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MED24 Gene

protein-coding   GIFtS: 57
GCID: GC17M038175

Mediator Complex Subunit 24

(Previous names: thyroid hormone receptor associated protein 4, cofactor...)
(Previous symbols: THRAP4, CRSP4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mediator Complex Subunit 241 2 3     ARC1002 3
CRSP41 2 3     DRIP1002 3
THRAP41 2 3     CRSP Complex Subunit 42 3
TRAP1002 3 5     KIAA01303 5
Cofactor Required For Sp1 Transcriptional Activation, Subunit 4, 100kDa1 2     CRSP1002
Thyroid Hormone Receptor Associated Protein 41 2     Mediator Of RNA Polymerase II Transcription Subunit 242
Activator-Recruited Cofactor 100 KDa Component2 3     Mediator Of RNA Polymerase II Transcription, Subunit 24 Homolog2
Cofactor Required For Sp1 Transcriptional Activation Subunit 42 3     Vitamin D3 Receptor-Interacting Protein Complex Component DRIP1002
Thyroid Hormone Receptor-Associated Protein 42 3     Trap1003
Thyroid Hormone Receptor-Associated Protein Complex 100 KDa Component2 3     hTRAP1003
Vitamin D3 Receptor-Interacting Protein Complex 100 KDa Component2 3     

External Ids:    HGNC: 229631   Entrez Gene: 98622   Ensembl: ENSG000000088387   OMIM: 6070005   UniProtKB: O754483   

Export aliases for MED24 gene to outside databases

Previous GC identifers: GC17M035429 GC17M033969


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MED24 Gene:
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional
coactivator complex thought to be required for the expression of almost all genes. The mediator complex is
recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting
with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MED24 Gene:
MED24 (mediator complex subunit 24) is a protein-coding gene. Diseases associated with MED24 include transposition of the great arteries, and thyroiditis. GO annotations related to this gene include histone acetyltransferase activity and receptor activity.

UniProtKB/Swiss-Prot: MED24_HUMAN, O75448
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED24 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MED24 gene promoter:
         p53   Sp1   AP-1   p300   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MED24 promoter sequence
   Search Chromatin IP Primers for MED24

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MED24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.1   Ensembl cytogenetic band:  17q21.1   HGNC cytogenetic band: 17q21.2

MED24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED24 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M038175:  view genomic region     (about GC identifiers)

Start:
38,175,350 bp from pter      End:
38,217,468 bp from pter
Size:
42,119 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MED24_HUMAN, O75448 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 24  
Size: 989 amino acids; 110305 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with AR
Sequence caution: Sequence=BAA09479.2; Type=Erroneous initiation;
Secondary accessions: A8K4S5 B3KMR9 Q14143 Q9NNY5
Alternative splicing: 2 isoforms:  O75448-1   O75448-2   

Explore the universe of human proteins at neXtProt for MED24: NX_O75448

Explore proteomics data for MED24 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys717, Lys721, Lys856
  • Modification sites at PhosphoSitePlus

  • See MED24 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001072986.1  NP_001254726.1  NP_055630.2  

    ENSEMBL proteins: 
     ENSP00000377684   ENSP00000348610   ENSP00000377686   ENSP00000377685   ENSP00000435760  
     ENSP00000439148   ENSP00000393464   ENSP00000440100   ENSP00000443344   ENSP00000463751  
     ENSP00000463724   ENSP00000463484   ENSP00000392276   ENSP00000463043   ENSP00000438630  
     ENSP00000462646   ENSP00000438767   ENSP00000462539   ENSP00000463528   ENSP00000463480  
     ENSP00000464225  
    Reactome Protein details: O75448

    MED24 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MED24
    OriGene Protein Over-expression Lysate for MED24
    OriGene MassSpec for MED24
    OriGene Custom Protein Services for MED24
    GenScript Custom Purified and Recombinant Proteins Services for MED24
    Novus Biologicals MED24 Proteins
    Novus Biologicals MED24 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MED24

    MED24 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MED24
    OriGene Custom Antibody Services for MED24
    Novus Biologicals MED24 Antibodies
    Search for Antibodies for MED24 at Abcam
    Cloud-Clone Corp. Antibodies for MED24
    ThermoFisher Antibodies for MED24
    LSBio Antibodies in human, mouse, rat for MED24

