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Aliases for MED24 Gene

Aliases for MED24 Gene

  • Mediator Complex Subunit 24 2 3 4 5
  • Cofactor Required For Sp1 Transcriptional Activation, Subunit 4, 100kDa 2 3
  • Thyroid Hormone Receptor-Associated Protein Complex 100 KDa Component 3 4
  • Vitamin D3 Receptor-Interacting Protein Complex 100 KDa Component 3 4
  • Cofactor Required For Sp1 Transcriptional Activation Subunit 4 3 4
  • Activator-Recruited Cofactor 100 KDa Component 3 4
  • Thyroid Hormone Receptor-Associated Protein 4 3 4
  • CRSP Complex Subunit 4 3 4
  • DRIP100 3 4
  • TRAP100 3 4
  • THRAP4 3 4
  • ARC100 3 4
  • CRSP4 3 4
  • Vitamin D3 Receptor-Interacting Protein Complex Component DRIP100 3
  • Mediator Of RNA Polymerase II Transcription, Subunit 24 Homolog 3
  • Mediator Of RNA Polymerase II Transcription Subunit 24 3
  • Thyroid Hormone Receptor Associated Protein 4 2
  • KIAA0130 4
  • HTRAP100 4
  • CRSP100 3
  • MED5 3

External Ids for MED24 Gene

Previous HGNC Symbols for MED24 Gene

  • THRAP4
  • CRSP4

Previous GeneCards Identifiers for MED24 Gene

  • GC17M035429
  • GC17M038175
  • GC17M033969

Summaries for MED24 Gene

Entrez Gene Summary for MED24 Gene

  • This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MED24 Gene

MED24 (Mediator Complex Subunit 24) is a Protein Coding gene. Diseases associated with MED24 include Transposition Of The Great Arteries. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Thyroid hormone signaling pathway. GO annotations related to this gene include receptor activity and transcription cofactor activity.

UniProtKB/Swiss-Prot for MED24 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED24 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED24 Gene

Genomics for MED24 Gene

Regulatory Elements for MED24 Gene

Enhancers for MED24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MED24 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MED24 gene promoter:

Genomic Location for MED24 Gene

Chromosome:
17
Start:
40,019,097 bp from pter
End:
40,061,215 bp from pter
Size:
42,119 bases
Orientation:
Minus strand

Genomic View for MED24 Gene

Genes around MED24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED24 Gene

Proteins for MED24 Gene

  • Protein details for MED24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75448-MED24_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 24
    Protein Accession:
    O75448
    Secondary Accessions:
    • A8K4S5
    • B3KMR9
    • Q14143
    • Q9NNY5

    Protein attributes for MED24 Gene

    Size:
    989 amino acids
    Molecular mass:
    110305 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with AR.
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with AR.
    SequenceCaution:
    • Sequence=BAA09479.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MED24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED24 Gene

Post-translational modifications for MED24 Gene

  • Ubiquitination at Lys 717, Lys 721, and Lys 856
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MED24 Gene

Domains & Families for MED24 Gene

Gene Families for MED24 Gene

Protein Domains for MED24 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O75448

UniProtKB/Swiss-Prot:

MED24_HUMAN :
  • Belongs to the Mediator complex subunit 24 family.
Family:
  • Belongs to the Mediator complex subunit 24 family.
genes like me logo Genes that share domains with MED24: view

Function for MED24 Gene

Molecular function for MED24 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IDA 10198638
GO:0003712 transcription cofactor activity IDA 12218053
GO:0003713 transcription coactivator activity IEA --
GO:0004402 histone acetyltransferase activity IEA --
GO:0004872 receptor activity IDA 12218053
genes like me logo Genes that share ontologies with MED24: view
genes like me logo Genes that share phenotypes with MED24: view

Animal Models for MED24 Gene

MGI Knock Outs for MED24:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MED24 Gene

Localization for MED24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED24 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED24 Gene COMPARTMENTS Subcellular localization image for MED24 gene
Compartment Confidence
nucleus 5
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for MED24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IEA --
GO:0005634 nucleus IDA 10235267
GO:0005654 nucleoplasm TAS --
GO:0016592 mediator complex NAS 9653119
genes like me logo Genes that share ontologies with MED24: view

Pathways & Interactions for MED24 Gene

genes like me logo Genes that share pathways with MED24: view

Pathways by source for MED24 Gene

Gene Ontology (GO) - Biological Process for MED24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0016567 protein ubiquitination IEA --
GO:0016573 histone acetylation IEA --
genes like me logo Genes that share ontologies with MED24: view

No data available for SIGNOR curated interactions for MED24 Gene

Drugs & Compounds for MED24 Gene

(1) Drugs for MED24 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MED24 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MED24: view

Transcripts for MED24 Gene

Unigene Clusters for MED24 Gene

Mediator complex subunit 24:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED24 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7:
SP8: - - - - - -
SP9: - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - - - - - - -
SP11: - -
SP12: - - - - - - - - - -
SP13: - - - - - - - - -
SP14: - - - - - - - -
SP15: - - - - - - - - -
SP16: - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - -
SP18: - - - - - - - - - - - - -
SP19: - - - - - - - - - - - -
SP20: - - - - - - - - - -
SP21: - - - - - - - - -
SP22: - - - - -
SP23: - - - - - - - - - - - - -
SP24: - - - - - - - - -
SP25: - - - - - - - - - -
SP26:
SP27: - - - - - - - - - - - -
SP28: - - - - - - - - - - - - -
SP29: - - - - - - - - -
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SP35: - - - - - - - - - -
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SP37: - - - - - - - - -
SP38:
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SP40:
SP41: - - - - -
SP42:
SP43:
SP44:

