MED24 Gene
protein-coding GIFtS: 54
GCID: GC17M038175
|
|
mediator complex subunit 24(Previous names: thyroid hormone receptor associated protein 4, cofactor...)
(Previous symbols: THRAP4, CRSP4)
| |
Aliases
for MED24 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mediator Complex Subunit 241 2 3 | | Thyroid Hormone Receptor-Associated Protein 42 3 | | TRAP1001 2 3 5 | | Thyroid Hormone Receptor-Associated Protein Complex 100 KDa Component2 3 | | CRSP41 2 3 | | Vitamin D3 Receptor-Interacting Protein Complex 100 KDa Component2 3 | | DRIP1001 2 3 | | ARC1002 3 | | THRAP41 2 3 | | CRSP Complex Subunit 42 3 | | KIAA01301 3 5 | | Mediator Of RNA Polymerase II Transcription Subunit 242 | | CRSP1001 2 | | Mediator Of RNA Polymerase II Transcription, Subunit 24 Homolog2 | | Cofactor Required For Sp1 Transcriptional Activation, Subunit 4, 100kDa1 2 | | Vitamin D3 Receptor-Interacting Protein Complex Component DRIP1002 | | Thyroid Hormone Receptor Associated Protein 41 2 | | Trap1003 | | Activator-Recruited Cofactor 100 KDa Component2 3 | | HTRAP1001 | | Cofactor Required For Sp1 Transcriptional Activation Subunit 42 3 | | |
Export aliases for MED24 gene to outside databasesPrevious GC identifers: GC17M035429 GC17M033969 |
Summaries
for MED24 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MED24:
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptionalcoactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruitedby transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNApolymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variantsencoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MED24_HUMAN, O75448Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatoryproteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by directinteractions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complexwith RNA polymerase II and the general transcription factors
Gene Wiki entry for MED24
|
Genomic Views
for MED24 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MED24 gene promoter:
p53 Sp1 AP-1 p300
Other transcription factors
Search SABiosciences Chromatin IP Primers for MED24
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED24 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.1 Ensembl cytogenetic band: 17q21.1 HGNC cytogenetic band: 17q21.2MED24 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M038175: view genomic region
(about GC identifiers)
Start:
|
38,175,350 bp from pter |
End:
|
38,217,468 bp from pter |
Size:
|
42,119 bases |
Orientation:
|
minus strand |
|
Proteins
for MED24 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MED24_HUMAN, O75448 (See
protein sequence)Recommended Name: Mediator of RNA polymerase II transcription subunit 24 Size: 989 amino acids; 110305 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinctmodule termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module insupporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinctsubunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with AR
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAA09479.2; Type=Erroneous initiation;
Secondary accessions: A8K4S5 B3KMR9 Q14143 Q9NNY5Alternative splicing: 2 isoforms: O75448-1 O75448-2 Explore the universe of human proteins at neXtProt for MED24: NX_O75448
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75448
MED24 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001072986.1 NP_001254726.1 NP_055630.2
ENSEMBL proteins: ENSP00000377684 ENSP00000348610 ENSP00000377686 ENSP00000377685 ENSP00000435760 ENSP00000439148 ENSP00000393464 ENSP00000440100 ENSP00000443344 ENSP00000463751 ENSP00000463724 ENSP00000463484 ENSP00000392276 ENSP00000463043 ENSP00000438630 ENSP00000462646 ENSP00000438767 ENSP00000462539 ENSP00000463528 ENSP00000463480 ENSP00000464225 ENSP00000438802 ENSP00000402361 Reactome Protein details: O75448
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MED24 for ontologies About GeneDecksing
MED24 Antibody Products:
Assay Products for MED24: |
Protein
Domains /
Families
for MED24 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MED24 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O75448ProtoNet protein and cluster: O75448 UniProtKB/Swiss-Prot: MED24_HUMAN, O75448Similarity: Belongs to the Mediator complex subunit 24 family |
Function
for MED24 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MED24_HUMAN, O75448Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatoryproteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by directinteractions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complexwith RNA polymerase II and the general transcription factors
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED24 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED24 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MED24 (NM_014815) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MED24 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED24 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED24 |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