    MED24 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED24
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED24
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED24
    Cloud-Clone Corp. CLIAs for MED24


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR021429 Mediator_Med24_N

    Graphical View of Domain Structure for InterPro Entry O75448

    ProtoNet protein and cluster: O75448

    UniProtKB/Swiss-Prot: MED24_HUMAN, O75448
    Similarity: Belongs to the Mediator complex subunit 24 family


    MED24 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED24_HUMAN, O75448
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IDA10198638
    GO:0003712transcription cofactor activity IDA12218053
    GO:0003713transcription coactivator activity ----
    GO:0004402histone acetyltransferase activity IEA--
    GO:0004872receptor activity IDA12218053
         
    MED24 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MED24:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Med24):
     cardiovascular system  cellular  embryogenesis  growth/size/body  hematopoietic system 
     mortality/aging  muscle  nervous system 

    MED24 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MED24
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MED24

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MED24
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MED24

    miRNA
    Products:
        
    miRTarBase miRNAs that target MED24:
    hsa-mir-24-3p (MIRT030488), hsa-mir-335-5p (MIRT018060), hsa-mir-98-5p (MIRT027655), hsa-mir-320a (MIRT044508), hsa-mir-766-3p (MIRT039047), hsa-mir-18a-3p (MIRT040976), hsa-mir-197-3p (MIRT048129), hsa-mir-16-5p (MIRT051295), hsa-mir-324-3p (MIRT042865)

    Block miRNA regulation of human, mouse, rat MED24 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MED24:
    hsa-miR-185* hsa-miR-3941
    SwitchGear 3'UTR luciferase reporter plasmidMED24 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MED24
    Predesigned siRNA for gene silencing in human, mouse, rat MED24

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED24

    Clone
    Products:
         
    OriGene clones in human, mouse for MED24 (see all 12)
    OriGene ORF clones in mouse, rat for MED24
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MED24 (NM_014815)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED24
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED24

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MED24
    Browse ESI BIO Cell Lines and PureStem Progenitors for MED24 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED24


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MED24_HUMAN, O75448: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10235267
    GO:0005654nucleoplasm TAS--
    GO:0016592mediator complex NAS9653119

    MED24 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MED24 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    4L1CAM interactions
    Developmental Biology0.63
    5Transcription Ligand Dependent Transcription of Retinoid Target genes
    Transcription Ligand Dependent Transcription of Retinoid Target genes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MED24
        Glucocorticoid Receptor Signaling

    1 GeneGo (Thomson Reuters) Pathway for MED24
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    3 Reactome Pathways for MED24
        Transcriptional regulation of white adipocyte differentiation
    Generic Transcription Pathway
    PPARA activates gene expression


    1 Kegg Pathway  (Kegg details for MED24):
        Thyroid hormone signaling pathway


    MED24 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MED24: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MED24

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MED24 (O754482, 3 ENSP000003486104) via UniProtKB, MINT, STRING, and/or I2D (see all 111)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157962, 3, ENSP000002621604MINT-17220 I2D: score=2 STRING: ENSP00000262160
    MED1Q156482, 3, ENSP000003006514MINT-6744331 I2D: score=1 STRING: ENSP00000300651
    MED14O602442, 3, ENSP000003237204MINT-6744331 I2D: score=1 STRING: ENSP00000323720
    GSK3BP498412, 3MINT-8257449 I2D: score=2 
    RPS6KA6Q9UK322, 3MINT-8269868 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA10198638
    GO:0006366transcription from RNA polymerase II promoter ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--

    MED24 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MED24

    3 Novoseek inferred chemical compound relationships for MED24 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    triiodothyronine 36.9 2 15894578 (1), 10691308 (1)
    retinoic acid 32.8 3 7568167 (1), 9837884 (1), 12554770 (1)
    steroid 26.2 1 10747867 (1)



    MED24 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MED24 gene (3 alternative transcripts): 
    NM_001079518.1  NM_001267797.1  NM_014815.3  

    Unigene Cluster for MED24:

