Gene

Disorders for MED25 Gene

MalaCards: The human disease database

(14) MalaCards diseases for MED25 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, type 2b2
  • charcot-marie-tooth disease type 2b2
basel-vanagait-smirin-yosef syndrome
  • basel-vanagaite-smirin-yosef syndrome
charcot-marie-tooth disease, axonal, type 2s
  • autosomal recessive axonal charcot-marie-tooth disease type 2
syndromic intellectual disability
encephalopathy, progressive, with or without lipodystrophy
  • peld
- elite association - COSMIC cancer census association via MalaCards
Search MED25 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MED25_HUMAN
  • Charcot-Marie-Tooth disease 2B2 (CMT2B2) [MIM:605589]: A recessive axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. {ECO:0000269 PubMed:19290556}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Basel-Vanagaite-Smirin-Yosef syndrome (BVSYS) [MIM:616449]: An autosomal recessive syndrome characterized by eye, brain, cardiac and palatal abnormalities as well as growth retardation, microcephaly and severe intellectual disability. {ECO:0000269 PubMed:25792360}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MED25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED25
genes like me logo Genes that share disorders with MED25: view

No data available for Genatlas for MED25 Gene

Publications for MED25 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models. (PMID: 19290556) Leal A. … Rautenstrauss B. (Neurogenetics 2009) 3 23
  3. A prostate-derived cDNA that is mapped to human chromosome 19 encodes a novel protein. (PMID: 12163014) Wang C. … Steiner M.S. (Biochem. Biophys. Res. Commun. 2002) 3 23
  4. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for MED25 Gene

Sources for MED25 Gene

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