Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MED24 Gene

Aliases for MED24 Gene

  • Mediator Complex Subunit 24 2 3 4 5
  • Cofactor Required For Sp1 Transcriptional Activation, Subunit 4, 100kDa 2 3
  • Thyroid Hormone Receptor-Associated Protein Complex 100 KDa Component 3 4
  • Vitamin D3 Receptor-Interacting Protein Complex 100 KDa Component 3 4
  • Cofactor Required For Sp1 Transcriptional Activation Subunit 4 3 4
  • Activator-Recruited Cofactor 100 KDa Component 3 4
  • Thyroid Hormone Receptor-Associated Protein 4 3 4
  • CRSP Complex Subunit 4 3 4
  • DRIP100 3 4
  • TRAP100 3 4
  • THRAP4 3 4
  • ARC100 3 4
  • CRSP4 3 4
  • Vitamin D3 Receptor-Interacting Protein Complex Component DRIP100 3
  • Mediator Of RNA Polymerase II Transcription, Subunit 24 Homolog 3
  • Mediator Of RNA Polymerase II Transcription Subunit 24 3
  • Thyroid Hormone Receptor Associated Protein 4 2
  • KIAA0130 4
  • HTRAP100 4
  • CRSP100 3
  • MED5 3

External Ids for MED24 Gene

Previous HGNC Symbols for MED24 Gene

  • THRAP4
  • CRSP4

Previous GeneCards Identifiers for MED24 Gene

  • GC17M035429
  • GC17M038175
  • GC17M033969

Summaries for MED24 Gene

Entrez Gene Summary for MED24 Gene

  • This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MED24 Gene

MED24 (Mediator Complex Subunit 24) is a Protein Coding gene. Diseases associated with MED24 include Transposition Of The Great Arteries. Among its related pathways are PEDF Induced Signaling and Thyroid hormone signaling pathway. Gene Ontology (GO) annotations related to this gene include receptor activity and transcription cofactor activity.

UniProtKB/Swiss-Prot for MED24 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED24 Gene

Additional gene information for MED24 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED24 Gene

Genomics for MED24 Gene

GeneHancer (GH) Regulatory Elements for MED24 Gene

Promoters and enhancers for MED24 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I040053 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 565.2 +6.9 6942 1.8 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF766 MED24 MED1 SMARCE1 CDK12 GC17P040059 SNORD124
GH17I040062 Enhancer 0.8 ENCODE dbSUPER 550.8 -0.6 -594 0.2 ZSCAN4 ZBTB8A ZIC2 PRDM2 GLIS2 GLIS1 ZBTB33 ZNF423 MED24 THRA GC17P040059 GC17P040067
GH17I040059 Enhancer 0.4 dbSUPER 584 +1.4 1423 0.9 ZBTB48 ZNF341 ZBTB17 MED24 GC17P040059 THRA
GH17I040306 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 72.1 -256.3 -256310 22.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 RARA MED1 SMARCE1 SNORD124 CDK12 MED24 MSL1 TMEM99 CDC6 WIPF2
GH17I040138 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 62.6 -79.1 -79124 3.2 ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 MCM3 CASC3 GC17M040140 MED1 SNORD124 SMARCE1 CDK12 MED24 MSL1 STARD3 IGFBP4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MED24 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MED24 gene promoter:

Genomic Locations for MED24 Gene

Genomic Locations for MED24 Gene
chr17:40,019,097-40,061,215
(GRCh38/hg38)
Size:
42,119 bases
Orientation:
Minus strand
chr17:38,175,350-38,217,468
(GRCh37/hg19)

Genomic View for MED24 Gene

Genes around MED24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED24 Gene

Proteins for MED24 Gene

  • Protein details for MED24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75448-MED24_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 24
    Protein Accession:
    O75448
    Secondary Accessions:
    • A8K4S5
    • B3KMR9
    • Q14143
    • Q9NNY5