    Mediator complex subunit 24
    Hs.462983  [show with all ESTs]
    Unigene Representative Sequence: NM_014815
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 33):
    ENST00000394126(uc010weq.2 uc010wer.2 uc010wes.2 uc010wet.2 uc002hts.3 uc010wfb.1)
    ENST00000356271(uc010cwn.3) ENST00000394128(uc002htt.3 uc010weu.2 uc010wev.1)
    ENST00000394127(uc002htu.3) ENST00000491466 ENST00000535508 ENST00000579364
    ENST00000422942 ENST00000501516(uc010wfa.1 uc010wfc.1) ENST00000470126
    ENST00000535071(uc010wew.1 uc010wex.1) ENST00000492176 ENST00000580720
    ENST00000580885 ENST00000581058 ENST00000580921 ENST00000584782 ENST00000495586

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MED24 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MED24:
    hsa-miR-185* hsa-miR-3941
    SwitchGear 3'UTR luciferase reporter plasmidMED24 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MED24
    Predesigned siRNA for gene silencing in human, mouse, rat MED24
    Clone
    Products:
         
    OriGene clones in human, mouse for MED24 (see all 12)
    OriGene ORF clones in mouse, rat for MED24
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MED24 (NM_014815)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED24
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED24
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MED24
    OriGene qSTAR qPCR primer pairs in human, mouse for MED24
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED24
      QuantiTect SYBR Green Assays in human, mouse, rat MED24
      QuantiFast Probe-based Assays in human, mouse, rat MED24

    Additional mRNA sequence: 

    AF055995.1 AF277379.1 AK022508.1 AK291040.1 AK293309.1 AK299864.1 AK300992.1 AK303502.1 
    AK303745.1 BC011375.1 D50920.1 EU392533.1 EU392534.1 EU392535.1 EU392536.1 EU392537.1 
    EU392538.1 EU392539.1 EU392540.1 EU392541.1 EU392542.1 EU392543.1 EU392544.1 EU392545.1 
    EU392546.1 EU392547.1 EU392548.1 EU392549.1 EU392550.1 EU392551.1 EU392552.1 EU392553.1 
    EU392554.1 NR_052017.1 

    Selected DOTS entries (see all 40):

    DT.92446610  DT.120980045  DT.100030566  DT.100729255  DT.120980122  DT.120980121  DT.100794788  DT.95212192 
    DT.453007  DT.70101420  DT.102830372  DT.91953039  DT.95329126  DT.120980136  DT.92446601  DT.102830374 
    DT.120980104  DT.100718201  DT.100671636  DT.95329133  DT.120980117  DT.120980006  DT.95131104  DT.100794786 

    Selected AceView cDNA sequences (see all 360):

    AW024770 AW005255 D50920 BU943465 BF969030 BM461536 AU125125 CB105741 
    BU730123 BQ888687 AI346721 BU193768 BU542010 BX378723 CA454359 BM558094 
    BU185232 BM834189 AU121607 CD652191 BU149988 CF147497 BM556394 BQ071494 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MED24 (see all 44)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e ·
    SP1:                          -     -     -     -     -                 -           -     -     -           -     -                                             
    SP2:                          -     -     -     -                       -           -     -     -     -     -     -                                             
    SP3:                                                                    -           -     -     -           -     -                                             
    SP4:                          -     -     -     -                       -           -     -     -           -     -                                             
    SP5:                          -     -     -     -                       -           -     -     -           -     -                                             

    ExUns: 9f · 9g · 9h · 9i · 9j · 9k ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e · 12f ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
    SP1:                                      -     -     -     -                                                           -                                       
    SP2:                                      -     -     -     -                                                           -                                       
    SP3:                                      -     -     -     -                                                           -                                       
    SP4:                                            -     -     -                                                                                                   
    SP5:                                      -     -     -     -                                                                                                   

    ExUns: 19b ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b · 24c ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31a · 31b ^ 32a · 32b ^
    SP1:        -           -                             -                                                                       -     -     -           -         
    SP2:        -           -                             -                                                                       -     -     -           -         
    SP3:        -           -                             -                                                                       -     -     -           -         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 33a · 33b · 33c · 33d ·
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for MED24

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MED24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAAATAAA
    MED24 Expression
    About this image

    MED24 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MED24 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.462983

    UniProtKB/Swiss-Prot: MED24_HUMAN, O75448
    Tissue specificity: Ubiquitous. Abundant in skeletal muscle, heart and placenta