ExUns: 9f · 9g · 9h · 9i · 9j · 9k ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e · 12f ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7:
SP8:
SP9: - - - - -
SP10: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP11: - - -
SP12:
SP13:
SP14:
SP15:
SP16: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP17:
SP18: - - - -
SP19: - - - -
SP20:
SP21:
SP22: - - - -
SP23:
SP24:
SP25:
SP26:
SP27:
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SP33:
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SP35:
SP36:
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SP38:
SP39: -
SP40:
SP41:
SP42:
SP43:
SP44:

ExUns: 19b ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b · 24c ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31a · 31b ^ 32a · 32b ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4:
SP5:
SP6:
SP7: - - - -
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - - - - - - - - - - - - - - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26: - - -
SP27:
SP28:
SP29:
SP30: - - -
SP31: - - -
SP32: - - -
SP33: -
SP34: -
SP35:
SP36:
SP37:
SP38:
SP39:
SP40:
SP41:
SP42: - -
SP43:
SP44: -

ExUns: 33a · 33b · 33c · 33d ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
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SP19:
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SP24:
SP25:
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SP34:
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SP38:
SP39:
SP40:
SP41:
SP42:
SP43:
SP44:

Relevant External Links for MED24 Gene

GeneLoc Exon Structure for
MED24
ECgene alternative splicing isoforms for
MED24

Expression for MED24 Gene

mRNA expression in normal human tissues for MED24 Gene

Protein differential expression in normal tissues from HIPED for MED24 Gene

This gene is overexpressed in Breast (19.8) and Blymphocyte (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MED24 Gene



Protein tissue co-expression partners for MED24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MED24 Gene:

MED24

SOURCE GeneReport for Unigene cluster for MED24 Gene:

Hs.462983

mRNA Expression by UniProt/SwissProt for MED24 Gene:

O75448-MED24_HUMAN
Tissue specificity: Ubiquitous. Abundant in skeletal muscle, heart and placenta.
genes like me logo Genes that share expression patterns with MED24: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MED24 Gene

Orthologs for MED24 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED24 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MED24 34
  • 90.39 (n)
  • 96.36 (a)
MED24 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED24 34
  • 91.07 (n)
  • 96.16 (a)
MED24 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med24 34
  • 88.86 (n)
  • 94.43 (a)
Med24 16
Med24 35
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MED24 34
  • 99.7 (n)
  • 100 (a)
MED24 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med24 34
  • 88.96 (n)
  • 94.73 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 92 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 78 (a)
OneToMany
-- 35
  • 79 (a)
OneToMany
chicken
(Gallus gallus)
Aves MED24 34
  • 81.46 (n)
  • 86.9 (a)
MED24 35
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MED24 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491557 34
  • 72.45 (n)
  • 77.18 (a)
African clawed frog
(Xenopus laevis)
Amphibia thrap4-prov 34
zebrafish
(Danio rerio)
Actinopterygii med24 34
  • 70.39 (n)
  • 76.27 (a)
med24 35
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta MED24_ANOGA 34
  • 48.6 (n)
  • 31.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta MED24 34
  • 45.04 (n)
  • 29.65 (a)
MED24 35
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
OneToOne
Species where no ortholog for MED24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MED24 Gene

ENSEMBL:
Gene Tree for MED24 (if available)
TreeFam:
Gene Tree for MED24 (if available)

Paralogs for MED24 Gene

No data available for Paralogs for MED24 Gene

Variants for MED24 Gene

Sequence variations from dbSNP and Humsavar for MED24 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs34585432 - 40,033,406(+) ATTGG(C/T)CAGGA nc-transcript-variant, reference, missense
rs12309 -- 40,019,209(-) AAAGT(A/G)TGTAT nc-transcript-variant, utr-variant-3-prime
rs709591 -- 40,019,308(-) AGGAG(A/T)GTGAG nc-transcript-variant, utr-variant-3-prime
rs709592 -- 40,019,300(-) GAGCA(A/G)CCTGG nc-transcript-variant, utr-variant-3-prime
rs1045905 -- 40,019,241(-) GTAGT(C/T)TTACC nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MED24 Gene

Variant ID Type Subtype PubMed ID
esv3573064 CNV gain 25503493
nsv1146669 OTHER inversion 26484159

Variation tolerance for MED24 Gene

Residual Variation Intolerance Score: 7.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MED24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED24 Gene

Disorders for MED24 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MED24 Gene - From: GeneCards

Disorder Aliases PubMed IDs
transposition of the great arteries
  • dtga
- elite association - COSMIC cancer census association via MalaCards
Search MED24 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MED24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED24
genes like me logo Genes that share disorders with MED24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MED24 Gene

Publications for MED24 Gene

  1. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X. … Roeder R.G. (Mol. Cell 2005) 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. (PMID: 11867769) Kang Y.K. … Roeder R.G. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 22 65

Products for MED24 Gene

Sources for MED24 Gene

Content