    Protein attributes for MED24 Gene

    Size:
    989 amino acids
    Molecular mass:
    110305 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with AR.
    SequenceCaution:
    • Sequence=BAA09479.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MED24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED24 Gene

Post-translational modifications for MED24 Gene

  • Ubiquitination at posLast=717717, isoforms=2721, and posLast=856856

No data available for DME Specific Peptides for MED24 Gene

Domains & Families for MED24 Gene

Gene Families for MED24 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MED24 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O75448

UniProtKB/Swiss-Prot:

MED24_HUMAN :
  • Belongs to the Mediator complex subunit 24 family.
Family:
  • Belongs to the Mediator complex subunit 24 family.
genes like me logo Genes that share domains with MED24: view

Function for MED24 Gene

Molecular function for MED24 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Phenotypes From GWAS Catalog for MED24 Gene

Gene Ontology (GO) - Molecular Function for MED24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IDA 10198638
GO:0003712 transcription cofactor activity IDA 12218053
GO:0003713 transcription coactivator activity IEA --
GO:0004402 histone acetyltransferase activity IEA --
GO:0004872 receptor activity IDA 12218053
genes like me logo Genes that share ontologies with MED24: view
genes like me logo Genes that share phenotypes with MED24: view

Animal Models for MED24 Gene

MGI Knock Outs for MED24:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MED24 Gene

Localization for MED24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED24 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MED24 gene
Compartment Confidence
nucleus 5
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for MED24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 10235267
GO:0005654 nucleoplasm TAS --
GO:0016592 mediator complex IEA,NAS 9653119
genes like me logo Genes that share ontologies with MED24: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MED24 Gene

Pathways & Interactions for MED24 Gene

genes like me logo Genes that share pathways with MED24: view

Pathways by source for MED24 Gene

Gene Ontology (GO) - Biological Process for MED24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006366 transcription by RNA polymerase II IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with MED24: view

No data available for SIGNOR curated interactions for MED24 Gene

Drugs & Compounds for MED24 Gene

(1) Drugs for MED24 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MED24 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MED24: view

Transcripts for MED24 Gene

Unigene Clusters for MED24 Gene

Mediator complex subunit 24:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED24 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7:
SP8: - - - - - -
SP9: - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - - - - - - -
SP11: - -
SP12: - - - - - - - - - -
SP13: - - - - - - - - -
SP14: - - - - - - - -
SP15: - - - - - - - - -
SP16: - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - -
SP18: - - - - - - - - - - - - -
SP19: - - - - - - - - - - - -
SP20: - - - - - - - - - -
SP21: - - - - - - - - -
SP22: - - - - -
SP23: - - - - - - - - - - - - -
SP24: - - - - - - - - -
SP25: - - - - - - - - - -
SP26:
SP27: - - - - - - - - - - - -
SP28: - - - - - - - - - - - - -
SP29: - - - - - - - - -
SP30:
SP31:
SP32:
SP33:
SP34:
SP35: - - - - - - - - - -
SP36: - - - - - - -
SP37: - - - - - - - - -
SP38:
SP39:
SP40:
SP41: - - - - -
SP42:
SP43:
SP44:

ExUns: 9f · 9g · 9h · 9i · 9j · 9k ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e · 12f ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7:
SP8:
SP9: - - - - -
SP10: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP11: - - -
SP12:
SP13:
SP14:
SP15:
SP16: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP17:
SP18: - - - -
SP19: - - - -
SP20:
SP21:
SP22: - - - -
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:
SP33:
SP34:
SP35:
SP36:
SP37:
SP38:
SP39: -
SP40:
SP41:
SP42:
SP43:
SP44:

ExUns: 19b ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b · 24c ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31a · 31b ^ 32a · 32b ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4:
SP5:
SP6:
SP7: - - - -
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - - - - - - - - - - - - - - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26: - - -
SP27:
SP28:
SP29:
SP30: - - -
SP31: - - -
SP32: - - -
SP33: -
SP34: -
SP35:
SP36:
SP37:
SP38:
SP39:
SP40:
SP41:
SP42: - -
SP43:
SP44: -