MED24 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for MED24:
Animal Models:
8 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Med24):
MED24 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MED24 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | | | 2 | HIV Infection | | | 3 | Transcriptional Regulation of White Adipocyte Differentiation | | | 4 | Axon guidance | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for MED24
1  GeneGo (Thomson Reuters) Pathway for MED24
4 
Reactome Pathways for MED24
MED24 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MED24
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/103 Interacting proteins for MED24 (O754482, 3 ENSP000003486104) via UniProtKB, MINT, STRING, and/or I2D (see all 103)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
NAS | -- | | GO:0006366 | transcription from RNA polymerase II promoter |
-- | -- | | GO:0006367 | transcription initiation from RNA polymerase II promoter |
TAS | -- | | GO:0010467 | gene expression |
TAS | -- | | GO:0016573 | histone acetylation |
-- | -- |
MED24 for ontologies About GeneDecksing
|
Drugs & Compounds
for MED24 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MED24 for compounds About GeneDecksing
 Browse Tocris compounds for MED24
3 Novoseek chemical compound relationships for MED24 gene About this table
Search CenterWatch for drugs/clinical trials and news about MED24
|
Transcripts
for MED24 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MED24 gene (3 alternative transcripts): NM_001079518.1 NM_001267797.1 NM_014815.3 Unigene Cluster for MED24: Mediator complex subunit 24 Hs.462983 [show with all ESTs]Unigene Representative Sequence: NM_01481518/35 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 35): ENST00000394126(uc010weq.2 uc010wer.2 uc010wes.2 uc010wet.2 uc002hts.3 uc010wfb.1)
ENST00000356271(uc010cwn.3) ENST00000394128(uc002htt.3 uc010weu.2 uc010wev.1)
ENST00000394127(uc002htu.3) ENST00000491466 ENST00000535508 ENST00000579364
ENST00000422942 ENST00000501516(uc010wfa.1 uc010wfc.1) ENST00000470126
ENST00000535071(uc010wew.1 uc010wex.1) ENST00000492176 ENST00000580720
ENST00000580885 ENST00000581058 ENST00000580921 ENST00000584782 ENST00000495586
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED24 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED24 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MED24 (NM_014815) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MED24 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED24 |
Additional cDNA sequence: AF055995.1 AF277379.1 AK022508.1 AK291040.1 AK293309.1 AK299864.1 AK300992.1 AK303502.1 AK303745.1 BC011375.1 D50920.1 EU392533.1 EU392534.1 EU392535.1 EU392536.1 EU392537.1 EU392538.1 EU392539.1 EU392540.1 EU392541.1 EU392542.1 EU392543.1 EU392544.1 EU392545.1 EU392546.1 EU392547.1 EU392548.1 EU392549.1 EU392550.1 EU392551.1 EU392552.1 EU392553.1 EU392554.1 NR_052017.1 24/40 DOTS entries (see all 40): DT.92446610 DT.120980045 DT.100030566 DT.100729255 DT.120980122 DT.120980121 DT.100794788 DT.95212192 DT.453007 DT.70101420 DT.102830372 DT.91953039 DT.95329126 DT.120980136 DT.92446601 DT.102830374 DT.120980104 DT.100718201 DT.100671636 DT.95329133 DT.120980117 DT.120980006 DT.95131104 DT.100794786 24/360 AceView cDNA sequences (see all 360): D50920 BQ958410 BM704761 AI346721 BQ888687 BU162877 BU149988 CB105741 BP356723 BF969030 BM693908 AA303181 AU125125 AW005255 BM461536 BQ650188 BU730123 AU121607 CD652191 BM834189 AU132071 BU542010 BM556394 CB105761
GeneLoc Exon Structure
5/44 Alternative Splicing Database (ASD) splice patterns (SP) for MED24 (see all 44) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | · | 4f | · | 4g | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e | · |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | - | | - | | | | | | - | | | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | - | | | | | | | | - | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | | | | | | | - | | | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | | | | | | | - | | | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | |
| ExUns: | 9f | · | 9g | · | 9h | · | 9i | · | 9j | · | 9k | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d | · | 12e | · | 12f | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19b | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · | 24b | · | 24c | ^ | 25 | ^ | 26a | · | 26b | ^ | 27a | · | 27b | · | 27c | ^ | 28a | · | 28b | ^ | 29 | ^ | 30a | · | 30b | ^ | 31a | · | 31b | ^ | 32a | · | 32b | ^ |
|---|
|
| SP1: | | | - | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | - | | | | |
| SP2: | | | - | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | - | | | | |
| SP3: | | | - | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 33a | · | 33b | · | 33c | · | 33d | · |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for MED24
|
Expression
for MED24 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MED24 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATAAATAAA
About this image
See MED24 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MED24
SOURCE GeneReport for Unigene cluster: Hs.462983
UniProtKB/Swiss-Prot: MED24_HUMAN, O75448Tissue specificity: Ubiquitous. Abundant in skeletal muscle, heart and placenta
SABiosciences Expression via Pathway-Focused PCR Arrays including MED24: | Epigenetic Chromatin Modification Enzymes in human mouse rat | | Nuclear Receptors & Coregulators in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED24
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED24 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED24 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED24 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED24 |
Orthologs
for MED24 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MED24 gene from 6/20 species (see all 20) About this table
ENSEMBL Gene Tree for MED24 (if available)
TreeFam Gene Tree for MED24 (if available) |
Paralogs
for MED24 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MED24 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MED24 (38175350 - 38217468 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MED24: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MED24 |
|
Disorders
/ Diseases
for MED24 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MED24 for disorders About GeneDecksing
OMIM gene information: 607000
OMIM disorders: --
5  diseases for MED24: About MalaCardstransposition of great arteries thyroiditis congenital heart defect williams syndrome
cholesterol
Export disorders for MED24 gene to outside databases
|
Publications
for MED24 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MED24 gene, integrated from 9 sources (see all 74):
(articles sorted by number of sources associating them with MED24) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S....Conaway R.C. (2004)
- A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. (PubMed id 12218053)1, 2 Wang Q.... Fondell J.D. (2002)
- Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. (PubMed id 10235266)1, 2 Rachez C.... Freedman L.P. (1999)
- Composite co-activator ARC mediates chromatin-directed transcriptional activation. (PubMed id 10235267)1, 2 Naeaer A.M....Tjian R. (1999)
- A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. (PubMed id 10024883)1, 2 Gu W.... Roeder R.G. (1999)
- A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system. (PubMed id 9637681)1, 2 Rachez C.... Freedman L.P. (1998)
- The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. (PubMed id 9653119)1, 2 Yuan C.-X.... Roeder R.G. (1998)
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External Searches for MED24 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing MED24 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing MED24 gene
(According to HUGE)
About This Section
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Specialized Databases showing MED24 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for MED24 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MED24 gene:
Search GeneIP for patents involving MED24
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MED24 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for MED24 | | OriGene shRNA RFP for MED24 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED24 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED24 | | | OriGene Protein Over-expression Lysate for MED24 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MED24 | | OriGene 3'-UTR Clone for MED24 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED24 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED24 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MED24 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MED24 | | OriGene Custom Protein Services for MED24 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MED24 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MED24 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED24 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED24 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED24 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED24 |
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| | | | Search Tocris compounds for MED24 |
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 | | | MED24 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED24 |
|  |  |  | | | | ThermoFisher Antibodies for MED24 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED24 |
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