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MED24: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MED24 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med241 , 5 mediator complex subunit 241, 5 88.86(n)1
    94.43(a)1
      11 (62.46 cM)5
    239891  NM_011869.21  NP_035999.21 
     987045915 
    chicken
    (Gallus gallus)
    Aves MED241 mediator complex subunit 24 81.46(n)
    86.9(a)
      426134  NM_001031363.1  NP_001026534.1 
    lizard
    (Anolis carolinensis)
    Reptilia MED246
    mediator complex subunit 24
    84(a)
    1 ↔ 1
    6(69002467-69075908)
    African clawed frog
    (Xenopus laevis)
    Amphibia thrap4-prov2 thyroid hormone receptor-associated protein (100 kDa) 76.38(n)    BC043802.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM316662.12   -- 75.4(n)    BM316662.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED241 Mediator complex subunit 24 45.04(n)
    29.65(a)
      38914  NM_139928.5  NP_648185.1 


    ENSEMBL Gene Tree for MED24 (if available)
    TreeFam Gene Tree for MED24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MED24 (see all 824)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22273361,2
    C,F,A,H--38174855(+) GAAGTT/GCCCAC 4 -- ds500112Minor allele frequency- G:0.40NS NA WA CSA EA 464
    rs773222971,2
    F--38174913(+) GGCAAG/TGAAGG 4 -- ds50011Minor allele frequency- T:0.01EA 120
    rs1872588021,2
    --38174933(+) AGGTCC/TGGCCC 4 -- ds50010--------
    rs1921428441,2
    --38175065(+) CCCAGC/TACTGT 4 -- ds50010--------
    rs1845396101,2
    --38175245(+) CTCCTC/GCTCCT 4 -- ds50010--------
    rs1905798311,2
    --38175268(+) GAGCCA/GTTCCC 4 -- ds50010--------
    rs10459291,2
    C,F,A,H--38175426(-) TGTTTG/ATGTGT 4 -- ut31 nc-transcript-variantese318Minor allele frequency- A:0.38MN NS EA NA WA CSA 2154
    rs717843531,2
    C--38175429(+) ACAAA-/AC/ACAC
    /ACACACAC
    CACAC
    12 -- ut31 nc-transcript-variant1CSA 2
    rs11287181,2
    C,F--38175456(-) TGTATA/C/G/
            
    TGTGT
    12 -- ut31 nc-transcript-variant3WA NA CSA 6
    rs3711968491,2
    C--38175456(+) cacac-/ACACAC
    AT
    /AT/CA
    ataca
    12 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for MED24 (38175350 - 38217468 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MED24:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908220CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MED24
    DNA2.0 Custom Variant and Variant Library Synthesis for MED24

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607000    OMIM disorders: --

    9 diseases for MED24:    
    About MalaCards
    transposition of the great arteries    thyroiditis    congenital heart defect    hypoxia
    melanoma    multiple myeloma    myeloma    malaria
    breast cancer


    MED24 for disorders           About GeneDecksing


    Export disorders for MED24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MED24 gene, integrated from 10 sources (see all 82):
    (articles sorted by number of sources associating them with MED24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (Mol. Cell 2005)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S.... Conaway R.C. (Mol. Cell 2004)
    5. A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. (PubMed id 12218053)1, 2 Wang Q.... Fondell J.D. (J. Biol. Chem. 2002)
    6. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. (PubMed id 10235266)1, 2 Rachez C.... Freedman L.P. (Nature 1999)
    7. Composite co-activator ARC mediates chromatin-directed transcriptional activation. (PubMed id 10235267)1, 2 Naeaer A.M....Tjian R. (Nature 1999)
    8. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. (PubMed id 10024883)1, 2 Gu W.... Roeder R.G. (Mol. Cell 1999)
    9. A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system. (PubMed id 9637681)1, 2 Rachez C.... Freedman L.P. (Genes Dev. 1998)
    10. The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. (PubMed id 9653119)1, 2 Yuan C.-X.... Roeder R.G. (Proc. Natl. Acad. Sci. U.S.A. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9862 HGNC: 22963 AceView: THRAP4 Ensembl:ENSG00000008838 euGenes: HUgn9862
    ECgene: MED24 Kegg: 9862 H-InvDB: MED24

    (According to HUGE)
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    HUGE: KIAA0130

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MED24 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MED24 gene:
    Search GeneIP for patents involving MED24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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