ExUns: 33a · 33b · 33c · 33d ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:
SP33:
SP34:
SP35:
SP36:
SP37:
SP38:
SP39:
SP40:
SP41:
SP42:
SP43:
SP44:

Relevant External Links for MED24 Gene

GeneLoc Exon Structure for
MED24
ECgene alternative splicing isoforms for
MED24

Expression for MED24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MED24 Gene

Protein differential expression in normal tissues from HIPED for MED24 Gene

This gene is overexpressed in Breast (19.8) and Blymphocyte (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MED24 Gene



Protein tissue co-expression partners for MED24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MED24 Gene:

MED24

SOURCE GeneReport for Unigene cluster for MED24 Gene:

Hs.462983

mRNA Expression by UniProt/SwissProt for MED24 Gene:

O75448-MED24_HUMAN
Tissue specificity: Ubiquitous. Abundant in skeletal muscle, heart and placenta.

Evidence on tissue expression from TISSUES for MED24 Gene

  • Nervous system(4.9)
  • Bone marrow(4.3)
  • Eye(4.2)
  • Lung(2.9)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with MED24: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED24 Gene

Orthologs for MED24 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED24 33 34
  • 99.7 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 92 (a)
OneToMany
-- 34
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MED24 33 34
  • 91.07 (n)
cow
(Bos Taurus)
Mammalia MED24 33 34
  • 90.39 (n)
rat
(Rattus norvegicus)
Mammalia Med24 33
  • 88.96 (n)
mouse
(Mus musculus)
Mammalia Med24 33 16 34
  • 88.86 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 79 (a)
OneToMany
-- 34
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves MED24 33 34
  • 81.46 (n)
lizard
(Anolis carolinensis)
Reptilia MED24 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491557 33
  • 72.45 (n)
African clawed frog
(Xenopus laevis)
Amphibia thrap4-prov 33
zebrafish
(Danio rerio)
Actinopterygii med24 33 34
  • 70.39 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta MED24_ANOGA 33
  • 48.6 (n)
fruit fly
(Drosophila melanogaster)
Insecta MED24 33 34
  • 45.04 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
OneToOne
Species where no ortholog for MED24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MED24 Gene

ENSEMBL:
Gene Tree for MED24 (if available)
TreeFam:
Gene Tree for MED24 (if available)

Paralogs for MED24 Gene

No data available for Paralogs for MED24 Gene

Variants for MED24 Gene

Sequence variations from dbSNP and Humsavar for MED24 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000016615 -- 40,039,670(-) G/A intron_variant
rs1000031474 -- 40,045,902(-) C/G intron_variant
rs1000086558 -- 40,038,239(-) A/G intron_variant
rs1000295672 -- 40,025,922(-) G/C genic_downstream_transcript_variant, intron_variant
rs1000570160 -- 40,021,968(-) G/A coding_sequence_variant, genic_downstream_transcript_variant, non_coding_transcript_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for MED24 Gene

Variant ID Type Subtype PubMed ID
esv3573064 CNV gain 25503493
nsv1146669 OTHER inversion 26484159

Variation tolerance for MED24 Gene

Residual Variation Intolerance Score: 7.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MED24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED24 Gene

Disorders for MED24 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MED24 Gene - From: GeneCards

Disorder Aliases PubMed IDs
transposition of the great arteries
  • transposition of the great arteries, dextro-looped 1
- elite association - COSMIC cancer census association via MalaCards
Search MED24 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MED24

genes like me logo Genes that share disorders with MED24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MED24 Gene

Publications for MED24 Gene

  1. MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X … Roeder RG (Molecular cell 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S … Conaway RC (Molecular cell 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. (PMID: 11867769) Kang YK … Roeder RG (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 22 58

Products for MED24 Gene